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Aim: Our aim was to identify independent determinants of rapid weight gain in infants at 3‐4, 6, and 12 months of age. Methods: A cohort study was conducted on Mexican term infants in public and private settings between March 2021 and May 2023. Rapid weight gain was defined as a ≥0.67 SD change in weight‐for‐age‐Z‐score from birth to 3‐4, 6, and 12 months of age. Maternal and infant characteristics were described, and infant feeding practices, appetitive traits, weight, and length were analysed at 3‐4, 6, and 12 months of age. Rapid weight gain predictors were determined using generalised linear regression models. Results: In total, 168 infants were recruited (55% boys). Small‐for‐gestational‐age status increased rapid weight gain risk 1.5 times, whereas large‐for‐gestational‐age status represented a 20%–30% decrease. Slowness in eating decreased the risk by 10%. Protective factors were older maternal age and higher educational level, whereas formula feeding, early complementary feeding, greater food enjoyment, and satiety responsiveness increased the risk. Conclusions: Small for gestational age, slowness in eating, and feeding practices can be rapid weight gain predictors across the first year of life. [ABSTRACT FROM AUTHOR]

Copyright of Hachetetepé: Revista Científica de Educación y Comunicación is the property of Universidad de Cadiz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ataxia-telangiectasia (A-T) is a disease caused by mutations in the ATM gene (11q22.3-23.1) that induce neurodegeneration Sasihuseyinoglu AS et al. Pediatr Allergy Immunol Pulmonol 31(1):9–14, 2018, Teive HAG et al. Parkinsonism Relat Disord 46:3–8, 2018. Clinically, A-T is characterized by ataxia, mucocutaneous telangiectasia, immunodeficiency, and malignancy. Movement disorders have been the most described and well-studied symptoms of A-T. Other studies have reported visuospatial processing disorders, executive function disorders and emotional regulation disorders, which are clinical manifestations that characterize cerebellar cognitive affective syndrome (CCAS) Choy KR et al. Dev Dyn 247(1):33–46, 2018. To describe the neurocognitive and emotional state of pediatric patients with ataxia-telangiectasia and to discuss whether they have cerebellar cognitive affective syndrome. This observational, cross-sectional, and descriptive study included 9 patients with A-T from May 2019 to May 2021. A complete medical history was retrieved, and tests were applied to assess executive functions, visual-motor integration and abilities, language, psychological disorders, and ataxia. Six girls and 3 boys agreed to participate. The age range was 6 to 14 years. The participants included five schoolchildren and four teenagers. Eight patients presented impaired executive functioning. All patients showed some type of error in copying and tracing (distortion) in the performance of visual perceptual abilities. Emotional disorders such as anxiety and depression were observed in six patients. Eight patients presented with dyslalia and impairments in word articulation, all patients presented with ataxia, and seven patients used a wheelchair. All patients presented symptoms consistent with CCAS and had variable cognitive performance. [ABSTRACT FROM AUTHOR]

We present a web server that predicts the far‐UV circular dichroism (CD) spectra of proteins by utilizing their three‐dimensional (3D) structures from the Protein Data Bank (PDB). The main algorithm is based on the classical theory of optical activity together with a set of atomic complex polarizabilities, which are obtained from the analysis of a series of synchrotron radiation CD spectra and their related 3D structures from the PDB. The results of our knowledge‐based CD method (KCD) are in good agreement with measured spectra that could include the effect of D‐amino acids. Our method also delivers some of the most accurate predictions, in comparison with the calculated spectra from well‐established models. Specifically, using a metric of closeness based on normalized absolute deviations between experimental and calculated spectra, the mean values for a series of 57 test proteins give the following figures for such models: 0.26 KCD, 0.27 PDBMD2CD, 0.30 SESCA, and 0.47 DichroCalc. From another point of view, it is worth mentioning the remarkable capabilities of the recent approaches based on artificial intelligence, which can precisely predict the native structure of proteins. The structure of proteins, however, is flexible and can be modified by a diversity of environmental factors such as interactions with other molecules, mechanical stresses, variations of temperature, pH, or ionic strength. Experimental CD spectra together with reliable predictions can be utilized to assess eventual secondary structural changes. A similar kind of evaluation can be done for the case of an incomplete protein structure that has been reconstructed by using different approaches. The KCD method can be freely accessed from: https://kcd.cinvestav.mx/. [ABSTRACT FROM AUTHOR]

This study aimed to identify whether appetitive traits predict exclusive breastfeeding (EBF) duration for the first 6 months of life and to assess other predictors of its duration. 186 six- month-old term infants were included. Appetitive traits were assessed at 3–4 months of age. EBF duration, feeding practices, sex, maternal age and education, socioeconomic level, mode of delivery and gestational age were also evaluated. Risk ratios (RR) and 95% confidence intervals (CI) were estimated through generalized linear regression models to identify predictors of EBF for the first 6 months of life. Only 32.9% of infants achieved 6-month EBF. Vaginal birth, not using formula the first 3 days, maternal education ≥ university and slowness in eating significantly increased the probability of EBF for 6 months. Slowness in eating was the only appetitive trait related to EBF for the first 6 months and was the most significant predictor in the multivariate model. [ABSTRACT FROM AUTHOR]

