68 results on '"He, Liyun"'
Search Results
2. Comparative analysis of atherosclerotic cardiovascular disease burden between ages 20–54 and over 55 years: insights from the Global Burden of Disease Study 2019.
- Author
-
Li, Ziyi, Yang, Yucheng, Wang, Xuechen, Yang, Na, He, Liyun, Wang, Jialu, Ping, Fan, Xu, Lingling, Zhang, Huabing, Li, Wei, and Li, Yuxiu
- Subjects
CORONARY disease ,MYOCARDIAL ischemia ,PERIPHERAL vascular diseases ,GLOBAL burden of disease ,AGE groups - Abstract
Background: To systematically analyze differences in atherosclerotic cardiovascular disease (ASCVD) burden between young and older adults. Methods: We estimated the prevalence, mortality, and disability-adjusted life years (DALYs) of ASCVD, including ischemic heart disease (IHD), ischemic stroke (IS), and peripheral artery disease (PAD), in individuals aged 20–54 and > 55 years from 1990–2019, utilizing data from the 2019 Global Burden of Disease Study. The annual percentage changes (EAPCs) for age-specific prevalence, mortality, or DALY rates were calculated to quantify the temporal trends of ASCVD burden. We also analyzed population attribution fractions (PAF) of premature ASCVD mortality and DALYs for different risk factors and compared the burden of extremely premature, premature, and non-premature ASCVD cases based on clinical classifications. Results: From 1990–2019, the global prevalence rates of IHD, IS, and PAD in the 20–54 years age group increased by 20.55% (from 694.74 to 837.49 per 100,000 population), 11.50% (from 439.48 to 490.03 per 100,000 population), and 7.38% (from 384.24 to 412.59 per 100,000 population), respectively. Conversely, the ASCVD prevalence in > 55years age group decreased. Adverse outcome burdens, including mortality and DALYs, varied among ASCVD subtypes. The decrease in the mortality/DALY burden of IHD and IS was lower in the 20–54 years group than in the > 55 years group. For PAD, DALYs among those aged 20–54 increased but decreased among those aged > 55 years. When grouped according to socio-demographic index (SDI) values, lower SDI regions exhibited a higher proportion of young ASCVD burden. The prevalence of young IHD, IS, and PAD in low SDI regions reached 20.70%, 40.05%, and 19.31% in 2019, respectively, compared with 12.14%, 16.32%, and 9.54%, respectively, in high SDI regions. Metabolic risks were the primary contributors to the ASCVD burden in both age groups. Increased susceptibility to ambient particulate matter pollution and inadequate control of high body-mass index and high fasting plasma glucose in young individuals may partially explain the differing temporal trends between young and older individuals. Conclusions: The ASCVD burden in young individuals may become a growing global health concern, especially in areas with lower socioeconomic development levels that require more effective primary prevention strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Impact of a dual glucose‐dependent insulinotropic peptide/glucagon‐like peptide‐1 receptor agonist tirzepatide on heart rate among patients with type 2 diabetes: A systematic review and pairwise and network meta‐analysis.
- Author
-
Yang, Yucheng, He, Liyun, Liu, Peng, Wang, Jialu, Yang, Na, Li, Ziyi, Ping, Fan, Xu, Lingling, Li, Wei, Zhang, Huabing, and Li, Yuxiu
- Subjects
TYPE 2 diabetes ,HEART beat ,GASTRIC inhibitory polypeptide ,RANDOMIZED controlled trials ,GLUCAGON-like peptide-1 agonists ,META-analysis - Abstract
Aims: To evaluate the impact of a dual glucose‐dependent insulinotropic peptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide (TZP), and its potential dose‐response effect, on heart rate. Methods: Articles were searched from PubMed, Web of Science, Embase, Cochrane Library, and clinical trials registries (ClinicalTrials.gov) databases. Randomized controlled trials (RCTs) comparing TZP at doses of 5, 10 and 15 mg in adults with type 2 diabetes were included. Six study arms were summarized from original research (TZP 5, 10 and 15 mg, GLP‐1 receptor agonists [GLP‐1RAs], insulin, placebo). The GLP‐1RA and non‐GLP‐1RA groups were combined to form a control group. Two reviewers independently extracted data and assessed the quality of each study. Mean differences (MDs) were calculated as effect estimates for continuous outcomes. Pairwise meta‐analyses and network meta‐analyses were conducted. The study protocol was prospectively registered (PROSPERO ID: CRD42023418551). Results: Eight articles were included in this systematic review and meta‐analysis. The mean baseline heart rate ranged from 65.2 to 75.7 beats per minute. Pairwise meta‐analysis showed that, compared with combined the control group, there were significantly greater increases in heart rates in the TZP group (MD 1.82, 95% confidence interval [CI] 0.75, 2.89). Similar significant rises were identified when comparing TZP with GLP‐1RAs and non‐GLP‐1RAs (GLP‐1 RAs: MD 2.29, 95% CI 1.00, 3.59; non‐GLP‐1RAs: MD 1.58, 95% CI 0.26, 2.91). TZP 5 mg was associated with smaller increases in heart rates compared to TZP 10 mg and TZP 15 mg (TZP 10 mg: MD −0.97, 95% CI −1.79, −0.14; TZP 15 mg: MD −2.57, 95% CI −3.79, −1.35). TZP 10 mg increased heart rate less than TZP 15 mg (MD −1.5, 95% CI −2.38, −0.82). Network meta‐analysis indicated that TZP 15 mg was associated with significant increases in heart rate compared with TZP 5 mg (MD 2.53, 95% CI 1.43, 3.62), TZP 10 mg (MD 1.44, 95% CI 0.35, 2.53), GLP‐1RAs (MD 3.46, 95% CI 1.67, 5.25), insulin (MD 2.86, 95% CI 1.32, 4.41) and placebo (MD 2.96, 95% CI 1.36, 4.57). Conclusions: Our study showed not only that there was a greater increase in heart rate in the TZP group than in the control, GLP‐1RA and non‐GLP‐1RA groups, but also that the 15‐mg dose of TZP had the strongest impact on increasing heart rates compared with the other five inventions, with a TZP dose‐response impact on heart rate. Further research on the effects of TZP treatment‐related increases in heart rate is required. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. The SHARE: SHam Acupuncture REporting guidelines and a checklist in clinical trials.
