1. HDAC3 is essential for DNA replication in hematopoietic progenitor cells
- Author
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Summers, Alyssa R., Fischer, Melissa A., Stengel, Kristy R., Zhao, Yue, Kaiser, Jonathan F., Wells, Christina E., Hunt, Aubrey, Bhaskara, Srividya, Luzwick, Jessica W., Sampathi, Shilpa, Chen, Xi, Thompson, Mary Ann, Cortez, David, and Hiebert, Scott W.
- Subjects
Gene expression -- Physiological aspects -- Analysis -- Health aspects ,DNA replication -- Physiological aspects -- Analysis ,Leukemia -- Genetic aspects -- Care and treatment ,Lymphomas -- Genetic aspects -- Care and treatment ,Genetic engineering -- Health aspects ,Health care industry - Abstract
Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional [...]
- Published
- 2013
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