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Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
- Source :
- Cell. Jan 28, 2005, Vol. 120 Issue 2, p261, 13 p.
- Publication Year :
- 2005
-
Abstract
- High-fat feeding that induces hyperlipidemia and antherogenesis, stimulates the expression of both PGC-1 beta and sterol responsive element binding protein (SREBP)1c and 1a in liver is described. Unlike SREBP itself, PGC-1beta reduces fat accumulation in the liver while greatly increasing circulating triglycerides and cholesterol in VLDL particles.
- Subjects :
- Protein binding -- Research
Hyperlipidemia -- Research
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 120
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.133173742