Search

Bernard Suits is commonly thought to have defined games as challenges. This paper argues that Suits could not have done so without ruining his larger philosophical project. It then argues that he did not do so. Suits defined game playing in quantitative terms (i.e. being more or less efficient) not qualitative ones (e.g. difficulty, struggle). The paper concludes by exploring the consequences of this shift in perspective. [ABSTRACT FROM AUTHOR]

This research aims to gain insight on the perception that minors have of viral challenges as an entertainment format and the motivations behind their participation in this digital entertainment phenomenon. A qualitative study was performed by way of twelve focus groups with sixty-two minors aged between eleven and seventeen years from Spain. For minors, viral challenges represent a form of entertainment in an interactive context, perceived as innocuous, ephemeral content from which nothing more is required than for the user to have a good time. This appears to lead the minors interviewed to ignore the meaning and origin of the viral challenges they visualise and share, neither do they regard this to be necessary. It is also important to underline the relativisation of risk and danger in favour of spectacularisation and virality. [ABSTRACT FROM AUTHOR]

Given the rising integration of digital tools into educational practices in our century, it is important to comprehend how seasoned educators adjust to these developments. This qualitative research study explored the struggles and coping mechanisms of the seasoned secondary math teachers in incorporating technology into their lessons. Using phenomenological approach, fifteen seasoned math teachers from Digos City Schools Division were interviewed using the In-depth interview I to learn about their actual experiences. The results reveal the four main challenges: seasoned teachers' technological difficulties, technological resource constraint, resistance to change, curriculum integration. Teachers use a variety of strategies to address these issues, troubleshooting skills, innovative solutions, seeking help and collaborations, and continuous professional development. The report also lists the types of assistance that school administrators should provide, professional development and learning opportunities, sharing experience and peer collaboration, resource allocation and infrastructure support, and building healthy relationships with stakeholder. The results imply that with theories of social support, resilience, and stress and coping highlight the value of specialized support systems in assisting educators in successfully navigating the challenges of teaching mathematics using technology. [ABSTRACT FROM AUTHOR]

Objective: The present study was investigate parents' experiences of children with Epidermolysis bullosa. So, this descriptive phenomenological qualitative study was conducted on 17 parents of children with EB from five hospitals affiliated with the University of Medical Sciences, west of Iran. Data was collected through semi-structured interviews. COLAIZZI's method was also used to analyze the data. Results: Three main themes were extracted in this study: invasion of psychological crisis, alive but no living, and comprehensive support, including 10 categories. The parents of these children are the target of psychological crises that severely reduce their quality of life. In this regard, they need extensive support to improve their living conditions. Therefore, it is suggested to provide cultural and institutional contexts in which all components of the children's dignity are emphasized. [ABSTRACT FROM AUTHOR]

The manufacturing industry is entering the fourth industrial revolution, which aims to shift the manufacturing paradigm to data-driven smart manufacturing. Many barriers still limit the adoption of this new revolution, although enabling technologies such as a digital twin (DT) have the potential to overcome them. Since the appearance of the digital twin technology, this has led to a significant increase in academic publications and industrial applications. However, significant challenges facing the implementation of this technology stem from the emergent field stage, a need for more comprehensive information, and a need for clarity and consistency in definitions and concepts. This review identifies and categorizes the potential digital twin challenges and provides a novel conceptual framework that structures them and links them to the principal digital twin components, along with an example that elucidates the proposed framework's utilization. The emerging relationships unveil interesting insights into the current status and future research requirements. [ABSTRACT FROM AUTHOR]

Background: L. Australis is one of the most prevalent Leptospira strains infecting dogs, leading, in natural conditions, to severe life-threatening cases. Objective: The objective was to evaluate the onset and duration of immunity (OOI and DOI) induced by a new licensed quadrivalent antileptospiral vaccine (EURICAN® L4) including four Leptospira components (Canicola, Icterohaemorrhagiae, Grippotyphosa and Australis) against L. Australis. To this end, a severe L. Australis challenge model was developed, using a canine strain recently isolated from the field. Material and Methods: Seven- to ten-week-old puppies received two doses of the vaccine four weeks apart and were challenged with an L. Australis isolate two weeks (OOI) and 12 months (DOI) later. Mortality, clinical signs, leptospiremia, leptospiruria, renal carriage, and renal lesions were assessed after challenge. Results: The challenge induced multiple severe clinical signs in controls, leading to the death or euthanasia of 83% of puppies and 57% of adults. In controls, leptospiremia was detected in all dogs, leptospiruria in 67% of puppies and 86% of adults, kidneys tested positive for Leptospira in 83% of puppies and 71% of adults, and kidney lesions were observed in 100% of puppies and 86% of adults. In addition, thrombocytopenia associated with increased concentrations of urea, creatinine, and aspartate aminotransferase was recorded in controls displaying severe clinical signs. In both OOI and DOI studies, none of the vaccinates had clinical signs, no Leptospira was detected in blood, urine, and kidney samples, and no kidney lesions were observed in vaccinates. No significant changes in hematological and biochemical parameters in vaccinates were recorded. Conclusion: EURICAN® L4 was shown to induce quick and long-lasting protection against a severe L. Australis infectious challenge, preventing mortality, clinical signs, infection, bacterial excretion, renal lesions, and renal carriage. [ABSTRACT FROM AUTHOR]

Next-generation identity verification using biometric features is nearly foolproof with the right classifier. However, selecting the correct classifier poses a key challenge, particularly in the recognition of biometric patterns. High-potential projects may face delays due to a lack of the right recognition mechanism or the malfunction of the selected classifier. This could also result from not choosing the appropriate classifier that aligns with the project's patterns. This study aims to evaluate various classifiers with potential in biometric research and the capabilities of different machine learning algorithms. Several classifiers were experimentally evaluated in combination with dynamic algorithms. The ultimate objective was to identify a standard classifier suitable for general biometric pattern recognition. Using well-known biometric pattern datasets, multivariate algorithms, such as Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA), were applied. These methods were combined with different classifiers, including SVM-L, MLP, KNN, etc. After analyzing the results obtained, the combination of LDA with MLP outperformed other approaches in terms of accuracy. [ABSTRACT FROM AUTHOR]

