26 results on '"Pontén, Eva"'
Search Results
2. Expert consensus on the surgical evaluation and management of upper extremity spasticity in adults.
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Crowe, Christopher S., Pino, Paula A., Rhee, Peter C., Boyce, Dean, Fridén, Jan, Horwitz, Maxim, Lam, Wee Leon, Leclercq, Caroline, Luria, Shai, McArthur, Paul, Sturbois-Nachef, Nadine, Obdeijn, Miryam, Panciera, Paolo, Pickard, Simon, Pontén, Eva, Rajaratnam, Vaikunthan, and Sabapathy, Raja
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FORELIMB ,SPASTICITY ,STROKE ,CEREBRAL palsy ,MOTOR neurons ,DIAGNOSIS methods - Abstract
In the last decade there has been incredible interest and advancement in the surgical care of adult patients with upper motor neuron (UMN) injuries. Spasticity represents a prevalent and debilitating feature of UMN syndrome, which can result from cerebral palsy, spinal cord injury, cerebrovascular accident and traumatic or anoxic brain injury. While several diagnostic tools and management strategies have been described for upper limb spasticity, evidence-based practice guidelines do not currently exist due to low patient volume and a paucity of surgeons routinely performing surgeries in UMN syndrome patients. As such, expert consensus may help provide guidance for patients, therapists and clinicians alike. In this article an expert panel was assembled, and the Delphi method was utilized to present diagnostic considerations, define operative indications, discuss surgical treatment modalities and encourage a standard set of outcome measures for patients with upper extremity spasticity. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Time-matched accelerometers on limbs and waist in children with CP give new insights into real-life activities after botulinum toxin treatment: A proof of concept study.
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Gantelius, Stefan, Vikerfors, Sandra, Edqvist, Josefin Jansson, von Walden, Ferdinand, Hagströmer, Maria, and Pontén, Eva
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BOTULINUM toxin ,HOME environment ,SCHOOL environment ,SCIENTIFIC observation ,CONFIDENCE intervals ,TIME ,RESEARCH methodology ,ACCELEROMETERS ,WEARABLE technology ,PRE-tests & post-tests ,BODY movement ,RESEARCH funding ,CEREBRAL palsy ,CHILDREN - Abstract
PURPOSE: This study aimed to explore the feasibility of using time-matched uniaxial accelerometers for measuring movement in daily life in children with cerebral palsy (CP) before and after botulinum toxin injections. METHODS: This observational study of clinical care with a pre-post design was set in the home and school environment. Participants included eleven children (4–13 years of age) with CP (GMFCS I-III). The children wore uniaxial accelerometers (ActiGraph, model GT1M) for 4 days on both wrists, the right ankle and around the waist before, 3 weeks and 3 months after BoNT-A injections in the legs. Five children also got BoNT-A in the most affected arm. All injections were given according to clinical indications and routine. The accelerometers were all time-matched to define ambulation, arm swing, voluntary activity of arms, and bimanual activity. The feasibility of wearing accelerometers with this setup was evaluated. A linear mixed model was used for analysis of the percentage time and at which intensity the different activities were performed. The confidence interval demonstrated any difference between the dominant and non-dominant arm. RESULTS: Time-matching of accelerometers placed on both wrists, the waist, and one ankle is a feasible method of registering ambulation, arm swing during gait, and arm movements while not ambulating. Before injections, the children spent 5.6% of their time ambulating. This value declined to 3.9% at 3 months. Contrary to clinical goals, arm movement did not increase after injecting the most affected arm with BoNT-A, however, injections may have decreased mirror movements, which are often bothersome for the child. CONCLUSION: A time-matched 4-accelerometer set-up is feasible in children with cerebral palsy. A future study including time-matched multi-axial accelerometers on all four limbs, could provide important information on the effect of BoNT-A in daily life. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise.
