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Abstract Background An increasing number of older people are experiencing homelessness and memory problems, many of whom are supported in temporary hostel accommodation. This can be a challenge for hostel staff who may not have adequate training and support but who often support those with significant memory impairment in their day-to-day work. The study aimed to investigate the training and support that hostel staff require to meet the needs of older hostel residents experiencing memory and cognitive problems, and thus enhance hostel resident quality of life and well-being, considering what additional knowledge, skills, and support hostel staff need to achieve this. Methods In this qualitative study, we conducted inductive reflexive thematic analysis of semi-structured interviews with health and social care practitioners (n = 17) and hostel staff and managers (n = 15). Participants were recruited from six homelessness hostels, one specialist care home, and National Health and Local Authority Services in England. Results We identified three main themes: (a) Emotional and psychoeducational support needs within hostel staff teams, including training on memory and cognitive problems, responsive behaviours, communication strategies, and reflective spaces for hostel staff to manage their emotional responses (b) Training and support needs to deliver a person-centred approach, including tools and support packages to enhance hostel residents’ independence, multidisciplinary meetings to evaluate hostel residents’ needs, and communication strategies tailored to hostel residents’ understanding and (c) Support to facilitate collaboration with external agencies, including training on professional language, capacity assessment, dementia case studies, improved communication skills to bring external services into hostels, and reflective practices to advocate for hostel residents with dual diagnoses. Conclusions The present study highlights how hostel staff could benefit from targeted training in emotional support, person-centred approaches for older hostel residents with memory and cognitive problems, and collaboration with external services. Overall, the current study contributes to understanding of the need for tailored training and support methods within hostels to provide higher quality support to a population that is frequently overlooked.

Abstract To assess the utility of IVIM parameters in evaluating uterine fibroid blood flow compared to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) derived blood flow. Sixteen premenopausal women with uterine fibroids were enrolled in this prospective study. Pelvic MRI scans were obtained for each subject, both with and without continuous intravenous infusion of oxytocin, known to decrease significantly uterine fibroid blood flow, to assess the changes in blood flow of uterine fibroids. IVIM and DCE analyses were conducted using separate dedicated software. The bi-exponential IVIM model was used to estimate perfusion fraction (f), pseudo-diffusion coefficient (D*), and diffusion coefficient (D). DCE blood flow values were derived via T1 perfusion deconvolution arithmetic, utilizing a first pass of an AIF curve. The correlation between the parameters were analyzed by Spearman’s rank correlation analysis due to small sample size. Means of the parameters were compared with a nonparametric Wilcoxon sign rank method for each pair. Statistically significant positive correlations were found between perfusion fraction values and DCE blood flow values with oxytocin (Spearson’s ρ = 0.78, p = 0.0004), and between fD* values and DCE blood flow values with oxytocin (Spearson’s ρ = 0.64, p = 0.0071). Significant differences in blood flow were detected across most IVIM parameters: f, D*, and fD* (p

Abstract Background The rapid evolution of healthcare necessitates a new generation of doctors with strong critical thinking, problem-solving, and adaptability skills. This systematic review explores current longitudinal assessment practices in undergraduate medical education in Saudi Arabia with particular emphasis on progress test and its utility, advantages, and disadvantages. Methods A systematic search was conducted across relevant databases to identify studies that discuss progress test in undergraduate medical education in Saudi Arabia. The studies were analyzed to evaluate their alignment with study objectives and to the demands of a changing healthcare landscape. Results The review highlights the dynamic nature of progress test (PT) as a longitudinal assessment method in undergraduate medical education in Saudi Arabia. The advantages included yearly assessments and holistic feedback to enhance learning techniques and knowledge retention. Moreover, PT serves as both a summative and formative assessment, offering personalized learning experiences tailored to individual needs and pacing. Contrasting traditional assessments, PT promotes deep learning strategies and meaning-oriented approaches, fostering holistic understanding rather than rote memorization. Additionally, PT’s continuous nature allows for early identification of knowledge gaps and facilitates ongoing improvement. Conclusion This systematic review provides a comprehensive overview of progress test as a longitudinal assessment method in undergraduate medical education. It identifies areas for improvement and informs the development of more effective assessment methods that better prepare future doctors for a future of innovation and personalized medicine.

Abstract Obesity is a modifiable risk factor for breast cancer. Yet, how obesity contributes to cancer initiation is not fully understood. The goal of this study was to determine if the body mass index (BMI) and metabolic hallmarks of obesity are related to DNA damage in normal breast tissue. In a mouse model of diet-induced obesity, weight gain was associated with elevated levels of DNA double-strand breaks in the mammary gland. We also found a positive correlation between BMI and DNA breaks in the breast epithelium of premenopausal women (but not postmenopausal women). High BMI was associated with elevated systemic and tissue-level oxidative DNA damage across the lifespan, and we propose that the breast epithelium undergoing menstruous proliferation waves is particularly prone to the generation of DNA breaks from oxidative lesions. Ancestry was an important modulator of the obesity-DNA break connection. Compared to non-Hispanic Whites, women identifying as African Americans had higher levels of DNA breaks, as well as elevated leptin and IGF-1. In 3D cultures of breast acini, both leptin and IGF-1 caused an accumulation of DNA damage. The results highlight a connection between premalignant genomic alterations in the breast epithelium and metabolic health modulated by obesity and ancestry. They call for attention on biological determinants of breast cancer risk disparities.

Background Given pregnant mothers' high frequency of vitamin D (25(OH)D) deficiency and the potential consequences for the health of the unborn child. Prenatal vitamin D administration raises maternal and baby 25(OH)D levels.Aims to assess the 25(OH)D supplementation effects on rate of clinical pregnancy and miscarriage in women with hyper androgenic polycystic ovarian disorder. Methods A prospective study was conducted on 200 patients with hyper androgenic polycystic ovarian disease, at outpatient infertility clinic, Menoufia University Hospital during from March 2021 till March 2022. The cases divided into group (A) included 100 women given a therapeutic dose of 25(OH)D supplements, while group (B) included 100 women didn't given 25(OH)D supplements. Results duration needed to reach follicle ≥18 mm was significantly higher among group B (16.74±2.57), compared with group A (13.40±2.12). While, midluteal progesterone was significantly higher among group A (19.63±2.12), compared with group B (17.74±2.36), (P

Abstract Background Globally, breast cancer ranks among the most common malignancies and has a high mortality rate. Invasive breast carcinoma of no special type (IBC-NST) presents a heterogeneous group with variable prognosis. Identifying reliable biomarkers is crucial for improving treatment strategies and predicting outcomes. This study investigates the immunohistochemical expression of parathyroid hormone-related protein (PTHrP) and ezrin in IBC-NST and their correlation with clinicopathological features and overall survival. Methods This retrospective study analyzed 160 paraffin-embedded tissue samples, including 123 IBC-NST and 37 normal breast tissues, collected from patients treated at Menoufia University Hospital during the period from January 2018 to January 2022. Immunohistochemical staining for PTHrP and ezrin was performed, and expression levels were quantified using the H score. Results PTHrP expression was significantly higher in IBC-NST than in adjacent DCIS and normal tissues (p

Abstract Background Cervical myelopathy refers to an impairment of the spinal cord. It frequently occurs due to constriction of the cervical spinal canal. Cervical spondylotic myelopathy is the primary reason for spinal cord impairment in older individuals. Ossification of the posterior longitudinal ligament (OPLL) is rare although potentially significant factor contributing to degenerative cervical myelopathy. The etiology of OPLL is inadequately understood. Materials and methods This research aims to perform a comprehensive review and meta-analysis to assess the clinical outcomes of both anterior and posterior techniques in treating cervical compressive myelopathy caused by cervical OPLL. A comparative study examining the surgical findings of anterior and posterior approaches for cervical myelopathy owing to OPLL was conducted between January 2006 and October 2021. We reviewed online databases such as PubMed, EMBASE, and the Cochrane Library. This systematic review and meta-analysis (MA) covered 12 research articles including 1070 participants. Results Showed no statistically significant variations among the anterior group and posterior group regarding preoperative modified Japanese Orthopedic Association Score (mJOA score) (P = 0.23, SMD = 0.9; heterogeneity: P = 0.85; I 2 = 18%). However, the postoperative mJOA score was significantly greater in the anterior group contrasted to the posterior group (P = 0.004, SMD = 0.67; heterogeneity: P