Research has shown that curiosity plays a crucial role in human performance and well-being. Based on multi-dimensional models of curiosity, we examined potential underlying mechanisms for this relationship. Extending prior research, we expected state and trait variants of curiosity to predict more challenge and less threat appraisals for novel tasks (i.e., joyous exploration dimension), stronger dissatisfaction when denied opportunities to do something interesting (i.e., deprivation sensitivity dimension), and persist longer under stress states (i.e., stress tolerance). We asked 123 participants to prepare and deliver a speech titled "Why are you a good friend?" After preparation, participants were informed that they were randomly selected not to perform the task. Throughout the experiment, we recorded heart rate reactivity as a physiological indicator of task engagement. We found that individuals curious about the upcoming task felt more challenged, less threatened, and presented longer physiological engagement than less curious individuals. Curious individuals expressed more disappointment about the missed opportunity to deliver the speech. In summary, this study revealed theoretically derived mechanisms that partially account for associations between curiosity and positive life outcomes while also indicating adverse effects. [ABSTRACT FROM AUTHOR]

Background: Challenge‐based learning (CBL) is a pedagogical approach increasingly adopted in engineering education. Despite its growing practice, there is little consensus in the literature about how CBL is implemented in engineering curricula and what experiences teachers and students have in relation to it. Purpose: To address this gap, the following research questions guided the study: How is CBL currently implemented in engineering education? What difficulties and lessons learned are associated with the implementation of CBL? Methods: We systematically reviewed the empirical literature published between 2010 and 2021. Forty‐eight empirical studies describing CBL implementation were analyzed using the curricular spider‐web framework. Results: The review shows the variation in CBL implementation at the course and project levels. CBL courses and projects shared the use of open‐ended, real‐world challenges as a starting point for student learning. However, they differed in the embeddedness of a challenge in specific courses and the focus of the learning, which ranged across knowledge acquisition, knowledge application, and development of transversal skills. CBL experiences also varied in terms of challenge characteristics, such as the link with global societal challenges, stakeholders' involvement, and multidisciplinarity. Similar difficulties and lessons learned were reported by teachers and students across the different examples of CBL implementation. Conclusions: CBL as a pedagogical approach in engineering education can promote student engagement with complex societal challenges within a real‐world context. However, there are limitations to the review and implications of the findings for educational research and practice. [ABSTRACT FROM AUTHOR]

Background & Objective: The COVID-19 pandemic has impacted medical education worldwide with several opportunities and challenges. This study aims to provide an overview of medical education's opportunities and challenges according to the experience of the COVID-19 pandemic in order to guide future endeavors in conducting the teaching-learning process in post-COVID era support. Material & Methods: In this systematized review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, databases of PubMed, Cochrane, Scopus, Web of Science, and Eric, in addition to Google Scholar as a search engine, were searched to retrieve relevant original peer-reviewed, review, editorial, and commentary articles published from Dec 2019 to the end of Sep 2022. Results: As per the qualitative synthesis, a total of 29 articles were included from the 1534 records that were identified. Reviewing the included articles showed that most of the relevant studies were considered Medical and healthcare students (51.8%) at undergraduate level (72.5%) in University settings (62.1%). As per the qualitative synthesis, a total of 29 articles were included from the 1534 records that were identified. Reviewing the included articles showed that most of the relevant studies were considered Medical and healthcare students (51.8%) at undergraduate level (72.5%) in University settings (62.1%). On the other hand, post-COVID medical education opportunities have been grouped into four main categories, which are teaching and learning processes, psychological impact, accessibility and education equity, and management and administrative affairs. Post-COVID medical education opportunities also consist of four main categories: teaching-learning process, psychological impact, accessibility and education equity, and management and administrative affairs. Conclusion: Changes in teaching and learning processes in medical education caused by the COVID-19 pandemic created opportunities and caused important challenges that should be considered in the post-COVID era. In this regard, blended learning with the integration of technology using a flexible approach could be an effective recommendation. [ABSTRACT FROM AUTHOR]

Copyright of Retos, Revista de Ciencias Administrativas y Económicas is the property of Universidad Politecnica Salesiana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: This study aimed to evaluate the status, resource use, and challenges of the capture-based hatchery of black tiger shrimp (Penaeus monodon) (BTS). Methods: Data was obtained through the investigation of 15 broodstock fishing boats and 60 capture-based BTS broodstock hatcheries. Resource use index (RUI) of the capture-based BTS hatchery, calculated from 1,000 female brooders to produce 15-day-old post-larvae (PL15) (production efficiency of PL15, or PEPL15), was analysed. Results: The results indicated that the fishing boats captured an average of 5,900 brooders.boat-1.year-1, 20,856 kg of by catch.boat-1.year-1, and the PE-PL15 production of 937 million for 1,000 female brooders. In the hatchery stage, the use of larger body weight female brooders had benefits in terms of higher survival rate and better efficiency of labour use, Artemia cyst, and probiotic products, but it reduced the efficiency use of chemicals, pellets, and total tank volume of the hatchery. Discussion: There is increasing use of domesticated brooder sources, but wildcaught brooders still play an important role in producing low-cost PL15 for traditional shrimp farming systems, accounting for most farmed BTS production. Therefore, the certification of good practices should be implemented to capture-based BTS hatcheries for the reasonable use of this brooder resource to sustain BTS farming in Vietnam. [ABSTRACT FROM AUTHOR]