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Vechetti, Ivan J., Norrbom, Jessica, Alkner, Björn, Hjalmarsson, Emma, Palmcrantz, Alexandra, Pontén, Eva, Pingel, Jessica, von Walden, Ferdinand, and Fernandez-Gonzalo, Rodrigo
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AEROBIC exercises ,EXTRACELLULAR vesicles ,CEREBRAL palsy ,MICRORNA ,EXTRACELLULAR matrix - Abstract
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs. Nine adult individuals with CP performed a single exercise bout consisting of 45 min of Frame Running, and TD participants completed either 45min of cycling (n = 10; TD EX) or were enrolled as controls with no exercise (n = 10; TD CON). Blood was drawn before and 30min after exercise and analyzed for EV concentration, size, and microRNA content. The size of EVs was similar in CP vs. TD, and exercise had no effect. Individuals with CP had an overall lower concentration (~25%, p < 0.05) of EVs. At baseline, let-7a, let-7b and let-7e were downregulated in individuals with CP compared to TD (p < 0.05), while miR-100 expression was higher, and miR-877 and miR-4433 lower in CP compared to TD after exercise (p < 0.05). Interestingly, miR-486 was upregulated ~2-fold in the EVs of CP vs. TD both at baseline and after exercise. We then performed an in silico analysis of miR-486 targets and identified the satellite cell stemness factor Pax7 as a target of miR-486. C2C12 myoblasts were cultured with amiR-486 mimetic and RNA-sequencing was performed. Gene enrichment analysis revealed that several genes involved in sarcomerogenesis and extracellular matrix (ECM) were downregulated. Our data suggest that circulating miR-486 transported by EVs is elevated in individuals with CP and that miR-486 alters the transcriptome of myoblasts affecting both ECM- and sarcomerogenesis-related genes, providing a link to the skeletal muscle alterations observed in individuals with CP. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Physiological Response to the 6-Minute Frame Running Test in Children and Adults With Cerebral Palsy.
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Edelman Bos, Arnoud M. M., Hjalmarsson, Emma, Dallmeijer, Annet J., Fernandez-Gonzalo, Rodrigo, Buizer, Annemieke I., Pingel, Jessica, Pontén, Eva, von Walden, Ferdinand, and van Schie, Petra E. M.
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- 2022
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6. Editorial: Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease.
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Yucesoy, Can A., Pontén, Eva, Valero-Cuevas, Francisco J., Smeulders, Mark, and Simms, Ciaran Knut
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SPASTICITY ,EXTRACELLULAR matrix ,DIFFUSION tensor imaging ,MUSCULOSKELETAL system ,NERVOUS system - Abstract
Due to a highly variable distribution of intramuscular collagen content within muscle, the amount collagen content itself does not relate to the actual passive muscle properties during mechanical testing as was shown in mouse hind limb muscles (Binder-Markey et al.). Keywords: muscle mechanics; extracellular matrix; connective tissue; neuromusculoskeletal interaction; adaptation; pathology; force production - transmission phenomena EN muscle mechanics extracellular matrix connective tissue neuromusculoskeletal interaction adaptation pathology force production - transmission phenomena 1 6 6 12/08/21 20211206 NES 211206 There is a growing emphasis on the importance of muscle extracellular matrix on muscular mechanics and specifically on the effects of the interaction of the extracellular matrix (ECM) and the contractile apparatus. An experimental assessment using multi-photon excitation microscopy in mouse tibialis anterior muscle surgically dissected from the tibia and surrounding muscles showed that in isometrically activated muscle the sarcomeres re-organize their lengths into a more uniform pattern over time, whereas in the passive state their length non-uniformity remained the same (Moo and Herzog). They demonstrate how a passively lengthened muscle can also have shortened parts and how an isometric contracting muscle can also have lengthened parts along the muscle fascicles. [Extracted from the article]
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- 2021
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7. Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy.
