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Aim: This study aimed to describe the status and analyze the improvements made by universities in Kazakhstan to nursing research infrastructure in the following services: library, internationalization, finance, information and communication technology (ICT), and research, development, and innovation (RDI)., Background: In higher education institutions (HEIs), a strong research infrastructure is a necessity for academic education and research. In Central Asian countries, nursing is regarded as an assistive field to medicine, affecting nursing research infrastructures., Methods: In this descriptive study, following benchmarking and a recommendations report, an interview of nursing faculty members was used to obtain data regarding nursing research infrastructure in ten universities in Kazakhstan. The SQUIRE-EDU was used to ensure the quality of reporting., Results: The Kazakhstani universities providing nursing education are still in the process of developing their nursing research infrastructure. They have not acquired access to nursing databases, and only one textbook concerning nursing research can be found from their libraries. None of the universities have joined international nursing networks. The participation of the university staff and students in conferences with nursing themes has increased. The universities are investing in staff capacity building, but not yet in nursing research projects., Discussion and Conclusion: Kazakhstani universities have the autonomy to develop nursing research and its infrastructure. Active measures by the university management, such as financing access to nursing databases, international cooperation, and international projects, are necessary., Implications for Nursing and Health Policy: Research infrastructures' quality strongly impacts the development of nursing science and practice in any country. It is crucial to increase the volume of research that demonstrates the effectiveness of clinical nursing and its contribution to health outcomes. To enable the faster development of nursing science in Central Asian countries, this development should be supported through international collaboration., (© 2022 The Authors. International Nursing Review published by John Wiley & Sons Ltd on behalf of International Council of Nurses.)

The relevance of the present research is related to the great importance of Karakul sheep breeding in Kazakhstan and the insufficient investigation of morphological features of the skin and hair cover of Karakul lambs in modern literature. The purpose of the research was to explore the specific features of hair pigmentation and histological structure of the skin of Karakul lambs of different colour groups: black, sur, grey, and brown. The work involved the standard methods of assessing the pigment content in the hair of lambs and methods of histological studies. The study utilised statistical methods including the Kolmogorov-Smirnov criterion, one-factor analysis of variance, Fisher's F-criterion, and the Bonferroni method, with data processed through the "PASW Statistics 17" and "Statistica 6.0" software packages. The results of the research demonstrate that the pigment content in the hair of new-born Karakul lambs depends on their colouring. Differences in pigment precipitation between different colour groups of lambs were established: pigment grains in black hairs and suras were larger, in comparison with brown and grey hairs, in which pigment was represented by the smallest grains. At the age of 19 days, no significant changes in the colouring of the lambs examined were found (p > 0.05), whereas on reaching 4 months of age, depigmentation (p < 0.05) was noted in all colour groups, which was slower in black lambs., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)

Peste des petits ruminants (PPR) is a viral transboundary disease seen in small ruminants, that causes significant damage to agriculture. This disease has not been previously registered in the Republic of Kazakhstan (RK). This paper presents an assessment of the susceptibility of the RK's territory to the spread of the disease in the event of its importation from infected countries. The negative binomial regression model that was trained on the PPR outbreaks in China, was used to rank municipal districts in the RK in terms of PPR spread risk. The outbreak count per administrative district was used as a risk indicator, while a number of socio-economic, landscape, and climatic factors were considered as explanatory variables. Summary road length, altitude, the density of small ruminants, the maximum green vegetation fraction, cattle density, and the Engel coefficient were the most significant factors. The model demonstrated a good performance in training data (R 2  = 0.69), and was transferred to the RK, suggesting a significantly lower susceptibility of this country to the spread of PPR. Hot spot analysis identified three clusters of districts at the highest risk, located in the western, eastern, and southern parts of Kazakhstan. As part of the study, a countrywide survey was conducted to collect data on the distribution of livestock populations, which resulted in the compilation of a complete geo-database of small ruminant holdings in the RK. The research results may be used to formulate a national strategy for preventing the importation and spread of PPR in Kazakhstan through targeted monitoring in high-risk areas., (© 2021 Wiley-VCH GmbH.)

There is an assumption that with the disintegration of the Soviet Union, the Second World ceased to exist. Yet the demise of the Communist bloc as a geopolitical reality did not mean that it stopped exerting a defining influence over how people think and behave. This article examines how the postsocialist state in Kazakhstan deals with potential crises such as earthquakes and the extent to which the Soviet legacy still shapes intellectual debates, state structures, and civil society organisations in in that country. Drawing on fieldwork and interviews, this paper re-examines the Second World in its historical context and re-establishes it as a conceptual framework for considering disaster risk reduction in the former Soviet bloc. It argues that it is essential to pay attention to this legacy in Kazakhstan both in policy and practice if earthquake risk reduction is to be made more effective., (© 2019 The Authors Disasters © 2019 Overseas Development Institute.)

The author examines the flow of the non-Kazakh population from the territory of Kazakhstan since the country became independent in December 1991. "This study [analyzes] the ongoing migration process from...a Kazakh point-of-view--meaning, not from the position of a Kazakh ¿nationalist' but from a pragmatic stance, taking into consideration the specific elements of the situation in the country. In particular, it is suggested that the ¿nationalist' interpretation (which is not actively promoted in the country's internal politics, by the way) is less than ideal as a scientific explanation of this migration, and various other contributing factors will be presented.", (excerpt)

