Search

In-situ measurements of soil water content provide important constraints on local/global hydrology. We demonstrate that the attenuation of the underground flux of cosmic-ray electromagnetic (EM) particles can be used to monitor the variation of soil water content after rainfalls. We developed a detection system that preferably selects EM particles by considering the coincidence of distant plastic scintillators. The calibration test beneath the water pool revealed that the count rate decreased by 0.6–0.7% with a 1 cm increase in the water level. The field measurement performed in the horizontal tunnel showed that the count rate dropped according to 48-h precipitation, after correcting the effects originating from atmospheric and water vapour pressures. These characteristics were confirmed using dedicated Monte Carlo simulations. This new method is called cosmic electromagnetic particle (CEMP) radiography. [ABSTRACT FROM AUTHOR]

We present a method for classification of the two distinct types of electrical activity that occur during an explosive volcanic eruption: vent discharges and lightning. Vent discharges occur at the onset of an explosion and create a distinctive radio frequency signature called continual radio frequency. Seconds to minutes after the onset of the eruption, lightning begins to occur throughout the eruption column. We use logistic regression to classify a radio frequency impulse as being part of either a lightning flash or a period of continual radio frequency. The classifier uses the number of peaks in the amplitude envelope from 1 ms windows before and after the impulsive very high frequency waveform, with an average accuracy of 97.9%. We propose that this method could be used in an algorithm to determine when explosive eruptions occurred by identification of the distinctive signatures of vent discharges and lightning. Plain Language Summary: We present a method for automated identification of two distinct types of electrical activity from explosive volcanic eruptions. Explosive eruptions produce lightning, just like thunderstorms. In addition, they also produce small (<4 m) spark‐like electrical discharges at the vent of a volcano, which are called vent discharges. These vent discharges occur for relatively long durations compared to the duration of a typical lightning flash (seconds vs. hundreds of milliseconds) and are thus easily distinguishable in very high frequency (30–300 MHz) electric field measurements. We use logistic regression to classify an electric field impulse as either being part of a lightning flash or a vent discharge. The classifier uses the number of peaks in the electric field signal in 1 ms time windows before and after an electric field impulse. The accuracy of the classifier is 97.9%. We explain that the classifier could be used on a low‐power lightning sensor to automatically identify that an explosive eruption had occurred. We discuss how this capability would enable a new era of volcanic lightning monitoring that would allow for new research into understanding the physical mechanisms of vent discharges to learn how they can be used during the response to an eruption. Key Points: We created a logistic regression model that classifies electrical activity as either vent discharges or lightning with an accuracy of 97.9%The logistic regression model uses the number of waveform peaks in 1 ms time windows preceding and succeeding an RF impulseThe model could be used to identify the characteristic pattern of electrical activity produced by explosive eruptions [ABSTRACT FROM AUTHOR]

A hydrophobic sphere, freely released from a certain height, entering water makes a cavity behind it. This paper visually demonstrates underwater sound produced by the water entry with the use of a hydrophone synchronized with a high-speed camera. The acoustic signal of the underwater sound recorded can be found to include two predominant frequencies. A remarkable finding is the fact that the higher predominant frequency sound can be excited by the breathing mode of a residual bubble behind the sphere after the cavity pinching off. In addition, the lower frequency sound is predicted to be driven by the oscillation of the free surface caused by the impact of the sphere. [ABSTRACT FROM AUTHOR]

