Search

This study examined a 6-week intervention in which fourth grade students either played fluency games or used pictorial flashcards to develop fluency with their basic multiplication facts. Students who played fluency games showed more growth than the pictorial flashcards, but an analysis of variance showed that there was no statistically significant difference between the two groups. Additionally, pre- and post-intervention interviews indicated changes in students' use of strategies when given basic fact multiplication problems. In the post-intervention interviews students used fewer earlier strategies (direct modeling, repeated addition, and skip counting). Specifically, students who used fluency games used more derived fact strategies along with direct recall, and students who used pictorial flashcards moved toward direct recall strategies with fewer derived fact strategies. The article concludes with implications for future development of students' basic fact multiplication fluency. [ABSTRACT FROM AUTHOR]

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine. The authors outline a framework uniting electronic medical records with post-genomic data to capture real-time physiological changes via periodic molecular snapshots, enabling a shift from reactive treatments to proactive, inclusive care. [ABSTRACT FROM AUTHOR]

Background: Palliative care aims to ensure a dignified and self-determined life for people facing the end of life. While palliative care is established for tumor diseases, it's notably absent from German medical guidelines for other progressive diseases with an unfavorable prognosis such as dementia. This study will identify predictors of palliative care use in older patients and explore how these predictors relate to the probability of palliative care. Methods: We used data from the largest German health insurance company of people over 50 years of age from the period 2014–2019. The analysis focused on the last year of life. Outcomes were outpatient and inpatient palliative care and predictors were demographics, comorbidities, therapeutic remedies and rehabilitation, care and medical interventions, medication and patient group. Combined logistic regression models and discrete conditional inference survival forests were used to predict the utilization of outpatient and inpatient palliative care. For evaluation we used concordance-index and calibration plots. We identified the most important predictors by using a permutation approach and the log-loss metric. Results: The study cohort for the analysis of inpatient palliative care comprised 43,896 patients, while the cohort for the analysis of outpatient palliative care included a total of 37,430 patients. The models had appropriate discriminatory power (inpatient palliative care: concordance-index = 0.737 (95%CI = 0.721–0.754); outpatient palliative care: concordance-index = 0.689; 95%CI = 0.675–0.704) and showed appropriate calibration. A diagnosis of dementia, like a diagnosis of cancer, is predictive of inpatient palliative care and outpatient palliative care. We observed a lower probability for inpatient and for outpatient palliative care for dementia patients compared to cancer patients. Conclusions: The findings highlight the need to focus palliative care on other patient groups besides cancer patients, such as dementia patients, and to facilitate access for all patients. [ABSTRACT FROM AUTHOR]

In liver allocation systems based on the Model for End-stage Liver Disease (MELD) score, sex inequities have been identified in countries with high organ donation rates. Whether similar inequities exist in regions with average to low donation rates remained unclear. We assessed the impact of sex on transplantation rates, waiting list mortality and post-transplant survival in 25,943 patients waitlisted for liver transplantation in Germany between 2003 and 2017 using competing risk analysis. Women are currently underrepresented on the waiting list (33.3%) and among transplant recipients (31.1%) compared to their proportion of severe liver disease cases (35.1%). The introduction of MELD-based allocation has worsened this disadvantage [HR before: 0.89 (0.81–0.98), after: 0.77 (0.74–0.81)]. Three key factors contribute to this disparity: Women have lower creatinine levels despite worse renal function, reducing their MELD score (median 1, 0–3). Second, exceptional MELD points are more frequently granted to men [HR 1.61 (1.54–1.69) compared to regular allocation]. Third, the small height of women has the highest impact on the probability of not being transplanted [adjusted HR 0.85 (0.81–0.9)]. Even in countries with lower organ donation rates, MELD-based allocation leads to sex inequity. Measures are needed to ensure sex-neutral liver allocation in MELD-based systems worldwide. [ABSTRACT FROM AUTHOR]

Background: A significant number of individuals who have contracted SARS-CoV-2 report persistent somatic symptoms after the infection has resolved. Evidence-based treatment options for Long COVID are lacking to date. To ensure that an expectation management intervention, designed for the research project SOMA.COV, addresses relevant patient needs as well as to promote treatment acceptance and adherence, a participatory approach was chosen. Objective: The aim of the present study was to explore needs and wishes of patients with Long COVID regarding the preliminary version of an expectation management intervention and to thereby inform the further development of the treatment manual. Methods: Twenty-two patients affected by Long COVID participated in one of four focus groups in June and July 2023. Participants were presented with the draft content of a four-session expectation management intervention. Feedback was audio-recorded, transcribed, and analyzed using thematic analysis. Results: Thirteen themes relating to the main components of the intervention manual were developed. Large parts of the manual received overall positive feedback, including psychoeducation on the biopsychosocial etiology of the condition, elements of cognitive restructuring, and an imagination exercise. Patients' response to the presented vicious circle of fear and a behavior change exercise was mixed. Modifications to the manual were made in response to patients' feedback. Conclusion: Patients with Long COVID provided positive feedback on an expectation management intervention while also highlighting important adaptations necessary for this patient group. The study results informed the finalization of the treatment manual within the SOMA.COV project, which investigates the effectiveness of this intervention for patients with Long COVID in a three-armed randomized controlled trial. [ABSTRACT FROM AUTHOR]

In savannas, fire triggers physical and chemical changes in the soil, releasing nutrients and other substances predicted to stimulate seed germination and plant growth. However, these effects and how changes along the soil profile can shape species regeneration niches after fire disturbances are still poorly understood. Here, we aimed to investigate (i) whether soil affected by fire alters grass emergence percentage, mean emergence time (MET), number of tillers, and shoot and root dry mass and (ii) how persistent these effects can be over time. We compared seedling emergence and plant growth of three native grasses in soil from Cerrado savannas soon after fire, 6 months after fire and unburned (long time since fire), at two depths (0–2 and 0–10 cm). No differences were found in emergence percentage, but MET was reduced by 42% in the soon after fire soil up to 2 cm, compared to unburned soils at 2 cm. MET was also reduced compared to unburned soils in 0–10 cm 6 months post-fire soil (from 7.5 to 6.4 days). Plants grew more in burned soils than those unburned, displaying greater above and belowground dry mass and more tillers. The effects of fire on plant growth in soils were transient, as plant growth responses in soils after 6 months post-fire were not significantly different from plant growth responses in the unburned soil, except for one species. Here, we add evidence that fire is an essential component in community assembly in savannas, specifically elucidating that it plays an important role in grass regeneration. [ABSTRACT FROM AUTHOR]