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von Walden, Ferdinand, Vechetti, Ivan J, Englund, Davis, Figueiredo, Vandré C, Fernandez‐Gonzalo, Rodrigo, Murach, Kevin, Pingel, Jessica, Mccarthy, John J, Stål, Per, and Pontén, Eva
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CHILDREN with cerebral palsy ,TYPE 2 diabetes ,MITOCHONDRIAL DNA ,SKELETAL muscle ,SPECIFIC language impairment in children ,PGC-1 protein ,AEROBIC capacity - Abstract
Skeletal muscle in individuals with CP also contains lower amounts of mtDNA, potentially indicating fewer mitochondria in CP skeletal muscle compared with typically developing muscle. We compared skeletal muscle samples from children with cerebral palsy (CP) and typically developing children and observed evidence of reduced mtDNA and OXPHOS protein content in CP skeletal muscle, indicating reduced mitochondrial abundance. Cerebral palsy (CP) muscle contains fewer energy-generating organelles than typically developing muscle. [Extracted from the article]
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- 2021
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8. Current concepts in diagnosis and management of common upper limb nerve injuries in children.
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Catena, Nunzio, Di Gennaro, Giovanni Luigi, Jester, Andrea, Martínez-Alvarez, Sergio, Pontén, Eva, Soldado, Francisco, Steiger, Christina, Jiahui Choong, Zarantonello, Paola, and Farr, Sebastian
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SOFT tissue injuries ,PERIPHERAL nervous system ,NERVES ,PATIENT compliance - Abstract
Peripheral nerve injuries (PNI) of the upper limb are a common event in the paediatric population, following both fractures and soft tissues injuries. Open injuries should in theory be easier to identify and the repair of injured structures performed as soon as possible in order to obtain a satisfying outcome. Conversely, due to the reduced compliance of younger children during clinical assessment, the diagnosis of a closed nerve injury may sometimes be delayed. As the compliance of patients is influenced by pain, anxiety and stress, the execution of the clinical manoeuvres intended to identify a loss of motor function or sensibility, can be impaired. Although the majority of PNI are neuroapraxias resulting in spontaneous recovery, there are open questions regarding certain aspects of closed PNI, e.g. when to ask for electrophysiological exams, when and how long to wait for a spontaneous recovery and when a surgical approach becomes mandatory. The aim of the article is therefore to analyse the main aspects of the different closed PNI of the upper limb in order to provide recommendations for timely and correct management, and to determine differences in the PNI treatment between children and adults. [ABSTRACT FROM AUTHOR]
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- 2021
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9. COMPARATIVE ANALYSIS OF POWER, WORK AND MUSCLE ACTIVATION DURING WEIGHT-STACK AND ISO-INERTIAL FLYWHEEL RESISTANCE EXERCISE IN YOUNG ADULTS WITH CEREBRAL PALSY.
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VON WALDEN, Ferdinand, HJALMARSSON, Emma, REIMERINGER, Mikael, KVIST, Ola, RAFFALT, Peter C., PONTÉN, Eva, and FERNANDEZ-GONZALO, Rodrigo
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- 2020
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10. RaceRunning training improves stamina and promotes skeletal muscle hypertrophy in young individuals with cerebral palsy.
