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There are around 24 distinct lipid vesicles described in the literature that are similar to vesicular systems such as liposomes. Liposome-like structures are formed by combining certain amphiphilic lipids with a suitable stabiliser. Since their discovery and classification, self-assembled liposome-like structures as active drug delivery vehicles captured researchers' curiosity. This comprehensive study included an in-depth literature search using electronic databases such as PubMed, ScienceDirect and Google Scholar, focusing on studies on liposome and liposomes like structure, discussed in literature till 2024, their sizes, benefits, drawback, method of preparation, characterisation and pharmaceutical applications. Pharmacosomes, cubosomes, ethosomes, transethosomes, and genosomes, all liposome-like structures, have the most potential due to their smaller size with high loading capacity, ease of absorption, and ability to treat inflammatory illnesses. Genosomes are futuristic because of its affinity for DNA/gene transport, which is an area of focus in today's treatments. This review will critically analyse the composition, preparation procedures, drug encapsulating technologies, drug loading, release mechanism, and related applications of all liposome-like structures, highlighting their potential benefits with enhanced efficacy over each other and over traditional carriers by paving the way for exploring novel drug delivery systems in the Pharma industry. [ABSTRACT FROM AUTHOR]

Satellite DNA repeats are repetitive DNA sequences found in eukaryotic genomes, typically consisting of short DNA motifs repeated in tandem arrays. Despite the vast body of literature on satellite DNA repeats in other taxa, investigations specifically targeting Tettigoniidae remain conspicuously absent. Our study aims to fill a critical gap in our understanding of satellitome evolutionary processes shaping Tettigoniidae genomes. Repeatome analysis revealed that the Meconema thalassinum genome comprises 92%, and Phryganogryllacris superangulata had the lowest value of 34%, with an average of 67% in other Tettigoniidae species. The analysis reveals significant variation in the number of satellite DNA repeats across species of the Tettigoniidae family, with M. thalassinum exhibiting the highest count, 246, reported in insects to date and the lowest count, 10, in Pholidoptera griseoptera. Ruspolia dubia and Ruspolia yunnana, which are congeneric species, showcase distinct counts of 104 and 84 families, respectively. Satellite DNA repeats in R. dubia exhibit the highest abundance, constituting 17.2% of the total genome, while the lowest abundance was reported in P. griseoptera, at 5.65%. The genome size correlates weakly with the satellite DNA family count (rs = 0.42, p = 0.29), but a strong correlation exists between satellite abundance and family number (rs = 0.73, p = 0.03). Moreover, the analysis of satellite DNA gain and loss patterns provides insights into the amplification and homogenization of satellite DNA families within the genome, with species-specific repeats exhibiting a positive trend toward amplification. The chromosomal distribution in M. thalassinum displayed that the highest accumulation was observed on Chr12, Chr01, and Chr04, constituting 17.79%, 17.4%, and 17.22% of the total chromosome size, respectively. The chromosome-specific propagation of satellite DNA families was evident, with MthSat01 solely on chromosome 1 and MthSat170 on chromosome 2, sharing 1.64% and 2.33%. The observed conservation and variations in satellite DNA number and abundances, along with distinct patterns of gain and loss, indicate the influence of potentially diverse evolutionary processes shaping the genomic landscape of these insects, which requires further investigation. Furthermore, the differential accumulation of satellite DNA on specific chromosomes implies that potential chromosome-specific functions or structural features influence the retention and proliferation of satellite sequences. [ABSTRACT FROM AUTHOR]

Transposable elements (TEs) are DNA sequences that can move or replicate within a genome, and their study has become increasingly important in understanding genome evolution and function. The Tridactylidae family, including Xya riparia (pygmy mole cricket), harbors a variety of transposable elements (TEs) that have been insufficiently investigated. Further research is required to fully understand their diversity and evolutionary characteristics. Hence, we conducted a comprehensive repeatome analysis of X. riparia species using the chromosome-level assembled genome. The study aimed to comprehensively analyze the abundance, distribution, and age of transposable elements (TEs) in the genome. The results indicated that the genome was 1.67 Gb, with 731.63 Mb of repetitive sequences, comprising 27% of Class II (443.25 Mb), 16% of Class I (268.45 Mb), and 1% of unknown TEs (19.92 Mb). The study found that DNA transposons dominate the genome, accounting for approximately 60% of the total repeat size, with retrotransposons and unknown elements accounting for 37% and 3% of the genome, respectively. The members of the Gypsy superfamily were the most abundant amongst retrotransposons, accounting for 63% of them. The transposable superfamilies (LTR/Gypsy, DNA/nMITE, DNA/hAT, and DNA/Helitron) collectively constituted almost 70% of the total repeat size of all six chromosomes. The study further unveiled a significant linear correlation (Pearson correlation: r = 0.99, p-value = 0.00003) between the size of the chromosomes and the repetitive sequences. The average age of DNA transposon and retrotransposon insertions ranges from 25 My (million years) to 5 My. The satellitome analysis discovered 13 satellite DNA families that comprise about 0.15% of the entire genome. In addition, the transcriptional analysis of TEs found that DNA transposons were more transcriptionally active than retrotransposons. Overall, the study suggests that the genome of X. riparia is complex, characterized by a substantial portion of repetitive elements. These findings not only enhance our understanding of TE evolution within the Tridactylidae family but also provide a foundation for future investigations into the genomic intricacies of related species. [ABSTRACT FROM AUTHOR]

The development of radar absorbing materials is a well-researched area with applications in electronics and stealth technology. In this work, two-phase and three-phase systems were produced in which a nano-conducting and magnetic charge were embedded in an insulating polymer matrix. Nickel spinel ferrite was synthesizes using a wet chemical route with a magnetic character, while the graphene nano-filler is a conductive part, both were built into an insulating polymer matrix. Various concentrations were produced for the two-phase system (PVDF polyvinylidene fluoride/graphene) and a selected nano-filler concentration, spinel ferrite, which was incorporated by upto 30% of the weight. These two-phase and three-phase hybrid systems were fabricated using the solution casting route and exemplified using Wide Angle X-ray Diffraction (WAXD), Scanning Electron Microscope (SEM), Impedance Analyzer, Final Tensile Tester (IAFTT) and Network Analyzer Vector (VNA). A summary is presented with recommendations for setting up instruments related to the laboratory. [ABSTRACT FROM AUTHOR]

The study aimed to investigate the association between incidental exposure on social media political contents and political participation. Social networking sites play an important role in political participation. While existing literature extensively explores the impact of social media on political engagement in Pakistan, there is a notable gap in understanding the influence of incidental exposure on social media on political participation. In this Research quantitative research design was used. A survey method was used to collect data from the chosen sample of 300 respondents. The data was collected online through purposive sampling. The findings of the study reveal that people mostly use YouTube, Facebook and Instagram. Furthermore, Incidental exposure on social media leads to political information acquiring and also leads people to participate in political activities. This study underscores their capacity to engage individuals previously disinterested in politics. These platforms emerge as catalysts for political involvement, particularly in the context of Pakistan [ABSTRACT FROM AUTHOR]