Copyright of Die Orthopädie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Mendelian Phenotype Search Engine (MPSE), a clinical decision support tool using Natural Language Processing and Machine Learning, helped neonatologists expedite decisions to whole genome sequencing (WGS) to diagnose patients in the neonatal intensive care unit. After the MPSE was introduced, utilization of WGS increased, time to ordering WGS decreased, and WGS diagnostic yield increased. [ABSTRACT FROM AUTHOR]

Background: Cryoballoon ablation is a widely used single-shot technique for pulmonary vein isolation (PVI) in the treatment of paroxysmal atrial fibrillation (AF). Procedural endpoints ensuring maximal PVI durability are important. Objective: To assess the performance of cryoablation procedural markers to predict long-term PVI. Methods: In a single center, consecutive patients who underwent redo ablation with high-density mapping for symptomatic AF recurrence after cryoballoon ablation were included and cryoballoon procedural data were collected, including temperature values at 30 and 60 s, time to isolation, nadir temperature and the velocity of temperature decline estimated with the temperature/time catch-up point (T2T-Catch-Up) defined as positive when the freeze temperature in minus degree equals the time in seconds after cryoablation initiation (e.g. − 15 °C in the first 15 s of the ablation impulse). Results: 47 patients (62% male; 58.3 ± 11.2 years) were included. Overall, 38 (80.9%) patients had ≥ 1 reconnected PV. Among 186 PVs, 56 (30.1%; 1.2 per patient on average) were reconnected. Univariate analysis revealed T2T-Catch-Up in 103 (56%) and more frequent in durably isolated than in reconnected PVs (93 [72%] vs 10 [19%], p < 0.0001). Among binary endpoints, T2T-Catch-Up had the highest specificity (82%) and predictive value for durable PVI at redo ablation (90%). In multivariable analyses, absence of T2T-Catch-Up (Odds-ratio 0.12, 95% CI [0.05–0.31], p < 0.0001) and right superior PV (Odds-ratio 3.14, 95% CI [1.27–7.74], p = 0.01) were the only variables independently associated with PV reconnection. Conclusion: T2T-Catch-Up, a new and simple cryoballoon procedural endpoint demonstrated excellent predictive value and strong statistical association with durable PVI. [ABSTRACT FROM AUTHOR]

The ability of the European community to respond to the multiple crises threatening the European Union and Europe depends in part on citizens' shared European identity giving legitimacy and support to communal action. Men's elite European club football is an example of a cultural practice that is highly Europeanised, reaches diverse audiences and is a known carrier of collective identities. This article examines the emergence of a European public football sphere through the convergence of football coverage across national media spaces, serving as a foundation for European identity constructions. It connects the concept of a European public sphere to the Europeanisation and mediatisation of football and its potential effects on European identity formation. Results indicate a convergence of football coverage around high‐profile and high‐status aspects of European football, creating a strongly aligned, homogenous but exclusive European public football sphere that leaves many parts of Europe on the sidelines. [ABSTRACT FROM AUTHOR]

Background: Estimating changes in fine fuel loads (FFL) is essential for carbon monitoring and fire management. Field measurements of post-fire fuel response are challenging, leading to reliance on generalised fuel types in operational models. Aims: This study presents a proof-of-concept for estimating fine fuel consumption and accumulation by integrating forest inventory and fire records, aiming to refine fuel dynamics estimates and enhance current practices. Methods: We estimated FFL changes across vertical strata in southeast Australian eucalypt forests, considering burn severity, fire type and forest cover. Fuel consumption was estimated by correlating pre-fire observations with combustion factors defined by burn severity. Fuel accumulation was predicted using modified Olson models with dynamic input parameters. Key results: Wildfires typically occurred in forests with higher FFL and consumed more fuels than prescribed burns. Closed forests experienced greater fuel loss compared with open and woodland forests. Increasing fire severity led to lower decomposition rates and a longer time to reach pre-fire FFL, with denser forests showing higher accumulation rates. Conclusions: Integrating forest inventory and fire history data offers valuable insights into fuel dynamics, potentially enhancing existing fuel hazard models. Implications: The approach is applicable in regions with mature forest inventories and advanced fire severity mapping. This study presents a proof-of-concept for estimating fine fuel consumption and accumulation by integrating forest inventory and fire records, aiming to refine fuel dynamics estimates and enhance current practices. We estimated FFL changes across different vertical strata in southeast Australian eucalypt forests, considering burn severity, fire type and forest cover. [ABSTRACT FROM AUTHOR]

Background: It is unknown if there are differential industry payments to surgeons based on gender. This study aims to examine differences by gender for industry relations with minimally invasive surgeons, using speakers at the SAGES Annual Meeting as a proxy for key thought leaders in minimally invasive surgery. Methods: We queried the Open Payments Database for payments made to US speakers from the 2023 SAGES meeting. All payments from the prior fiscal year prior were collected. The National Provider Identity (NPI) Registry was cross-referenced to determine surgeon's self-reported gender. Industry sponsors were analyzed based on differences in payments made. Results: A total of 305 speakers were assessed, with 175 (57.4%) males and 130 (42.6%) females. Of the 305 speakers, 246 were listed in the OPD. There were 145/175 (82.8%) males who were received general payments, compared to 101/130 (77.6%) females (p = 0.326). The total amount of industry payments was $2,894,287 for males and $1,539,481 for females. Median payments were 2.8X higher for males ($4657, IQR $422-$15,798) than females ($1651, IQR $299-$9005) (p = 0.05). Conclusions: Despite efforts to decrease gender bias in surgery, there remains a significant and substantial difference in payments towards male and female surgeons via industry relationships. This has potential downstream effects on career development, consulting and research opportunities, and development of new devices. [ABSTRACT FROM AUTHOR]

The digital number of a given pixel in a satellite image does not only measure the radiance originating from the area of the Earth's surface represented by this pixel, but also measures radiance originating from surrounding areas represented by adjacent pixels. This adjacency effect, also known as image blurring, is a fundamental limitation of satellite images, and introduces errors in all image processing techniques that quantify the properties of the Earth's surface on a per-pixel basis. Image deblurring via deconvolution, is a traditional technique to reduce the adjacency effect, which has proven effective in a variety of remote sensing applications. For example, it has provided an almost fourfold reduction of the adjacency error, when using support vector machine classifiers to estimate land cover proportion at a subpixel level. The remote sensing literature usually assumes that satellite images should be deconvolved with a kernel defined by the sensor's Point Spread Function PSF(x, y), overlooking the results of three seminal empirical studies which systematically demonstrated that the optimum deconvolution kernel is a shrunk PSF of the form PSF(x/β, y/β), where β < 1 is the optimum shrink factor. The current empirical procedure to find the optimum shrink factor is laborious and restrictive since it requires suitable satellite images of much higher resolution, such that their Ground Sampling Distance (GSD) is equal to the GSD of the sensor of interest divided by an integer number much greater than one. A new theoretical procedure that uses synthetic edge images to find the optimum shrink factor is proposed and applied to the same cases considered by the current empirical procedure, showing that the same results are obtained. The new procedure is much simpler to apply and more accurate and versatile, opening a variety of research paths on satellite image deblurring. [ABSTRACT FROM AUTHOR]