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Hjalmarsson, Emma, Fernandez-Gonzalo, Rodrigo, Lidbeck, Cecilia, Palmcrantz, Alexandra, Jia, Angel, Kvist, Ola, Pontén, Eva, and von Walden, Ferdinand
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SKELETAL muscle ,MUSCLE growth ,CEREBRAL palsy ,RATE of perceived exertion ,VASTUS lateralis - Abstract
Background: Individuals with cerebral palsy (CP) are less physically active, spend more time sedentary and have lower cardiorespiratory endurance as compared to typically developed individuals. RaceRunning enables high-intensity exercise in individuals with CP with limited or no walking ability, using a three-wheeled running bike with a saddle and a chest plate for support, but no pedals. Training adaptations using this type of exercise are unknown.Methods: Fifteen adolescents/young adults (mean age 16, range 9-29, 7 females/8 males) with CP completed 12 weeks, two sessions/week, of RaceRunning training. Measurements of cardiorespiratory endurance (6-min RaceRunning test (6-MRT), average and maximum heart rate, rate of perceived exertion using the Borg scale (Borg-RPE)), skeletal muscle thickness (ultrasound) of the thigh (vastus lateralis and intermedius muscles) and lower leg (medial gastrocnemius muscle) and passive range of motion (pROM) of hip, knee and ankle were collected before and after the training period.Results: Cardiorespiratory endurance increased on average 34% (6-MRT distance; pre 576 ± 320 m vs. post 723 ± 368 m, p < 0.001). Average and maximum heart rate and Borg-RPE during the 6-MRT did not differ pre vs. post training. Thickness of the medial gastrocnemius muscle increased 9% in response to training (p < 0.05) on the more-affected side. Passive hip flexion increased (p < 0.05) on the less-affected side and ankle dorsiflexion decreased (p < 0.05) on the more affected side after 12 weeks of RaceRunning training.Conclusions: These results support the efficacy of RaceRunning as a powerful and effective training modality in individuals with CP, promoting both cardiorespiratory and peripheral adaptations. [ABSTRACT FROM AUTHOR]- Published
- 2020
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11. International multidisciplinary collaboration toward an annotated definition of arthrogryposis multiplex congenita.
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Dahan‐Oliel, Noémi, Cachecho, Sarah, Barnes, Douglas, Bedard, Tanya, Davison, Ann M., Dieterich, Klaus, Donohoe, Maureen, Fąfara, Alicja, Hamdy, Reggie, Hjartarson, Helgi T., S. Hoffman, Naimisha, Kimber, Eva, Komolkin, Igor, Lester, Ruth, Pontén, Eva, Bosse, Harold J. P., and Hall, Judith G.
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- 2019
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12. Outcome of hand surgery in children with spasticity - a 9-year follow-up study.
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Pontén, Eva, von Walden, Ferdinand, Lenke-Ekholm, Catarina, Zethraeus, Britt-Marie, and Eliasson, Ann-Christin
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- 2019
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13. Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro-inflammatory gene expression, and reduced rRNA synthesis.
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Von Walden, Ferdinand, Gantelius, Stefan, Liu, Chang, Borgström, Hanna, Björk, Lars, Gremark, Ola, Stål, Per, Nader, Gustavo A., and PontéN, Eva
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Introduction: Children with cerebral palsy (CP) and acquired brain injury (ABI) commonly develop muscle contractures with advancing age. An underlying growth defect contributing to skeletal muscle contracture formation in CP/ABI has been suggested.Methods: The biceps muscles of children and adolescents with CP/ABI (n = 20) and typically developing controls (n = 10) were investigated. We used immunohistochemistry, quantitative real-time polymerase chain reaction, and Western blotting to assess gene expression relevant to growth and size homeostasis.Results: Classical pro-inflammatory cytokines and genes involved in extracellular matrix (ECM) production were elevated in skeletal muscle of children with CP/ABI. Intramuscular collagen content was increased and satellite cell number decreased and this was associated with reduced levels of RNA polymerase I transcription factors, 45s pre-rRNA and 28S rRNA.Discussion: The present study provides novel data suggesting a role for pro-inflammatory cytokines and reduced ribosomal production in the development/maintenance of muscle contractures, possibly underlying stunted growth and perimysial ECM expansion. Muscle Nerve 58: 277-285, 2018. [ABSTRACT FROM AUTHOR]- Published
- 2018
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14. Influence of muscle groups' activation on proximal femoral growth tendency.