Characterizing the size and settling velocity of pyroclastic fragments injected into the atmosphere during volcanic eruptions (i.e., tephra) is crucial to the forecasting of plume and cloud dispersal. Optical disdrometers have been integrated into volcano monitoring networks worldwide in order to best constrain these parameters in real time. Nonetheless, their accuracy during tephra fallout still needs to be assessed. A significant complication is the occurrence of particle aggregates that modify size and velocity distributions of falling tephra. We made the first use of the Thies Clima Laser Precipitation Monitor (LPM) for tephra-fallout detection at Sakurajima volcano (Japan), which is characterized by a lower size detection window with respect to more commonly used disdrometers (e.g., Parsivel2) and can more easily distinguish different falling objects. For the first time, individual particles have been distinguished from most aggregates based on disdrometer data, with the potential to provide useful grain-size information in real time. In case of negligible aggregation, LPM and collected sample-based estimates are in agreement for both grain-size and sedimentation rate. In case of significant aggregation, particle shape analyses and a dedicated drag equation are used to filter out aggregates from LPM data that also provide good agreement with collected tephra samples. [ABSTRACT FROM AUTHOR]

Characterizing the size and settling velocity of pyroclastic fragments injected into the atmosphere during volcanic eruptions (i.e., tephra) is crucial to the forecasting of plume and cloud dispersal. Optical disdrometers have been integrated into volcano monitoring networks worldwide in order to best constrain these parameters in real time. Nonetheless, their accuracy during tephra fallout still needs to be assessed. A significant complication is the occurrence of particle aggregates that modify size and velocity distributions of falling tephra. We made the first use of the Thies Clima Laser Precipitation Monitor (LPM) for tephra-fallout detection at Sakurajima volcano (Japan), which is characterized by a lower size detection window with respect to more commonly used disdrometers (e.g., Parsivel2) and can more easily distinguish different falling objects. For the first time, individual particles have been distinguished from most aggregates based on disdrometer data, with the potential to provide useful grain-size information in real time. In case of negligible aggregation, LPM and collected sample-based estimates are in agreement for both grain-size and sedimentation rate. In case of significant aggregation, particle shape analyses and a dedicated drag equation are used to filter out aggregates from LPM data that also provide good agreement with collected tephra samples. [ABSTRACT FROM AUTHOR]

Aggregation of volcanic ash is known to significantly impact sedimentation from volcanic plumes. The study of particle aggregates during tephra fallout is crucial to increase our understanding of both ash aggregation and sedimentation. In this work, we describe key features of ash aggregates and ash sedimentation associated with eleven Vulcanian explosions at Sakurajima Volcano (Japan) based on state-of-the-art sampling techniques. We identified five types of aggregates of both Particle Cluster (PC) and Accretionary Pellet (AP) categories. In particular, we found that PCs and the first and third type of APs can coexist within the same eruption in rainy conditions. We also found that the aerodynamic properties of aggregates (e.g., terminal velocity and density) depend on their type. In addition, grainsize analysis revealed that characteristics of the grainsize distributions (GSDs) of tephra samples correlate with the typology of the aggregates identified. In fact, bimodal GSDs correlate with the presence of cored clusters (PC3) and liquid pellets (AP3), while unimodal GSDs correlate either with the occurrence of ash clusters (PC1) or with the large particles (coarse ash) coated by fine ash (PC2). [ABSTRACT FROM AUTHOR]

Volcanic plumes from small and moderate eruptions represent a challenge in the study of plume morphology due to eruption source parameter uncertainties and atmospheric influence. Sakurajima volcano, Japan, features such activity and due to its continuous eruptions in the recent years provides an ideal natural laboratory. A data set of 896 eruptions between 2009 and 2016 with well‐constrained plume heights, estimated erupted mass, and associated atmospheric conditions has been compiled. Plume heights ranged between 1,500 and 5,000 m and mainly developed under stable atmospheric stratification and low background wind speeds. The eruptions presented in the database were used to drive FPLUME, a 1‐D integral volcanic plume model, to study the simulated plume morphology. FPLUME was seen to provide consistent results under stable atmospheric stratification. A method for the real‐time monitoring of erupted mass used in the Sakurajima observatory was seen to provide appropriate first guess estimates for the eruptions, showing agreement with analytical and simulated mass flow rate calculations. Volcanic plumes from Sakurajima show significant influence by the atmospheric environment. The plume scaling parameter (Π) was used to characterize the expected degree of plume bending with results correlating well against modeled plume angles. The vertical wind profile was seen to have a significant impact on the resolved plume. Wind shear characteristics were seen to have a mechanical effect on the plume, aiding or inhibiting bending. Finally, potential issues were identified in simulations under unstable atmospheric conditions as the model either failed to provide a solution or overestimated the plume height. Key Points: A database of 896 eruptions from Sakurajima with associated atmospheric profiles is presentedDifferent plume bending regimes are quantitatively evaluated using the FPLUME modelVertical wind shear mechanically affects plume morphology by aiding or inhibiting plume bending [ABSTRACT FROM AUTHOR]