The Aim Was: This study explored the perspectives of nursing, medical and public health students on environmental sustainability in healthcare., Background: The healthcare sector has increasingly recognized the importance of adopting environmental sustainability over the past few years. This growing awareness emphasizes the need to thoroughly assess the connection between health care and environmental responsibility., Design: Qualitative descriptive-exploratory design., Methods: This study explored the views on environmental sustainability in health care of 29 nursing, medical and public health students at three universities in Kazakhstan through focus group discussions. Thematic analysis was used in the data analysis. Data collection was carried out from June to August 2023., Results: Using semantic thematic analysis, 209 initial codes were extracted, and then similar codes and meanings were grouped, leading to 21 categories until the development of the five significant themes. The five main themes are 'the impact of the environment on health', 'environmental sustainability practices in healthcare care', 'the importance of interdisciplinary collaboration in environmental sustainability in healthcare', 'intrinsic motivation to engage in environmental sustainability practices in healthcare' and 'challenges and barriers to practicing environmental sustainability in healthcare'., Conclusions: The study findings suggest the critical aspect of addressing environmental sustainability through interprofessional collaboration and working on intrinsic motivation among health professionals. Furthermore, our study contributes in several ways to our understanding of environmental sustainability in healthcare. Provides a basis for clinicians, educators and policy makers to consider adding sustainability to their agenda to prepare future health professionals., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: This paper aimed to describe the National Centre for Neurosurgery, the only specialized hospital in the treatment of neurological diseases in Kazakhstan and the leading neurosurgical hospital in Central Asia., Methods: Historical data were collected from the archive materials of the National Centre for Neurosurgery., Results: The paper outlines the achievements of the Centre in providing neurosurgical care to the population over the past 15 years, commencing with its establishment in 2008. During this period, there has been a 2.3-fold increase in the number of neurosurgeons at the Centre, accompanied by a significant seven-fold rise in the number of surgeries conducted. Additionally, the Centre has hosted international conferences and educational programs in collaboration with the Asian Congress of Neurological Surgeons and the European Association of Neurosurgical Societies. Throughout the last 15 years, more than 70 treatment techniques were introduced, and subsequent technology transfer initiatives extended these methods to regions within the country., Conclusions: The National Centre for Neurosurgery has achieved remarkable progress in delivering patient-centered neurosurgical care, rehabilitation programs, and innovative treatments, supported by state funding, benefitting patients across Central Asia., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Hexavalent chromium (Cr(VI)) is a known carcinogen derived from both anthropogenic and natural sources. This work reports the size-segregated concentrations of total Cr(VI) in particulate matter (PM) in Astana, the capital of Kazakhstan, and provides new insights into the gas-solid reactions of atmospheric Cr. A study of total Cr(VI) in the particulate matter, via a microwave-assisted digestion technique, was conducted using a 5-stage Sioutas Cascade impactor that captures airborne particles in size ranges: >2.5 μm, 1.0-2.5 μm, 0.50-1.0 μm, 0.25-0.50 μm, and <0.25 μm. The total Cr(VI) concentration in the size fraction <0.25 μm was the highest with a maximum value of 9.7 ng/m 3 . This high concentration may pose a greater risk because smaller airborne particles can penetrate deeper into the lower respiratory tract of the lungs. Total suspended particles Cr(VI) exceeded the 8.0 ng/m 3 Reference Concentration (RfC) by 22 times. The overall total Cr(VI) concentration in summer was significantly higher than in fall (p < 0.05), which could be due to factors, including higher temperatures, ozone, and NO 2 concentrations in summer and a higher VOC concentration in fall. The results indicate that the interaction between Cr(III) and Cr(VI) through gas-solid reaction can control the speciation of atmospheric Cr., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Following a 2-week trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was immediately treated with intravenous artesunate and transferred to an intensive care unit. The initial parasite density was as high as 30% infected erythrocytes with 845,880 parasites/µL. Since Kazakhstan was declared malaria-free in 2012, molecular testing for Plasmodium has been initiated to identify a possible origin. Genotyping of the msp-1 gene and microsatellite markers showed that the parasites are of African origin, with two different alleles indicating a polyclonal infection. After a hospitalization of 10 days, the patient was discharged in good health. Overall, our results emphasize that malaria must be on the list of differential diagnoses for patients with fever of unknown origin, even if they come from countries where malaria does not commonly occur., Competing Interests: Declarations of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)

The Aral Sea Basin in Central Asia faces significant challenges in improving water utilization and treatment because of frequent transboundary river water disputes and shortages of water resources. However, the traditional water resource utilization efficiency (WRUE) assessment models generally have the defect of over-validating evaluation results. To solve this problem, this study used the Coefficient of Variation method to constrain the self-contained weights in the traditional Data Envelopment Analysis (DEA) to construct an improved CV-DEA model, and assessed the WRUE of the Aral Sea Basin countries during 2000-2018 and compared the WRUE with that of the countries in the Mekong River Basin and Northeast Asia, then explored the factors influencing water utilization. The conclusions were drawn: since 1960, the runoff from the upper Amu Darya and Syr Darya rivers increased significantly, while the runoff from the lower Amu Darya River into the Aral Sea declined. Meanwhile, the water area of the Aral Sea shrank from 2.56 × 10 4  km 2 to 0.70 × 10 4  km 2 in 2000-2018, with the Northern Aral Sea remaining stable while the southern part shrinking sharply. The WRUE of the Aral Sea Basin (0.599, on average) was higher than that of the Mekong River Basin (0.547) and lower than that of Northeast Asia (0.885). Kazakhstan and Uzbekistan had the highest WRUE of 0.819 and 0.685 respectively, and the WRUE in both two countries improved from 2000 to 2018. Tajikistan (0.495) and Turkmenistan (0.402) experienced decreases in WRUEs. The high input redundancy of agricultural water consumption was the main driving force affecting WRUE in the basin., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: The growing population of older adults, often affected by chronic illnesses, disabilities, or frailty has led to a substantial increase in the need for informal caregivers., Objective: This paper is a protocol for a study that aims to investigate the effects of caregiving on informal caregivers of older adults in Kazakhstan with special emphasis on the cultural context., Methods: The protocol outlines a mixed-methods study that will be conducted in four cities in Kazakhstan. A total of 400 informal caregivers of older adults with two or more limitations in Activities of Daily Living (ADL) will be recruited to participate in a survey, aiming to evaluate care-related burdens and quality of life and health-related quality of life. The Institute for Medical Technology Assessment (iMTA) Valuation of Informal Care Questionnaire (iVICQ) was selected to be the main research instrument. Additionally, a subset of participants who express their willingness to participate will be selected from the pool of survey respondents to engage in semi-structured interviews, allowing for a deeper understanding of their experiences and providing insights into their social and medical support needs., Conclusion: This study will be the first investigation of the impact of caregiving on informal caregivers of older adults in Central Asia. The results will contribute to the literature by providing insights into older adults care within the specific national and cultural context of Kazakhstan with potential generalization to other Central Asian republics of the former USSR., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhylkybekova, Grjibovski, Glushkova and Koshmaganbetova.)

Background: Retraction is a correction process for the scientific literature that acts as a barrier to the dissemination of articles that have serious faults or misleading data. The purpose of this study was to investigate the characteristics of retracted papers from Kazakhstan., Methods: Utilizing data from Retraction Watch, this cross-sectional descriptive analysis documented all retracted papers from Kazakhstan without regard to publication dates. The following data were recorded: publication title, DOI number, number of authors, publication date, retraction date, source, publication type, subject category of publication, collaborating country, and retraction reason. Source index status, Scopus citation value, and Altmetric Attention Score were obtained., Results: Following the search, a total of 92 retracted papers were discovered. One duplicate article was excluded, leaving 91 publications for analysis. Most articles were retracted in 2022 (n = 22) and 2018 (n = 19). Among the identified publications, 49 (53.9%) were research articles, 39 (42.9%) were conference papers, 2 (2.2%) were review articles, and 1 (1.1%) was a book chapter. Russia (n = 24) and China (n = 5) were the most collaborative countries in the retracted publications. Fake-biased peer review (n = 38), plagiarism (n = 25), and duplication (n = 14) were the leading causes of retraction., Conclusion: The vast majority of the publications were research articles and conference papers. Russia was the leading collaborative country. The most prominent retraction reasons were fake-biased peer review, plagiarism, and duplication. Efforts to raise researchers' understanding of the grounds for retraction and ethical research techniques are required in Kazakhstan., Competing Interests: The authors have no potential conflicts of interest to disclose., (© 2023 The Korean Academy of Medical Sciences.)

The coronavirus pandemic, besides generating health distress, influences the socio-economic conditions of humankind. Every adolescent's lifestyle is affected by the virus. Healthy adolescents are not only key contributors to the forthcoming workforce but also a source of a country's human capital. The purpose of the article is to examine the efficacy of various Asian countries in regulating the spread of the coronavirus among adolescents. In addition to that, the paper also attempts to pinpoint the prime causes of the inefficiency of a country in regulating the same. The paper also examines the behavioural changes among adolescents across Asian countries in pre-and-post pandemic times. In this context, the study identifies the impact of adolescents' tobacco consumption, female political leadership, and accreditation on a country's efficacy to regulate adolescents' coronavirus infection. The study's empirical analysis covers twenty-one Asian countries. By using the Panel Stochastic Production Frontier, the study concludes that Kazakhstan is the most efficient country and Afghanistan is the least efficient country on the list. The inefficiency effects estimates conclude that adolescents' tobacco consumption decreases and good governance practices increase the efficiency of a country in regulating the spread of adolescent coronavirus infection. Additionally, the paper finds no significant behavioural changes among adolescents in pre-and-post pandemic times across Asian countries. The paper concludes with appropriate policy recommendations supported by empirical evidence. The paper also identifies its shortcomings and suggests potential future lines of inquiry., (© 2023. The Author(s).)