In times of 'polycrisis', numerous challenges threaten unity and cohesion on the European continent. European identities can play an important part in navigating these challenges and fostering solidarity. One key to understanding European identities is analysing the dynamics of inclusion and exclusion, as constructions of belonging form an essential component of individual and collective identities. Football fandom, a popular and highly Europeanised cultural phenomenon, has the potential to shape constructions of belonging to Europe. Given the diverse participation in European football, we posit that the identities of football fans are more inclusive than those of non-fans. Our analysis indicates that football fans are more likely to count countries outside of what is commonly associated with Europe as European. This points to a distinct effect of cultural integration through football and underscores the role football plays in fostering a sense of unity and shared identity across the continent. The findings highlight the importance of leveraging cultural avenues to strengthen European cohesion and unity in times of uncertainty. [ABSTRACT FROM AUTHOR]

A continuous-time multi-state history is semi-Markovian, if an intensity to migrate from one state into a second, depends on the duration in the first state. Such duration can be formalised as marker, entering the intensity process of the transition counts. We derive the intensity process, prove its predictability and the martingale property of the residual to the integrated intensity. In particular, we verify the usual conditions for the respective filtration. As a consequence, according to Nielsen and Linton (1995), a kernel estimator of the transition intensity, including the duration dependence, converges point-wise at a slow rate, compared to the fast rate of the Markovian kernel estimator, i.e. when ignoring duration dependence. By using the inequality of the two rates, we follow Gozalo (1993) and show that the (properly penalised) maximal difference of the two kernel estimators on a random grid of points is asymptotically $ \chi ^2_1 $ χ 1 2 -distributed. As compared to the $ \chi ^2 $ χ 2 goodness-of-fit test on a fixed grid, with less power, the estimator of the variance needs to be shown to converge uniformly. The data example is a sample of 130,000 German women, observed over a period of 10 years, and we model the intensity to die with dementia, potentially dependent on the disease duration. As usual, the models under the null and the alternative hypothesis need to be enlarged to allow for independent right-censoring. We find a significant effect of dementia duration, nearly independent of the bandwidth. A Monte Carlo simulation confirms level and high power of the test with the penalised maximal difference, under the conditions of our application. It also reminds that hyperparameter selection is sensitive to the application. [ABSTRACT FROM AUTHOR]

This article covers the in-vessel design of the SPARC interferometry diagnostic system, highlighting unique aspects of the systems design and port plug integration in preparation for "day-1" plasma operations as a critical diagnostic for density feedback control. An early decision for the diagnostic was to deploy two lasers in the infrared wavelength spectrum, allowing the system to have a higher optical throughput. The optimization of the in-vessel geometry for the diagnostic follows a similar approach, focusing on de-risking possible damage to the plasma facing optical components by moving them further from the plasma with an orientation that provides a greater possibility for protective features to be added. The inclusion of in-vessel optical assemblies requires detailed design efforts of custom all-metal parts, designed to remain functional when subjected to harsh operational conditions, in many cases for the entire SPARC lifetime. The details presented here were included in the design to ensure that the assemblies can not only withstand a major electromagnetic disruption or thermal event but also maintain good stability through normal operations. The design also addresses more nuanced effects, such as the transient heat loading of the plasma facing mirrors. Through the utilization of modeling and design tools, these effects were brought into the design and simulation workflow, further reducing uncertainty as the system moves toward system commissioning. [ABSTRACT FROM AUTHOR]

The intentional and sustained actions to advance diversity, equity, and inclusion (DEI) in school psychology science and scholarship, will have reciprocal and dynamic influences on graduate preparation and practice. Herein, the School Psychology Review leadership team provides reflections on several of our intentional efforts, to date, to advocate for and advance DEI in school psychology scholarship, and the associated implications for graduate preparation and practice. Contemporary actions of the School Psychology Review leadership team have included; (a) establishing commitments to advocating for and advancing DEI as the foundation of our scholarship; (b) diversifying journal leadership and editorial board members to reflect the diverse student body school psychologists serve; (c) preparing future diverse journal leadership through mentored editorial fellowship programs, and a student editorial board with members from diverse backgrounds; (d) featuring special topics relevant to further understanding and supporting diverse and minoritized children, youth, families, and school communities; (e) providing professional-development opportunities and resources; (f) implementation of Open Science opportunities in the journal, (g) implementing triple anonymous peer review to reduce bias, and (h) implementing a journal action plan focused on advancing DEI. Collectively these efforts are aimed to influence positive change in advancing and sustaining DEI efforts in school psychology science, scholarship, graduate preparation and practice. [ABSTRACT FROM AUTHOR]

Introduction: Open reduction and fixation are the standard of care for treating mandibular fractures and usually lead to successful healing. However, complications such as delayed healing, non-union, and infection can compromise patient outcomes and increase healthcare costs. The initial inflammatory response, particularly the response involving specific CD8+ T cell subpopulations, is thought to play a critical role in healing long bone fractures. In this study, we investigated the role of these immune cell profiles in patients with impaired healing of mandibular fractures. Materials and methods: In this prospective study, we included patients with mandibular fractures surgically treated at Charité – Universitätsmedizin Berlin, Germany, between September 2020 and December 2022. We used follow-up imaging and clinical assessment to evaluate bone healing. In addition, we analyzed immune cell profiles using flow cytometry and quantified cytokine levels using electrochemiluminescence-based multiplex immunoassays in preoperative blood samples. Results: Out of the 55 patients enrolled, 38 met the inclusion criteria (30 men and 8 women; mean age 32.18 years). Radiographic evaluation revealed 31 cases of normal healing and 7 cases of incomplete consolidation, including 1 case of non-union. Patients with impaired healing exhibited increased levels of terminally differentiated effector memory CD8+ T cells (TEMRA) and a higher TEMRA to regulatory T cell (Treg) ratio, compared with those with normal healing. Conclusions: Our analysis of mandibular fracture cases confirms our initial hypothesis derived from long bone fracture healing: monitoring the TEMRA to Treg ratio in preoperative blood can be an early indicator of patients at risk of impaired bone healing. Radiologic follow-up enabled us to detect healing complications that might not be detected by clinical assessment only. This study highlights the potential of individual immune profiles to predict successful healing and may form the basis for future strategies to manage healing complications. [ABSTRACT FROM AUTHOR]

