A mycolic acid--specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

Authors :: Montamat-Sicotte, Damien J.
Millington, Kerry A.
Willcox, Carrie R.
Hingley-Wilson, Suzie
Hackforth, Sarah
Innes, John
Kon, Onn Min
Lammas, David A.
Minnikin, David E.
Besra, Gurdyal S.
Willcox, Benjamin E.
Lalvani, Ajit
Source :: Journal of Clinical Investigation. June 1, 2011, Vol. 121 Issue 6, p2493, 11 p.
Publication Year :: 2011
Abstract: Current tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M. tuberculosis) is essential [...]

Subjects :: Health aspects
Tuberculosis vaccines -- Health aspects
Lipids -- Health aspects
Tuberculosis -- Health aspects
Immune response -- Health aspects
T cells -- Health aspects

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