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20 results on '"Whisstock, James C."'

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1. The structural basis for membrane binding and pore formation by lymphocyte perforin

2. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

3. Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

4. Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

5. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

6. A common fold mediates vertebrate defense and bacterial attack

7. The major human and mouse granzymes are structurally and functionally divergent

8. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

9. Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(sub)1-antitrypsin to inhibit cathepsin proteases

10. Probing the role of the F-helix in Serpin stability through a single tryptophan substitution

11. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

12. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage

13. COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity

14. Functional insights from the distribution and role of homopeptide repeat-containing proteins

15. Importance of the prime subsites of the Cls protease of the classical complement pathway for recognition of substrates

16. Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site difference between different forms

17. Introduction of a mutation in the shutter region of antithrombin (Phe77 to Leu) increases affinity for heparin and decreases thermal stability

18. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

19. RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins

20. Serpins' mystery solved: polymers of misfolded proteins underlie many diseases, including major neurodegenerative disorders. Structural data on how such aggregates of serpin proteins form answer several outstanding questions

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