Introduction: Identifying and exploiting stewardship and financing challenges in Iran's health insurance system as an ecosystem is essential to achieving predetermined goals. This study aimed to determine the challenges and strategies in the Iranian health insurance ecosystem to provide relevant evidence to healthcare managers and policymakers to improve its functions and perform necessary reforms. Method: This qualitative study was conducted at the national level in Iran. Data were collected using semi-structured interviews and analyzed using the directed content analysis method. The study participants included managers and experts in health insurance and faculty of universities of medical sciences, who were selected by purposive sampling. Results: The challenges and strategies expressed by participants were categorized into two functions: stewardship and financing. Four main themes, ten subthemes, 22 challenges, and 24 strategies were identified in the stewardship function, along with three main themes, 12 subthemes, 17 challenges, and 16 strategies in the financing function. The major challenge in the Iranian health insurance ecosystem was the complexity and conflict of interests between multiple actors with different roles, which led to fragmentation, diverse structures, and a gap between other functions and objectives, hindering the effective functioning of the ecosystem. Conclusion: In order to deal with the challenges of the health insurance ecosystem, it is suggested to create a coherent insurance system through a single utility system, and by paying more attention to health-oriented services, the health insurance ecosystem becomes a health-oriented system instead of being treatment-oriented. In addition, in order to strengthen the governance of the country's health insurance ecosystem, the number of actors with multiple roles should be reduced and the roles of the actors should be clarified and separated in order to prevent conflicts of interest and structural corruption in this ecosystem. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Stroke is the property of Chinese Journal of Stroke Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Space-Integrated-Ground Information Networks is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During the COVID-19 pandemic, antibody-based vaccines targeting the SARS-CoV-2 spike glycoprotein were the focus for development because neutralizing antibodies were associated with protection against the SARS-CoV-2 infection pre-clinically and in humans. While deploying these spike-based vaccines saved millions of lives worldwide, it has become clear that the immunological mechanisms of protection against severe disease are multifaceted and involve non-neutralizing antibody components. Here, we describe a novel pan-sarbecovirus T-cell vaccine, ChAdOx1.COVconsv12, designed to complement and broaden the protection of spike vaccines. The vaccine immunogen COVconsv12 employs the two regions in the viral proteome most conserved among sarbecoviruses, which are delivered by replication-deficient vector ChAdOx1. It directs T cells towards epitopes shared among sarbecoviruses including evolving SARS-CoV-2 variants. Here, we show that ChAdOx1.COVconsv12 induced broad T-cell responses in the BALB/c and C57BL/6 mice. In the Syrian hamster challenge model, ChAdOx1.COVconsv12 alone did not protect against the SARS-CoV-2 infection, but when co-administered with 1/50th of the ChAdOx1 nCoV-19 spike vaccine protective dose, faster recovery and lower oral swab viral load were observed. Induction of CD8+ T cells may decrease COVID-19 severity and extend the T-cell response coverage of variants to match the known (and as yet unknown) members of the β-coronavirus family. [ABSTRACT FROM AUTHOR]

Modified atmosphere package (MAP), as a practical, economic, and easy to operate food package technique, has experienced a rapid development in both scientific and industrial communities. In recent years, given the superiority of super-atmospheric O2 (SO) MAP in preserving fruits and vegetables relative to low O2 and/or high CO2 MAP, SO MAP is back on the radar of researchers. This paper systematically reviews recent development on application of SO MAP and improved strategies to fruit and vegetable preservation in the last 15 years, possible mechanisms concerning their positive and negative effects, and challenges and future perspectives for SO MAP. The present work can provide a theoretical basis and technique reference for achieving a better effectiveness on fruit and vegetable preservation in the practical application. [ABSTRACT FROM AUTHOR]

Remote sensing is essential in construction management by providing valuable information and insights throughout the project lifecycle. Due to the rapid advancement of remote sensing technologies, their use has been increasingly adopted in the architecture, engineering, and construction industries. This review paper aims to advance the understanding, knowledge base, and practical implementation of remote sensing technologies in the construction industry. It may help support the development of robust methodologies, address challenges, and pave the way for the effective integration of remote sensing into construction management processes. This paper presents the results of a comprehensive literature review, focusing on the challenges faced in using remote sensing technologies in construction management. One hundred and seventeen papers were collected from eight relevant journals, indexed in Web of Science, and then categorized by challenge type. The results of 44 exemplary studies were reported in the three types of remote sensing platforms (satellite, airborne, and ground-based remote sensing). The paper provides construction professionals with a deeper understanding of remote sensing technologies and their applications in construction management. The challenges of using remote sensing in construction were collected and classified into eleven challenges. According to the number of collected documents, the critical challenges were shadow, spatial, and temporal resolution issues. The findings emphasize the use of unmanned airborne systems (UASs) and satellite remote sensing, which have become increasingly common and valuable for tasks such as preconstruction planning, progress tracking, safety monitoring, and environmental management. This knowledge allows for informed decision-making regarding integrating remote sensing into construction projects, leading to more efficient and practical project planning, design, and execution. [ABSTRACT FROM AUTHOR]

Cancer remains a worldwide problem, and new treatment strategies are being actively developed. Peptides have the characteristics of good biocompatibility, strong targeting, functional diversity, modifiability, membrane permeable ability, and low immunogenicity, and they have been widely used to construct targeted drug delivery systems (DDSs). In addition, peptides, as endogenous substances, have a high affinity, which can not only regulate immune cells but also work synergistically with drugs to kill tumor cells, demonstrating significant potential for application. In this review, the latest progress of polypeptides-based nanocarriers in tumor therapy has been outlined, focusing on their applications in killing tumor cells and regulating immune cells. Additionally, peptides as carriers were found to primarily provide a transport function, which was also a subject of interest to us. At the end of the paper, the shortcomings in the construction of peptide nano-delivery system have been summarized, and possible solutions are proposed therein. The application of peptides provides a promising outlook for cancer treatment, and we hope this article can provide in-depth insights into possible future avenues of exploration. [ABSTRACT FROM AUTHOR]