This paper addresses the challenge of controlling the formation of multi-agent system based only on the relative distances between agents obtained individually by local sensors mounted on each autonomous agent in the system. Based on the graph rigidity approach, the inter-agent sensing and communication topology is presented as a rigid graph, and the control model is designed for each agent as a distributed control scheme. This study shows the capability of utilizing graph rigidity in designing distance-based formation control for multi-agent system. It also shows the applicability of the approach to achieve formation control for more complex formations in both two and three-dimensional spaces. To validate the effectiveness and capability of the proposed formation control strategy, three complex formation scenarios are conducted and simulated using MATLAB. These scenarios involve both formation acquisition and maneuvering problems and consider double-integrator multi-agent systems with 5 and 12 agents. The simulation results show the effectiveness of the distance-based formation control based on the graph rigidity, by demonstrating the exponential stability of the controlled system and the convergence of the agents to the desired formation in less than 3 seconds even for a system of 12 agents. The system stability proof is provided using Lyapunov stability theorem. In addition to ensuring system stability, this study shows that the graph rigidity approach implicitly ensures inter-agent collision avoidance.This study demonstrates the effectiveness of using graph rigidity approach in designing formation control of multi-agent system based only on the relative distances between agents, which ensures system stability

Abstract Insider threats pose a significant challenge to IT security, particularly with the rise of generative AI technologies, which can create convincing fake user profiles and mimic legitimate behaviors. Traditional intrusion detection systems struggle to differentiate between real and AI-generated activities, creating vulnerabilities in detecting malicious insiders. To address this challenge, this paper introduces a novel Deep Synthesis Insider Intrusion Detection (DS-IID) model. The model employs deep feature synthesis to automatically generate detailed user profiles from event data and utilizes binary deep learning for accurate threat identification. The DS-IID model addresses three key issues: it (i) detects malicious insiders using supervised learning, (ii) evaluates the effectiveness of generative algorithms in replicating real user profiles, and (iii) distinguishes between real and synthetic abnormal user profiles. To handle imbalanced data, the model uses on-the-fly weighted random sampling. Tested on the CERT insider threat dataset, the DS-IID achieved 97% accuracy and an AUC of 0.99. Moreover, the model demonstrates strong performance in differentiating real from AI-generated (synthetic) threats, achieving over 99% accuracy on optimally generated data. While primarily evaluated on synthetic datasets, the high accuracy of the DS-IID model suggests its potential as a valuable tool for real-world cybersecurity applications.

Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.Our results proved that the MTHFR c.677C > T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G > A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies.

Abstract Background The pandemic of coronavirus disease–19 (COVID-19) has a profound influence on the health of the population. This study aimed to assess the weight changes and its relation to the dietary habits and physical activity among adult Egyptian population during the second wave of COVID-19 pandemic. Materials and methods This cross–sectional study was conducted using anonymous online questionnaire. The questionnaire was distributed across Egypt via community–based networks, social and institutional emailing lists, and professional organizations to collect data on sociodemographic, clinical history, dietary and lifestyle habits, physical activity, anthropometric measurements, and stressing factors. Results The study participants (n = 1000) had a median (interquartile range) age of 34.0 (23.0–40.0) years, with 18.7% males, 96.6% having university or postgraduate education. Among them, 69.1% reported weight gain, 21.3% no change, and 9.6% weight loss. Weight loss was predicted by following COVID-19 pandemic reports daily [adjusted odds ratio (AOR) = 0.50 (95% CI, 0.27–0.93), p = 0.03], monthly income change [AOR = 2.52 (95% CI, 1.51–4.22), p

Abstract Background Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder characterized by diverse symptoms and lesions impacting the esophagus and adjacent regions, resulting from the backward flow of stomach contents into the esophagus. Eosinophilic esophagitis (EoE) has become a significant alternative diagnosis for persons with persistent GERD symptoms. This study aims to assess the prevalence of EoE in Egyptian patients who inadequately react to GERD treatments. Methods Esophageal tissue samples were collected from all patients exhibiting persistent GERD symptoms. EoE was identified based on esophageal mucosal biopsies showing at least 15 eosinophils per high-power field (HPF) and symptoms suggestive of esophageal dysfunction, following the exclusion of other causes of eosinophilia. Results Thirty hundred patients with persistent GERD symptoms were included in this study. These patients were divided into two groups: those diagnosed with EoE (n = 12) and those without this condition (n = 288). Dysphagia (p = 0.012), occult blood in stool (p = 0.024) and H. pylori antigen (p = 0.013) were significantly in favour of patients with eosinophilic oesophagitis and these factors were predictors of eosinophilic oesophagitis (p

Abstract This research aims to develop a conceptual framework and assessment tool to assess sustainability of Multifunction Constructed Wetlands Projects (MCWP). First, by literature review to analyze the main points and identify the gaps in existing research to what concerns viewing constructed wetlands as multifunction sustainable landscape projects. To assess the performance of MCWP, urban sustainability indicators are proposed examining interconnections between environmental, economic and social aspects and their effects on each other. 12 environmental, 9 socio-cultural and 7 economic indicators are selected according to their relevance to the United Nations and National Sustainable Development Goals, the impacts of their weights according to a distributed questionnaire showed these percentages: environmental aspects 42%, Socio-cultural aspects 29% and the economic aspects 28%. Also, performance-oriented assessment tools for MCWPs were designed for wastewater treatment. The impacts of proposed indicators are then assessed using the adapted Leopold Matrix method. Hence, this study aims to establish an assessment model to evaluate the sustainability features of MCWPs, by proposing sustainability indicators to be assessed by measurement metrics and respective weights for indicators and sub-indicators.

Abstract Background Increasing demand for durable and aesthetically pleasing dental restorations, including laminates, inlays, onlays, and crowns, has led to advancements in all-ceramic systems, particularly with the development of advanced lithium disilicate materials. However, limited data on the fit accuracy and fracture resistance of these materials restricts their wider application in clinical restorative practices. Aim of the study This in vitro study aims to compare the marginal and internal fit, assess the fracture resistance, and evaluate the failure modes of crowns fabricated from advanced and conventional lithium disilicate materials. Materials and methods Thirty two (n = 32) crowns were fabricated and categorized into two groups based on the material used: Group (CT), where crowns were milled from CEREC Tessera (n = 16), and Group (EM), where crowns were milled from IPS e.max CAD (n = 16) using a CAD/CAM system. The marginal and internal fit were assessed digitally via a triple scan protocol. All samples were subjected to a fracture resistance test with a universal testing machine, followed by an analysis of failure modes under a stereomicroscope. Results In the evaluation of marginal, internal and total gaps, CEREC Tessera (CT) showed slightly better fit with lower gap values compared to e.max CAD (EM). However, an independent samples t-test indicated no statistically significant differences between the two groups (p = 0.141, p = 0.471). For fracture resistance (N), the CT group demonstrated higher values than the EM group; however, the independent samples t-test indicated no statistically significant difference (p = 0.053). Additionally, the Chi-squared test with Monte Carlo correction revealed no statistically significant differences in the modes of fracture between the two groups (p = 0.484). Conclusion Considering the limitations of this study, advanced lithium disilicate crowns demonstrated better results in terms of marginal fit, internal adaptation, and fracture resistance compared to traditional lithium disilicate crowns; however, the differences were not statistically significant. Both materials exhibited comparable fracture patterns.

In the dynamic field of cybersecurity within intelligent vehicle systems, the sophistication of threats necessitates continual advancements in security technologies. Traditional Network Intrusion Detection Systems (NIDS) often fall short in detecting emerging and sophisticated intrusion methods, primarily due to their reliance on static datasets that fail to capture the nuanced dynamics and complexity of modern network intrusions. This study presents a sophisticated simulation for NIDS tailored to intelligent vehicle environments, utilizing the extensive capabilities of Scapy—a robust network manipulation tool—to generate a highly accurate dataset of network traffic reflective of real-world scenarios. We created a diverse dataset involving 100,000 network flows, covering a wide array of benign, malicious, and anomalous traffic patterns, to thoroughly evaluate the detection capabilities of our proposed system. This dataset was analyzed using a deep learning framework employing a Convolutional Neural Network (CNN), which demonstrated outstanding performance metrics: an accuracy of 99.08%, precision of 98.96%, recall of 99.11%, and an F1 score of 99.03%. These metrics showcase the system's enhanced capability to precisely classify various network flows, emphasizing the importance of realistic synthetic data in boosting the training and accuracy of NIDS in intelligent vehicles. The results of this research are significant, marking a step forward towards more flexible and preemptive security measures for intelligent vehicles, and effectively narrowing the gap between simulation-based testing and real-world network environments.