Affective computing is an important research area for developing an emotion recognition system. In such systems, stimuli for emotion elicitation are standard dynamic range (SDR) multimedia content. This study uses high dynamic range (HDR) multimedia content that effectively presents the scene's inherent colors and high dynamic range of luminance as stimuli for emotion elicitation, and its impact on human emotional experience with different personality traits is explored. For this purpose, four low and high-valence multimedia clips in SDR and HDR versions were shown to sixty subjects. Their emotional experience was recorded on a valence-arousal plane, which is then statistically analyzed in terms of the type of content and human personality traits. The results of the t-test with a 95% confidence interval show that HDR multimedia content elicits better emotions than SDR multimedia content and can be effectively utilized in emotion recognition systems for better emotion elicitation. [ABSTRACT FROM AUTHOR]

Transposable elements (TEs) are a major component of eukaryotic genomes and are present in almost all eukaryotic organisms. TEs are highly dynamic between and within species, which significantly affects the general applicability of the TE databases. Orthoptera is the only known group in the class Insecta with a significantly enlarged genome (0.93-21.48 Gb). When analyzing the large genome using the existing TE public database, the efficiency of TE annotation is not satisfactory. To address this limitation, it becomes imperative to continually update the available TE resource library and the need for an Orthoptera-specific library as more insect genomes are publicly available. Here, we used the complete genome data of 12 Orthoptera species to de novo annotate TEs, then manually re-annotate the unclassified TEs to construct a non-redundant Orthoptera-specific TE library: Orthoptera-TElib. Orthoptera-TElib contains 24,021 TE entries including the re-annotated results of 13,964 unknown TEs. The naming of TE entries in Orthoptera-TElib adopts the same naming as RepeatMasker and Dfam and is encoded as the three-level form of "level1/level2-level3". Orthoptera-TElib can be directly used as an input reference database and is compatible with mainstream repetitive sequence analysis software such as RepeatMasker and dnaPipeTE. When analyzing TEs of Orthoptera species, Orthoptera-TElib performs better TE annotation as compared to Dfam and Repbase regardless of using low-coverage sequencing or genome assembly data. The most improved TE annotation result is Angaracris rhodopa, which has increased from 7.89% of the genome to 53.28%. Finally, Orthoptera-TElib is stored in Sqlite3 for the convenience of data updates and user access. [ABSTRACT FROM AUTHOR]

Introduction: Growing antimicrobial resistance (AMR) and decreasing efficacy of the available antimicrobials have become a significant public health concern. The antimicrobial stewardship program (ASP) ensures the appropriate use of antimicrobials and mitigates resistance prevalence through various interventions. One of the core components of the ASP is to educate healthcare workers (HWs). Therefore, this study aims to identify the impact of a pharmacist-led educational intervention targeting knowledge, attitude, and practices regarding rational antibiotic use among healthcare professionals in a secondary care hospital in Punjab. Methods: This is a single-center, questionnaire-based, pre-post interventional study conducted over a six-month time period. Data analysis was conducted using SPSS version 26. Results: Regarding the pre-interventional knowledge, attitude, and practice (KAP) score of the respondents, 90.3% had a good knowledge score, 81.5% had a positive attitude, and 72.3% of HWs (excluding doctors) had a good practice score. Additionally, 74.6% of the doctors had a good practice score. After educational intervention, there was a significant improvement in the knowledge, attitude, and practice of the respondent HWs (p-value <0.001). Furthermore, males have higher knowledge scores compared to females in the pre- and post-intervention stages (p-value <0.05), and doctors differ from nurses regarding knowledge scores in both pre- and post-intervention stages. Conclusion: Considering educational programs as the backbone of the ASP, it is imperative to sustain efforts in the ongoing educational programs of HWs to foster high awareness and adherence to the ASP among HWs. [ABSTRACT FROM AUTHOR]

Ajuga bracteosa (family: Lamiaceae), commonly known as kauri booti, is an important ethnomedicinal plant. The current research was conducted to appraise and compare the in vitro antioxidant and antibacterial profiles as well as in vivo wound healing potentials of Ajugarin I and A. bracteosa extract. Ajugarin I and polyphenols in A. bracteosa were enumerated by reversed-phase high- performance liquid chromatography analysis that confirmed significant amounts of Ajugarin I (2.2 ± 0.02 Mg/mg DW) and other phenolic compounds (14 out of 17 standards). A. bracteosa (374.4 ± 0.20 Mg AAE/mg of DW, 201.9 ± 0.20 Mg AAE/mg of DW, 87 ± 0.30%) showed a higher antioxidant profile compared to Ajugarin I (221.8 ± 0.50 Mg AAE/mg of DW, 51.8 ± 0.40 Mg AAE/mg of DW, 27.65 ± 0.80%) with 1.86-, 3.89-, and 3.15-fold greater activity in ferric reducing antioxidant power, total antioxidant capacity, and free radical scavenging assays, respectively. Likewise, A. bracteosa showed antibacterial activity against 3/5 strains (MIC 25-200 Mg/ml) than Ajugarin I (2/5 strains; MIC 50-200 Mg/ml). Hemolytic (<2% hemolysis) and dermal toxicity tests rendered both samples non-toxic. Additionally, A. bracteosa (100 ± 2.34% at day 12; 9.33 ± 0.47 days) demonstrated 1.11- and 1.24-fold higher percent wound contraction and epithelization time, respectively, than Ajugarin I (95.6 ± 1.52% at day 12; 11.6 ± 0.47 days) as assessed by an excision wound model in mice. Histopathological examination further reinforced the better wound healing potential of A. bracteosa with good epithelization, collagen synthesis, fibroblast proliferation, and revascularization. Briefly, we endorse the significant comparative antioxidant, antibacterial, and wound healing activities of A. bracteosa and Ajugarin I and present these as prospective candidates for wound healing drugs. [ABSTRACT FROM AUTHOR]

We study potential non‐targeted effects of a large‐scale national conditional cash transfer program—Peru's Juntos—on the fertility and reproductive decisions of adult beneficiaries. We use an event study design, exploiting time and geographic variation in the rollout of the program, to identify the causal effects of the program. We find that Juntos decreases the number of children that adult beneficiaries have and that these effects persist over time. We explore various mechanisms and find that Juntos does not affect fertility preferences but rather empowers women to avoid unwanted births. We provide evidence that this decrease is most likely due to better access to and more extensive use of modern birth control methods. [ABSTRACT FROM AUTHOR]

Interactive wound dressings have displayed promising outcomes in enhancing the wound healing process. This study focuses on creating a nanocomposite wound dressing with interactive and bioactive properties, showcasing potent antioxidant effects. To achieve this, we developed cerium oxide nanoparticles utilizing curcumin as both the reducing and capping agent. Characterization techniques such as SEM, EDX, DLS, Zetasizer, FTIR, and XRD were utilized to analyze the cerium oxide nanoparticles synthesized through a green approach. The image analysis on the obtained TEM images showed that the curcumin-assisted biosynthesized CeO2NPs have a size of 18.8 ± 4.1 nm. The peaks located at 28.1, 32.7, 47.1, 56.0, 58.7, 69.0, and 76.4 correspond to (111), (200), (220), (311), (222), (400), and (331) crystallographic planes. We applied the Debye-Scherrer equation and observed that the approximate crystallite size of the biosynthesized NPs is around 8.2 nm based on the most intensive broad Bragg peak at 28.1°. The cerium oxide nanoparticles synthesized were integrated into an alginate hydrogel matrix, and the microstructure, porosity, and swelling behavior of the resulting wound dressing were assessed. The characterization analyses provided insights into the physical and chemical properties of the green-synthesized cerium oxide nanoparticles and the alginate hydrogel-based wound dressing. In vitro studies demonstrated that the wound dressing based on alginate hydrogel exhibited favorable antioxidant properties and displayed hemocompatibility and biocompatibility. Animal studies conducted on a rat full-thickness skin wound model showed that the alginate hydrogel-based wound dressing effectively accelerated the wound healing process. Overall, these findings suggest that the alginate hydrogel-based wound dressing holds promise as a highly effective material for wound healing applications. [ABSTRACT FROM AUTHOR]

