1. Differential WNT4 expression among various subtypes of moyamoya disease results in alterations of microtubule stability.
- Author
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He, Shihao, Zhou, Zhenyu, Zhang, Junze, Wang, Yanru, Liu, Ziqi, Hao, Xiaokuan, Wang, Xilong, Ye, Xun, Zhao, Yuanli, and Wang, Rong
- Subjects
GLYCOGEN synthase kinase ,ADENOMATOUS polyposis coli ,THORACIC aneurysms ,INTRACELLULAR tracking ,INTERNAL carotid artery ,TAU proteins - Abstract
This article discusses the findings of a study on moyamoya disease (MMD), a condition characterized by the occlusion of the intracranial internal carotid artery and the formation of collateral vessels. The study focuses on the differential protein metabolism among different subtypes of MMD and the role of WNT4 (wingless‐type MMTV integration site family member 4) in causing cellular impairments by reducing microtubule stability. The researchers used proteomic profiling and in vitro experiments to identify the differences in protein metabolism and explore the potential mechanisms of haemorrhagic MMD. The study suggests that overexpression of WNT4 may lead to decreased stability of cellular microtubules, which could contribute to the rupture and hemorrhage of moyamoya vessels. These findings provide new insights into the biomarkers and mechanisms of haemorrhagic MMD. [Extracted from the article]
- Published
- 2024
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