Abstract Low Voltage Ride Through (LVRT) is considered one of the main and serious problems facing the electrical grid. It occurs due to three-phase symmetric faults and asymmetric faults such as a double line to ground fault that applies in this system. This paper applies Static Synchronous Compensators (STATCOM) to improve the LVRT capability and dynamic performance of an electrical grid linked to a Photovoltaic (PV)/Wind hybrid system through grid disturbances. A hybrid power system containing a PV station that produces 1 MW and a wind farm from type Doubly Fed Induction Generator (DFIG) that produces 9 MW is connected to STATCOM with 48 pulses at PCC bus and energized load. It compensates reactive power to improve LVRT that occurred due to fault. The applied STATCOM controller adjusts the voltage of the PCC bus during an occuring fault on the grid by compensating reactive power. STATCOM is controlled by a Proportional–Integral–Derivative (PID) and is compared with STATCOM controlled by Artificial Intelligence Control (AIC)-based on Proportional—Integral Fuzzy Logic Control (PI FLC). The Lightning Attachment Procedure Optimization Algorithm (LAPO) optimization method is used to adjust the parameters of the PI controller to reduce error signals. A simulation model of the suggested hybrid power system has been performed using Matlab/Simulink. The simulation results of STATCOM proved powerful and the effectiveness of STATCOM with PI FLC in reducing voltage dip, compensating active power of wind and PV farm, protecting DC-link voltage of PV and wind from overvoltage and oscillation that happens at three-phase fault and double line to ground fault as compared with PID STATCOM in enhancement LVRT capability, and power quality.

Abstract Background The Protozoan pathogen Eimeria is a significant issue in poultry production. Scientists are concerned with finding alternative strategies due to the spread of resistance against the commonly employed coccidiostats. This study examined how well myrrh extract (MyE) protected domesticated pigeons from an experimental Eimeria labbeana-like infection. Methods Female pigeons were divided into six groups (5 pigeons/group): Group 1: control pigeon group, Group 2: Non-infected and treated pigeon group with MyE (500 mg/kg). Group 3: Infected and non-treated pigeon group, Group 4: Infected and treated pigeon group with MyE (250 mg/kg), Group 5: Infected and treated pigeon group with MyE (500 mg/kg), Group 6: Infected and treated pigeon group with amprolium (1 g/L of H2O). Oral infection with 3 × 104 sporulated E. labbeana-like oocysts was used to inoculate groups (3–6). Three days after infection, groups (4–6) received daily treatment with MyE and amprolium for five days. Oocyst output was assessed on day 8 post-infection. After sacrificing the pigeons, the small intestine and blood were collected from each pigeon and processed for histological, biochemical, and oxidative damage examinations. Results This study looked into the overall phenolic and flavonoid contents and MyE’s antioxidant activity. According to the data, the best dose of MyE was 500 mg/kg, which significantly decreased the output of oocysts produced (2.090 × 105 ± 1.04 × 104 oocysts/g.feces). This result has been linked to a -2.51% decrease in the pigeon’s body weight gain. The morphometric characteristics of freshly unsporulated and sporulated oocysts were obtained, and pigeons treated with MyE significantly decreased size. Furthermore, there was a significant decrease in both the number and size of the developmental stages of E. labbeana-like (i.e. meronts, gamonts, and developing oocysts) in the intestinal tissue among the MyE-treated group. MyE facilitates the disruption of intestinal homeostasis caused by E. labbeana-like infection, specifically concerning carbohydrates and proteins. Concurrent with the state of total antioxidant capacity (TAC), the antioxidant activity of MyE reduced the blood plasma levels of trace elements (Fe, Cu, Cr, Zn, and Ni). Conclusion Our findings suggest that MyE could be a useful antioxidant source and a replacement for coccidiostats in preventing and treating avian coccidiosis.

In a 16-month study addressing global agricultural soil heavy metal contamination, researchers explored plant-centered solutions using Jacaranda plants. The impact of different combinations of cadmium nitrate (40, 80, and 120 mg) and lead nitrate (400, 800, and 1200 mg/kg soil) were evaluated relative to Jacaranda’s remediation capabilities. Employing a randomized complete block design with 8 applications across 3 repetitions, the study assessed growth traits and chemical characteristics. Untreated plants showed higher growth values, contrasting with reduced values in plants exposed to elevated cadmium (Cd) and lead (Pb) levels. For instance, the treatment with 120 mg Cd/kg soil + 1200 mg Pb/kg soil led to a 28% reduction in plant height, 13% in main stem diameter, 41% in branch number, and 35% in leaf area compared to the control. Despite these challenges, Jacaranda plants demonstrated resilience with a 100% survival rate. Plant organs showed increased Cd and Pb contents, with fallen leaves having lower metal content, mitigating pollution hazards. Post-planting, soil characteristics shifted, indicating Jacaranda's potential for Cd phytoextraction (BCF < 1 and, TF > 1) and Pb phytostabilization (BCF and TF < 1). The study establishes Jacaranda as a promising candidate for phytoremediation due to its resilience to elevated metal levels.

Background: The optimal therapeutic strategy for coronary intervention in edge in-stent restenosis (edge ISR) remains less well-defined. Aim: The aim of this study was to assess 12-month outcomes of re-stenting using drug-eluting stents (DESs) versus using drug-eluting balloon (DEB) for managing coronary edge ISR. Patients and Methods: One hundred and four patients with edge ISR were randomly assigned to either DES or DEB. The primary endpoint was stent failure at 12-month follow-up. Results: Significantly lower target vessel revascularization among the DEB group compared to restenting group, (7.7% vs. 23.1%, P = 0.04). Likewise, target vessel-related myocardial infarction rate was significantly lower among the DEB group than restenting (5.7% vs. 23.1%, P = 0.04). On the other hand, there were no significant differences in the rates of deaths or restenosis between the two groups. Conclusion: The DEB is superior to the DES with better both safety and efficacy.

Abstract Background The emulsion polymerization of vinyl monomers has been extensively researched, but copolymerization with crotonic acid or cinnamic acid is relatively uncommon. These acids are capable of coordinating with other metal ions. Our previous research has focused on synthesizing and characterizing copolymers of butyl acrylate (BuA)/vinyl acetate (VAc) and styrene-BuA using emulsion techniques, specifically for paint applications. The current work aimed to synthesize and characterize three binary chelating copolymers of styrene with maleic, cinnamic, and crotonic acids. In addition, the prepared chelating copolymers were treated with water and soluble salts of copper and iron for complex formation. Additionally, the characterization and electrical properties of these copolymers were investigated. Results This article reports the synthesis of three binary copolymers of styrene with cinnamic, crotonic, and maleic acids via an emulsion polymerization process using a redox initiation system of potassium persulfate/glucose in the presence of sodium dodecyl benzene sulfonate as an emulsifier. The prepared emulsions of the copolymers were precipitated and purified using Soxhlet extraction in a mixture of n-hexane and toluene. Spectroscopic measurements, including Fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (PXRD), in addition to thermal analysis methods like thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were employed to characterize the copolymers that were synthesized. The metal complexes of the chelating copolymers were prepared by treatment with soluble metal salts of Co(II), Cu(II), and Fe(III), purified, and characterized via IR, PXRD, TGA, and DSC. The semiconducting properties of the chelating polymers and their metal complexes were demonstrated through conductivity measurements taken at room temperature. The conductivity values ranged from 10−3 to 10−6 Ω−1 cm−1. Conclusion The research underscores the significance of the electrical characteristics of chelating copolymers and their metal complexes, particularly focusing on styrene-based binary chelating copolymers, in driving advancements in technology, science, and economic development.

