578 results on '"So, Franky"'
Search Results
2. Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma.
- Author
-
Patel, Hitarth V., Joshi, Jigna S., and Shah, Franky D.
- Abstract
Introduction: Oral cancer poses a significant burden on public health in India, with higher incidence and mortality rates. Despite advancements in treatment modalities, prognosis remains poor due to factors such as localized recurrence and lymph node metastasis, potentially influenced by cancer stem cells. Among signaling pathways implicated in CSC regulation, the Hedgehog pathway plays a crucial role in oral squamous cell carcinoma (OSCC). Material & methods: 97 OSCC patients' tissue samples were collected and subjected to RNA isolation, cDNA synthesis and quantitative real-time PCR to analyze PTCH1 and SMO expression. Protein expression was assessed through immunohistochemistry. Clinicopathological parameters were correlated with gene and protein expression. Statistical analysis included Pearson chi-square tests, co-relation co-efficient tests, Kaplan–Meier survival analysis and ROC curve analysis. Results: PTCH1 expression correlated with lymphatic permeation (p = 0.002) and tumor stage (p = 0.002), while SMO expression correlated with lymph node status (p = 0.034) and tumor stage (p = 0.021). PTCH1 gene expression correlated with lymph node status (p = 0.024). High PTCH1 gene expression was associated with shorter survival in tongue cancer patients. ROC curve analysis indicated diagnostic potential for PTCH1 and SMO gene and cytoplasmic SMO expression in distinguishing malignant tissues from adjacent normal tissues. Conclusion: PTCH1 and SMO play a crucial role in oral cancer progression, correlating with tumor stages and metastatic potential. Despite not directly influencing overall survival, PTCH1 expression at specific anatomical sites hints at its prognostic implications. PTCH1 and SMO exhibit diagnostic potential, suggesting their utility as molecular markers in oral cancer management and therapeutic strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Metaphyseal trauma of the lower extremities in major orthopedic surgery as an independent risk factor for deep vein thrombosis.
- Author
-
Hartono, Franky, Ananditya, Tessi, Augustinus, Yohanes, Hendra, and Gabriel, Nicholas
- Subjects
LEG injuries ,INJURY complications ,RISK assessment ,TOTAL hip replacement ,VENOUS thrombosis ,SCIENTIFIC observation ,FRACTURE fixation ,LOGISTIC regression analysis ,DESCRIPTIVE statistics ,ORTHOPEDIC surgery ,HEMIARTHROPLASTY ,SURGICAL complications ,LONGITUDINAL method ,ODDS ratio ,CONFIDENCE intervals ,DISEASE risk factors - Abstract
Purpose: Major orthopedic surgeries of the lower extremities, which heavily injure the metaphyseal region, are strongly associated with the risk of developing deep vein thrombosis (DVT). This study aims to investigate the role of metaphyseal trauma as an independent risk factor for DVT. Methods: Patients undergoing major orthopedic surgery of the hip and knee had their existing DVT risk factors recorded. Metaphyseal trauma was defined by the extent of bone injury during these surgeries. The samples were categorized into three surgery groups: total arthroplasty group (TA), hemiarthroplasty group (HA), and the open reduction internal fixation group (ORIF). Logistic regression test between significant existing risk factors and surgery groups determines the independent association between risk factors and DVT. Result: The study found a 24.8% incidence of asymptomatic DVT in patients undergoing major orthopedic surgeries, with the highest prevalence (37.2%) in TA, which had the largest extent of metaphyseal trauma and the least existing DVT risk factors. TA showed 6.2 OR and 95% CI (p = 0.036) compared to the other existing risk factor in relation to DVT incidence. Conclusion: Metaphyseal bone trauma in the hip and knee major orthopedic surgery is an independent risk factor for deep vein thrombosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Temporal Dynamics of Airborne Concentrations of Ganoderma Basidiospores and Their Relationship with Environmental Conditions in Oil Palm (Elaeis guineensis).
- Author
-
López-Vásquez, Juan Manuel, Castillo, Sandra Yulieth, Zúñiga, León Franky, Sarria, Greicy Andrea, and Morales-Rodríguez, Anuar
- Subjects
WIND speed ,SOLAR radiation ,GANODERMA ,BASIDIOSPORES ,AIR microbiology - Abstract
Basal Stem Rot (BSR), caused by Ganoderma spp., is one of the most important emerging diseases of oil palm in Colombia and is so far restricted to only two producing areas in the country. However, despite the controls established to prevent its spread to new areas, containment has not been possible. This study aimed to understand BSR's propagation mechanisms and related environmental conditions by measuring Ganoderma basidiospores' concentrations at various heights using four 7-day Burkard volumetric samplers in a heavily affected plantation. Meteorological data, including solar radiation, temperature, humidity, precipitation, and wind speed, were also recorded. Analysis revealed higher basidiospore concentrations below 4 m, peaking at 02:00 h, with increased levels towards the study's end. Spore concentrations were not directly influenced by temperature, humidity, or precipitation, but showed higher releases during drier periods. A significant correlation was found between wind speed and spore concentration, particularly below 1.5 m/s, though higher speeds might aid long-distance pathogen spread. This study highlights the complexity of BSR propagation and the need for continued monitoring and research to manage its impact on Colombia's oil palm industry. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Multivariate statistical analysis in ecological business models; an assessment of key factors in green companies in Colombia.
- Author
-
Rodriguez Franky, Franz Esteban
- Subjects
MULTIVARIATE analysis ,SMALL business ,BUSINESS models ,ENVIRONMENTAL responsibility ,SUSTAINABILITY ,CIRCULAR economy ,ECOLOGICAL models - Abstract
This article presents an analysis of the business behavior of small and medium-sized enterprises (SMEs) that consider themselves green in the city of Bogotá, Colombia. The study was carried out during the period 2021-2023 and focused on analysing the organisational actions focused on the sustainability of the business model of these companies. To this end, a multiple correspondence analysis was used, which allowed to evaluate the statistical dispersion between business variables in different functional areas. This analysis was carried out using the R model and following the stages of reading, modelling, and communicating results. Purpose: This article becomes relevant when analysing the behavior and organizational actions focused on the sustainability of the business models of ecological small and medium-sized enterprises (SMEs) in Bogotá, one of the main cities and economic engines of Colombia. Conducting a statistical assessment of these companies is critical to understanding the drivers of environmentally responsible practices, identifying patterns, challenges, and opportunities. The research contributes to filling a gap by providing an up-to-date, data-driven view of green SMEs in a Latin American urban context. In addition, the use of multiple correspondence analysis (MCA) provides a novel and rigorous approach to assess the dispersion and relationships between multiple business variables in different functional areas. This multivariate statistical analysis, performed using R software and following best practices, guarantees quality and reliability. Methodology: The methodology used in this study is based on data exploration, which allows to describe the research factors of mixed exploratory and descriptive characteristic, in which the hypothesis is validated through a statistical analysis of multiple correspondences. This multiple correspondence analysis allows the study of cross frequencies or contingency tables to analyse the simultaneity of the study. Results (mandatory): The results of the study indicate that there is a close relationship between the lifespan of SMEs and the implementation of sustainable business activities in their business model. SMEs with more than 3 years of presence in the market show corporate ecological strength, while those with less than three years of presence show low adherence to sustainability processes and actions. In total, the analysis was carried out in 32 of the 42 companies reported in Bogotá Research limitations: Some of the main limitations presented during the study focused on access to companies' information, the process of evaluating the sustainability of their processes and the dissemination of the results, since it is sensitive information for young companies that are venturing into a specialized market such as the green market. Originality: The origin of the study is based on identifying and describing the results found in the assessment or measurement of sustainability in the corporate processes of SMEs, analyzing the associated variables through a multiple correspondence allows identifying actions associated with sustainability [ABSTRACT FROM AUTHOR]
- Published
- 2024
6. Transcriptome analysis of anuran breeding glands reveals a surprisingly high expression and diversity of NNMT-like genes.