This research paper aimed to identify the level of psychological hardiness, the level of death anxiety, and the level of existential vacuum among the elderly, also the role of the predictive ability of death anxiety and existential vacuum in the psychological hardiness of the elderly at the governorates of Tafilyah and Ma'an in light of the Corona pandemic in Jordan. The descriptive-analytical approach was utilized. sample consists (500) elderly, that were selected by a simple random approach. Then the needed statistical measure was operated to achieve the required results. The results indicated a low level of psychological hardiness, a high level of death anxiety, and an existential vacuum in the elderly. The results show a suitable predictive ability for each of death anxiety and the existential vacuum in reducing psychological hardiness. The research paper recommended the necessity of rehabilitating the elderly in Jordan regarding the mental and psychological aspects. [ABSTRACT FROM AUTHOR]

Although research has investigated how appraisals are linked with categories of emotions (e.g. pleasant and unpleasant emotions) in sport, research into how stress appraisal components are associated with specific discrete emotions commonly experienced in sport has received scant attention. This study examined how pre-performance stress appraisals were related to pre-performance anger, anxiety, dejection, excitement, and happiness. Athletes (N = 458) completed measures of pre-performance stress appraisals and emotions in relation to their latest competitive performance. Path analyses revealed challenge appraisal was positively linked to pleasant emotions, and threat appraisal with unpleasant emotions. Specific emotions also possessed discrete links with appraisal components. For example, uncontrollable-by-anyone appraisal was positively linked with anger and dejection but inversely linked with anxiety. Moreover, controllable-by-others appraisal was positively associated, and controllable-by-self appraisal was negatively associated, with anxiety. Excitement and happiness were similarly related with appraisal components. However, controllable-by-self appraisal was positively and more strongly associated with excitement, whereas controllable-by-others appraisal was also positively and directly linked with happiness. These findings highlight how stress appraisals are linked with common emotions in sport and offer applied implications for coaches, sport psychologists and athletes regarding ways that could help regulate pre-performance emotions in sport. [ABSTRACT FROM AUTHOR]

Enhancing awareness of personal cleanliness and antibacterial resistance has intensified the antibacterial substance request on consumable products. Antibacterial agents that have been commercialized nowadays are produced from inorganic and non-renewable substances. This provides several drawbacks, particularly against health and environmental issues. Therefore, many scientists work on substituting fossil-fuel-based antibacterial agents with natural ones such as from biomass. Biomass derivatives, natural abundances of biopolymers in the world, amount to major compounds including polysaccharides (cellulose, hemicellulose, and chitosan) and polyphenol (tannin and lignin) substances which are capable to combat the growth of Gram-positive bacteria and Gram-negative bacteria. To date, no report focuses on a deep understanding of antibacterial properties derived from biomass and the internal and external factors effects. This work provides that gap because comprehensive knowledge is necessary before applying biomass to the products. The potency of biomass derivatives as antibacterial additives is also summarized. Basic knowledge of antibacterial characteristics to the application in products is highlighted in this review. Besides, the discussion about challenges and future perspectives is also delivered. [ABSTRACT FROM AUTHOR]

Background and Aims: Children and neonates are more susceptible to diseases and are a vulnerable group in medication administration (MA). Nurses interact directly with patients, ensuring safety and preventing unintended outcomes. Health Information Technology (HIT) has transformed health care, aiding nurses in decision‐making and treatment responses. Despite its benefits, technology presents challenges that must be overcome to facilitate the nursing practice. Therefore, the present study aimed to explore the barriers to HIT use in the process of MA in children and neonates in a developing country. Methods: Semi‐structured face‐to‐face interviews were conducted with 22 health care professionals across seven pediatric and neonatal settings. Also, observations were made of these settings for 3 weeks. A qualitative analysis was performed using the conventional content analysis method, recommended by Colaizzi's seven‐step approach. Results: The results showed that the most significant barriers to adopting technology in MA process could be classified into two main categories: "inappropriate management approaches" with two sub‐categories ("Managers' reluctance to adopt new technology", "lack of adequate budget for hardware resources"), and "resistance to change" with two sub‐categories ("A desire to use conventional (traditional) approaches in care", "cultural issues and impracticality of providing some specialized technology services"). Conclusion: The findings revealed MA process complexities, which have been insufficiently examined in the current literature. We have highlighted the need for improved "effectiveness of HIT systems in administering medication processes, budget for hardware resources, and managers" interest in using new technology. The present findings can guide the development of more effective and user‐friendly HIT systems in pediatric and neonatal care settings. [ABSTRACT FROM AUTHOR]

With the continuous surge of production data in the field of oil exploration and development, the difficulty of integration and analysis is increasing, and manual analysis methods are difficult to meet the development needs of oil and gas fields on site. Machine learning can accurately and efficiently process data, and is a key technology in the field of data analysis and optimization. Utilizing machine learning to solve difficult problems in oil and gas field development has become the main focus of the industry. However, due to limitations in standardization construction, sample library establishment, and on-site integration, there are still many challenges and shortcomings in the application of machine learning in the field of oil exploration and development. In the future, efforts should be made to strengthen the standardization construction of machine learning, improve the data processing ability of deep learning algorithms, and pro-mote interdisciplinary research in the field of deep machine learning. Through multiple approaches, we can jointly promote the significant development of machine learning in the oil and gas field industry. [ABSTRACT FROM AUTHOR]

Copyright of Petroleum Geology & Oilfield Development in Daqing is the property of Editorial Department of Petroleum Geology & Oilfield Development in Daqing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Fungi-mediated synthesis of Gold nanoparticles (AuNPs) has advantages in: high efficiency, low energy consumption, no need for extra capping and stabilizing agents, simple operation, and easy isolation and purification. Many fungi have been found to synthesize AuNPs inside cells or outside cells, providing different composition and properties of particles when different fungi species or reaction conditions are used. This is good to produce AuNPs with different properties, but may cause challenges to precisely control the particle shape, size, and activities. Besides, low concentrations of substrate and fungal biomass are needed to synthesize small-size particles, limiting the yield of AuNPs in a large scale. To find clues for the development methods to solve these challenges, the reported mechanisms of the fungi-mediated synthesis of AuNPs were summarized. The mechanisms of intracellular AuNPs synthesis are dependent on gold ions absorption by the fungal cell wall via proteins, polysaccharides, or electric absorption, and the reduction of gold ions via enzymes, proteins, and other cytoplasmic redox mediators in the cytoplasm or cell wall. The extracellular synthesis of AuNPs is mainly due to the metabolites outside fungal cells, including proteins, peptides, enzymes, and phenolic metabolites. These mechanisms cause the great diversity of the produced AuNPs in functional groups, element composition, shapes, sizes, and properties. Many methods have been developed to improve the synthesis efficiency by changing: chloroauric acid concentrations, reaction temperature, pH, fungal mass, and reaction time. However, future studies are still required to precisely control the: shape, size, composition, and properties of fungal AuNPs. [ABSTRACT FROM AUTHOR]