Background: Colorectal cancer (CRC), which has a high mortality rate, is one of the most common malignancies. It is a growing public health problem that recently encompasses the younger age group. Inflammatory bowel disease (IBD), like (UC), is a risk factor for CRC. The aim of this study was to test the expression of microRNA-675 (miR-675) and long noncoding RNA H19 (H19) for their diagnostic and prognostic potential in CRC and UC. Methods and Results: This prospective cross-sectional study included 60 patients diagnosed with CRC, 60 patients with UC, and 30 healthy subjects as controls. The real-time RT-PCR technique quantified the expressions of the non-coding RNAs (ncRNAs) miR-675 and lncH19. The biochemical and radiological findings were assessed and correlated with the expression of the genetic biomarkers. H19 showed high expression in both CRC and UC groups, which is significantly different from the control group. There was a significantly enhanced expression of H19 in CRC, compared to the UC group. Increased H19 expression was detected in the caecum and ascending colonic lesions, with a significant difference from flexures and transverse colon (P=0.010), and recto-sigmoid colon (P=0.05). Although miR-675 showed downregulation in both UC and CRC groups, it revealed a higher expression in CRC when compared to the UC group. Conclusion: Based on our findings, we can conclude that H19 can be a potential noninvasive biomarker for the diagnosis of UC and early detection of CRC.

Background Child discipline practices are the methods used by parents to prevent future unwanted behavior in children. Child discipline practices involve non-violent and violent. Violent discipline is a pervasive problem across Egypt shaped by many factors and has many negative consequences. This study attempted to measure the prevalence of child discipline practices among mothers in Alexandria and their associated maternal psychosocial profile of mothers.Methods A cross-sectional study was conducted to interview a sample of 275 mothers at eight family health units and centers in Alexandria using interview format to collect personal and socio-demographic data in addition to The Arabic version of the parent form of Conflict Tactics Scales Parent-Child (CTSPC) form and The Arabic Version of Depression Anxiety Stress Scales (DASS).Results The study revealed that 25.09% of studied mothers were using nonviolent discipline practices (NVDP) only, while 74.18% were using psychological, physical, or severe physical violence with or without using NVDP.A significantly higher percentage of mothers who use NVDP are of high socioeconomic status compared to the other group (73.9% compared to 17.6%), they scored normal on the three domains of DASS compared to the other group (76.8% compared to 30.5% on depression domain, 72.5% compared to 14.7% on anxiety domain and 60.9% compared for 18.6% on stress domain).

This study investigates the impact of different fertilizers under varying irrigation systems and crop water requirements in water-scarce Sinai, Egypt. Field experiments were conducted during the agricultural winter seasons of 2021 and 2022 to study the response of wheat growth, yield, and water productivity under drip and furrow irrigation. The results showed that under drip irrigation system, pH showed no clear trend, while total dissolved solids (TDS) decreased with depth and were reduced by bio-fertilizer and the combination treatment. On the other hand, under furrow irrigation system, maintained a slightly alkaline pH with minimal fertilizer influence. TDS levels significantly varied, and the effects of fertilizers differed. Calcium carbonate content and organic matter varied with fertilizer types and depths. Increasing the crop water requirement from 80% to 100% improved plant growth and yield, with the 80% treatment demonstrating higher water productivity. Furrow irrigation resulted in higher growth and yields, while drip irrigation exhibited greater water productivity. Nano-fertilizer treatments consistently outperformed bio-fertilizer in growth, yields, and water productivity. Specific combinations showed superior performance due to interactions between factors. Suitable irrigation methods and regimes enhance water use efficiency. Higher irrigation levels enhance wheat growth and yield, requiring careful water management to avoid stress. Drip irrigation demonstrates superior water productivity. Reducing the water input to 80% of crop water requirements improves efficiency without compromising yield. Nano-fertilizers promote growth and grain retention as an alternative to soluble fertilizers. Combining nano with bio-fertilizers further enhances wheat growth, yield, and water productivity. These findings provide valuable insights for optimizing wheat production in water-scarce regions, considering irrigation methods, crop water requirements, and nitrogen fertilization sources.

Background: Staphylococcus aureus (S. aureus) represents a substantial public health concern due to its progressive development of antimicrobial resistance. Its virulence is significantly contributed to the released toxins. This study aimed to assess toxin encoding genes (sea, hla and pvl) and the prevalence of Methicillin-resistant S. aureus (MRSA) among S. aureus isolates gathered from Ain Shams University (ASU) Hospital and determine possible correlation of these genes with antibiotic resistance. Methods: A total of 94 isolates were obtained from various clinical departments and samples. The process of identifying the isolates was carried out utilizing standard procedures. Disc diffusion method was utilized for testing antimicrobial susceptibility. Conventional PCR was utilized for detection of sea, hla and pvl genes. Results: MRSA prevalence among collected isolates was 78.7%, ICU was significantly more frequent in MRSA. Vancomycin, linezolid and doxycycline were the most effective tested antibiotics. Isolates showed high prevalence of three genes: sea, hla genes 93.6%, pvl gene 86.2%. The three genes collectively detected in 79.8% of isolates. Both hla and pvl genes were significantly more frequent in MRSA. Positive hla and pvl genes isolates had significant more frequent resistance to beta lactams, erythromycin, ciprofloxacin and levofloxacin. In addition, positive pvl gene isolates had significant more frequent resistance to trimethoprim-sulfamethoxazole and gentamycin. Conclusion: This research reports high prevalence of MRSA isolates in ASU hospitals. A high resistance rate to antibiotics was observed in positive pvl, then in hla positive isolates. Presence of either gene may indicate increased rate of resistance to antimicrobials.

Abstract Background In recent years, antibiotic resistance rates have become a global concern for clinicians to combat the pathogenic bacteria associated with UTIs. The objective of this current paper is to explore the evidence-based use of natural products as an alternative strategy to reduce the recurrence rates among different UTI patient populations such as pregnant women, postmenopause women, and children. Main body Commonly used non-antimicrobial products to treat and prevent UTIs include vaginal estrogen, cranberry, probiotics, D-mannose, hyaluronic acid (HA), Chinese herbal medicine, and ascorbic acid. Literature supports the safety and effectiveness of utilizing these products in different UTI patients to a great extent. The strongest recommendation was given to the utilization of vaginal estrogen replacement therapy in postmenopausal females to prevent rUTI. Conclusion We believe our research is the first to provide evidence-based clinical practice guidelines and insight into UTI management using non-antimicrobial drugs in different populations. Our findings can guide future research on the reduction of antimicrobial misuse and preventing antimicrobial resistance. Graphical Abstract

Abstract Background Muscle wasting constitutes a frequent complication in critical illness and may be most prevalent in chronic critical illness as inpatients with prolonged ICU length of stay. Objective To evaluate the incidence and percentage of muscle wasting estimated by ultrasonography during ICU stay in patients with sepsis and receiving medications as corticosteroids, muscle relaxant, and certain antibiotics during ICU stay and hospital stay. Patients and methods We enrolled 90 patients diagnosed with sepsis who were admitted to ICU at Kasr Alainy Hospital were subdivided in to 3 groups: Group 1 consists of 30 patients receiving steroids. Group 2 consists of 30 patients receiving antibiotic causing muscle wasting in the form of aminoglycosides. Group 3 consists of 30 patients receiving neuromuscular blocking agents (muscle relaxants) for any indication in ICU. Results Our study included 90 patients, with mean age 50.44 ± 6.79 years, with male % 60%, APACHE II score 7.16 ± 3.59, SOFA score 7.16 ± 3.59, results showed there was a significant decline in QMT on both right and left sides as well as RFCSA on both right and left sides when compared with baseline starting from the 3rd day of ICU admission till the end of the study period (15th day of ICU admission) (P

Abstract Copper-nickel alloys are the preferred material for desalination facilities and condensers and heat exchangers that use saltwater as a coolant. The eco-friendly compounds especially Carob fruit extract (CFE) has emerged as excessive green corrosion inhibitor for alloys. Cu-Ni alloys are widely used in various industries due to their excellent corrosion resistance. However, their performance can be compromised in aggressive environments like seawater (which is approximately 3.5% NaCl). To evaluate the corrosion behavior of these alloys and the effectiveness of corrosion inhibitors, researchers often employ weight loss, potentiodynamic polarization, and impedance spectroscopy techniques. The results showed that CFE exhibited a good ability to decrease the CR of alloys in 3.5% NaCl solution. The inhibition efficacy (IE) was reached to 92.6% and ̴ 83.2% at 300 ppm dose of CFE for Cu-10Ni alloy and Cu-30Ni alloy, respectively. The CR increases with temperature rising, but the addition of CFE reduces the CR, and the reduction depends on the dose of the extract. Adsorption of the extract gives a good fit to Langmuir, Temkin, and Freundlich isotherms model. The free adsorption energies of CFE on Cu-10Ni and Cu-30Ni alloys were 17.61 and 15.86 kJ mol−1, respectively, suggesting that CFE was weakly held to both alloys. The presence of a protective film on the alloys surface is confirmed by using scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy and atomic force microscope (AFM). The study suggests that utilizing affordable, natural substances as green corrosion inhibitors presents a new strategy for promoting both resource efficiency and environmental sustainability.