- Author
-
Ma, Peihong, Liu, Xiaoyu, Liu, Zhishun, Guo, Yi, Zhou, Kehua, Bian, Zhaoxiang, Sun, Chengyi, Liu, Tinglan, Xiong, Zhiyi, Xie, Yixuan, Lu, Ying, Lao, Lixing, He, Liyun, Liu, Baoyan, Liu, Cunzhi, and Yan, Shiyan
- Subjects
ACUPUNCTURE ,CLINICAL trials ,LITERATURE reviews ,COVID-19 testing ,SAMPLE size (Statistics) - Abstract
The article discusses the development of the SHARE (SHam Acupuncture REporting) guidelines and checklist for reporting sham acupuncture in clinical trials. Sham acupuncture is commonly used as a control in acupuncture research to evaluate the specific effects of acupuncture. However, the reporting quality of sham acupuncture in trials has been low, hindering the accurate understanding of its effects and leading to misunderstandings about the specific effects of acupuncture. The SHARE guidelines aim to improve the reporting quality of sham acupuncture by providing specific details about its implementation, including stimulation location, needle stimulation methods, and insertion technique. The guidelines also address contextual factors such as practitioner experience, practitioner-patient interaction, and patients' expectations of acupuncture. The SHARE checklist includes 19 subitems across 10 categories and can be used in any clinical trial involving sham acupuncture. The article recommends referencing both the SHARE and the STRICTA (STandards for Reporting Interventions in Controlled Trials of Acupuncture) checklist when conducting trials with sham acupuncture control. The development of the SHARE involved a literature review, Delphi surveys, consensus meetings, and pilot testing. The article acknowledges some limitations, such as the small sample size in the pilot test and the impact of COVID-19 on the consensus meetings. Overall, the SHARE guidelines and checklist aim to enhance the transparency, replication, and accuracy of sham acupuncture procedures in clinical trials. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
5. Effectiveness and safety of Angong Niuhuang pill (安宫牛黄丸) in treatment of acute stroke: a systematic review and Meta-analysis.
- Author
-
MENG Xiangran, CAO Xue, SUN Minglin, AI Yanke, HE Liyun, and LIU Jia
- Published
- 2023
- Full Text
- View/download PDF
6. Global, regional, and national time trends in cancer mortality attributable to high fasting plasma glucose: an age-period cohort analysis.
- Author
-
Xie, Jing, Liu, Zeye, Ren, Liqun, He, Liyun, Lu, Shan, Meng, Xiangzhi, Zhang, Xin, Su, Zhanhao, Jing, Shenqi, Shan, Tao, Wang, Junjie, Xia, Ruibing, Feng, Wei, Li, Yakun, Liu, Naifeng, and Liu, Yun
- Subjects
BLOOD sugar ,CANCER-related mortality ,COHORT analysis ,GLOBAL burden of disease ,AGE groups - Abstract
Background: High fasting plasma glucose (HFPG) is the fastest-growing risk factor for cancer deaths worldwide. We reported the cancer mortality attributable to HFPG at global, regional, and national levels over the past three decades and associations with age, period, and birth cohort. Methods: Data for this study were retrieved from the Global Burden of Disease Study 2019, and we used age-period-cohort modelling to estimate age, cohort and period effects, as well as net drift (overall annual percentage change) and local drift (annual percentage change in each age group). Results: Over the past 30 years, the global age-standardized mortality rate (ASMR) attributable to HFPG has increased by 27.8%. The ASMR in 2019 was highest in the male population in high sociodemographic index (SDI) areas (8.70; 95% CI, 2.23–18.04). The net drift for mortality was highest in the female population in low SDI areas (2.33; 95% CI, 2.12–2.55). Unfavourable period and cohort effects were found across all SDI quintiles. Cancer subtypes such as "trachea, bronchus, and lung cancers", "colon and rectal cancers", "breast cancer" and "pancreatic cancer" exhibited similar trends. Conclusions: The cancer mortality attributable to HFPG has surged during the past three decades. Unfavourable age-period-cohort effects on mortality were observed across all SDI quintiles, and the cancer mortality attributable to HFPG is expected to continue to increase rapidly in the future, particularly in lower SDI locations. This is a grim global public health issue that requires immediate attention. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Estimates and trends of the global burden of NASH-related liver cancer attributable to high fasting plasma glucose in 1990–2019: analysis of data from the 2019 Global Burden of Disease Study.