The United Nations (UN) 2023 Water Conference was held from March 22–24 at the UN Headquarters in New York, USA. There was a clear message from Day 1 of the Conference: "we are not on track to achieving Sustainable Development Goal (SDG) 6 on water and sanitation for all." Moreover, business-as-usual approaches for water management do not seem effective facing the so-called triple planetary crisis of climate change, pollution, and biodiversity loss (What is the Triple Planetary Crisis? | UNFCCC). Hence, the Conference aimed to raise awareness of the global water crisis and to make agreements on concerted actions to mobilize all sectors, stakeholders, and countries toward the resolution of this global issue. Among them, the agreement to establish a UN Special Envoy for Water (different figure than the Special Rapporteur on the Human Right to Water), ground more than seven hundred voluntary commitments and pledges, and renew the political momentum in fora such as the High-Level Political Forum on Sustainable Development, held this July 2023, and the SDG Summit in September 2023 to follow up on the SDGs and Agenda 2030, as well as the commitments of the Decade for Action on Water (2018–2028).The UN, in fact, has promoted numerous initiatives to mobilize citizens around the SDGs. Presently, the UN has declared a total of 206 International Environmental Days to honor specific human and environmental subjects. Among them, only 40 are specifically related to the environment or socio-environmental issues. The majority of all of these declarations are followed by "mega-conferences"1 related to the same subjects: that is, RAMSAR/wetlands sites, sustainable development, biodiversity, climate change, and the latest one is water. The UN states that these commemorative dates and fora are meant to "educate the public on issues of concern, to mobilize political will and resources to address global problems, and to celebrate and reinforce achievements of humanity" (United Nations, 2023)). We have nothing against the raising of awareness and the need to take political action, but we would rather like to offer a reflection on two critical and historical challenges related to these global events: (a) the implementation of global water fora accords from global-to-local governance, and (b) the need for broader and inclusive participation of different stakeholders, with particular focus on water issues. [ABSTRACT FROM AUTHOR]

Simple Summary: Butter consumption has grown in recent years in Europe, and for some time now, a wide range of butters have been available on the market with a marked variability, due either to the species of origin or the manufacturing process. Applying the same analytical techniques to all, we assessed the quality of commercial butters available on the market in southern Spain. Differences were detected in nutritional value and technological parameters, many of which were linked to sensory quality. This information could be useful for the industry to learn more about the quality of each type of butter and to better promote the product. Butter is an important product for the dairy industry due to its particular sensory attributes and nutritional value, while the variability of the composition of the fatty acids in the milk can alter the nutritional and physical properties of butter and its acceptance by consumers. Butter is highly appreciated for its distinctive flavor and aroma; however, one of its main drawbacks lies in the difficulty in spreading it at low temperatures. Several types of butter that are present in the market were used in this study. We assessed the variability in the composition of the samples regarding their texture, color properties, and volatile organic compound profiles. We analyzed samples commercially produced from sheep's milk (SB), goat's milk (GB), and cow's milk (CB); samples from the latter species with (CSB) and without salt (CB); and the low-fat (CLB) version. All the physicochemical composition parameters were significantly affected by the effect of the type of butter, although only 29 out of the 45 fatty acids examined were identified in the butter samples analyzed. The textural properties of the butters were influenced by both their solid fat content and the fatty acid profile. In addition, the origin of the milk not only affected the texture parameters but also the color of the butters and the compounds associated with traits such as odor and flavor. Through the multivariate data analysis of butter fatty acids and volatile compound percentages, we observed a clear differentiation of the samples based on the species of origin. [ABSTRACT FROM AUTHOR]

We present a model of circular dichroism for proteins that is based on the classical electromagnetic theory for optical activity. The two additional constituents of the model are as follows: an appropriate characterization of the secondary structure of the protein residues and the assignment of an effective polarizability to each type of classified residue. The set of effective polarizabilities is obtained by means of a Monte Carlo statistical method, which is used to analyze a series of synchrotron radiation circular dichroism spectra together with their corresponding crystallographic structures. As a result, the predicted spectra from our model are in good accord with experimental data, as well as with the results of some other theoretical approaches. [ABSTRACT FROM AUTHOR]

Grapevine trunk diseases cause severe damage in grapevines. Management strategies focus on protection of grapevine pruning wounds using chemical fungicides or biological control agents. Botryosphaeria dieback, caused mainly by Lasiodiplodia spp., is one of the main trunk diseases in northwest Mexico. This study obtained endophytic bacteria and fungi from the heritage grapevine Vitis vinifera cv. ‘Mission’ for potential biological control of Botryosphaeria dieback. A collection of 135 bacterial and 37 fungal isolates were obtained and initially tested for antagonistic activity against Lasiodiplodia brasiliensis. The most promising isolates belonging to Trichoderma and Bacillus spp. were selected and characterized to determine their modes of action. Bacillus isolates produced volatile organic compounds that inhibited growth of Neofusicoccum parvum, and diffusible organic compounds with antifungal effects against L. brasiliensis and N. parvum. Trichoderma isolates produced diffusible organic compounds and were mycoparasites. In greenhouse assays, plants inoculated with three Trichoderma asperellum isolates (T20BCMX, EF09BCMX, and EF11BCMX), B. amyloliquefaciens (BEVP26BCMX) or Bacillus sp. (rbES015), applied preventively in soil, gave up to 50% smaller necrotic lesions when compared with the plants inoculated only with L. brasiliensis. In the field, plants inoculated with three Bacillus isolates (BEVP02BCMX, BEVP26BCMX, BEVP31BCMX) or five Trichoderma (T11BCMX, T15BCMX, T17BCMX, T20BCMX, and EF11BCMX) had lesions up to four times smaller than control plants inoculated only with L. brasiliensis. This study has demonstrated the potential of heritage grapevines to provide biological control agents for Botryosphaeria dieback. [ABSTRACT FROM AUTHOR]