Abstract Background Systemic sclerosis is a connective tissue disease of unknown etiology, characterized by vasculopathy, fibrosis, inflammation, and immune dysregulation that lead to widespread internal organs fibrosis, chronic ischemia, and subsequent end-stage organ failure. Our purpose was to examine the role of human epididymis protein IV as a biomarker of interstitial lung disease severity in comparison to Krebs von den Lungen-VI glycoprotein and apoprotein A2 among systemic sclerosis patients. Results There was a highly significant elevation of serum human epididymis protein IV between systemic sclerosis patients (both with and without interstitial lung disease) and the control group (p

One major difficulty facing the healthcare industry is the early and precise detection of melanoma. With its capacity to record a broad spectrum of electromagnetic wavelengths, hyperspectral imaging (HSI) is a promising technique for accurate melanoma diagnosis. However, the limited accessibility of HSI technology prevents it from being widely used. This article introduces a novel method for converting readily available red green blue (RGB) images to their hyperspectral counterparts using convolutional neural networks (CNNs). Through this conversion process, spectral information is improved, enabling a more thorough examination to detect melanoma. Principal component analysis (PCA) aids the machine learning algorithm in differentiating between melanoma and healthy moles in the classification model. Accuracy is significantly increased when spot detection and PCA are combined; Naïve Bayes achieves 76% accuracy in this way. These models are used in the developed web-based program SkinScan for real-time melanoma analysis, providing a useful and accessible solution. This work emphasizes how CNN-driven RGB-to-HSI conversion might improve melanoma detection accuracy and accessibility.

The oscillation property of third-order differential equations with non-positive neutral coefficients is discussed. New sufficient conditions are provided to guarantee that every solution of the considered equation is almost oscillatory. Both the canonical and non-canonical cases are considered. Illustrative examples are introduced to support the obtained results.

Abstract Scale deposition poses significant challenges in various industrial utilities, necessitating the development of eco-friendly scale inhibitors in line with environmental regulations. This study investigates the potential of two natural surfactants, Casein and Rhamnolipid, as innovative inhibitors for calcium carbonate (CaCO3) scale formation, offering an alternative to traditional water treatment chemicals. The anti-scaling characteristics of these two green surfactants were performed using conductivity and electrochemical impedance spectroscopy (EIS) techniques. Additionally, X-ray diffraction (XRD) and scanning electron microscopy (SEM) were utilized to analyze the morphology of CaCO3 crystals and understand the structural changes induced by surfactant interaction. The results revealed that Rhamnolipids significantly outperform Casein in suppressing scale formation, attributed to the adsorption of their multiple functional groups onto scale microcrystals. This adsorption modifies the crystal structure and inhibits further growth. Computational studies were employed to investigate the inhibition mechanism of these surfactants. The spatial and electrical configurations of optimal molecular structures are also analyzed using the Density Functional Theory (DFT) approach. Monte Carlo simulations on the CaCO3 (104) surface demonstrated that Rhamnolipids exhibit superior inhibition compared to Casein, as evidenced by their higher adsorption energy, indicating a more stable binding to the surface. Overall, this research highlights the potential of these natural surfactants as sustainable scale inhibitors, particularly in industries such as food and pharmaceuticals, thereby contributing to environmentally friendly water treatment solutions.

Abstract Moving towards a cleaner, greener, and more sustainable future, expanding electric vehicles (EVs) adoption is inevitable. However, uncontrolled charging of EVs, especially with their increased penetration among the utility grid, imposes several negative technical impacts, including grid instability and deteriorated power quality in addition to overloading conditions. Hence, smart and coordinated charging is crucial in EV electrification, where Vehicle-to-Grid (V2G) technology is gaining much interest. Owing to its inherited capability of bi-directional power flow, V2G is capable of enhancing grid stability and resilience, load balancing, and congestion alleviation, as well as supporting renewable energy sources (RESs) integration. However, as with most emerging technologies, there are still technical research gaps that need to be addressed. In addition to these technical impacts, other multidisciplinary factors must be investigated to promote EVs adoption and V2G implementation. This paper provides a detailed demonstration of the technical problems associated with EVs penetration in distribution networks along with quantifiable insights into these limitations and the corresponding mitigation schemes. In addition, it discusses V2G benefits for power systems and consumers, as well as explores their technical barriers and research directions to adequately regulate their services and encourage EV’s owners to its embracement. Moreover, other factors, including regulatory, social, economic and environmental ones that affect EV market penetration are being studied and related challenges are analyzed to draw recommendations that aid market growth.

Abstract Background The Japanese quail (Coturinx coturnix japonica) has a crucial role in the lives of humanity since the 12th century and continues to play main roles in our industry and scientific research. The advantages that the Japanese quail has, such as heavy egg production and high-quality meat with low cholesterol and fat contents, Moreover, the Japanese quail is easily managed, with high feeding conversion, low cost of investment, and high rate of returns. Salivary glands are a part of the lingual apparatus that secretes serios and mucous saliva. Whereas, the saliva secretions have different roles in the food variation, apprehension, and moisture of food bolus. The morphological and cytochemical analysis are done on 20 healthy Japanese quail embryos of 6th, 10th, 11th, and 13th days of incubation and 25 healthy quail chicks at hatching day old, 7th, 14th, 30th, and 60th days old. These samples are investigated histologically, histochemically, and scanned by electron microscopy serially. Our purpose of the study is to highlight the area of the oropharyngeal salivary glands and their role in food variation, as few studies spoke about that in Japanese quail. Results The primordia of the sublingual and mandibular salivary glands were noticed at the 6th and 10th days of the prehatching respectively as an epithelial bud. After hatching, both primordia were elongated and differentiated into secretory units. These glands were mucous polystomatic tubulo-alveolar paired glands, which were situated in the submucosa of the oropharyngeal floor (sublingual floor and paralingual grooves). The sublingual glands consisted of 3–5 lobes extended from the two Os ceratobranchial by their wide ends caudally, to beyond the median sulcus of the prefrenular part of the sublingual space rostrally. The taste buds were variable in size and position. The mandibular glands lay on the paralingual groove, which arose at the 10-day old embryo. The mandibular glands were located dorsomedial to the sublingual glands and extended longitudinally from the rostral border of the frenulum linguae to the caudal tips of the sublingual glands. The taste buds decreased in volume and number with advancing age. Conclusion Overall, salivary glands increase in their alcianophilic activity of the secretions with advancing age, which indicates low PH within the secretory end pieces.