A 46‐year‐old woman underwent pericardiocentesis and pericardial window for recurrent pericardial effusion. She presented 17 months later with signs and symptoms consistent with constrictive pericarditis. Cardiac magnetic resonance imaging revealed an infiltrative mass surrounding the pericardium. A transcutaneous core needle biopsy of the pericardium confirmed the diagnosis of pericardial mesothelioma. [ABSTRACT FROM AUTHOR]

(1) Background: A possible solution to antimicrobial resistance (AMR) is synergism with plants like Artemisia brevifolia Wall. ex DC. (2) Methods: Phytochemical quantification of extracts (n-hexane (NH), ethyl acetate (EA), methanol (M), and aqueous (Aq)) was performed using RP-HPLC and chromogenic assays. Extracts were screened against resistant clinical isolates via disc diffusion, broth dilution, the checkerboard method, time–kill, and protein quantification assays. (3) Results: M extract had the maximum phenolic (15.98 ± 0.1 μg GAE/mgE) and flavonoid contents (9.93 ± 0.5 μg QE/mgE). RP-HPLC displayed the maximum polyphenols in the M extract. Secondary metabolite determination showed M extract to have the highest glycosides, alkaloids, and tannins. Preliminary resistance profiling indicated that selected isolates were resistant to cefixime (MIC 20–40 µg/mL). Extracts showed moderate antibacterial activity (MIC 60–100 µg/mL). The checkerboard method revealed a total synergy between EA extract and cefixime with 10-fold reductions in cefixime dose against resistant P. aeruginosa and MRSA. Moreover, A. brevifolia extracts potentiated the antibacterial effect of cefixime after 6 and 9 h. The synergistic combination was non- to slightly hemolytic and could inhibit bacterial protein in addition to cefixime disrupting the cell wall, thus making it difficult for bacteria to survive. (4) Conclusion: A. brevifolia in combination with cefixime has the potential to inhibit AMR. [ABSTRACT FROM AUTHOR]

Due to population crisis and use of increasing number of artificial and un-natural components in our daily lives as well as in industry might result in toxic waste discharged leading to poor water quality. This in turn destroys lives and might end up in our rivers, therefore leading to monitoring water quality in the 21st century becoming more difficult. As per UN Sustainable Developments Goals (SDG) 6.3, the 2030 agenda includes a dedicated goal on water and sanitation that sets out to ensure availability for safe and clean drinking water for everyone and appropriate methods to improve water quality. It is shown in the paper to what measures and steps can be taken in order to avoid unhealthy water for drinking and domestic use. Further, an attempt has been made to present a summary of the ambient water quality of Gulistan e Johar, Karachi. Monitoring water quality aims to gather quantitative data on the physical, chemical and biological properties of water by statistical sampling. An evaluation and analyzation of Karachi Water and Sewerage Board (KWSB) water with World Health Organization (WHO) standards is shown to conclude if it is safe for drinking purposes and consumption. This paper possesses water treatment methods along with its research problem. It further aims to review and propose for implementation of water quality objectives to ensure safe and clean drinking water. In the last section, a recommendation has been given to KW&SB for what steps should be taken to make the water safe for drinking purpose. [ABSTRACT FROM AUTHOR]

This paper studies the effects of minimum wages in Indonesia around the time of birth on child height-for-age Z scores (HAZ) up to five years of age. Using variations in annual fluctuations in real minimum wages in different Indonesian provinces, it finds that children exposed to increases in minimum wages in their birth years have higher HAZ in the first five years of their lives. The estimated impacts are based on difference-in-differences models with biological-mother fixed effects and year-of-birth fixed effects and are robust to inclusion of multiple time-varying factors. The impacts are prominent particularly among male children. [ABSTRACT FROM AUTHOR]

A 16‐year‐old male with past medical history of congenital atrial septal defect surgical repair, presented with recurrent pericarditis secondary to post‐cardiotomy injury syndrome (PCIS), After failing medical therapy, he ultimately underwent pericardiectomy for symptom resolution, PCIS is underdiagnosed in children and should be considered in patients with recurrent chest, pain. [ABSTRACT FROM AUTHOR]

Income distribution models can be useful for describing the economic properties of a population. In this study, three-part composite Pareto models are fitted to the income distribution in Malaysia for the years 2007, 2009, 2012, 2014, and 2016. The three-part composite Pareto models divide the population into three parts, each following a different distribution model. The lower part follows the inverse Pareto distribution, the upper part follows the Pareto distribution, and the middle part follows another unspecified distribution model. For application in income data, the use of Gaussian mixture distribution is proposed for the middle part, making the inverse Pareto–Gaussian mixture-Pareto distribution model semi-parametric. From the model, it is found that the levels of income inequality in the lower and upper income groups decrease over the period of study. Additionally, the proportion of data following the inverse Pareto distribution in the model is highly correlated with the official absolute poverty incidence. [ABSTRACT FROM AUTHOR]

The 1,3,4-oxadiazole derivatives Ox-6a-f have been synthesized by incorporating flurbiprofen moiety with the aim to explore the potential of target molecules to decrease the oxidative stress. The title compounds Ox-6a-f were prepared by simple reactions in which a flurbiprofen –COOH group was esterified with methanol in an acid-catalyzed medium, which was then reacted with hydrazine to afford the corresponding hydrazide. The acid hydrazide was then cyclized into 1,3,4-oxadiazole-2-thiol by reacting with CS2 in the presence of KOH. The title compounds Ox-6a-f were synthesized by the reaction of an –SH group with various alkyl/aryl chlorides, which involves an S-alkylation reaction. The structures of the synthesized Ox-6a-f derivatives were ascertained by spectroscopic data. The in silico molecular docking was performed against target proteins cyclooxygenase-2 COX-2 (PDBID 5KIR) and cyclooxygenase-1 COX-1 (PDBID 6Y3C) to determine the binding affinity of the synthesized compounds with these structures. It has been inferred that most of the synthesized compounds bind well with an active binding site of 5KIR compared to 6Y3C, and especially compound Ox-6f showed excellent binding affinity (7.70 kcal/mol) among all synthesized compounds Ox-6a-f. The molecular dynamic (MD) simulation has also been performed to check the stability of docking complexes of ligands with COX-2 by determining their root mean square deviation and root mean square fluctuation. Little fluctuation was observed in case of Ox-6f, which forms the most stable complex with COX-2. The comprehensive antioxidant potential of the synthesized compounds has been evaluated by determining their free radical scavenging activity, including DPPH, OH, nitric oxide (NO), and iron chelation assay. The derivative Ox-6f showed promising results with 80.23% radical scavenging potential at a dose of 100 µg/mL while ascorbic acid exhibited 87.72% inhibition at the same dose. The anti-inflammatory activity of the final products has also been performed, and inflammatory markers were assayed, such as a thiobarbituric acid-reducing substance, nitric oxide, interleukin-6 (IL-6), and COX-2. The derivatives Ox-6d and Ox-6f displayed higher anti-inflammatory activity, exhibiting 70.56% and 74.16% activity, respectively. The results were compared with standard ibuprofen, which showed 84.31% activity at the same dose, 200 µg/mL. The anti-inflammatory potential has been performed by following the carrageen-induced hind paw edema model, and results showed that derivative Ox-6f exhibited 79.83% reduction in edema volume compared to standard ibuprofen, which reduced 84.31% edema volume. As dry lab and wet lab results confirm each other, it has been deduced that derivative Ox-6f may serve as the lead structure to design potent compounds to address oxidative stress. [ABSTRACT FROM AUTHOR]

