177 results on '"P. Castellan"'
Search Results
2. Rotterdam mobile phone appincluding MRI data for the prediction of prostate cancer: A multicenter external validation
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L. Cindolo, C. De Nunzio, R. Lombardo, R. Bertolo, P. Bove, A. Minervini, F. Sessa, G. Muto, M. Vittori, G. Bozzini, P. Castellan, F. Mugavero, M. Falsaperla, L. Schips, A. Celia, M. Bada, A. Porreca, A. Pastore, Y. Al Salhi, M. Giampaoli, G. Novella, R. Rizzetto, N. Trabacchin, G. Mantica, A. Antonelli, G. Pini, S. Remmers, and A. Tubaro
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
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3. Perspective multi-reader comparison between biparametric and multiparametric MRI for muscle-invasiveness assessment in bladder cancer: can we expect a contrast-free Vesical Imaging Reporting and Data System (VI-RADS)?
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A.Delli Pizzi, M. Marchioni, D. Mastrodicasa, G. Primiceri, F. Di Fabio, B. Seccia, E. Mincuzzi, M. Romanelli, B. Sessa, R. Cianci, P. Castellan, R. Castellucci, A. Colasante, L. Schips, R. Basilico, and M. Caulo
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
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4. Rotterdam mobile phone app including MRI data for the prediction of prostate cancer: A multicenter external validation
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C. De Nunzio, R. Lombardo, L. Cindolo, R. Bertolo, A. Minervini, G. Muto, P. Bove, M. Vittori, G. Bozzini, P. Castellan, F. Mugavero, M. Falsaperla, L. Schips, A. Celia, M. Bada, A. Porreca, A. Pastore, Y. Al Salhi, M. Giampaoli, G. Novella, G. Mantica, G. Pini, R. Sebastiaan, A. Antonelli, and A. Tubaro
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Diseases of the genitourinary system. Urology ,RC870-923 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2020
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5. Cloacal exstrophy variant in a female: A case report
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Shelley Warner, Luciana Lerendegui, Monica D. Chow, David Lasko, Miguel Castellan, and Felipe Pedroso
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Case report ,Cloacal exstrophy ,Omphalocele-exstrophy-imperforate anus-spinal defect ,Anorectal malformation ,Congenital genitourinary defects ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Introduction: Cloacal exstrophy is a rare birth defect that affects both the genitourinary and gastrointestinal tract, with an estimated incidence between 1:200,000 and 1:400,000 live births. The exact mechanism that leads to this defect is still unknown. Our purpose is to report a case of omphalocele-exstrophy-imperforate anus-spinal defect (OEIS) complex with a rare variant to add to the literature. Case presentation: A 28-year-old female with no known medical history had a monochorionic diamniotic twin pregnancy. At 20 weeks of gestation a prenatal ultrasound demonstrated multiple fetal anomalies on twin B, including omphalocele, absent right kidney, non-visualization of bladder, and single umbilical artery. She had a scheduled Cesarean section at 34 weeks and 5 days of gestation. Twin B had a large omphalocele with an intact sac. Below the omphalocele, there was a cecal plate with a prolapsed ileum and a second small orifice corresponding to the hindgut. Two hemivaginas and hemiclitorises were appreciated inferior to the cecal plate but superior to a bladder plate bridge joining both halves. Each of the hemivaginas was connected to a hemiuterus with its own fallopian tube and ovary. The bladder was on both sides of the cecal plate and connected in the midline adopting a crescent shape with the concave side facing cephalad. Genetic testing confirmed an XX karyotype. On day-of-life 5 the patient underwent omphalocele repair and closure of the abdominal wall, tubularization of the cecal plate, and an end colostomy. Additionally, the hemivaginas and hemiclitorises were relocated to an orthotopic position and the bladder plates were joined together and used to cover part of the abdominal wall defect. She was discharged on day of life 42 with a weight of 2.72 kg. She continues to follow up outpatient. Her second stage procedure is still pending. Conclusion: The position of the genital tract superior to the bladder exstrophy observed in this case has not been described before and is not fully explained by the current theories on the development of OEIS.
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- 2024
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6. Modification of the existing maximum residue levels for cycloxydim in various crops
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,Cycloxydim ,MRL ,pesticide ,various crops ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue levels (MRLs) for the active substance cycloxydim in pome fruits, apricots/peaches, peas (with pods), maize/corn, sugar beet roots and milk (sheep). The data submitted in support of the request were found to be sufficient to derive MRL proposals for pome fruits, peas (with pods), maize/corn and sugar beet roots while for apricots, peaches and sheep milk no changes to the existing MRLs were considered necessary. Adequate analytical methods for enforcement are available to control the residues of cycloxydim according to the current enforcement residue definition in the commodities under consideration. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the uses of cycloxydim according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2024
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7. Review of the existing maximum residue levels for difenoconazole according to Article 12 of Regulation (EC) No 396/2005
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,difenoconazole ,fungicide ,MRL review ,regulation (EC) No 396/2005 ,triazole derivative metabolites ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance difenoconazole. To assess the occurrence of difenoconazole residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Council Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the European authorisations reported by Member States and the UK (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived, and a consumer risk assessment was carried out. Some information required by the regulatory framework was missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, some MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered.
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- 2024
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8. Systemic inflammatory markers and volume of enhancing tissue on post-contrast T1w MRI images in differentiating true tumor progression from pseudoprogression in high-grade glioma
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Camilla Satragno, Irene Schiavetti, Eugenia Cella, Federica Picichè, Laura Falcitano, Martina Resaz, Monica Truffelli, Stefano Caneva, Pietro Mattioli, Daniela Esposito, Alessio Ginulla, Claudio Scaffidi, Pietro Fiaschi, Alessandro D’Andrea, Andrea Bianconi, Gianluigi Zona, Laura Barletta, Luca Roccatagliata, Lucio Castellan, Silvia Morbelli, Matteo Bauckneht, Isabella Donegani, Paolo Nozza, Dario Arnaldi, Giulia Vidano, Flavio Gianelli, Salvina Barra, Elisa Bennicelli, and Liliana Belgioia
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High-grade glioma ,Pseudoprogression ,Systemic Immune-Inflammation Index ,Neutrophil-Lymphocyte Ratio ,Post-contrast T1-weighted volume ,Volumetric analysis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: High-grade glioma (HGG) patients post-radiotherapy often face challenges distinguishing true tumor progression (TTP) from pseudoprogression (PsP). This study evaluates the effectiveness of systemic inflammatory markers and volume of enhancing tissue on post-contrast T1 weighted (T1WCE) MRI images for this differentiation within the first six months after treatment. Material and Methods: We conducted a retrospective analysis on a cohort of HGG patients from 2015 to 2021, categorized per WHO 2016 and 2021 criteria. We analyzed treatment responses using modified RANO criteria and conducted volumetry on T1WCE and T2W/FLAIR images.Blood parameters assessed included neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). We employed Chi-square, Fisher’s exact test, and Mann-Whitney U test for statistical analyses, using log-transformed predictors due to multicollinearity. A Cox regression analysis assessed the impact of PsP- and TTP-related factors on overall survival (OS). Results: The cohort consisted of 39 patients, where 16 exhibited PsP and 23 showed TTP. Univariate analysis revealed significantly higher NLR and SII in the TTP group [NLR: 4.1 vs 7.3, p = 0.002; SII 546.5 vs 890.5p = 0.009]. T1WCE volume distinctly differentiated PsP from TTP [2.2 vs 11.7, p
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- 2024
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9. Modification of the existing maximum residue level for methoxyfenozide in aubergines
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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aubergines/eggplants ,consumer risk assessment ,methoxyfenozide ,MRL ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the Federal Public Service (FPS) Health, Food chain Safety and Environment submitted a request on behalf of Belgium (evaluating Member State, EMS) to modify the existing maximum residue level (MRL) for the active substance methoxyfenozide in aubergines/eggplants. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for aubergines/eggplants. Adequate analytical methods for enforcement are available to control the residues of methoxyfenozide in the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, the EFSA concluded that the short‐term and long‐term intake of residues resulting from the indoor use of methoxyfenozide according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2024
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10. Evaluation of confirmatory data following the Article 12 MRL review for quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop and modification of the existing maximum residue levels for quizalofop‐P‐tefuryl
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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confirmatory data ,MRL review ,pesticide ,propaquizafop ,quizalofop‐P‐ethyl ,quizalofop‐P‐tefuryl ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Arysta Life Science Great Britain Limited submitted a request to the competent national authority in Croatia to evaluate the confirmatory data that were identified for quizalofop‐P‐tefuryl in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. Since Article 12 data gaps were also set for the two other quizalofop‐P variants sharing the same residue definitions for risk assessment and monitoring, EFSA included in the present assessment all quizalofop‐P variants: quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop. Moreover, in the application submitted to Croatia, the applicant also included a request to modify the existing MRLs for quizalofop‐P‐tefuryl in grapes, sunflower seeds and soyabeans in accordance with Article 6 of Regulation (EC) No 396/2005. To address the data gaps, new data on hydrolysis efficiency of quizalofop‐P‐tefuryl, quizalofop acid, quizalofop‐pentanoic acid and quizalofop‐P‐glycerate in different matrices of animal origin in accordance with the guidance document SANTE/2020/12830 Rev.1 were submitted, along with a validated analytical method for animal commodities. EFSA concluded that the data gap on validation of the efficiency of the extraction and hydrolysis included in the enforcement method of residues in livestock animal commodities was only fully addressed for muscle, poultry liver and eggs. Regarding plant commodities, the remaining data gaps were not addressed. EFSA also considered data gaps for quizalofop‐p‐ethyl in caraway as sufficiently addressed in the context of a previous MRL application. In general, the new information provided required a revision of the existing MRLs for several commodities of plant and animal origin. Further risk management considerations are required. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of quizalofop‐P‐tefuryl according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2024