The presence of significant areas used for pastures in Kazakhstan makes it relevant to study the epizootic situation in terms of the incidence of animals during their grazing. The most frequent and dangerous diseases during this period are clostridiosis and listeriosis, which cause significant damage to livestock. Monitoring studies of the dynamics of morbidity among animals for infectious diseases during the grazing period were carried out on the basis of veterinary reporting. Bacteriological studies were carried out in a state laboratory using generally accepted microbiological methods. Analytical and statistical methods were used during the work. Monitoring studies indicate a significant spread of clostridiosis in the territory of Kazakhstan. The highest incidence rate was characterised by emphysematous carbuncle infection, which was recorded throughout the country, with an average frequency of about 40 cases per year. The incidence of braxy and anaerobic enterotoxemia occurred much less frequently and mainly in the southern regions of the country. Listeriosis was also observed only in some regions, but at the same time, a stationary focus of the disease was recorded in the Utylaut region, where cases of the disease are recorded annually. Conducted research made it possible to form the dynamics of the incidence of animals in the pasture period for these diseases, to determine the regions of the country with different intensity of the epizootic situation, as well as to carry out bacteriological isolation of a pure culture of the pathogen from samples taken in the foci of the disease. The studies made it possible to collect information on the features and mechanisms of the occurrence of diseases in the conditions of different regions of Kazakhstan and to develop a multi-vector strategy for preventive measures to eliminate animal diseases during the grazing period., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Emerging countries are at the frontier of climate change actions, and carbon emissions accounting provides a quantifiable measure of the environmental impact of economic activities, which allows for comparisons of emissions across different entities. However, currently there is no study covering detailed emissions inventories for emerging countries in Central Asian. This paper compiles detailed and accurate carbon emissions inventories in several Central Asian countries (i.e., Kazakhstan, Kyrgyzstan, Pakistan, Palestine, Tajikistan, and Uzbekistan) during the period 2010-2020. Using the IPCC administrative territorial approach, we for the first time compile their emissions inventories in 47 economic sectors and five energy categories. Moreover, we also investigate decoupling status based on Tapio decoupling model and examine emissions driving factors based on the index decomposition analysis method. The primary results illustrate that carbon emissions in Central Asian countries are increasing with huge differences. Decoupling results highlight that most of the sample countries still need more effort to decouple the economy and emissions except that Pakistan achieves an ideal strong decoupling state. The results of the decomposition indicate that the economy and population both raise emissions, while energy intensity and carbon intensity are negative drivers in some countries. We propose practical policy implications for decarbonization and energy transition roadmap in Central Asian countries., (© 2023. The Author(s).)

The problems of schizophrenia therapy occupy a leading place in both foreign and domestic clinical psychiatry. The paper presents the results of a study to identify reliable biomarkers for predicting antipsychotic therapy of patients with paranoid schizophrenia of the Kazakh ethnic group in the Republic of Kazakhstan, conducted within the framework of the project: "National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan" IRN ОР12165486. The effectiveness and tolerability of antipsychotic drugs used in the treatment of paranoid schizophrenia in the Republic of Kazakhstan according to clinical treatment protocols are analyzed. Gender and age-specific dynamics in the clinic of paranoid schizophrenia in antipsychotic therapy in persons of Kazakh ethnicity are described. Certain genetic features of representatives of the Kazakh ethnic group have been identified, which can influence the effectiveness and tolerability of antipsychotic drugs, which determines the basis of an innovative approach to personalized therapy of paranoid schizophrenia in patients of the Kazakh ethnic group in the Republic of Kazakhstan.

The relevance of the problem of the stated topic lies in the fact that the causative agent of the plague infection demonstrates high survival while maintaining high virulence in the territories, which are enzootic in terms of the plague. The study aimed to investigate the geographic distribution and genetic diversity of the plague pathogen in endemic regions through molecular genetic research. The work included the results of laboratory studies of 3058 samples, including soil - 1154, burrow substrates - 549, the contents of the feeding chamber - 349, bone remains - 18, biological objects - 988 samples of sera and suspensions from carriers and vectors of plague infection collected from 14 autonomous plague foci of Kazakhstan for the period 2021-2022. The leading method in the study was a laboratory experiment, thanks to which, using a new advanced technology on a microbiological analyser VITEK 2 COMPACT 30, it was possible to study pathogenic and non-pathogenic strains of the genus Yersinia isolated during field experiment. As a result of experimental work, it was shown that during a long inter-epizootic period, the plague pathogen can persist in the soil in symbiosis with soil microorganisms, and in this area, it chooses soil with a low-quality index of 10 points, where soils with a low total microbial number and species landscape prevail., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)

Objective: Brachytherapy is used in 17 radiotherapy facilities In Kazakhstan. Each institution has an individual quality control (QC) program in place to ensure the safe and accurate delivery of the treatment dose to the patient. The main objective of this paper is to explore current approaches to quality control of brachytherapy in Kazakhstan and reduce potential discrepancies in testing frequency and tolerance limits by identifying a set of basic quality control requirements., Materials and Methods: A detailed brachytherapy quality control questionnaire was provided to 17 radiotherapy institutions for completion. A separate questionnaire was sent to two institutions associated with brachytherapy. Questions addressed safety aspects, radiation parameters, total time spent on quality control, and available imaging systems for dose determination. The results of the survey were compared with the recommendations set found in international brachytherapy quality control documents., Results: The results of the questionnaires revealed significant differences in the frequency and methods of testing. For example, only two of the 17 centers have at least some kind of quality assurance program for brachytherapy treatment. Only five centers have equipment with the help of which dosimetric control can be performed, and only two centers have local medical physicists performing this control. One of the centers is checked quarterly, while the other is checked only once a year. In the remaining 15 centers, dosimetric control is performed by specialists who recharge the source without providing any document or protocol. There were also significant differences in the amount of time spent on quality control, mostly related to the variety of approaches to quality control and differences in the availability of resources. Almost all centers (15 of 17) rely only on inspections from the radionuclide source supplier and do not monitor the dosimetric and mechanical parameters of the facility at all., Conclusion: Based on the results of the survey and comparison with international recommendations, a set of basic requirements for brachytherapy quality control is needed.