The objective was to evaluate the anthropometric indicators and dietary intake of toddlers attending private clinics in Guadalajara. In a cross-sectional study, 101 toddlers aged 12 to 24 months were included. They were born full term, had an adequate weight for gestational age, and attended private clinics in Guadalajara. Two 24 h dietary recalls were administered. Anthropometric measurements were taken, and anthropometric indices were estimated. Student's t test or the Mann–Whitney U test, chi-square test, and odds ratio were used for quantitative or qualitative variables. Males had lower Z scores for the weight/age index than females. During the week, energy intake was excessive in males [OR = 5.5 (95% CI 1.4, 20.8)], and cholesterol intake was insufficient in females [OR = 3.03 (95% CI 1.2, 7.1)]. On weekends, energy [OR = 2.5 (95% CI 1.1, 5.7)] and fiber intake [OR = 3.1 (95% CI 1.2, 7.8)] were insufficient in females. Most of the toddlers who attend the private clinics in the upper-middle socioeconomic stratum of the Guadalajara Metropolitan Area had excessive protein intake, excessive consumption of added sugars was frequent, and there was insufficient intake of vitamin D and calcium. Sex was shown to be a factor influencing nutrient intake in these toddlers aged 12–24 months. Males had a Z-score of weight/age lower than females, suggesting nutritional risk. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Derecho de la Seguridad Social, Laborum is the property of Ediciones Laborum S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The relationship between emotional intelligence, executive functioning, and sensory processing has been independently studied. The present study investigated the relationship among executive functions, sensory processing and emotional intelligence in children aged between 8 and 11 years (n = 71). Executive functions and sensory processing were measured using EPYFEI and Clocks Subtest of NEPSY-II and emotional intelligence was measured with EQ:i-YV, Affect Recognition and Theory of Mind subtests of NEPSY-II. Children with lower emotional intelligence showed differences in sensory processing. The current research provides initial evidence of relations between emotional intelligence, stress management and sensory processing in children. [ABSTRACT FROM AUTHOR]

Background: Feeding practices in the first two years of life have a direct impact on nutritional status and adiposity. The purpose of this study was to identify the differences in feeding practices during the first two years of life by sex and type of feeding in the first semester of postnatal life and their relationships with adiposity in toddlers. Methods: An analytical cross-sectional study that included 150 toddlers aged 12 to 24 months who were healthy, full-term, and had adequate weight for their gestational ages, was conducted at the New Civil Hospital and at a private practice in Guadalajara. Body compositions were obtained by bioelectrical impedance (BIA) measurements, and a modified questionnaire was used. Then, the parents completed two 24-h dietary recalls. In addition to the descriptive statistics, ANOVA, Kruskal–Wallis and Mann–Whitney U tests were used in the contrast analysis of the quantitative variables. To analyze the qualitative variables, we used X2 tests. Afterward, linear regression tests were conducted to identify the relationships between adiposity and feeding practices during the first two years. Results: There were direct relationships between adiposity and duration of full breastfeeding (r = 0.610, p = 0.021), age of introduction of ultra-processed products (r = 0.311, p = 0.011), sugar (r = 0.186; p = 0.024) and age at which eggs were introduced (r = -0.202; p = 0.016). Conclusions: Adiposity was related to feeding practices in the first two years of life in toddlers. [ABSTRACT FROM AUTHOR]

Copyright of Revista Mexicana de Anestesiología is the property of Colegio Mexicano de Anestesiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The production of dry-fermented sausages currently presents several challenges to be addressed: nutrition, health, sensory traits and technology are among the main issues that concern consumers and the meat industry. The objective of this study was to evaluate the effect of different reducing agents commonly used in the manufacture of dry-fermented sausages (salchichon type) with low fat content on the technological characteristics of the product. Four different reducing agents (ascorbic acid, a starter culture, sodium ascorbate and glucono-delta-lactone) were added to the meat batter to assess their impact on the physico-chemical traits, instrumental color, residual nitrates and nitrites and lipid oxidation of this meat product. High nitrate values were observed during both ripening and storage periods. All batches presented lipid oxidation values below the threshold that indicates meat rancidity. Adjustments of the original lean:fat proportion must be carried out on this low fat content sausage to obtain profitable results. Starter culture and sodium ascorbate have shown the best reducing and antioxidant activities among the additives studied. Once we have the technical design of the product, the next step will be oriented to identify the sensory characteristics in order to find a gap in the market. [ABSTRACT FROM AUTHOR]