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11. Updated reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Andrea Mioč, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
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benzimidazole substances ,carbendazim ,consumer risk assessment ,MRL ,Regulation (EC) No 396/2005 ,thiophanate‐methyl ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received from the European Commission in 2020 a mandate to provide its reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl. Specifically, EFSA was asked to assess whether thiophanate‐methyl or carbendazim has clastogenic potential and, in case clastogenic potential can be excluded, to derive toxicological reference values necessary for consumer risk assessment and assessment of maximum residue levels (MRLs). Although these active substances are no longer authorised within the European Union, MRLs were established by the Codex Alimentarius Commission (codex maximum residue limits; CXLs), and import tolerances are in place. Based on the assessment of the available data, toxicological reference values and MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was found to be missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment was considered indicative only and all MRL proposals derived by EFSA still require further consideration by risk managers. In October 2022, to ensure that MRLs derived by EFSA in its assessment of 2021 are safe for consumers also in view of endocrine‐disrupting properties, EFSA was requested to carry out a follow‐up assessment taking into account the scientific criteria for identifying endocrine disruptors (ED). Based on the outcome of the assessment, the experts agreed that the reference values are also covering the concern related to the identified hazards indicative of endocrine disruption for thiophanate‐methyl. No further considerations on the impact of the ED assessment on the current reference values were needed for carbendazim since the ED criteria are not met for this substance. Therefore, the risk assessment and the MRL recommendations derived in 2021 are confirmed.
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- 2024
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12. Evaluation of confirmatory data following the Article 12 MRL review for napropamide
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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napropamide ,confirmatory data ,pesticide ,MRL review ,risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant UPL Europe Ltd submitted a request to the competent national authority in Slovenia to evaluate the confirmatory data that were identified for napropamide in the framework of the maximum residue levels (MRLs) review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gaps, a new storage stability study on grapes (high acid content commodity) was submitted while a metabolism study in fruit crops following foliar treatment, residue trials on fresh herbs and edible flowers and an analytical method for matrices difficult to analyse were not submitted. Therefore, only the data gap for storage stability was satisfactorily addressed. The new information provided required a revision of the tentative MRLs for commodities where confirmatory data were indicated. An update of the consumer risk assessment for napropamide was performed considering the new data submitted and it did not indicate any consumer intake concerns in relation to the chronic exposure.
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- 2023
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13. Modification of the existing maximum residue levels and setting of import tolerances for flupyradifurone and DFA in various crops and animal commodities
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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flupyradifurone ,difluoroacetic acid (DFA) ,various crops ,animal commodities ,pesticide ,MRL ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer CropScience SA‐NV submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue levels (MRLs) and to set import tolerances for the active substance flupyradifurone and its metabolite difluoroacetic acid (DFA) in various plant and animal commodities. The data submitted in support of the requests were found sufficient to derive MRL proposals for flupyradifurone and/or DFA in the crops under consideration. The calculated EU livestock dietary burden indicated that for several animal matrices the EU MRLs for flupyradifurone and/or DFA would need to be modified. Adequate analytical methods for enforcement are available to control the residues of both compounds in the plant and animal commodities under consideration, and in honey. Based on the risk assessment results, EFSA concluded that the proposed and authorised uses of flupyradifurone on various crops and subsequent residues of flupyradifurone and DFA in plant and animal commodities will not result in a consumer exposure exceeding the toxicological reference values and therefore is unlikely to pose a risk to consumers' health.
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- 2023
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14. Targeted review of maximum residue levels (MRLs) for fenarimol
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Ileana Miron, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,toxicological evaluation ,residue definitions ,MRL setting ,fenarimol ,non‐approved active substance ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to review the existing maximum residue levels (MRLs) for the non‐approved active substance fenarimol in view of the possible lowering of the MRLs. EFSA investigated the origin of the current EU MRLs. For existing EU MRLs that reflect previously authorised uses in the EU, or that are based on obsolete Codex maximum residue limits, or import tolerances that are not required any longer, EFSA proposed the lowering to the limit of quantification. EFSA performed a chronic and acute dietary risk assessment for the revised list of MRLs to allow risk managers to take the appropriate decisions. For some commodities, further risk management discussions are required to decide which of the risk management options proposed by EFSA should be implemented in the EU MRL legislation.
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- 2023
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15. Targeted review of maximum residue levels (MRLs) for endosulfan
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Ileana Miron, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,toxicological evaluation ,residue definitions ,MRL setting ,endosulfan ,non‐approved active substance ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to review the existing maximum residue levels (MRLs) for the non‐approved active substance endosulfan in view of the possible lowering of the MRLs. EFSA investigated the origin of the current EU MRLs. For existing EU MRLs that reflect previously authorised uses in the EU, or that are based on obsolete Codex maximum residue limits, or import tolerances that are not required any longer, EFSA proposed the lowering to the limit of quantification or to an alternative MRL. EFSA performed an indicative chronic and acute dietary risk assessment for the revised list of MRLs to allow risk managers to take the appropriate decisions. For all commodities, further risk management discussions are required to decide which of the risk management options proposed by EFSA should be implemented in the EU MRL legislation.
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- 2023
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16. Modification of the existing maximum residue levels for triclopyr in oranges, lemons and mandarins
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
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triclopyr ,oranges ,lemons ,mandarins ,pesticide ,MRL ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Agriphar SA submitted a request to the competent national authority in Ireland to modify the existing maximum residue levels (MRLs) for the active substance triclopyr in oranges, lemons and mandarins. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for these commodities. Adequate analytical methods for enforcement are available to control the residues of triclopyr in the plant matrices under consideration at the validated LOQ of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of triclopyr according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2022
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17. Modification of the existing maximum residue levels for acetamiprid in honey and various oilseed crops
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
- Subjects
acetamiprid ,honey ,various oilseed crops ,pesticide ,MRL ,consumer risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Nufarm Europe Gmbh submitted a request to the competent national authority in Austria to modify the existing maximum residue levels (MRLs) for the active substance acetamiprid in honey, linseeds, poppy seeds, mustard seeds and gold of pleasure seeds. The data submitted in support of the request were found to be sufficient to derive MRL proposals for linseeds, poppy seeds, mustard seeds and gold of pleasure seeds. For honey, however, data gaps were identified by EFSA and were not fully addressed by the justification provided by the applicant. Considering the remaining uncertainties, risk managers are given the option to either accept the justification provided and the related uncertainties or to merge the provided data with a data set from a previous application to derive an MRL proposal. Adequate analytical methods for enforcement are available to control the residues of acetamiprid in plant matrices and in honey at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of acetamiprid according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2022
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18. Modification of the existing maximum residue levels for copper compounds in other small fruits and berries
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
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copper compounds ,copper hydroxide ,other small fruits and berries ,pesticide ,MRL ,consumer risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Spiess‐Urania Chemicals GmbH submitted a request to the competent national authority in Austria to modify the existing maximum residue levels (MRLs) for the active substance copper compounds in the whole group of other small fruits and berries. The data submitted in support of the request were found to be sufficient to derive MRL proposals for the whole subgroup of other small fruits and berries. Adequate analytical methods for enforcement of mineral copper independently from its chemical form are available for matrices under consideration at the validated limit of quantification (LOQ) of 5 mg/kg. Based on indicative risk assessment results, EFSA concluded that the long‐term intake of copper residues resulting from the intended and existing uses, natural background levels and monitoring levels might present a risk to consumer health. Although residues in other small fruits and berries are minor contributors to the overall consumer exposure, a risk management decision has to be taken on whether it is appropriate to increase the existing MRLs for these crops, given that a potential consumer intake concern could not be excluded.