Workfare programs (WPs) in low- and middle-income countries have become a primary instrument to fight poverty associated with temporary economic shocks or to create a pathway out of chronic poverty. In this paper, we examine the design and implementation of a WP in Kazakhstan. We do so by executing a cost effectiveness analysis (CEA) and performing a case study analysis which investigates how the implementation process unfolded and what factors shaped it most. We find that the high cost per unit of current benefit of Kazakhstan's WP is, in part, the result of benefit 'leakage' to the non-poor, high levels of informal labor, and means-testing applicants. Furthermore, overly bureaucrat requirements of official residency and household asset documents, poor staff training because of high staff turnover, staff not following standardized procedures because of low wages and corruption, and central government KPIs resulted in "creaming" of the best applicants and improper blending with other active labor market policies. Our findings provide important lessons, such as (1) formal restrictions on eligibility lead to expensive means-testing of applicants and (2) official residency and household asset documents lead to "creaming" of the best applicants., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Background: Kazakhstan is developing a National Roadmap to strengthen its Infection Prevention and Control (IPC), but until recently has lacked a country-wide facility-level assessment of IPC performance gaps., Methods: In 2021, the World Health Organization (WHO)'s IPC Core Components and Minimal Requirements were assessed at 78 randomly selected hospitals across 17 administrative regions using adapted WHO tools. The study included site assessments, followed by structured interviews with 320 hospital staff, validation observations of IPC practices, and document reviews., Results: All hospitals had at least one dedicated IPC staff member, 76% had IPC staff with any formal IPC training; 95% established an IPC committee and 54% had an annual IPC workplan; 92% had any IPC guidelines; 55% conducted any IPC monitoring in the past 12 months and shared the results with facility staff, but only 9% used monitoring data for improvements; 93% had access to a microbiological laboratory for HAI surveillance, but HAI surveillance with standardized definitions and systematic data collection was conducted in only one hospital. Adequate bed spacing of at least 1 m in all wards was maintained in 35% of hospitals; soap and paper towels were available at the hand hygiene stations in 62% and 38% of hospitals, respectively., Conclusions: Existing IPC programs, infrastructure, IPC staffing, workload and supplies present within hospitals in Kazakhstan allow for implementation of effective IPC. Development and dissemination of IPC guidelines based on the recommended WHO IPC core components, improved IPC training system, and implementation of systematic monitoring of IPC practices will be important first steps towards implementing targeted IPC improvement plans in facilities., (© 2023. The Author(s).)

The skin shows the physiological condition of the body's organs and systems that prevent infections and physical damage. Throughout the ages, in folk medicine, phytotherapy was considered a primary form of treatment in all countries, including Kazakhstan, due to the abundance and availability of plant-based remedies. This paper discusses several medicinal plants that are traditionally used in the treatment of skin diseases in the Republic of Kazakhstan. The chemical composition of these plants was analyzed, with a particular focus on the biologically active basic compounds responsible for their therapeutic efficiency in treating skin ailments.

In the current paper, we present the results of Kazakh propolis investigations. Due to limited data about propolis from this country, research was focused mainly on phytochemical analysis and evaluation of propolis antimicrobial activity. uHPLC-DAD (ultra-high-pressure-liquid chromatography coupled with diode array detection, UV/VIS) and uHPLC-MS/MS (ultra-high-pressure-liquid chromatography coupled with tandem mass spectrometry) were used to phytochemical characteristics while antimicrobial activity was evaluated in the serial dilution method (MIC, minimal inhibitory concentration, and MBC/MFC, minimal bactericidal/fungicidal concentration measurements). In the study, Kazakh propolis exhibited a strong presence of markers characteristic of poplar-type propolis-flavonoid aglycones (pinocembrin, galangin, pinobanksin and pinobanskin-3-O-acetate) and hydroxycinnamic acid monoesters (mainly caffeic acid phenethyl ester and different isomers of caffeic acid prenyl ester). The second plant precursor of Kazakh propolis was aspen-poplar with 2-acetyl-1,3-di- p -coumaroyl glycerol as the main marker. Regarding antimicrobial activity, Kazakh propolis revealed stronger activity against reference Gram-positive strains (MIC from 31.3 to above 4000 mg/L) and yeasts (MIC from 62.5 to 1000 mg/L) than against reference Gram-negative strains (MIC ≥ 4000 mg/L). Moreover, Kazakh propolis showed good anti- Helicobacter pylori activity (MIC and MBC were from 31.3 to 62.5 mg/L). All propolis samples were also tested for H. pylori urease inhibitory activity (IC 50 , half-maximal inhibitory concentration, ranged from 440.73 to 11,177.24 µg/mL). In summary Kazakh propolis are potent antimicrobial agents and may be considered as a medicament in the future.

This paper gives the description of a new species of the genus Aturus Kramer, 1875 from Kazakhstan. Specimen was fixed in etanol 75%, dissected and mounted in Hoyer's medium.

