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9 results on '"Lammas, David"'

1. A mycolic acid--specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

Author

Montamat-Sicotte, Damien J., Millington, Kerry A., Willcox, Carrie R., Hingley-Wilson, Suzie, Hackforth, Sarah, Innes, John, Kon, Onn Min, Lammas, David A., Minnikin, David E., Besra, Gurdyal S., Willcox, Benjamin E., and Lalvani, Ajit

Subjects
Lipids -- Health aspects, T cells -- Health aspects, Tuberculosis vaccines -- Health aspects, Immune response -- Health aspects, Tuberculosis -- Health aspects, Health care industry
Abstract

Current tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M. tuberculosis) is essential [...]

Published
2011
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2. The 5-deoxy-5-methylthio-xylofuranose residue in mycobacterial lipoarabinomannan: Absolute stereochemistry, linkage position, conformation, and immunomodulatory activity

Author

Joe, Maju, Sun, Daniel, Taha, Hashem, Completo, Gladys C., Croudace, Joanne E., Lammas, David A., Besra, Gurdyal S., and Lowary, Todd L.

Subjects
Mycobacteria -- Research, Mycobacterium -- Research, Methyl groups -- Chemical properties, Furans -- Chemical properties, Sugars -- Research, Chemistry
Abstract

The synthesis of a panel of 5-deoxy-5-methylthio-xylofuranose (MTX)- and 5-deoxy-5-methylsulfoxy-xylofuranose-containing disaccharides was described. Two of the synthesized disaccharides, when tested in assays of cytokine induction did not lead to production of TNF-alpha however, both showed modest inhibitory properties when these cytokines were induced.

Published
2006

3. Pyogenic bacterial infections in humans with IRAK-4 deficiency. (Reports)

Author

Picard, Capucine, Puel, Anne, Bonnet, Marion, Ku, Cheng-Lung, Bustamante, Jacinta, Yang, Kun, Soudais, Claire, Dupuis, Stephanie, Feinberg, Jacqueline, Fieschi, Claire, Elbim, Carole, Hitchcock, Remi, Lammas, David, Davies, Graham, Ghonaium, Abdulaziz al-, Rayes, Hassan al-, Jumaah, Sulaiman al-, Hajjar, Sami al-, Mohsen, Ibrahim Zaid al-, Frayha, Husn H., Rucker, Rajivi, Hawn, Thomas R., Aderem, Alan, Tufenkeji, Haysam, Haraguchi, Soichi, Day, Noorbibi K., Good, Robert A., Gougerot-Pocidalo, Marie-Anne, Ozinsky, Adrian, and Casanova, Jean-Laurent

Subjects
Children -- Diseases -- Research, Immunity -- Research, Gram-positive bacterial infections -- Prevention -- Research, Interleukin-1 -- Research, Science and technology, Diseases, Prevention, Research
Abstract

Members of the Toll-like receptor (TIR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. We describe three unrelated children with inherited IRAK-4 deficiency. Their blood and fibroblast cells did not activate nuclear factor KB and mitogen-activated protein kinase (MAPK) and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. The otherwise healthy children developed infections caused by pyogenic bacteria. These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms., The members of the mammalian Toll-like/ interleukin-1 receptor superfamily characteristically have a TIR domain (1). This superfamily contains two classes of membrane receptors: TLRs, seven of which recognize known ligands [...]

Published
2003

4. Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds

Author

Picard, Capucine, Fieschi, Claire, Altare, Frederic, Al-Jumaah, Suliman, Al-Hajjar, Sami, Feinberg, Jacqueline, Dupuis, Stephanie, Soudais, Claire, Al-Mohsen, Ibrahim Zaid, Genin, Emmanuelle, Lammas, David, Kumararatne, Dinakantha S., Leclerc, Tony, Rafii, Arash, Frayha, Husn, Murugasu, Belinda, Wah, Lee Bee, Sinniah, Raja, Loubser, Michael, Okamoto, Emi, Al-Ghonaium, Abdulaziz, Tufenkeji, Haysam, Abel, Laurent, and Casanova, Jean-Laurent

Subjects
Interleukin-12 -- Research, Human genetics -- Research, Mycobacterial infections -- Genetic aspects, Biological sciences
Published
2002

