Back to Search Start Over

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

Authors :
Al-Khunaizi, May
Luke, Cliff J.
Askew, Yuko S.
Pak, Stephen C.
Askew, David J.
Cataltepe, Sule
Miller, David
Mills, David R.
Tsu, Christopher
Bromme, Dieter
Irving, James A.
Whisstock, James C.
Silverman, Gary A.
Source :
Biochemistry. March 5, 2002, Vol. 41 Issue 9, p3189, 11 p.
Publication Year :
2002

Abstract

The mouse SQN-5 serpin inhibits both chymotrypsin-like serine and the papain-like cysteine proteinases through a reactive site loop-dependent inhibitory mechanism. Data indicate that the human and mouse serpin genes seem to have originated from a common ancestor.

Details

ISSN :
00062960
Volume :
41
Issue :
9
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.83988618