Abstract Background To date, the burden and impact of substance use among epileptic patients were studied in a small number of studies and showed inconsistent findings, which may be attributed to the variation in age, test batteries, epilepsy subtypes, and substance use characteristics across research. The aim of the study was to determine the burden and impact of substance abuse among a sample of epileptic patients attending Alexandria University outpatient clinics. This study was conducted on 200 epileptic patients (100 male and 100 female patients). The diagnosis of epilepsy in those patients was confirmed by expert neurologists. Using the international league against epilepsy 2017 classification, they underwent a complete physical examination. EEG was done for all patients. Every patient was assessed using a semi-structured interview and a self-designed questionnaire to collect data concerning history of epilepsy, seizure type, EEG findings, as well as questions derived from the Addiction Severity Index (ASI). The Timeline between epilepsy and substance abuse, as well as the Effect of substance intake on epileptic seizures, were assessed. Results A total of 27 epileptic patients had a history of substance abuse; hence, the percentage of substance use among epileptic patients was 13.5%. Mean age in the male age group was (29.74 ± 11.52) years and (27.34 ± 9.35) years in females; mean seizure frequency per month was higher among males than females and this was statistically significant (P = 0.037*). More male (24%) than females (3%) had history of substance use and this was statistically significant (P

Abstract Patient preferences for medications strongly correlate with adherence; one area of interest is the choice between branded and generic drugs. Despite extensive research about brand-versus-generic drug preferences, few studies have explored severe-illness patients like those with coronary heart disease (CHD). We could not locate studies measuring preference weights of branded drugs in different classes within guideline-recommended regimens using discrete choice experiments (DCE). We aimed to explore the preference for branded medications used for secondary prevention of CHD events among patients receiving treatment at one of the largest Egyptian health insurance clinics. Patients with CHD were interviewed to choose between various therapy regimens containing brand-name and generic versions of aspirin, beta-blockers, statins, and renin–angiotensin–aldosterone system blockers (RAAS blockers). The study employed a DCE technique and followed the recommendations of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR). Seventy-two percent (149) of the 208 patients questioned were dissatisfied with at least one of their generic medications. The majority of unsatisfied patients displayed brand preferences across the four medicine classes, primarily due to the notion that generics may be less effective. Patients preferred the RAAS blocker brand the most (adjusted odds ratio [AOR]: 3.14; 95% confidence interval [CI] 2.83 to 3.48), followed by beta-blockers (AOR: 2.06; 95% CI 1.88 to 2.27) and statins (AOR: 1.5; 95% CI 1.50 to 1.61). The relative importance of each class from the patient’s perspective showed the highest importance with RAAS blockers (22.2%) and beta-blockers (14.1%), while statins and aspirin had minor importance (7.8% and 6.6%, respectively). In the present study, branded drugs for secondary CHD prevention were preferred over generic alternatives. This finding has two implications for clinical practice. Firstly, physicians and pharmacists need to assure patients about the quality of generics to insure patient satisfaction and adherence to medication. Secondly, health insurance providers need to confirm the effectiveness of generics through observational studies. Despite the well-proven protective effects of aspirin and statins, they had minor importance from the patient’s perspective, highlighting the need to enhance patient knowledge. DCE was demonstrated to be a useful tool for eliciting the genuine preferences of patients treated within the setting of health insurance.

Abstract Severe thermal skin burns are complicated by inflammation and apoptosis, which delays wound healing and contributes to significant morbidity. Diverse treatments demonstrate limited success in mitigating these processes to accelerate healing. Agents that alter cell behavior to improve healing would alter treatment paradigms. We repurposed 4-aminopyridine (4-AP), a drug approved by the US FDA for multiple sclerosis, to treat severe burns in mice (10-week-old C57BL/6 J male mice weighing 25 ± 3 g). We found that 4-AP, in the early stages of burn healing, significantly reduced the expression of pro-inflammatory cytokines IL1β and TNFα while increasing the expression of anti-inflammatory markers CD206, ARG-1, and IL10. We demonstrated increased intracellular calcium effects of 4-AP through Orai1-pSTAT6 signaling, where 4-AP significantly mitigated inflammatory effects by promoting M2 macrophage differentiation in in-vitro macrophages and post-skin burn tissues. 4-AP attenuated apoptosis, with decreases in apoptotic markers BAX, caspase-9, and caspase-3 and increases in anti-apoptotic markers BCL2 and BCL-XL. Furthermore, 4-AP promoted angiogenesis through increases in the expression of CD31, VEGF, and eNOS. Together, these likely contributed to accelerated burn wound closure, as demonstrated in increased keratinocyte proliferation (K14) and differentiation (K10) markers. In the later stages of burn healing, 4-AP increased TGFβ and FGF levels, which are known to mark the transformation of fibroblasts to myofibroblasts. This was further demonstrated by an increased expression of α-SMA and vimentin, as well as higher levels of collagen I and III, MMP 3, and 9 in mice treated with 4-AP. Our findings support the idea that 4-AP may have a novel, clinically relevant therapeutic use in promoting burn wound healing.

Abstract Background Obesity, and in particular abdominal obesity, is associated with an increased risk of developing a variety of chronic diseases. Obesity, aging, and menopause are each associated with differential shifts in the gut microbiome. Obesity causes chronic low-grade inflammation due to increased lipopolysaccharide (LPS) levels which is termed “metabolic endotoxemia.” We examined the association of visceral adiposity tissue (VAT) area, circulating endotoxemia markers, and the gut bacterial microbiome in a cohort of aged postmenopausal women. Methods Fifty postmenopausal women (mean age 78.8 ± 5.3 years) who had existing adipose measurements via dual x-ray absorptiometry (DXA) were selected from the extremes of VAT: n = 25 with low VAT area (45.6 ± 12.5 cm2) and n = 25 with high VAT area (177.5 ± 31.3 cm2). Dietary intake used to estimate the Healthy Eating Index (HEI) score was assessed with a food frequency questionnaire. Plasma LPS, LPS-binding protein (LBP), anti-LPS antibodies, anti-flagellin antibodies, and anti-lipoteichoic acid (LTA) antibodies were measured by ELISA. Metagenomic sequencing was performed on fecal DNA. Female C57BL/6 mice consuming a high-fat or low-fat diet were treated with 0.4 mg/kg diet-derived fecal isolated LPS modeling metabolic endotoxemia, and metabolic outcomes were measured after 6 weeks. Results Women in the high VAT group showed increased Proteobacteria abundance and a lower Firmicutes/Bacteroidetes ratio. Plasma LBP concentration was positively associated with VAT area. Plasma anti-LPS, anti-LTA, and anti-flagellin IgA antibodies were significantly correlated with adiposity measurements. Women with high VAT showed significantly elevated LPS-expressing bacteria compared to low VAT women. Gut bacterial species that showed significant associations with both adiposity and inflammation (anti-LPS IgA and LBP) were Proteobacteria (Escherichia coli, Shigella spp., and Klebsiella spp.) and Veillonella atypica. Healthy eating index (HEI) scores negatively correlated with % body fat and anti-LPS IgA antibodies levels. Preclinical murine model showed that high-fat diet-fed mice administered a low-fat diet fecal-derived LPS displayed reduced body weight, decreased % body fat, and improved glucose tolerance test parameters when compared with saline-injected or high-fat diet fecal-derived LPS-treated groups consuming a high-fat diet. Conclusions Increased VAT in postmenopausal women is associated with elevated gut Proteobacteria abundance and immunogenic metabolic endotoxemia markers. Low-fat diet-derived fecal-isolated LPS improved metabolic parameters in high-fat diet-fed mice giving mechanistic insights into potential pro-health signaling mediated by under-acylated LPS isoforms. Video Abstract

Abstract Background Pleuropulmonary Blastoma (PPB) is an extremely uncommon, highly aggressive tumor that arises from either the lungs or pleura. According to Dehner, PPB was classified into three groups: type I (cystic), type II (mixed), and type III (solid). Type I tends to occur more commonly in infants and has a more favorable prognosis compared to types II and III. This tumor is very rare in pediatric age group; hence, there is no consensus on the optimal treatment regimen for it to date. Type I tumors, which resemble congenital lung cysts, can eventually progress to more aggressive type II and type III tumors. This article aims to increase general awareness of this pathology, clinical presentation, and differential diagnosis in order to identify this rare entity early in its course. By presenting 4 such cases, we highlight that PPB can be missed early in diagnosis and it is important to be alert when putting this rare tumor in differential diagnosis of cystic lung lesions. Methods A retrospective study was conducted between 2015 and 2020 involving patients who had a definitive diagnosis of PPB with emphasis on clinical presentation, preoperative imaging studies, intra-operative findings, pathological reports, ancillary treatment, and outcomes. All patients were followed up every 6 months to monitor local recurrence and distant metastasis by undergoing physical exam and non-contrast enhanced CT of the chest. The primary outcome is to identify the mortality and morbidity (recurrence and distant metastasis) of PPB for cases admitted in our institute. Results Four children were diagnosed with PPB during the study period. Clinically, patients presented with manifestations ranging from respiratory distress, fever to obstructive shock and radiologically, 2 cases were presented with mediastinal mass and the other 2 presented with pneumothorax. Regrettably, none of the cases were diagnosed pre-operatively. One lesion proved to be type I, 2 were type II and one was type III. All cases underwent chemotherapy using the combination of vincristine, Adriamycin and cyclophosphamide (VAC regimen). Recurrence was detected in a type II case, around 2 years after operation, and the other type II case developed brain metastasis that was discovered 3 years after operation. Type I case showed no local or distant metastasis. Conclusion A prompt preoperative diagnosis and workup of cases of PPB is crucial to enable optimal intervention intraoperatively and early postoperative treatment. Though it is uncommon, PPB should be considered in the differential diagnosis of cystic lung lesions.