The catalytic activity of a homogeneous iridium complex in formic acid disproportionation into methanol was explored. Formic acid reduction to methanol proceeds efficiently in aqueous media with the methanol yield depending on the nature of the solvent, substrate concentration, applied H2 pressure and reaction temperature. The methanol yield peaked at 75% when D2O was used as a solvent at 50 °C. Increasing the reaction temperature to 80 °C and doubling the substrate concentration led to an improved methanol concentration, even though the corresponding yield dropped to 59%. Initial H2 pressures further enhanced methanol formation, affording a highly concentrated 9.8 m methanol solution or a TON of 1260 upon in situ catalyst recycling under aerobic conditions. No catalyst deactivation was observed for five cycles. [ABSTRACT FROM AUTHOR]

Opposite undamaged nucleotide T, DNA polymerase ι (Polι) preferentially incorporates G rather than A, violating the Watson-Crick rule. Although the actual biological role of Polι remains enigmatic, we have identified its coding gene as a candidate for pulmonary adenoma resistance 2 (Par2), a mouse quantitative trait locus modulating chemically induced lung tumor susceptibility. Notably, the most tumor-sensitive Par2 allele possessed by the 129X1/SvJ mouse is associated with a loss-of-function mutation in Polι. To determine whether the nonfunctional Polι is responsible for the 129X1/SvJ-specific Par2 phenotype, we knocked out Polι in a C57BL/6J mouse carrying a less tumor-sensitive Par2 allele. Disruption of the C57BL/6J Polι conferred 129X1/SvJ-like sensitivity on the C57BL/6J Par2 locus and increased the in vivo mutation frequency in the lung, providing definitive proof that Polι causes the Par2 effect and inhibits tumorigenesis and mutagenesis, despite its extreme replication infidelity. [ABSTRACT FROM AUTHOR]

The optimization of the heat treatment of \Nb3\Sn conductors for toroidal field coils in ITER was attempted to improve the current sharing temperatures (Tcs). Using the strand, we chose the pattern at 570  ^\circ\C for 250 h and 650  ^\circ\C for 100 h as the best, which increased the critical current and maintained the residual resistivity ratio higher than 100. The behavior of the critical current of the strand vs. the magnetic field, temperature, and strain was also improved. This pattern was used on two conductors, and their performances were tested. Tcs was evaluated over 1000 electromagnetic cycles and one thermal cycle. A sharp Tcs degradation occurred at 50 cycles. Then Tcs decreased linearly. Although this tendency was similar to the conductors that were heat treated with the original pattern, the degradation rates were improved. The ac losses (Q) before cycling were approximately 10% lower than those of the original pattern. Q after cycling became almost equivalent between two patterns. The conductor was inspected after the test, which showed that the conductor under the high-magnetic-field zone had contracted by approximately 600 ppm during the test. Some clearly deformed strands were observed under the high-magnetic-field zone, which could degrade Tcs. [ABSTRACT FROM PUBLISHER]