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Yadav, Priti, Shefelbine, Sandra, Pontén, Eva, and Gutierrez-Farewik, Elena
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HIP joint ,BONE growth ,BIOMECHANICS ,GAIT in humans ,COMPUTER simulation ,FINITE element method ,MAGNETIC resonance imaging - Abstract
Muscle and joint contact force influence stresses at the proximal growth plate of the femur and thus bone growth, affecting the neck shaft angle (NSA) and femoral anteversion (FA). This study aims to illustrate how different muscle groups' activation during gait affects NSA and FA development in able-bodied children. Subject-specific femur models were developed for three able-bodied children (ages 6, 7, and 11 years) using magnetic resonance images. Contributions of different muscle groups-hip flexors, hip extensors, hip adductors, hip abductors, and knee extensors-to overall hip contact force were computed. Specific growth rate for the growth plate was computed, and the growth was simulated in the principal stress direction at each element in the growth front. The predicted growth indicated decreased NSA and FA (of about $$0.1 {^{\circ }}$$ over a four-month period) for able-bodied children. Hip abductors contributed the most, and hip adductors, the least, to growth rate. All muscles groups contributed to a decrease in predicted NSA ( $$\sim $$ 0.01 $${^{\circ }}$$ -0.04 $${^{\circ }})$$ and FA ( $$\sim $$ 0.004 $${^{\circ }}$$ - $$0.2{^{\circ }}$$ ), except hip extensors and hip adductors, which showed a tendency to increase the FA ( $$\sim $$ 0.004 $${^{\circ }}$$ - $$0.02{^{\circ }}$$ ). Understanding influences of different muscle groups on long bone growth tendency can help in treatment planning for growing children with affected gait. [ABSTRACT FROM AUTHOR]
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- 2017
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15. Forearm Flexor Muscles in Children with Cerebral Palsy Are Weak, Thin and Stiff.
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von Walden, Ferdinand, Jalaleddini, Kian, Evertsson, Björn, Friberg, Johanna, Valero-Cuevas, Francisco J., and Pontén, Eva
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CEREBRAL palsy ,SKELETAL muscle ,BIOMECHANICS ,WRIST ,BRAIN damage - Abstract
Children with cerebral palsy (CP) often develop reduced passive range of motion with age. The determining factor underlying this process is believed to be progressive development of contracture in skeletal muscle that likely changes the biomechanics of the joints. Consequently, to identify the underlying mechanisms, we modeled the mechanical characteristics of the forearm flexors acting across the wrist joint. We investigated skeletal muscle strength (Grippit®) and passive stiffness and viscosity of the forearm flexors in 15 typically developing (TD) children (10 boys/5 girls, mean age 12 years, range 8-18 yrs) and nine children with CP Nine children (6 boys/3 girls, mean age 11 ± 3 years (yrs), range 7-15 yrs) using the NeuroFlexor® apparatus. The muscle stiffness we estimate and report is the instantaneous mechanical response of the tissue that is independent of reflex activity. Furthermore, we assessed cross-sectional area of the flexor carpi radialis (FCR) muscle using ultrasound. Age and body weight did not differ significantly between the two groups. Children with CP had a significantly weaker (-65%, p < 0.01) grip and had smaller cross-sectional area (-43%, p < 0.01) of the FCR muscle. Passive stiffness of the forearm muscles in children with CP was increased 2-fold (p < 0.05) whereas viscosity did not differ significantly between CP and TD children. FCR cross-sectional area correlated to age (R² = 0.58, p < 0.01), body weight (R² = 0.92, p < 0.0001) and grip strength (R² = 0.82, p < 0.0001) in TD children but only to grip strength (R² = 0.60, p < 0.05) in children with CP. We conclude that children with CP have weaker, thinner, and stiffer forearm flexors as compared to typically developing children. [ABSTRACT FROM AUTHOR]
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- 2017
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16. Management of the knees in arthrogryposis.