Aims: This study assessed the nurses' knowledge of, skills on and attitudes toward health education among nurses working at the University Medical Center Corporate Fund (UMC) in Kazakhstan. The personal and professional factors influencing the nurses' knowledge of, skills on and attitudes toward health education were also investigated., Background: Health education is one of the nurses' fundamental responsibilities. Nurses' role in health education is critical in empowering patients and their families to live healthier lives, thus ensuring optimum health, well-being and quality of life. However, in Kazakhstan, where the nursing profession is still establishing its professional autonomy, data concerning the competence of Kazakh nurses in health education is unknown., Design: A quantitative study, specifically the cross-sectional, descriptive and correlational designs., Methods: The survey was performed at UMC in Astana, Kazakhstan. Using a convenience sampling technique, 312 nurses participated in the survey from March to August 2022. The "Nurse Health Education Competence Instrument" was used to collect data. The personal and professional characteristics of the nurses were also collected. Standard multiple regression analysis examined the personal and professional variables influencing the nurses' health education competence., Results: The respondents' average score in the "Cognitive domain," "Psychomotor domain," and "Affective-attitudinal domain" was 3.80 (SD = 0.66), 3.99 (SD = 0.58) and 4.04 (SD = 0.62), respectively. The nurses' category as a nurse, medical center, attendance to health education training/seminars in the last 12 months, provision of health education to a patient in the last week and perception of health education's significance in nursing practice were significant predictors of the nurses' health education competence contributing an approximately 24.4 %, 29.3 % and 27.1 % of the variance of the health education knowledge (R 2 = 0.273, Adjusted R 2 = 0.244), skills R 2 = 0.320, Adjusted R 2 = 0.293) and attitudes (R 2 = 0.299, Adjusted R 2 = 0.271)., Conclusions: The nurses reported high levels of health education competence (knowledge, attitudes and skills). The personal and professional factors influencing the nurses' competence in health education are essential to consider when developing interventions and healthcare policies to ensure nurses' competent provision of health education to patients., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Introduction: A 'learning healthcare system', based on electronic health records and other routinely collected healthcare data, would allow Real World Data (RWD) to be continuously fed into the system, ensuring that with every new patient treated, we know more overall about the practice of medicine. A judicious use of RWD would complement the traditional evidence from clinical research, for the benefit of all stakeholders involved in healthcare. Lack of data on disease epidemiology in Kazakhstan resonates with lower life expectancy and poorer health indicators compared to countries with analogous income per capita. Usage of primary data collection methods to fill these gaps require additional financial and human resources. Usage of big data, which is routinely collected though healthcare information systems, is considered as a competitive alternative in described circumstances., Objective: Development of the Unified National Electronic Healthcare System (UNEHS) in Kazakhstan allowed the creation of research databases to investigate epidemiology of numerous diseases. UNEHS research databases endorse extensive research activities due to a prospective follow-up, coverage of the whole Kazakhstani population and relatively lower expenses to conduct epidemiological studies. This review paper aims to introduce the content and descriptive data on research databases on population-based registries of UNEHS and to discuss opportunities and limitations of its usage., Results and Discussion: UNEHS databases include medical data on 36.4% of an adult population of Kazakhstan. Research databases presented in this paper contain critical variables that can be utilized for investigation of disease epidemiology, effectiveness of provided medical procedures and infectious disease epidemiology. A few examples accompany a detailed elaboration on the possibilities of research database utilization in epidemiological research., Conclusion: Considering numerous advantages, the UNEHS research databases are expected to greatly contribute to healthcare in Kazakhstan by providing critical data on disease epidemiology. To warrant long-term usage and high research output several concerns and limitations should be addressed as well., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Inland saline waters in Central Asia constitute an important part of steppe ecosystems, providing considerable ecological functions and ecosystem services. Here we aim to present a multi-spatial scale analysis of nutrient cycling and transport waterbird guilds, and the environmental attributes of saline-soda aquatic ecosystems in Kazakhstan. The density, biomass, and diversity of waterbird guilds was determined in the case of three nutrient cycling and transport guilds: a) net-importer (IM), b) importer-exporter (IMEX), c) net-exporter (EX), according to the Boros's guild classification method, and for several traditional feeding guilds: carnivorous, herbivorous, invertebrate eater, omnivorous and piscivorous. Our results revealed that waterbird guilds, as predictors represented by the complete waterbird community, are in close relationship with several (N = 12) environmental attributes of inland saline waters through complex trophic linkages of waterbird populations on multi-spatial scales. The density and the biomass of the EX and IMEX guilds are strongly and positively correlated (i) with the productivity metrics of habitats (e.g., CHL, GPP), indicating their trophic position, and (ii) with water depth. We found significant correlations among guild density, biomass, diversity and environmental attributes on multi-spatial scales for IMEX and EX. Our results revealed that IMEX predicts the surrounding environment of aquatic habitats, whereas EX species are substantial environmental predictors of aquatic ecosystems. However, the diversity metric had valid models only with EX. The herbivorous and omnivorous guilds, that feed chiefly on plant materials consist mainly of IMEX and EX duck species, which were positively related to grassland coverage and the shoreline development index. As a methodological result, here we present a novel approach, the guild transport index, which has more robust relationships with environmental attributes than individual guilds, thus it provides a complex evaluation of the nutrient cycling by birds between aquatic and terrestrial environments on multi-spatial scales., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: Although recommended for all member states of World Health Organization, there is no national human papillomavirus vaccination program in Kazakhstan. Furthermore, there are no studies in Kazakhstan that evaluate the mothers' perception of human papillomavirus vaccines., Objectives: This study aims to assess the knowledge and attitudes toward human papillomavirus vaccination among mothers in Kazakhstan and the factors associated with their attitudes., Design: A cross-sectional study was performed during the period of December 2021-February 2022. The STROBE guideline for cross-sectional studies was applied., Methods: Paper-based structured questionnaires were filled out by 191 mothers, 141 of whom had daughters. The attitude score was assessed as per the Likert-type scale. The Chi-square and Fisher's exact tests, with a significance value of < 0.05 were used to analyze the relationships between the characteristics of mothers and their attitude scores., Results: The following factors were significantly associated with mothers' attitudes toward human papillomavirus vaccination: a place of residence, family income, number of children, and refusal of vaccination for themselves (p < 0.005). Of all participants, only 45% of all mothers, 41% of mothers with a female, and 46% of mothers with male children had positive attitudes toward human papillomavirus vaccination. The child's gender was not a significant determinant. Overall, the level of knowledge about human papillomavirus vaccination was found to be low. The median total score is 0 out of 12 for women who have negative and neutral attitudes toward human papillomavirus vaccines. Among women who have positive attitudes toward HPV vaccines, the median score is around 3 points., Conclusion: Before the implementation of the human papillomavirus vaccination program into the Kazakhstani national vaccination calendar, comprehensive and adequate information and education campaigns are required on the national level for parents and the population in general.

The article highlights the results of a radioecological survey of the surface areas of combat boreholes at the Sary-Uzen site located on the territory of the Semipalatinsk Test Site (STS), where underground nuclear tests in these boreholes were conducted earlier. The surface areas of boreholes were examined the levels of radioactive contamination of the soil were determined. A total of 2 main groups were identified. The first group includes boreholes with radioactive contamination of the soil on the surface area. The second group includes boreholes with no radioactive contamination of the surface soil layer. The first group can be divided into boreholes with a deformation of the ground surface and without it. For each variety, depending on the specifics of the nuclear test, the characteristic features of radioactive contamination were determined. Based on the results of the survey, the ranges of specific activity values were established., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Objectives: The purpose of this study was to assess the organizational effectiveness of the introduction of a healthcare information system (electronic medical records and databases) in healthcare in Kazakhstan., Methods: The authors used a combination of 2., Methods: expert assessment and strengths, weaknesses, opportunities, and threats (SWOT) analysis. SWOT analysis is a necessary element of research, constituting a mandatory preliminary stage both when drawing up strategic plans and for taking corrective measures in the future. The expert survey was conducted using 2 questionnaires., Results: The study involved 40 experts drawn from specialists in primary healthcare in Aktobe: 15 representatives of administrative and managerial personnel (chief doctors and their deputies, heads of medical statistics offices, organizational and methodological offices, and internal audit services) and 25 general practitioners., Conclusions: The following functional indicators of the medical and organizational effectiveness of the introduction of information systems in polyclinics were highlighted: first, improvement of administrative control, followed in descending order by registration and movement of medical documentation, statistical reporting and process results, and the cost of employees' working time. There has been no reduction in financial costs, namely in terms of the costs of copying, delivery of information in paper form, technical equipment, and paper.

Hexavalent chromium (Cr(VI)), a known carcinogen, emanates from both anthropogenic and natural sources. A pilot study of the ambient Cr(VI) concentrations was conducted at the center of Aktobe which is a few kilometers away from major industrial chromium plants. Total Cr(VI) concentrations were measured in the fall and winter seasons with mean values (S.D) of 5.30 (2.16) ng/m 3 and 2.26 (1.80) ng/m 3 , respectively. Insoluble Cr(VI) levels were 4.80 (1.96) and 2.19 (1.75) ng/m 3 for the fall and winter, respectively. The total and insoluble Cr(VI) concentrations in the fall season were significantly higher than in winter, likely due to the higher rate of Cr(III) oxidation in the presence of ozone and ROS in fall compared to the rate of Cr(VI) reduction in the presence of VOCs at higher temperatures. On average, total Cr(VI) constituted 34.49% of the total Cr concentrations suggesting that the dominant valence state of Cr in the atmosphere is Cr(III). The previous reference values of exposure to Cr(VI) must be revisited by taking into account the insoluble Cr(VI) concentration since it is more prevalent in the atmosphere compared to soluble Cr(VI). The influence of the chromium plants as potential sources was not obvious in this study., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

An active surveillance study of avian influenza viruses (AIVs) in wild birds was carried out in Kazakhstan in 2018-2019. In total, 866 samples were collected from wild birds and analyzed for influenza viruses using molecular and virological tests. Genome segments of Asian, European, and Australian lineages were detected in 25 (4.6%) out of 541 waterfowl samples positive for subtype H3N8, and in two (0.6%) out of 325 H3N8 positive samples from terrestrial birds. No highly pathogenic avian influenza virus (AIV) was detected. The results indicated transmission of closely related strains or identical subtypes of AIVs by a flock-unit of migratory birds or annual cyclical pattern of subtype dominance. The simultaneous circulation of genome segments of the Asian, European and Australian genetic lineages of H3N8 AIVs in wild birds in Kazakhstan indicated the important role of Central Asia as a transmission hub of AI viruses linking the East Asian migratory flyways with European flyways and vice versa., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier B.V.)