5. Revisiting human IL-12R(beta)1 deficiency: a survey of 141 patients from 30 countries

Author

de Beaucoudrey, Ludovic, Samarina, Arina, Bustamante, Jacinta, Cobat, Aurelie, Boisson-Dupuis, Stephanie, Feinberg, Jacqueline, Al-Muhsen, Saleh, Janniere, Lucile, Rose, Yoann, de Suremain, Maylis, Kong, Xiao-Fei, Filipe-Santos, Orchidee, Chapgier, Ariane, Picard, Capucine, Fischer, Alain, Dogu, Figen, Ikinciogullari, Aydan, Tanir, Gonul, Al-Hajjar, Sami, Al-Jumaah, Suliman, Frayha, Husn H., AlSum, Zobaida, Al-Ajaji, Sulaiman, Alangari, Abdullah, Al-Ghonaium, Abdulaziz, Adimi, Parisa, Mansouri, Davood, Ben-Mustapha, Imen, Yancoski, Judith, Garty, Ben-Zion, Rodriguez-Gallego, Carlos, Caragol, Isabel, Kutukculer, Necil, Kumararatne, Dinakantha S., Patel, Smita, Doffinger, Rainer, Exley, Andrew, Jeppsson, Olle, Reichenbach, Janine, Nadal, David, Boyko, Yaryna, Pietrucha, Barbara, Anderson, Suzanne, Levin, Michael, Schandene, Liliane, Schepers, Kinda, Efira, Andre, Mascart, Francoise, Matsuoka, Masao, Sakai, Tatsunori, Siegrist, Claire-Anne, Frecerova, Klara, Bluetters-Sawatzki, Renate, Bernhoft, Jutta, Freihorst, Joachim, Baumann, Ulrich, Richter, Darko, Haerynck, Filomeen, De Baets, Frans, Novelli, Vas, Lammas, David, Vermylen, Christiane, Tuerlinckx, David, Nieuwhof, Chris, Pac, Malgorzata, Haas, Walther H., Muller-Fleckenstein, Ingrid, Fleckenstein, Bernhard, Levy, Jacob, Raj, Revathi, Cohen, Aileen Cleary, Lewis, David B., Holland, Steven M., Yang, Kuender D., Wang, Xiaochuan, Wang, Xiaohong, Jiang, Liping, Yang, Xiqiang, Zhu, Chaomin, Xie, Yuanyuan, Lee, Pamela Pui Wah, Chan, Koon Wing, Chen, Tong-Xin, Castro, Gabriela, Natera, Ivelisse, Codoceo, Ana, King, Alejandra, Bezrodnik, Liliana, Di Giovani, Daniela, Gaillard, Maria Isabel, de Moraes-Vasconcelos, Dewton, Grumach, Anete Sevciovic, da Silva Duarte, Alberto Jose, Aldana, Ruth, Espinosa-Rosales, Francisco Javier, Bejaoui, Mohammed, Bousfiha, Ahmed Aziz, El Baghdadi, Jamila, Ozbek, Namik, Aksu, Guzide, Keser, Melike, Somer, Ayper, Hatipoglu, Nevin, Aydogmus, Cigdem, Asilsoy, Suna, Camcioglu, Yildiz, Gulle, Saniye, Ozgur, Tuba T., Ozen, Meteran, Oleastro, Matias, Bernasconi, Andrea, Mamishi, Setareh, Parvaneh, Nima, Rosenzweig, Sergio, Barbouche, Ridha, Pedraza, Sigifredo, Lau, Yu Lung, Ehlayel, Mohammad S., Fieschi, Claire, Abel, Laurent, Sanal, Ozden, and Casanova, Jean-Laurent

Subjects
Interleukin-12 -- Physiological aspects, Interleukin-12 -- Abnormalities, Mycobacterial infections -- Risk factors, Mycobacterial infections -- Distribution, Mycobacterial infections -- Surveys, Disease susceptibility -- Surveys, Mendel's law -- Analysis, Company distribution practices
Published
2010

6. Association of a polymorphism in the [P2X.sub.7] gene with tuberculosis in a Gambian population

Author

Li, Cheuk M., Campbell, Sarah J., Kumararatne, Dinakantha S., Bellamy, Richard, Ruwende, Cyril, McAdam, Keith P. W. J., Hill, Adrian V. S., and Lammas, David A.

Subjects
Genetic polymorphisms -- Physiological aspects, Tuberculosis -- Genetic aspects, Tuberculosis -- Demographic aspects, Mycobacterium tuberculosis -- Physiological aspects, Bacteriology, Medical -- Research, Health
Published
2002

7. Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

Author

MacLennan, Calman, Fieschi, Claire, Lammas, David A., Picard, Capucine, Dorman, Susan E., Sanal, Ozden, MacLennan, Jenny M., Holland, Steven M., Ottenhoff, Tom H.M., Casanova, Jean-Laurent, and Kumararatne, Dinakantha S.

Subjects
Salmonella -- Care and treatment, Interleukin-1 -- Dosage and administration, Cytokines -- Research, Health
Published
2004

8. Clinical features of dominant and recessive interferon g receptor 1 deficiencies

Author

Dorman, Susan E., Picard, Capucine, Lammas, David, Heyne, Klaus, van Dissel, Jaap T., Baretto, Richard, Rosenzweig, Sergio D., Newport, Melanie, Levin, Michael, Roesler, Joachim, Kumararatne, Dinakantha, Casanova, Jean-Laurent, and Holland, Steven M.

Subjects
Communicable diseases -- Diagnosis, Communicable diseases -- Care and treatment, Interferon -- Research
Published
2004

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