Background and Purpose: In recent years, studies and interest in human behaviour in relation to the halal industry have been growing. The process of understanding the reasons for planning behaviour intention is not an easy path. Intentions are provoked by an individual's attitude which effect on how individuals making per purchase decision (Blackwell, Miniard, & Engel, 2001; Viksne, Salkovska, Gaitniece, & Puke, 2016). Human beings are complex and this complexity helps in having contradictions in an individual's attitude. Theory Planned Behavior (TPB) was created based on the theory of social psychology, and congruity theory was used as a theoretical framework for creating the current conceptual model. The main objective of the study is to examine the relationship between Spiritual intelligence (SQ), Spiritual Congruence (SC) and Accounting Literacy (AL) towards attitude and intention to purchase Halal product among the Generation Alpha. Methodology: To provide insight from this generation, the current study conducted a survey within the students of Faculty Economics and Muamalat, USIM for five programs offered. The survey reached 181 respondents, those who had experience in consuming halal products. The research instrument which consists of 31 scale items were utilized using a Likert scale and were then administered via questionnaire administered approach of using SPSS. Findings: Based on the finding it indicates that only SQ and SC have positive and significant relationship towards attitude which is represented by 0.006 for SQ and 0.022 for SC. However, AL does not reflect significant relationship with attitude. Contributions: The implication of the finding indicates that the education structure which embedded the Islamic elements could influence the attitude of the students towards Halal products. The finding could be the interest of the authorities and bodies related to Halal industry to create awareness among Alpha generation. [ABSTRACT FROM AUTHOR]

With the evolution in technology, communication based on the voice has gained importance in applications such as online conferencing, online meetings, voice-over internet protocol (VoIP), etc. Limiting factors such as environmental noise, encoding and decoding of the speech signal, and limitations of technology may degrade the quality of the speech signal. Therefore, there is a requirement for continuous quality assessment of the speech signal. Speech quality assessment (SQA) enables the system to automatically tune network parameters to improve speech quality. Furthermore, there are many speech transmitters and receivers that are used for voice processing including mobile devices and high-performance computers that can benefit from SQA. SQA plays a significant role in the evaluation of speech-processing systems. Non-intrusive speech quality assessment (NI-SQA) is a challenging task due to the unavailability of pristine speech signals in real-world scenarios. The success of NI-SQA techniques highly relies on the features used to assess speech quality. Various NI-SQA methods are available that extract features from speech signals in different domains, but they do not take into account the natural structure of the speech signals for assessment of speech quality. This work proposes a method for NI-SQA based on the natural structure of the speech signals that are approximated using the natural spectrogram statistical (NSS) properties derived from the speech signal spectrogram. The pristine version of the speech signal follows a structured natural pattern that is disrupted when distortion is introduced in the speech signal. The deviation of NSS properties between the pristine and distorted speech signals is utilized to predict speech quality. The proposed methodology shows better performance in comparison to state-of-the-art NI-SQA methods on the Centre for Speech Technology Voice Cloning Toolkit corpus (VCTK-Corpus) with a Spearman's rank-ordered correlation constant (SRC) of 0.902, Pearson correlation constant (PCC) of 0.960, and root mean squared error (RMSE) of 0.206. Conversely, on the NOIZEUS-960 database, the proposed methodology shows an SRC of 0.958, PCC of 0.960, and RMSE of 0.114. [ABSTRACT FROM AUTHOR]

The ALICE collaboration at LHC has recently measured the inclusive charged-particle jets production with different resolution parameters of 0.2, 0.3, 0.4, 0.5, 0.6 and 0.7 in pp collisions at s = 13 TeV in the transverse momentum range of 5 < p T , j e t ch < 140 GeV/c and pseudorapidity range of | η jet | < 0.9 - R . In this work, we have fitted the inclusive charged-particles jet production measured by the ALICE Collaboration by the Tsallis function with thermodynamical consistence to measure the freeze-out parameters: effective temperature ( T eff ), chemical potential (μ ) and non-extensive parameter (q). The quality of the Tsallis fits with fixed μ = 0 chemical potential has proved to be significantly better than those with fitted μ value. The fit parameters, q and T eff measure the degree of deviation from the equilibrium state and the effective temperature of the thermalized system, respectively. We have established the dependence of the effective temperature, T eff , and non-extensive parameter, q, on the value of the jet resolution parameter, R. We found out that the effective temperature, T eff , of the Tsallis function shows a steady rise with increasing the jet resolution parameter. Also, a decrease in the non-extensive parameter q has been observed when the jet resolution parameter increases. [ABSTRACT FROM AUTHOR]

Purpose of Review: In this review, we discuss the prevalence of cardiovascular disease in people with type 1 diabetes. We outline key risk factors associated with increased cardiovascular event rates and discuss the prevalence and mechanisms underlying hyperlipidemia in people with type 1 diabetes. Finally, we summarize the evidence to support early and more aggressive lipid-lowering therapy in people with type 1 diabetes and review current guideline recommendations. Recent Findings: Comprehensive treatment of hyperglycemia, hypertension, and hyperlipidemia reduces adverse cardiovascular outcomes in people with type 2 diabetes. In contrast, evidence to support a comparable benefit of intensive cardiovascular risk factor management in people with type 1 diabetes is lacking from prospective, randomized trials and has only been shown in registries. Therefore, current treatment guidelines extrapolate prospective clinical trial evidence obtained in people with type 2 diabetes to provide similar treatment recommendations for people with type 1 and type 2 diabetes. Summary: Evidence supports the more aggressive treatment of cardiovascular risk factors in people with type 1 diabetes, who would likely benefit from early risk stratification and comprehensive risk factor management, including aggressive lipid-lowering therapy. [ABSTRACT FROM AUTHOR]

Constrictive pericarditis (CP) can result from uncontrolled inflammation of the pericardium. This can be due to various etiologies. CP can lead to both left- and right-sided heart failure with associated poor quality of life, so early recognition is key. The evolving role of multimodality cardiac imaging allows for earlier diagnosis and facilitates management to help mitigate this adverse outcome. This review discusses the pathophysiology of constrictive pericarditis, chronic inflammation and autoimmune etiologies, clinical presentation of CP, and advances in multimodality cardiac imaging for diagnosis and management. Echocardiography and cardiac magnetic resonance (CMR) imaging remain cornerstone modalities to evaluate this condition, whereas additional imaging modalities such as computed tomography and FDG-positron emission tomography can provide complementary information. Advances in multimodality imaging allow for a more precision diagnosis of constrictive pericarditis. There has been a paradigm shift in pericardial disease management with advances in multimodality imaging, especially CMR, to detect subacute and chronic inflammation. This has enabled imaging-guided therapy (IGT) to both help prevent and potentially reverse established constrictive pericarditis. [ABSTRACT FROM AUTHOR]

