Search

For fourth-order neutral differential equations (NDE) in the canonical case, we present new relationships between the solution and its corresponding function in two casses: $ p < 1 $ and $ p > 1 $. Through these relationships, we discover new monotonic properties for this equation of fourth order. Using the new relationships and properties, we derive some oscillation conditions for the equation under study. By using the Comparison and Ricatti technique, the positive solutions are excluded by providing some conditions. Lastly, we provide examples and review previous theorems from the literature to compare our findings.

This study builds upon Johannes Bremer’s thesis that the main theme of the Psalter is YHWH’s concern for the poor (the so-called Armentheologie or theology of the poor). I argue that the phrase ‘poor and needy’ does not occur randomly through the Psalter but at strategic junctures. Traced from its inception to conclusion, seven Psalms (35, 37, 40, 70, 74, 86, 109) utilize this phrase to create a trajectory that moves from suffering to triumph, from oppression to deliverance, from denigration to vindication. Along this plotline, the psalmist identifies himself with the poor and needy in a way that grounds a messianic horizon for the Psalter, foreshadowing its consummation in Jesus Christ, the ultimate royal sage who promises ‘blessing’ (ashre) for the ‘poor in spirit’ who inherit the heavenly kingdom alongside the Psalter’s poor petitioner (Psalm 72:8-14; Matthew 3:2; Luke 6:20). The Psalter thus provides hope in the midst of suffering, as the poor and needy praise God’s name after deliverance and thank him for his abundant steadfast love, culminating in God’s ultimate victory through their (eschatological) deliverance.

This paper investigates the oscillatory behavior of nonlinear third-order dynamic equations on time scales. Our main approach is to transform the equation from its semi-canonical form into a more tractable canonical form. This transformation simplifies the analysis of oscillation behavior and allows us to derive new oscillation criteria. These criteria guarantee that all solutions to the equation oscillate. Our results extend and improve upon existing findings in the literature, particularly for the special cases where $ \mathbb{T} = \mathbb{R} $ and $ \mathbb{T} = \mathbb{Z} $. Additionally, we provide illustrative examples to demonstrate the practical application of the developed criteria.

Abstract Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs). Gut microbiota plays a pivotal role in maintaining gut homeostasis. Inflammasome activation needs to be tightly regulated to limit aberrant activation and bystander damage to the host cells. Several types of inflammasomes, including Node-like receptor protein family (e.g., NLRP1, NLRP3, NLRP6, NLRP12, NLRC4), PYHIN family, and pyrin inflammasomes, interact with gut microbiota to maintain gut homeostasis. This review discusses the current understanding of how inflammasomes and microbiota interact, and how this interaction impacts human health. Additionally, we introduce novel biologics and antagonists, such as inhibitors of IL-1β and inflammasomes, as therapeutic strategies for treating gastrointestinal disorders when inflammasomes are dysregulated or the composition of gut microbiota changes.

This paper delves into the investigation of quasi-linear neutral differential equations in the third-order canonical case. In this study, we refine the relationship between the solution and its corresponding function, leading to improved preliminary results. These enhanced results play a crucial role in excluding the existence of positive solutions to the investigated equation. By building upon the improved preliminary results, we introduce novel criteria that shed light on the nature of these solutions. These criteria help to distinguish whether the solutions exhibit oscillatory behavior or tend toward zero. Moreover, we present oscillation criteria for all solutions. To demonstrate the relevance of our results, we present an illustrative example. This example validates the theoretical framework we have developed and offers practical insights into the behavior of solutions for quasi-linear third-order neutral differential equations.

Scholars and critics that gauge Lin-Manuel Miranda’s hit musical Hamilton in terms of its historical accuracy or inaccuracy miss the point about Miranda’s creative endeavor. Hamilton represents a highly visible example of what might be called “Founders fanfiction”; although the musical is rooted deeply in historical fact, primarily via Ron Chernow’s magisterial biography of Hamilton, nonetheless, as a narrative the production is a piece of popular wish-fulfilment. Certainly, the show elides or ignores some of his more unpalatable characteristics, such as his deep elitism and love of military display and power. The elaboration of certain aspects of one’s character over another is a practice common to the creative endeavor of fanfiction. In fanfic, writers often create idealized or otherwise fantastical versions of beloved media characters, placing them in situations unreflective of the traditionally established narrative. This practice lets fanfic creators craft their own narratives with their own sense of agency and identity and make them more meaningful. Miranda performs the same kind of narrative reshaping of Hamilton’s life to conform to a particular view of Hamilton, much as historians and authors before him have done in the creation of what is known as “Founders chic”—the stressing of American Founders’ virtues and character at the expense of historical dimensionality and reality. Furthermore, the play has itself become a source of multiple instances of fanfiction, signifying significant emotional connections in the story that reflect Miranda’s own self-identification with Hamilton.