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Pontén, Eva
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Arthrogryposis is defined as limited range of motion in three or more joints in two or more body parts. This article will describe treatment options for the arthrogrypotic knee. In all types of arthrogryposis, and in both extension and flexion deformities, very early treatment is favorable. Just after birth, traction and mobilization followed by serial casting could often greatly improve the range of motion. In the hyperextended knee, surgical lengthening of the extensor apparatus may be needed. Flexion deformities could be improved with temporary physeal arrest of the anterior distal femur by fixing two-hole plates over the physis on both sides of patella. The plates will result in a constrained growth of the anterior physis, and thus a very slow extension of the knee, which will give the nerves and vessels time to adjust. Pterygium, webbing of the knee joint, is a special subgroup that in selected mild cases could be treated with extensive surgical release of the webbing and orthotics. Arthrogrypotic knees can be treated with early reduction and maintenance with orthotics. [ABSTRACT FROM AUTHOR]
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- 2015
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17. Orthopaedic Management of CP/Myelomeningocele - Upper Limb.
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Pontén, Eva
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- 2014
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18. Higher Expression of Myosin Heavy Chain IIx in Wrist Flexors in Cerebral Palsy.
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Gantelius, Stefan, Hedström, Yvette, and Pontén, Eva
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PEOPLE with cerebral palsy ,CEREBRAL palsy ,MYOSIN ,HAND surgery ,BRAIN injuries ,MUSCLES - Abstract
Background: Children with cerebral palsy (CP) use their paretic arm less than normal but have a relative overactivity of wrist flexors, causing an impairing flexed position of the wrist. Voluntary use of a muscle downregulates myosin heavy chain (MyHC) IIx, but it is unclear whether the relative overactivity of wrist flexors and extensors in children with CP affects MyHC expression compared to normal subjects. Questions/purposes: We therefore asked whether MyHC expression composition differs in wrist flexors compared to extensors in children with CP and in controls and whether it is related to clinical findings. Methods: We took muscle biopsies from wrist flexors and extensors during hand surgery in children with CP (n = 9) and during open reduction of forearm fractures in control children (n = 5). The expression of the MyHC I, IIa, and IIx isoforms were determined on silver-stained 6% SDS-PAGE. Results: CP flexors showed a higher proportion of MyHC IIx (40%) than control flexors (16%) and CP extensors (20%). MyHC IIa isoform proportion was lower in CP flexors (27%) than in control flexors (46%) and in CP extensors (45%). MyHC I expression was lower in CP (36%) than in controls (46%) for wrist extensors only. Conclusions: Both the brain injury in CP and the different demands on flexors and extensors affect the expression of MyHCs. The higher amount of MyHC IIx in CP could be caused by a decreased voluntary use of the hemiplegic arm. Clinical Relevance: More information on the structural difference between flexors and extensors in normal and spastic muscle could improve the understanding of strain of wrist extensors and possibly the development of flexion contractures in CP. [ABSTRACT FROM AUTHOR]
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- 2012
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19. Feasibility of a Day-Camp Model of Modified Constraint-Induced Movement Therapy With and Without Botulinum Toxin A Injection for Children With Hemiplegia.
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Eliasson, Ann-Christin, Shaw, Karin, Pontén, Eva, Boyd, Roslyn, and Krumlinde-Sundholm, Lena
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The objective of the study was to investigate the feasibility of modified constraint-induced (CI) therapy provided in a 2-week day-camp model with and without intramuscular botulinum toxin type A (BoNT-A) injections for children with congenital cerebral palsy. Sixteen children with congenital hemiplegia, Manual Ability Classification System (MACS) level I and II, aged 8-17 years, participated in a CI therapy day camp; of whom five participants (aged 11-16 years) received intramuscular BoNT-A prior to CI therapy. Assessments were conducted 4 months and 2 weeks before (baselines 1 and 2), immediately after, and 6 months after the day camp. For the children who received BoNT-A, no statistical analyses were conducted due to the small size of the sample. In this group, consistent improvement was only found according to the Melbourne Unilateral Limb Assessment. The children who received only the CI therapy demonstrated improvements in the Jebsen-Taylor Hand Function Test ( p =. 04) at posttest, but improvements were not sustained at 6-month follow-up. No significant improvement was obtained for the Melbourne Assessment or the Assisting Hand Assessment. Children in both groups improved on specially trained tasks: frisbee golf, stacking blocks, and in-hand manipulation. Feedback from the participants suggests that the day-camp model is a feasible intervention following intramuscular BoNT-A injections. The results suggest that children with congenital hemiplegia with varying severity of impairment in hand function may benefit from CI therapy, but not every child demonstrates improvements in hand function. The characteristics of children who respond the best to CI therapy are not clear. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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20. Intraoperative muscle measurements reveal a relationship between contracture formation and muscle remodeling.