Arabic has three main vowels, which are the vowel /a/ (fathah), the vowel /i/ (kasrah), and the vowel /u/ (dˁammah). This study analyses the vowels of the Arabic Present Tense in jafʕal form which is related to the arrangement of letters. This study aims at helping Arabic language students who have difficulty determining the correct vowel of the three vowel fractions. In addition, this study can help linguists in general and Arabic linguists in particular to determine the vowel reading of the letter ʕayn (ع (on the active verb pattern of modern Arabic jafʕal which is divided into vowels /a/ (fathah), vowel /i/ (kasrah), and the vowel /u/ (dˁammah). This study applies a qualitative method. Al-Khali:l dictionary and al-MaɁaniy online dictionary were referred for data collection. Three syllable active verbs were analyzed as vowels for these three syllable active verbs in Arabic will change to three different vowels in the Present Tense of the verb. Based on the phonological method proposed by El-Wadi (2005), the analysis focused on the arrangement of the letters ʕayn (ع (in the Past Tense verb which is processed from the phonological method pioneered by Chomsky and Halle (1968). Clearly, the findings of the study have shown that there are effects on the vowel on the ʕayn (ع (active verb of the Arabic Present Tense caused by the arrangement of ʕayn (ع (on the active Arabic verb of the past. At the same time, this study provides an alternative that shows that the vowels at the position of the letter ʕayn (ع (of the active Arabic verb of the present time are non-random. [ABSTRACT FROM AUTHOR]

Aim: To investigate the prevalence, attitude, and pattern of self-medication practice for dental problems among adults in Kuantan, the state capital of Pahang, Malaysia. Materials and Methods: This cross-sectional study was conducted among adults over 18 years of age who live in Kuantan via self-administered online- and paper-based bilingual questionnaires. Descriptive statistics and chi-square analysis were run using IBM SPSS® Version 26 software. Results: From 275 respondents, one-fifth of respondents (21.8%) practised self-medication for dental problems and most of them obtained a mean attitude score of 21.7 ±2.5% out of 25. Most self-medicating respondents were from the age group of 18-27 years (78.3%), females (55%), singles (78.3%), resides urban area (75.0%), and students (71.7%), with a household income of

Vegetables are considered high value crops based on their growing areas and productivity, even if they are affected by a variety of insect pests throughout the whole growing season. Leaf miner is an immature of an insect that lives inside and consumes the leaf tissues of vegetable plants. Adult females of leaf miner puncture the leaf with their ovipositor, forming tube pattern, and feed on the punctured parts. Host plants survey of leaf miner in Multan (Pakistan) area was conducted. Twenty host plants were found in 2017, whereas twenty-four host plants were found infested with Liriomyza spp. (Diptera) in 2022 i.e., watermelon (24% infestation), long melon (75%), pumpkin (71%), round gourd (67%), snake melon (70%), bitter gourd (50%), long gourd (89%), bottle gourd (93%), pointed gourd (80%), snap gourd (86%), ridge gourd (83%), cucumber (98%), mung bean (98%), eggplant (60%), Petunia alba (88%), Zinnia elegies (30%), cotton (10%), okra (5%), berseem (7%), tomato (89%), Pea (52%) and Canola (28%). No infestation of leaf miners was observed on potato, chilies, and sweet potatoes. Color attraction results in 2017 and 2022 showed that there was maximum attraction of tomato leaf miner towards yellow sticky cards as compared to blue sticky cards. Varietal preference of tomato crop showed that Baby red variety was the most preferred by leaf miner (Liriomyza spp.), and comparatively Sehar was the least preferred variety. Field efficacy of four different insecticides against leaf miner were also tested. Insecticidal effects attributed as percent reduction of leaf miner infestation that showed the highest reduction values were observed after 7 DOA for Spinetoram (76.98%), whereas Bifenthrin (57%). Deltaphos (43 %) was the least toxic insecticide against Liriomyza spp. Integrated approaches are recommended to manage vegetable leaf miner like application of yellow sticky traps, discouraging preferred host plants, application of insecticides with novel modes of actions like spintoram and spinosad for effective management. [ABSTRACT FROM AUTHOR]

The pentacyclic triterpenoids (PTs) of plant origin are reputed to restrain prostate cancer (PCa) cell proliferation. This study aims to assess 3-epifriedelinol (EFD) isolated from aerial part of Ipomoea batatas against PCa and its potential mechanism, in vitro and in vivo. Molecular docking affirms good binding affinity of the compound with target proteins exhibiting binding energy of −7.9 Kcal/mol with BAX, −8.1 Kcal/mol (BCL-2), −1.9 Kcal/mol (NF-κB) and −8.5 Kcal/mol with P53. In the MTT assay, EFD treatment (3–50 µM) showed a significant (p < 0.05 and p < 0.01) dose and time dependent drop in the proliferative graph of DU145 and PC3, and an upsurge in apoptotic cell population. EFD displayed substantial IC50 against DU145 (32.32 ± 3.72 µM) and PC3 (35.22 ± 3.47 µM). According to Western blots, EFD administration significantly enhanced the cleavage of caspases and PARP, elevated BAX and P53 and decreased BCL-2 and NF-κB expression, thereby triggering apoptosis in PCa cells. When male Sprague Dawley rats were intoxicated with Bisphenol A (BPA), an apparent increase in prostate mass (0.478 ± 0.08 g) in comparison to control (0.385 ± 0.03 g) indicates prostatitis. Multidose treatment of EFD (10 mg/kg) significantly reduced prostate size (0.404 ± 0.05 g). EFD exhibited substantial curative potential in vivo, as hematological, hormonal and histopathological parameters have been significantly improved. Reduced peroxidation (TBARS), and suppression of inflammatory markers i.e., NO, IL-6 and TNF-α, signposts substantial antiinflammatory potential of the compound. Overall, EFD has shown better binding affinity with target molecules, acceptable ADMET profile, potent antiproliferative and apoptotic nature and significant reduction in inflamed prostate mass of rats. The present study demonstrates acceptable physicochemical and pharmacokinetic properties of the compound with excellent drugable nature, hence EFD in the form of standardized formulation can be developed as primary or adjuvant therapy against PCa and toxins-induced gonadotoxicity. [ABSTRACT FROM AUTHOR]

This study aimed to investigate factors that influence consumer purchase decision in Malaysian single-priced stores, which are also popularly known as RM2 stores. The study considered six factors that could affect purchase decision in RM2 stores, namely, corporate social responsibility (CSR), sales promotion, social media marketing, perceived value, store environment, and service quality. A quantitative research methodology was employed through a survey using questionnaires administered to 550 customers of the RM2 stores. The data gathered was then analysed through SPSS method to calculate the validity and reliability of the measurement items and to verify the impact of six independent variables on purchase decision. Based on the results, CSR, sales promotion, perceived value, and service quality had significant positive effects on purchase decision, while social media marketing and store environment proved to be insignificant. Among all the factors, perceived value had the strongest influence on purchase decision. The findings are important in assisting RM2 store retailers to understand the factors that affect consumer purchase decision which could help in improving sales. This study complements the current literature and addresses existing research gaps with regard to the linkages between factors that influence consumer purchase decision in Malaysian single-priced stores. [ABSTRACT FROM AUTHOR]