The paper presents a review of current literature data on ongoing international studies to identify genetic predictors of schizophrenia, since heredity and family predisposition to schizophrenia have been known for several decades. New data on the interaction between genetic variants, epigenetic marks, including cross interaction between the processes of DNA methylation and histone modification, affecting the regulation of gene expression under the influence of the environment, are reflected. Particular attention is paid to studies devoted to identifying the features of genetic predictors of schizophrenia in certain ethnic populations, in particular in relation to persons of the Kazakh ethnic group in the Republic of Kazakhstan. The study was carried out within the framework of the project: "National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan" IRN OR12165486.

Kazakhstan strives to obtain Universal Health Coverage (UHC) by using health technology assessment (HTA) for determining their health benefit package. This paper reports on employing evidence-informed deliberative processes (EDPs), a practical and stepwise approach to enhance legitimate health benefit package design in Kazakhstan., Methods: The Ministry of Health of Kazakhstan approved the operationalization and application of EDPs during March 2019 and December 2020. We used a combination of desk research, conducting HTA, online surveys as well as a face-to-face workshop in Nur-Sultan, Kazakhstan, and two online workshops to prioritize 25 selected health technologies. During the latter, we tested two alternative approaches to prioritization: quantitative multicriteria decision analysis (MCDA) and the use of decision rules., Results: For each of the HTA reports, evidence summaries were developed according to the decision criteria (safety, social priority disease, severity of disease, effectiveness, cost-effectiveness, level of evidence, financial risk protection and budget impact). When appraising the evidence, the advisory committee preferred using quantitative MCDA, and only when this would result in any controversy could decision rules be applied., Conclusions: Despite several challenges, including a partial disruption because of the COVID-19 pandemic, implementation of the process will likely play a key role in determining an evidence-informed and transparent health benefit package.

Introduction: Punitive legal environments remain a challenge to HIV prevention efforts in Central Asia, and female sex workers who use drugs are vulnerable to police violence. Little is known about the heterogeneity of police violence against female sex workers who use drugs and factors associated with HIV risk in Central Asia, despite the growing HIV epidemic., Methods: We recruited a community-based sample of 255 female sex workers who use drugs in Almaty, Kazakhstan between February 2015 and May 2017. We used latent class analysis to differentiate women into distinct classes of police violence victimization, and multinomial logistic regression to identify individual-level health outcomes, HIV risk behaviors, and social and structural factors within the risk environment associated with class membership., Results: A three-class model emerged: Low Victimization (51%), Discrimination and Extortion (15%), and Poly-Victimization (34%). Relative to Low Victimization, factors associated with Poly-Victimization included being positive for HIV and/or sexually-transmitted infections (STI) (aOR: 1.78 (95% CI: 1.01, 3.14)), prior tuberculosis diagnosis (2.73 (1.15, 6.50)), injection drug use (IDU) (2.00 (1.12, 3.58)), greater number of unsafe IDU behaviors (1.21 (1.08, 1.35)), homelessness (1.92 (1.06, 3.48)), greater drug use (1.22 (1.07, 1.39)) and sex work stigma (1.23 (1.06, 1.43)), greater number of sex work clients (2.40 (1.33, 4.31)), working for a boss/pimp (2.74 (1.16, 6.50)), client violence (2.99 (1.65, 5.42)), economic incentives for condomless sex (2.77 (1.42, 5.41)), accessing needle/syringe exchange programs (3.47 (1.42, 8.50)), recent arrest (2.99 (1.36, 6.55)) and detention (2.93 (1.62, 5.30)), and negative police perceptions (8.28 (4.20, 16.3)). Compared to Low Violence, Discrimination and Extortion was associated with lower odds of experiencing intimate partner violence (aOR= 0.26 (0.12, 0.59)), but no other significant associations with the risk environment upon adjusting for socio-demographic characteristics., Conclusion: Police violence against female sex workers who use drugs is pervasive in Kazakhstan. Patterns of police violence vary, with greater HIV susceptibility associated with a higher probability of experiencing multiple forms of police violence. Police sensitization workshops that integrate policing and harm reduction, and drug policy reforms that decriminalize drug use may help mitigate the HIV epidemic in Kazakhstan., Competing Interests: Declarations of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Cervical cancer remains one of the top causes of cancer-related morbidity and mortality all over the world. Currently, however, there are no published studies to assess the knowledge of HPV and cervical cancer in Kazakhstan. This study aimed to assess the awareness of HPV, the knowledge of HPV as a cause of cervical cancer, and the awareness of HPV vaccination among Kazakhstani women visiting gynecological clinics across the country. In addition, the study aimed to identify the factors associated with the awareness of HPV and the HPV vaccine and knowledge of HPV as a major cause of cervical cancer. This was a cross-sectional survey-based study with 2,272 women aged between 18-70 years attending gynecological clinics, who were administered paper-based questionnaires. Data analysis included descriptive statistics consisting of mean values, standard deviations, and frequencies, where applicable. Differences in categorical variables between groups were analyzed using the Chi-square test with a significance value of <0.005. Crude odds ratio (OR) and adjusted odds ratio (AOR) with 95% corresponding confidence intervals were calculated in regression analysis using univariate and multivariable logistic regression models. The mean age of participants was 36.33±10.09 years. More than half (53%) of the participants had been screened for cervical cancer. Among those who were aware of HPV, 46% knew that HPV causes cervical cancer and 52% were aware of the HPV vaccine. The key factors related to outcome variables were age, ethnicity, education, family, number of deliveries, and menarche. From a subgroup analysis, results from the HPV test and Pap smear test were factors related to dependent variables such as awareness of HPV and awareness of HPV vaccination., Competing Interests: The authors have declared that no competing interests exist.

In pan Pamir Plateau countries, Peste des petits ruminants (PPR) has brought huge losses to the livestock industry and threaten the endangered wildlife. In unknown regions, revealing PPRV transmission among countries is the premise of effective prevention and control, therefore calls for quantified monitoring on disease communication among countries. In this paper, a MaxEnt model was built for the first time to predict the PPR risk within the research area. The least cost path (LCP) for PPR transboundary communication were calculated and referred to as the maximum available paths (MAP). The results show that there are many places with high-risk in the research area, and the domestic risk in China is lower than that in foreign countries and is mainly determined by human activities. Five LCPs representing corridors among Kazakhstan, Tajikistan, Pakistan, India and China were obtained. This study proves for the first time that there is the possibility of cross-border transmission of diseases by wild and domestic animals. In the future, it will play an important role in monitoring the PPR epidemic and blocking-up its cross-border transmission., Competing Interests: The authors have declared that no competing interests exist.

Safe water and sanitation, which give rise to appropriate hygiene, are fundamental determinants of individual and social health and well-being. Thereby, assessing and widening access to sustainable, durable water and sanitation infrastructure remains a global health issue. Rural areas are already at a disadvantage. Poor access to water, sanitation, and hygiene (WASH) can have a major negative effect on students in rural schools. Thus, the paper aims to assess the current condition and the challenge to access WASH in rural Kazakh schools. The study was conducted in three rural schools in Central Kazakhstan. Data were gathered through a survey among pupils, observations of the WASH infrastructure and maintenance, and a face-to-face interview with school administrators. The mean survey response rate was 65% across schools. Results indicated there was no alternative drinking-water source in schools, and 15% of students said they had access to water only occasionally. Half of the students reported that the water was unsafe to drink because of a poor odor, taste, or color. The toilet in school 3 was locked with a key, and a quarter of the students reported there was no access to a key. Moreover, not having gender-separated toilet facilities was a challenge because of the traditional gender norms. Despite the effective regulations and measures of handwashing taken during COVID-19, 27.7% of the students answered that soap was not offered daily in classrooms. Additionally, warm water was only provided in school 2. About 75% of students did not have access to drying materials continuously. The study shows that having the schools' infrastructure is not enough when characteristics, such as availability, accessibility, maintenance, operation, quality of services, education, and practices, are ignored. Cooperation between local education authorities, school administration, and parents should be encouraged to the achievement of the sustainable development goals (SDGs) by 2030.