A change in the way Indian shows and television shows are produced may be seen in the release of Sacred Games, the first Indian original series on Netflix. It is essential to understand this series because it has generated a market for Indian television shows on Netflix in India. Even though the relationship between cops and gangsters in a city is a well-known one, this show's portrayal of it takes the form of seasons and episodes, with the city's portrayal being the main focus to help the viewer understand it. With regard to gendered politics, women, patriarchy, and intergroup violence, it discusses how criminals, politicians, the mafia, businessmen, and the Bombay Police are depicted. Also, it focuses on contentious issues like the dynamic between lawmakers and lawbreakers, religious violence, staged encounters, and bribery in the entertainment sector. Because of its distinctive portrayals of cities, people, topics, and plot lines, and because of its narrative approach, the series Sacred Games stands out from the competition. An extensive content analysis technique is employed for each episode of Sacred Games to comprehend the web series as a whole. This research paper examines the distinctive elements of the Indian television series Sacred Games, including its unique storytelling style, character depiction, and storyline structure. [ABSTRACT FROM AUTHOR]

Antibiotic resistance, a known global health challenge, involves the flow of bacteria and their genes among animals, humans, and their surrounding environment. It occurs when bacteria evolve and become less responsive to the drugs designated to kill them, making infections harder to treat. Despite several obstacles preventing the spread of genes and bacteria, pathogens regularly acquire novel resistance factors from other species, which reduces their ability to prevent and treat such bacterial infections. This issue requires coordinated efforts in healthcare, research, and public awareness to address its impact on human health worldwide. This review outlines how recent advances in gene editing technology, especially CRISPR/Cas9, unveil a breakthrough in combating antibiotic resistance. Our focus will remain on the relationship between CRISPR/cas9 and its impact on antibiotic resistance and its related infections. Moreover, the prospects of this new advanced research and the challenges of adopting these technologies against infections will be outlined by exploring its different derivatives and discussing their advantages and limitations over others, thereby providing a corresponding reference for the control and prevention of the spread of antibiotic resistance. [ABSTRACT FROM AUTHOR]

Background: A challenge to pre-hospital emergency care is any barrier or obstacle that impedes quality pre-hospital care or impacts community pre-hospital utilization. The Addis Ababa Fire and Disaster Risk Management Commission (AAFDRMC) provides pre-hospital emergency services in Addis Ababa, Ethiopia. These services operate under a government-funded organization that delivers free emergency services, including out-of-hospital medical care and transportation to the most appropriate health facility. This study aimed to assess the challenges of pre-hospital emergency care at the Addis Ababa Fire and Disaster Risk Management Commission in Addis Ababa, Ethiopia. Methods: A qualitative descriptive study was conducted from November 20 to December 4, 2022. Data were collected through in-depth, semi-structured interviews with 21 experienced individuals in the field of pre-hospital emergency care, who were selected using purposeful sampling. A thematic analysis method was used to analyze the data. Results: This study includes twenty-one participants working at the Addis Ababa Fire and Disaster Risk Management Commission. Three major themes emerged. The themes that arose were the participants' perspectives on the challenges of pre-hospital emergency care in Addis Ababa, Ethiopia. Conclusion and recommendation: The Fire and Disaster Risk Management Commission faces numerous challenges in providing quality pre-hospital emergency care in Addis Ababa. Respondents stated that infrastructure, communication, and resources were the main causes of pre-hospital emergency care challenges. There has to be more focus on emergency management in light of infrastructure reform, planning, staff training, and education, recruiting additional professional power, improving communication, and making pre-hospital emergency care an independent organization in the city. [ABSTRACT FROM AUTHOR]

Background: This study aims to investigate international measures for pandemic control in the workplace based on guidelines from international organizations to learn from their experiences. Methods: We conducted a qualitative study using content analysis. The search method involved reviewing published guidelines on preventing and responding to the COVID-19 pandemic in workplaces. After the screening process, ten guidelines were included in the content analysis. During the analysis, 200 meaning codes, 49 subcategories, and eleven categories were identified. Trustworthiness criteria were utilized to ensure the accuracy and strength of the findings. Results: Eleven categories of international content during the COVID-19 pandemic were legal requirements and duties of employees and employers, structural and program changes, risk assessment, risk communication, information and training, internal and external consultation and cooperation, provision of facilities and tools for workplace hygiene, special conditions, special groups, closing and reopening workplaces, reducing contact and exposure and mental health. Conclusions: Protecting employees during a pandemic requires a multifaceted approach and strong advocacy. The operational plan for pandemic control should be developed based on the level of risk, with support tailored to employees' conditions and needs. Cooperation among international organizations is essential to develop a standardized plan and issue comprehensive guidelines in response to health emergencies with a global perspective and local implementation, drawing from the lessons learned during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Since its establishment, the Islamic Republic of Iran has faced various political challenges. In some instances, certain crises appeared sufficient to topple the regime, yet through crisis management by Iran's leaders, conditions eventually led to the stabilization of the revolution. The present study aims to explore the methods of the Supreme Leader and the model for addressing the political challenges of the Islamic Republic. The main research question is: ‘Does the Supreme Leader have a comprehensive model for managing political crises?’ To this aim was used qualitative descriptive method, employing document analysis and targeted sampling through interviews with experts. Content analysis of these interviews has also been conducted to identify the components of the research. Results: The study of methods and actions within the framework of crisis leadership was conducted based on indicators of control, mobilization, spiritual influence, and informed management of events. After interviews with experts, the findings were categorized into four levels: Preventive measures and challenge identification, decision-making, confrontation and management of challenges and crises, shaping awareness and conceptualization, learning, and delineating crisis lessons. Key components include: Macro-level policymaking, information assessment and awareness, management of destabilizing events, decisive confrontation with crisis inducing factors and conditions, leadership of public opinion, clarification of citizens’ and institutions’ responsibilities, utilization of the spiritual influence of the Supreme Leader, discourse formation, conceptualization, education, foresight, and further elaboration. [ABSTRACT FROM AUTHOR]