- Author
-
Li, Ziyi, Yang, Na, He, Liyun, Wang, Jialu, Ping, Fan, Li, Wei, Xu, Lingling, Zhang, Huabing, and Li, Yuxiu
- Subjects
GLUCOSE analysis ,GLOBAL burden of disease ,LIVER cancer ,BLOOD sugar ,DATA analysis - Abstract
Background: Experimental and epidemiological studies have indicated an association between diabetes exposure and an increased risk of liver cancer due to nonalcoholic steatohepatitis (NASH). However, to date, no systematic study has specifically investigated the burden of NASH-related liver cancer due to exposure to high fasting plasma glucose (HFPG) levels worldwide. Methods: The number and rate of deaths and disability-adjusted life years (DALYs) from HFPG-induced NASH-related liver cancer were estimated based on the results of the 2019 Global Burden of Disease Study. The estimated annual percentage changes (EAPCs) for age-standardized death or DALYs rates were calculated using a generalized linear model with a Gaussian distribution to quantify the temporal trends in the global burden of NASH-related liver cancer attributable to HFPG. The strength and direction of the association between the sociodemographic index (SDI) and death or DALY rate were measured using Spearman's rank-order correlation. Results: Globally, approximately 7.59% of all DALY and 8.76% of all mortalities of NASH-related liver cancer in 2019 were due to HFPG. The age-standardized death and DALY rates of NASH-related liver cancer attributable to HFPG increased from 1990 to 2019. The corresponding EAPCs were 0.69 (95% UI 0.48–0.89), and 0.30 (95% UI 0.05–0.56), respectively. This increasing pattern was most obvious in the high- and low-SDI regions. The age-standardized mortality and DALYs rate of NASH-related liver cancer attributable to HFPG varies considerably worldwide, with the middle SDI region having the highest death and DALY rates in 2019 (DALY 0.96 [95% UI 0.23–2.18]; death 0.05 [95% UI 0.01–0.11]). Conclusion: The burden of NASH-related liver cancer attributable to HFPG has increased over the past three decades, particularly in regions with high and low SDI. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Acupuncture Case Registry Study: Rationale, Implementations, and Achievements.
- Author
-
Zhao, Tianyi, Liu, Jia, Li, Yiming, Li, Hongjiao, Wang, Chao, Yang, Zhuoxin, Wang, Xin, Ai, Yanke, Qin, Yuning, Cao, Xue, Yue, Lihong, Ge, Zhishan, Wang, Shihua, Meng, Xiangran, Wang, Yanjun, and He, Liyun
- Subjects
REPORTING of diseases ,ETHICS ,ACUPUNCTURE ,PATIENT selection ,ACQUISITION of data ,PATIENT satisfaction ,TREATMENT effectiveness ,INTERPROFESSIONAL relations ,PATIENT safety - Abstract
The acupuncture case registry study is focusing on acupuncture therapy data from patient cases. The main objective is to collect real-world data and integrate clinically meaningful outcome evaluation indicators to uncover and evaluate real-world acupuncture efficacy and safety, explore factors affecting acupuncture efficacy, and provide real-world evidence to complement RCTs. Since the International Acupuncture Case Registry data collection system's establishment in 2017, 16 projects have been underway, including two acupuncture specialty therapies and 15 diseases. Data from 3404 patients included extensive information on the diagnosis and treatment of acupuncture and the evaluation of its efficacy. In order to serve as a guide for future studies, this article discusses the value of and rationale for establishing acupuncture case registry studies, how to distinguish them from patient registries, and crucial techniques for implementing registry studies in terms of applications, patient recruitment, costakeholder collaboration, data collection and management, study quality control, and ethics. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. Postmarketing Reevaluation of Chinese Traditional Therapy Kangbingdu Oral Liquid in the Treatment of the Common Cold.
- Author
-
Li, Hongjiao, Ai, Yanke, Zhao, Tianyi, Zhang, Di, Lv, Xiaoying, Jia, Shaoyan, Wen, Zehuai, Li, Guoxin, Wang, Hongyu, Gao, Feng, Li, Shaohong, Ge, Zhishan, Qin, Yuning, Wang, Zhenbiao, and He, Liyun
- Subjects
DRUG efficacy ,HERBAL medicine ,SCIENTIFIC observation ,CONFIDENCE intervals ,ORAL drug administration ,COMMUNITY health services ,MARKETING ,RANDOMIZED controlled trials ,DESCRIPTIVE statistics ,STATISTICAL sampling ,COMMON cold ,CHINESE medicine ,PATIENT safety ,LONGITUDINAL method ,DRUG administration ,DRUG dosage ,THERAPEUTICS - Abstract
Background. Observational studies from China suggest that Kangbingdu oral liquid (KBD) may be effective in treating the common cold. Objective. Reevaluation of efficacy and safety of Kangbingdu oral liquid after marketing and expanding population. Design. Prospective, Pragmatic randomized controlled trial (Chictr.org.cn registration number: chiCTR-TRC-12002399). Setting. Eleven hospitals from 3 provinces in China. Patients were recruited through 11 centers, including 7 teaching hospitals, 2 University health services, one military clinic, and one community hospital. Patients. 2647 persons aged 18 to 75 years with Common cold. Intervention. Patients were randomly allocated to 2 groups: the treatment group Kangbingdu oral liquid (composed of 9 Chinese herbal medicines and honey) and the placebo group were divided into a standard-dose group of 10 ml every time, a middle dose group of 20 ml every time, high dose group of 30 ml every time, 3 times daily. Interventions and control were given for 5 days. Measurements. The primary outcome is the mean amount of total scores measured by the 11-primary symptoms: to observe the change of main symptoms from severe to disappear and to calculate and compare the mean amount of total scores after the periods of observation. Secondary outcomes are the disappearance rate of each symptom and the median time of body temperature returned to normal. Results. On day 5, the Kangbingdu liquid group had significant reductions in the mean amount of total scores measured by the 11-primary symptoms (7.39 [95% CI 7.26 to 7.51] compared to the placebo group (6.43 [95%: CI 6.24 to 6.62]). The Kangbingdu liquid can improve the remission rate of accompanying symptoms on day 5 including aversion to wind, aversion to cold, fever, cough, stuffy, runny nose, sore throat, muscular aches, headache, fatigue, and sweat (P < 0.0001). Significant reductions in time of body temperature to return to normal in the Kangbingdu liquid group (P50, 48.33 [95% CI 46.00 to 52.50] compared with the control group (P50, 64.59 [95% CI 51.08 to 70.50] (P = 0.0022). 