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Elaborating and understanding disparities in the burden of cardiovascular disease attributable to high fasting plasma glucose is important to improve diabetes prevention and promote cardiovascular health. In this study, we pool data on 791,373 people aged 25 years and older from three population-based surveys, and estimate the burden of cardiovascular disease attributable to high fasting plasma glucose between 2010 and 2018 in China by age, sex, region and socio-demographic index. In 2018, an estimated total of 498.61 thousand (95% uncertainty interval 463.93 to 534.12) cardiovascular disease-related deaths are attributable to high fasting plasma glucose in China. High fasting plasma glucose accounts for 1076.09 years of life lost per 100,000 people (95% uncertainty interval 1026.88–1129.04) due to cardiovascular disease in 2018, with substantial variation across provinces. In 2018, the higher age-standardised cardiovascular disease mortality rate attributable to high fasting plasma glucose is observed in the high-middle socio-demographic index region and the middle socio-demographic index region. Nationally, compared to 2010, exposure to high fasting plasma glucose and population aging in 2018 are the primary drivers of increased fasting plasma glucose-related deaths due to cardiovascular disease. Findings of this study emphasize the importance of developing population-specific tailored measures in China and other regions with similar condition. Evidence for comprehensive assessment of cardiovascular disease (CVD) burden attributable to high fasting plasma glucose (FPG) in China is limited. Here, the authors show CVD deaths attributable to high FPG varied substantially across China. Exposure to high FPG and population aging were the primary drivers of increased CVD burden. [ABSTRACT FROM AUTHOR]

CO2 hydrogenation into valuable chemical compounds can effectively address the issues of greenhouse gas emissions and energy scarcity. The activation and dissociation processes of CO2 are crucial for its reduction reactions, but the effects of *H adatoms on the C–O cleavage are still confusing. This study investigates the H-assisted CO2 dissociation pathways on the PdnPt(4−n)/In2O3 (n = 0–4) catalysts via DFT calculation. Initially, the adsorption properties of *H2, *COOH, and *HCOO species are calculated. Then, two H-assisted CO2 dissociation channels, i.e., *CO2 + *H → *COOH → *CO + *OH and *CO2 + *H → *HCOO → *CHO + *O, are studied. Results show that Pt and Pd promote the CO2 hydrogenation and C–O bond cleavage reactions, respectively. In comparison to CO2 direct dissociation, the COOH-mediated and HCOO-mediated channels facilitate and impede the C–O bond cleavage, respectively. Overall, the Pd3Pt/In2O3 constituent is suggested for the H-assisted CO2 dissociation reaction. The electronic effects of the PdnPt(4−n) bimetals adjust the stabilities of the intermediates and barriers of the elementary steps, and the interactions between PdnPt(4−n) and In2O3 provide extra sites for the adsorbates and reaction steps. This study reveals the effects of *H on the C–O bond dissociation processes and provides useful insight into designing PdPt/In2O3 catalysts for CO2 hydrogenation reactions. [ABSTRACT FROM AUTHOR]

Monoisotopic-boron-enriched hexagonal boron nitride (hBN) has a higher thermal conductivity (10B- or 11B-enriched), larger phonon lifetime (10B- or 11B-enriched) and stronger neutron absorption cross-section (10B-enriched) than the natural, non-isotopic-enriched hBN counterpart. These features make monoisotopic hBN highly desirable for application in neutron detectors, nanoscale electronics, and optical components. Herein, we synthesized monoisotopic hBN single crystals (SCs) using isotope-enriched boric acid based on the atmospheric-pressure high-temperature (APHT) method. X-ray diffraction measurements indicated that the monoisotopic hBN SCs were well-crystallized. Detailed Raman measurements verified the high crystal quality and uniformity. The dependency of the Raman peak position and peak width on the isotope content was also observed, matching well with theoretical calculations. In the cathodoluminescence spectra, the presence of a longitudinal optical (LO) phonon-related emission at around 5.75 eV was also indicative of the high quality of the crystals. Thus, our results present a low-cost route for the synthesis of high-quality monoisotope-enriched hBN single crystals. [ABSTRACT FROM AUTHOR]

Given that input-based language and literacy environments provide socioculturally-enriched contexts for bilingual and biliteracy acquisition, the current study aims to explore the contribution of early input in various sociocultural contexts to later biliteracy development among -college-level Chinese heritage language (CHL) students. A group of CHL students (N = 195) participated in this study and completed a background survey about their early oral and print experiences in different sociocultural contexts. Biliteracy measurements including Chinese-English bilingual morphological awareness and reading ability were administered to the participants. Drawing on multivariate analyses, the study verified both intralingual and interlingual contributions of input-based experiences to biliteracy development. The study suggests that (1) community and after-school language and literacy support can have a long-term impact on the maintenance of heritage language literacy skills. (2) heritage language input experiences do not create obstacles for dominant language literacy development. (3) heritage language literacy input provides facilitations for the abstraction of bilingual structures and units. [ABSTRACT FROM AUTHOR]

Herein, the effect of fluoropolymer binders on the properties of polymer-bonded explosives (PBXs) was comprehensively investigated. To this end, fluorinated semi-interpenetrating polymer networks (semiIPNs) were prepared using different catalyst amounts (denoted as F23-CLF-30-D). The involved curing and phase separation processes were monitored using Fourier-transform infrared spectroscopy, differential scanning calorimetry, a haze meter and a rheometer. Curing rate constant and activation energy were calculated using a theoretical model and numerical method, respectively. Results revealed that owing to its co-continuous micro-phase separation structure, the F23-CLF-30-D3 semi-IPN exhibited considerably higher tensile strength and elongation at break than pure fluororubber F2314 and the F23- CLF-30-D0 semi-IPN because the phase separation and curing rates matched in the initial stage of curing. An arc Brazilian test revealed that F23-CLF-30-D-based composites used as mock materials for PBXs exhibited excellent mechanical performance and storage stability. Thus, the matched curing and phase separation rates play a crucial role during the fabrication of high-performance semi-IPNs; these factors can be feasibly controlled using an appropriate catalyst amount. [ABSTRACT FROM AUTHOR]

The utilization of dredged sediment (DS) as a transformative material in building applications presents an ideal consumption strategy. This study endeavors to create a novel ceramsite lightweight aggregate (LWA) through the co-sintering of DS and rice husks (RHs), further integrating this LWA into the construction of pervious concrete. Results revealed that the optimum production procedure for the DS-based LWA incorporated a 21% RH addition, a sintering temperature of 1100 °C, and a sintering duration of 21 min. Notably, the optimal ceramsite LWA, denoted as SDC-H, exhibited a cylinder compressive strength of 28.02 MPa and an adsorption efficiency for Pb2+ of 94.33%. Comprehensive analysis (encompassing bulk density, cylinder compressive strength, water absorption, and the leaching concentrations of heavy metals) confirmed that SDC-H impacted the specification threshold of high-strength light aggregate derived from solid waste (T/CSTM 00548-2022). Substituting 50% of SDC-H led to a diminution in the mechanical properties but an improvement in the dynamic adsorption capacity of the innovative pervious concrete, registering a mechanical strength of 26.25 MPa and a cumulative adsorption capacity for Pb2+ of 285 mg/g. These performances of pervious concrete containing 50% SDC-H might correlate with the evolution of an interconnected and open-pore structure. [ABSTRACT FROM AUTHOR]

