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1. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP

Author

Jiandie Lin, Ruojing Yang, Pei-Hsuan-Wu, Handschin, Christoph, Wenli Yang, Siming Li, Tarr, Paul T., Newguard, Christopher B., Tontonoz, Peter, Uldry, Marc, Spiegelman, Bruce M., and Liming Pei

Subjects
Protein binding -- Research, Hyperlipidemia -- Research, Biological sciences
Abstract

High-fat feeding that induces hyperlipidemia and antherogenesis, stimulates the expression of both PGC-1 beta and sterol responsive element binding protein (SREBP)1c and 1a in liver is described. Unlike SREBP itself, PGC-1beta reduces fat accumulation in the liver while greatly increasing circulating triglycerides and cholesterol in VLDL particles.

Published
2005

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