This study aims to find out whether the Rongga language (hereinafter abbreviated as bR) is a vocal language, and the reasons why bR is said to be a vocal language. This study uses a qualitative method. Data was collected using observation methods, field linguistics, literature assisted by elicitation techniques, record keeping, and recording. Data were analyzed qualitatively and presented descriptively. Based on the results of this study it was found that bR is a vocal language. This is based on (1) segmentation the series of letters , , constitute a sound segment: labial prenasal inhibition [ᵐb], alveolar prenasal inhibition [ⁿd], and velar prenasal inhibition [ᵑg] so that the word -words in bR like are pronounced as [ᵐbalu] 'storm', [ⁿdate] 'create', and [ᵑgare] 'gali', and are not pronounced as [ǝmbalu], [ǝndate], and [ǝngare]. (2) Based on the canonical pattern of syllables and words, bR has a canonical pattern that always ends in a vowel, and, (3) every word from the Indonesian language that ends in a consonant, both in the middle and final positions of syllables and words when absorbed in bR always conforms to the canonical pattern of bR syllables and words. For example, [paɠa].'fence', [aɗa] 'custom', [gapa] 'easy'. Thus, the Rongga language is a vocalic language. Abstrak Penelitian ini bertujuan untuk mengetahui apakah bahasa Rongga (selanjutnya disingkat bR) merupakan bahasa vokalik, dan alasan bR mengapa dikatakan sebagai bahasa vokalik. Penelitian ini menggunakan metode kualitatif. Data dikumpulkan dengan menggunakan metode observasi, linguistik lapangan, kepustakaan dibantu teknik elisitasi, pencatatan, dan perekaman. Data dianalisis secara kualitatif dan disajikan secara deskriptif. Berdasarkan hasil penelitian ini ditemukan bahwa ternyata bR merupakan bahasa vokalik. Hal ini didasarkan pada (1) secara segmentasi rangkaian huruf , , merupakan sebuah segmen bunyi: hambat pranasal labial [ᵐb], hambat pranasal alveolar [ⁿd], dan hambat pranasal velar [ᵑg] sehingga kata-kata dalam bR seperti dilafalkan sebagai [ᵐbalu] ‘badai’, [ⁿdate] ‘buat’, dan [ᵑgare] ‘gali’, dan tidak dilafalkan sebagai [ǝmbalu], [ǝndate], dan [ǝnggare]. (2) Secara pola kanonik sukukata dan kata, bR mempunyai pola kanonik yang selalu berakhir dengan vokal, dan, (3) setiap kata dari bahasa Indonesia yang berakhir dengan konsonan, baik pada posisi tengah maupun akhir sukukata dan kata ketika terserap dalam bR selalu menyesuaikan diri dengan pola kanonik sukukata dan kata bR. Contohnya [paɠa].’pagar’, [aɗa] ‘adat’, [gapa] ‘gampang’. Dengan demikian, bahasa Rongga merupakan bahasa vokalik.

Abstract Introduction: cell's correct functionality and surveillance are brokered by a wide range of essential proceedings. The delicate equilibrium required between those phenomenon means that an error in the control mechanisms provoke the carcinogenesis commencement. In those metabolic pathways in charge of controlling the mechanisms are found the Wnt signaling pathways. Therefore, molecules that interact with the pathways mentioned, where secreted Frizzled - Related Protein 4 is located, will play a key role in the pathology knowledge. Method: a bibliographic research has been done in referral databases, such as Medline and Scopus. Results: sFRP4 has been identified as a negative modulator of the Wnt signaling pathways. This is due to its capacity of competing for the Wnt ligands and avoiding the commencement of the pathways. Otherwise, sFRP4 is essential for the control of the cancer beginning and development in those tissues where the protein is expressed, being mammary tissues considered into them. Conclusions: recent studies about the implications of sFRP4 in the development of several pathologies justify that the protein had garnered attention in recent years. Furthermore, it can be affirmed that sFRP4 presents an interesting potential as biomarker in the breast cancer treatment, diagnosis and prognosis, among other pathologies.