Purpose: The significant global burden of endometrial cancer (EC) and the challenges associated with predicting EC recurrence indicate the need for a dynamic prediction model. This study aimed to propose nomograms based on clinicopathological variables to predict recurrence-free survival (RFS) and overall survival (OS) after surgical resection for EC. Methods: This single-institution retrospective cohort study included patients who underwent surgical resection for EC. Web-based nomograms were developed to predict RFS and OS following resection for EC, and their discriminative and calibration abilities were assessed. Results: This study included 289 patients (median age, 56 years). At a median follow-up of 51.1 (range, 4.1–128.3) months, 13.5% (39/289) of patients showed relapse or died, and 10.7% (31/289) had non-endometrioid tumors (median size: 2.8 cm). Positive peritoneal cytology result (hazard ratio [HR], 35.06; 95% confidence interval [CI], 1.12–1095.64; P = 0.0428), age-adjusted Charlson comorbidity index (AACCI) (HR, 52.08; 95% CI, 12.35–219.61; P < 0.001), and FIGO (Federation of Gynecology and Obstetrics) stage IV (HR, 138.33; 95% CI, 17.38–1101.05; P < 0.001) were predictors of RFS. Similarly, depth of myometrial invasion ≥ 1/2 (HR, 1; 95% CI, 0.46–2.19; P = 0.995), AACCI (HR, 93.63; 95% CI, 14.87–589.44; P < 0.001), and FIGO stage IV (HR, 608.26; 95% CI, 73.41–5039.66; P < 0.001) were predictors of OS. The nomograms showed good predictive capability, positive discriminative ability, and calibration (RFS: 0.895 and OS: 0.891). Conclusion: The nomograms performed well in internal validation when patients were stratified into prognostic groups, offering a personalized approach for risk stratification and treatment decision-making. [ABSTRACT FROM AUTHOR]

Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on antimicrobial protein diversity and functions remains incomplete. Ribonuclease 4 (Rnase4) is a potential antimicrobial protein with no known function in the intestines. Here we find that RNASE4 is expressed in intestinal epithelial cells (IEC) including Paneth and goblet cells, and is detectable in human and mouse stool. Results from Rnase4-deficient mice and recombinant protein suggest that Rnase4 kills Parasutterella to modulate intestinal microbiome, thereby enhancing indoleamine-2,3-dioxygenase 1 (IDO1) expression and subsequently kynurenic and xanthurenic acid production in IECs to reduce colitis susceptibility. Furthermore, deceased RNASE4 levels are observed in the intestinal tissues and stool from patients with IBD, correlating with increased stool Parasutterella. Our results thus implicate Rnase4 as an intestinal antimicrobial protein regulating gut microbiota and metabolite homeostasis, and as a potential diagnostic biomarker and therapeutic target for IBD. Antimicrobial proteins have been implicated in inflammatory bowel disease (IBD). Here the authors report, using both mouse genetic models and human samples, RNASE4 as a potential antimicrobial protein targeting Parasutterella to alter gut microbiota and metabolite homeostasis, impact susceptibility to IBD, and serve as a potential target for IBD therapy. [ABSTRACT FROM AUTHOR]

Background: Psoriasis is a long-term inflammatory skin disease. A novel herbal formula containing nine Chinese herbal medicines, named Inflammation Skin Disease Formula (ISDF), has been prescribed in clinics for decades. Aims: To investigate the efficacy and action mechanisms of ISDF on psoriasis using imiquimod (IMQ) and Interleukin-23 (IL-23)-induced models in mice and reveal the pharmacokinetics profile of ISDF in rats. Methods: Topical administration of IMQ and intradermal injection with IL-23 respectively induced skin lesions like psoriasis on the dorsal area of Balb/c and C57 mice. The mice's body weight, skin thickness, and psoriasis area and severity index (PASI) were assessed weekly. SD rats were used in the pharmacokinetics study and the contents of berberine and baicalin were determined. Results: The PASI scores and epidermal thickness of mice were markedly decreased after ISDF treatment in both models. ISDF treatment significantly decreased the contents of IL-17A and IL-22 in the serum of IMQ- and IL-23-treated mice. Importantly, ISDF markedly downregulated IL-4, IL-6, IL-1β, and tumor necrosis factor α (TNF-α) gene expression, and the phosphorylation of NF-κB p65, JNK, ERKs and MAPK p38 in IMQ-treated mice. The protein phosphorylation of Jak1, Jak2, Tyk2 and Stat3 was significantly mitigated in the ISDF-treated groups. The absorption of baicalin and berberine of ISDF through the gastrointestinal tract of rats was limited, and their distribution and metabolism in rats were also very slow, which suggested ISDF could be used in the long-term application. Conclusions: ISDF has a strong anti-psoriatic therapeutic effect on mouse models induced with psoriasis through IMQ and IL-23, which is achieved by inhibiting the activation of the Jak/Stat3-activated IL-23/Th17 axis and the downstream NF-κB signalling and MAPK signalling pathways. ISDF holds great potential to be a therapy for psoriasis and should be further developed for this purpose. [ABSTRACT FROM AUTHOR]

In terahertz (THz) photodetection, the efficient interaction between light and matter is crucial for enhancing material properties in nonequilibrium states. This work introduces an innovative approach using spiral plasmonic architectures to effectively control inversion‐symmetry coupling, promoting the operational efficiency of light‐induced hot‐carrier effects in the THz band. The strategic design of the spiral structures, focusing on chirality and symmetry, enables the successful manipulation of a self‐driven photocurrent, adapting its direction and magnitude as needed. This design facilitates the improvement of THz detectors in terms of sensitivity and responsiveness. Additionally, the integration of asymmetric metallization and black phosphorus in the detectors has achieved noteworthy performance metrics, such as a maximum responsivity of 70.2 V W−1 at 0.30 THz, a fast response time below 6 µs, and a noise‐equivalent power lower than 1.95 × 10−10 W Hz−1/2. Harnessing the potential of light‐induced hot carrier effects and advanced band‐structure engineering, this research offers a pragmatic approach for the development of high‐efficiency THz photodetectors, opening new avenues for applications like remote sensing and rapid imaging. [ABSTRACT FROM AUTHOR]