The performance of four \Nb3\Sn conductors for the ITER central solenoids was tested. The current sharing temperatures (Tcs) were measured over approximately 9000 electromagnetic cycles, including two or three thermal cycles between 4.2 K and room temperature. Tcs increased and became almost constant through the cycling. The gradient of the electric field against the temperature gradually decreased against cycling. The degradations caused by the electromagnetic force of the short twist pitch conductors were smaller than that of the original twist pitch conductor. The ac losses of short twist pitch conductors were several times higher than that of original twist pitch conductor. The dents and the removals of the Cr plating on the strands, which were formed during cabling, decreased the electric resistance between strands, which may cause the observed high ac loss. Inspection of the cable showed neither a clear bias of cable in the cross-sectional surface nor distorted strands in the lateral face. The high rigidity of the short twist pitch cable could prevent these plastic deformations, caused by the Lorentz force. [ABSTRACT FROM PUBLISHER]

The long-time viscous flow about two identical rotating circular cylinders in a side-by-side arrangement is investigated using an adaptive numerical scheme based on the vortex method. The Stokes solution of the steady flow about the two-cylinder cluster produces a uniform stream in the far field, which is the so-called Jeffery’s paradox. The present work first addresses the validation of the vortex method for a low-Reynolds-number computation. The unsteady flow past an abruptly started purely rotating circular cylinder is therefore computed and compared with an exact solution to the Navier–Stokes equations. The steady state is then found to be obtained for $t\gg 1$ with ${\mathit{Re}}_{\omega } {r}^{2} \ll t$, where the characteristic length and velocity are respectively normalized with the radius ${a}_{1} $ of the circular cylinder and the circumferential velocity ${\Omega }_{1} {a}_{1} $. Then, the influence of the Reynolds number ${\mathit{Re}}_{\omega } = { a}_{1}^{2} {\Omega }_{1} / \nu $ about the two-cylinder cluster is investigated in the range $0. 125\leqslant {\mathit{Re}}_{\omega } \leqslant 40$. The convection influence forms a pair of circulations (called self-induced closed streamlines) ahead of the cylinders to alter the symmetry of the streamline whereas the low-Reynolds-number computation (${\mathit{Re}}_{\omega } = 0. 125$) reaches the steady regime in a proper inner domain. The self-induced closed streamline is formed at far field due to the boundary condition being zero at infinity. When the two-cylinder cluster is immersed in a uniform flow, which is equivalent to Jeffery’s solution, the streamline behaves like excellent Jeffery’s flow at ${\mathit{Re}}_{\omega } = 1. 25$ (although the drag force is almost zero). On the other hand, the influence of the gap spacing between the cylinders is also investigated and it is shown that there are two kinds of flow regimes including Jeffery’s flow. At a proper distance from the cylinders, the self-induced far-field velocity, which is almost equivalent to Jeffery’s solution, is successfully observed in a two-cylinder arrangement. [ABSTRACT FROM PUBLISHER]

The performances of six Nb3Sn conductors for the ITER Toroidal Field coils were tested. Four of them showed similar degradation rates of their current sharing temperatures Tcs over 1,000 electromagnetic cycles. By contrast, two of them showed sharp Tcs degradations at 50 cycles, after which their slopes became similar to those of the other four conductors. These two cables seemed to shrink under high magnetic fields during the first 50 cycles, which caused the sharp Tcs degradation. This shrinkage might arise from a decline in cable rigidity due to, for example, the deformation of strands or the breakage of the Nb3Sn filaments. The four mass-produced conductors had roughly the same AC loss before cycling. After 1,000 cycles, the AC losses of all the conductors decreased markedly to less than half of those before cycling, and the values became approximately the same. After the test campaign, the destructive inspection of two of the conductors made it clear that the conductor had shrunk by about 520 ppm under the high magnetic field during the test. It was also clarified that some strands were visibly deformed under the high magnetic field, whereas those under the low magnetic field did not look distorted. This plastic deformation of the strands could be one of the major reasons for the Tcs degradation with cyclic operation. [ABSTRACT FROM PUBLISHER]