- Author
-
Schulte, Lisa M, Twomey, Evan, Jendras, Julia, Cruz-Elizalde, Raciel, and Bossuyt, Franky
- Subjects
GENE expression ,GLANDS ,GENES ,CHROMOSOME duplication ,TRANSCRIPTOMES ,SPIDER venom - Abstract
In many amphibians, males have sexually dimorphic breeding glands, which can produce proteinaceous or volatile pheromones, used for intraspecific communication. In this study we analyse two types of glands in the Mexican treefrog Ptychohyla macrotympanum (Hylidae)—large ventrolateral glands and small nuptial pads on their fingers—using histology, whole-transcriptome sequencing, and phylogenetic analyses. We found strong differences in glandular tissue composition and gene expression patterns between the two breeding gland types. In both glands we only found low expression of protein pheromone candidates. Instead, in the ventrolateral glands, gene expression was strikingly dominated by nicotinamide N -methyltransferase (NNMT)-like genes. The diversity of these genes was remarkably high, with at least 68 distinct NNMT-like genes. Our comparative phylogenetic analysis of the diversity of NNMT-like genes across vertebrates indicates that the extreme diversity of this gene is largely a frog-specific phenomenon and can be traced to large numbers of relatively recent gene duplications occurring independently in many lineages. The strong dominance and astonishing diversity of NNMT-like genes found in anurans in general, and in their sexually dimorphic breeding glands specifically, suggests an important function of NNMT-like proteins for anuran reproduction, possibly being related to volatile pheromone production. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Retrospective analysis of a flucloxacillin oral absorption test in patients requiring flucloxacillin therapy: results and determination of factors associated with adequate absorption.
- Author
-
Sanne, De Smet, de Cock, Pieter, Nick, Verougstraete, Franky, Buyle, Boelens, Jerina, and Huis in 't Veld, Diana
- Published
- 2024
- Full Text
- View/download PDF
8. Detection of Throat Disorders Based on Thermal Image Using Digital Image Processing Methods.
- Author
-
Satria Arisgraha, Franky Chandra, Rulaningtyas, Riries, Purwanti, Endah, and Ama, Fadli
- Subjects
THROAT diseases ,DIGITAL image processing ,CAMERAS ,DATA analysis ,ACCURACY - Abstract
Throat disorders are often considered trivial for some people, but if they are not treated immediately, they can result in more severe conditions and require a longer time to cure this disorder. Objective, safe and comfortable detection of throat disorders is important because throat disorders are an indication of inflammation which, if not treated immediately, can have negative consequences. This research aims to detect throat disorders based on thermal images using digital image processing methods. Image capture was carried out with the same color pallete range on the camera, namely 33°C-38°C. The image obtained is then cropped in the ROI, then the image is threshold with a gray degree of 190. Pixels that have a gray degree above 190 are converted to white, while those below the threshold are converted to black. Next, the percentage of each white and black area is calculated compared to the total ROI area. If the percentage of white area is greater than 38% compared to the area of the throat then it is identified as having a throat disorder, whereas if the percentage of white is less than 38% then it is identified as not having a throat disorder. The detection program created provides an accuracy of 87.5% on sample data of 8 test data. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Assessment of Fuelwood Consumption Pattern in Indigenous Communities in North-East India: A Case Study in Ukhrul District, Manipur, India.
- Author
-
LUNGLENG, PEIMI, VARAH, FRANKY, KHUMAN, Y. S. C., and SHIMRAH, TUISEM
- Published
- 2024
- Full Text
- View/download PDF
10. Metal‐Halide Perovskite Lasers: Cavity Formation and Emission Characteristics.
- Author
-
Moon, Jiyoung, Mehta, Yash, Gundogdu, Kenan, So, Franky, and Gu, Qing
- Published
- 2024
- Full Text
- View/download PDF
11. Asphalt Mix Compressive Stress-Strain Behavior: An Analytical and Experimental Study of Variable Influence.
- Author
-
Irianto, Tumpu, M., and Lapian, Franky E. P.
- Subjects
PLASTIC scrap ,PLASTIC bottles ,RENEWABLE energy sources ,COMPRESSION loads ,POLYETHYLENE terephthalate - Abstract
To address the excessive depletion of natural resources in Indonesia's civil construction sector, there's a rising trend in utilizing plastic waste from packaging, such as beverage bottles and plastic bags, alongside renewable energy sources like Modified Buton Asphalt (MBA). MBA serves as a partial substitute for both fine and coarse natural aggregates and nonrenewable energy sources like petroleum bitumen. This study aimed to investigate the effects of incorporating polyethylene terephthalate (PET) and polypropylene (PP) waste as partial substitutes for coarse and fine aggregates through experiments and t-tests. The objective was to determine how the stress-strain behavior of asphalt mixtures formed using MBA changed with the addition of this mixture. Additionally, compressive strength and elastic modulus were calculated under mixed compressive loads. PET and PP plastic waste replaced natural coarse and fine aggregates at three volume percentages: 1%, 2%, and 3%, with a PET:PP ratio of 50%. A manual grater was used to shred PET and PP plastic bottles into shredded plastic waste, which was retained in sieve no. 50 after sieving. The study found that adding PET, PP plastic, and MBA waste enhanced the asphalt mixture's mechanical strength and modified relevant variables, resulting in a more elastic and ductile behavior [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Cross and reciprocal effects on growth traits in a diallel mating involving four selected genetic groups of native chickens.
- Author
-
Telupere, Franky M.S.
- Published
- 2024
- Full Text
- View/download PDF
13. Development of quality indicators for antimicrobial stewardship in Belgian hospitals: a RAND – modified Delphi procedure.
- Author
-
Legros, Sylvie, Vanoverschelde, Anna, van Krieken, Jens, Debaveye, Yves, Versporten, Ann, Huis in 't Veld, Diana, Westelinck, Veerle, Briquet, Caroline, Vercheval, Christelle, Spriet, Isabel, Denis, Olivier, Magerman, Koen, De Schepper, Marc, and Buyle, Franky
- Published
- 2024
- Full Text
- View/download PDF
14. Malaria Vaccine Introduction in Cameroon: Early Results 30 Days into Rollout.
- Author
-
Ndoula, Shalom Tchokfe, Mboussou, Frank, Njoh, Andreas Ateke, Nembot, Raoul, Baonga, Simon Franky, Njinkeu, Arnaud, Biey, Joseph, Kaba, Mohamed II, Amani, Adidja, Farham, Bridget, Kouontchou Mimbe, Jean-Christian, Kouakam, Christian Armel, Volkmann, Konstantin, Dadjo, Crépin Hilaire, Habimana, Phanuel, and Impouma, Benido
- Subjects
MALARIA vaccines ,VACCINATION coverage ,VACCINATION status ,VACCINATION of children ,HEALTH facilities - Abstract
Cameroon introduced the malaria vaccine in its routine immunization program on 22 January 2024 in the 42 districts out of 200 that are among the most at risk of malaria. A cross-sectional analysis of the data on key vaccine events in the introduction roadmap and the vaccine uptake during the first 30 days was conducted. In addition to available gray literature related to the introduction of the malaria vaccine, data on the malaria vaccine uptake by vaccination session, collected through a digital platform, were analyzed. A total of 1893 reports were received from 22 January 2024 to 21 February 2024 from 766 health facilities (84% of overall completeness). Two regions out of ten recorded less than 80% completeness. As of 21 February 2024, 13,811 children had received the first dose of the malaria vaccine, including 7124 girls (51.6%) and 6687 boys (48.4%). In total, 36% of the children were vaccinated through outreach sessions, while 61.5% were vaccinated through sessions in fixed posts. The overall monthly immunization coverage with the first dose was 37%. Early results have shown positive attitudes towards and acceptance of malaria vaccines. Suboptimal completeness of data reporting and a low coverage highlight persistent gaps and challenges in the vaccine rollout. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. Characteristics of kesambi leaf torrefaction biomass.
- Author
-
Dethan, Jemmy J. S., Bale-Therik, Jublin F., Telupere, Franky M. S., Lalel, Herianus J. D., and Adisasmito, Sanggono
- Subjects
BIOMASS ,BIOMASS conversion ,BIOMASS energy ,LIQUEFIED gases ,ENERGY density ,EXPERIMENTAL design ,BIOMASS gasification - Abstract
Low energy density, high moisture content, irregular biomass shape (leaf biomass), low carbon content, and high tar content are the main limiting factors. These limitations can be overcome by providing pre-treatment before using biomass as an energy source or fuel. The most common pretreatment is torrefaction. Torrefaction will produce solid, liquid and gas substances. Torrefaction experiments carried out to meet research objectives are based on a Central Composite Design experimental design which is a 2-factor design. The Central Composite Design allows for the estimation of coefficients in a second-degree polynomial regression and quadratic response surface modeling. In this study, there are two factors, namely torrefaction temperature expressed as variable X1, and residence time variable X2. The torrefaction temperature used is 200°C - 300°C, and the residence time is 10 minutes to 20 minutes. The RSM interaction with 13 random runs by Minitab 18 software. Torrefaction of kesambi leaf biomass with a combination of temperature and torrefaction time produces good torrefaction products. The results showed that the optimum conditions for torrefied products based on calorific value response were obtained at a temperature of 300°C and a torrefaction time of 20 minutes with a torrefied product prediction. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. The characterization of anti-tuberculosis substances from Indonesian marine sponge Haliclona sp.