Autophagy is recognized as a promising therapeutic target for traumatic brain injury (TBI). Crocetin is an aglycone of crocin naturally occurring in saffron and has been found to alleviate brain injury diseases. However, whether crocetin affects autophagy after TBI remains unknown. Therefore, we explore crocetin roles in autophagy after TBI. We used a weight-dropped model to induce TBI in C57BL/6J mice. Neurological severity scoring (NSS) and grip tests were used to evaluate the neurological level of injury. Brain edema, neuronal apoptosis, neuroinflammation and autophagy were detected by measurements of brain water content, TUNEL staining, ELISA kits and western blotting. Crocetin ameliorated neurological dysfunctions and brain edema after TBI. Crocetin reduced neuronal apoptosis and neuroinflammation and enhanced autophagy after TBI. Crocetin alleviates TBI by inhibiting neuronal apoptosis and neuroinflammation and activating autophagy. [ABSTRACT FROM AUTHOR]

This document is a correction notice for an article titled "BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells." The authors acknowledge that the original article contained incorrect figures. The corrected figures show the expression of various types of collagens, staining used to identify chondrogenic and osteogenic differentiation, and BMP2-induced osteochondrogenic differentiation in vivo. The corrected article is now available. The publisher, Springer Nature, remains neutral and does not take a position on jurisdictional claims or institutional affiliations. [Extracted from the article]

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Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority in deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration due to their low biotoxicity, high biocompatibility, rapid clearance, and good modification properties. As the key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role in the construction of donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes the research development of NIR‐II small molecule fluorophores based on BTD derivatives in the field of bioimaging, focusing on molecular design and photophysical properties, and introduces a part of the applications in the biological field. Furthermore, the challenges of BTD‐based NIR‐II fluorophores in the future development and application are discussed. [ABSTRACT FROM AUTHOR]

Carbon source addition is an important way improving the carbon and nitrogen transformation in aquaculture system; however, its effectiveness of algal–bacterial-based aquaponics (AA) through carbon source addition is still vague. In this study, the influences of organic carbon (OC-AA system) and inorganic carbon (IC-AA system) addition and without carbon source addition (C-AA system) on the operational performance of AA system were investigated. Results showed that 10.1–19.5% increase of algal–bacterial biomass enhanced the purifying effect of ammonia nitrogen in OC-AA system and IC-AA system relative to C-AA system. Moreover, extra electron donor supply in the OC-AA system obtained the lowest NO3−-N concentration. However, that was at the cost of aggravated N2O conversion ratio, which increased by more than 2.0-folds than other systems, attributing to 2.9-folds increase of nirS gene abundance. In addition, carbon source addition increased the pH and then decreased the fish biomass production of AA system. The results of this study would provide theoretical supports of carbon source addition on the performance of nutrient transformation and greenhouse gas effect in AA system. [ABSTRACT FROM AUTHOR]

Background: Idiopathic pulmonary fibrosis is a persistent disease of the lung interstitium for which there is no efficacious pharmacological therapy. Protodioscin, a steroidal saponin, possesses diverse pharmacological properties; however, its function in pulmonary fibrosis is yet to be established. Hence, in this investigation, it was attempted to figure out the anti-pulmonary fibrosis influences of protodioscin and its pharmacological properties related to oxidative stress. Methods: A mouse lung fibrosis model was generated using tracheal injections of bleomycin, followed by intraperitoneal injection of different concentrations of protodioscin, and the levels of oxidative stress and fibrosis were detected in the lungs. Multiple fibroblasts were treated with TGF-β to induce their transition to myofibroblasts. It was attempted to quantify myofibroblast markers' expression levels and reactive oxygen species levels as well as Nrf2 activation after co-incubation of TGF-β with fibroblasts and different concentrations of protodioscin. The influence of protodioscin on the expression and phosphorylation of p62, which is associated with Nrf2 activation, were detected, and p62 related genes were predicted by STRING database. The effects of Nrf2 inhibitor or silencing of the Nrf2, p62 and NBR1 genes, respectively, on the activation of Nrf2 by protodioscin were examined. The associations between p62, NBR1, and Keap1 in the activation of Nrf2 by protodioscin was demonstrated using a co-IP assay. Nrf2 inhibitor were used when protodioscin was treated in mice with pulmonary fibrosis and lung tissue fibrosis and oxidative stress levels were detected. Results: In vivo, protodioscin decreased the levels of fibrosis markers and oxidative stress markers and activated Nrf2 in mice with pulmonary fibrosis, and these effects were inhibited by Nrf2 inhibitor. In vitro, protodioscin decreased the levels of myofibroblast markers and oxidative stress markers during myofibroblast transition and promoted Nrf2 downstream gene expression, with reversal of these effects after Nrf2, p62 and NBR1 genes were silenced or Nrf2 inhibitors were used, respectively. Protodioscin promoted the binding of NBR1 to p62 and Keap1, thereby reducing Keap1-Nrf2 binding. Conclusion: The NBR1-p62-Nrf2 axis is targeted by protodioscin to reduce oxidative stress and inhibit pulmonary fibrosis. [ABSTRACT FROM AUTHOR]

Polyethylene wax (PEW) serves as a versatile material modifier, and the newly acquired polarity functions after functionalization are of great interest. Furthermore, exploring methods to enhance product purity further is necessary. The rate of reaction between oxygen and PEW depends on both the diffusion rate of oxygen in the polymer and the thermodynamic properties of the reaction. To address these challenges and investigate changes in reaction mechanisms and properties, we employed supercritical carbon dioxide foaming to facilitate PEW oxidation while utilizing DFT theory to calculate oxidation reaction pathways and thermodynamic properties. The acid value of foamed PEW at 16 MPa and 115 °C increased by a factor of 2.7 compared to non-foamed PEW after 6 h of oxidation, indicating that foaming acted as an aid during this process. The generation of −OH, C = O, −CHO, and −COOH during the oxidation process was mutually confirmed through comprehensive analysis including FTIR, NMR spectroscopy, as well as other characterizations and calculations. Oxidized PEW (OPE) exhibited a maximum reduction in water contact angle (WCA) by 49°, a maximum decrease in crystallinity by 26.32%, and an increase in water vapour permeability by 61.8%. As a compatibilizer at a dosage level of 2.5 wt%, OPE demonstrated optimal compatibility improvement. Overall, foaming techniques effectively assisted the oxidation process, offering new possibilities for optimizing the structure and properties of PEW with potential applications within materials science. [ABSTRACT FROM AUTHOR]

