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Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy.
- Source :
- Developmental Medicine & Child Neurology; Oct2021, Vol. 63 Issue 10, p1204-1212, 9p
- Publication Year :
- 2021
-
Abstract
- Skeletal muscle in individuals with CP also contains lower amounts of mtDNA, potentially indicating fewer mitochondria in CP skeletal muscle compared with typically developing muscle. We compared skeletal muscle samples from children with cerebral palsy (CP) and typically developing children and observed evidence of reduced mtDNA and OXPHOS protein content in CP skeletal muscle, indicating reduced mitochondrial abundance. Cerebral palsy (CP) muscle contains fewer energy-generating organelles than typically developing muscle. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00121622
- Volume :
- 63
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Developmental Medicine & Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 152310858
- Full Text :
- https://doi.org/10.1111/dmcn.14964