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Pontén, Eva, Gantelius, Stefan, and Lieber, Richard L.
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Children with cerebral palsy often have spasticity of both the extensors and flexors, but how and why a flexion contracture of the wrist will develop during growth is not thoroughly understood. In order to understand the muscle adaptations that occur during contracture formation, the relationship between intraoperative sarcomere length and the extent of contracture was measured in 23 children (average age, 14.3 ± 2.9 years) undergoing tendon transfers involving the flexor carpi ulnaris (FCU) or extensor carpi radialis brevis (ECRB) muscles. For both ECRB and FCU, sarcomere lengths measured intraoperatively were longer compared to sarcomere lengths predicted from a regression relationship obtained from 'control' patients with radial nerve injury ( P < 0.001). The most interesting aspect of the long FCU sarcomere lengths measured was that there was a highly significant correlation between the degree of contracture formation and intraoperative sarcomere length ( r = 0.5, P < 0.005). These data clearly show that greater contracture severity is associated with longer intraoperative FCU sarcomere length. No such correlation was observed for the ECRB. The data suggest that the clinical presentation of the contracture is related to degree of FCU, but not ECRB adaptation, to the central nervous system lesion. Muscle Nerve, 2007 [ABSTRACT FROM AUTHOR]
- Published
- 2007
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21. Spastic wrist flexors are more severely affected than wrist extensors in children with cerebral palsy.
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Pontén, Eva, Fridén, Jan, Thornell, Lars-Eric, and Lieber, Richard L
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Morphological properties of skeletal muscle were compared between wrist flexors and extensors within the same children (n = 8, six females, two males; age range 4 to 9y, median age 7 y) with wrist muscle imbalance secondary to spastic cerebral palsy (CP). Five patients had hemiplegic CP, two diplegic CP, and one patient had tetraplegic CP. Muscle biopsies were taken during either tendon transfer or tendon lengthening procedures. Analyses included distribution of muscle fibre types, fibre sizes, and expression of developmental myosins. Extensor fibre area was significantly greater than flexor fibre area for type 2A fibres and type 2B fibres but not for type 1 fibres. Coefficient of variation (CV) of fibre size for all three fibre types was greater for flexors compared with extensors. The greatest CV was observed for the type 2A fibres in flexors (39.5 [3.6%]). A wide variation was observed for expression of developmental myosin with the magnitude of the expression being greater, but not statistically significant, in flexors compared with extensors (5.4/mm2 vs 0.53/mm2). These data demonstrate that significant secondary myopathy of wrist flexor muscles results from CP. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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22. Summary of the 2nd international symposium on arthrogryposis, St. Petersburg, Russia, September 17-19, 2014.
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Hall, Judith G., Agranovich, Olga, Pontén, Eva, and van Bosse, Harold J. P.