Background: Staphylococcus aureus and its single or mixed biofilm infections seriously threaten global public health. Phage therapy, which uses active phage particles or phage-derived endolysins, has emerged as a promising alternative strategy to antibiotic treatment. However, high-efficient phage therapeutic regimens have yet to be established. Results: In this study, we used an enrichment procedure to isolate phages against methicillin-resistant S. aureus (MRSA) XN108. We characterized phage SYL, a new member of the Kayvirus genus, Herelleviridae family. The phage endolysin LysSYL was expressed. LysSYL demonstrated stability under various conditions and exhibited a broader range of efficacy against staphylococcal strains than its parent phage (100% vs. 41.7%). Moreover, dynamic live/dead bacterial observation demonstrated that LysSYL could completely lyse MRSA USA300 within 10 min. Scan and transmission electron microscopy revealed evident bacterial cell perforation and deformation. In addition, LysSYL displayed strong eradication activity against single- and mixed-species biofilms associated with S. aureus. It also had the ability to kill bacterial persisters, and proved highly effective in eliminating persistent S. aureus when combined with vancomycin. Furthermore, LysSYL protected BALB/c mice from lethal S. aureus infections. A single-dose treatment with 50 mg/kg of LysSYL resulted in a dramatic reduction in bacterial loads in the blood, liver, spleen, lungs, and kidneys of a peritonitis mouse model, which resulted in rescuing 100% of mice challenged with 108 colony forming units of S. aureus USA300. Conclusions: Overall, the data provided in this study highlight the strong therapeutic potential of endolysin LysSYL in combating staphylococcal infections, including mono- and mixed-species biofilms related to S. aureus. [ABSTRACT FROM AUTHOR]

The emergence of novel topological semimetal materials, accompanied by exotic non‐equilibrium properties, not only provides a fertile playground for a fundamental level of interest but also opens exciting opportunities for inventing new applications by making use of different light‐induced effects such as nonlinear optics, optoelectronics, especially for the highly pursued terahertz (THz) technology due to the gapless electronic structures. Exploring type‐II Weyl semimetal endowed with the richness of quantum wavefunction and peculiar band structure, underlie strong nonlinear coupling with THz waves. Here, the selective growth of type‐II Weyl semimetal NbIrTe4 by means of a self‐flux approach is reported, which hosts strongly tilted Weyl cones and exotic Fermi arcs. The oscillating THz field induced by the antenna is engineered in terms of planar metal‐topological semimetal‐metal structure, along with van der Waals stacking, which allows for self‐powered photodetection at room temperature. The results elucidate the superior performance of NbIrTe4‐graphene heterostructure‐based photodetectors with responsivity up to 264.6 V W−1 at 0.30 THz, fast response of 1 µs as well as low noise equivalent power ˂0.28 nW Hz−0.5 is achieved, already exhibiting high‐quality imaging at THz frequency. The results promise superb impacts in exploring topological Weyl semimetals for efficient low‐energy photon harvesting. [ABSTRACT FROM AUTHOR]

Digested wastewater contains pathogenic microorganisms and high ammonia concentrations, which can pose a potential risk to public health. Effective removal of pathogens and nitrogen is crucial for the post-treatment of digested wastewater. Partial nitrification-anammox is an energy-saving nitrogen removal process. Free nitrous acid (FNA), an intermediate product of partial nitrification, has the potential to inactivate microorganisms. However, the efficiency and mechanisms of FNA-related inactivation in pathogens during partial nitrification remains unclear. In this study, Enterococcus and Escherichia coli (E. coli) were selected to investigate the efficiency and mechanisms of FNA-related inactivation in partial nitrification process. The results revealed that 83% ± 13% and 59% ± 27% of E. coli and Enterococcus were removed, respectively, in partial nitrification process at FNA concentrations of 0.023–0.028 mg/L. When the concentration of FNA increased from 0 to 0.5 mg/L, the inactivation efficiencies of E. coli and Enterococcus increased from 0 to 99.9% and 89.9%, respectively. Enterococcus exhibited a higher resistance to FNA attack compared to E. coli. 3D-laser scanning microscopy (3D-LSM) and scanning electron microscopy (SEM) revealed that FNA exposure caused the surface collapse of E. coli and Enterococcus, as well as visible pore formation on the surface of E. coli cells. 4′,6-Diamidino-2-phenylindole dihydrochloride n-hydrate (DAPI)/propidium iodide (PI) and biomolecule leakage confirmed that inactivation of E. coli and Enterococcus occurred due to breakdown of cell walls and cell membranes. These findings indicate that partial nitrification process can be used for the removal of residual pathogenic microorganisms. [ABSTRACT FROM AUTHOR]

Background: Citrate anticoagulation is an important anticoagulation method in hemodialysis (HD) but cannot completely prevent the occurrence of coagulation in the extracorporeal circulation (ECC) circuit, and the clinical coagulation status can significantly affect the effect of citrate anticoagulation. In this study, the relationships between clinical coagulation status indicators and coagulation in the ECC circuit in HD patients receiving individualized citrate anticoagulant were studied to explore indicators that may predict coagulation in the ECC circuit. Methods: This study was a single‐center, retrospective clinical study, and clinical data and laboratory tests related to the coagulation status of HD patients receiving individualized regional citrate anticoagulation (RCA) were collected. The relationships between indicators commonly used in clinical practice to evaluate clinical coagulation status and coagulation in the ECC circuit were statistically analyzed to find indicators that can predict the occurrence of coagulation in the ECC circuit. Results: The individualized RCA had a good anticoagulation effect, and the actual citrate infusion rate in nearly 80% of the patients was within ±10% of the theoretical infusion rate. The combined diseases or conditions that affect the coagulation status in vivo may increase the incidence of coagulation in the ECC circuit. The clinical D‐dimer level is an independent risk factor that affects and can predict coagulation in the ECC circuit, with a cutoff value of 2.03 mg/L, sensitivity of 59%, and specificity of 78%. Conclusion: Individualized RCA can meet the needs of most HD treatments. Abnormal coagulation status in HD patients may increase the incidence of coagulation in the ECC circuit during individualized RCA for HD, and the D‐dimer level can predict the occurrence of coagulation in the ECC circuit during this treatment. [ABSTRACT FROM AUTHOR]

The thermoelectric generator (TEG) can convert heat to electricity and is widely used. To overcome the limitation for low efficiency of thermoelectric materials, optimizing the performance of TEG in given system is necessary. This study proposes a method to match individual TEG components to the system environment based on two boundary conditions—temperature and heat flux. With this method, TEG geometrical parameters can be determined to optimize the system performance by varying temperature as an independent variable. Using this method, the TEG in an undersea Radioisotope thermoelectric generator (u‐RTG) is optimized. The TEG system exhibits an output power of 14.10 W when powered by a 200 W heat source. The simulate result in the comprehensive system model of u‐RTG is 14.04 W, which has 0.45% deviation from the TEG optimization result. It is proved that the TEG optimized by this method matches the system, the optimization results are accurate. [ABSTRACT FROM AUTHOR]