Objective: Exploring the challenges experienced by the pre-hospital emergency personnel to prevent the secondary injuries and provide more effective services to children can be helpful. This study aims to explain the safety challenges of children in the pre-hospital emergencies. Methods: This qualitative study, which was conducted with the content analysis approach, was a semistructured, and in-depth data collection process with the field notes for pre-hospital emergency personnel in Dezful city in 2022. Sampling was done in a targeted and available manner. The sampling process continued until the data saturation was reached. The trustworthiness of data was improved by reviewing and revising the data, experience and expertise of the interviewer, review of research participants and researchers. The research data, including interview texts and field notes, were divided into the semantic units, and then summarized by compression, and then abstracted in the order of subclasses, main classes, and finally themes. Results: Qualitative data analysis of interviews and notes led to the extraction of eight themes, which expressed the nature of children's safety challenges in the pre-hospital emergency: the lack of pre-hospital equipment for children, physical and mental characteristics of children, the lack of safety of vehicles for children, the lack of clinical skills of personnel for children, anxiety and non-cooperation of parents, operational and legal problems, the lack of attention to professional responsibility and high work pressure in children's missions. Conclusion: This study's results showed that identifying children's safety challenges for pre-hospital emergency personnel can help better understand the care needs of this age group and help managers plan in order to reduce children's safety challenges in the pre-hospitalmissions. [ABSTRACT FROM AUTHOR]

Copyright of Bulletin of the Chinese Academy of Sciences / Chung-kuo ko Hsueh Yuan Yuan Kan is the property of Institutes of Science & Development, Chinese Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

International Construction Joint Ventures (ICJVs) offer benefits to both local and foreign partners. However, their failure rates tend to be high, leading to poor ICJV performance. Effective Project Management (PM) is considered a means to resolve challenges in a construction project. Therefore, this research aims to address the challenges in ICJV projects within the Sri Lankan construction industry through PM practices to establish successful ICJVs. The research adopted a mixed-method approach. A preliminary survey was conducted to validate the challenges in the Sri Lankan context. After that, challenges were ranked based on their significance level using the Relative Importance Index (RII) method through a questionnaire survey. Then, Semi-structured interviews were conducted to identify the PM practices that can address significant challenges through code-based content analysis. The study revealed 38 challenges applicable to ICJVs and identified 88 PM practices for resolving 10 significant challenges out of the 38 identified in ICJV projects in Sri Lanka (SL). Finally, a framework was developed for successful ICJVs by addressing challenges through PM practices. This study marks the first attempt to establish a framework for successful ICJVs by addressing challenges through PM practices in the Sri Lankan construction industry. [ABSTRACT FROM AUTHOR]

Copyright of Humanities Journal of University of Zakho (HJUOZ) is the property of Humanities Journal of University of Zakho and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: 3D printing, also known as additive manufacturing, is a rapidly advancing technology in the life sciences sector. Several countries, including the USA, Canada and Singapore, have established regulations for 3D printing of pharmaceutical products. The growing demand for personalized medical devices presents a significant challenge to traditional manufacturing methods. Materials and Methods: This study aims to provide a concise overview of the introduction, history and evolution of 3D printers, their development process and their role and guidelines and focus is on exploring regulatory parameters related to 3D printing in the United States, Canada and Singapore. The Food and Drug Administration (FDA) has issued guidance outlining its initial considerations for technical aspects specific to devices using additive manufacturing. The regulatory landscape of 3D-printed medical devices and biologics in the United States is discussed, emphasizing key challenges and considerations. Results and Discussion: A comparative analysis in Selected counties was conducted across various aspects, including user needs, design input, performance requirements, design processes, functional requirements, design output, verification and validation, bio-printing regulatory perspectives, standardization and certification. Conclusion: As additive manufacturing technology advances, 3D bio-printing has emerged as an efficient tool for regenerative medicine and tissue engineering, integrating computer-aided manufacturing into healthcare delivery. The applications of 3D printing in the healthcare field extend to creating and implementing patient-specific solutions. [ABSTRACT FROM AUTHOR]

Purpose: Creating value in family firms is considered a challenge, especially with the entry of the second generation. It is important to identify the obstacles and solutions to the challenges in the value creation process. This article answers the question of what factors prevent the success of the G1 and G2 in value creation and what solutions are there to deal with these challenges. In this research, the construct of "5 management levers at the corporate analysis level and the capabilities of G1 and G2 at the level of family analysis" were used. This research identifies and describes some of the barriers firms face and solutions are provided in this field. Method: To investigate the above relationships, a literature review method and case study of 5 firms were used with 13 semi-structured interviews with G1 and G2 and experts in the publishing industry. After the theoretical saturation of the findings, they were matched with the theoretical views of the background, and finally, the resulting data were analyzed using the analytical method of Straus Corbin. Using the construct of "5 managerial levers (Crossan, 2010)and capabilities of G1 and G2 in solving value creation challenges (Soluk J. K., 2021)" at the level of corporate and family analysis, based on the findings of axial and selective coding, a descriptive model and a theoretical framework were presented. Results: The factors of solving conflicts and obstacles with the interaction of two generations, acceptance of G2 in the firm, succession and empowerment of the new generation and reducing the risk aversion of the G1 with the arrival of the new generation and specialists were recognized as the main categories. and the factors of creating vision and motivation and flexibility in G1, interactions and exchanging knowledge and ideas between two generations, changing management style, structure and systems by transferring management to the new generation and creating an innovative culture and changing culture with The arrival of G2 and specialists were recognized as twogeneration value creation solutions. [ABSTRACT FROM AUTHOR]