Abstract Objectives Zygomatic implant surgery can be difficult due to the limited intraoperative visibility of the surgical field and the complex anatomy of the zygomatic bone, which could lead to serious complications. This study aims to assess the accuracy of zygomatic implants placement using computer-guided surgical templates. Materials and methods A total of 13 zygomatic implants were placed in four participants. Double-sleeve drill guides were used with the help of computer-guided surgical templates designed with a lateral window. The accuracy was evaluated by measuring the linear deviations regarding the implants’ platforms and apices’ positions in addition to the angular deviations. Moreover, deviations of both implants from three fixed planes of space were measured. Results The mean linear deviation at platforms was 2.44 mm ± 1.57 and at the apices 2.32 mm ± 1 while the mean angular deviation was 3.6˚ ± 1.92. Differences at the entry points were 0.43 ± 1.79 mm, 0.39 ± 1.12 mm, and − 0.54 ± 2.00 mm from the mid-sagittal, horizontal, and coronal planes respectively. Differences at the exit points were − 0.75 ± 1.25 mm, -0.06 ± 1.09 mm, and 0.63 ± 1.24 mm from the same planes respectively. Within all planes, there was no statistically significant difference. Conclusion Given the limitations of this study, the use of the computer-guided surgical templates augmented by the double sleeve drill guides allowed favorable control over the tip of the long surgical drill away from vital structures during the zygomatic implant osteotomy. It also allowed control over alveolar crest osteotomy and its placement in a favorable prosthetic position. Overall, this protocol should be considered for further research and improvement to allow more predictable surgical outcomes while preventing the occurrence of complications. Before conducting this study, the protocol was reviewed and approved by the Research Ethical Committee of Faculty of Dentistry, Ain Shams University in meeting no. (105), on 15th of July 2020 with the application no.: (FDASU-RecD072029).

Abstract Background The prostaglandin E1 analog “misoprostol” is a drug that has powerful ecbolic effects and can be beneficial in the prevention and treatment of postpartum hemorrhage, which is the leading cause of maternal mortality worldwide. Objectives To assess the value of adding intrauterine misoprostol together with intravenous oxytocin injection compared with sublingual misoprostol together with intravenous oxytocin injection during elective cesarean section to reduce blood loss intraoperatively and prevent postpartum hemorrhage. Methods A total of 192 pregnant women were counseled and recruited from the labor and delivery unit at Kasr Al Aini Hospital, Cairo University, and equally randomized into two groups. Group (A) included 96 women who received intrauterine misoprostol (400 mg) + oxytocin. Group (B) included 96 women who received sublingual misoprostol (400 mg) + oxytocin. The primary outcome of our study was estimation of the amount of blood loss during and after cesarean delivery. The secondary outcomes were the incidence of PPH within the first 6 h after labor, the need for blood transfusion, the need for any supplementary ecbolic drugs, the need for additional surgical intervention for PPH, changes in hematocrit and hemoglobin in both groups after delivery, and the incidence of side effects of the study medications. Results We observed a significant discrepancy between the two groups in terms of postoperative Hb and Hct, postoperative differences (pre- and post-Hb and post-Hct) and EBL favoring the intrauterine group. However, no significant difference was observed between the groups with respect to excessive blood loss > 1000 ml in the 1st six hours, the need for supplementary ecbolics, the necessity for blood or blood prod, the need for additional surgical intervention (for PPH) or side effects. Conclusion Intrauterine misoprostol combined with oxytocin intravenous infusion is more effective than sublingual misoprostol combined with oxytocin intravenous infusion in lowering intraoperative blood loss and preventing postpartum hemorrhage in elective cesarean section. Trial registration This trial was retrospectively registered with the ClinicalTrials.gov Registry on 12-April-2024 (registration number: NCT06364098).

In this work, we present a comprehensive analysis of the spatio-temporal $ \mathrm{SEIR} $ epidemic model of fractional order. The infection dynamics in the proposed fractional order model (FOM) are described by a system of partial differential equations (PDEs) within a time-fractional order and diffusion operator in one-dimensional space, considering that the total population is split into four compartments: Susceptible, exposed, infected, and recovered individuals denoted as $ \mathrm{S} $, $ \mathrm{E} $, $ \mathrm{I} $ and $ \mathrm{R} $, respectively. Our contributions commence by establishing the existence and uniqueness of positively bounded solutions for the proposed FOM. Moreover, we determined all equilibrium points (EPs) and investigated their local stability based on the basic reproduction number (BRN) $ \mathcal{R}_{0} $, which is calculated by the next-generation matrix (NGM) method. Additionally, we demonstrated global stability using an appropriate Lyapunov function with fractional LaSalle's invariance principle (LIP). Sensitivity analysis of the FOM parameters was discussed to identify the most critical parameters by which the volume of disease propagation can be measured. The theoretical findings were corroborated by numerical simulations of solutions that are displayed in 3D and 2D graphs. Graphical simulations highlight the effect of vaccination on infection severity. Changing the fractional order $ \alpha $ in the proposed FOM has an influence on the speed of convergence to the steady state as a result of the memory effect. Furthermore, vaccination emerges as an effective strategy for disease control.

The principles of water sustainability are not exclusive to one civilization without the other this make led the research problem to emerge as a question: "What is the methodology of water sustainability in Islamic architecture and how it can be used as a guide-line for achieving water sustainability in contemporary architecture?”. To answer this question the research in its theoretical study demonstrated three points, begun with presenting the functions of water in Islamic architecture, then it explained how Islamic architecture depended on water as a design tool in the process of place making, and it ended with determining the principles and criteria of water sustainability in Islamic architecture. The research determined the methodology of achieving water sustainability in Islamic architecture. Depending on this methodology the research analyzed two case study projects: Alhambra palace in Spain and Al-Ghuri Sabil in Egypt, and then the research applied this methodology in one of contemporary housing projects in Egypt, and this led the research to emphasize its main hypothesis which state “the principles and criteria of water sustainability which preexists in Islamic architecture can be used as a guide-line for achieving water sustainability in contemporary architecture”.

Abstract In this body of work, a chemical known as 2-cyano-N-(4-morpholino benzyl dine) acetohydrazide (CMBAH) is explored for its ability to suppress the carbidic austempered ductile iron (CADI) corrosion in 1M H2SO4. Density functional theory was used in experiments and theoretical investigations to investigate the inhibiting impact. The corrosion of CADI alloys in 1M H2SO4 produced a corrosion resistance superior to that of CADI heat treatment (H.T.). As-cast carbidic ductile iron (CDI) 4 alloy with 1.5%t Cr-Nb has a corrosion rate (C.R.) of 11.69 mm/year, which drops to 5.31 mm/year at HT-275 °C and 6.13 mm/year at HT-375 °C. When describing the adsorption of inhibitors, the Langmuir adsorption isotherm is the most effective method. The findings of the Gads show that the inhibition was induced mainly by the physisorption on the surface CADI alloys. In addition to this, it was found that the results of the experiments and the hypotheses were largely harmonious with one another. The formation of protective layers on the CADI surfaces is also visible in the images captured by the SEM. In 1M H2SO4, these Schiff base inhibitors effectively prevent corrosion caused by CADI. However, the combination of inhibitors leads to a fine microstructure with ausferrite and narrow ferrite needles, promoting corrosion resistance. The CADI needles rated an upper ausferritic microstructure with wide ferrite needles.