The test raw materials for this study are from a tin tailings in Yunnan. The tin grade in the tailings is 0.35%, which is the main valuable element. Cassiterite accounts for 72.39% of the total tin mineral, the yield of -0.02 mm are as high as 67.11%, and the tin occupation is 68.00%. It is difficult to recover by traditional flotation and shaking table processes. In view of the high content of fine particles in the tailings, the centrifugal gravity separation method is chosen for the process. With the centrifugal gravity separation process, a crude tin concentrate with a tin grade of 1.27% and an operating recovery of 70% can be obtained by one stage of rough separation; The tin concentrate with a tin grade of 4.11% and a recovery of 54.10% can be obtained by adopting the process of one roughing and two cleaning. The combined process of centrifugal gravity separation (one rougher and one cleaner) + shaking table (secondary cleaner) can obtain a tin concentrate with a tin grade of 17.57% and a recovery of 17.25%. The results show that the full centrifugal gravity separation process can be used to obtain tin concentrate with high recovery; In order to obtain high-grade tin concentrate products, the combined process of centrifugation and shaking table can be used. Finally, the appropriate process can be determined according to the actual needs, which realizes the further development and utilization of cassiterite in the tailings. [ABSTRACT FROM AUTHOR]

As a core component of power conversion systems, insulated gate bipolar transistor (IGBT) modules continually suffer from severe thermal damage caused by temperature swings and shear stress, resulting in fatigue failure. Bond wires falling off is one of the failure modes of IGBT modules. Given that the number of fallen-off bond wires is a significant parameter to evaluate the health status of the IGBT modules, this paper proposes an online identification model to recognize the number of fallen-off bond wires during normal operation. Firstly, a database containing datum V c e , o n − T j − I C (collector–emitter on-state voltage V c e , o n , chip junction temperature T j , collector current I C ) planes with different fallen-off bond wires is built based on an offline aging test. Secondly, a Foster network model and a special circuit are designed to measure the junction temperature T j and the collector–emitter on-state voltage V c e , o n , respectively. Thirdly, the feature points of the IGBT module represented by V c e , o n , T j , and I C are given to the database to recognize the number of fallen-off bond wires according to the position of the feature points in the datum plane. The experimental results show that the proposed method can determine the fallen-off bond wires under the operation condition. [ABSTRACT FROM AUTHOR]

Structurally colored composite films, composed of orderly arranged colloids in polymeric matrix, are emerging flexible optical materials, but their production is bottlenecked by time-consuming procedures and limited material choices. Here, we present a mild approach to producing large-scale structurally colored composite films by shearing supramolecular composites composed of polymers and colloids with supramolecular interactions. Leveraging dynamic connection and dissociation of supramolecular interactions, shearing force stretches the polymer chains and drags colloids to migrate directionally within the polymeric matrix with reduced viscous resistance. We show that meter-scale structurally colored composite films with iridescence color can be produced within several minutes at room temperature. Significantly, the tunability and diversity of supramolecular interactions allow this shearing approach extendable to various commonly-used polymers. This study overcomes the traditional material limitations of manufacturing structurally colored composite films by shearing method and opens an avenue for mildly producing ordered composites with commonly-available materials via supramolecular strategies. Structurally coloured composite films are flexible optical materials with potential in a range of applications, but their production is impacted by long time-frames and limited materials. Here, the authors report a method for the production of large scale films by shearing supramolecular composites. [ABSTRACT FROM AUTHOR]

As global warming intensifies, the development of offshore wind farms is swiftly progressing, especially deep-water Floating Offshore Wind Turbines (FOWTs) capable of energy capture in deep-sea regions, which have emerged as a focal point of both academic and industrial interest. Although numerous researchers have conducted comprehensive and multifaceted studies on various components of wind turbines, less attention has been paid to the operational stage responses of FOWTs to wind, waves, and currents and the reliability of their structural components. This study primarily employs a theoretical analysis to establish mathematical models under a series of reasonable assumptions, examining the possibility of collisions between FOWT transport fleets and other vessels in the passage area during the towing process. Using the model, this paper takes the Wanning Floating Offshore Wind Farm (FOWF) project, which is scheduled to be deployed in the South China Sea, as its research object and calculates the probability of collisions between FOWTs and other vessels in three months from the pier near Wanning, Hainan, to a predetermined position 22 km away. The findings of the analysis indicate that the mathematical model developed in this study integrates the quantities and velocities of navigational vessels within the target maritime area as well as the speeds, routes, and schedules of the FOWT transport fleet. By employing statistical techniques and geometric calculations, the model can determine the frequency of collisions between various types of vessels and the FOWT transport fleet during the transportation period. This has substantial relevance for future risk assessments and disaster prevention and mitigation measures in the context of FOWT transportation. [ABSTRACT FROM AUTHOR]

The test raw materials for this study are from a tin tailings in Yunnan. The tin grade in the tailings is 0.35%, which is the main valuable element. Cassiterite accounts for 72.39% of the total tin mineral, the yield of -0.02 mm are as high as 67.11%, and the tin occupation is 68.00%. It is difficult to recover by traditional flotation and shaking table processes. In view of the high content of fine particles in the tailings, the centrifugal gravity separation method is chosen for the process. With the centrifugal gravity separation process, a crude tin concentrate with a tin grade of 1.27% and an operating recovery of 70% can be obtained by one stage of rough separation; The tin concentrate with a tin grade of 4.11% and a recovery of 54.10% can be obtained by adopting the process of one roughing and two cleaning. The combined process of centrifugal gravity separation (one rougher and one cleaner) + shaking table (secondary cleaner) can obtain a tin concentrate with a tin grade of 17.57% and a recovery of 17.25%. The results show that the full centrifugal gravity separation process can be used to obtain tin concentrate with high recovery; In order to obtain high-grade tin concentrate products, the combined process of centrifugation and shaking table can be used. Finally, the appropriate process can be determined according to the actual needs, which realizes the further development and utilization of cassiterite in the tailings. [ABSTRACT FROM AUTHOR]