13 (0.7%) participants in the Kangbingdu liquid group and 1(0.2%) participants in the placebo group (P > 0.05) had treatment-related AEs, which mainly include diarrhea and dyspepsia in the Kangbingdu liquid group and constipation in the placebo group. Conclusion. The study's conclusion in this paper was based on the placebo, Kangbingdu oral liquid two groups which clinically diagnosed the common cold and flu. (1) Kangbingdu oral liquid can effectively improve the comprehensive clinical symptoms of common adult cold, also improved main symptoms, including sore throat, muscle aches, headache, and so on. (2) Kangbingdu oral liquid effectively shortens the time of body temperature to return to normal. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
10. Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials.
- Author
-
He, Liyun, Wang, Jialu, Ping, Fan, Yang, Na, Huang, Jingyue, Li, Yuxiu, Xu, Lingling, Li, Wei, and Zhang, Huabing
- Published
- 2022
- Full Text
- View/download PDF
11. Efficacy Analysis of the Reinforcing and Circulation-Promoting Protocol of Acupuncture and Moxibustion in Treatment of Twenty-Four Patients with Refractory Chronic Low Back Pain.
- Author
-
Zhou, Jincao, Wang, Jingjing, Chen, Zhongjie, Wu, Mozheng, Jiao, Yue, and He, liyun
- Subjects
CHRONIC pain treatment ,LUMBAR pain ,MOXIBUSTION ,CLINICAL trials ,PAIN measurement ,ACUPUNCTURE ,VISUAL analog scale ,MEDICAL protocols ,TREATMENT effectiveness ,BLOOD circulation ,DESCRIPTIVE statistics - Abstract
Objectives. The purpose of this study was to observe the clinical efficacy of the reinforcing and circulation-promoting protocol of acupuncture and moxibustion in treatment of refractory chronic low back pain, analyze therapeutic principles to obtain treatment efficacy, and develop new therapeutic principles to treat chronic low back pain. Methods. Twenty-four patients from the registry of patients suffering from refractory chronic low back pain were invited to our self-controlled case series, which was conducted in "real-world" settings. We implemented the reinforcing and circulation-promoting protocol of acupuncture and moxibustion to treat these patients and used the Visual Analogue Scale (VAS) and the Oswestry Disability Index (ODI) as the observation indices. Results. All 24 patients completed the treatment of acupuncture and moxibustion. The VAS of low back pain was 6.83 ± 2.18 before treatment and 2.13 ± 1.45 after treatment. The difference before and after treatment was significant (P < 0.001). The ODI was 28.21 ± 13.06 before treatment and 16.63 ± 7.20 after treatment. Their difference before and after treatment was significant (P < 0.001). Conclusion. The reinforcing and circulation-promoting protocol of acupuncture and moxibustion is effective in treating refractory chronic low back pain mainly because low back pain can be significantly relieved and motor function can be promoted. This trial was registered with AMCTR-OOO-17000045 (3 December 2016). [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
12. Evaluate the Correlation between the TIMI Frame Count, IMR, and CFR in Coronary Microvascular Disease.
- Author
-
Xu, Xinye, Zhou, Jinbao, Zhang, Yongzhen, Li, Qian, Guo, Lijun, Mao, Yanyang, and He, Liyun
- Subjects
CORONARY disease ,CORONARY angiography ,DRUG administration ,NITROGLYCERIN ,CORONARY vasospasm - Abstract
Objective: To evaluate the correlation between the TIMI frame count, IMR, and CFR in coronary microvascular disease (slow flow phenomenon).Methods: TFC and IMR were recorded in the nitroglycerin and ATP administration states, and the relationship between TFC, IMR, and CFR in specific states was analyzed.Results: A total of 41 patients with baseline TFC >25 frames on coronary angiography were enrolled, and nitroglycerin reduced TFC by 50% from baseline in 24 (58.54%) patients; 16 of the remaining 17 patients were able to achieve a 50% reduction in TFC by further intracoronary ATP injection. 10 patients were further tested for IMR, and the results showed significant correlations between baseline TFC and IMR (r = 0.775, P=0.008), TFC and IMR after nitroglycerin (r = 0.875, P=0.001), and the minimal TFC and IMR that could be obtained with nitroglycerin or ATP administration (r = 0.890, P=0.001). There was also a significant correlation between the proportional improvement in TFC and CFR before and after nitroglycerin injection (r = 0.685, P=0.029). In addition, we observed a lower IMR measured after nitroglycerin than after ATP in three patients, suggesting that CMD may be dominated by NO-sensitive vascular such as prearterioles and that an extensive analysis of the target site of CMD may be achieved by stepwise drug administration.Conclusion: Induction of TFC in different states by a stepwise drug approach may serve as a potential primary screening method for coronary microcirculatory dysfunction, thereby reducing the need for further IMR or CFR testing. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
13. The Fitting Optimization Path Analysis on Scale Missing Data: Based on the 507 Patients of Poststroke Depression Measured by SDS.