This article uses digitised apprenticeship bindings from the Records of London's Livery Companies Online (ROLLCO) to investigate the migration patterns of those moving from Wales to enrol in 10 of the London guilds in the period 1600–1800. Engaging with existing historiography on metropolitan apprenticeship and migration from the English regions to London, this article outlines the sorts of people who travelled from Wales to join the livery companies as well as analysing their motives in terms of push and pull factors. It also compares Welsh migration with the smaller numbers of Irish and Scots who enrolled. Evidence from ROLLCO demonstrates that Welsh migrants moved to London in significant numbers during the early seventeenth century using similar migration routes to many of their English counterparts, but that livery companies did little to integrate Ireland and Scotland into a wider British economy. [ABSTRACT FROM AUTHOR]

Introduction: A frequent complication after TAVI are postinterventional conduction abnormalities requiring permanent pacemaker implantation. In this study, we analyzed the characteristics of borderline conduction abnormalities leading to pacemaker implantation and the resulting ventricular pacing amounts. Methods and Results: All patients who underwent balloon‐expandable TAVI between 2014 and 2019 in our tertiary center were analyzed in a retrospective manner. One hundred and sixty‐five patients of 1083 TAVI‐patients developed postinterventional conduction abnormalities leading to pacemaker implantation. Of these 19 (11.5%) did not represent a clear indication for cardiac pacing according to current European guidelines. Patient characteristics, underlying conduction abnormalities, and the temporal change of ventricular pacing percentages at 24 h and 6 weeks after pacemaker implantation were analyzed. The dominating borderline conduction abnormalities leading to pacemaker implantation were new‐onset persisting bundle‐branch‐blocks and new first‐degree AV‐blocks with progression of AV‐delay. While pacemaker implantation was safe and without severe complications in all cases, only 6 of 19 patients had high pacing amounts (95%−100%) after 24 h while 11 patients had low to no pacing amounts (0%−5%). After 6 weeks, 8 patients showed decreasing pacing amounts, no patient had an increasing amount of ventricular pacing and all patients had an intrinsic ventricular rhythm > 30/min. Conclusion: In our cohort of 1038 TAVI patients, 19 patients underwent PMI for borderline CAs (11.5% of all PMI). Of these, only 2 patients had high pacing amounts after 6 weeks. The risk of complete persisting heart block in these patients is very low. Furthermore, algorithms to reduce ventricular pacing are highly effective to avoid ventricular pacing whenever reasonable. [ABSTRACT FROM AUTHOR]

The design of a compact 2 × 2 diamond matrix with independent and redundant pixels optimized for the spectrometric neutron camera of the SPARC tokamak is presented in this article. Such a matrix overcomes the constraints in dynamic range posed by the size of a single diamond sensor while keeping the ability to perform energy spectral analysis, marking a significant advancement in tokamak neutron diagnostics. A charge pre-amplifier based on radio frequency amplifiers based on InGaP technology transistors, offering up to 2 GHz bandwidth with high robustness against radiation, has been developed. A first single-channel device has been tested and proven to provide a fast signal development time of 20–25 ns, necessary to mitigate pileup effects while offering precise energy measurements. As the diamond sensors may suffer from polarization effects due to the trapping of charges at the diamond/metal interface, a periodical bias inversion can guarantee optimal performance. To facilitate that, a reversible high voltage power supply has been developed. The ongoing development of data acquisition equipment and real-time processing algorithms based on programmable gate arrays further enhances the neutron camera's capabilities. [ABSTRACT FROM AUTHOR]

Background: Implantable loop recorder (ILR) allows rhythm‐monitoring up to 3 years. They are recommended in patients with recurrent syncope and for the detection of atrial fibrillation (AF) in patients with cryptogenic thromboembolic events. AF and syncope occur more often in elderly patients. However, data in this cohort is limited. Methods and results: All patients ≥ 80 years undergoing ILR‐implantation between 2011 and 2022 in our center were included. Permanent pacemaker implantation (PPI) and oral anticoagulation due AF were defined as primary endpoints. Forty‐five patients ≥ 80 years were included, 33 because of recurrent syncope and 12 because of suspected AF. The average follow up (FU) was 17.6 months. Overall in 22 patients, ILR‐implantation led to a therapeutic consequence (48.9%). In the 12 patients who underwent ILR‐implantation for detection of AF, AF was detected in nine patients (75%). In the 33 elderly patients who received ILR‐implantation after syncope, 11 underwent PPI during FU (33.3%). One patient accidentally removed the ILR himself via the implantation‐wound, and no other ILR‐related complications were observed. Conclusion: ILR are effective and safe in elderly patients. AF was often found in patients with suspected AF, especially in patients after catheter ablation of only documented atrial flutter (AFlu). PPI‐rate was high in patients with recurrent syncope and ILR‐implantation. Further investigations are necessary to determine whether PPI may be considered in elderly patients with syncope even in the absence of a bifascicular block. [ABSTRACT FROM AUTHOR]

Aim: COVID-19 has been associated with cardiovascular complications including ventricular arrhythmias (VA) and an increased number of out-of-hospital cardiac arrests. Nevertheless, several authors described a decrease of VA burden in patients with an implantable defibrillator (ICD) during the first wave of the COVID-19 pandemic. The objective of this study was to determine if these observations could be transferred to later periods of the pandemic as well. Methods: We retrospectively analyzed a total of 1674 patients with an ICD presenting in our outpatient clinic during the second wave of the COVID-19 pandemic and during a control period for the occurrence of VA requiring ICD interventions. Results: Seven hundred ninety-five patients with an ICD had a device interrogation in our ambulatory clinic during the second wave of the COVID-19 pandemic compared to eight hundred seventy-nine patients in the control period. There was significant higher amount of adequate ICD therapies in the course of the COVID-19 period. Thirty-six patients (4.5%) received in total eighty-five appropriate ICD interventions during COVID-19, whereas only sixteen patients (1.8%) had sustained VA in the control period (p = 0.01). Conclusion: In contrast to the first wave of COVID-19, which was characterized by a decrease or least stable number of ICD therapies in several centers, we found a significant increase of VA in ICD patients during the second wave of COVID-19. Possible explanations for this observation include higher infectious rates, potential cardiac side effects of the vaccination as well as personal behavioral changes, or reduced utilization of medical services. [ABSTRACT FROM AUTHOR]