- Author
-
Maarisit, Wilmar, Untu, Sonny D., Lengkey, Yessie K., Mongi, Jeane, Kanter, Jabes W., Pareta, Douglas N., Sambou, Christel N., Tumbel, Silvana L., Montolalu, Friska M., Korua, Sandra A., and Tulungen, Franky R.
- Subjects
SPONGES (Invertebrates) ,MYCOBACTERIUM smegmatis ,BIOMEDICAL materials ,RAW materials ,MARINE organisms - Abstract
Indonesian waters contain bioactive compounds used as raw materials for medicines such as anti-cancer, anti-virus, and anti-tuberculosis. This study aimed to investigate bioactive compounds from marine organisms in North Sulawesi, Indonesia, with anti-tuberculosis properties. Furthermore, ethanol was used to extract the sponges, then fractionated using open column chromatographic. The HPLC was used to purify each fraction with an ODS column. Also, the compounds' identification and characterization were obtained using spectroscopic methods, such as 1D and 2D-NMR, IR, Mass spectroscopic, and UV. The Anti-Mycobacterium activity was tested using the disc diffusion methods. The findings revealed eight known substances, such as the haliclocyclamines A-C, and the cyclostellettamines A-C, E, and F. Mycobacterium smegmatis was prevented from developing by compounds 1 to 9 at a dosage of 10 mg/disc. Furthermore, compound 2 demonstrated a 17 mm/disc inhibition zone at 10 mg/disc concentration. This indicates that the compound has anti-tuberculosis properties. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
17. Analisis Implementasi Kebijakan Penyetaraan Jabatan Fungsional Pengelola Pengadaan Barang dan Jasa Di Lingkungan Kemendikbudristek.
- Author
-
Azhari, Puti Mutiara, Franky, and Utama, Zahera Mega
- Abstract
Copyright of Jurnal Ekonomi Manajemen Sistem Informasi (JEMSI) is the property of Dinasti Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
18. Nuclear receptor NURR1 functions to promote stemness and epithelial-mesenchymal transition in prostate cancer via its targeting of Wnt/β-catenin signaling pathway.
- Author
-
Zhang, Xingxing, Li, Haolong, Wang, Yuliang, Zhao, Hui, Wang, Zhu, and Chan, Franky Leung
- Published
- 2024
- Full Text
- View/download PDF
19. Optimisation of Particle Size of Torrefied Kesambi Leaf and Binder Ratio on the Quality of Biobriquettes.
- Author
-
Dethan, Jemmy J. S., Bale-Therik, J. F., Lalel, Herianus J. D., and Telupere, Franky M. S.
- Subjects
FUELWOOD ,SMOKED meat ,ADHESIVES ,PHENOL - Abstract
Se'i meat, a traditional smoked meat in East Nusa Tenggara Province of Indonesia, is processed using kesambi wood as biomass fuel. However, this usage poses a threat to kesambi tree sustainability. The study explores varying particle sizes and adhesive quantities for kesambi leaf biobriquettes. Experimental trials analyse the physical and chemical responses of biobriquettes, aiming for high fixed carbon content and calorific value. Results show that the optimal condition for making the bio-briquettes is torrefied kesambi leaf with a particle size of 60 mesh and 5% adhesive. It has resulted in their moisture content of 3.37%, ash content of 2.28%, volatile matter of 14.83%, fixed carbon of 79.53%, density of 0.57 g/cm3, calorific value of 15.91 MJ/kg, and total phenol content of 0.95 mgGAE/g. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. Impact of model-informed precision dosing in adults receiving vancomycin via continuous infusion: a randomized, controlled clinical trial.
- Author
-
Van Wynsberge, Glenn, Grootaert, Veerle, Buyle, Franky, Van Praet, Jens, Colman, Roos, Moors, Ine, Somers, Annemie, Veld, Diana Huis in 't, De Cock, Pieter, Bigler, Kim, Capiau, Andreas, Claus, Barbara, Degroote, Laure, De Keulenaer, Julie, Deryckere, Sabine, Deschepper, Lotte, De Smet, Sanne, De Smet, Veronique, Heus, Astrid, and Huys, Liesbeth
- Subjects
VANCOMYCIN ,ACUTE kidney failure ,CLINICAL trials ,ADULTS ,DRUG monitoring - Abstract
Background: Vancomycin is a commonly prescribed antibiotic to treat gram-positive infections. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area under the concentration-time curve (AUC) divided by the minimal inhibitory concentration (MIC) of the pathogen. However, in most countries, steady-state plasma concentrations are used as a surrogate parameter of target AUC/MIC, but this practice has some drawbacks. Hence, direct AUC-guided monitoring of vancomycin using model-informed precision dosing (MIPD) tools has been proposed for earlier attainment of target concentrations and reducing vancomycin-related nephrotoxicity. However, solid scientific evidence for these benefits in clinical practice is still lacking. This randomized controlled trial (RCT) aims to investigate the clinical utility of MIPD dosing of vancomycin administered via continuous infusion in hospitalized adults. Methods: Participants from 11 wards at two Belgian hospitals are randomly allocated to the intervention group or the standard-of-care comparator group. In the intervention group, clinical pharmacists perform dose calculations using CE-labeled MIPD software and target an AUC24h of 400 to 600 mg × h/L, whereas patients in the comparator group receive standard-of-care dosing and monitoring according to the institutional guidelines. The primary endpoint is the proportion of patients reaching the target AUC24h/MIC of 400–600 between 48 and 72 h after start of vancomycin treatment. Secondary endpoints are the proportion of patients with (worsening) acute kidney injury (AKI) during and until 48 h after stop of vancomycin treatment, the proportion of patients reaching target AUC24h/MIC of 400–600 between 72 and 96 h after start of vancomycin treatment, and the proportion of time within the target AUC24h/MIC of 400–600. Discussion: This trial will clarify the propagated benefits and provide new insights into how to optimally monitor vancomycin treatment. Trial registration: EudraCT number: 2021-003670-31. Registered June 28, 2021. ClinicalTrials.gov identifier: NCT05535075. Registered September 10, 2022. Protocol version 3, protocol date: April 21, 2023. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Spiers Memorial Lecture: Water at interfaces.
- Author
-
Devlin, Shane W., Bernal, Franky, Riffe, Erika J., Wilson, Kevin R., and Saykally, Richard J.
- Abstract
In this article we discuss current issues in the context of the four chosen subtopics for the meeting: dynamics and nano-rheology of interfacial water, electrified/charged aqueous interfaces, ice interfaces, and soft matter/water interfaces. We emphasize current advances in both theory and experiment, as well as important practical manifestations and areas of unresolved controversy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
22. Modeling the co-assembly of binary nanoparticles.
- Author
-
Mohanty, Saurav, Chen, Timothy, Chen, I-Te, So, Franky, and Chang, Chih-Hao
- Subjects
FAST Fourier transforms ,NANOPARTICLES ,FREQUENCY spectra ,FOURIER analysis - Abstract
In this work, we present a binary assembly model that can predict the co-assembly structure and spatial frequency spectra of monodispersed nanoparticles with two different particle sizes. The approach relies on an iterative algorithm based on geometric constraints, which can simulate the assembly patterns of particles with two distinct diameters, size distributions, and at various mixture ratios on a planar surface. The two-dimensional spatial-frequency spectra of the modeled assembles can be analyzed using fast Fourier transform analysis to examine their frequency content. The simulated co-assembly structures and spectra are compared with assembled nanoparticles fabricated using transfer coating method are in qualitative agreement with the experimental results. The co-assembly model can also be used to predict the peak spatial frequency and the full-width at half-maximum bandwidth, which can lead to the design of the structure spectra by selection of different monodispersed particles. This work can find applications in fabrication of non-periodic nanostructures for functional surfaces, light extraction structures, and broadband nanophotonics. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. Knowledge and attitudes of health professionals in Chile towards people living with human immunodeficiency virus: A cross-national survey.