Abstract Trifluoromethyl arenes (Ar–CF3) are amongst the commonly encountered fluorinated substructures in pharmaceutical, agrochemical, and material sciences. However, predominant methods to access Ar–CF3 possess several limitations, including harsh conditions, lack of availability of substrates, and poor regioselectivity, which combined restrict access to desirable highly functionalized Ar–CF3-containing compounds. To expand the scope of accessible Ar–CF3-based molecules, we present an orthogonal deoxyfluoroalkylation/aromatization approach that exploits readily accessible and programable cyclohexan(en)one substrates, which undergo a reliable 1,2-addition reaction with the Ruppert-Prakash reagent (TMSCF3) followed by aromatization to deliver highly functionalized Ar–CF3 compounds in a one/two-pot sequence. This general strategy enables access to highly substituted Ar–CF3-containing molecules that are difficult, expensive, and/or impossible to access by current synthetic methods.

Abstract Background Acinetobacter baumannii (A. baumannii) is a life-threatening and challenging pathogen. In addition, it accounts for numerous serious infections, particularly among immunocompromised patients. Resistance to nearly all clinically used antibiotics and their ability to spread this resistance is one of the most important concerns related to this bacterium. Objectives This study describes different molecular mechanisms of two multidrug-resistant A. baumannii isolates obtained from endotracheal aspirates collected from the neonatal intensive care unit (NICU), Ain Shams University Hospital, Egypt. Methods Following the identification of two isolates, they were examined for susceptibility to antimicrobial agents. This was followed by multilocus sequence typing as well as whole-genome sequence (WGS). Additionally, a Pathosystems Resources Integration Center (PATRIC) analysis was performed. Results Two isolates, Ab119 and Ab123, exhibited resistance to all tested antibiotics except for tigecycline and colistin. The WGS analysis of antimicrobial resistance genes (AMR) indicated that both isolates shared beta-lactam, aminoglycoside, macrolides, and sulfonamide resistance genes. Furthermore, each strain revealed different resistance genes such as blaNDM-1, blaNDM-10, OXA-64, aph (3')-VI, Tet-B in Ab119 strain and blaOXA-68, blaPER-1, blaPER-7, Tet-39 in Ab123 strain. Multiple efflux pump genes were detected. Multilocus sequence typing indicated that both isolates belong to the same sequence type (ST931), which belongs to international clone (IC3). Both isolates exhibited the presence of multiple mobile genetic elements (MGEs), but no plasmid was detected in either of them. Conclusions A low prevalence of the IC3 sequence type was identified among two A. baumannii isolates obtained from the NICU in Egypt, exhibiting a high resistance level. Healthcare workers must have knowledge regarding the prevalence of A. baumannii among different populations in order to administer suitable treatment, improve patient outcomes, and apply effective infection control practices.

Abstract Enterococci, common hospital-acquired infections in immunocompromised patients, have garnered attention in clinical microbiology. To determine the clinical relevance of enterococci as food-borne pathogens, 116 fish, 90 vegetables, and 120 human diarrheal samples were tested for E. faecalis and E. faecium pathogenicity. Conventionally, 69 of 326 (21.17%) samples were positive for Enterococcus species, 52 (15.95%) of which were molecularly classified as E. faecalis and 13 (3.99%) as E. faecium. The E. faecalis contamination percentage of fresh fish (19.70%) was higher than frozen fish (4%). Cauliflower had the highest E. faecalis percentage (16.67%) when fish and vegetable samples didn’t harbor the E. faecium atpA gene. 23.33% and 10.83% of participants’ samples were molecularly confirmed as E. faecalis and E. faecium positive, respectively. E. faecalis isolates had all virulence genes, with gels being the most common (65.38%), while cylA and asa1 genes couldn’t be detected in E. faecium isolates. E. faecalis showed the highest resistance against vancomycin and tetracycline (69.23%), whereas E. faecium extremely resisted tetracycline (76.92%) and erythromycin (69.23%) with the recognition of MDR among 44.2% of E. faecalis and 38.5% of E. faecium isolates. The great similarity of our isolates showed the clinical importance of food-borne antibiotic-resistant enterococci.

Objectives: The phytochemicals in the aerial parts of Euphorbia paralias (also known as Sea Spurge) and their anti-inflammatory and antimicrobial activities were investigated.Methods: The methanolic extract was characterized using GC-MS and HPLC techniques. The anti-inflammatory feature was estimated through a Human Red Blood Cell (HRBC) membrane stabilization technique, while the antimicrobial feature was evaluated by the disc diffusion agar technique, minimum bactericidal concentration, and minimum inhibitory concentration (MIC) via micro-broth dilution method.Results: The GC/MS results demonstrated the existence of various phytochemicals, such as n-hexadecenoic acid, cis-11-eicosenoic acid, and methyl stearate, recognized for their anti-inflammatory and antibacterial features. The similarity of the phytochemical composition with other Euphorbia species emphasizes the genus-wide similarity. The antiinflammatory activity exhibited a noteworthy inhibitory effect comparable to the reference drug indomethacin. The extract’s antimicrobial potential was tested against a range of microorganisms, demonstrating significant action against Gram-positive bacteria and Candida albicans . The quantification of total phenolics and flavonoids further supported the therapeutic potential of the extract.Conclusion: The methanolic extract from E. paralias emerges as a successful natural source of important active constituents with potential applications as anti-inflammatory and antimicrobial agents. This research provides a first step to valorize Euphorbia paralias insights as a source of worthwhile phytochemicals that have potential applications in the pharmaceutical industry.

Abstract Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting one in five women of reproductive age. Polycystic appearance of the ovaries in ultrasonography is associated with oligomenorrhea, and clinical and or biochemical hyperandrogenism. PCOS has been associated with voice alterations for many years. However, there is insufficient research on voice analysis in PCOS patients. Objectives This research aimed to examine the voice characteristics among women with PCOS. Patients and methods Our study included 25 women confirmed with PCOS and 25 control. A complete voice assessment was performed for all participants using primary demographic data, vocal symptoms, auditory perceptual evaluation of the voice, Arabic version of the Voice Handicap Index, acoustic analysis, and video laryngoscopic examination of the larynx. Results Our study revealed statistically significant differences between PCOS and control groups in phonasthenic symptoms, auditory perceptual assessment of the voice, acoustic parameters, and laryngoscopic examination. Conclusion PCOS women with hirsutism are complaining of vocal symptoms, changes in vocal characters, and deterioration of the acoustic parameters of the voice. High serum levels of androgen can cause the deepening of the voice, which is essential for the early detection of vocal symptoms in PCOS patients to prevent virilization of their voice. Trial registration NCT06085170. Registered 20 August 2023—retrospectively registered, https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://classic.clinicaltrials.gov/ct2/show/NCT06085170&ved=2ahUKEwjEyLqUq6KGAxWxRPEDHb57DIQQFnoECBQQAQ&usg=AOvVaw1xTurnA6mJEZ9PK0vQS8VL .

Abstract Background Acute coronary syndrome (ACS) is responsible for one-third of total deaths in people older than 35 years old. Number of prognostic models aims to estimate the future risk of mortality, or the combined risk of all-cause mortality or MI has been developed, such as GRACE score. Objective The aim of our study is to assess the utility of GA and CHA2DS2-VASc score in predicting outcomes in patients admitted with acute coronary syndromes. Patients and methods This study was conducted on 90 patients diagnosed with acute coronary syndrome who were admitted receiving PCI, CHA2DS2-VASc score was calculated on admission, and a serum sample for GA was withdrawn within 24 h from admission. Results Combined GA and CHA2DS2-VASc score could significantly predict MACCE with sensitivity 100%, specificity 79%, and diagnostic accuracy 80.9% and significantly predict hospital mortality with sensitivity 100%, specificity 75.3%, and diagnostic accuracy 76.7%; on the other hand, GRACE score can predict MACCE using cutoff point 112.5 with sensitivity 75% and specificity 66%. Conclusion It was concluded that GA and CHADSVASC score can significantly predict major adverse cardiovascular events, in-hospital mortality, and poor clinical outcomes.