The present contribution bears an attempt to take a novel synchronic perspective on derivational morphology in Persian namely canonical derivation. Introduced by Corbett (2010) and being a sub branch of canonical typology approach, canonical derivation viewpoint looks for canonical instances of single grammatical categories which are the best, the clearest and the indisputable ones rendering spectacular typological definitions. In this paper, by analyzing (195) derivational affixes including (22) prefixes and (173) suffixes, we endeavored to discover whether derivational morphology is canonical in Persian or the derivational affixes are far from canonicity in some degrees. The data analysis revealed that (%34) of derivational affixes rejected the substitutability criterion and just one suffix rejected 2 criteria. In sum, among 975 points for the fully canonical system, Persian gained 904which portrayed (%7.29) deviation from the canon; in other words, it is (%93) canonical. This amount of canonicity illustrates that derivation system in Persian is so close to the canonicity of derivation systems worldwide.

This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.

Abstract Vine copula had a great impact on the study and analysis of dependence structures in various sciences. In multivariate analyses with dimensions of more than two variables, it is associated with computational complexities that solve vine copulas and these problems. In this study, in order to provide an approach to simulate potential evapotranspiration based on meteorological parameters in Birjand meteorological station from different family copulas including R‐vine, independent R‐vine, Gaussian, independent Gaussian, C‐vine, C‐vine independent, D‐vine and D‐vine independent were used. In this regard, vine copula simulation and conditional density were used. In pair correlation analysis of the studied variables using Kendall's tau statistic, dependence structure confirmed the studied parameters. The results showed a minimum correlation of −0.32 and a maximum of 0.77. The results of Akaike's information criteria (AIC), Bayesian information criteria (BIC) and LogLike statistics in evaluating the performance of vine copula dependency structure introduced the C‐vine copula as the superior copula for analysing the pair dependence of the studied variables. By introducing the superior dependency structure and internal copulas, the tree sequence of the pair of values under study was obtained. Pair of simulated values was performed using vine copula. Comparison of Kendall's tau values in both simulation and observation modes showed that Kendall's tau values were close to each other in both modes and were approximately similar. The simulation results of vine copula potential evapotranspiration values and precipitation, temperature and relative humidity values showed 92% efficiency. The efficiency of C‐vine copula in dependence analysis and simulation of potential evapotranspiration (PET) values is very high, which shows the ability of vine family copulas in multivariate analysis.

The analysis of the most common mechanisms of pragmatic focusing used by modern English-speaking authors in the reinterpretation of canonical, “roving” plots is proposed. Particular attention is paid to the context as one of the types of foregrounding, possessing ontological salience and realizing text-forming, expressive, evaluative, ludic functions. A comparative structural, compositional, and linguistic-stylistic analysis of eight literary texts intertextually correlated with the classic story of the Blue Beard made it possible to identify such methods of attention distribution in the modeled by A. Carter, D. Bartelmi, J. Updike, J. K. Oates, S. King, M. Atwood, W. Vernon, and F. Block as a ludic mode of formulating narratives, changing narrative perspectives, introducing “text within the text”, meta- fictional commentary. Along with focusing mechanisms, the article also pays attention to the defocusing of some traditional narrative elements, which is believed to be an integral part of the interpretation program of the literary texts under consideration. The authors of numerous versions of the story about Bluebeard, foregrounding various language “games of focus”, highlight the creative transformations of archetypal images and cross-cutting motives that reflect gender, socioeconomic, cultural changes in modern society.