- Published
- 2022
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19. Evaluation of confirmatory data following the Article 12 MRL review for thiabendazole
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
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thiabendazole ,benzimidazole ,confirmatory data ,pesticide ,MRL review ,risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Spain to evaluate the confirmatory data that were identified for in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gaps, a new storage stability study, new residues trials and a validated analytical enforcement method for the determination of the relevant residues in animal products were submitted. The data gaps were considered satisfactorily addressed for the plant commodities. The new information provided required a revision of the existing MRL for avocados. As regards the commodities of animal origin, the data gaps were only partially addressed and therefore further risk management considerations are required regarding the revision of the existing MRLs which were derived from Codex MRLs. The risk assessment performed for thiabendazole was also updated. No risk was identified.
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- 2022
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20. Targeted review of maximum residues levels (MRLs) for indoxacarb
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
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indoxacarb ,MRLs ,Regulation (EC) No 396/2005 ,consumer risk assessment ,toxicological reference values ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received a mandate from the European Commission to perform a targeted review of the maximum residue levels (MRLs) for indoxacarb based on Codex maximum residue limits (CXLs) or on import tolerances which might still be maintained after the expire of the approval of the active substance. EFSA screened the existing MRLs based on CXLs or on import tolerances considering the new toxicological reference values established during the peer review process for the renewal of the approval of indoxacarb and identified the MRLs for which an acute risk could not be excluded and several MRLs that are unlikely to pose a risk for consumers. Fall‐back MRLs could not be proposed for the commodities exceeding the new toxicological reference values as no further data were provided during the call for data. Therefore, risk managers may consider maintaining only the MRLs identified during the screening as safe for consumers. However, for some of the proposed MRLs, further consideration by risk managers is needed due to the uncertainties identified.
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- 2022
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21. Modification of the existing maximum residue level for pyridate in chives
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verania
- Subjects
pyridate ,chives ,pesticide ,MRL ,consumer risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the Federal Public Service (FPS) Health, Food chain Safety and Environment submitted a request on behalf of Belgium (evaluating Member State, EMS) to modify the existing maximum residue level (MRL) for the active substance pyridate in chives. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for chives. Adequate analytical methods for enforcement are available to control the residues of pyridate on the commodity under consideration at the validated limit of quantification (LOQ) of 0.05 mg/kg pyridate equivalent. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of pyridate according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2022
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22. Selective renal artery clamp during robot assisted partial nephrectomy: The use of indocyanine green
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Michele Marchioni, Roberto Castellucci, Igino Andrea Magli, Susanna Lunardini, Martina Monti, Giulia Primiceri, Pietro Castellan, Francesco Berardinelli, and Luigi Schips
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Small renal masses ,Nephron sparing surgery ,Indocyanine green ,Kidney cancer ,Surgery ,RD1-811 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: We aim to illustrate in a step-by-step manner the use of indocyanine green during selective clamp robot-assisted partial nephrectomy (RAPN). Patient and surgical procedure: A 52-year-old female referred to our Institution with a history of an asymptomatic, accidental renal mass at the lower pole of the right kidney. The diameter of the renal mass was 3 cm at preoperative imaging, with a PADUA score of 7. We performed right transperitoneal RAPN with selective ischemia. Indocyanine green was used to control ischemic area. After tumor enucleo-resection a medullary and cortex suture was performed. At the end of the procedure a hemostatic agent was applied. Results: Intraoperative blood-loss was 100 ml, with an ischemia time of 14 min. Postoperative Hb was 11.3 g/dL and creatinine 0.7 mg/dL. On the third postoperative day the drain was removed and in the same day the patient was discharged. No postoperative complications or recurrences were found during the follow-up. Conclusion: Intraprocedural ICG administration represents a reliable method to provide enhanced insight into kidney vascularization and could represent a safe and useful tool in cases when vascular anatomy is challenging.
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- 2022
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23. Human influence on the 2021 British Columbia floods
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Nathan P. Gillett, Alex J. Cannon, Elizaveta Malinina, Markus Schnorbus, Faron Anslow, Qiaohong Sun, Megan Kirchmeier-Young, Francis Zwiers, Christian Seiler, Xuebin Zhang, Greg Flato, Hui Wan, Guilong Li, and Armel Castellan
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Event attribution ,Atmospheric river ,Extreme precipitation ,Streamflow ,British Columbia ,Flooding ,Meteorology. Climatology ,QC851-999 - Abstract
A strong atmospheric river made landfall in southwestern British Columbia, Canada on November 14th, 2021, bringing two days of intense precipitation to the region. The resulting floods and landslides led to the loss of at least five lives, cut Vancouver off entirely from the rest of Canada by road and rail, and made this the costliest natural disaster in the province's history. Here we show that when characterised in terms of storm-averaged water vapour transport, the variable typically used to characterise the intensity of atmospheric rivers, westerly atmospheric river events of this magnitude are approximately one in ten year events in the current climate of this region, and that such events have been made at least 60% more likely by the effects of human-induced climate change. Characterised in terms of the associated two-day precipitation, the event is substantially more extreme, approximately a one in fifty to one in a hundred year event, and the probability of events at least this large has been increased by a best estimate of 45% by human-induced climate change. The effects of this precipitation on streamflow were exacerbated by already wet conditions preceding the event, and by rising temperatures during the event that led to significant snowmelt, which led to streamflow maxima exceeding estimated one in a hundred year events in several basins in the region. Based on a large ensemble of simulations with a hydrological model which integrates the effects of multiple climatic drivers, we find that the probability of such extreme streamflow events in October to December has been increased by human-induced climate change by a best estimate of 120–330%. Together these results demonstrate the substantial human influence on this compound extreme event, and help motivate efforts to increase resiliency in the face of more frequent events of this kind in the future.
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- 2022
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24. Modification of the existing maximum residue levels for prosulfocarb in herbs and edible flowers
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
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prosulfocarb ,herbs and edible flowers ,herbicide ,MRL ,consumer risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Portugal to modify the existing maximum residue levels (MRLs) for the active substance prosulfocarb in herbs and edible flowers. The data submitted in support of the request were found to be sufficient to derive MRL proposals for the group of herbs and edible flowers. Adequate analytical methods for enforcement are available to control the residues of prosulfocarb in the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of prosulfocarb according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2022
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25. Setting of an import tolerance for oxathiapiprolin in blueberries
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Irene Castellan, Lucien Ferreira, German Giner, Luna Greco, Samira Jarrah, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Tobin Robinson, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, and Alessia Verani
- Subjects
Oxathiapiprolin ,blueberries ,highbush ,import tolerance ,pesticide ,MRL ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant DuPont submitted a request to the competent national authority in Ireland to set an import tolerance for the active substance oxathiapiprolin in blueberries in support of an authorised use in the United States. The data submitted in support of the request were found to be sufficient to derive a maximum residue level (MRL) proposal for highbush blueberries by noting that lowbush blueberries (Vaccinium angustifolium) are excluded from the authorised use in the United States. Adequate analytical methods for enforcement are available to control the residues of oxathiapiprolin in plant matrices at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the long‐term intake of residues resulting from the use of oxathiapiprolin according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2022
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26. Inverted Nutcracker Syndrome: A Case of Persistent Hematuria and Pain in the Presence of a Left-Sided Inferior Vena Cava
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Obi Ekwenna, Michael A. Gorin, Miguel Castellan, Victor Casillas, and Gaetano Ciancio
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Technology ,Medicine ,Science - Abstract
Nutcracker syndrome is described as the symptomatic compression of left renal vein between the aorta and the superior mesenteric artery, resulting in outflow congestion of the left kidney. We present the case of a 51-year-old male with a left-sided inferior vena cava, resulting in compression of the right renal vein by the superior mesenteric artery. Secondary to this anatomic anomaly, the patient experienced a many-year history of flank pain and intermittent gross hematuria. We have termed this unusual anatomic finding and its associated symptoms as the “inverted nutcracker syndrome”, and describe its successful management with nephrectomy and autotransplantation.