JAEA has conducted qualification and rationalization activities in Japan since March 2009 in order to rationalize manufacturing procedure of ITER toroidal field coil (TFC) structures. These following activities has been performed: qualification of structural materials and qualification and development of welding procedure according to the JSME code constituted for fusion devices, demonstration of the manufacturing method and procedures through manufacture of 1 m mock-ups and full-scale segments of TFC structure. From results of these activities, JAEA confirmed quality of materials and weld joints of gas tungsten arc welding and gas metal arc welding. In addition, JAEA obtained knowledge of welding deformation of actual TFC structures. This paper describes results of these qualification and development activities for ITER TFC structure. [ABSTRACT FROM PUBLISHER]

Japan Atomic Energy Agency (JAEA) started sub- and full-scale trials to qualify and optimize manufacturing procedure of ITER TF coil from March 2009 under the contract with Toshiba. As major outcome of these trials, feasibility of high accuracy of winding, prediction of the conductor elongation due to heat treatment and radial plate manufacture is confirmed. Therefore, JAEA can mostly establish manufacturing plan for the TF coil and then, start the first TF coil procurement from 2013, following to full demonstration through manufacturing a dummy double-pancake in 2012. [ABSTRACT FROM PUBLISHER]

The mass transfer between immiscible two-liquid phases can be greatly enhanced by bubbling gas through a reactor. Numerous micro water droplets breaking out from a ruptured water film around a rising bubble through the oil (upper phase)/water (lower phase) interface were demonstrated in the preceding paper (Uemura et al. in Europhys Lett 92:34004, ). In this study, we attempt to oppositely charge the oil and water layers, taking into account the findings of the preliminary study (Uemura et al. in J Vis 13:85, ). As a result, this study successfully produces more and finer water droplets than the preceding experiments. Graphical Abstract: Graphical Abstract text [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Background and Aims: The results of a phase III, placebo-controlled study demonstrated that endoscopic direct spraying of L: -menthol onto the gastric mucosa effectively suppressed gastric peristalsis in the study patients. The aim of the study reported here was to determine whether the anti-peristaltic effect of an L: -menthol preparation facilitates endoscopic examinations in a clinical setting.Methods: This was a multicenter, open-label, single-arm trial in which the study cohort comprised patients in whom L: -menthol was likely to be used to facilitate endoscopic examination in clinical settings. The primary outcome was the proportion of subjects with no peristalsis (Grade 1) after treatment and at the end of endoscopy (defined as the complete suppression of gastric peristalsis). This variable was assessed according to the level of anti-Helicobacter pylori immunoglobulin G (IgG) antibody, pepsinogen test results, whether sedation was performed, and whether subjects were considered unsuitable for the use of conventional antispasmodics.Results: Of the 119 enrolled subjects, data from 112 were included in the primary efficacy analysis. Gastric peristalsis was completely suppressed in 37.5% of the patients [42/112 patients; 95% confidence interval (CI) 28.5-47.1]. Subgroup analyses revealed that the rate of peristalsis suppression was significantly higher in patients with elevated levels of anti-H. pylori IgG antibody (26/44, 59.1%; 95% CI 43.2-73.7); P < 0.001] and positive pepsinogen test results (21/35, 65.6%; 95% CI 46.8-81.4; P < 0.001]. There was no significant difference according to sedation (17/52, 32.7%; 95% CI 20.3-47.1; P = 0.434) or whether subjects were considered unsuitable for use of conventional antispasmodic agents (14/28, 50.0%; 95% CI 30.6-69.4; P = 0.12].Conclusion: These findings are comparable to those of the phase III placebo-controlled study and provide further evidence that endoscopic direct spraying of L: -menthol effectively suppresses gastric peristalsis during upper gastrointestinal endoscopy. [ABSTRACT FROM AUTHOR]