In developed countries, the ideas of ecological agricultural production, continuous cycle, and waste-free production technologies have gained popularity. The effect from the production and consumption of ecological agricultural products is determined by the least harm to the environment, increasing the competitiveness of products, and receiving additional profit from increasing prices for higher quality products. The production of organically safe products is based on the principle of biologization, i.e., the widespread use of biological preparations, a high proportion of legumes (sources of nitrogen), and avoiding chemical plant protection products, transgenic plants, and genetically modified organisms (GMOs). This study aims to increase the productivity of safflower and improve the physicochemical and biological indicators of dark chestnut soils through the use of biologized technologies in the organic farming system. Standard methods for assessment and statistical analysis of physical and chemical parameters of soils were carried out in zone 1 of West Kazakhstan. This made it possible to identify the most optimal technology for the cultivation of safflower. The study results showed that under the influence of the phytomeliorative action of safflower in the 0-20 cm layer of dark chestnut soils, one could note an increase in the content of nitrate nitrogen by 5.95%, an increase in the content of mobile phosphorus by 5.22%, and soil loosening by 0.010 g/cm 3 , with the structure of the soil being 64.43%. Strong biological activity of the soil was established by the crops of safflower. The highest yield of safflower oil about 0.23 t/ha with an oil content of 30.1% was obtained using the biologized technology option. The use of biological technology, along with biological yields, increases oil yield by 0.06 t/ha or 28.06%., Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper., (Copyright © 2021 Beybit Nasiyev et al.)

Radiocarbon ( 14 C) is a unique and important tool for understanding carbon cycle in the nature, and its use can be significantly enhanced where reliable historical atmospheric Δ 14 CO 2 records can be established. In China, continuous atmospheric Δ 14 CO 2 records since the 1950s are scarce, a period when dramatic variations of Δ 14 CO 2 occurred caused by intensive human activities. In this research, Δ 14 C of Qinghai spruce tree rings collected from Huangzhong (HZ) (36.27°N, 101.67°E, 2982 m amsl) were measured by Accelerator Mass Spectrometry, and a Δ 14 CO 2 time series from 1957 to 2015 was reconstructed. The results show that HZ Δ 14 C was generally higher than the contemporaneous average level in the mid-high latitudes of the Northern Hemisphere. The peak value of HZ Δ 14 C occurred in 1964 (as bomb peak) was higher than that of other tree ring records in East Asia at a similar latitude, likely due to the impact of the atmosphere nuclear tests at Semipalatinsk (Kazakhstan). The record shows no obvious disturbance of Lop Nor nuclear weapons tests (in Northwest China) during 1964-1980, except for 1971. A local Suess effect began to appear since 2001, and the estimated atmospheric fossil fuel-derived CO 2 (CO 2ff ) concentration increased from 3.5 ppm to 8.8 ppm from 2006 to 2015. This is associated with the implementation of the "Western Development" strategy in China. HZ Δ 14 C records document background Δ 14 C data, useful for regional carbon cycle research and atmospheric CO 2ff quantification in the region. These data also provide baseline values for assessment environmental safety connected with nuclear power plants in China., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Introduction: Female sex workers (FSW) who use drugs are a key population at risk of HIV in Kazakhstan, and face multiple structural barriers to HIV prevention. More research is needed on the role of structural interventions such as microfinance (MF) in reducing HIV risk. This paper describes the results of a cluster-randomized controlled trial to test the efficacy of a combination HIVRR + MF intervention in reducing biologically confirmed STIs and HIV risk behaviours., Methods: This study took place from May 2015 to October 2018 in two cities in Kazakhstan. We screened 763 participants for eligibility and enrolled 354 FSW who use drugs. Participants were randomized in cohorts to receive either a four-session HIVRR intervention, or that same intervention plus 30 additional sessions of financial literacy training, vocational training and asset-building through a matched-savings programme. Repeated behavioural and biological assessments were conducted at baseline, 3-, 6- and 12-months post-intervention. Biological and behavioural primary outcomes included HIV/STI incidence, sexual risk behaviours and drug use risk behaviours, evaluated over the 12-month period., Results: Over the 12-month follow-up period, few differences in study outcomes were noted between arms. There was only one newly-detected HIV case, and study arms did not significantly differ on any STI incidence. At post-intervention assessments compared to baseline, both HIVRR and HIVRR + MF participants significantly reduced sexual and drug use risk behaviours, and showed improvements in financial outcomes, condom use attitudes and self-efficacy, social support, and access to medical care. In addition, HIVRR + MF participants showed a 72% greater reduction in the number of unprotected sex acts with paying partners at the six-month assessment (IRR = IRR = 0.28, 95% CI = 0.08, 0.92), and a 10% greater reduction in the proportion of income from sex work at the three-month assessment (b = -0.10, 95% CI = -0.17, -0.02) than HIVRR participants did. HIVRR + MF participants also showed significantly improved performance on financial self-efficacy compared to HIVRR over the 12-month follow-up period., Conclusions: Compared to a combination HIVRR + MF intervention, a robust HIVRR intervention alone may be sufficient to reduce sexual and drug risk behaviours among FSW who use drugs. There may be structural limitations to the promise of microfinance for HIV risk reduction among this population., (© 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.)

A detailed characterization of municipal solid waste (MSW) beyond a standard compositional analysis may offer insights useful for improving waste management systems. The present paper contributes to the scarce literature in the field by presenting new data from a rapidly developing Central Asian city, the capital of Kazakhstan, Nur-Sultan. Three sampling campaigns (each 1 week long) have been conducted at the city landfill over a 1-year period (2018-2019), and a detailed characterization for selected waste components and sub-components has been performed. The major fractions of MSW were organics (46.3%), plastics (15.2%), paper (12.8%), and diapers (5.9%). The detailed composition analysis showed high LDPE (low-density polyethylene) content (5.5%) mostly comprised of plastic bags (4.5%), transparent glass (3.2%), pharmaceuticals (0.4%), and fine (i.e., < 12 mm) organic fraction content (29%). The MSW generation rate of Nur-Sultan was estimated as 1.47 kg capita -1  day -1 based on the field collection as well as literature data. Among sustainable waste management recommendations addressed for Nur-Sultan and applicable to other cities in Central Asia, composting is recommended due to high organics fraction in MSW and its great potential to reduce the landfilled waste volume and to help valorizing the waste.

This paper describes a new genus of the water mite family Hydryphantidae. The material was collected by V. Stolbov in 2019 in running waters in Kazakhstan. The material was sampled with a common hand net with 250 µm mesh size. The water mites were fixed in 75% ethanol.