Background: Desmopressin (1-deamino-8-D-arginine vasopressin [DDAVP]) has demonstrated efficacy as a treatment option for patients with inherited bleeding disorders. Because of individuals' variable response to the medication, it is recommended to complete a challenge to document appropriate hemostatic response to the medication before recommending its use prior to surgical procedures or treatment of bleeding symptoms. The project aimed to reduce the errors in hemostatic response assessments for patients with bleeding disorders undergoing a DDAVP challenge (process outcome), particularly timing and number of blood samples drawn, from an error rate baseline of 36% to 0% by December 2021 and sustained for one year. Method: Plan-Do-Study-Act methodology was employed for this qualitative improvement initiative. Interventions designed and implemented included: an order set with medication doses and corresponding laboratory orders as clinically indicated for the bleeding disorder indication, clinical procedure guidelines for infusion nurses to follow, hemostasis nurse coordination of appointments with patients, and family education. Results: Baseline data on 22 patients who completed a DDAVP challenge demonstrated a 36% error rate not involving doses of medication administered. Errors encountered included improper timing of laboratory draw after DDAVP administration, incomplete laboratory evaluation, laboratory results displayed incorrectly due to testing orders released at once instead of in a sequential manner. These interventions resulted in a reduction of DDAVP challenge errors to 0% that were sustained for one year. Conclusion: Improvement in procedural medication administration and appropriate laboratory evaluation of patients undergoing a DDAVP challenge leads to a complete and reliable assessment of hemostatic response following medication administration. [ABSTRACT FROM AUTHOR]

Integrated ocean management (IOM) aligns with the United Nations' Sustainable Development Goals (SDGs) and serves as a crucial strategy for promoting the enduring health of marine ecosystems and the sustainable utilization of marine resources. An analysis of the evolution of China's integrated ocean management policy (IOMP) is crucial for providing valuable guidance in achieving sustainable growth in marine management and the marine economy for both China and other coastal nations worldwide. This paper studies the evolution characteristics, challenges, and prospects of IOMP in China since 1978 using content analysis. The findings indicate that the evolution of IOMP can be categorized into four stages: the germination period (1978–1998), the construction period (1999–2009), the systematization period (2010–2017), and the strategization period (2018–present), based on the state of international marine management. The IOMP has transitioned over time from its initial emphasis on resource development during the germination period to a strategization period that prioritizes the full development of all parts of the system. However, the ultimate goal has consistently been to achieve harmonious coexistence between people and the sea. China's IOMP has experienced a progressive development; nevertheless, it continues to encounter obstacles such as the pressing requirement to revise sea-related policies and the absence of policy alignment. The objective of this paper is to explore the evolution, challenges, and prospects of China's IOMP to better improve the land–sea coordination policy, strengthen international judicial cooperation. and provide effective policy reference for other maritime countries. [ABSTRACT FROM AUTHOR]

Smart buildings play a key role in the complex ecosystem of cities and are often subject to barriers that limit their development. Although identifying these barriers is fundamental to creating an enabling environment for this segment's expansion, few works aim to identify these challenges. This work has two main objectives: (1) to research the main barriers limiting the development of new smart building projects and (2) to prioritize these barriers from the perspective of professionals with experience in the field. We adopted an exploratory approach common in research that focuses on identifying and prioritizing variables related to a phenomenon, which is based on two main actions: obtaining information through a careful literature review and consulting professionals who work in the concerned field. The results showed that professionals assessed the 23 barriers identified through bibliographic research as important, with the most important being related to lack of qualified professionals, shortage of government policies, higher initial and construction costs, macroeconomic barriers and access to financing, high cost of intelligent systems and technologies, regulatory barriers, lack of knowledge about the current and potential benefits of smart buildings, and more complex design and construction. [ABSTRACT FROM AUTHOR]

Copyright of University of Sharjah Journal of Law Sciences (JLS) is the property of University of Sharjah - Scientific Publishing Unit and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Science & Technology & Economy is the property of Grain Science & Technology & Economy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tibetan-speaking patients seeking care in predominantly Mandarin-speaking healthcare settings frequently face communication barriers, leading to potential disparities and difficulties in accessing care. To address this issue, we translated, culturally adapted, and validated the Numerical Pain Rating Scale (NPRS) and the Global Rating of Change (GRoC) into Tibetan (NPRS-Tib and GRoC-Tib), aiming to facilitate cross-linguistic and cross-cultural interactions while examining potential challenges in the adaptation process. Using standard translation-backward translation methods, expert review, pilot testing, and validation through a cross-sectional study with a short-term longitudinal component, we engaged 100 Tibetan patients with musculoskeletal trauma for psychometric validation, including 37 women (aged 22–60 years, mean age 39.1 years). The NPRS-Tib and GRoC-Tib exhibited outstanding psychometric properties, with an Intraclass Correlation Coefficient (ICC) of 0.983 for NPRS-Tib indicating superb test–retest reliability, and expert review confirming good content validity for both instruments. A Spearman's correlation coefficient (Rho) of -0.261 (P = 0.0087) revealed a significant, albeit weak, correlation between changes in NPRS-Tib scores and GRoC-Tib scores. The adaptation process also presented notable challenges, including translation discrepancies from translators' diverse backgrounds and levels of expertise, ambiguity in scale options, and the lack of established tools for criterion validity assessment in Tibetan. [ABSTRACT FROM AUTHOR]