Objectives:We investigated the correlation between Japanese apricot (JA) intake and Helicobacter pylori-related chronic atrophic gastritis (CAG).Methods:A questionnaire was administered and serum anti-H. pylori IgG antibodies measured in 1358 asymptomatic adults. The subjects were divided into high-intake and low-intake groups. Histological and serological evaluation of H. pylori-related CAG was performed in 68 non-elderly volunteers.Results:The H. pylori-negative rate did not differ significantly between the high-intake and low-intake groups. Mean antibody titers were lower in the high-intake group, but the difference was not significant. There was no significant difference in the rate of H. pylori infection on the basis of JA intake when subjects were stratified by age. Among H. pylori-positive non-elderly subjects, antibody titers were significantly lower in the high-intake group (P=0.041). Endoscopic tissue biopsy from the 68 volunteers showed less H. pylori bacterial load and mononuclear infiltration irrespective of gastric site in the high-intake group. In the high-intake group, antral neutrophil infiltration was significantly less pronounced and corporal atrophy was less extensive. Serological evaluation using serum PG levels also confirmed these histopathological data.Conclusions:Our findings strongly indicate a preventive effect of JA intake on CAG by inhibiting H. pylori infection and reducing active mucosal inflammation. [ABSTRACT FROM AUTHOR]

Flow past a square prism with cut-corners at the front-edge is numerically and experimentally visualized to investigate a mechanism of drag reduction. An adaptive numerical scheme based on the vortex method is implemented for two values of the Reynolds number between 200 and 1,250, and the results are compared with experiments. Experimental visualization techniques include the hydrogen-bubble technique at Re=4,000 and the oil-flow technique at Re=10,000 for a global wake formation, and the aluminum-flake technique for transient flow at the early stage of motion at Re=1,250. A similar reattachment flow pattern is shown in a wide range of the Reynolds number between 200 and 10,000, which implies a possibility of the drag reduction in the Reynolds number being approximately lower than 8,000 unlike the previous findings. [ABSTRACT FROM AUTHOR]

Jet-induced rotary sloshing of a Newtonian fluid in a partially filled cylindrical container is numerically and experimentally visualized to investigate a flow pattern inside the rotary sloshing wave. Visualization techniques employed in this study include Computational Fluid Dynamics (CFD) and Particle Image Velocimetry (PIV). Result for the sloshing period is compared with the theoretical result of a small time-harmonic irrotational flow of an inviscid and incompressible fluid, and several results for 3D view of the rotary sloshing and the velocity vector in the vertical and horizontal cross-sections are given. [ABSTRACT FROM AUTHOR]

Background: We have previously shown that the intraluminal concentration of NO in H. pylori -positive patients is significantly reduced compared to that in H. pylori -negative patients. Aim: The aim of this study was to evaluate the effect of H. pylori infection on gastric motor activity in relation to the level of NO and nitrite in the stomach in humans. Methods: Thirty-two H. pylori -negative and 32 H. pylori -positive patients with dyspepsia were studied. Gastric myoelectrical activity was recorded for 24 h using surface electrogastrography. Intraluminal gas and juice were endoscopically collected from the stomach to determine NO and nitrite and nitrate (NOx) levels using a chemiluminescence system. Results: The percentage of tachygastria in the morning preprandial state was significantly higher (P =0.005) in H. pylori -positive than -negative patients. In H. pylori -negative patients, there was a significant positive correlation between NO levels and the percentage of bradygastria (r =0.56, P =0.001) and a significant negative correlation between NOx levels and the percentage of normal electrical activity (r =- 0.57, P =0.001) in the preprandial state. Conclusions: Gastric motor activity is associated with NO and NOx levels in the gastric lumen. H. pylori infection may play a role in the pathogenesis of abnormal gastric myoelectrical activity. [ABSTRACT FROM AUTHOR]