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (techniques that aim to alter the respiratory pattern, excluding respiratory muscle training) in people with serious respiratory illness. The primary outcome was breathlessness and secondary outcomes were health-related quality of life and adverse events. Two authors independently screened for inclusion, evaluated risk of bias and extracted data. Results 73 randomised controlled trials were included with 5479 participants, most with COPD or asthma. Breathing exercises (pursed lip and/or diaphragmatic breathing) reduced breathlessness measured by the modified Medical Research Council scale compared to usual care (mean difference (MD) -0.40 points, 95% CI -0.70--0.11, eight studies, n=323), although the effect did not exceed the minimal important difference. Yoga breathing also improved modified Medical Research Council score compared to usual care (MD -1.05 points, 95% CI -2.45-0.35, three studies, n=175). Breathing techniques consistently improved health-related quality of life in people with COPD and asthma on multiple health-related quality of life measures in comparison to usual care, with effects that generally exceeded the minimal important difference. No adverse events related to breathing techniques were reported. Conclusion Breathing techniques may improve breathlessness, and consistently improve health-related quality of life, in people with serious respiratory illness. These findings support the use of breathing exercises in the care of people with serious respiratory illness. [ABSTRACT FROM AUTHOR]

Background People living with serious respiratory illness experience a high burden of symptoms. This review aimed to determine whether multicomponent services reduce symptoms in people with serious illness related to respiratory disease. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) evaluating multicomponent services that enrolled patients due to symptoms, rather than underlying disease, and provided at least one nonpharmacological intervention. The primary outcome was chronic breathlessness and secondary outcomes were health-related quality of life (HRQoL), cough, fatigue and adverse events. At least two authors independently screened studies, assessed risk of bias and extracted data. Results Five RCTs, involving 439 patients, were included. In comparison to usual care, multicomponent services improved breathlessness mastery (Chronic Respiratory Questionnaire (CRQ) mastery scale, mean difference (MD) 0.43 points, 95% CI 0.20-0.67, three RCTs, 327 participants) and HRQoL (CRQ total score, MD 0.24 points, 95% CI 0.04-0.40, two RCTs, 237 participants). Fatigue did not improve with multicomponent services and no studies evaluated cough. No serious adverse events were reported. The one study evaluating mortality found increased survival in those accessing a multicomponent service. The certainty of evidence was very low, mainly due to detection and reporting bias. Conclusion Multicomponent services improve breathlessness mastery and HRQoL, with minimal risk. These findings support the use of multicomponent symptom-directed services for people living with serious respiratory illness. [ABSTRACT FROM AUTHOR]

Satellite remote sensing is a critical tool for continental and synoptic monitoring and mapping of savannah wildfires. Satellite active fire products, which report on the time and location of a fire and may further characterise fire by estimating fire radiative power (FRP), provide valuable utility for savannah fire management and carbon accounting. These applications require that satellite measurements are of high accuracy, which can only be determined through validation. However, acquiring reference data for validation that is a representative of the fire conditions at the time of satellite image capture is challenging, due to rapid changes in fire behaviour and the inherent safety considerations of collecting field data during fire events. This review explores traditional and contemporary methods used to assess the accuracy and consistency of fire detections and FRP derived from satellite data in savannah ecosystems, with a focus on the approaches and challenges in collecting suitable reference data for a phenomenon as dynamic, ephemeral, and hazardous as wildfire. From this synthesis, we present generalised frameworks for the validation and intercomparison of satellite active fire products within savannah ecosystems. This article reviews traditional and contemporary methods that have been used to assess the accuracy of satellite active fire products and the consistency between products. We provide through this review generalised frameworks that advise on good practice for validating satellite fire products within the savannah biome. This article belongs to the Collection Savanna Burning. [ABSTRACT FROM AUTHOR]

The SPARC tokamak is a high-field, Bt0 ∼12 T, medium-sized, R0 = 1.85 m, tokamak that is presently under construction in Devens, MA, led by Commonwealth Fusion Systems. It will be used to de-risk the high-field tokamak path to a fusion power plant and demonstrate the commercial viability of fusion energy. SPARC's first campaign plan is to achieve Qfus > 1 using an ICRF-heated, <10 MW, high current, Ip ∼ 8.5 MA, L-mode fueled by D–T gas injection, and its second campaign will investigate H-mode operations in D–D. To facilitate plasma control and scientific learning, a targeted set of ∼50 plasma diagnostics are being designed and built for operation during these campaigns. While nearly all diagnostics are based on established techniques, the pace of deployment, relative to the first plasma, and the harshness of the thermal, electromagnetic, and radiation environment are unprecedented for medium-sized tokamaks. An overview of the SPARC diagnostic set is given, providing context to further details communicated by the SPARC team in companion publications that are system-specific. The system engineering philosophy for SPARC diagnostics is outlined, and the design and engineering verification process for components inside and outside the primary vacuum boundary are described. Diagnostics are mounted directly to the vacuum vessel as well as housed within a series of eight midplane and 24 off-midplane replaceable port plugs. With limited exceptions, signal conditioning, digitization electronics and cameras as well as lasers and microwave sources are localized to a series of five Diagnostic Lab spaces, totaling ∼350 m2, located >15 m from the center of the tokamak, on the other side of a 2.4 m concrete shielding wall. A series of 31 large-scale penetrations have been included in the SPARC Tokamak Hall to facilitate integration of early campaign diagnostics and to provide upgradability. [ABSTRACT FROM AUTHOR]

A suite of plasma diagnostics will be installed on the SPARC tokamak to allow for real-time plasma control, an investigation of high-field tokamak physics, and to de-risk the design of ARC, a compact fusion power plant with the aim to supply electricity to the grid. Among these diagnostics is the neutral gas diagnostics system (NTGS), a set of pressure sensors and gas analyzers used to monitor neutral pressure and gas composition for plasma control, optimization of wall conditioning, and helium ash removal, among other measurement functions linked to operational and scientific research needs. While reliable measurements of neutral pressure and gas composition have been fielded on existing magnetic-confinement fusion devices, SPARC represents a step increase in challenge due to its larger power density, higher field, high vacuum vessel bake temperatures, and higher neutron flux environment, as well as a step decrease in the accessibility for maintenance of in-vessel sensors. Multiple sensor types will be employed to have defense-in-depth and mitigate common failure modes. The NTGS system is currently progressing through final design, working to close out decisions using prototyping and analysis, and then moving on to procuring sensors for assembly and installation on SPARC. This paper outlines the current status of the system design and the diagnostic requirements that motivate neutral gas measurements on SPARC, as well as highlights the planned prototyping activities. [ABSTRACT FROM AUTHOR]