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- 2011
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27. Límites a la creación voluntaria de patrimonios de afectación para la salvaguarda de bienes
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Alvaro Gamio and Santiago Castellan
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Bienes ,Derecho civil ,Derecho privado ,Fideicomiso ,Sociedades comerciales ,Law in general. Comparative and uniform law. Jurisprudence ,K1-7720 - Published
- 2013
28. Effect of Dentin Biomodification Using Naturally Derived Collagen Cross-Linkers: One-Year Bond Strength Study
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Carina S. Castellan, Ana K. Bedran-Russo, Alberto Antunes, and Patricia N. R. Pereira
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Dentistry ,RK1-715 - Abstract
Purpose. This study investigated the long-term resin-dentin bond strength of dentin biomodified by proanthocyanidin-rich (PA) agents. Materials and Methods. Forty molars had their coronal dentin exposed, etched, and treated for 10 minutes with 6.5% grape seed extract (GSE), 6.5% cocoa seed extract ethanol-water (CSE-ET), 6.5% cocoa seed extract acetone-water (CSE-AC), and distilled water (CO). Samples were restored either with One-Step Plus (OS) or Adper Single-Bond Plus (SB). Bond strength test was performed immediately or after 3, 6, and 12 months. Results. Higher μTBS were observed for GSE immediately (SB- 62.9 MPa; OS- 51.9 MPa) when compared to CSE-ET (SB- 56.95 MPa; OS- 60.28 MPa), CSE-AC (SB- 49.97 MPa; OS- 54.44 MPa), and CO (SB- 52.0 MPa; OS- 44.0 MPa) (P
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- 2013
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29. Simultaneous retrieval of aerosol and ocean properties from PACE HARP2 with uncertainty assessment using cascading neural network radiative transfer models
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M. Gao, B. A. Franz, P.-W. Zhai, K. Knobelspiesse, A. M. Sayer, X. Xu, J. V. Martins, B. Cairns, P. Castellanos, G. Fu, N. Hannadige, O. Hasekamp, Y. Hu, A. Ibrahim, F. Patt, A. Puthukkudy, and P. J. Werdell
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Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
The University of Maryland, Baltimore County (UMBC) Hyper-Angular Rainbow Polarimeter (HARP2) will be on board NASA's Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission, scheduled for launch in January 2024. In this study we systematically evaluate the retrievability and uncertainty of aerosol and ocean parameters from HARP2 multi-angle polarimeter (MAP) measurements. To reduce the computational demand of MAP-based retrievals and maximize data processing throughput, we developed improved neural network (NN) forward models for spaceborne HARP2 measurements over a coupled atmosphere and ocean system within the FastMAPOL retrieval algorithm. To this end, a cascading retrieval scheme is implemented in FastMAPOL, which leverages a series of NN models of varying size, speed, and accuracy to optimize performance. Two sets of NN models are used for reflectance and polarization, respectively. A full day of global synthetic HARP2 data was generated and used to test various retrieval parameters including aerosol microphysical and optical properties, aerosol layer height, ocean surface wind speed, and ocean chlorophyll a concentration. To assess retrieval quality, pixel-wise retrieval uncertainties were derived from error propagation and evaluated against the difference between the retrieval parameters and truth based on a Monte Carlo method. We found that the fine-mode aerosol properties can be retrieved well from the HARP2 data, though the coarse-mode aerosol properties are more uncertain. Larger uncertainties are associated with a reduced number of available viewing angles, which typically occur near the scan edge of the HARP2 instrument. Results of the performance assessment demonstrate that the algorithm is a viable approach for operational application to HARP2 data after the PACE launch.
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- 2023
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30. On the differences in the vertical distribution of modeled aerosol optical depth over the southeastern Atlantic
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I. Chang, L. Gao, C. J. Flynn, Y. Shinozuka, S. J. Doherty, M. S. Diamond, K. M. Longo, G. A. Ferrada, G. R. Carmichael, P. Castellanos, A. M. da Silva, P. E. Saide, C. Howes, Z. Xue, M. Mallet, R. Govindaraju, Q. Wang, Y. Cheng, Y. Feng, S. P. Burton, R. A. Ferrare, S. E. LeBlanc, M. S. Kacenelenbogen, K. Pistone, M. Segal-Rozenhaimer, K. G. Meyer, J.-M. Ryoo, L. Pfister, A. A. Adebiyi, R. Wood, P. Zuidema, S. A. Christopher, and J. Redemann
- Subjects
Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The southeastern Atlantic is home to an expansive smoke aerosol plume overlying a large cloud deck for approximately a third of the year. The aerosol plume is mainly attributed to the extensive biomass burning activities that occur in southern Africa. Current Earth system models (ESMs) reveal significant differences in their estimates of regional aerosol radiative effects over this region. Such large differences partially stem from uncertainties in the vertical distribution of aerosols in the troposphere. These uncertainties translate into different aerosol optical depths (AODs) in the planetary boundary layer (PBL) and the free troposphere (FT). This study examines differences of AOD fraction in the FT and AOD differences among ESMs (WRF-CAM5, WRF-FINN, GEOS-Chem, EAM-E3SM, ALADIN, GEOS-FP, and MERRA-2) and aircraft-based measurements from the NASA ObseRvations of Aerosols above CLouds and their intEractionS (ORACLES) field campaign. Models frequently define the PBL as the well-mixed surface-based layer, but this definition misses the upper parts of decoupled PBLs, in which most low-level clouds occur. To account for the presence of decoupled boundary layers in the models, the height of maximum vertical gradient of specific humidity profiles from each model is used to define PBL heights. Results indicate that the monthly mean contribution of AOD in the FT to the total-column AOD ranges from 44 % to 74 % in September 2016 and from 54 % to 71 % in August 2017 within the region bounded by 25∘ S–0∘ N–S and 15∘ W–15∘ E (excluding land) among the ESMs. ALADIN and GEOS-Chem show similar aerosol plume patterns to a derived above-cloud aerosol product from the Moderate Resolution Imaging Spectroradiometer (MODIS) during September 2016, but none of the models show a similar above-cloud plume pattern to MODIS in August 2017. Using the second-generation High Spectral Resolution Lidar (HSRL-2) to derive an aircraft-based constraint on the AOD and the fractional AOD, we found that WRF-CAM5 produces 40 % less AOD than those from the HSRL-2 measurements, but it performs well at separating AOD fraction between the FT and the PBL. AOD fractions in the FT for GEOS-Chem and EAM-E3SM are, respectively, 10 % and 15 % lower than the AOD fractions from the HSRL-2. Their similar mean AODs reflect a cancellation of high and low AOD biases. Compared with aircraft-based observations, GEOS-FP, MERRA-2, and ALADIN produce 24 %–36 % less AOD and tend to misplace more aerosols in the PBL. The models generally underestimate AODs for measured AODs that are above 0.8, indicating their limitations at reproducing high AODs. The differences in the absolute AOD, FT AOD, and the vertical apportioning of AOD in different models highlight the need to continue improving the accuracy of modeled AOD distributions. These differences affect the sign and magnitude of the net aerosol radiative forcing, especially when aerosols are in contact with clouds.