In this paper, we present a trait anxiety detection framework using resting-state electroencephalography (EEG) data. Our proposed framework consists of EEG data acquisition, pre-processing, feature extraction and selection, and classification stages. EEG data of 65 participants is recorded in an eye-open state for the duration of two minutes. The trait anxiety scores are gathered using the state-trait anxiety inventory questionnaire, which is used to label the participant's EEG data into two (non-anxious and anxious) and three (non-anxious, low anxious, and highly anxious) classes. Pre-processing of the recorded EEG data is performed using the onboard noise cancellation scheme of the MUSE EEG headband. Channel selection is performed by applying a t-test and analysis of variance on the power spectral densities for two and three classes of anxiety respectively. Five time-domain features are extracted from the selected EEG channels. The wrapper method for feature selection is applied for selecting an optimum subset of features, which are used to classify the trait anxiety. The highest classification accuracy of 87.69 % and 83.07 % using random forest classifier is achieved for two and three class anxiety classification respectively. Our proposed trait anxiety detection scheme outperforms existing schemes in terms of higher classification accuracy and reduced feature vector length. [ABSTRACT FROM AUTHOR]

Purpose of Review: To review myocarditis and pericarditis developing after COVID-19 vaccinations and identify the management strategies. Recent Findings: COVID-19 mRNA vaccines are safe and effective. Systemic side effects of the vaccines are usually mild and transient. The incidence of acute myocarditis/pericarditis following COVID-19 vaccination is extremely low and ranges 2–20 per 100,000. The absolute number of myocarditis events is 1–10 per million after COVID-19 vaccination as compared to 40 per million after a COVID-19 infection. Higher rates are reported for pericarditis and myocarditis in COVID-19 infection as compared to COVID-19 vaccines. Summary: COVID-19 vaccine–related inflammatory heart conditions are transient and self-limiting in most cases. Patients present with chest pain, shortness of breath, and fever. Most patients have elevated cardiac enzymes and diffuse ST-segment elevation on electrocardiogram. Presence of myocardial edema on T2 mapping and evidence of late gadolinium enhancement on cardiac magnetic resonance imaging are also helpful additional findings. Patients were treated with non-steroidal anti-inflammatory drugs and colchicine with corticosteroids reserved for refractory cases. At least 3–6 months of exercise abstinence is recommended in athletes diagnosed with vaccine-related myocarditis. COVID-19 vaccination is recommended in all age groups for the overall benefits of preventing hospitalizations and severe COVID-19 infection sequela. [ABSTRACT FROM AUTHOR]

Introduction: This study aims at the biological profiling of Allium sativum, Zingiber officinale, Nigella sativa, Curcuma longa, Mentha piperita, Withania somnifera, Azadirachta indica, and Lawsonia inermis as alternatives against onychomycosis to combat the treatment challenges. Methods: An extract library of aqueous (DW), ethyl acetate (EA), and methanol (M) extracts was subjected to phytochemical and antioxidant colorimetric assays to gauge the ameliorating role of extracts against oxidative stress. RP-HPLC quantified therapeutically significant polyphenols. Antifungal potential (disc diffusion and broth dilution) against filamentous (dermatophytes and non-dermatophytes) and non-filamentous fungi (yeasts; Candida albicans), synergistic interactions (checkerboard method) with terbinafine and amphotericin-B against resistant clinical isolates of dermatophytes (Trichophyton rubrum and Trichophyton tonsurans) and non-dermatophytes (Aspergillus spp., Fusarium dimerum, and Rhizopus arrhizus), time-kill kinetics, and protein estimation (Bradford method) were performed to evaluate the potential of extracts against onychomycosis. Results: The highest total phenolic and flavonoid content along with noteworthy antioxidant capacity, reducing power, and a substantial radical scavenging activity was recorded for the extracts of Z. officinale. Significant polyphenolics quantified by RP-HPLC included rutin (35.71 ± 0.23 μg/mgE), gallic acid (50.17 ± 0.22 μg/mgE), catechin (93.04 ± 0.43 μg/mgE), syringic acid (55.63 ± 0.35 μg/mgE), emodin (246.32 ± 0.44 μg/mgE), luteolin (78.43 ± 0.18 μg/mgE), myricetin (29.44 ± 0.13 μg/mgE), and quercetin (97.45 ± 0.22 μg/mgE). Extracts presented prominent antifungal activity against dermatophytes and non-dermatophytes (MIC-31.25 μg/ml). The checkerboard method showed synergism with 4- and 8-fold reductions in the MICs of A. sativum, Z. officinale, M. piperita, L. inermis, and C. longa extracts and doses of amphotericin-B (Amp-B) and terbinafine (against non-dermatophytes and dermatophytes, respectively). Furthermore, the synergistic therapy showed a time-dependent decrease in fungal growth even after 9 and 12 h of treatment. The inhibition of fungal proteins was also observed to be higher with the treatment of synergistic combinations than with the extracts alone, along with the cell membrane damage caused by terbinafine and amp-B, thus making the resistant fungi incapable of subsisting. Conclusion: The extracts of A. sativum, Z. officinale, M. piperita, L. inermis, and C. longa have proven to be promising alternatives to combat oxidative stress, resistance, and other treatment challenges of onychomycosis. [ABSTRACT FROM AUTHOR]

Triggering through abiotic stress, including chemical triggers like heavy metals, is a new technique for drug discovery. In this research, the effect of heavy metal Nickel on actinobacteria Streptomyces sp. SH-1327 to obtain a stress-derived compound was firstly investigated. A new compound cyclo-(D)-Pro-(D)-Phe (CDPDP) was triggered from the actinobacteria strain SH-1327 with the addition of nickel ions 1 mM. The stress compound was further evaluated for its antioxidant, analgesic, and anti-inflammatory activity against rheumatoid arthritis through in-vitro and in-vivo assays in albino mice. A remarkable in-vitro antioxidant potential of CDPDP was recorded with the IC50 value of 30.06 ± 5.11 μg/ml in DPPH, IC50 of 18.98 ± 2.91 against NO free radicals, the IC50 value of 27.15 ± 3.12 against scavenging ability and IC50 value of 28.40 ± 3.14 μg/ml for iron chelation capacity. Downregulation of pro-inflammatory mediators (NO and MDA), suppressed levels of pro-inflammatory cytokines (TNF-α, IL-6, IL-Iβ) and upregulation of expressions of anti-oxidant enzymes (GSH, catalase, and GST) unveiled its anti-inflammatory potential. CDPDP was analyzed in human chondrocyte cell line CHON-001 and the results demonstrated that CDPDP significantly increased cell survival, and inhibited apoptosis of IL-1β treated chondrocytes and IL-1β induced matrix degrading markers. In addition, to evaluate the mitochondrial fitness of CHON-001 cells, CDPDP significantly upregulated pgc1-α, the master regulator of mitochondrial biogenesis, indicating that CDPDP provides protective effects in CHON-001 cells. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile of the CDPDP showed that CDPDP is safe in cases of hepatotoxicity, cardiotoxicity, and cytochrome inhibition. Furthermore, docking results showed good binding of CDPDP with IL-6-17.4 kcal/mol, and the simulation studies proved the stability between ligand and protein. Therefore, the findings of the current study prospect CDPDP as a potent anti-oxidant and a plausible anti-arthritic agent with a strong pharmacokinetic and pharmacological profile. [ABSTRACT FROM AUTHOR]