Background: Qing-Zao-Jiu-Fei Decoction (QZJFD) is a famous herbal formula commonly prescribed for the treatment of lung-related diseases in the ancient and modern times. Trichosanthis Fructus (TF) and Fritillariae Thunbergii Bulbus (FTB) are widely used for treatment of cough and pulmonary disease. In order to identify a more effective formula for treatment of pulmonary fibrosis, we intend to add TF and FTB in QZJFD to form a modified QZJFD (MQZJFD). In this study, we aims to explore MQZJFD as an innovative therapeutic agent for pulmonary fibrosis using bleomycin (BLM)-treated rats and to unravel the underlying molecular mechanisms. Methods: BLM was given to SD rats by intra-tracheal administration of a single dose of BLM (5 mg/kg). QZJFD (3 g/kg) and MQZJFD (1, 2 and 4 g/kg) was given intragastrically daily to rats for 14 days (from day 15 to 28) after BLM administration for 14 consecutive days. Results: MQZJFD was found to contain 0.29% of amygdalin, 0.020% of lutin, 0.077% of glycyrrhizic acid and 0.047% of chlorogenic acid. BLM treatment could induce collagen deposition in the lung tissues of rats, indicating that the pulmonary fibrosis rat model had been successfully established. MQZJFD have better effects than the original QZJFD in reducing the pulmonary structure damage and collagen deposition of rat lung fibrosis induced by BLM. MQZJFD could reduce the hydroxyproline content in lung tissues of BLM-treated rats. The biomarkers of fibrosis such as matrix metalloproteinase 9 (MMP9), collagen I and α-smooth muscle actin (α-SMA) were remarkably reduced after treatment with MQZJFD. MQZJFD also have anti-oxidant stress effects by inhibiting the level of malondialdehyde (MDA), but enhancing the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the level of glutathione (GSH) in the lung tissues of BLM-treated rats. Moreover, the MQZJFD markedly suppressed the over expressions of p-p65/p65 and p-IκBα/IκBα, but upregulated the Nrf2. MQZJFD also suppressed the protein expressions of p-ERK1/2/ERK1/2, p-p38/p38 and p-JNK/JNK in the lung tissues of BLM-treated rats. Conclusions: MQZJFD could improve the pulmonary fibrosis induced by BLM in rats via inhibiting the fibrosis and oxidative stress via suppressing the activation of NF-κB/Nrf2 and MAPKs pathways. [ABSTRACT FROM AUTHOR]

BACKGROUND: Phenolic endocrine‐disrupting chemicals (EDCs) are widespread and easily ingested through the food chain. They pose a serious threat to human health. Magnetic solid‐phase extraction (MSPE) is an effective sample pre‐treatment technology to determine traces of phenolic EDCs. RESULTS: Magnetic covalent organic framework (COF) (Fe3O4@COF) nanospheres were prepared and characterized. The efficient and selective extraction of phenolic EDCs relies on a large specific surface and the inherent porosity of COFs and hydrogen bonding, π–π, and hydrophobic interactions between COF shells and phenolic EDCs. Under optimal conditions, the proposed magnetic solid‐phase extraction‐high‐performance liquid chromatography–ultra violet (MSPE‐HPLC‐UV) based on the metallic covalent organic framework method for phenolic EDCs shows good linearities (0.002–6 μg mL−1), with R2 of 0.995 or higher, and low limits of detection (6–1.200 ng mL−1). CONCLUSION: Magnetic covalent organic frameworks (Fe3O4@COFs) with good MSPE performance for phenolic EDCs were synthesized by the solvothermal method. The magnetic covalent organic framework‐based MSPE‐HPLC‐UV method was applied successfully to determine phenolic EDCs in beverage and water samples with satisfactory recoveries (90.200%–123%) and relative standard deviations (2.100%–12.100%). © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Staphylococcus aureus is one of the most prevalent bacteria found in acute wounds. S. aureus produces many virulence factors and extracellular enzymes that contribute to bacterial survival, dissemination, and pathogenicity. Lipase GehB is a glycerol ester hydrolase that hydrolyzes triglycerides to facilitate the evasion of S. aureus from host immune recognition. However, the role and mechanism of lipase GehB in skin acute wound healing after S. aureus infection remain unclear. In this study, we found that the gehB gene deletion mutant (USA300ΔgehB) stimulated significantly higher levels of pro-inflammatory cytokines in RAW264.7 and Toll-like receptor 2 (TLR2)-transfected HEK293 cells than the wild-type USA300 strain did. Recombinant GehB-His treated lipoprotein (Lpp) reduced stimulation of TLR2-dependent TNF-α production by RAW264.7 macrophages. GehB delayed the skin acute wound healing in BALB/c mice infected with S. aureus, while wound healing was similar in C57BL/6 TLR2−/− mice infected with either wild-type USA300 or USA300ΔgehB. In BALB/c mice, we also observed more bacterial survival, less leukocyte recruitment, lower IL-8 production, and adipocyte differentiation in USA300-infected skin acute wound tissues than those in USA300ΔgehB-challenged ones. Our data indicated that GehB inactivates lipoproteins to shield S. aureus from innate immune killing, resulting in delayed the healing of skin acute wounds infected with S. aureus. [ABSTRACT FROM AUTHOR]

Wear and wire fracture are the most common damage and failure modes of steel wire ropes (SWRs) under actual working conditions, which can induce the reduction of effective cross-sectional area and bearing capacity, and seriously affect the service lifespan of SWRs. Therefore, there is a risk of serious accidents and huge economic losses if the damage of the SWR in operation is not detected in time. Magnetic flaw signals of the SWRs can demonstrate its irreversible damage, and the damage evolution is manifested in complex and irregular fluctuations of the signals. In this article, the fatigue damage process of mine hoisting SWRs was simulated and damage signals were collected by non-destructive flaw detector. To evaluate fatigue damage of SWRs effectively, first, this study analyzed the spectrum features of damage signals based on the fast Fourier transform (FFT). In addition, it adopted a robust signal processing method, i.e., wavelet leaders-based multifractal (WLMF), to combine multifractal analysis with detection of bending fatigue damage of a SWR for the first time. The numerical analysis results show that as the number of bending fatigue cycles grows, the spectrum evolves into multiple peaks, and the amplitude corresponding to the dominant frequency expands. Moreover, the width of multifractal spectrum increases and the value range on the Y-axis of the singular spectrum expands synchronously with the number of fatigue cycles. For the damage parameters, an increase in Δh and a decrease in Δf indicate that the SWRs damage begins to accelerate and spread quickly. The multifractal spectrum parameters and scale function agree well with the geometric structure characteristics of damage signals. The reliability of the damage parameters is verified by counting the distribution and the number of broken wires under different fatigue cycles. Hence, it is a suitable method for fatigue damage detection and can be effectively applied to status monitoring and fault diagnosis of SWRs. [ABSTRACT FROM AUTHOR]