- Author
-
Picón-Jaimes, Yelson Alejandro, Lozada-Martinez, Ivan David, Orozco-Chinome, Javier Esteban, Molina-Franky, Jessica, Bolaño-Romero, Maria Paz, and Fiorillo-Moreno, Ornella
- Published
- 2024
- Full Text
- View/download PDF
24. Greenhouse Gas Profiling to Increase Agricultural Mitigation Program Effectiveness in Indonesia.
- Author
-
Sondakh, Daniel S. I., Tulungen, Franky R., Kampilong, Jon K., Rumondor, Fadly S. J., and Kawuwung, Yolla S.
- Subjects
GREENHOUSE gases ,IRRIGATION ,RICE varieties ,ORGANIC farming - Abstract
This study aims to provide an inventory of greenhouse gas emissions in the agricultural sector, map the distribution of greenhouse gas emissions, and formulate effective mitigation strategies in Minahasa District. Primary data on rice field types, land processing systems, and fertilizer doses were obtained from the respondents. The method is the interview, and the instrument is the questionnaire. Secondary data is in the form of planting area and emission factor data. Data processing uses the Tier-1 method to obtain the amount of CO
2 , CH4 , and N2 O emissions. Spatial mapping of greenhouse gas emissions is done with the help of ArcMap. After that, the greenhouse gas mitigation strategy was formulated. Total agricultural greenhouse gas emissions: 3,578,093.27 t CO2 -eq/y, consists of emissions CH4: 71,711.87 t CO2 -eq/y; CO2 Fertilizer: 1,828,235.40 t/y; N2 0 Land Managed: 1,665,299.66 t CO2 -eq/y; and emission N2O Indirect: 12,846.33 t CO2 -eq/y. The largest gas emissions are CO2 (51.10 %) and N2 O Land Managed (46.54 %). The largest GHG-contributing is West Langowan District (285,165.25 t CO2 -eq/y). Various adaptation efforts are to adjust planting time and patterns and reduce the use of inorganic fertilizers. In contrast, mitigation efforts are implementing organic farming, regulating intermittent irrigation systems (dry and wet), using low-emission rice varieties, and utilizing soil improvement materials such as biochar. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
25. A clinicopathological exploration of Hedgehog signaling: implications in oral carcinogenesis.
- Author
-
Patel, Hitarth V., Joshi, Jigna S., and Shah, Franky D.
- Subjects
HEDGEHOG signaling proteins ,CANCER stem cells ,CELLULAR signal transduction ,ORAL cancer ,CARCINOGENESIS - Abstract
Introduction: Hedgehog Signaling, a basic cancer stem cell pathway, plays a major role during the embryonic development, is known to play a quiescent role in adults. However, aberrant activation of Hedgehog signaling in adults is known to play a role in cancer development. Hence, the aim of the study was to identify the role of Hedgehog signaling pathway in the Oral cancers. Materials and Methods: The expression of Hedgehog signaling pathway was evaluated in 124 patients through the quantitative real-time PCR. The association between the gene expression and clinico-pathological parameters were analyzed using the Pearson chi-square test and survival analysis was carried out using Kaplan-Meier analysis. Results: SHH and GLI1 was found to be significantly associated with the Lymph Node Status and SUFU was significantly associated with the Age. SMO and SUFU were found to have a worse prognosis in oral cancer patients. According to our findings, IHH plays a critical role in the activation of the HH signaling pathway in oral cancer. Conclusion: These findings back up the use of the Hedgehog signaling pathway as a biomarker for early disease prediction in oral cancer, as well as its role in tumor aggressiveness and invasiveness. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
26. Genetic divergence in common bean genotypes from the IRAD gene bank: morpho-agronomic characteristics, fungal and bacterial disease resistance, and opportunities for genetic improvement.
- Author
-
Kouam, Eric Bertrand, Djeugap-Fovo, Joseph, Meka-Sindje, Solange, Afsah, Nadia Mokia Mbinkar, Meyia, Arielle, Babagnack, Blaise Franky, Nouteka, Niky K. J., and Galani-Yamdeu, Joseph Hubert
- Subjects
COMMON bean ,BACTERIAL diseases ,DRUG resistance in bacteria ,MYCOSES ,GENOTYPES ,PLANT breeding - Abstract
For successful plant breeding in any crop species, the importance of diversity in the available germplasm population is known and established. Thirty-two common bean (Phaseolus vulgaris) genotypes from the IRAD gene bank in Cameroon were evaluated for divergence in terms of their morpho-agronomic traits, fungal disease resistance, and bacterial disease resistance to assess the opportunity for genetic improvement of the crop. The trait associations were estimated using correlation coefficients and genotypes were classified into groups using cluster and principal component analyses. Seven qualitative and 16 quantitative traits comprising growth, phenological, yield, and disease variables were evaluated in this study. The qualitative markers revealed the degree of polymorphism among the 32 common bean genotypes. The number of phenotypic classes per character (Na) ranged from 2 to 18, with an average of 5.14. The expected gene diversity (He) ranged from 0.37 to 0.93 (mean = 0.56). The number of effective phenotypic classes (Ne) ranged from 1.82 to 14.22, with a mean of 3.85. An extensive range of variation was evident for the majority of traits, highlighting their utility for characterizing common bean germplasm. Many qualitative traits, including seed coat color, seed shape, and seed size, and also some quantitative traits of economic importance including seed yield, were found to be highly variable within the collection, with the MAC55 genotype displaying the highest yield (32.65 g per plant). Four genotypes, namely MAC55, BOA-5-1M6, FEB 192, and Banguem showed resistance to the two main common bean diseases, angular leaf spot and common blight. We detected highly significant correlations among several traits related to yield. A high broadsense heritability was found for most of the quantitative traits. We carried out two-dimensional principal component analysis and used hierarchical clustering to group the analyzed germplasm according to their phenotypic similitudes. The evidence of agro-morphological diversity in the present collection and the identification of discriminant characters between the available germplasm through the use of PCA analysis have significant implications for establishing breeding schemes in common bean. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
27. Association of vitamin D receptor gene polymorphisms with breast cancer risk.
- Author
-
Patel, Shruti, Patel, Kinjal, Patel, Jayendra, Patel, Prabhudas, and Shah, Franky
- Subjects
VITAMIN D receptors ,BRCA genes ,DISEASE risk factors ,RESTRICTION fragment length polymorphisms ,GENETIC variation ,GENE transfection - Abstract
Background: Recent literature suggests that vitamin D signaling has a protective effect against breast cancer risk. Thus, the aim of the present study was to find the association of vitamin D receptor (VDR) gene polymorphisms with breast cancer risk. Materials and Methods: Fok1, Bsm1, Apa1, and Taq1 polymorphisms were performed by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method, and Poly A polymorphism was carried out using PCR-SSCP in 140 breast cancer patients and 155 controls. Results: Odds ratio was significantly higher in both homozygous variant genotypes (LL) of Poly A polymorphism of VDR (odds ratio [OR] = 5.42, 95% confidence interval [CI] = 1.19–23.31, P = 0.02) and heterozygous variant genotypes (SL) of Poly A polymorphism of VDR (OR = 3.89, 95% CI = 1.10–13.7, P = 0.03). Fok1, Bsm1, Apa1, and Taq1 polymorphisms of VDR gene were not significantly associated with breast cancer risk. Conclusion: Poly A polymorphism at the 3′ untranslated region (UTR) of VDR gene was significantly associated with breast cancer risk in West Indian population. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
28. Extremophilic microbial metabolism and radioactive waste disposal.
- Author
-
Butterworth, Sarah Jane, Barton, Franky, and Lloyd, Jonathan Richard
- Abstract
Decades of nuclear activities have left a legacy of hazardous radioactive waste, which must be isolated from the biosphere for over 100,000 years. The preferred option for safe waste disposal is a deep subsurface geological disposal facility (GDF). Due to the very long geological timescales required, and the complexity of materials to be disposed of (including a wide range of nutrients and electron donors/acceptors) microbial activity will likely play a pivotal role in the safe operation of these mega-facilities. A GDF environment provides many metabolic challenges to microbes that may inhabit the facility, including high temperature, pressure, radiation, alkalinity, and salinity, depending on the specific disposal concept employed. However, as our understanding of the boundaries of life is continuously challenged and expanded by the discovery of novel extremophiles in Earth’s most inhospitable environments, it is becoming clear that microorganisms must be considered in GDF safety cases to ensure accurate predictions of long-term performance. This review explores extremophilic adaptations and how this knowledge can be applied to challenge our current assumptions on microbial activity in GDF environments. We conclude that regardless of concept, a GDF will consist of multiple extremes and it is of high importance to understand the limits of polyextremophiles under realistic environmental conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
29. Reliability of electromyography during 2000 m rowing ergometry.
- Author
-
Gee, Thomas I., Mulloy, Franky, Gibbon, Karl C., Stone, Mark R., and Thompson, Kevin G.