Dietary lipid sources influence intramuscular fatty acid composition, which in turn may affect the volatile profile of meat. The aim of this work was to investigate the effects of marine algae supplementation (Aurantiochytrium limacinum) on volatile compounds of cooked lamb meat. Forty-eight lambs with 42 days of age were divided into three groups: lambs fed a conventional diet without algae meal supplementation (NOALG), lambs with competent reticular groove reflex (RGR) fed the same diet supplemented with 2.5% marine algae meal mixed in the concentrate (ALGCON), and lambs with competent RGR, receiving the same diet and fed with 2.5% marine algae meal in a milk replacer to bypass the rumen (ALGMILK). Lipid and protein oxidation in raw meat was assessed and volatile compounds in grilled meat were determined. The highest and lowest lipid oxidations were observed in the ALGMILK and NOALG groups, respectively. Protein oxidation was unaffected. Out of 56 identified compounds, 12 volatiles significantly increased in both algae groups and 6 of them exclusively in the ALGCON treatment. Algae meal supplementation and its form of administration, either protected or not from rumen degradation, are important factors to consider in lipid oxidation and the aromatic profile of lamb meat. [ABSTRACT FROM AUTHOR]

Copyright of Espacio, Tiempo y Forma. Serie VII, Historia del Arte is the property of Editorial UNED and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Actas de Diseño is the property of Facultad de Diseno y Comunicacion, Fundacion Universidad de Palermo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In most of the world, we follow a production model based on economic premises from the middle of the nineteenth century, including processes of accumulation, monopolization, and privatization of a territory's common goods and of life itself, in order to guarantee the reproduction of capital. International regulations and laws that protect nature are mostly limited to reaction and repair of environmental damages caused by anthropocentric activities in the most vulnerable and impoverished nations in the world but do not o􀄞 en question the damage to populations, especially indigenous peoples and their ancestral territories. Latin America exemplifies this, given that the region has experienced a series of political, economic, environmental, and now health crises as it has become the epicenter of the current COVID-19 pandemic (Pan American Health Organization, PAHO, 2021). [ABSTRACT FROM AUTHOR]

Copyright of Revista Colombiana de Ciencias Pecuarias is the property of Universidad de Antioquia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

English Abstract: How do societies value and interact with ecosystem services (ES) to favor their long-term conservation? Under the premise that sociocultural assessment of ES offers an expanded perspective for potential societal nature contributions, we present here the empirical results of a participative assessment of ES in the Laguna de Nuxco coastal wetland in 2019. The methodological design includes the combination of applied qualitative tools on site and quantitative methods for analysis of information. The results emphasize that the ES of the wetland support socioeconomic needs and important socio-cultural community traits, such as cultural heritage and identity as fishing communities. We identify emerging socio-ecological conflicts that promote the decrease of ES. We suggest conceptual and methodological adaptations for the participative assessment of ES on the local scale Spanish Abstract: ¿Cómo las sociedades valoran e interactúan con los servicios ecosistémicos (SE) que les rodean para favorecer su conservación a largo plazo? Bajo la premisa que la valoración sociocultural de SE ofrece una perspectiva ampliada para potenciales contribuciones sociedad-naturaleza, presentamos aquí los resultados empíricos de una valoración participativa de SE del humedal costero Laguna de Nuxco en 2019. El diseño metodológico incluyó la combinación de herramientas cualitativas aplicadas en sitio y cuantitativas para el análisis de información. Los resultados enfatizan que los SE del humedal sustentan necesidades socioeconómicas e importantes aspectos socioculturales como patrimonio cultural e identidad como comunidades pesqueras. Identificamos conflictos socioecológicos emergentes que promueven la disminución de SE. Sugerimos adecuaciones conceptuales y metodológicas para la valoración participativa de SE en la escala local. English Abstract: How do societies value and interact with ecosystem services (ES) to favor their long-term conservation? Under the premise that sociocultural assessment of ES offers an expanded perspective for potential societal nature contributions, we present here the empirical results of a participative assessment of ES in the Laguna de Nuxco coastal wetland in 2019. The methodological design includes the combination of applied qualitative tools on site and quantitative methods for analysis of information. The results emphasize that the ES of the wetland support socioeconomic needs and important socio-cultural community traits, such as cultural heritage and identity as fishing communities. We identify emerging socio-ecological conflicts that promote the decrease of ES. We suggest conceptual and methodological adaptations for the participative assessment of ES on the local scale Spanish Abstract: ¿Cómo las sociedades valoran e interactúan con los servicios ecosistémicos (SE) que les rodean para favorecer su conservación a largo plazo? Bajo la premisa que la valoración sociocultural de SE ofrece una perspectiva ampliada para potenciales contribuciones sociedad-naturaleza, presentamos aquí los resultados empíricos de una valoración participativa de SE del humedal costero Laguna de Nuxco en 2019. El diseño metodológico incluyó la combinación de herramientas cualitativas aplicadas en sitio y cuantitativas para el análisis de información. Los resultados enfatizan que los SE del humedal sustentan necesidades socioeconómicas e importantes aspectos socioculturales como patrimonio cultural e identidad como comunidades pesqueras. Identificamos conflictos socioecológicos emergentes que promueven la disminución de SE. Sugerimos adecuaciones conceptuales y metodológicas para la valoración participativa de SE en la escala local. French Abstract: Comment les sociétés valorisent-elles et interagissent-elles avec les services écosystémiques (SE) pour favoriser leur conservation à long terme? Le principe de l'évaluation socioculturelle des SE off re une perspective élargie des contributions potentielles société-nature, et est utilisé pour présenter les résultats empiriques d'une évaluation participative des SE réalisée en 2019 dans la zone humide côtière de Laguna de Nuxco, au Mexique. La méthodologie comprenait la combinaison d'outils qualitatifs sur site et d'outils quantitatifs pour l'analyse de l'information. Les résultats soulignent que les SE de la zone humide répondent aux besoins socio-économiques et à des aspects socioculturels tels que le patrimoine culturel et l'identité en tant que communautés de pêcheurs. Nous identifions les conflits socio-écologiques émergents qui favorisent la diminution des SE. Nous suggérons des adaptations conceptuelles et méthodologiques pour l'évaluation participative des SE à l'échelle locale. [ABSTRACT FROM AUTHOR]