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- 2023
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31. Airborne observations during KORUS-AQ show that aerosol optical depths are more spatially self-consistent than aerosol intensive properties
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S. E. LeBlanc, M. Segal-Rozenhaimer, J. Redemann, C. Flynn, R. R. Johnson, S. E. Dunagan, R. Dahlgren, J. Kim, M. Choi, A. da Silva, P. Castellanos, Q. Tan, L. Ziemba, K. Lee Thornhill, and M. Kacenelenbogen
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Aerosol particles can be emitted, transported, removed, or transformed, leading to aerosol variability at scales impacting the climate (days to years and over hundreds of kilometers) or the air quality (hours to days and from meters to hundreds of kilometers). We present the temporal and spatial scales of changes in AOD (aerosol optical depth) and aerosol size (using Ångström exponent – AE; fine-mode fraction – FMF) over Korea during the 2016 KORUS-AQ (KORea–US Air Quality) atmospheric experiment. We use measurements and retrievals of aerosol optical properties from airborne instruments for remote sensing (4STAR; Spectrometers for Sky-Scanning Sun-Tracking Atmospheric Research) and in situ (LARGE; NASA Langley Aerosol Research Group Experiment) on board the NASA DC-8 and geostationary satellites (GOCI; Geostationary Ocean Color Imager; Yonsei aerosol retrieval – YAER, version 2) as well as from reanalysis (MERRA-2; Modern-Era Retrospective Analysis for Research and Applications, version 2). Measurements from 4STAR when flying below 1000 m show an average AOD at 501 nm of 0.36 and an average AE of 1.11 with large standard deviation (0.12 and 0.15 for AOD and AE, respectively), likely due to mixing of different aerosol types (fine and coarse mode). The majority of AOD due to fine-mode aerosol is observed at altitudes lower than 2 km. Even though there are large variations, for 18 out of the 20 flight days, the column AOD measurements by 4STAR along the NASA DC-8 flight trajectories match the South Korean regional average derived from GOCI. GOCI-derived FMF, which was found to be slightly low compared to AErosol RObotic NETwork (AERONET) sites (Choi et al., 2018), is lower than 4STAR's observations during KORUS-AQ. Understanding the variability of aerosols helps reduce uncertainties in the aerosol direct radiative effect by quantifying the errors due to interpolating between sparse aerosol observation sites or modeled pixels, potentially reducing uncertainties in the upcoming observational capabilities. We observed that, contrary to the prevalent understanding, AE and FMF are more spatially variable than AOD during KORUS-AQ, even when accounting for potential sampling biases by using Monte Carlo resampling. Averaging between measurements and models for the entire KORUS-AQ period, the reduction in correlation by 15 % is 65.0 km for AOD and shorter at 22.7 km for AE. While there are observational and model differences, the predominant factor influencing spatial–temporal homogeneity is the meteorological period. High spatiotemporal variability occurs during the dynamic period (25–31 May), and low spatiotemporal variability occurs during the blocking pattern (1–7 June). While AOD and FMF / AE are interrelated, the spatial variability and relative variability of these parameters in this study indicate that microphysical processes vary at scales shorter than aerosol concentration processes at which microphysical processes such as aerosol particle formation, growth, and coagulation mostly impact the dominant aerosol size (characterized by, e.g., FMF / AE) and to some degree AOD. In addition to impacting aerosol size, aerosol concentration processes such as aerosol emission, transport, and removal mostly impact the AOD.
- Published
- 2022
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32. A Bayesian parametric approach to the retrieval of the atmospheric number size distribution from lidar data
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A. Sorrentino, A. Sannino, N. Spinelli, M. Piana, A. Boselli, V. Tontodonato, P. Castellano, and X. Wang
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Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
We consider the problem of reconstructing the number size distribution (or particle size distribution) in the atmosphere from lidar measurements of the extinction and backscattering coefficients. We assume that the number size distribution can be modeled as a superposition of log-normal distributions, each one defined by three parameters: mode, width and height. We use a Bayesian model and a Monte Carlo algorithm to estimate these parameters. We test the developed method on synthetic data generated by distributions containing one or two modes and perturbed by Gaussian noise as well as on three datasets obtained from AERONET. We show that the proposed algorithm provides good results when the right number of modes is selected. In general, an overestimate of the number of modes provides better results than an underestimate. In all cases, the PM1, PM2.5 and PM10 concentrations are reconstructed with tolerable deviations.
- Published
- 2022
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33. Explicit and consistent aerosol correction for visible wavelength satellite cloud and nitrogen dioxide retrievals based on optical properties from a global aerosol analysis
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A. Vasilkov, N. Krotkov, E.-S. Yang, L. Lamsal, J. Joiner, P. Castellanos, Z. Fasnacht, and R. Spurr
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Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
We discuss an explicit and consistent aerosol correction for cloud and NO2 retrievals that are based on the mixed Lambertian-equivalent reflectivity (MLER) concept. We apply the approach to data from the Ozone Monitoring Instrument (OMI) for a case study over northeastern China. The cloud algorithm reports an effective cloud pressure, also known as cloud optical centroid pressure (OCP), from oxygen dimer (O2−O2) absorption at 477 nm after determining an effective cloud fraction (ECF) at 466 nm. The retrieved cloud products are then used as inputs to the standard OMI NO2 algorithm. A geometry-dependent Lambertian-equivalent reflectivity (GLER), which is a proxy of surface bidirectional reflectance, is used for the ground reflectivity in our implementation of the MLER approach. The current standard OMI cloud and NO2 algorithms implicitly account for aerosols by treating them as nonabsorbing particulate scatters within the cloud retrieval. To explicitly account for aerosol effects, we use a model of aerosol optical properties from a global aerosol assimilation system and radiative transfer computations. This approach allows us to account for aerosols within the OMI cloud and NO2 algorithms with relatively small changes. We compare the OMI cloud and NO2 retrievals with implicit and explicit aerosol corrections over our study area.
- Published
- 2021
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34. Variability in lidar-derived particle properties over West Africa due to changes in absorption: towards an understanding
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I. Veselovskii, Q. Hu, P. Goloub, T. Podvin, M. Korenskiy, Y. Derimian, M. Legrand, and P. Castellanos
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Measurements performed in western Africa (Senegal) during the SHADOW field campaign are analyzed to show that spectral dependence of the imaginary part of the complex refractive index (CRI) of dust can be revealed by lidar-measured particle parameters. Observations in April 2015 provide good opportunity for such study, because, due to high optical depth of the dust, exceeding 0.5, the extinction coefficient could be derived from lidar measurements with high accuracy and the contribution of other aerosol types, such as biomass burning, was negligible. For instance, in the second half of April 2015, AERONET observations demonstrated a temporal decrease in the imaginary part of the CRI at 440 nm from approximately 0.0045 to 0.0025. This decrease is in line with a change in the relationship between the lidar ratios (the extinction-to-backscattering ratio) at 355 and 532 nm (S355 and S532). For instance in the first half of April, S355∕S532 is as high as 1.5 and the backscatter Ångström exponent, Aβ, is as low as −0.75, while after 15 April S355/S532=1.0 and Aβ is close to zero. The aerosol depolarization ratio δ532 for the whole of April exceeded 30 % in the height range considered, implying that no other aerosol, except dust, occurred. The performed modeling confirmed that the observed S355∕S532 and Aβ values match the spectrally dependent imaginary part of the refractive index as can be expected for mineral dust containing iron oxides. The second phase of the SHADOW campaign was focused on evaluation of the lidar ratio of smoke and estimates of its dependence on relative humidity (RH). For five studied smoke episodes the lidar ratio increases from 44±5 to 66±7 sr at 532 nm and from 62±6 to 80±8 sr at 355 nm, when RH varied from 25 % to 85 %. Performed numerical simulations demonstrate that observed ratio S355∕S532, exceeding 1.0 in the smoke plumes, can indicate an increase in the imaginary part of the smoke particles in the ultraviolet (UV) range.
- Published
- 2020
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35. Ultrafast Vibrational Relaxation Dynamics in XUV-Excited Polycyclic Aromatic Hydrocarbon Molecules
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A. Boyer, M. Hervé, V. Despré, P. Castellanos Nash, V. Loriot, A. Marciniak, A. G. G. M. Tielens, A. I. Kuleff, and F. Lépine
- Subjects
Physics ,QC1-999 - Abstract
Unraveling ultrafast molecular processes initiated by energetic radiation provides direct information on the chemical evolution under extreme conditions. A prominent example is interstellar media where complex molecules such as polycyclic aromatic hydrocarbons (PAHs) are excited by energetic photons. Until recently, ultrafast dynamics following such excitations remained largely unexplored due to the lack of relevant technologies. Here, we use time-resolved mass spectrometry combining ultrashort femtosecond XUV and IR pulses, to investigate the dynamics induced by high-energy photon excitation in PAHs. We demonstrate that excited cations relax through a progressive loss of vibrational selectivity, created at the early-stage dynamics, and which represents the first steps of a complete intramolecular vibrational energy redistribution. This process is in competition with the recently revealed correlation-band dynamics. These results might have direct consequences for the development of XUV molecular physics and other fields such as astrochemistry.