- Author
-
Lv, Xiaoying, Zhao, Ruonan, Su, Tongsheng, He, Liyun, Song, Rui, Wang, Qizhen, Yu, Xueyun, and Zhu, Yanbo
- Subjects
STATISTICS ,CONFIDENCE intervals ,STROKE patients ,MENTAL depression ,DESCRIPTIVE statistics ,PATH analysis (Statistics) ,DATA analysis ,DATA analysis software ,PREDICTION models ,ALGORITHMS - Abstract
Objective. To explore the optimal fitting path of missing data of the Scale to make the fitting data close to the real situation of patients' data. Methods. Based on the complete data set of the SDS of 507 patients with stroke, the data simulation sets of Missing Completely at Random (MCAR), Missing at Random (MAR), and Missing Not at Random (MNAR) were constructed by R software, respectively, with missing rates of 5%, 10%, 15%, 20%, 25%, 30%, 35%, and 40% under three missing mechanisms. Mean substitution (MS), random forest regression (RFR), and predictive mean matching (PMM) were used to fit the data. Root mean square error (RMSE), the width of 95% confidence intervals (95% CI), and Spearman correlation coefficient (SCC) were used to evaluate the fitting effect and determine the optimal fitting path. Results. when dealing with the problem of missing data in scales, the optimal fitting path is ① under the MCAR deletion mechanism, when the deletion proportion is less than 20%, the MS method is the most convenient; when the missing ratio is greater than 20%, RFR algorithm is the best fitting method. ② Under the Mar mechanism, when the deletion ratio is less than 35%, the MS method is the most convenient. When the deletion ratio is greater than 35%, RFR has a better correlation. ③ Under the mechanism of MNAR, RFR is the best data fitting method, especially when the missing proportion is greater than 30%. In reality, when the deletion ratio is small, the complete case deletion method is the most commonly used, but the RFR algorithm can greatly expand the application scope of samples and save the cost of clinical research when the deletion ratio is less than 30%. The best way to deal with data missing should be based on the missing mechanism and proportion of actual data, and choose the best method between the statistical analysis ability of the research team, the effectiveness of the method, and the understanding of readers. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities.
- Author
-
Zhang, Lunzhong, Han, Shu, Zhao, Manli, Zhang, Runshun, Zhang, Xuebin, Zhang, Jing, Liu, Xiaoqing, He, Yuyao, He, Zhao, Dong, Yunfang, Hou, Xiaoying, Mou, Zijun, He, Liyun, Zhou, Hong, Yang, Jie, Huang, Xingyan, Hu, Yanjie, Zhang, Yuefeng, Zhang, Lili, and Chen, Zhengguang
- Subjects
MEDICINE ,NOSOLOGY ,ISCHEMIC stroke ,INDIVIDUALIZED medicine ,DISEASE incidence ,FISHER exact test ,QUANTITATIVE research ,MICRORNA ,TREATMENT effectiveness ,DISEASE relapse ,MEDICAL protocols ,COMPARATIVE studies ,SEX distribution ,CELLULAR signal transduction ,DESCRIPTIVE statistics ,DECISION making in clinical medicine ,ELECTRONIC health records ,PATH analysis (Statistics) ,CHINESE medicine ,COMORBIDITY ,SYMPTOMS - Abstract
Background and Objectives. The development of network medicine provides new opportunities for disease research. Ischemic stroke has a high incidence, disability, and recurrence rate, and one of the reasons is that it is often accompanied by other complex diseases, including risk factors, complications, and comorbidities. Network medicine was used to try to analyze the characteristics of IS-related diseases and find out the differences in genetic pathways between Chinese herbs and Western drugs. Methods. Individualized treatment of traditional Chinese medicine (TCM) provides a theoretical basis for the study of the personalized classification of complex diseases. Utilizing the TCM clinical electronic medical records (EMRs) of 7170 in patients with IS, a patient similarity network (PSN) with shared symptoms was constructed. Next, patient subgroups were identified using community detection methods and enrichment analyses were performed. Finally, genetic data of symptoms, herbs, and drugs were used for pathway and GO analysis to explore the characteristics of pathways of subgroups and to compare the similarities and differences in genetic pathways of herbs and drugs from the perspective of molecular pathways of symptoms. Results. We identified 34 patient modules from the PSN, of which 7 modules include 98.48% of the whole cases. The 7 patient subgroups have their own characteristics of risk factors, complications, and comorbidities and the underlying genetic pathways of symptoms, drugs, and herbs. Each subgroup has the largest number of herb pathways. For specific symptom pathways, the number of herb pathways is more than that of drugs. Conclusion. The research of disease classification based on community detection of symptom-shared patient networks is practical; the common molecular pathway of symptoms and herbs reflects the rationality of TCM herbs on symptoms and the wide range of therapeutic targets. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
15. Efficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome : A Randomized Trial.
- Author
-
Sun, Yuanjie, Liu, Yan, Liu, Baoyan, Zhou, Kehua, Yue, Zenghui, Zhang, Wei, Fu, Wenbin, Yang, Jun, Li, Ning, He, Liyun, Zang, Zhiwei, Su, Tongsheng, Fang, Jianqiao, Ding, Yulong, Qin, Zongshi, Song, Hujie, Hu, Hui, Zhao, Hong, Mo, Qian, and Zhou, Jing
- Subjects
PELVIC pain ,PROSTATITIS ,CHRONIC pain ,ACUPUNCTURE ,CHINESE medicine ,MEDICAL sciences ,TWENTY twenties ,PELVIC pain treatment ,PROSTATITIS treatment ,RESEARCH ,PAIN measurement ,CHRONIC diseases ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,RANDOMIZED controlled trials ,STATISTICAL sampling ,DISEASE complications - Abstract
Background: Acupuncture has promising effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), but high-quality evidence is scarce.Objective: To assess the long-term efficacy of acupuncture for CP/CPPS.Design: Multicenter, randomized, sham-controlled trial. (ClinicalTrials.gov: NCT03213938).Setting: Ten tertiary hospitals in China.Participants: Men with moderate to severe CP/CPPS, regardless of prior exposure to acupuncture.Intervention: Twenty sessions of acupuncture or sham acupuncture over 8 weeks, with 24-week follow-up after treatment.Measurements: The primary outcome was the proportion of responders, defined as participants who achieved a clinically important reduction of at least 6 points from baseline on the National Institutes of Health Chronic Prostatitis Symptom Index at weeks 8 and 32. Ascertainment of sustained efficacy required the between-group difference to be statistically significant at both time points.Results: A total of 440 men (220 in each group) were recruited. At week 8, the proportions of responders were 60.6% (95% CI, 53.7% to 67.1%) in the acupuncture group and 36.8% (CI, 30.4% to 43.7%) in the sham acupuncture group (adjusted difference, 21.6 percentage points [CI, 12.8 to 30.4 percentage points]; adjusted odds ratio, 2.6 [CI, 1.8 to 4.0]; P < 0.001). At week 32, the proportions were 61.5% (CI, 54.5% to 68.1%) in the acupuncture group and 38.3% (CI, 31.7% to 45.4%) in the sham acupuncture group (adjusted difference, 21.1 percentage points [CI, 12.2 to 30.1 percentage points]; adjusted odds ratio, 2.6 [CI, 1.7 to 3.9]; P < 0.001). Twenty (9.1%) and 14 (6.4%) adverse events were reported in the acupuncture and sham acupuncture groups, respectively. No serious adverse events were reported.Limitation: Sham acupuncture might have had certain physiologic effects.Conclusion: Compared with sham therapy, 20 sessions of acupuncture over 8 weeks resulted in greater improvement in symptoms of moderate to severe CP/CPPS, with durable effects 24 weeks after treatment.Primary Funding Source: China Academy of Chinese Medical Sciences and the National Administration of Traditional Chinese Medicine. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
16. Mid-Arm Muscle and Subcutaneous Fat Associated with All-Cause Mortality Independent of BMI: A Prospective Cohort Study.
- Author
-
He, Liyun, Yang, Na, Wang, Jialu, Huang, Jingyue, Li, Wei, Xu, Lingling, Ping, Fan, Li, Yuxiu, and Zhang, Huabing
- Subjects
MORTALITY ,COHORT analysis ,PROPORTIONAL hazards models ,LONGITUDINAL method ,FAT ,RESEARCH ,MUSCLES ,ANTHROPOMETRY ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,RESEARCH funding ,BODY mass index ,ADIPOSE tissues - Abstract
Objective: This study aimed to systematically evaluate the association between triceps skinfold (TSF) thickness (which indicates subcutaneous fat) mid-arm muscle circumference (MAMC; which reflects muscle mass), mid-upper arm circumference (MUAC), and all-cause mortality.Methods: A total of 17,717 adults from the China Health and Nutrition Survey (1993-2015) were included. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. The joint effect of TSF thickness and MAMC was examined, and planned subgroup analyses were performed.Results: The highest quartiles of TSF thickness, MAMC, and MUAC were significantly associated with low all-cause mortality, independent of BMI (TSF thickness: HR = 0.704 [95% CI: 0.575-0.862]; MAMC: HR = 0.729 [95% CI: 0.607-0.876]; MUAC: HR = 0.713 [95% CI: 0.583-0.872]). A 1-SD increase showed comparable risk reductions for TSF thickness and MAMC (14.6% and 14.0%), with 16.1% risk reductions in MUAC. There were positive additive interactions between TSF thickness and MAMC. The inverse association existed in young, middle-aged, and elderly participants (P-heterogeneity > 0.05).Conclusions: Mid-arm muscle and subcutaneous fat were inversely associated with all-cause mortality, independent of BMI, beyond the elderly population. Mid-arm muscle and subcutaneous fat made comparable contributions to and had positive joint effects on all-cause mortality. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
17. Synchronous distance education vs traditional education for health science students: A systematic review and meta‐analysis.