Pre-blockade of the sarco-endoplasmic reticulum (ER) calcium ATPase (SERCA) with irreversible thapsigargin depresses exocytosis in adrenal bovine chromaffin cells (BCCs). Distinct expression of voltage-dependent Ca2+-channel subtypes and of the Ca2+-induced Ca2+ release (CICR) mechanism in BCCs versus mouse chromaffin cells (MCCs) has been described. We present a parallel study on the effects of the acute SERCA blockade with reversible cyclopizonic acid (CPA), to repeated pulsing with acetylcholine (ACh) at short (15 s) and long intervals (60 s) at 37 °C, allowing the monitoring of the initial size of a ready-release vesicle pool (RRP) and its depletion and recovery in subsequent stimuli. We found (i) strong depression of exocytosis upon ACh pulsing at 15-s intervals and slower depression at 60-s intervals in both cell types; (ii) facilitation of exocytosis upon acute SERCA inhibition, with back to depression upon CPA washout in MCCs; (iii) blockade of exocytosis upon acute SERCA inhibition and pronounced rebound of exocytosis upon CPA washout in BCCs; (iv) basal [Ca2+]c elevation upon stimulation with ACh at short intervals (but not at long intervals) in both cell types; and (v) augmentation of basal [Ca2+]c and inhibition of peak [Ca2+]c amplitude upon CPA treatment in both cell types, with milder effects upon stimulation at 60-s intervals. These results are compatible with the view that while in MCCs the uptake of Ca2+ via SERCA contributes to the mitigation of physiological ACh triggered secretion, in BCCs the uptake of Ca2+ into the ER facilitates such responses likely potentiating a Ca2+-induced Ca2+ release mechanism. These drastic differences in the regulation of ACh-triggered secretion at 37 °C may help to understand different patterns of the regulation of exocytosis by the circulation of Ca2+ at a functional ER Ca2+ store. [ABSTRACT FROM AUTHOR]

Copyright of Revista Colombiana de Química is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Functional worker sterility in queenright honey bees (Apis mellifera) is fostered by the colony-level costs of this behavior. However, anarchy in the beehive can occur when a fraction of workers lay eggs, which, if reared, will develop into males (drones). Because males do not gather resources but still consume them, they represent an additional energic cost for the colony. This small number of anarchic worker-laid eggs is normally found and eaten by non-anarchic bees via worker policing, a controlling mechanism induced by queen's pheromones. However, worker policing by anarchic bees is possible by mimicking the pheromone marker of the queen. Here, we show that the intensity of worker policing has an upper-bound limit set by the loss in its population-level benefits. We developed a mathematical model to assess the benefits of worker policing at different intensities and costs of anarchy in the beehive. We found that there is an optimal rate in which workers should police in order to maximize colony-level benefits. The adjustment of worker policing intensity depending on the degree of anarchy in the population can keep the number of drones descending from workers low. However, this control can collapse when worker policing gets saturated due to high frequencies of anarchism. Our findings can help to advance the understanding on the maintenance of eusociality in bees by showing how the balance between anarchic behavior and worker policing regulates productivity in the beehive. [ABSTRACT FROM AUTHOR]

Collaborative Online International Learning (COIL) is an education model that provides a framework for international academic exchanges. Though COIL projects outline some best practices for academic partnerships, there are still several areas of project development in which participating faculty must make important decisions that affect the success of the academic venture. Perhaps one of the most important, yet frequently overlooked, aspects of international academic exchanges are the considerations made for differences in academic cultural practices. The current article details a COIL project in which binational faculty and students shared a semester‐long course. At the conclusion of the course, the two student groups reported vast differences in their experiences. In an effort to explain students' divergent perspectives, the author examines the academic climate reported by students and how academic practices implemented in the COIL project affected the overall success of the course. The Challenge: What are potential difficulties associated with creating meaningful Collaborative Online International Learning (COIL) programs? Are program difficulties mainly associated with linguistic and cultural differences? When gains are reported, are those gains similar across participating student groups? This article presents how Mexican and U.S. students' perceptions of their COIL experiences were affected by academic and institutional differences. [ABSTRACT FROM AUTHOR]