- Published
- 2021
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36. The Tropical Atlantic Observing System
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G. R. Foltz, P. Brandt, I. Richter, B. Rodríguez-Fonseca, F. Hernandez, M. Dengler, R. R. Rodrigues, J. O. Schmidt, L. Yu, N. Lefevre, L. Cotrim Da Cunha, M. J. McPhaden, M. Araujo, J. Karstensen, J. Hahn, M. Martín-Rey, C. M. Patricola, P. Poli, P. Zuidema, R. Hummels, R. C. Perez, V. Hatje, J. F. Lübbecke, I. Polo, R. Lumpkin, B. Bourlès, F. E. Asuquo, P. Lehodey, A. Conchon, P. Chang, P. Dandin, C. Schmid, A. Sutton, H. Giordani, Y. Xue, S. Illig, T. Losada, S. A. Grodsky, F. Gasparin, T. Lee, E. Mohino, P. Nobre, R. Wanninkhof, N. Keenlyside, V. Garcon, E. Sánchez-Gómez, H. C. Nnamchi, M. Drévillon, A. Storto, E. Remy, A. Lazar, S. Speich, M. Goes, T. Dorrington, W. E. Johns, J. N. Moum, C. Robinson, C. Perruche, R. B. de Souza, A. T. Gaye, J. López-Parages, P.-A. Monerie, P. Castellanos, N. U. Benson, M. N. Hounkonnou, J. Trotte Duhá, R. Laxenaire, and N. Reul
- Subjects
tropical Atlantic Ocean ,observing system ,weather ,climate ,hurricanes ,biogeochemistry ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The tropical Atlantic is home to multiple coupled climate variations covering a wide range of timescales and impacting societally relevant phenomena such as continental rainfall, Atlantic hurricane activity, oceanic biological productivity, and atmospheric circulation in the equatorial Pacific. The tropical Atlantic also connects the southern and northern branches of the Atlantic meridional overturning circulation and receives freshwater input from some of the world’s largest rivers. To address these diverse, unique, and interconnected research challenges, a rich network of ocean observations has developed, building on the backbone of the Prediction and Research Moored Array in the Tropical Atlantic (PIRATA). This network has evolved naturally over time and out of necessity in order to address the most important outstanding scientific questions and to improve predictions of tropical Atlantic severe weather and global climate variability and change. The tropical Atlantic observing system is motivated by goals to understand and better predict phenomena such as tropical Atlantic interannual to decadal variability and climate change; multidecadal variability and its links to the meridional overturning circulation; air-sea fluxes of CO2 and their implications for the fate of anthropogenic CO2; the Amazon River plume and its interactions with biogeochemistry, vertical mixing, and hurricanes; the highly productive eastern boundary and equatorial upwelling systems; and oceanic oxygen minimum zones, their impacts on biogeochemical cycles and marine ecosystems, and their feedbacks to climate. Past success of the tropical Atlantic observing system is the result of an international commitment to sustained observations and scientific cooperation, a willingness to evolve with changing research and monitoring needs, and a desire to share data openly with the scientific community and operational centers. The observing system must continue to evolve in order to meet an expanding set of research priorities and operational challenges. This paper discusses the tropical Atlantic observing system, including emerging scientific questions that demand sustained ocean observations, the potential for further integration of the observing system, and the requirements for sustaining and enhancing the tropical Atlantic observing system.
- Published
- 2019
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37. OMI tropospheric NO2 air mass factors over South America: effects of biomass burning aerosols
- Author
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P. Castellanos, K. F. Boersma, O. Torres, and J. F. de Haan
- Subjects
Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
Biomass burning is an important and uncertain source of aerosols and NOx (NO + NO2) to the atmosphere. Satellite observations of tropospheric NO2 are essential for characterizing this emissions source, but inaccuracies in the retrieval of NO2 tropospheric columns due to the radiative effects of aerosols, especially light-absorbing carbonaceous aerosols, are not well understood. It has been shown that the O2–O2 effective cloud fraction and pressure retrieval is sensitive to aerosol optical and physical properties, including aerosol optical depth (AOD). Aerosols implicitly influence the tropospheric air mass factor (AMF) calculations used in the NO2 retrieval through the effective cloud parameters used in the independent pixel approximation. In this work, we explicitly account for the effects of biomass burning aerosols in the Ozone Monitoring Instrument (OMI) tropospheric NO2 AMF calculation for cloud-free scenes. We do so by including collocated aerosol extinction vertical profile observations from the CALIOP instrument, and aerosol optical depth (AOD) and single scattering albedo (SSA) retrieved by the OMI near-UV aerosol algorithm (OMAERUV) in the DISAMAR radiative transfer model. Tropospheric AMFs calculated with DISAMAR were benchmarked against AMFs reported in the Dutch OMI NO2 (DOMINO) retrieval; the mean and standard deviation of the difference was 0.6 ± 8 %. Averaged over three successive South American biomass burning seasons (2006–2008), the spatial correlation in the 500 nm AOD retrieved by OMI and the 532 nm AOD retrieved by CALIOP was 0.6, and 68 % of the daily OMAERUV AOD observations were within 30 % of the CALIOP observations. Overall, tropospheric AMFs calculated with observed aerosol parameters were on average 10 % higher than AMFs calculated with effective cloud parameters. For effective cloud radiance fractions less than 30 %, or effective cloud pressures greater than 800 hPa, the difference between tropospheric AMFs based on implicit and explicit aerosol parameters is on average 6 and 3 %, respectively, which was the case for the majority of the pixels considered in our study; 70 % had cloud radiance fraction below 30 %, and 50 % had effective cloud pressure greater than 800 hPa. Pixels with effective cloud radiance fraction greater than 30 % or effective cloud pressure less than 800 hPa corresponded with stronger shielding in the implicit aerosol correction approach because the assumption of an opaque effective cloud underestimates the altitude-resolved AMF; tropospheric AMFs were on average 30–50 % larger when aerosol parameters were included, and for individual pixels tropospheric AMFs can differ by more than a factor of 2. The observation-based approach to correcting tropospheric AMF calculations for aerosol effects presented in this paper depicts a promising strategy for a globally consistent aerosol correction scheme for clear-sky pixels.
- Published
- 2015
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38. Satellite observations indicate substantial spatiotemporal variability in biomass burning NOx emission factors for South America
- Author
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P. Castellanos, K. F. Boersma, and G. R. van der Werf
- Subjects
Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Biomass burning is an important contributor to global total emissions of NOx (NO+NO2). Generally bottom-up fire emissions models calculate NOx emissions by multiplying fuel consumption estimates with static biome-specific emission factors, defined in units of grams of NO per kilogram of dry matter consumed. Emission factors are a significant source of uncertainty in bottom-up fire emissions modeling because relatively few observations are available to characterize the large spatial and temporal variability of burning conditions. In this paper we use NO2 tropospheric column observations from the Ozone Monitoring Instrument (OMI) from the year 2005 over South America to calculate monthly NOx emission factors for four fire types: deforestation, savanna/grassland, woodland, and agricultural waste burning. In general, the spatial patterns in NOx emission factors calculated in this work are consistent with emission factors derived from in situ measurements from the region but are more variable than published biome-specific global average emission factors widely used in bottom-up fire emissions inventories such as the Global Fire Emissions Database (GFED). Satellite-based NOx emission factors also indicate substantial temporal variability in burning conditions. Overall, we found that deforestation fires have the lowest NOx emission factors, on average 30% lower than the emission factors used in GFED v3. Agricultural fire NOx emission factors were the highest, on average a factor of 1.8 higher than GFED v3 values. For savanna, woodland, and deforestation fires, early dry season NOx emission factors were a factor of ~1.5–2 higher than late dry season emission factors. A minimum in the NOx emission factor seasonal cycle for deforestation fires occurred in August, the time period of severe drought in South America in 2005, supporting the hypothesis that prolonged dry spells may lead to an increase in the contribution of smoldering combustion from large-diameter fuels, offsetting the higher combustion efficiency of dryer fine fuels. We evaluated the OMI-derived NOx emission factors with SCIAMACHY NO2 tropospheric column observations and found improved model performance in regions dominated by fire emissions.
- Published
- 2014
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39. Endovascular thrombectomy versus intravenous thrombolysis for primary distal, medium vessel occlusion in acute ischemic stroke
- Author
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Salsano Giancarlo, Salsano Antonio, Del Sette Bruno, D’Alonzo Alessio, Sassos Davide, Alexandre Andrea, Pedicelli Alessandro, Di Iorio Riccardo, Colò Francesca, and Castellan Lucio
- Subjects
dmvo ,endovascular therapy ,ivt ,acute ischemic stroke ,Medicine - Abstract
In the absence of clinical trials, the benefit of endovascular therapy (EVT) on the treatment of acute ischemic stroke (AIS) with primary distal and medium vessel occlusions (DMVO) is still not well defined. The aim of the study is to evaluate EVT with or without intravenous thrombolysis (EVT ± IVT) in primary DMVO stroke in comparison with a control cohort treated with IVT alone.