Lesions to posterior temporo-parietal brain regions are associated with deficits in perception of global, hierarchical shapes, but also with impairments in the processing of objects presented under demanding viewing conditions. Evidence from neuroimaging studies and lesion patterns observed in patients with simultanagnosia and agnosia for object orientation suggest similar brain regions to be involved in perception of global shapes and processing of objects in atypical (‘non-canonical’) orientation. In a localizer experiment, we identified individual temporo-parietal brain areas involved in global shape perception and found significantly higher BOLD signals during the processing of non-canonical compared to canonical objects. In a multivariate approach, we demonstrated that posterior temporo-parietal brain areas show distinct voxel patterns for non-canonical and canonical objects and that voxel patterns of global shapes are more similar to those of objects in non-canonical compared to canonical viewing conditions. These results suggest that temporo-parietal brain areas are not only involved in global shape perception but might serve a more general mechanism of complex object perception. Our results challenge a strict attribution of object processing to the ventral visual stream by suggesting specific dorsal contributions in more demanding viewing conditions.

Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck tumor. It is a high incidence malignant tumor associated with a low survival rate and limited treatment options. Accumulating conclusions indicate that the Wnt signaling pathway plays a vital role in the pathobiological process of HNSCC. The canonical Wnt/β-catenin signaling pathway affects a variety of cellular progression, enabling tumor cells to maintain and further promote the immature stem-like phenotype, proliferate, prolong survival, and gain invasiveness. Genomic studies of head and neck tumors have shown that although β-catenin is not frequently mutated in HNSCC, its activity is not inhibited by mutations in upstream gene encoding β-catenin, NOTCH1, FAT1, and AJUBA. Genetic defects affect the components of the Wnt pathway in oral squamous cell carcinoma (OSCC) and the epigenetic mechanisms that regulate inhibitors of the Wnt pathway. This paper aims to summarize the groundbreaking discoveries and recent advances involving the Wnt signaling pathway and highlight the relevance of this pathway in head and neck squamous cell cancer, which will help provide new insights into improving the treatment of human HNSCC by interfering with the transcriptional signaling of Wnt.

This paper deals with the works of Mikhail Aleksandrovich Vrubel inspired by the oeuvre of Mikhail Yuryevich Lermontov and his view of the themes of Angel and Demon, eternal ones both in the Russian and world literature. The author records the reception of their respective works in their environment, as well as the extent to which they ft the then religious and artistic canons.

A novel compact broadband Canonical Sleeve Antenna (CSA) covering 500-3600 MHz with omni directional characteristics is presented in this paper. A new method is employed in which the radiating antenna structure is designed as combination of three different canonical structures: hemispherical, conical and cylindrical elements. To accomplish the broad bandwidth with compact size, dipole antenna is designed by using cylindrical sleeve over the hemispherical dipole with conical extensions and cylindrical attachments. Performance characteristics of CSA is simulated and compared with BiConical Antenna (BCA) and other antenna configurations and found to be best antenna configuration with compact form factor. The antenna has height of 111.43 mm and diameter of 116.66 mm. Simulation studies are carried out using CST Microwave Studio. The simulated results are validated by fabricating CSA and evaluating its performance metrics. CSA has 7.2:1 bandwidth with measured VSWR

Background/Aims: Alcohol (ethanol, EtOH) as significant contributor to traumatic injury is linked to suppressed inflammatory response, thereby influencing clinical outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed alcohol`s effects and mechanisms underlying its influence on NF-ĸB-signaling during acute inflammation in human lung epithelial cells. Methods: A549-cells were stimulated with interleukin (IL)-1β, or sera from trauma patients (TP) or healthy volunteers, with positive/negative blood alcohol concentrations (BAC), and subsequently exposed to EtOH (170 Mm, 1h). IL-6-release and neutrophil adhesion to A549 were analyzed. Specific siRNA-NIK mediated downregulation of non-canonical, and IKK-NBD-inhibition of canonical NF-ĸB signaling were performed. Nuclear levels of activated p50 and p52 NF-ĸB-subunits were detected using TransAm ELISA. Results: Both stimuli significantly induced IL-6-release (39.79±4.70 vs. 0.58±0.8 pg/ml) and neutrophil adhesion (132.30±8.80 vs. 100% control, p

In this work, we obtained new sufficient and necessary conditions for the oscillation of second-order differential equations with mixed and multiple delays under a canonical operator. Our methods could be applicable to find the sufficient and necessary conditions for any neutral differential equations. Furthermore, we proved the validity of the obtained results via particular examples. At the end of the paper, we provide the future scope of this study.