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Enormous progress has been made in understanding the etiology and therapies for arthrogryposis (multiple congenital contractures). A 2nd International Symposium on Arthrogryposis was sponsored by the Turner Institute in St. Petersburg, Russia. Olga Agranovich, Head of the Arthrogryposis Department of the Turner Institute, organized this special meeting. Care providers from multiple disciplines from all over the world representing 18 nations attended. Participants included: Pediatric orthopedic specialists, rehabilitation physicians, occupational therapists, physical therapists, medical geneticists, neurologists, craniofacial physicians, psychologists, developmental biologists, as well as representatives from parent support groups. The 1st symposium established the need for a collaborative and interdisciplinary approach to the treatment of arthrogryposis, engagement of parent support organizations, and the aim for more research. The Second Symposium highlighted the continuing need for more research on various therapies, identification of different types of arthrogryposis, standardized descriptions of severity, development of new orthotics, improved prenatal diagnosis, and studying adult outcome. Major progress has been made on both upper and lower limb treatments. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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23. Contracture formation in the upper limb in cerebral palsy starts early.
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Pontén, Eva
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ARM ,CEREBRAL palsy ,BOTULINUM toxin ,EXTRACELLULAR matrix ,CONNECTIVE tissues ,CONTRACTURE (Pathology) ,EXPERIMENTAL design - Abstract
This commentary is on the original article by Hedberg‐Graff et al. on pages 204–211 of this issue. [ABSTRACT FROM AUTHOR]
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- 2019
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24. Summary of the 2nd International Symposium on Arthrogryposis, St. Petersburg, Russia, September 17-19, 2014.
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Hall, Judith G., Agranovich, Olga, Pontén, Eva, and van Bosse, Harold J. P.
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- 2015
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25. Gait dynamics in the wide spectrum of children with arthrogryposis: a descriptive study.
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Eriksson, Marie, Bartonek, Åsa, Pontén, Eva, and Gutierrez-Farewik, Elena M
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Background: Arthrogryposis Multiplex Congenita (AMC) is a heterogeneous condition characterized by multiple joint contractures at birth. Greater movements in the trunk and pelvis during walking have been observed in children with AMC using orthoses compared to those wearing only shoes. This study investigated gait dynamics in children with AMC and identified compensatory mechanisms that accommodate walking.Methods: Twenty-six children with AMC who walked with orthoses or shoes and a control group consisting of 37 typically-developing children were evaluated in 3D gait analysis. Children with AMC were divided into subgroups based on which joints needed to be stabilized in the sagittal plane; AMC1 used knee-ankle-foot orthoses (KAFOs) with locked knee joints, AMC2 used KAFOs with open knee joints or ankle-foot orthoses, and AMC3 used shoes.Results: The Gait Deviation Index was lower in AMC groups than in the control group, with the lowest in AMC1. Excessive trunk movements in frontal and transverse planes were observed in AMC2 and especially in AMC1. Lower hip flexion moment was found in AMC1, while AMC2 and AMC3 showed similar hip flexion moments as the control group. Knee extension moments were similar between the groups. In the frontal plane there were only small differences between the groups in hip abduction moment. A joint work analysis indicated greater contribution from the hip muscles to overall positive work in AMC groups, particularly in AMC1, than in the control group.Conclusion: All AMC groups showed less hip extension than the control group, but hip flexion moment was significantly lower only in AMC1, which can be attributed to their gait strategy with bilateral locked KAFOs. AMC1, who had weak knee extensors, were helped by their locked KAFOs and therefore showed similar knee extension moment as the other groups. This finding, together with their gait patterns, demonstrates the children's high reliance on hip muscles and presumably trunk muscles to provide propulsion. Our study shows that with adequate orthotic support, children with AMC and even with severe weakness and contractures can achieve walking. [ABSTRACT FROM AUTHOR]- Published
- 2015
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26. Handbook of Pediatric Orthopedics.
- Author
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Pontén, Eva
- Subjects
PEDIATRIC orthopedics ,NONFICTION - Abstract
The article reviews the book "Handbook of Pediatric Orthopedics," 2nd revised edn., edited by Paul D. Sponseller.
- Published
- 2011
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