1. A new method for the encapsulation of mammalian cells.
- Author
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Merten OW, Dautzenberg H, and Palfi GE
- Subjects
- Animals, Antibodies, Monoclonal analysis, Antibodies, Monoclonal biosynthesis, Capsules, Cell Line, Cellulose analogs & derivatives, Culture Techniques methods, Hybridomas immunology, Immunoglobulin G analysis, Immunoglobulin G biosynthesis, Mice, Polymers, Hybridomas physiology, Polyethylenes, Quaternary Ammonium Compounds
- Abstract
A new encapsulation method was developed for the cultivation of mammalian cells. The capsules were produced using a solution of sodium cellulose sulphate (CS)(1.5%) and poly-dimethyl-diallyl-ammonium chloride (PDMDAAC). When CS droplets fell into the precipitation bath consisting of a 2% solution of PDMDAAC, immediately a membrane at the interphase was built up. The influences of varying encapsulation process parameters on capsule characteristics, cell growth, and monoclonal antibody production were tested. This new method showed advantages when compared to other methods mainly due to time simplicity of the whole process.
- Published
- 1991
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