As a core component of photovoltaic power generation systems, insulated gate bipolar transistor (IGBT) modules continually suffer from severe temperature swings due to complex operation conditions and various environmental conditions, resulting in fatigue failure. The junction temperature prediction guarantees that the IGBT module operates within the safety threshold. The thermal equivalent circuit model is a common approach to predicting junction temperature. However, the model parameters are easily affected by the solder aging. An accurate temperature prediction by the model is impossible during service. This paper proposes an improved thermal equivalent circuit model that can remove the effect of solder aging. Firstly, the solder aging process is monitored in real-time based on the case temperatures. Secondly, the model parameters are corrected by the thermal impedance from chip to baseplate based on the linear thermal characteristic. The simulation and experimental results show that the proposed model can reduce the temperature prediction error by more than 90% under the same aging condition. The proposed method only depends on the case temperatures to correct the model parameters, which is more economical. In addition, the experimental and simulation analysis in this work can help students of power electronics courses have an in-depth knowledge of power devices' mechanical structure, heat dissipation principles, temperature distribution, junction temperature monitoring, and so on. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the safety and effectiveness of an individualized regional citrate anticoagulation (RCA) protocol for hemodialysis. Methods: In this single-center, retrospective study, blood coagulation in the extracorporeal circulation, adverse reactions, in vivo ionized calcium (iCa2+) concentrations, and the infusion dose of citrate during RCA in hemodialysis were observed in 98 patients from February 2021 to March 2022. Results: A total of 98 patients underwent RCA during hemodialysis 362 times, and blood coagulation occurred in the extracorporeal circulation 29 times. Among the 29 cases of coagulation, most of the patients exhibited hypercoagulability, and among approximately 80% of the treatments, the deviation between the actual infusion rate of citrate in the extracorporeal circulation and the theoretical value was ± 10%. After hemodialysis, pH values and bicarbonate ion (HCO3−) levels were clearly improved, and online conductivity monitoring (OCM) values and blood coagulation scores in the extracorporeal circulation were identical to those measured in similar studies. Conclusion: An individualized RCA protocol for hemodialysis is safe, effective, simple, and inexpensive and can meet the needs of individualized treatment; therefore, its application is worthy of promotion. [ABSTRACT FROM AUTHOR]

In addressing the challenges posed by the implications of climate change, understanding the phenological variations of woody plants has become a pivotal research topic. This research centers on the phenological shifts of woody plants and their connections with climatic factors in the southern and northern regions of the Nanling Mountains, which serve as the boundary between the north subtropical climate zone and the south subtropical climate zone in South China. The data were gathered through extensive manual observations conducted at four plant phenology observation stations (Ganxian, Foshan, Guilin, and Changsha) spanning different periods from 1963 to 2008. The study scrutinized four widely distributed woody plant species in the research area, specifically C. mollissima, P. fortunei, M. azedarach, and M. grandiflora. The analytical methods utilized were linear trend estimation and Pearson correlation coefficient analyses. The principal findings were as follows: (i) over the past several decades, the phenological stages of woody plants in the southern region consistently preceded those in the northern region with variations ranging from 2 to 38 days; (ii) an advancing trend of 0.1 to 2 days per decade was discerned in the phenological stages of all woody plants in the southern region; (iii) within the same geographic region, distinct species exhibited varying sensitivities to climatic factors, and M. azedarach demonstrated a particularly high sensitivity to climate fluctuations affecting phenological stages; and (iv) different climatic factors exerted distinct influences on individual plant species. Notably, temperature emerged as the primary driver of phenological changes, which was supported by a significant negative correlation between the phenological stages of the studied plants and spring temperatures. This study contributes to our understanding of the effects of climate change on plant phenology and offers valuable insights to guide ecological conservation and management strategies within the region. [ABSTRACT FROM AUTHOR]

Organizational climate is the ascribed psychological meaning and significance associated with the procedures, policies, and practices that are recognized and rewarded in the workplace and, hence, mediate the effects of environmental stimuli on individuals' responses. Safety climate is a specific organizational climate, i.e., organizational climate for safety. Previous research claimed that organizational climate provides a foundation for safety climate, but without elaboration on the foundational mechanisms. This paper attempts to fill this knowledge gap. As organizational climate is a multi-dimensional phenomenon, this paper chooses two dimensions: perceived organizational support (POS) and participative decision making (PaDM). Drawing on an interactive approach to forming climate perceptions, this paper introduces two interactive constructs—leader–member exchange (LMX) and team-member exchange (TMX)—and establishes a multiple mediation model depicting the foundational effect of organizational climate on safety climate. A random sample of 292 Hong Kong-based construction personnel is used to validate the model. The results show that both POS and PaDM are positively associated with perceived safety climate (β1 = 0.175, p < 0.01; β2 = 0.502, p < 0.005), both LMX and TMX fully mediate the effect of PaDM on safety climate (effect sizes are 0.146 and 0.076, respectively), and only LMX partially mediates the effect of POS on safety climate (effect size is 0.131). This study sheds light on the foundational effects of organizational climate on safety climate. POS can improve the quality of reciprocal exchange about safety matters between construction personnel and their supervisors and hence raise construction personnel's awareness of the priority of safety. PaDM can improve the quality of reciprocal exchange about safety matters vertically and horizontally and hence have construction personnel aware of the importance of safety. In practice, this paper suggests that project managers recognize and reward construction personnel's contributions in a timely manner, genuinely care about their well-being, and take their suggestions seriously in making decisions. In this way, the quality of both vertical and horizontal exchange about safety matters improves, and a sound and positive safety climate ensues. [ABSTRACT FROM AUTHOR]

Lignin is an important secondary metabolite that maintains the mechanical strength of horticultural plants and enhances their ability to respond to external environmental changes such as biotic and abiotic stresses. However, excessive accumulation of lignin can lead to lignification of horticultural products, reducing their taste quality and nutritional value. Therefore, the lignin content of horticultural products needs to be controlled at a reasonable level, and studying and regulating lignin metabolism is very meaningful work. This article focuses on the synthesis, accumulation, and regulation of lignin in horticultural crops in recent years, provides a systematic analysis of its molecular mechanism and application prospects, and sheds insights into the directions that need further research in the future. This article provides an important basis for the regulation of lignin accumulation and lignification in horticultural crops and proposes new ideas for improving the quality of horticultural crops. [ABSTRACT FROM AUTHOR]

Introduction: As a devastating neurological disease, spinal cord injury (SCI) results in severe tissue loss and neurological dysfunction. Pregnane X receptor (PXR) is a ligand‐activated nuclear receptor with a major regulatory role in xenobiotic and endobiotic metabolism and recently has been implicated in the central nervous system. In the present study, we aimed to investigate the role and mechanism of PXR in SCI. Methods: The clip‐compressive SCI model was performed in male wild‐type C57BL/6 (PXR+/+) and PXR‐knockout (PXR−/−) mice. The N2a H2O2‐induced injury model mimicked the pathological process of SCI in vitro. Pregnenolone 16α‐carbonitrile (PCN), a mouse‐specific PXR agonist, was used to activate PXR in vivo and in vitro. The siRNA was applied to knock down the PXR expression in vitro. Transcriptome sequencing analysis was performed to discover the relevant mechanism, and the NRF2 inhibitor ML385 was used to validate the involvement of PXR in influencing the NRF2/HO‐1 pathway in the SCI process. Results: The expression of PXR decreased after SCI and reached a minimum on the third day. In vivo, PXR knockout significantly improved the motor function of mice after SCI, meanwhile, inhibited apoptosis, inflammation, and oxidative stress induced by SCI. On the contrary, activation of PXR by PCN negatively influenced the recovery of SCI. Mechanistically, transcriptome sequencing analysis revealed that PXR activation downregulated the mRNA level of heme oxygenase‐1 (HO‐1) after SCI. We further verified that PXR deficiency activated the NRF2/HO‐1 pathway and PXR activation inhibited this pathway in vitro. Conclusion: PXR is involved in the recovery of motor function after SCI by regulating NRF2/HO‐1 pathway. [ABSTRACT FROM AUTHOR]