- Published
- 2024
- Full Text
- View/download PDF
40. Modification of the existing maximum residue levels in various plant commodities resulting from the use of potassium phosphonates
- Author
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,MRL ,pesticide ,phosphonic acid ,potassium phosphonates ,various crops ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants De Sangosse SAS and Tilco‐Alginure submitted two requests, respectively, to the competent national authorities in France and Germany to modify the existing maximum residue levels (MRLs) for the active substance potassium phosphonates in various plant commodities. The data submitted in support of the requests were found to be sufficient to derive MRL proposals for the commodities under assessment. For the derived MRL on baby leaf crops, further risk manager consideration is required to decide between two MRL options. Adequate analytical methods for enforcement are available to control the residues of potassium phosphonates in accordance with the residue definition ‘phosphonic acid and its salts expressed as phosphonic acid’ in the commodities under consideration. Based on the risk assessment results and assuming that the existing MRLs will be amended as proposed by EFSA in previous outputs, EFSA concluded that the long‐term intake of residues resulting from the existing uses of fosetyl and phosphonates (previously assessed in a joint MRL review) and new proposed uses of potassium phosphonates is unlikely to present a risk to consumer health. Considering the toxicological profile of the active substance, a short‐term dietary risk assessment was not required. The risk assessment shall be regarded as indicative because some MRL proposals derived by EFSA in the framework of the MRL review according to Articles 12 and 43 of Regulation (EC) No 396/2005 require further consideration by risk managers.
- Published
- 2024
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41. Review of the existing maximum residue levels for gamma‐cyhalothrin according to Article 12 of Regulation (EC) No 396/2005
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,gamma‐cyhalothrin ,insecticide ,MRL review ,pyrethroids ,Regulation (EC) No 396/2005 ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance gamma‐cyhalothrin. To assess the occurrence of gamma‐cyhalothrin residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU) No 188/2011, as well as the European authorisations reported by Member States (including the supporting residues data) in the framework of this review. Based on the assessment of the available data, MRL proposals were derived, and a consumer risk assessment was carried out. Although no risk to consumers was identified, some information required by the regulatory framework was missing. The residue definition for monitoring (lambda‐cyhalothrin (includes gamma‐cyhalothrin) (sum of R, S and S, R isomers)) covers both lambda‐ and gamma‐cyhalothrin. Appropriate enantioselective techniques, which are not commonly used in routine analysis, are required to differentiate gamma‐cyhalothrin residues from lambda‐cyhalothrin. According to the available data, it is expected that the MRLs currently set in Regulation (EC) No 396/2005 will cover the uses of gamma‐cyhalothrin assessed in the present review. Therefore, risk managers can consider maintaining the existing EU MRLs.
- Published
- 2024
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42. Nota conclusiva
- Author
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P. Castellani
- Subjects
Industries. Land use. Labor ,HD28-9999 - Published
- 2009
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43. Evaluation of confirmatory data following the Article 12 MRL review for myclobutanil
- Author
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
confirmatory data ,MRL review ,pesticide ,risk assessment ,TDMs ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Corteva Agriscience submitted a request to the competent national authority in Austria to evaluate the confirmatory data that were identified for myclobutanil in the framework of the MRL review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gap related to the lack of information on the triazole derivative metabolites (TDMs), new residue trials analysing for TDMs were submitted on apples, grapes, strawberries, tomatoes and melons. Following the assessment of the submitted data, EFSA concluded that Article 12 confirmatory data gaps are considered addressed for pome fruits, grapes, cucurbits with inedible peel, strawberries and tomatoes. The new information provided required the assessment of consumer exposure to TDMs, which identified no consumer intake concerns for the crops under consideration. No information was provided to address the Article 12 confirmatory data referred to in Regulation (EU) 2020/770 for blackberries, gooseberries, bananas, aubergines/eggplants, lamb's lettuces/corn salads, beans (with pods), globe artichokes, hops, sugar beet roots and products of animal origin. For these commodities, the existing EU MRL could be lowered to the enforcement limit of quantification (LOQ). For kaki/Japanese persimmon and azararoles/mediterranean medlars, the existing EU MRL is set on the basis of Codex MRL in pome fruits. The applicant did not request maintaining a Codex MRL in these commodities, but should risk managers decide otherwise, the Article 12 data gap is considered addressed for kaki/Japanese persimmon while for azaroles/Mediterranean medlars, a risk management decision might be required. No consumer intake concerns were identified.
- Published
- 2024
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44. Modification of the existing maximum residue levels for fluxapyroxad in kaki/Japanese persimmons and cultivated mushrooms
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,fluxapyroxad ,fungicide ,kaki/Japanese persimmons ,MRL ,mushrooms ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted two requests to the competent national authority in Spain and Ireland to modify the existing maximum residue levels (MRLs) for the active substance fluxapyroxad in kaki/Japanese persimmons and in cultivated fungi, respectively. The data submitted in support of the requests were found to be sufficient to derive MRL proposals for kaki/Japanese persimmons and cultivated fungi. Adequate analytical methods for enforcement are available to control the residues of fluxapyroxad on the commodities under consideration at the validated LOQ of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of fluxapyroxad, according to the reported agricultural practices, is unlikely to present a risk to consumer health. The long‐term consumer risk assessment is indicative, pending the submission of the confirmatory data requested under the MRL review.
- Published
- 2024
- Full Text
- View/download PDF
45. Whale fall chemosymbiotic communities in a southwest Australian submarine canyon fill a distributional gap
- Author
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Marco Taviani, Paolo Montagna, Andrew M. Hosie, Giorgio Castellan, Catherine Kemper, Federica Foglini, Malcom McCulloch, and Julie Trotter
- Subjects
Whale fall ,Chemosymbiotic invertebrates ,Ziphiidae ,Southwestern Australia ,Hood canyon ,Bremer marine park ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
A whale fall community of chemosymbiotic invertebrates living on cetacean bones has been identified off southwestern Australia during a Remotely Operated Vehicle (ROV) survey at bathyal depths within the Bremer Marine Park, which is part of important marine mammal areas (IMMA) of the Albany Canyon Region. Cetacean bones on the seafloor of the Hood Canyon, consisted of isolated skulls of three species of beaked whales (family Ziphiidae): Mesoplodon cf. layardii, M. grayi, and M. hectori, a few vertebrae, and lower jaws. One of the beaked whale skulls (Mesoplodon cf. layardii) was sampled and found to be intensely colonised by hundreds of specimens of a bathymodilinae mussel (“Adipicola” s.l.). Live polychaetes (Phyllochaetopterus?), skeneimorph gastropods, and amphipods (Seba, Leptamphopus) colonised the skull bone, which represent a later stage (sulfophilic) of carcass decomposition. The reducing sediment below the skull was inhabited by lucinid (Lucinoma) and vesicomyid (Calyptogena) chemosymbiotic bivalves. Additionally, the sediment thanatocoenosis comprised shells of various other chemosymbiotic bivalves, such as Acharax, thyasirids, lucinids, vesicomyids, and limpets, representing the complex ecological turnover phases through time in this whale fall chemosynthetic habitat. With one exception, all bones recovered were colonized by bathymodiolin mussels. This is the first documented case of a chemosynthetic community and associated chemosymbiotic fauna relating to beaked whales, and the first fully documented record of a whale fall community within the Australian Southern Ocean region.
- Published
- 2024
- Full Text
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46. Agronomische und phytochemische Charakterisierung von Brotklee-Landsorten
- Author
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Pramsohler, Manuel, Castellan, Alessia, Pérez, Mayra Galarza, and Çiçek, Serhat S.