Neutron measurement is the primary tool in the SPARC tokamak for fusion power (Pfus) monitoring, research on the physics of burning plasmas, validation of the neutronics simulation workflows, and providing feedback for machine protection. A demanding target uncertainty (10% for Pfus) and coverage of a wide dynamic range (>8 orders of magnitude going up to 5 × 1019 n/s), coupled with a fast-track timeline for design and deployment, make the development of the SPARC neutron diagnostics challenging. Four subsystems are under design that exploit the high flux of direct DT and DD plasma neutrons emanating from a shielded opening in a midplane diagnostic port. The systems comprise a set of ∼15 flux monitors, mainly ionization chambers and proportional counters for measurement of the neutron yield rate, two independent foil activation systems for measurement of the neutron fluence, a spectrometric radial neutron camera for poloidal profiling of the plasma emissivity, and a high-resolution magnetic proton recoil spectrometer for measurement of the core neutron spectrum. Together, the four systems ensure redundancy of sensors and methods and aim to provide high resolutions of time (10 ms), space (∼7 cm), and energy (<2% at 14 MeV). This paper presents the broader objectives behind the preliminary design of the SPARC neutron diagnostics and discusses the ongoing studies on neutronics, detector comparisons, prototyping, and integration with the unique infrastructure of SPARC. Engineering details of the four subsystems and the concepts for in situ neutron calibration are also highlighted. [ABSTRACT FROM AUTHOR]

The SPARC tokamak will have scrape-off layer parallel heat fluxes on the order of GW/m2. Managing power exhaust of this magnitude will be mandatory for a reactor-scale device. To enable this mission, a thermal diagnostic suite will be deployed to measure the in-vessel structural temperatures to ensure they do not exceed their design limits and to determine the spatial distribution and magnitude of energy deposited onto the first wall. Thermocouples and fiber Bragg gratings have been selected for their environmental compatibility and proven useful on other fusion devices. High-density thermocouple arrays in the divertor will have two spring-loaded thermocouples per divertor target tile, which are being used as calorimeters, and will look to resolve the temperature distribution within the tile due to a swept or static strike point. All systems will need to survive the vacuum vessel bake, set at a minimum plasma facing surface temperature of 350 °C, which presents a particularly challenging environment for the fiber-based subsystem. Along with this temperature design requirement, all the materials in the primary vacuum need to be ultra-high vacuum compatible, able to handle the expected neutron and gamma radiation, as well as tritium exposure, all of which restrict material options. Finally, due to the expected activated environment in SPARC, there will be little chance to replace defective sensors, so system resilience is ensured through toroidal redundancy, probe material selection, and mitigating the impact of common-mode failures. Initial testing of sensors show that intershot structural measurements are sufficiently captured with the raw output, but intrashot measurements of the plasma facing material requires model-based interpretive tools. [ABSTRACT FROM AUTHOR]

Background: Patients with acute cholecystitis (AC) presenting with unfavorable systemic or local conditions are often managed with percutaneous cholecystostomy (PC) as a temporary measure. The clinical outcomes of interval cholecystectomy following PC remain unclear. The aim of the study was to identify the association between the timing of cholecystectomy following PC for AC and perioperative complication rates at interval cholecystectomy. We hypothesized that there would be a specific time interval to cholecystectomy associated with lower risk for adverse events. Methods: This was a retrospective (2018–2020) multicenter study at 8 participating hospital systems of adult patients with AC, managed with PC and interval cholecystectomy. Demographics, comorbidities, treatment details, and outcomes were examined. Patients were grouped based on quartiles for timing of surgery after PC (< 7, 7–9, 10–13, > 13 weeks). The primary outcome was a composite endpoint of bile duct injury, reoperation, readmission, image-guided intervention, endoscopic intervention, conversion to open surgery, or death. Results: There were 188 patients with a median age of 66 years with AC classified as mild (41%), moderate (47%), and severe (12%). Median days from PC to surgery were 65 (Q1 = 48, Q3 = 91). Laparoscopic cholecystectomy (89.9%) was the most commonly planned approach (robotic 6.4%, 3.7% open) and 28 (14.9%) were converted to open. The composite endpoint was reported in 51 patients (27.1%). A biliary injury occurred in 7 (3.7%) patients. Time to surgery and intraoperative drain placement were independently associated with the composite outcome. Cholecystectomy within 7 weeks of PC was associated with decreased risk (OR = 0.36, 95% CI 0.13–0.97) of the composite endpoint, compared to patients undergoing surgery > 13 weeks after PC. Conclusion: Timing of surgery following PC was associated with procedural outcomes. Patients undergoing surgery before 7 weeks experienced significantly less morbidity than patients having delayed cholecystectomy. These results should be considered in patient selection and management after PC. [ABSTRACT FROM AUTHOR]

In recent decades, the administrative and competitive structures of men's elite club football in Europe have undergone a profound transformation toward Europeanization. As a result, football fans are increasingly exposed to European influences. These dynamics shape fans' perceptions of and orientations toward Europe and contribute to constructions of collective identities. Because football is a highly mediatized sport, fans' exposure to European influences and their constructions of identity are highly dependent on the representation of Europe in football media. To analyze this, we conducted a quantitative analysis of text-based online news media. Using selected German media outlets, we examined the extent and the patterned variation of media representation of Europe in football news articles. Our results indicate a highly selective media environment focused on a limited set of countries with high sporting relevance and a presence of German national-team players, while other countries rarely enter the media discourse. [ABSTRACT FROM AUTHOR]

Background: Education has been shown to be positively associated with cognitive performance. However, the pathways via lifestyle-related disease through which education is related to cognitive performance have not been sufficiently explored. Diabetes is an important lifestyle-related disease with increasing prevalence worldwide. Low education is associated with an increased risk of developing diabetes, while diabetes may also lead to a deterioration in cognitive performance. This study aims to explore if the associations between education and cognitive function is mediated by the diabetes status among older adults. Methods: The data utilized in this study were derived from the first two waves of the Dutch Lifelines Cohort Study (2006–2015). The analyzed sample included 26,131 individuals aged 50 years or above at baseline. The baseline assessment included measurements of educational attainment (exposure) and the potential mediator diabetes. The outcome of cognitive function was assessed using age-standardized reaction times from the psychomotor function and attention tasks, as measured by the Cogstate Brief Battery. The Cogstate Brief Battery was only conducted at the follow-up assessment, not at the baseline assessment. Faster reaction times correspond to higher cognitive performance. The study employed linear and logistic regression models, in addition to a causal mediation approach which estimated the average causal mediation effect (ACME). Results: Higher education was associated with a lower risk of diabetes (b= -0.1976, 95%CI= -0.3354; -0.0597) compared to low or middle education as well as with faster reaction times (b= -0.2023, 95%CI= -0.2246; -0.1798), implying better cognitive function. Diabetes was associated with slower reaction times (b = 0.0617, 95%CI = 0.0162; 0.1072). Most importantly, the mediation approach identified a significant indirect effect of education on cognitive function via the diabetes status (ACME= -0.00061, 95%CI= -0.00142; -0.00011). Discussion: The findings emphasize the potentially importance of diabetes in explaining the role of education in promoting healthy cognitive function and mitigating the risk of cognitive decline. Early detection and treatment of diabetes may be particularly beneficial for individuals with low or middle levels of education in order to maintain good levels of cognitive function. [ABSTRACT FROM AUTHOR]

