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Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort.
- Source :
-
Pediatric obesity [Pediatr Obes] 2023 Feb; Vol. 18 (2), pp. e12982. Date of Electronic Publication: 2022 Oct 11. - Publication Year :
- 2023
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Abstract
- Background: Childhood obesity has been associated with prenatal exposure to maternal hyperglycaemia, but we lack understanding about maternal insulin physiologic components that contribute to this association.<br />Objectives: Evaluate the association between maternal insulin sensitivity during pregnancy and adiposity measures in childhood.<br />Methods: In 422 mother-child pairs, we tested associations between maternal insulin sensitivity measures at ~26 weeks of pregnancy and child adiposity measures, including dual-energy X-ray absorptiometry body composition and anthropometry (body mass index and waist circumference) at ~5 years. We used linear regression analyses to adjust for maternal age, ethnicity, gravidity, first-trimester body mass index, and child sex and age at mid-childhood.<br />Results: In early pregnancy, maternal mean age was 28.6 ± 4.3 years and median body mass index was 24.1 kg/m <superscript>2</superscript> . Lower maternal insulin sensitivity indices were correlated with greater child adiposity based on anthropometry measures and on dual-energy X-ray absorptiometry total and trunk % fat in univariate associations (r = -0.122 to -0.159). Lower maternal insulin sensitivity was specifically associated with higher dual-energy X-ray absorptiometry trunk % fat (n = 359 for Matsuda; β = -0.034 ± 0.013; p = 0.01) after adjustment for covariates, including maternal body mass index.<br />Conclusions: Maternal insulin sensitivity during pregnancy may contribute to increased risk for higher offspring central adiposity in middle childhood.<br /> (© 2022 World Obesity Federation.)
Details
- Language :
- English
- ISSN :
- 2047-6310
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric obesity
- Publication Type :
- Academic Journal
- Accession number :
- 36218084
- Full Text :
- https://doi.org/10.1111/ijpo.12982