According to the challenge-hindrance model of stress (CHM), employees' appraisal of potential stressors may split into two distinct dimensions that either interfere with or enhance employees' functioning. This work expands the CHM framework by investigating whether employees' appraisal of the challenge-hindrance of COVID-19 predicts job insecurity and performance. It explores the relationship between the appraisal of the challenge-hindrance of COVID-19 and employees' job performance while incorporating the mediating role of job insecurity and the moderating role of COVID-19 Fear. Data were collected from 257 employee-supervisor dyads. As hypothesized, perceived job insecurity mediated the associations between COVID-19 hindrance and challenge appraisals and job performance. Fear of COVID-19 further moderated the association between hindrance appraisal and job performance and enhanced the indirect relationships between hindrance, job insecurity, and job performance. Unlike most studies that focus only on the adverse outcomes of COVID-19 stressors, this study examines the potential positive effects of challenge appraisals of the COVID-19 crisis. [ABSTRACT FROM AUTHOR]

Copyright of e-Education Research is the property of Northwest Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: Ktrans$$ {K}^{\mathrm{trans}} $$ has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for Ktrans$$ {K}^{\mathrm{trans}} $$ quantification are standardized. The ISMRM Open Science Initiative for Perfusion Imaging–Dynamic Contrast‐Enhanced (OSIPI‐DCE) challenge was designed to benchmark methods to better help the efforts to standardize Ktrans$$ {K}^{\mathrm{trans}} $$ measurement. Methods: A framework was created to evaluate Ktrans$$ {K}^{\mathrm{trans}} $$ values produced by DCE‐MRI analysis pipelines to enable benchmarking. The perfusion MRI community was invited to apply their pipelines for Ktrans$$ {K}^{\mathrm{trans}} $$ quantification in glioblastoma from clinical and synthetic patients. Submissions were required to include the entrants' Ktrans$$ {K}^{\mathrm{trans}} $$ values, the applied software, and a standard operating procedure. These were evaluated using the proposed OSIPIgold$$ \mathrm{OSIP}{\mathrm{I}}_{\mathrm{gold}} $$ score defined with accuracy, repeatability, and reproducibility components. Results: Across the 10 received submissions, the OSIPIgold$$ \mathrm{OSIP}{\mathrm{I}}_{\mathrm{gold}} $$ score ranged from 28% to 78% with a 59% median. The accuracy, repeatability, and reproducibility scores ranged from 0.54 to 0.92, 0.64 to 0.86, and 0.65 to 1.00, respectively (0–1 = lowest–highest). Manual arterial input function selection markedly affected the reproducibility and showed greater variability in Ktrans$$ {K}^{\mathrm{trans}} $$ analysis than automated methods. Furthermore, provision of a detailed standard operating procedure was critical for higher reproducibility. Conclusions: This study reports results from the OSIPI‐DCE challenge and highlights the high inter‐software variability within Ktrans$$ {K}^{\mathrm{trans}} $$ estimation, providing a framework for ongoing benchmarking against the scores presented. Through this challenge, the participating teams were ranked based on the performance of their software tools in the particular setting of this challenge. In a real‐world clinical setting, many of these tools may perform differently with different benchmarking methodology. [ABSTRACT FROM AUTHOR]

The start of higher vocational education and training is a new stage for students with a challenge between theoretical classes and the new expectations and demands of companies during the internship period. To understand some of the implications of stress on cyberloafing, we can distinguish between stress perceived as an obstacle that can be overcome – challenge stress – or as a threat that can block work performance – obstacle stress – and stress perceived as an obstacle that can be overcome – challenge stress – or as a threat that can block work performance – obstacle stress-. The aim of this research is to find out the relationships between challenge-obstacle stress in Cyberloafing, as well as the moderating effect of Smartphone Addiction and Maladaptive. In this study, the Challenge-Hindrance Stressors, Smartphone addiction scaleshort version (SAS-SV) instrument, the Maladaptive subscale of the Cognitive Emotional Regulation Questionnaire (CERQ) and Cyberloafing were applied to 403 upper-level vocational training students from different secondary schools in all provinces of the autonomous community of Andalusia, Spain, distributed throughout the provinces that make up this autonomous community. The findings show that students’ challenge stressors do not increase Cyberloafing, enabling them to cope with the academic demands and work challenges during the theory and internship period. On the contrary, obstacle stressors generate stressful situations that undermine the acquisition of objectives and development of academic competences. In our research we observe that challenge-obstacle stressors have a disparate influence on cyberloafing. Challenge stressors are negatively related to Maladaptive. The same is not true for obstacle stressors. [ABSTRACT FROM AUTHOR]

The construction industry accounts for approximately one-third of the total waste generation globally. With the United Nations projecting a population increase of 2 billion within the next three decades, there is a heightened demand for building stock, generating unprecedented volumes of construction and demolition waste (CDW). To combat this, circular economy strategies are purported to help alleviate the prevailing situation. But a number of challenges are jeopardizing their implementation in the construction industry and preventing from achieving the UN Sustainable Development Goals, net zero carbon and zero avoidable waste targets. This paper systematically analyzes 54 research articles, published in the past decade within major peer-reviewed English-language scholarly publications in the form of a systematic research review. In doing so, it aims to identify and classify the challenges that prevent improved CDW management by assimilating previous research results in support of a circular economy. The classification and analysis using a PESTLE model offers insights into gaps and differences between categories, as well as regions and countries. This initial step could contribute to a better understanding of these barriers, along with associated solutions, which could result in a significant reduction on the impact of construction activities, therefore facilitating the development of an effective circular economy in the sector. [ABSTRACT FROM AUTHOR]

How players react to failure remains an understudied area of games research. Previous work has shown that mastery orientation can effectively gauge how players will behave in response to failure in a video game. This study shows that after playing a challenging video game for two weeks, women who initially scored lower on this scale significantly increased, while men significantly decreased. No differences were found regarding how much they played, how often they failed, or their reactions to in-game failure. This suggests that this change is not rooted in their behavior, but in their perceptions of their ability to persist in these environments. These perceptions may have been influenced by well-documented stereotype biases that women and other individuals face entering video game communities. While this doesn't address the root cause, it suggests that the perception of their ability to persist through challenging games can change with exposure, relieving these held biases. [ABSTRACT FROM AUTHOR]