Introduction: Breast cancer is the first cause of cancer death in women. The triple-negative subtype is associated with aggressive behavior and poor prognosis. Chemotherapy is the main therapeutic option available for these patients, but it is usually associated with short overall survival. Case Presentation: We report the case of a patient diagnosed with metastatic triple-negative breast cancer with an impressive long-lasting tumor response and long-term survival after pembrolizumab monotherapy. Conclusion: Immunotherapy is emerging as a promising treatment for some breast cancer patients. Nevertheless, monotherapy studies have shown a very limited activity. Nowadays, there is no good predictor biomarker. Further investigations are needed to identify the subgroup of patients who can benefit from checkpoint inhibitor treatment. [ABSTRACT FROM AUTHOR]

Background: Obesity in children and adolescents has increased alarmingly, placing them at a higher risk for impaired glucose tolerance and type 2 diabetes. The prevalence of vitamin D deficiency has increased as well. Vitamin D is critical for glucose homeostasis and insulin secretion. Studies on adults have reported an inverse association between vitamin D levels and insulin resistance (IR), but the results in children are inconsistent. The aim of our study was to determine the association between IR and serum vitamin D levels in obese Mexican children and adolescents. Methods: A cross-sectional study was performed on 227 children and adolescents between 6 and 19 years of age. Obesity was diagnosed through body mass index (BMI) for age, according to the World Health Organization (WHO) criteria (2007). 25-Hydroxyvitamin D (25[OH]D) was measured using an immunoassay technique and the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the Matthews equation. Student's t-test was carried out. Results: The mean serum 25(OH)D level was 35.80 ng/mL, and 55.1% of the subjects had levels classified as sufficient, 33.5% as insufficient, and 11.5% as deficient. The mean level of HOMA-IR was 3.16, and 70% of the subjects were diagnosed with IR. Fasting insulin levels and HOMA-IR were significantly different in adolescents with hypovitaminosis, compared with adolescents in the vitamin D sufficiency group (p = 0.01 and p = 0.03, respectively). Conclusions: The insulin levels and HOMA-IR were higher in adolescents with hypovitaminosis. The girls presented higher levels of insulin and HOMA-IR than the boys. [ABSTRACT FROM AUTHOR]

Copyright of e-Revista Internacional de la Protección Social is the property of e-Revista Internacional de la Proteccion Social and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Key message: An original RNA-seq mapping strategy, validated with chromosome engineering and physical mapping, identifies candidate genes for fertility restoration in the 6HchS chromosome of Hordeum chilense in the wheat msH1 system. Cytoplasmic male sterility (CMS) is a valuable trait for hybrid seed production. The msH1 CMS system in common wheat results from the incompatibility between the nuclear genome of wheat and the cytoplasm of the wild barley Hordeum chilense. This work aims to identify H. chilense candidate genes for fertility restoration in the msH1 system with a multidisciplinary strategy based on chromosome engineering, differential expression analysis and genome mapping. Alloplasmic isogenic wheat lines differing for fertility, associated with the presence of an acrocentric chromosome Hchac resulting from the rearrangement of the short arms of H. chilense chromosomes 1Hch and 6Hch, were used for transcriptome sequencing. Two novel RNA-seq mapping approaches were designed and compared to identify differentially expressed genes of H. chilense associated with male fertility restoration. Minichromosomes (Hchmi), new smaller reorganizations of the Hchac also restoring fertility, were obtained and used to validate the candidate genes. This strategy was successful identifying a putative restorer-of-fertility region on 6HchS, with six candidate genes, including the ortholog of the barley restorer gene Rfm1. Additionally, transcriptomics gave preliminary insights on sterility and restoration networks showing the importance of energy supply, stress, protein metabolism and RNA processing. [ABSTRACT FROM AUTHOR]

The effect of concentrates based on unconventional ingredients on the intramuscular fatty acid profile of lambs was evaluated. A total of 105 lambs were assigned to one of three treatments: Control (concentrate based on cereals and soybean meal like commercial concentrates), Camelina (where 50% of crude protein from soybean meal was replaced by camelina meal), and Fibrous (concentrate based on several fibrous by-products, such as soybean hulls and wheat bran, as well as camelina meal and other unconventional ingredients). After 42 days in feedlot, the lambs were sacrificed, and the fatty acid profile of intramuscular fat was determined by gas chromatography. Total meat lipids (1.25 g/100 g of meat) were not modified by the treatments. The Camelina treatment showed minor effects on the intramuscular fat composition. In contrast, the Fibrous treatment showed the highest contents of trans -11 18 : 1 (vaccenic acid), cis -9 trans -11 18 : 2 (rumenic acid) and α-linolenic acid. Thus, the non-traditional Fibrous concentrate assayed in the present study might improve the meat quality of light lambs from a nutritional point of view. Fatty acid profile plays an important role in meat quality, as it is related to differences in organoleptic attributes, and meat nutritional value. The aim of this study was to evaluate the effects of feeding concentrates that included alternative ingredients on the intramuscular fatty acid profile of feedlot lambs. The concentrate rich in fibrous by-products might improve the fatty acid profile of meat fat from a nutritional point of view. [ABSTRACT FROM AUTHOR]

Copyright of Liño: Revista Annual de Historia del Arte is the property of Universidad de Oviedo, Servicio de Publicaciones and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