- Subjects
ELECTROMYOGRAPHY ,ERECTOR spinae muscles ,VASTUS medialis ,BICEPS femoris ,ERGOMETRY - Abstract
Purpose: This study aimed to investigate the reliability of surface electromyography (EMG) assessed at seven muscles during three repeated 2000 m rowing ergometer sessions. Methods: Twelve male well-trained rowers participated in a repeated measures design, performing three 2000 m rowing ergometer sessions interspersed by 3–7 days (S1, S2, S3). Surface electrodes were attached to the gastrocnemius, biceps femoris, gluteus maximus, erector spinae, vastus medialis, rectus abdominis and latissimus dorsi for EMG analysis. Results: No differences existed between 2000 m sessions for EMG amplitude for any of the seven muscles (p = 0.146–0.979). Mean coefficient of variation of EMG for 6 of 7 muscles was 'acceptable' (12.3–18.6%), although classed as 'weak' for gastrocnemius (28.6%). Mean intra-class correlation coefficient values across muscles ranged from 'moderate' to 'very large' (0.31–0.89). Within-session EMG activation rates of vastus medialis were greater during 0–500 m and 1500–2000 m segments, compared with 500–1000 m and 1000–1500 m (p < 0.05). Values for biceps femoris and gluteus maximus were significantly higher during 1500–2000 m compared to 500–1000 m and 1000–1500 m (p < 0.05). The general pattern was for higher activation rates during 0–500 m and 1500–2000 m compared to 500–1000 m and 1000–1500 m. However, there were no between-sessions differences in EMG for any of the 500 m segments (p > 0.05). Conclusion: Reliability of EMG values over repeated 2000 m sessions was generally 'acceptable'. However, EMG was seemingly not sensitive enough to detect potential changes in neural activation between-sessions, with respect to changes in pacing strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
30. Pakan Fermentasi Berbasis Bahan Lokal Berbentuk Pellet dan Tepung Terhadap Performa, Karkas dan Organ Intestinal Ayam Broiler.
- Author
-
Manu, Kurnia R., Mulyantini, N. G. A., Kallau, Novalino H. G., Telupere, Franky M. S., and Detha, Annytha I. R.
- Abstract
This study aims to examine the fermentation method on local feed in the form of mash and pellets on the performance, carcass and intestinal organs of broiler chickens. The livestock used were 144 CP 707 broiler chickens aged 21 days. The study used a completely randomized design with a 3x2 factorial pattern, namely 3 fermented feed treatments (F0 = non-fermented, F1 = fermented with Effective Microorganisms-4 (EM4), and F2 = Local Microorganism (MOL) fermented), and 2 forms of feed (B1 = mash, B2 = Pellet), so there were 6 treatment. Each treatment was repeated 6 times and each repetition consisted of 4 chickens. Parameters measured were the performance of broiler chickens, carcasses and intestinal organs. Data were analysed by ANOVA test and continued with Duncan's test. The results showed that feeding fermented Effective Microorganisms-4 (EM4) and Local Microorganism (MOL) had a significant effect on chicken performance and final weight (P<0.01), but no significant effect on carcass weight and percentage (P>0.05). As for the intestinal organs, feeding fermented Effective Microorganisms-4 (EM4) and Local Microorganism (MOL) had no significant effect on the percentage of liver, ventricle, proventriculus and small intestine (P>0.05) and had a significant effect on the length of the small intestine (P<0.01). [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
31. Mass Spectrometric Detection of Formaldehyde-Crosslinked PBMC Proteins in Cell-Free DNA Blood Collection Tubes.
- Author
-
Röth, Daniel, Molina-Franky, Jessica, Williams, John C., and Kalkum, Markus
- Subjects
FORMALDEHYDE ,CELL-free DNA ,ETHYLENEDIAMINETETRAACETIC acid ,MONONUCLEAR leukocytes ,PROTEIN crosslinking ,TUBES ,CYTOSKELETAL proteins - Abstract
Streck tubes are commonly used to collect blood samples to preserve cell-free circulating DNA. They contain imidazolidinyl urea as a formaldehyde-releasing agent to stabilize cells. We investigated whether the released formaldehyde leads to crosslinking of intracellular proteins. Therefore, we employed a shotgun proteomics experiment on human peripheral blood mononuclear cells (PBMCs) that were isolated from blood collected in Streck tubes, EDTA tubes, EDTA tubes containing formaldehyde, or EDTA tubes containing allantoin. The identified crosslinks were validated in parallel reaction monitoring LC/MS experiments. In total, we identified and validated 45 formaldehyde crosslinks in PBMCs from Streck tubes, which were also found in PBMCs from formaldehyde-treated blood, but not in EDTA- or allantoin-treated samples. Most were derived from cytoskeletal proteins and histones, indicating the ability of Streck tubes to fix cells. In addition, we confirm a previous observation that formaldehyde crosslinking of proteins induces a +24 Da mass shift more frequently than a +12 Da shift. The crosslinking capacity of Streck tubes needs to be considered when selecting blood-collection tubes for mass-spectrometry-based proteomics or metabolomic experiments. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
32. Photoelectrochemical behaviour of photoanodes under high photon fluxes.
- Author
-
Holmes-Gentle, Isaac, Bedoya-Lora, Franky E., Aimone, Lorenzo, and Haussener, Sophia
- Abstract
The experimental behaviour of photoelectrochemical materials illuminated under high irradiance conditions >100 kW m
−2 has not been studied despite being potentially advantageous for improving the photoelectrochemical performance and the system-level design through the miniaturisation of PEC cells, and for providing conditions that can mimic accelerated ageing or long term operation. This study presents the design of a high flux photoelectrochemical (HFPEC) test cell, which ensured adequate cooling through forced convention, and experimental setup in a high flux solar simulator for the study of light-dependent behaviour of two reference materials, Sn-doped Fe2 O3 and BiVO4 , under high irradiances (up to 358 kW m−2 ). Current densities of up to 1500 and 300 A m−2 were achieved for FTO‖Fe2 O3 and FTO‖BiVO4 , respectively. To qualitatively deconvolve the different phenomena and their effects, temperature dependence studies under approx. 1 sun (1 sun = 1 kW m−2 ) illumination were performed. It was found that the sublinear light-dependent behaviour was not explained by the temperature increase under illumination and, based on multiphysics modelling, likely primarily arises from bubble-induced losses. Furthermore, whilst the overall degradation rate increases for FTO‖BiVO4 samples under increasing irradiance, a fitted phenomenological model indicates that the degradation kinetics are light-dependent, where increased irradiance diminishes the fraction of charge consumed by photocorrosion reactions. This study highlights the potential of HFPEC experiments to contribute to the scientific analysis of semiconductor–electrolyte behaviour at high photon flux conditions and to identify and resolve the practical challenges of engineering HFPEC devices. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
33. Building capacity for estimating fire emissions from tropical peatlands; a worked example from Indonesia.
- Author
-
Krisnawati, Haruni, Volkova, Liubov, Budiharto, Budiharto, Zamzani, Franky, Adinugroho, Wahyu C., Qirom, Muhammad A., and Weston, Christopher J.