The microbiome is the collection of microbes that are associated with a host. Microsporidia are intracellular eukaryotic parasites that can infect most types of animals. In the last decade, there has been much progress to define the relationship between microsporidia and the microbiome. In this review, we cover an increasing number of reports suggesting that microsporidia are common components of the microbiome in both invertebrates and vertebrates. These microsporidia infections can range from mutualistic to pathogenic, causing several physiological phenotypes, including death. Infection with microsporidia often causes a disruption in the normal microbiome, with both increases and decreases of bacterial, fungal, viral, and protozoan species being observed. This impact on the microbiome can occur through upregulation and downregulation of innate immunity as well as morphological changes to tissues that impact interactions with these microbes. Other microbes, particularly bacteria, can inhibit microsporidia and have been exploited to control microsporidia infections. These bacteria can function through regulating immunity, secreting anti‐microsporidia compounds, and, in engineered versions, expressing double‐stranded RNA targeting microsporidia genes. We end this review by discussing potential future directions to further understand the complex interactions between microsporidia and the other members of the microbiome. [ABSTRACT FROM AUTHOR]

The article introduces 17th-century American Quaker abolitionist John Woolman and explores his socio-spiritual journey that led across U.S. colonies, as well as his embodiment of affirmative mysticism in British America. Topics discussed include the sickness of Woolman that resulted in visions of God for the Religious Society of Friends, his mission to preach love and freedom, and his opposition to human bondage and the slave trade.

An overview is given of SPARC's three main x-ray diagnostics, with a focus on the functions they fulfill with respect to tokamak operation. The first is an in-vessel soft x-ray tomography diagnostic, aimed at providing early campaign information on plasma position, MHD activity, and impurity content. The second is an ex-vessel set of hard x-ray scintillators aimed at detecting the presence of runaway electrons, in particular during plasma startup phases. The third is a set of x-ray Bragg spectrometers, located outside of the tokamak hall, aimed at informing on the ion temperature as an indirect constraint to reduce uncertainties on the fusion power, on providing plasma rotation velocity estimates, and on observing impurity emission. Finally, more technical details are given on the beamlines at the end of which the spectrometers are located. It explains how their design allows us to ensure tritium containment and limit neutron radiation while providing a straight view into the plasma that can also be used for testing new innovative sensors. [ABSTRACT FROM AUTHOR]

In our mobile working world, boundaries between work and non‐work domains are more and more blurred, which can impair professionals' recovery and well‐being. Consequently, managing work–non‐work boundaries represents an important challenge for professionals. Research suggests that boundary work tactics conveyed in boundary management interventions may promote recovery and well‐being. However, the efficacy of boundary work tactics is largely unknown, as well as theoretical mechanisms that may explain the effectiveness of boundary management interventions in regard of both training design and training transfer. Building on the social cognitive theory of self‐regulation, we develop a web‐based boundary management training. Based on the integrated training transfer and effectiveness model, we evaluate its effects on the three levels of training effectiveness: (1) perceived learning, (2) cognitions and behaviours, with boundary control and boundary creation as indicators, and (3) recovery and well‐being. Results of our randomized controlled intervention study show several expected changes in boundary creation, suggesting that drawing on the social cognitive theory of self‐regulation for training design can result in effective behaviour change. Intervention effects on recovery and well‐being are more ambiguous, hinting at the power but likewise potential limitations of boundary creation. [ABSTRACT FROM AUTHOR]

To control and optimize the power of the SPARC tokamak, we require information on the total radiated power of the plasma and its 2D and 3D spatial distribution. The SPARC bolometry diagnostic is being designed and built to measure the radiated power for controlling power balance, investigating the dissipation capabilities of various divertor concepts, and measuring the efficacy of the disruption thermal load mitigation. Proven resistive bolometer sensor technology will be used, with 248 lines of sight integrated into pinhole cameras in 20 different locations. This diversity of views will allow the bolometers to view the core, divertor, and particularly X-points of the plasma with high resolution. 14 of these camera locations are dedicated to 2D equilibrium radiated power, while the remaining six locations are designed to measure 3D radiated energy during disruptions. The bolometer sensor holders, pinhole camera boxes, and cabling have been designed to survive the high neutron flux (but low fluence) and up to 400 °C temperatures seen during operation and vacuum bake. The resistive bolometer sensors use Au absorbers with an Al heat conduction layer and C anti-reflective layer. These sensor chips are wire-bonded to an AlN circuit board, both of which are held inside a custom AlN and stainless steel bolometer holder. Design and optimization of the pinhole camera lines of sight are performed using Cherab. This work details the current state of the design of the SPARC bolometry diagnostic and its interfaces, as well as ongoing work to validate the design. [ABSTRACT FROM AUTHOR]

SPARC will be outfitted with three systems of x-ray crystal spectrometer arrays. Two of these are designed using cylindrically bent crystals to achieve high spectral-resolution for ion temperature and toroidal velocity measurements via imaging He-like Kr and Ne-like Xe. The last acts as a spectral survey system to monitor Ne-like W and nearby H- and He-like emission from Cr, Fe, Co, Ni, and Cu. Line radiation intensities are calculated using the Flexible Atomic Code for atomic data and ColRadPy for collisional-radiative modeling, then convoluted with a Voigt line shape. Free–free, free-bound, and two-photon continuum radiation is also included. The ToFu code is used to perform volume-of-sight integration to produce synthetic detector images. In addition, presented is cross-validation performed using the XICSRT Monte Carlo ray-tracing code. Ion temperature and toroidal velocity profiles are reconstructed using ToFu via tomographic inversion. [ABSTRACT FROM AUTHOR]

Edge scanning reflectometry (ESRL) on the SPARC tokamak aims to measure the electron density profile from the far scrape-off layer to the top of the typical H-mode pedestal and provide real-time data for plasma control. ESRL uses a standard frequency-modulated continuous wave technique from 18 to 90 GHz. By implementing both the O-mode and left-hand-cutoff X-mode, it covers densities from ∼4 × 1018 to ∼4 × 1020 m−3 at B0 ∼12 T. A voltage-controlled oscillator acts as the frequency sweep source. Phase-locked dielectric resonator oscillators and bandpass filters generate base signals ∼9–15 GHz. The signals are then frequency multiplied and amplified to reach the K (18–26 GHz), Ka (26–40 GHz), U (40–60 GHz), and E (60–90 GHz) bands. Multi-band signals are combined via the quasi-optical technique. ESRL plans to use oversized waveguides (∼20 m one-way) and a bi-static arrangement to minimize signal losses and distortions while allowing system flexibility. A COMSOL Multiphysics RF model in 2D has been set up to simulate the reflectometry process and help decide the layout of the horn antennas. Engineering analyses of the key parts of the system have been carried out in support of its preliminary design. [ABSTRACT FROM AUTHOR]