International non-profit organizations (INGOs) were traditionally established to facilitate dialogue and bridge cultures. In order for INGOs to successfully carry out their objectives, global activists must work together in a culturally sensitive and responsible manner. The current article examines a volunteer training model that was designed to promote meaningful interactions between binational volunteers. The training, based on a Spanish-immersion and homestay experience, was piloted among volunteers at an INGO on the Mexico-US border. Results suggest that the immersion training model allowed volunteers to reassess and ultimately strengthen their relationships with their international counterparts while developing intercultural citizenship skills. [ABSTRACT FROM AUTHOR]

As the peripheral sympathoadrenal axis is tightly controlled by the cortex via hypothalamus and brain stem, the central pathological features of Hunting's disease, (HD) that is, deposition of mutated huntingtin and synaptic dysfunctions, could also be expressed in adrenal chromaffin cells. To test this hypothesis we here present a thorough investigation on the pathological and functional changes undergone by chromaffin cells (CCs) from 2‐month (2 m) to 7‐month (7 m) aged wild‐type (WT) and R6/1 mouse model of Huntington's disease (HD), stimulated with acetylcholine (ACh) or high [K+] (K+). In order to do this, we used different techniques such as inmunohistochemistry, patch‐clamp, and amperometric recording. With respect to WT cells, some of the changes next summarized were already observed in HD mice at a pre‐disease stage (2 m); however, they were more pronounced at 7 m when motor deficits were clearly established, as follows: (i) huntingtin over‐expression as nuclear aggregates in CCs; (ii) smaller CC size with decreased dopamine β‐hydroxylase expression, indicating lesser number of chromaffin secretory vesicles; (iii) reduced adrenal tissue catecholamine content; (iv) reduced Na+ currents with (v) membrane hyperpolarization and reduced ACh‐evoked action potentials; (v) reduced [Ca2+]c transients with faster Ca2+ clearance; (vi) diminished quantal secretion with smaller vesicle quantal size; (vii) faster kinetics of the exocytotic fusion pore, pore expansion, and closure. On the basis of these data, the hypothesis is here raised in the sense that nuclear deposition of mutated huntingtin in adrenal CCs of R6/1 mice could be primarily responsible for poorer Na+ channel expression and function, giving rise to profound depression of cell excitability, altered Ca2+ handling and exocytosis. Open Practices: This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/. Cover Image for this issue: doi: 10.1111/jnc.14201. Peripheral sympatho‐adrenal axis has been found to be altered in some neurodegenerative diseases. In this study we have found that adrenal chromaffin cells of the R6/1 mouse model of Huntington's disease (HD) exhibits large mutated huntingtin (mHtt) nuclear inclusions and notable decrease in Na+ current (1), profound diminution of cell excitability (2), and reduction of the release of catecholamines adrenaline and noradrenaline through a disturbed exocytotic fusion pore (3, 4). As the sympatho‐adrenal axis plays an essential role in adaptation to stress through the fight‐or‐flight response, this study suggests that such response could be sharply deteriorated in HD patients. Cover Image for this issue: doi: 10.1111/jnc.14201. Open Science: This manuscript was awarded with the Open Materials Badge. For more information see: https://cos.io/our-services/open-science-badges/ [ABSTRACT FROM AUTHOR]

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Soil treatments with Metarhizium brunneum EAMa 01/58-Su strain conducted in both Northern and Southern Spain reduced the olive fly (Bactrocera oleae) population density emerging from the soil during spring up to 70% in treated plots compared with controls. A model to determine the influence of rainfall on the conidial wash into different soil types was developed, with most of the conidia retained at the first 5 cm, regardless of soil type, with relative percentages of conidia recovered ranging between 56 and 95%. Furthermore, the possible effect of UV-B exposure time on the pathogenicity of this strain against B. oleae adults coming from surviving preimaginals and carrying conidia from the soil at adult emergence was also evaluated. The UV-B irradiance has no significant effect on M. brunneum EAMa 01/58-Su pathogenicity with B. oleae adult mortalities of 93, 90, 79, and 77% after 0, 2, 4, and 6 of UV-B irradiance exposure, respectively. In a next step for the use of these M. brunneum EAMa 01/58-Sun soil treatments within a B. oleae IPM strategy, its possible effect of on the B. oleae cosmopolitan parasitoid Psyttalia concolor, its compatibility with the herbicide oxyfluorfen 24% commonly used in olive orchards and the possible presence of the fungus in the olive oil resulting from olives previously placed in contact with the fungus were investigated. Only the highest conidial concentration (1 x 108 conidia ml-) caused significant P. concolor adult mortality (22%) with enduing mycosis in 13% of the cadavers. There were no fungal propagules in olive oil samples resulting from olives previously contaminated by EAMa 01/58-Su conidia. Finally, the strain was demonstrated to be compatible with herbicide since the soil application of the fungus reduced the B. oleae population density up to 50% even when it was mixed with the herbicide in the same tank. The fungal inoculum reached basal levels 4 months after treatments (1.6 x 10³ conidia g soil -1). These results reveal both the efficacy and environmental and food safety of this B. oleae control method, protecting olive groves and improving olive oil quality without negative effects on the natural enemy P. concolor. [ABSTRACT FROM AUTHOR]