- Subjects
α-keto acids ,blue fenugreek ,plant genetic resources ,trigonella caerulea ,Agriculture ,Botany ,QK1-989 - Abstract
Der Brotklee oder Schabziger Trigonella caerulea (L.) Ser. gehört zur Pflanzenfamilie der Fabaceae. Das getrocknete Kraut wird in der Alpenregion traditionell zum Würzen von Käse und Brot verwendet. Verschiedene α-Ketosäuren sind für das charakteristische Aroma verantwortlich, aber derzeit ist wenig über deren Vorkommen im getrockneten Pflanzenmaterial bekannt. Das Ziel dieser Arbeit war es, die agronomischen Eigenschaften und die Inhaltsstoffe von sieben Brotklee-Landsorten aus Südtirol (Italien) zu untersuchen. Die untersuchten Landsorten zeigten ähnliche agronomische Eigenschaften aber deutliche Unterschiede im Gehalt an α-Ketosäuren und in deren Zusammensetzung.
- Published
- 2023
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- View/download PDF
47. Agronomische und phytochemische Eigenschaften verschiedener Sorten von Zitronenmelisse (Melissa officinalis L.): Anbauversuch in unterschiedlichen Höhenlagen in Südtirol
- Author
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Castellan, Alessia, Pramsohler, Manuel, Martens, Stefan, Ruele, Angelika, and Ortler, Daniel
- Subjects
lemon balm ,variety trial ,alpine region ,essential oil ,rosmarinic acid ,Agriculture ,Botany ,QK1-989 - Abstract
Zitronenmelisse (Melissa officinalis L.) ist eine der am häufigsten angebauten Heilpflanzen und Hauptbestandteil vieler Kräutertees, da sie bemerkenswerte aromatische, krampflösende, karminative und entspannende Eigenschaften besitzt. Über die agronomischen und phytochemischen Eigenschaften von Zitronenmelissesorten in unterschiedlichen Höhenlagen gibt es einige Studien, jedoch gibt es nur wenige Untersuchungen dazu im Alpenraum. In den Jahren 2018 bis 2020 wurden sieben Sorten in zwei verschiedenen Höhenlagen (620 und 1100 m Meereshöhe) in der Provinz Bozen (Italien) getestet. Die Feldversuche wurden in randomisierten vollständigen Blöcken mit drei Wiederholungen durchgeführt. Für jede Sorte wurde der Trockenblattertrag und der Gehalt an ätherischem Öl und Rosmarinsäure bestimmt. Die Ergebnisse zeigten, dass je nach Sorte sowohl agronomische als auch qualitative Merkmale der Zitronenmelisse unterschiedlich waren. In diesem Zusammenhang konnte in ertragsreiche bzw. ertragsschwache Sorten sowie Sorten mit hohem bzw. niedrigem Gehalt an ätherischem Öl differenziert werden. Die Ergebnisse deuten darauf hin, dass auch in höheren Lagen in Berggebieten hohe Erträge und eine gute Qualität erzielt werden können.
- Published
- 2023
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48. Erhebung von Zikaden (Hemiptera: Auchenorrhyncha) in Kräuteranbauflächen Südtirols
- Author
-
Ruele, Angelika, Castellan, Alessia, Pramsohler, Manuel, Janik, Katrin, and Fischnaller, Stefanie
- Subjects
auchenorrhyncha ,leafhoppers ,medicinal and aromatic plants ,pests ,south tyrol ,Agriculture ,Botany ,QK1-989 - Abstract
Im Kräuteranbau kommen verschiedene Arten von Zikaden (Auchenorrhyncha) vor, die als Pflanzensaftsauger, vor allem an Lamiaceaen, Schäden verursachen. Da es in Südtirol noch keine Daten über die Zikadenfauna im Arznei-und Gewürzpflanzenanbau gibt, wurde vom Versuchszentrum Laimburg (Südtirol, Italien) 2020-2021 eine Erhebung der dort vorkommenden Zikadenarten durchgeführt. Über zwei Vegetationsperioden wurde mittels Streifnetz (Kescher) verschiedene Pflanzenarten beprobt: Zitronenmelisse (Melissa officinalis L.), Pfefferminze (Mentha x piperita L.), Salbei (Salvia officinalis L.), Rosmarin (Rosmarinus officinalis L.), Brennessel (Urtica dioica L.) und Origano (Origanum vulgare L.). Von 1.615 gekescherten Adulttieren konnten 1.317 auf Artniveau identifiziert und 15 Arten zugeordnet werden. Auf Zitronenmelisse wurden insgesamt zehn Arten nachgewiesen, wobei Eupteryx curtisii (Flor, 1861), Eupteryx atropunctata (Goeze, 1778) und Emelyanoviana mollicula (Boheman, 1845) zu den Hauptarten zählten. Acht Zikadenarten wurden auf Pfefferminze identifiziert, hier waren Em. mollicula und E. atropunctata und Eupteryx decemnotata (Rey, 1891) am häufigsten vertreten. E. decemnotata war auf Rosmarin von den wenigen detektierten Arten mit Abstand die häufigste. Auf Salbei wurden sechs Arten nachgewiesen, wie auch für Pfefferminze kamen vor allem Em. mollicula, E. atropunctata und E. decemnotata vor.An Origano- und Brennnesselpflanzen wurden generell nur wenig Zikaden-Individuen ermittelt. Zur genaueren Untersuchung ihres Fressverhaltens werden die Zikaden auf das Vorhandensein von pflanzlicher DNA untersucht. Die gewonnenen Erkenntnisse sollen als Grundlage für weitere Forschungsarbeit zum Thema ökologische Schädlingsbekämpfung dienen.
- Published
- 2023
- Full Text
- View/download PDF
49. Modification of the temporary maximum residue levels for mepiquat in cultivated fungi and oyster mushrooms
- Author
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,cultivated fungi ,Mepiquat chloride ,MRL ,oyster mushrooms ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted a request to the competent national authority in Finland to modify the temporary maximum residue level (MRL) to a permanent MRL for the active substance mepiquat in cultivated fungi (with a specific MRL for oyster mushrooms). The data submitted in support of the request (monitoring data from food business operators) are not sufficient to derive permanent MRL proposals. The assessment of these data, complemented by an analysis of the most recent monitoring data available from EU monitoring programmes, supports the conclusion that the existing t‐MRL for cultivated fungi is still sufficient to account for the residue uptake in cultivated mushrooms other than oyster mushrooms. It was also noted that lower t‐MRLs could be derived based on the assessment of the most recent monitoring data. A risk management decision is still needed on whether to maintain the existing t‐MRL value. Regarding oyster mushrooms, EFSA derived different options for risk managers to eventually update the values of the temporary MRLs based on the most recent monitoring data from food business operators. Adequate analytical methods for enforcement are available to control the residues of mepiquat (expressed as mepiquat chloride) in the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the cross‐contamination of untreated cultivated fungi (including oyster mushrooms) from cereal straw lawfully treated with mepiquat according to the current agricultural practices is unlikely to present a risk to consumer health.
- Published
- 2024
- Full Text
- View/download PDF
50. Evaluation of confirmatory data following the Article 12 MRL review and modification of the existing maximum residue levels for aluminium phosphide and magnesium phosphide
- Author
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
aluminium phosphide ,confirmatory data ,magnesium phosphide ,MRL review ,pesticide ,risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Detia Freyberg GmbH submitted to the competent national authority in Germany two requests to evaluate the confirmatory data that were identified for tree nuts, oilseeds, cereals and commodities of animal origin in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available and two requests in accordance with Article 6 of Regulation (EC) No 396/2005 to increase the existing MRL for the active substance aluminium phosphide in peanuts, barley, oat, rye, rice and wheat, roots of herbal infusions, cocoa beans and seed spices and for the active substance magnesium phosphide in oilseeds (except peanuts) and pistachios. The four applications were combined by EFSA under the current assessment. To address the data gaps, validation data for the method of analysis for enforcement of phosphide in high‐oil content commodities and new residue trials were submitted. The data gaps on additional residue trials supporting authorisations on oilseeds and cereal grains, on clarifications regarding the discrepancies observed in the residue trial results for pistachios, and on data confirming the negligible occurrence of phosphane and its oxidation products in livestock products were considered addressed. The data gap on independent laboratory validation (ILV) and a confirmatory method for monitoring of phosphide in high‐oil content commodities was considered not fully addressed. The information provided justified a lowering of the current tentative MRLs for the whole group of cereals (except rice and ‘others’), an increase of the current tentative MRLs for pistachios, the whole group of oilseeds, rice and ‘other’ cereals, herbal infusions from roots, cocoa beans and seed spices, and a revision of the risk assessment performed for phosphane and its phosphide salts. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of AlP and Mg3P2 according to the reported agricultural practices is unlikely to present a risk to consumer health. Further risk management considerations are required.
- Published
- 2024
- Full Text
- View/download PDF
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