A new 14 MeV neutron spectrometer utilizing the magnetic proton recoil (MPR) technique is under development for the SPARC tokamak. This instrument measures neutrons by converting them into protons, whose momenta are subsequently analyzed using a series of magnets before detection by an array of scintillators known as the hodoscope. In this work, we explore various solutions for the hodoscope detectors through laboratory tests with radioactive sources and simulations. We present findings on light collection and pulse shape discrimination based on detector types, as well as optimal solutions for photo-detectors studying the differences between SiPM and PMT. Our results also led to the determination of a better optimized design for the hodoscope detectors, consisting of a 0.7 cm width and a 13 cm length EJ276D scintillation rod. [ABSTRACT FROM AUTHOR]

The design of a vacuum ultraviolet spectroscopy system has been performed to monitor and provide feedback for impurity control in SPARC. The spectrometer, covering a wavelength range of 10–2000 Å through a flat-field configuration with diffraction gratings, incorporates five survey lines of sight. This allows for comprehensive impurity analysis across the core and four divertor regions (inner/outer and upper/lower). Its compact modular design facilitates vertical stacking of each spectrometer unit, significantly reducing space in the tokamak hall, where a dedicated radiation shielding bunker will be built. Safety features include a secondary helium enclosure to mitigate tritium permeation risks during deuterium–tritium (D–T) operations and shielding within the beamlines for enhanced radiation protection. The silicon carbide mirror design for divertor observation ensures its survivability in the in-vessel environment of SPARC, validated by thermal and electromagnetic analysis. Signal modeling and data acquisition testing results show that an exposure time of a few milliseconds is appropriate considering photon flux reaching the detector, demonstrating the system's capability for discharge control that includes disruption avoidance. [ABSTRACT FROM AUTHOR]

Satellite imagery allows us to view landscapes from a bird’s eye view, providing a new dimension in appreciating the environments we inhabit. This alternative perspective has the potential to shape individual perceptions of landscapes and play a pivotal role in land management decision-making and communication. However, the interpretation and appreciation of landscapes seen in satellite imagery may vary among observers. This study investigates the relationship between individuals’ ability to interpret images from eye-level and satellite perspectives, their familiarity with the landscape, and their appreciation of land cover from this viewpoint. To achieve this, a survey was conducted presenting respondents with images of land cover classes captured at eye level and from satellite imagery of the Yungay municipality in Chile. Participants were asked to interpret the primary land use land cover (LULC) depicted in the imagery and indicate their appreciation of that landscape. Variation in the interpretation of LULC was observed between the image source and land cover type. For instance, forest classes seen in eye-level imagery were more accurately interpreted compared to satellite imagery, while the reverse was true for agriculture. These differences in interpretation also impacted the appreciation scores assigned to the landscapes in the images. Specifically, if respondents perceived an image to be dominated by a traditionally appreciated land cover (e.g., Native Vegetation), they provided a higher score, even if the image depicted another class (e.g., Plantation Forestry). These findings highlight that considering the influence of satellite imagery in shaping perception is crucial in supporting land management activities. [ABSTRACT FROM AUTHOR]

The piRNA pathway is a conserved germline-specific small RNA pathway that ensures genomic integrity and continued fertility. In C. elegans and other nematodes, Type-I piRNAs are expressed from >10,000 independently transcribed genes clustered within two discrete domains of 1.5 and 3.5 MB on Chromosome IV. Clustering of piRNA genes contributes to their germline-specific expression, but the underlying mechanisms are unclear. We analyze isolated germ nuclei to demonstrate that the piRNA genomic domains are located in a heterochromatin-like environment. USTC (Upstream Sequence Transcription Complex) promotes strong association of nucleosomes throughout piRNA clusters, yet organizes the local nucleosome environment to direct the exposure of individual piRNA genes. Localization of USTC to the piRNA domains depends upon the ATPase chromatin remodeler ISW-1, which maintains high nucleosome density across piRNA clusters and ongoing production of piRNA precursors. Overall, this work provides insight into how chromatin states coordinate transcriptional regulation over large genomic domains, with implications for global genome organization. Author summary: Here we address how gene expression is coordinated over long stretches of DNA that is embedded in a dense chromatin environment. We focus on a large DNA domain that contains thousands of tiny noncoding piRNA genes that are only expressed in germ cells. Our work demonstrates that a specific factor called USTC works with chromatin remodeling factors and with the core transcription complex to activate piRNA gene expression. The ISW-1 chromatin remodeler creates a dense environment that is favorable for USTC to be recruited to piRNA genes. USTC then clears the chromatin away from a space around each piRNA gene that allows for the factor TBP-1 to bind and presumably recruit the core transcriptional machinery to turn on the short piRNA. This work illuminates a mechanism by which both local and long-distance regulatory information can be integrated to coordinate gene expression. [ABSTRACT FROM AUTHOR]

Squeeze film dampers are used to reduce vibration in aircraft jet engines supported by rolling element bearings. The underlying physics of the squeeze film dampers has been studied extensively over the past 50 years. However, the research on the SFDs is still ongoing due to the complexity of modeling of several effects such as fluid inertia and the modeling of the piston rings, which are often used to seal SFDs. In this work, a special experimental setup has been designed to validate the numerical models of SFDs. This experimental setup can be used with various SFD geometries (including piston ring seals) and simulate almost all conditions that may occur in an aircraft jet engine. This work also focuses on the inertia forces of the fluid. The hydrodynamic pressure distribution of a detailed 3D-CFD model is compared with the solution of the Reynolds equation including inertia effects. Finally, the simulation results are compared with experimental data and good agreement is observed. [ABSTRACT FROM AUTHOR]

We study the action of groups generated by bounded activity automata with infinite alphabets on their orbital Schreier graphs. We introduce an amenability criterion for such groups based on the recurrence of the first‐level action. This criterion is a natural extension of the result that all groups generated by bounded activity automata with finite alphabets are amenable. Our motivation comes from the investigation of iterated monodromy groups of entire transcendental functions in holomorphic dynamics. [ABSTRACT FROM AUTHOR]

This paper introduces iterated monodromy groups for transcendental functions and discusses them in the simplest setting, for post-singularly finite exponential functions. These groups are self-similar groups in a natural way, based on an explicit construction in terms of kneading sequences. We investigate the group theoretic properties of these groups, and show in particular that they are amenable, but they are not elementary subexponentially amenable. [ABSTRACT FROM AUTHOR]