Osteopontin (OPN) is a urinary protein which inhibits calcium oxalate (CaOx) crystal growth in the seed crystal system. The aim of this study was to evaluate the effects of OPN immobilized on collagen granules (CG) for CaOx crystal growth and aggregation in this system. OPN-immobilized CG showed a 30% decrease in inhibitory activity compared with non-OPN-immobilized CG. Scanning electron microscopy revealed that 1) OPN-immobilized CG showed more marked aggregation and adhesion of seed crystals (smaller than 0.5 µm in diameter) than non-OPN-immobilized CG, 2) the amount of adherent large type crystals (2–3 µm in diameter) did not differ between OPN immobilized and non-OPN-immobilized CG. In conclusion, immobilized OPN promotes aggregation and adhesion of CaOx crystals smaller than 0.5 µm on CG. These observations suggest that crystal adhesion to immobilized OPN plays a role in the retention of crystals in the kidney. [ABSTRACT FROM AUTHOR]

Most particle-tracking velocimetry (PTV) algorithms are not suitable for calculating the velocity vectors of a fluid flow subjected to strong deformation, because these algorithms deal only with flows due to translation. Accordingly, it is necessary to develop a novel algorithm applicable to flows subjected to strong deformations such as rotation, shear, expansion and compression. This paper proposes a novel particle tracking algorithm using the velocity gradient tensor (VGT) which can deal with strong deformations and demonstrates that this algorithm is applicable to some basic fluid motions (rigidly rotating flow, Couette flow, and expansion flow). Furthermore, the performance of this algorithm is compared with the binary image cross-correlation method (BICC), the four-consecutive-time-step particle tracking method (4-PTV), and the spring model particle tracking algorithm (SPG) using simulations and experimental data. As a result, it is shown that this novel algorithm is useful and applicable for the highly accurate measurement and analysis of fluid flows subjected to strong deformations. [ABSTRACT FROM AUTHOR]

Background: Nitric oxide (NO) plays an important role in gastrointestinal mucosal protection. We have previously shown that Helicobacter pylori infection is associated with a lower concentration of NO in the human stomach. The aim of this study is to explore the pathogenesis of this finding using an animal model. Methods: Mongolian gerbils were divided into four groups: H. pylori-negative and -positive, each with and without the intraperitoneal addition of superoxide dismutase (SOD). Intraluminal NO and serum nitrate were measured by using a chemiluminescence system. Inducible nitric oxide synthase (iNOS) levels in gastric mucosa were measured by using the NOSdetect Assay Kit. Results: iNOS levels in H. pylori-positive gerbils were significantly greater than in those without infection. Intraluminal NO levels in H. pylori-positive gerbils were significantly lower than those in H. pylori-negative ones and increased after SOD administration. Serum nitrate levels in H. pylori-positive gerbils were significantly greater than those in H. pylori negative ones and decreased after SOD administration. Conclusions: The low level of NO in the gastric lumen in H. pylori infection is likely a result of superoxide production related to H. pylori-induced inflammation. [ABSTRACT FROM AUTHOR]

