1. Thin-film microbiosensors for glucose-lactate monitoring
- Author
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Jobst, Gerhard, Moser, Isabella, Varahram, Mehdi, Svasek, Peter, Aschauer, Elmar, Trajanoski, Zlatko, Wach, Paul, Kotanko, Peter, Skrabal, Falko, and Urban, Gerald
- Subjects
Biosensors -- Design and construction ,Thin films -- Usage ,Chemistry - Abstract
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means of photopatterning of enzyme-containing photosensitive membrane precursors. This device shows no cross-talk and a lifetime for both the glucose and the lactate sensors of more than 2 weeks when continuously operated in undiluted bovine serum. Linear response ranges of up to 40 mM for glucose and 25 mM for L-lactate, in combination with 95% response times of 0.98 with respect to laboratory techniques. Subcutaneous measurements of glucose levels in pigs were close to the corresponding blood levels obtained without in vivo calibration.
- Published
- 1996