Copyright of Ars Longa is the property of Ars Longa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Espacio, Tiempo y Forma. Serie VII, Historia del Arte is the property of Editorial UNED and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Increasing levels of Heracleum persicum (golpar) in drinking water were studied in broilers. Two hundred and forty-one-day-old male chickens were allocated to one of six treatments: control, without added phytogenics nor probiotics in drinking water, and probiotics at recommended manufacturer's level (P) or 1.0, 1.5, 2.0, and 2.5 ml/l of golpar extract solution (G1, G1.5, G2, and G2.5 treatments, respectively) in drinking water. As a result of this study, no linear or quadratic trends in the feed intake (FI) and feed conversion rate (FCR) due to golpar supplementation were found. Body weight gain, final body weight, and relative carcass weight showed a positive linear response with increasing levels of golpar supplementation. Neither golpar nor probiotics had effects on the percentages of edible parts of the carcass. Golpar supplementation levels caused a linear negative response of the albumin content in blood plasma, whereas both abdominal fat as percentage of carcass weight and uric acid levels in blood plasma linearly increased. The effects on Ig responses were only observed at 42 days of age and were similar in probiotics and the highest level of golpar supplementation. Based on our results, both probiotics and golpar supplementation could improve broiler performance and immune function. [ABSTRACT FROM AUTHOR]

Key points Upon repeated application of short ACh pulses to C57BL6J mouse chromaffin cells, the amperometrically monitored secretory responses promptly decayed to a steady-state level of around 25% of the initial response. A subsequent K+ pulse, however, overcame such decay. These data suggest that mouse chromaffin cells have a ready release-vesicle pool that is selectively recruited by the physiological neurotransmitter ACh., The ACh-sensitive vesicle pool is refilled and maintained by the rate of Ca2+ delivery from mitochondria to the cytosol, through the mitochondrial Na+/Ca2+ exchanger (mNCX). ITH12662, a novel blocker of the mNCX, prevented the decay of secretion elicited by ACh pulses and delayed the rate of [Ca2+]c clearance., This regulatory pathway may be physiologically relevant in situations of prolonged stressful conflicts where a sustained catecholamine release is regulated by mitochondrial Ca2+ circulation through the mNCX, which couples respiration and ATP synthesis to long-term stimulation of chromaffin cells by endogenously released ACh., Abstract Using caged-Ca2+ photorelease or paired depolarising pulses in voltage-clamped chromaffin cells (CCs), various pools of secretory vesicles with different readiness to undergo exocytosis have been identified. Whether these pools are present in unclamped CCs challenged with ACh, the physiological neurotransmitter at the splanchnic nerve-CC synapse, is unknown. We have explored here whether an ACh-sensitive ready-release vesicle pool (ASP) is present in C57BL6J mouse chromaffin cells (MCCs). Single cells were fast perfused with a Tyrode solution at 37°C, and challenged with 12 sequential ACh pulses (100 μ m, 2 s, every 30 s) plus a K+ pulse given at the end (75 m m K+). After the first 2-3 ACh pulses the amperometrically monitored secretory responses promptly decayed to a steady-state level of around 25% of the initial response. The last K+ pulse, however, overcame such decay. Repeated ACh pulses to voltage-clamped cells elicited non-desensitising nicotinic currents. Also, the [Ca2+]c transients elicited by repeated ACh pulses that were superimposed on a stable baseline elevation did not undergo decay. The novel blocker of the mitochondrial Na+/Ca2+ exchanger (mNCX) ITH12662 prevented the decay of secretion elicited by ACh pulses and delayed the rate of [Ca2+]c clearance. The experiments are compatible with the idea that C57BL6J MCCs have an ASP vesicle pool that is selectively recruited by the physiological neurotransmitter ACh and is regulated by the rate of Ca2+ delivery from mitochondria to the cytosol, through the mNCX. [ABSTRACT FROM AUTHOR]

Adrenal chromaffin cells (CCs) have been used extensively in studies aimed at revealing the intricacies of the Ca2+- dependent early and late steps of regulated exocytosis. They have also served as invaluable models to study the kinetics of single-vesicle exocytotic events to infer the characteristics of opening and closing of the exocytotic fusion pore. We have here tested the hypothesis that stimulation at room temperature of CCs from mice C57BL/6 with physiological acetylcholine (ACh) and with other secretagogues (dimethylphenylpiperazinium, high K+, muscarine, histamine, caffeine), alone or in combination, could trigger amperometric spike events with different kinetics. We found that mean secretory spike events in CCs stimulated with ACh had a fast rise rate of 25 pA/ms and a rapid decay time of 6.2 ms, with a small quantal size (0.31 pC). Surprisingly, these parameters considerably differed from those found in CCs stimulated with all other secretagogues that triggered secretory responses with spike events having smaller rise rates, longer decay times and higher quantal sizes. ACh spikes were unaltered by atropine but mitochondrial protonophore carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone markedly slowed down the rate rise and decay time, and augmented the quantal size of mean secretory events. We conclude that the physiological neurotransmitter ACh triggers a fast and efficient exocytotic response that cannot be mimicked by other secretagogues; such response is regulated by the mitochondrial circulation of calcium ions. [ABSTRACT FROM AUTHOR]

Copyright of BiD is the property of Facultat de Biblioteconomia i Documentacio, Universitat de Barcelona and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)