One of the most important causes of the failure of power electronic modules is thermal stress. Proper thermal management plays an important role in more reliable and cost-effective energy conversion. In this paper, we present an advanced active thermal control (ATC) strategy to reduce a power device's thermal stress amplitude during operation, with the aim of improving the reliability and lifetime of the conversion system. A state-space model based on a Foster-type thermal model is developed to achieve junction temperature estimation in real time. A feedback controller based on finite-time boundedness (FTB) is proposed to precisely regulate the temperature in order to reduce the thermal stress according to the temperature profile. The designed controller permits the precise control of the temperature and strongly reduces the thermal stress during fast transients in the power demand. Simulation and experimental results are provided to validate the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

The book "Translation, Adaptation and Digital Media" by John Milton and Silvia Cobelo explores the intersection between translation studies, adaptation studies, and the increasingly digital and globalized media environment. The book provides a comprehensive introduction to these fields and delves into various case studies and examples, including adaptations of Brazilian children's books, the influence of digital media on the translation and adaptation market, and adaptations of literary classics like Don Quixote. While the book has some limitations, such as a lack of diverse cultural examples, it is still considered a valuable contribution to the field and a useful resource for students and researchers. [Extracted from the article]

Shape memory photonic materials (SMPMs) are intelligent stimuli-responsive materials combining two different disciplines: shape memory polymers and photonic crystals. SMPMs can be programmed to one or more optically stable temporary configurations and recover to the initial configuration after being triggered by various external stimuli. In the shape memory cycle, the variation and fixation of structural colors are synchronized with the changes occurring in their micro/nanostructure of SMPMs. Because of the unique shape memory effect of micro/nanostructures, the variation of structural color can accurately convert the external stimuli into visualized optical signals in the shape memory cycles. Therefore, SMPMs have shown great potential in various applications, including actuators, visual sensors, anti-counterfeiting labels, and smart display units. This review summarizes shape memory mechanisms, micro/nanostructure design strategies, recent developments, and promising applications of SMPMs. Finally, the current challenges and future perspectives of SMPMs are discussed. This review aims to clarify the design principle for SMPMs and serve as a roadmap for exploring next-generation SMPMs. [ABSTRACT FROM AUTHOR]

Background: Previous studies have investigated the association between cardiometabolic risk factors and cardiovascular disease (CVD), but evidence of the attributable burden of individual and combined cardiometabolic risk factors for CVD and mortality is limited. We aimed to investigate and quantify the associations and population attributable fraction (PAF) of cardiometabolic risk factors on CVD and all-cause mortality, and calculate the loss of CVD-free years and years of life lost in relation to the presence of cardiometabolic risk factors. Methods: Twenty-two thousand five hundred ninety-six participants aged ≥ 35 without CVD at baseline were included between October 2012 and December 2015. The outcomes were the composite of fatal and nonfatal CVD events and all-cause mortality, which were followed up in 2018 and 2019 and ascertained by hospital records and death certificates. Cox regression was applied to evaluate the association of individual and combined cardiometabolic risk factors (including hypertension, diabetes and high low-density lipoprotein cholesterol (LDL-C)) with CVD risk and all-cause mortality. We also described the PAF for CVD and reductions in CVD-free years and life expectancy associated with different combination of cardiometabolic conditions. Results: During the 4.92 years of follow-up, we detected 991 CVD events and 1126 deaths. Hazard ratio were 1.59 (95% confidential interval (CI) 1.37–1.85), 1.82 (95%CI 1.49–2.24) and 2.97 (95%CI 1.85–4.75) for CVD and 1.38 (95%CI 1.20–1.58), 1.66 (95%CI 1.37–2.02) and 2.97 (95%CI 1.88–4.69) for all-cause mortality, respectively, in participants with one, two or three cardiometabolic risk factors compared with participants without diabetes, hypertension, and high LDL-C. 21.48% of CVD and 15.38% of all-cause mortality were attributable to the combined effect of diabetes and hypertension. Participants aged between 40 and 60 years old, with three cardiometabolic disorders, had approximately 4.3-year reductions life expectancy compared with participants without any abnormalities of cardiometabolic disorders. Conclusions: Cardiometabolic risk factors were associated with a multiplicative risk of CVD incidence and all-cause mortality, highlighting the importance of comprehensive management for hypertension, diabetes and dyslipidemia in the prevention of CVD. [ABSTRACT FROM AUTHOR]

Wood decomposition is a biogeochemical process fundamental to element cycling in forest ecosystems, which could alter the nutrient concentrations and enzyme activities of the underlying forest soils. Wood traits, which vary by tree species, can influence decomposition aboveground, but it is not well understood how wood decomposition associated with different tree types (i.e., angiosperm and gymnosperm species) influences underlying soil nutrient concentrations and enzyme activities. In this study, we evaluated how tree type (for four angiosperm vs. four gymnosperm species) affects underlying soil total carbon (C), nitrogen (N), and phosphorus (P) concentrations; microbial biomass C, N, and P concentrations; and C-, N-, and P-acquiring enzymes activities. We found that decomposing wood significantly increased soil total P, and microbial biomass C and P concentrations. However, the differences in the nutrient concentrations of soil and microbial biomass beneath decomposing wood were not different between angiosperm and gymnosperm species. Surprisingly, the activities of soil C-, N-, and P-acquiring enzymes beneath the decomposing wood differed significantly between angiosperm and gymnosperm species. The soils beneath decomposing angiosperm wood had higher P-acquiring enzyme activity, while the soils beneath gymnosperm wood had higher C- and N-acquiring enzyme activities. The soils beneath angiosperm and gymnosperm wood had a similar C-limitation for microbial metabolism, but the microbial metabolism in soils beneath angiosperm wood was more P-limited compared to soils beneath gymnosperm wood. In conclusion, our findings highlight that the tree types of decomposing wood may affect underlying soil enzyme activities and enzyme characteristics, improving our ability to accurately predict the role of wood decomposition on forest nutrient cycles. [ABSTRACT FROM AUTHOR]