- Subjects
PEATLANDS ,CONSTRUCTION cost estimates ,GREENHOUSE gases ,PEATLAND restoration ,BIOMASS burning - Abstract
Tropical peatlands are globally significant in the terrestrial carbon cycle as they are comprised of a large forest carbon sink and a large peat carbon store—both of which can potentially be exchanged with the atmosphere on decadal time frames. Greenhouse gas emissions from fire-disturbance and development of tropical peatlands over the last few decades, and the potential for ongoing emissions, highlights the need for policy to slow or halt emissions and to activate mechanisms to sequester carbon through restoration of degraded peatlands. The UN REDD + scheme provides a means for developing countries to receive payments for avoided deforestation and forest degradation, but the steps to achieve REDD+ compliance are rigorous and the details required can be a barrier to activating benefits—especially for peatlands where repeated cycles of fire interrupt forest recovery and create a range of recovery classes. Therefore, to improve estimates of peat fire emissions and of carbon balance of tropical peatlands, the biomass and combustion factor parameters need to be developed and applied according to forest recovery stage. In this study we use published activity data from the extensive 1997 fires in the peatlands of Indonesian Borneo to detail a transparent and accountable way to estimate and report emissions from tropical peatland fires. This example for estimating and reporting emissions is provided to assist REDD+ countries to efficiently develop their capacity for improving emissions estimates from fire-impacted tropical peatlands. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
34. Multiple Routes to Color Convergence in a Radiation of Neotropical Poison Frogs.
- Author
-
Twomey, Evan, Melo-Sampaio, Paulo, Schulte, Lisa M, Bossuyt, Franky, Brown, Jason L, and Castroviejo-Fisher, Santiago
- Subjects
DENDROBATIDAE ,CONVERGENT evolution ,STRUCTURAL colors ,HUMAN skin color ,RADIATION ,CAROTENOIDS ,ANIMAL coloration ,HOMOLOGY (Biology) - Abstract
Convergent evolution is defined as the independent evolution of similar phenotypes in different lineages. Its existence underscores the importance of external selection pressures in evolutionary history, revealing how functionally similar adaptations can evolve in response to persistent ecological challenges through a diversity of evolutionary routes. However, many examples of convergence, particularly among closely related species, involve parallel changes in the same genes or developmental pathways, raising the possibility that homology at deeper mechanistic levels is an important facilitator of phenotypic convergence. Using the genus Ranitomeya , a young, color-diverse radiation of Neotropical poison frogs, we set out to 1) provide a phylogenetic framework for this group, 2) leverage this framework to determine if color phenotypes are convergent, and 3) to characterize the underlying coloration mechanisms to test whether color convergence occurred through the same or different physical mechanisms. We generated a phylogeny for Ranitomeya using ultraconserved elements and investigated the physical mechanisms underlying bright coloration, focusing on skin pigments. Using phylogenetic comparative methods, we identified several instances of color convergence, involving several gains and losses of carotenoid and pterin pigments. We also found a compelling example of nonparallel convergence, where, in one lineage, red coloration evolved through the red pterin pigment drosopterin, and in another lineage through red ketocarotenoids. Additionally, in another lineage, "reddish" coloration evolved predominantly through structural color mechanisms. Our study demonstrates that, even within a radiation of closely related species, convergent evolution can occur through both parallel and nonparallel mechanisms, challenging the assumption that similar phenotypes among close relatives evolve through the same mechanisms. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
35. Mapalus and Disaster Risk Reduction: Exploring The Spirit of Mapalus Among Tombulu Community.
- Author
-
Oroh, Hilda Vemy, Lasut, Gisella Liberty, Franky Rampengan, Mercy Maggy, Kumaat, Joyce Christian, and Putri, Anindya Puspita
- Subjects
SOCIAL capital ,FUTURES studies ,EMERGENCY management ,SUSTAINABILITY - Abstract
The perspective of disaster has shifted from that of an inevitable catastrophe to a natural phenomenon in which the impact can be reduced by strengthening existing capacity within the community. Local capacity played an important part in disaster risk reduction. This is especially true in Indonesia where disaster can strike anytime because of its geographic location. Several studies have been done to identify local wisdom related to disaster risk reduction in Indonesia. However, the study of Mapalus local wisdom in Tombulu people in Tomohon, North Sulawesi related to disaster risk reduction is little to non-existent. Therefore, an effort toward linking Mapalus local wisdom and practices in Tombulu community was made in an attempt to fill the gap in the literature. This paper correlates social and economic capital found in existing Mapalus local wisdom and practices with sustainable livelihood perspective for disaster risk reduction. Future research may refer to this paper as a stepping stone toward unraveling the spirit of Mapalus in disaster risk reduction context. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
36. Association of vitamin D receptor gene polymorphisms with breast cancer risk.
- Author
-
Patel, Shruti R., Patel, Kinjal D., Patel, Jayendra B., Patel, Prabhudas S., and Shah, Franky Dhaval
- Subjects
VITAMIN D receptors ,BRCA genes ,DISEASE risk factors ,GENETIC variation ,VITAMIN D ,GENE transfection - Abstract
Background: Recent literature suggests that vitamin D signaling has a protective effect against breast cancer risk. Thus, the aim of the present study was to find the association of vitamin D receptor (VDR) gene polymorphisms with breast cancer risk. Materials and Methods: Fok1, Bsm1, Apa1, and Taq1 polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and Poly A polymorphism was carried out using PCR-SSCP in 140 breast cancer patients and 155 controls. Results: Odds ratio was significantly higher in both homozygous variant genotypes (LL) of Poly A polymorphism of VDR (odds ratio [OR] = 5.42, 95% confidence interval [CI] = 1.19-23.31, P = 0.02) and heterozygous variant genotypes (SL) of Poly A polymorphism of VDR (OR = 3.89, 95% CI = 1.10-13.7, P = 0.03). Fok1, Bsm1, Apa1, and Taq1 polymorphisms of VDR gene were not significantly associated with breast cancer risk. Conclusion: Poly A polymorphism at the 3' untranslated region (UTR) of VDR gene was significantly associated with breast cancer risk in West Indian population. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
37. Relationship between Duffy Genotype/Phenotype and Prevalence of Plasmodium vivax Infection: A Systematic Review.
- Author
-
Picón-Jaimes, Yelson Alejandro, Lozada-Martinez, Ivan David, Orozco-Chinome, Javier Esteban, Molina-Franky, Jessica, Acevedo-Lopez, Domenica, Acevedo-Lopez, Nicole, Bolaño-Romero, Maria Paz, Visconti-Lopez, Fabriccio J., Bonilla-Aldana, D. Katterine, and Rodriguez-Morales, Alfonso J.
- Published
- 2023
- Full Text
- View/download PDF
38. Building capacity for estimating fire emissions from tropical peatlands; a worked example from Indonesia.
- Author
-
Krisnawati, Haruni, Volkova, Liubov, Budiharto, Budiharto, Zamzani, Franky, Adinugroho, Wahyu C., Qirom, Muhammad A., and Weston, Christopher J.
- Subjects
PEATLANDS ,CONSTRUCTION cost estimates ,GREENHOUSE gases ,PEATLAND restoration ,BIOMASS burning - Abstract
Tropical peatlands are globally significant in the terrestrial carbon cycle as they are comprised of a large forest carbon sink and a large peat carbon store—both of which can potentially be exchanged with the atmosphere on decadal time frames. Greenhouse gas emissions from fire-disturbance and development of tropical peatlands over the last few decades, and the potential for ongoing emissions, highlights the need for policy to slow or halt emissions and to activate mechanisms to sequester carbon through restoration of degraded peatlands. The UN REDD + scheme provides a means for developing countries to receive payments for avoided deforestation and forest degradation, but the steps to achieve REDD+ compliance are rigorous and the details required can be a barrier to activating benefits—especially for peatlands where repeated cycles of fire interrupt forest recovery and create a range of recovery classes. Therefore, to improve estimates of peat fire emissions and of carbon balance of tropical peatlands, the biomass and combustion factor parameters need to be developed and applied according to forest recovery stage. In this study we use published activity data from the extensive 1997 fires in the peatlands of Indonesian Borneo to detail a transparent and accountable way to estimate and report emissions from tropical peatland fires. This example for estimating and reporting emissions is provided to assist REDD+ countries to efficiently develop their capacity for improving emissions estimates from fire-impacted tropical peatlands. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
39. The potential role of biofilms in promoting fouling formation in radioactive discharge pipelines.
- Author
-
Barton, Franky, Spencer, Ben F., Tartèse, Romain, Graham, James, Shaw, Samuel, Morris, Katherine, and Lloyd, Jonathan R.