Lagged precipitation effect explains a large proportion of annual aboveground net primary productivity in some dryland ecosystems. Using satellite-derived plant productivity and precipitation datasets in the Northern Hemisphere drylands during 2000-2018, we identify 1111 pixels mainly located in the Tibetan Plateau, the western US, and Kazakhstan where productivities are significantly correlated with previous-year precipitation (hereafter, the lagged type). Differences in climatic and edaphic factors between the lagged and unlagged (pixels where productivities are not correlated with previous-year precipitation) types are evaluated. Permutational multivariate analysis of variance shows that the two types differ significantly regarding six climatic and edaphic factors. Compared to unlagged type, water availability, soil organic carbon, total nitrogen, field capacity, silt content and radiation are more sensitive to changes in precipitation in lagged type. Water availability is the most important factor for distinguishing the two types, followed by soil organic carbon, total nitrogen, field capacity, soil texture, and radiation. Our study suggests that the altered sensitivities of several climatic and edaphic factors to precipitation collectively affect the lagged effect of precipitation on productivity in drylands., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Petrochemical enterprises in Kazakhstan discharge polluted wastewater into special recipients. Contaminants infiltrate through the soil into the groundwater, which potentially affects public health and environment safety. This paper presents the evaluation of a 7-year monitoring program from one of the factories and includes nineteen variables from nine wells during 2013-2019. Several multivariate statistical techniques were used to analyse the data: Pearson's correlation matrix, principal component analysis and cluster analysis. The analysis made it possible to specify the contribution of each contaminant to the overall pollution and to identify the most polluted sites. The results also show that concentrations of pollutants in groundwater exceeded both the World Health Organization and Kazakhstani standards for drinking water. For example, average exceedance for total petroleum hydrocarbons was 4 times, for total dissolved solids-5 times, for chlorides-9 times, for sodium-6 times, and total hardness was more than 6 times. It is concluded that host geology and effluents from the petrochemical industrial cluster influence the groundwater quality. Heckman two-step regression analysis was applied to assess the bias of completed analysis for each pollutant, especially to determine a contribution of toxic pollutants into total contamination. The study confirms a high loading of anthropogenic contamination to groundwater from the petrochemical industry coupled with natural geochemical processes.

In the present study, the daily dose in terms of particle surface area received by citizens living in different low- and middle-income countries, characterized by different lifestyles, habits, and climates, was evaluated. The level of exposure to submicron particles and the dose received by the populations of Accra (Ghana), Cairo (Egypt), Florianopolis (Brazil), and Nur-Sultan (Kazakhstan) were analyzed. A direct exposure assessment approach was adopted to measure the submicron particle concentration levels of volunteers at a personal scale during their daily activities. Non-smoking adult volunteers performing non-industrial jobs were considered. Exposure data were combined with time-activity pattern data (characteristic of each population) and the inhalation rates to estimate the daily dose in terms of particle surface area. The received dose of the populations under investigation varied from 450 mm 2 (Florianopolis, Brazil) to 1300 mm 2 (Cairo, Egypt). This work highlights the different contributions of the microenvironments to the daily dose with respect to high-income western populations. It was evident that the contribution of the Cooking & Eating microenvironment to the total exposure (which was previously proven to be one of the main exposure routes for western populations) was only 8%-14% for low- and middle-income populations. In contrast, significant contributions were estimated for Outdoor day and Transport microenvironments (up to 20% for Cairo, Egypt) and the Sleeping & Resting microenvironment (up to 28% for Accra, Ghana), highlighting the effects of different site-specific lifestyles (e.g. time-activity patterns), habits, socioeconomic conditions, climates, and outdoor air quality., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

In this paper, we briefly described the ecological consequences of six space rocket accidents launched from the Baikonur Cosmodrome between 1999 and 2018 and focused on an assessment of efficiency of soil remediation following the accidental crash of launch vehicle Proton-M on July 2, 2013, which resulted in the severest environmental impact in the modern Russian space industry. On the day after the accident, the content of carcinogenic unsymmetrical dimethylhydrazine and nitrosodimethylamine, as well as nitrate in soils of the crash site exceeded their maximal permissible concentrations by 8900, 6100 and 85 times, respectively. Mitigation measures included soil detoxication by a solution of 10% H 2 O 2 and 1% iron complexonate, soil excavation and ploughing. Two years later (in April 2015), both unsymmetrical dimethylhydrazine and nitrosodimethylamine concentrations were below 0.05 mg/kg and nitrate concentration did not exceed 3.9 g/kg. As compared to background sites, soils of the crash site had significantly (P-value<0.05) lower values of pH and the content of total organic carbon, basicity from soda and carbonates and higher total nitrogen and soluble salt contents. Soil microbial communities were the most vulnerable component of the disturbed arid ecosystems, as their suppressed condition was indicated by a low biochemical oxygen demand and a very low cellulase activity., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Objective: Although cervical cancer could be prevented through medical screening, it remains one of the top causes of cancer-related morbidity and mortality all over the world. A number of factors may contribute to cervical cancer screening behaviour of women. The aim of this study was to investigate factors related to cervical cancer screening behaviour of women in Kazakhstan., Methods: This was a cross-sectional survey-based study with a total of 1189 participants. Women attending gynaecological clinics aged between 18 and 70 years were administered paper-based questionnaires about their awareness of cervical cancer, the associated risk factors, and cervical cancer screening. Student t test or Wilcoxon rank-sum test and chi-square test or Fisher's exact test, where appropriate, were used to determine associations with categorical independent variables., Results: The mean age of participants was 36.5 ± 10.1 years. Less than half (45.7%) of the participants had been screened for cervical cancer. The key factors related to the cervical cancer screening behaviour of women in this study included age, having a larger number of children, regular menstrual function, awareness of Pap smear test, and free screening programme for cervical cancer, and the causal association of human papillomavirus with cervical cancer., Conclusion: This study revealed several significant factors predicting screening behaviour in Kazakhstani women. To improve the rate of screening, there is a need to increase public knowledge and awareness of cervical cancer and opportunities for the free screening programme in the female population of Kazakhstan.

Trace elements (TEs) in the insoluble particles of surface snow are less affected by melting processes and can be used as environmental proxies to reveal natural and anthropogenic emissions. Here the first comprehensive study of the 16 TEs (Al, As, Ba, Bi, Cr, Cu, Fe, Mn, Ni, Pb, Sn, Sr, Ti, U, V, and Zn) in insoluble particles (>0.45 μm) from surface snow samples collected at Urumqi Glacier No. 1 (UG1), Eastern Tien Shan, China, from February 2008 to January 2010 were presented. Results show that concentrations of most insoluble particulate TEs (TEs insol ) in the snow were higher in summer while lower in winter, due to the increasing particle inputs and melting processes. The abundances of As, Cr, Cu, Ni, Pb, and Zn in some samples were higher than those in surrounding urban soils, which might due to these TEs have further anthropogenic input beyond the already contaminated re-suspended urban soil particles and TEs were mainly enriched in particles with small grain size. Based on enrichment factor (EF) and principal component analysis (PCA), our results suggest that eight TEs (Al, Fe, Ti, Ba, Mn, Sr, U, and V) mainly came from mineral dust, while the remaining eight TEs (As, Bi, Cr, Cu, Ni, Pb, Sn, and Zn) were affected by coal combustion, mining and smelting of non-ferrous metals, traffic emissions, and the steel industry. The Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model suggests that pollutants might originate from Xinjiang province, Kazakhstan, and Kyrgyzstan. Moreover, UG1 received more significant inputs of particle-bound pollutants in summer than in winter due to the stronger convection and the prevailing valley wind that transports pollutants from the city of Urumqi., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)