Background: Transposable elements (TEs) have been likened to parasites in the genome that reproduce and move ceaselessly in the host, continuously enlarging the host genome. However, the Piwi-interacting RNA (piRNA) pathway defends animal genomes against the harmful consequences of TE invasion by imposing small-RNA-mediated silencing. Here we compare the TE activity of two grasshopper species with different genome sizes in Acrididae (Locusta migratoria manilensis♀1C = 6.60 pg, Angaracris rhodopa♀1C = 16.36 pg) to ascertain the influence of piRNAs. Results: We discovered that repetitive sequences accounted for 74.56% of the genome in A. rhodopa, more than 56.83% in L. migratoria, and the large-genome grasshopper contained a higher TEs proportions. The comparative analysis revealed that 41 TEs (copy number > 500) were shared in both species. The two species exhibited distinct “landscapes” of TE divergence. The TEs outbreaks in the small-genome grasshopper occurred at more ancient times, while the large-genome grasshopper maintains active transposition events in the recent past. Evolutionary history studies on TEs suggest that TEs may be subject to different dynamics and resistances in these two species. We found that TE transcript abundance was higher in the large-genome grasshopper and the TE-derived piRNAs abundance was lower than in the small-genome grasshopper. In addition, we found that the piRNA methylase HENMT, which is underexpressed in the large-genome grasshopper, impedes the piRNA silencing to a lower level. Conclusions: Our study revealed that the abundance of piRNAs is lower in the gigantic genome grasshopper than in the small genome grasshopper. In addition, the key gene HENMT in the piRNA biogenesis pathway (Ping-Pong cycle) in the gigantic genome grasshopper is underexpressed. We hypothesize that low-level piRNA silencing unbalances the original positive correlation between TEs and piRNAs, and triggers TEs to proliferate out of control, which may be one of the reasons for the gigantism of grasshopper genomes. [ABSTRACT FROM AUTHOR]

A tobacco chloroplast hypothetical open reading frame 4 (YCF4) has been reported as a non-essential assembly factor for photosynthesis based on an incomplete knockout of YCF4, just 93 of 184 amino acids from the N-terminus were knocked out. On the other hand, we removed the complete sequence of YCF4 from tobacco chloroplasts and observed that DYCF4 plants were unable to survive photoautotrophically as their growth was hampered in the absence of an external carbon supply, clearly showing that the YCF4 is essential for photosynthesis. Initially, the aadA gene was introduced into the tobacco plastome replacing the complete YCF4 gene through homologous recombination events. The replacement of YCF4 with aadA was confirmed by PCR and Southern blot analysis in DYCF4 plants. Homoplasmic DYCF4 plants had a light green phenotype, and the leaves became pale yellow as the plants grew older. The structure of chloroplasts of DYCF4 mutants of light green phenotype was studied using a transmission electron microscope (TEM), and the micrographs demonstrated structural anomalies in the chloroplasts; including shape, size, and grana stacking compared to the wild-type plants. Further, transcriptome analysis revealed that the expression of PSI, PSII, and ribosomal genes remained unchanged in ΔYCF4 plants. On the other hand, transcriptome levels of rbcL (Ribulose 1,5-bisphosphate carboxylase/oxygenase large subunit), LHC (Light-Harvesting Complex), and ATP Synthase (atpB and atpL) decreased, indicating that the YCF4 has the function(s) in addition to assembling the photosynthetic complex. This was confirmed by in-silico protein-protein interactions of full-length YCF4 as well as 93 and 91 of 184 amino acids from N- and C-termini of the full-length protein, which revealed that the C-terminus (91 aa) of YCF4 is important in interacting with other chloroplast proteins. These findings provide genetic support for the plastid YCF4 gene's critical role in regulating the plastid gene expression and assembling the photosynthetic complex. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to examine how much celebrity endorsement stimulates skin color racism in the cosmetics industry. Design/Methodology/Approach: The data were collected from Google Scholar and Web of Science published articles, and researchers had chosen 45 research articles. Some of the research articles used a quantitative research approach while others had used qualitative research approach. And for the current study, content analysis has been used. Findings: The study finds that celebrity endorsement does influence and promote racism, implying that when celebrities promote fairness products, people perceive themselves inferior due to darker skin tone that gives birth to the notion of racism. Brand Image intervenes in the relationship between Celebrity Endorsement and Racism, and also, intervenes in the relationship between Celebrity Endorsement and Purchase Intention. Limitations: This study is only limited to Google Scholar and Web of Science directory. Only forty‐five articles were taken from 2001 to 2021 year. Real examples were taken from all over the world, but especially from the Less Developed countries like Pakistan and India due to the huge population, rising income, and surging cosmetics industry. Hence, the findings of this study cannot be generalized to the Technologically Advanced Countries. Implications: It is obvious that firms design advertisement campaigns that can get consumers' attention. For this purpose, they engage celebrities to evoke more interest and awareness as well as perception. The study will help the management of different brands to understand that how they can improve their advertisements in a way that does not promote racism. And the celebrities, signing contracts with brands that promote racism, will keep in mind the negative influence these endorsements have on society while companies will make sure that they are also not promoting racism by making such promotional campaigns. [ABSTRACT FROM AUTHOR]

Initially described in 1936, non-bacterial thrombotic endocarditis (NBTE) is a rare entity involving sterile vegetations on cardiac valves. These vegetations are usually small and friable, typically associated with hypercoagulable states of malignancy and inflammatory diseases such as systemic lupus erythematosus. Diagnosis remains challenging and is commonly made post-mortem although standard clinical methods such as echocardiography (transthoracic and transesophageal) and magnetic resonance imaging may yield the clinical diagnosis. Prognosis of NBTE is poor with very high morbidity and mortality usually related to the serious underlying conditions and high rates of systemic embolization. Therapeutic anticoagulation with unfractionated heparin has been described as useful for short term prevention of recurrent embolic events in patients with NBTE but there are no guidelines for management of this disease. [ABSTRACT FROM AUTHOR]

Safe preclinical dose determination is predictive of human toxicity and can have a profound impact on the overall progress of the compound in early drug discovery process. In this respect, current study sought to investigate for the first time the acute and subacute oral toxicity of two pharmacologically active natural compounds i.e., withametelin and daturaolone in Sprague Dawley rats following OECD guideline 420 and 407, respectively. As per acute toxicity studies, withametelin and daturaolone were characterized as Globally Harmonized System (GHS) category 4 and 5 compounds, respectively. Sub-acute daily dose of withametelin was 5, 2.5, and 1.25 mg/kg but, for daturaolone, it was 10, 5, and 2.5 mg/kg. High dose (5 and 2.5 mg/kg) withametelin groups showed dose dependent changes in the general, hematological, biochemical and histopathological parameters in both sexes, the most prominent being hyperthyroidism while no toxicity was observed at lower doses (1.25 and 0.75 mg/kg), No Observable Adverse Effect Level (NOAEL) being 1.25 mg/kg. Daturaolone was comparatively safer and showed dose dependent significant changes in hepatic enzyme (Alanine Transaminase), bilirubin, creatinine, and glucose levels while histological changes in testes were also observed. Lower doses (5, 2.5, and 1.25 mg/kg) of daturaolone showed no significant toxic effects and 5 mg/kg was declared as its NOAEL. Depending upon our findings, starting effective oral dose levels of 1.25 mg/kg/day for withametelin and 5 mg/kg/day for daturaolone are proposed for repeated dose (up to 28 days) preclinical pharmacological evaluation models. Long term studies with more behavioral, biochemical, histopathological and hormonal parameters are proposed to strengthen the findings. [ABSTRACT FROM AUTHOR]