- Subjects
FOULING ,RADIOISOTOPES ,RADIOACTIVE contamination ,BIOFILMS ,NUCLEAR facilities ,WATER pipelines ,POLYELECTROLYTES - Abstract
Nuclear facility discharge pipelines accumulate inorganic and microbial fouling and radioactive contamination, however, research investigating the mechanisms that lead to their accumulation is limited. Using the Sellafield discharge pipeline as a model system, this study utilised modified Robbins devices to investigate the potential interplay between inorganic and biological processes in supporting fouling formation and radionuclide uptake. Initial experiments showed polyelectrolytes (present in pipeline effluents), had minimal effects on fouling formation. Biofilms were, however, found to be the key component promoting fouling, leading to increased uptake of inorganic particulates and metal contaminants (Cs, Sr, Co, Eu and Ru) compared to a non-biofilm control system. Biologically-mediated uptake mechanisms were implicated in Co and Ru accumulation, with a potential bioreduced Ru species identified on the biofilm system. This research emphasised the key role of biofilms in promoting fouling in discharge pipelines, advocating for the use of biocide treatments methods. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
40. Classification of Pneumonia from Chest X-ray Images Using Keras Module TensorFlow.
- Author
-
Satria Arisgraha, Franky Chandra, Rulaningtyas, Riries, and Kusumawardani, Miranti Ayudya
- Subjects
PNEUMONIA diagnosis ,X-rays ,CONVOLUTIONAL neural networks ,INFLAMMATION ,ALVEOLITIS ,RESPIRATORY diseases - Abstract
Pneumonia is a respiratory disease caused by bacteria and viruses that attack the alveoli, causing inflammation of the alveoli. This study aims to examine the ability of the Convolutional Neural Network (CNN) model to classify pneumonia and normal x-ray images. The method used in this research is to construct a CNN model from scratch by compiling layers one by one with the help of the Keras TensorFlow module, which consists of a Convolution layer, MaxPooling layer, Flatten layer, Dropout layer, and Dense layer. Data used in this research is from Guangzhou Women and Children Medical Center, Guangzhou, China. The total data used is 200 images divided into 160 test data, 20 training data, and 20 validation data. From the results of the research conducted, the model has the fastest processing speed of 9.6ms/epoch with a total of 20 epochs. The model has the highest accuracy value of 77% in the training process and an accuracy value of 80% in the testing process. The highest sensitivity value is 1.54 in training and 1.6 in testing. The highest specificity value is 0.77 in training and 0.8 in testing. It can be said that the model can do good classification. Pendahuluan / Introduction (first level heading). [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. Knowledge, attitudes and experience of physicians working in Chile toward the prescription of pre-exposure prophylaxis (PrEP): A cross-national survey.
- Author
-
Orozco-Chinome, Javier E, Picón-Jaimes, Yelson A, Lozada-Martinez, Ivan D, Molina-Franky, Jessica, Bolaño Romero, Maria P, and Acevedo-López, Doménica
- Published
- 2023
- Full Text
- View/download PDF
42. Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation.
- Author
-
Sentosa, Jason, Djutanta, Franky, Horne, Brian, Showkeir, Dominic, Rezvani, Robert, Leff, Chloe, Pradhan, Swechchha, and Hariadi, Rizal F.
- Subjects
DNA folding ,DNA nanotechnology ,RESOURCE-limited settings ,CENTRIFUGATION ,ROTATIONAL motion ,CHEMICAL purification ,DNA microarrays - Abstract
DNA origami purification is essential for many fields, including biophysics, molecular engineering, and therapeutics. The increasing interest in DNA origami has led to the development of rate-zonal centrifugation (RZC) as a scalable, high yield, and contamination-free method for purifying DNA origami nanostructures. RZC purification uses a linear density gradient of viscous media, such as glycerol or sucrose, to separate molecules according to their mass and shape. However, many methods for creating density gradients are time-consuming because they rely on slow passive diffusion. To expedite the preparation time, we used a LEGO gradient mixer to generate rotational motion and rapidly create a quasi-continuous density gradient with a minimal layering of the viscous media. Rotating two layers of differing concentrations at an angle decreases the time needed to form the density gradient from a few hours to minutes. In this study, the density gradients created by the LEGO gradient mixer were used to purify 3 DNA origami shapes that have different aspect ratios and numbers of components, with an aspect ratio ranging from 1:1 to 1:100 and the number of components up to 2. The gradient created by our LEGO gradient mixer is sufficient to purify folded DNA origami nanostructures from excess staple strands, regardless of their aspect ratios. Moreover, the gradient was able to separate DNA origami dimers from DNA origami monomers. In light of recent advances in large-scale DNA origami production, our method provides an alternative for purifying DNA origami nanostructures in large (gram) quantities in resource-limited settings. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Design of greenhouse monitoring for hydroponic based on microcontroller and android system.
- Author
-
Firdaus, Aji Akbar, Arisgraha, Franky Chandra Satria, Oktamaulana, Irgi, Subekti, Thomi Tri, Anggriawan, Dimas Okky, Ali, Machrus, and Putra, Dimas Fajar Uman
- Subjects
MICROCONTROLLERS ,FOOD security ,HUMIDITY control ,GREENHOUSES ,ECONOMIC development ,FARMS - Abstract
Food crisis can hamper economic growth and progress of a nation. According to the World Food Program data in 2017 stated that 87 million Indonesians are still vulnerable to food security. In addition, agricultural land in urban and rural areas is increasingly narrow so that the food crisis cannot be prevented. Therefore, making greenhouse is used to increase food productivity in Indonesia. This greenhouse is equipped with temperature, humidity and light controls as well as a roof that can be opened and closed so that the condition of the greenhouse can be set as desired. And conditions in this greenhouse are also monitored using the Android application. From the test results, greenhouse monitoring based on microcontroller and android system can work in accordance with the desired program instructions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. An association of epidermal growth factor receptor mutation subtypes with prognostic prediction and site-specific recurrence in advanced stage lung cancer patients.
- Author
-
Joshi, Jigna, Pandit, Apexa, Tarapara, Bhoomi, Patel, Hitarth, Bhavnagari, Hunayna, Panchal, Harsha, and Shah, Franky D.
- Abstract
Background: Concerning the different clinical behavior of epidermal growth factor receptor (EGFR) subtypes in advanced-stage lung cancer patients, the current study aimed to evaluate the clinical, pathological, and prognostic significance of EGFR mutation subtypes, and treatment response in patients with advanced-stage lung cancer. Methods and results: A retrospective study enrolled a total of 346 patients with advanced-stage lung cancer tested for EGFR mutation. EGFR mutation was analyzed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Statistical analysis was performed using SPSS version 20.0. EGFR mutation was evident in 38% of patients with the highest prevalence of exon 19 deletions. A higher incidence of 19-deletions and 20-insertions were observed in young patients, while a higher incidence of L858R was noted in old age patients. Patients with de-novo T790M failed to improve their OS by any of the treatment modalities. Patients with de-novo T790M mutation have a higher risk of developing lung, liver, and multiple site metastases while patients with L858R mutation have a higher risk of developing brain metastasis. Additionally, patients with 19 deletion mutation did not improve their OS after receiving conventional chemotherapy hence, they demonstrate better survival only after EGFR-TKIs. Multivariate survival analysis predicted chemotherapy as an independent predictor of OS. Conclusion: Besides clinicopathological and prognostic consequences of EGFR mutation and mutation subtypes, patients harboring TKI sensitive, or insensitive mutations reveal different secondary disease development and hence should be treated accordingly for better survival. Current findings may provide the basis for a better treatment strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. Miniaturized Compact Reconfigurable Half-Mode SIW Phase Shifter with PIN Diodes.