Wnt signaling plays a central regulatory role across a remarkably diverse range of functions during embryonic development, including those involved in the formation of bone and cartilage. Wnt signaling continues to play a critical role in adult osteogenic differentiation of mesenchymal stem cells. Disruptions in this highly-conserved and complex system leads to various pathological conditions, including impaired bone healing, autoimmune diseases and malignant degeneration. For reconstructive surgeons, critically sized skeletal defects represent a major challenge. These are frequently associated with significant morbidity in both the recipient and donor sites. The Wnt pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for skeletal tissue regeneration and promote bone growth, suggesting that Wnt factors could be used to promote bone healing after trauma. This review summarizes our current understanding of the essential role of the Wnt pathway in bone regeneration and repair.

The canonical discriminant analysis (CDA) was performed in order to check the hypothesis of chemical separation infraspecific taxa of Pinus nigra J.F. Arnold (ssp. nigra, var. gocensis, ssp. pallasiana, and var. banatica) in Serbia based on variability of the needle terpenes. The CDA, which maximizes variations between a priori groups, showed division of seven native P. nigra populations into three groups, which belong to three taxonomically recognized taxa (ssp. nigra, ssp. pallasiana, and var. banatica). The most important characters in discrimination were (E)-caryophyllene, α-humulene, terpinolene, germacrene D, α-pinene, and myrcene. The individuals of pallasiana group were poorer in (E)-caryophyllene and terpinolene and richer in α-humulene contrary to the individuals of nigra group. The individuals of banatica group had the highest content of α-pinene and myrcene. The obtained results were compared with recently published data on chemodiversity of P. nigra infraspecific taxa on the territory of Serbia.

Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis of multiple myeloma. Tumor microenvironment-derived cytokines and cancer-associated genetic mutations signal through the canonical as well as the non-canonical arms to activate the NF-κB system in myeloma cells. In fact, frequent engagement of both the NF-κB pathways constitutes a distinguishing characteristic of myeloma. In turn, NF-κB signaling promotes proliferation, survival and drug-resistance of myeloma cells. In this review article, we catalog NF-κB activating genetic mutations and microenvironmental cues associated with multiple myeloma. We then describe how the individual canonical and non-canonical pathways transduce signals and contribute towards NF-κB -driven gene-expressions in healthy and malignant cells. Furthermore, we discuss signaling crosstalk between concomitantly triggered NF-κB pathways, and its plausible implication for anomalous NF-κB activation and NF-κB driven pro-survival gene-expressions in multiple myeloma. Finally, we propose that mechanistic understanding of NF-κB deregulations may provide for improved therapeutic and prognostic tools in multiple myeloma.

This article tries to discover the meaning of the donkey narrative (Num 22:21–35) in the context of Num 22–24. Against common exegetical interpretation it evaluates the coherence with the following blessing narrative (Num 22:41–24:25). In order to do that, a new translation of the crucial verses calls the traditional interpretation into question. Furthermore it is necessary to include the canonical context. This approach will reveal that the donkey narrative is an essential prelude to the blessing of Balaam over Israel.

The Poisson structure of intrinsic time gravity is analysed. With the starting point comprising a unimodular three-metric with traceless momentum, a trace-induced anomaly results upon quantization. This leads to a revision of the choice of momentum variable to the (mixed index) traceless momentric. This latter choice unitarily implements the fundamental commutation relations, which now take on the form of an affine algebra with SU(3) Lie algebra amongst the momentric variables. The resulting relations unitarily implement tracelessness upon quantization. The associated Poisson brackets and Hamiltonian dynamics are studied.

This paper provides a new approach to recover relative entropy measures of contemporaneous dependence from limited information by constructing the most entropic copula (MEC) and its canonical form, namely the most entropic canonical copula (MECC). The MECC can effectively be obtained by maximizing Shannon entropy to yield a proper copula such that known dependence structures of data (e.g., measures of association) are matched to their empirical counterparts. In fact the problem of maximizing the entropy of copulas is the dual to the problem of minimizing the Kullback-Leibler cross entropy (KLCE) of joint probability densities when the marginal probability densities are fixed. Our simulation study shows that the proposed MEC estimator can potentially outperform many other copula estimators in finite samples.