We previously reported the importance of osteopontin (OPN) in the formation of urinary calculus. Since OPN protein is present in normal kidneys, we investigated the difference in OPN at the DNA level between normal subjects and urolithiasis patients. There has not been any genetic investigation of OPN in familial urolithiasis previously reported worldwide. To confirm hereditary predisposing factors for urolithiasis, changes in OPN DNA within a family were investigated in relation to the presence or absence of urinary calculus. Leukocyte OPN DNA from two normal subjects and five patients with urinary calculus was investigated by SSCP analysis: OPN DNA nucleotide sequence was determined, based on the result of SSCP analysis. As a result, a mutation of GCC to GCT, encoding amino acid position 250 (Ala-250) was found. To confirm the frequency of mutation at this site, OPN DNA was extracted from peripheral blood in 36 normal subjects (Con group), 25 patients with familial urolithiasis (FSF), and 40 patients with recurrent urinary calculus and who had had two or more previous episodes (RSF). The degree of mutation at Ala-250 was then examined by restriction fragment length polymorphism (RFLP) method. As described above, the nucleotide codon encoding the amino acid sequence position 250, Ala-250, was GCC in two normal subjects. This is the original codon. In five patients with urolithiasis it was GCT, showing a substitution of C with T. On examining the frequency of this mutation, the ratio of normal homozygous GCC was 11/36 in the Con group, 1/25 in FSF and 1/40 in RSF. The ratio of heterozygous GCC/GCT was 16/36 in the Con group, 15/25 in FSF and 26/40 in RSF, and the ratio of homozygous GCT was 9/36 in the Con group, 9/25 in FSF and 13/40 in RSF. Furthermore, the gene frequency of the normal codon GCC was 0.528 in the Con group, 0.3 in FSF and 0.35 in RSF, showing a significantly higher incidence in the Con group (P < 0.05). The gene frequency of mutated GCT was 0.472 in Con group, 0.7 in FSF and 0.65 in RSF, showing a significantly higher incidence in urolithiasis patients (P < 0.05). On investigating the inheritance of Ala-250 in five families in which both parent and offspring demonstrated urolithiasis, the nucleotide substitution in Ala-250 in parents with urolithiasis was inherited by their offspring. In all five families the offspring developed urinary calculus. This study showed that there is no difference in OPN structure between the Con group and urolithiasis patients. However, it was predicted that due to the frequency of normally coded GCC being high in the Con group a difference in the amount of OPN might be caused by a difference in transcription velocity between the two groups. Furthermore, it was suggested that examining the inheritance of Ala-250 within a family is a diagnostic method for identifying the predisposing hereditary factors for urolithiasis patients. [ABSTRACT FROM AUTHOR]

We introduce a theoretical basis of polarization mode dispersion (PMD) equalizers based on the operator representation of PMD using Taylor's expansion. The two types of configuration of PMD equalizers are derived as the inverse of diagonalization operators and delay time difference compensation. One is a type using physical rotation of quarter wave phase plates. The other is a type using variable phase shifters suitable for PLC integration. Waveform comparison algorithm was simulated to show the existence of multiple equivalent optimum points due to the symmetry and periodicity of optical circuits. The second order PMD equalization is discussed briefly on the case of cascading the first and the second PMD equalizing circuits with two different polarization state converters [ABSTRACT FROM PUBLISHER]

High-resolution transmission electron microscopy and conventional transmission electron microscopy have been used to investigate in detail the transformation processes of twinned 9R copper precipitates to final stable structures via a 3R structure in a thermally aged Fe-Co model alloy. In 9R precipitates of size greater than about 13nm, the motion of the twin boundaries and the elimination of the regular stacking faults on every third (009)[sub 9R] close packed plane were observed to occur nearly simultaneously. Direct evidence was found that 3R is a non-cubic structure obtained when the regular stacking faults on the (009)[sub 9R] basal planes are removed. In larger precipitates (of size up to about 26 nm), lattice plane rotations and plane spacing changes in 3R variants took place towards stable fcc and fct structures, suggesting the occurrence of lattice relaxation involving the diffusion of atoms. The fct structure had larger lattice constants a=b=0.369 nm and c=0.366 nm than bulk fcc copper (a=0.361 nm). Precipitates of size 26-40 nm consisted of nearly twin-related variants with both fcc and fct segments, and aligned with the iron matrix according to the Kurdjumov-Sachs orientation relationship. Larger precipitates were observed to be fcc and fct single crystals. [ABSTRACT FROM AUTHOR]

Ever since its remarkable mechanical properties were found fifteen years ago, interest has grown in bacterial cellulose for which the use had been more or less limited to the manufacture of nata-de-coco, an indigenous food of South-East Asia. This paper reviews the progress of relevant studies including the production of cellulose by bacteria, the formation of microfibrils and gel layer, the properties of gel and processed sheets, and some aspects of applications. [ABSTRACT FROM AUTHOR]