- Author
-
He, Liyun, Yang, Na, Xu, Lingling, Ping, Fan, Li, Wei, Sun, Qi, Li, Yuxiu, Zhu, Huijuan, and Zhang, Huabing
- Subjects
EVALUATION of medical education ,ALTERNATIVE education evaluation ,CINAHL database ,CONFIDENCE intervals ,ERIC (Information retrieval system) ,INFORMATION storage & retrieval systems ,MEDICAL databases ,MEDICAL information storage & retrieval systems ,PSYCHOLOGY information storage & retrieval systems ,MEDLINE ,META-analysis ,ONLINE information services ,SATISFACTION ,STUDENTS ,STUDENT attitudes ,SYSTEMATIC reviews ,EDUCATIONAL outcomes ,DESCRIPTIVE statistics - Abstract
Context: Synchronous distance education (SDE) has been widely used for health science students in recent years. This study examined the effectiveness and acceptance of SDE compared with traditional education for health science students and explored the potential moderators that could impact the pooled results. Methods: A systematic review and meta‐analysis was conducted of randomised controlled trials (RCTs) from January 2000 to March 2020 searched on nine electronic databases, including Web of Science, PubMed, Cochrane Library, Scopus, EMBASE, CINAHL, ERIC, PsycINFO, and ProQuest Dissertations and Theses. The outcomes measured were knowledge, skills with objective assessments and overall satisfaction with subjective evaluations. The pooled results were calculated using random‐model effects, and moderators were explored through meta‐regression. Results: A total of seven RCTs with 594 participants were included. At the post‐test level, the pooled effect size of knowledge acquisitions (SMD 0.12, 95% CI −0.07‐0.32) showed insignificant difference between the SDE and traditional education groups (P =.207), with low heterogeneity (I2 = 17.6%). Subgroup analyses observed no factors that significantly impacted the pooled results of knowledge acquisition at the post‐test levels (P for interaction > 0.05). Knowledge gains from pretest to post‐test in SDE groups also did not differ significantly between groups (SMD 0.15, 95% CI −0.22‐0.53; P =.428). The pooled effect size of skills (SMD 0.02, 95% CI −0.24‐0.28; P =.735) was similarly insignificant. The pooled effect size of overall satisfaction (SMD 0.60, 95% CI 0.38‐0.83; P <.001) significantly favoured SDE over traditional education. Incorporating two‐group studies without randomisations did not significantly change the overall results of knowledge acquisition at the post‐test level (SMD −0.002, 95% CI −0.11‐0.10; P =.994), with moderate heterogeneity (I2 = 61.9%). Conclusions: Synchronous distance education was not significantly different from traditional education in effectiveness and had higher satisfaction ratings. Our findings might provide indications for adoptions of online remote education in health science education centres. Synchronous distance education appears to be neither better nor worse than traditional education but is often preferred. The findings should facilitate consideration now of how education might continue to evolve post‐pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
18. Long Sleep Duration is Associated with Increased High-Sensitivity C-Reactive Protein: A Nationwide Study on Chinese Population.
- Author
-
He, Liyun, Yang, Na, Ping, Fan, Xu, Lingling, Li, Wei, Li, Yuxiu, and Zhang, Huabing
- Subjects
CHINESE people ,C-reactive protein ,SLEEP ,BEHAVIOR therapy - Abstract
Purpose: High-sensitivity C-reactive protein (hs-CRP) has been shown as an important predictor of cardiovascular risk, and sleep duration is an important factor influencing health outcomes. However, the association between hs-CRP and sleep duration among Chinese adults remained unknown and controversial. We aimed to explore the associations between sleep duration and hs-CRP levels among Chinese adults, and the differences in sex and geographical regions. Methods: This cross-sectional study was based on nationally representative Chinese samples from the 2009 China Health and Nutrition Survey, which employed multistage, random cluster designs. Habitual sleep duration was self-reported with short and long sleep duration defined as ≤ 6h and ≥ 9h per day, respectively. Participants were divided into 4 groups based on the categories of self-reported sleep duration (≤ 6h, 7h, 8h, ≥ 9h per day), excluding hs-CRP levels ≥ 10 mg/L. Subset samples were stratified by sex and geographical regions. Results: A total of 8170 Chinese adults with a mean age of 50.0± 14.9 years and 4369 (53.5%) men were included. Participants sleeping eight hours had the lowest hs-CRP levels. Long sleep duration (≥ 9h) was significantly associated with elevated hs-CRP levels after adjusting for multiple covariates in full samples (β=0.0356; 95% CI: 0.0050– 0.0663; P=0.0228), but the associations of short sleep duration (≤ 6h) were limited to the unadjusted model. Long sleep duration was associated with elevated hs-CRP levels in women (β= 0.0512; 95% CI: 0.0097– 0.0927; P=0.0155) and in the northern region of China (β=0.0699; 95% CI: 0.0210– 0.1187; P=0.0051), but not in men or the southern region. Conclusion: Long but not short sleep duration was positively associated with elevated hs-CRP levels, independent from traditional risk factors among Chinese adults, and sex and geographical differences were observed. Our findings imply that modifications of long sleep duration might be added to behavioral therapy to reduce cardiovascular risk in Chinese adults. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
19. Subpopulation Differences in the Cardiovascular Efficacy of Long-Acting Glucagon-Like Peptide 1 Receptor Agonists in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.