Anagallis arvensis (A. arvensis) belonging to the family Primulaceae is traditionally used for liver and kidney diseases. The aim of the study was to evaluate the uroprotective and hepatoprotective potentials of A. arvensis in cyclophosphamide-induced interstitial cystitis and paracetamol-induced hepatotoxicity rat model, respectively. Nociception, bladder weight, vesical vascular permeability, Gray's criteria for edema and hemorrhage, and levels of nitric oxide, catalase, and glutathione were estimated and studied in the cystitis model. Liver function test, lipid profile, and histopathological evaluation were carried out in the hepatoprotective activity. Oral administration of methanol extract of A. arvensis significantly reduced bladder weight, vesical vascular permeability, edema, hemorrhage, nitric oxide, IL-6, and TNF-α, while the level of catalase and glutathione peroxide was increased. In hepatoprotective activity, pretreatment with A. arvensis significantly decreased the level of liver markers (Bilirubin, ALT, AST, and ALP) and lipid profile (cholesterol, TG, LDL, and VLDL). Histopathological studies confirmed the biochemical findings of both studies. GC-MS analysis presented the presence of antioxidant phytoconstituents. Thus, it was concluded that A. arvensis might act as uroprotective and hepatoprotective due to the presence of antioxidant phytochemicals in the rodent model. Isolation and identification of phytochemicals present in the methanol extract of A. arvensis and evaluation of their exact mechanism of action become mandatory in future studies. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis and osteoarthritis overlap many molecular mechanisms of cartilage destruction. Wear and tear in cartilage is chondrocyte-mediated, where chondrocytes act both as effector and target cells. In current study, role ofβ2-AR was studied in chondrocytes both in vitro and in vivo. High grade inflammation in vitro and in vivo diseasemodels led to decline in anti-inflammatoryβ2-AR signaling and use of ß2-AR agonist attenuated arthritis symptoms. Detailed analysis in chondrocytes revealed that Isoprenaline (ISO) and Salbutamol (SBT) increased cell viability and relative Bcl-2 expression, meanwhile, decreased proteins levels of TNF-a, IL-6andIL-8 in arthritic chondrocytes when compared with control, respectively. SBT preserved physiological concentration of antioxidant enzymes (CAT, POD, SOD and GSH) in cartilage homogenates and ISO inhibited IL-1ß-mediated genotoxicity in arthritic chondrocytes. Moreover, β2-AR agonist increased mitochondrial biogenesis and proteoglycan biosynthesis by upregulating the gene expression of PGC1-a, NRF2 and COL2A1, Acan, respectively. ISO and SBT inhibited extracellular matrix (ECM) degradation by downregulating the gene expression of MMP1, MMP3, MMP9 and ADAMTS5 in vitro and in vivo study. In mechanism, β2-AR agonists decreasedβ-arrestin and GRK2 pathway, and as a resultmice receiving SBT did not exhibit severe disease. Hence our data suggestβ2-AR agonist administered at disease onset can inhibit receptor internalization by downregulating the expression ofβ-arrestin and GRK2 in chondrocytes. [ABSTRACT FROM AUTHOR]

Wind energy is a type of renewable energy that has received much attention in the electricity market. This study focuses on forecasting wind speed at Malacca state's Station. This paper proposes using a Group Method of Data Handling (GMDH) model with a hyperbolic tangent transfer function in forecasting wind speed data in Malacca state. The performance of this model is compared with three other models: Artificial neural network (ANN) hyperbolic tangent, ANN log sigmoid and GMDH model. In addition, this study investigates the impact of using different transfer functions in data-driven models for forecasting wind speed. Usually, the application of the GMDH model only implements the second-order polynomial as a partial description. However, in this study, we implement the hyperbolic tangent transfer function in the GMDH model. The forecasting model's accuracy is evaluated using mean absolute percentage error (MAPE), root mean square error (RMSE) and mean absolute error (MAE). The results show that the GMDH model with hyperbolic tangent is highly accurate with more negligible computational power than other models. The GMDH-hyperbolic tangent model managed to improve the forecasting performance of the conventional GMDH model by 11.21% in mean absolute percentage error and outperforms other ANN models. [ABSTRACT FROM AUTHOR]

No-referenceimage quality assessment (NR-IQA) techniques try to assess the quality of images without anyinformation regarding the pristine version of the image. NR-IQA becomes more challenging for images affected by multiple distortions and images taken in real-world scenarios. Most convolutional neural network (CNN) based NR-IQA techniques do not use visual saliency (VS) and the ones that do require a reference image for computation of VS map. This paper proposes a completely blind end-to-end NR-IQA methodology based on VS and convolutional neural network (CNN). It utilizes VS models to identify the significant region of the image that can be used for quality assessment. The VS methodology used in the proposed approach does not require a reference image for the extraction of VS map. The regions proposed by the VS model are then utilized by a CNN to predict the quality score. The proposed methodology is tested on three publicly available multi-distorted image quality assessment databases i.e., live multiply distorted image quality (MDIQ) database, multiply distorted image database (MDID), and the live in the wild challenge (CLIVE) database. The proposed methodology is also tested over three VS models extract VS maps without the reference image. The experimental results show that using VS models improve the performance of CNN for predicting the image quality score. [ABSTRACT FROM AUTHOR]

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This study aims to evaluate the mediating role of sustainability in the relationship between environmental-accounting (EA) disclosures and audit quality (AQ) and firm performance (FP) by using GDP and firm size as the controlled variables. Data were collected from the annual and sustainability reports of 80 manufacturing firms that were listed on the PSX during the last 10 years (2011–2020). STATA 13 software and a multiple-regression model were used. The findings that were deduced from the empirical results indicate that EA with sustainability has a significant negative effect on both proxies of the FP (ROA and ROE). By contrast, AQ with sustainability has an insignificant negative impact on firm performance. This research contributes to the scarce literature and compares the level of EA with sustainability reporting and its impact on the FP with the controlled variables GDP and firm size. This study also contributes to the execution of the reporting and the assurance of sustainability, and it helps regulatory bodies with the integral development of reporting and the assurance of EA. [ABSTRACT FROM AUTHOR]

In this study, the Weibull distribution with various numerical estimation methods is utilized for the assessment of wind energy potential in Mersing and Port Dickson, Malaysia, by considering different monsoon seasons, i.e., northeast and southwest monsoons. This assessment is conducted based on hourly wind speed data obtained from the Malaysian Meteorological Department and the Department of Environment, Malaysia. A total of 28 numerical estimation methods are presented, and their performances are first investigated through a Monte Carlo simulation. The results of the Monte Carlo simulation indicate that no particular method outperforms all other methods. In different settings, i.e., different sample sizes and shape parameters, certain methods are more efficient than others in estimating the Weibull parameters. Based on the simulation results, 24 out of 28 numerical estimation methods are utilized for wind energy potential assessment in Mersing and Port Dickson. The performance efficiency of all the considered methods is evaluated using an integrated approach comprising four goodness of fit criteria, the modified Kolmogorov − Smirnov, modified Anderson − Darling, modified Cramér–von Mises, and power density error. Using this integrated approach allow us to obtain a single-value goodness of fit measure known as the global score to determine the best method. Based on the best fitted Weibull model, the wind characteristics in both sites are investigated. The wind characteristics during northeast monsoon is found to be favorable for wind energy generation in Mersing with the northeast (0 − 40°) as the prominent wind direction. However, small-scale wind energy is the best option for wind energy development in Mersing. On the other hand, the Port Dickson site demonstrates poor wind characteristics, indicating that this area is not favorable for wind energy development. [ABSTRACT FROM AUTHOR]