- Author
-
Wappi, Franky Dakam, Mnasri, Bilel, Ghayekhloo, Alireza, Talbi, Larbi, and Boutayeb, Halim
- Subjects
PIN diodes ,PHASE shifters ,ELECTRONIC equipment ,PRINTED circuits ,INSERTION loss (Telecommunication) ,ELECTRIC lines ,INTEGRATED optics - Abstract
In this work, a novel electrically reconfigurable phase shifter based on a half-mode substrate integrated waveguide (HM-SIW) is proposed. SIW is a guided transmission line topology, and by using half-mode excitation, a smaller size can be achieved. Phase shifters are electronic devices that change the phase of transmission for a wide range of applications, including inverse scattering and sensing. The tunability of PIN diodes is applied here to achieve a reconfigurable design. The proposed single-layer structure does not require extra wiring layers for the bias circuit on the suggested printed circuit board. Its principle consists in the integration, in the HM-SIW, of three parallel lines, each connecting the edge of the HM-SIW and linked to a PIN diode and a radial stub. Here we present the results of measurements for a frequency band from 4.5 to 7 GHz that demonstrate how the experiment agrees with simulations. Insertion loss was less than −10 dB, and port coupling was less than −2 dB for both simulation and measurement solutions. The proposed half-mode structure is around half the size of a typical SIW line. With the proposed design, the seven states of the PIN diodes can be validated (ON and OFF), with a wide band adaptation and a relatively constant phase difference across a broad frequency range (44%). A key benefit of the proposed design for a microwave component is the reduction of extra biasing layers for the PIN diodes. This is in addition to the reduced size of the transmission line compared to a commercial SIW. In the annexed section, simulation software is used for a more comprehensive analysis involving more phase shift values and parametric studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
46. Decoding the hydrodynamic properties of microscale helical propellers from Brownian fluctuations.
- Author
-
Djutanta, Franky, Brown, Peter T., Nainggolan, Bonfilio, Coullomb, Alexis, Radhakrishnan, Sritharini, Sentosa, Jason, Yurke, Bernard, Hariadi, Rizal F., and Shepherd, Douglas P.
- Subjects
PROPELLERS ,MOTILITY of bacteria ,FLUCTUATION-dissipation relationships (Physics) ,COLLECTIVE behavior ,FLUID control - Abstract
The complex motility of bacteria, ranging from single-swimmer behaviors such as chemotaxis to collective dynamics, including biofilm formation and active matter phenomena, is driven by their microscale propellers. Despite extensive study of swimming flagellated bacteria, the hydrodynamic properties of their helical-shaped propellers have never been directly measured. The primary challenges to directly studying microscale propellers are 1) their small size and fast, correlated motion, 2) the necessity of controlling fluid flow at the microscale, and 3) isolating the influence of a single propeller from a propeller bundle. To solve the outstanding problem of characterizing the hydrodynamic properties of these propellers, we adopt a dual statistical viewpoint that connects to the hydrodynamics through the fluctuation-dissipation theorem (FDT). We regard the propellers as colloidal particles and characterize their Brownian fluctuations, described by 21 diffusion coefficients for translation, rotation, and correlated translation-rotation in a static fluid. To perform this measurement, we applied recent advances in high-resolution oblique plane microscopy to generate high-speed volumetric movies of fluorophore-labeled, freely diffusing Escherichia coli flagella. Analyzing these movies with a bespoke helical single-particle tracking algorithm, we extracted trajectories, calculated the full set of diffusion coefficients, and inferred the average propulsion matrix using a generalized Einstein relation. Our results provide a direct measurement of a microhelix's propulsion matrix and validate proposals that the flagella are highly inefficient propellers, with a maximum propulsion efficiency of less than 3%. Our approach opens broad avenues for studying the motility of particles in complex environments where direct hydrodynamic approaches are not feasible. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. KAJIAN YURIDIS PERTANGGUNGJAWABAN PIDANA PELAKSANAAN KONTRAK KERJA KONSTRUKSI JALAN YANG BERIMPLIKASI PADA TINDAK PIDANA KORUPSI.
- Author
-
Simamora, Franky, Sinurat, Aksi, and Manuain, Orpa G.
- Abstract
Copyright of Jurnal Indonesia Sosial Teknologi is the property of Publikasi Indonesia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
48. In-hospital antibiotic use for severe chronic obstructive pulmonary disease exacerbations: a retrospective observational study.
- Author
-
Vanoverschelde, Anna, Van Hoey, Chloë, Buyle, Franky, Den Blauwen, Nadia, Depuydt, Pieter, Van Braeckel, Eva, and Lahousse, Lies
- Subjects
CHRONIC obstructive pulmonary disease ,DISEASE exacerbation ,LENGTH of stay in hospitals ,COMORBIDITY ,ANTIBIOTICS - Abstract
Background: The use of antibiotics in mild to severe acute exacerbations of chronic obstructive pulmonary disease (COPD) remains controversial. Aim: To explore in-hospital antibiotic use in severe acute exacerbations of COPD (AECOPD), to analyze determinants of in-hospital antibiotic use, and to investigate its association with hospital length of stay (LOS) and in-hospital mortality. Methods: A retrospective, observational study was conducted in Ghent University Hospital. Severe AECOPD were defined as hospitalizations for AECOPD (ICD-10 J44.0 and J44.1) discharged between 2016 and 2021. Patients with a concomitant diagnosis of pneumonia or 'pure' asthma were excluded. An alluvial plot was used to describe antibiotic treatment patterns. Logistic regression analyses identified determinants of in-hospital antibiotic use. Cox proportional hazards regression analyses were used to compare time to discharge alive and time to in-hospital death between antibiotic-treated and non-antibiotic-treated AECOPD patients. Results: In total, 431 AECOPD patients (mean age 70 years, 63% males) were included. More than two-thirds (68%) of patients were treated with antibiotics, mainly amoxicillin-clavulanic acid. In multivariable analysis, several patient-related variables (age, body mass index (BMI), cancer), treatment-related variables (maintenance azithromycin, theophylline), clinical variables (sputum volume and body temperature) and laboratory results (C-reactive protein (CRP) levels) were associated with in-hospital antibiotic use independent of sputum purulence, neutrophil counts, inhaled corticosteroids and intensive care unit of which CRP level was the strongest determinant. The median hospital LOS was significantly longer in antibiotic-treated patients (6 days [4–10]) compared to non-antibiotic-treated patients (4 days [2–7]) (p < 0.001, Log rank test). This was indicated by a reduced probability of hospital discharge even after adjustment for age, sputum purulence, BMI, in-hospital systemic corticosteroid use and forced expiratory volume in one second (FEV
1 ) (adjusted hazard ratio 0.60; 95% CI 0.43; 0.84). In-hospital antibiotic use was not significantly associated with in-hospital mortality. Conclusions: In this observational study in a Belgian tertiary hospital, in-hospital antibiotic use among patients with severe AECOPD was determined by the symptom severity of the exacerbation and the underlying COPD severity as recommended by the guidelines, but also by patient-related variables. Moreover, in-hospital antibiotic use was associated with a longer hospital stay, which may be linked to their disease severity, slower response to treatment or 'harm' due to antibiotics. Trial registration: Number: B670201939030; date of registration: March 5, 2019. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
49. A survey for variable young stars with small telescopes: VI – Analysis of the outbursting Be stars NSW 284, gaia 19eyy, and VES 263.
- Author
-
Froebrich, Dirk, Hillenbrand, Lynne A, Herbert, Carys, De, Kishalay, Eislöffel, Jochen, Campbell-White, Justyn, Kahar, Ruhee, Hambsch, Franz-Josef, Urtly, Thomas, Popowicz, Adam, Bernacki, Krzysztof, Malcher, Andrzej, Lasota, Slawomir, Fiolka, Jerzy, Jozwik-Wabik, Piotr, Dubois, Franky, Logie, Ludwig, Rau, Steve, Phillips, Mark, and Fleming, George
- Subjects
VARIABLE stars ,CIRCUMSTELLAR matter ,TELESCOPES ,LIGHT curves ,PHOTOMETRY - Abstract
This paper is one in a series reporting results from small telescope observations of variable young stars. Here, we study the repeating outbursts of three likely Be stars based on long-term optical, near-infrared, and mid-infrared photometry for all three objects, along with follow-up spectra for two of the three. The sources are characterized as rare, truly regularly outbursting Be stars. We interpret the photometric data within a framework for modelling light-curve morphology, and find that the models correctly predict the burst shapes, including their larger amplitudes and later peaks towards longer wavelengths. We are thus able to infer the start and end times of mass loading into the circumstellar discs of these stars. The disc sizes are typically 3 – 6 times the areas of the central star. The disc temperatures are ∼40 per cent, and the disc luminosities are ∼10 per cent of those of the central Be star, respectively. The available spectroscopy is consistent with inside-out evolution of the disc. Higher excitation lines have larger velocity widths in their double-horned shaped emission profiles. Our observations and analysis support the decretion disc model for outbursting Be stars. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. An in-silico analysis to identify structural, functional and regulatory role of SNPs in hMRE11.
- Author
-
Tarapara, Bhoomi and Shah, Franky
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.