- Author
-
He, Liyun, Yang, Na, Xu, Lingling, Ping, Fan, Li, Wei, Li, Yuxiu, and Zhang, Huabing
- Subjects
GLUCAGON-like peptide-1 agonists ,TYPE 2 diabetes ,GLUCAGON-like peptide 1 ,PEPTIDE receptors ,META-analysis ,CARDIOVASCULAR diseases - Abstract
Introduction: The cardiovascular efficacy of glucagon-like peptide 1 receptor agonists (GLP-1RAs) in type 2 diabetes mellitus (T2DM) are well documented; however, the differences in cardiovascular efficacy among subpopulations remain unknown. This systematic review and meta-analysis aimed to explore the differences in cardiovascular efficacy of long-acting GLP-1RAs among subpopulations of patients with T2DM and to assess the drug safety. Methods: Relevant studies up to March 31, 2020 were searched for in six electronic databases, namely PubMed, Cochrane Library, Embase, Clinical Trials, Science Direct, and Web of Science. The primary outcome was three-point major adverse cardiovascular events (including cardiovascular mortality, non-fatal myocardial infarction, and non-fatal stroke). Subpopulations were defined using ten selected influential factors, and the differences in cardiovascular efficacy in subpopulations stratified by different influential factors were accessed by synthesizing studies with random-effects models one by one. Results: A total of six cardiovascular outcome trials of long-acting GLP-1RAs, comprising 49,936 participants, were included. Among stratified subpopulations, no significant differences in the cardiovascular efficacy of long-acting GLP-1RAs were observed across the ten characteristics of subjects (all P for interaction > 0.05). Favorable trends were observed in the subpopulation with established cardiovascular disease (CVD) compared to that without (P = 0.171). With regards to safety, long-acting GLP-1RAs did not significantly increase the risk of retinopathy (OR 1.09; 95% CI 0.92–1.29; P = 0.316), but increase the risk of serious gastrointestinal events (OR 1.37; 95% CI 1.02–1.83; P = 0.037). Long-acting GLP-1RAs did not significantly increase the risk of serious adverse events (OR 0.92; 95% CI 0.85–1.00; P = 0.039). Conclusions: Our analysis suggested no subpopulation differences in the cardiovascular efficacy of long-acting GLP-1RAs among stratified subpopulations, and favorable trends were only observed in the subpopulation with established CVD. These findings may have implications for the management of long-acting GLP-1RAs across subpopulations of patients with T2DM. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
20. Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population.
- Author
-
Yang, Na, He, Liyun, Li, Yuxiu, Xu, Lingling, Ping, Fan, Li, Wei, and Zhang, Huabing
- Subjects
CHINESE people ,MEDIATION (Statistics) ,INSULIN resistance ,METABOLIC syndrome ,MAGNESIUM ,LOGISTIC regression analysis - Abstract
Purpose: High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). The aim of the cross-sectional analysis was to evaluate the association between dietary magnesium intake, IR, and MetS using data from China Health and Nutrition Survey. Methods: Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IR and the prevalence of MetS across the quartile categories of dietary magnesium intake. In addition, we used the macro PROCESS to perform the mediation analyses. Results: A total of 8120 participants were included in the final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals [CI] 0.376 to 0.502). The prevalence of the MetS was 38.6%, 28.9%, 22.5%, and 16.5% for increasing quartiles of dietary magnesium intake (p < 0.001). The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. The direct effect and indirect effect of dietary magnesium on MetS were found significant, and the calculated percentage of mediation by insulin resistance was 19.6%. Conclusion: Our study demonstrated a significant and independent negative relationship among weight-adjusted dietary magnesium intake, HOMA-IR, and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
21. Efficacy and safety of Xinfeng capsule in the treatment of osteoarthritis: a multicenter, randomized, double-blinded, controlled trial.
- Author
-
Liu Jian, Wang Yuan, Sun Yue, Huang Chuanbing, Chen Xi, Zhang Wandong, He Liyun, and Cheng-Chung Wei, James
- Published
- 2020
22. Effect of Individualized Dietary Intervention on Oxidative Stress in Patients with Type 2 Diabetes Complicated by Tuberculosis in Xinjiang, China.
- Author
-
He, Liyun, Zhang, Guoming, Wei, Meng, Zhao, Yanjun, Chen, Weixing, Peng, Qiaojun, and Meng, Guiyun
- Subjects
TYPE 2 diabetes ,OXIDATIVE stress ,TUBERCULOSIS - Abstract
Introduction: This study aimed to examine the effect of individual dietary intervention on nutrition and oxidative stress of patients with type 2 diabetes mellitus (T2DM) complicated by pulmonary tuberculosis (PTB) in Xinjiang. Methods: A total of 164 patients with T2DM and PTB from January 2018 to December 2018 in the Chest Hospital of Xinjiang Uyghur Autonomous Region were included. According to the random number table method, the patients were divided into an experimental group (n = 82) and control group (n = 82). The original treatments of PTB and T2DM were maintained. The control group was treated with a self-controlled diet, while the experimental group was treated with an individual quantitative dietary intervention. All patients included in our study were closely followed up for 3 months and the serum levels of variables related to nutrition, oxidative stress, and blood glucose were measured to compare each patient's nutritional and oxidative stress after the intervention. Proportions of patients with sputum testing positive for bacteria before and after the intervention were also recorded and compared between the two groups. Results: There were no significant differences between the two groups with regard to age, sex, labor intensity, marital status, course and treatment of diabetes, and proportion of patients with sputum positive for bacteria before the intervention (P > 0.05). There were statistically significant differences between the two groups in variables to related nutrition and oxidative stress, especially SOD which was increased by 13.2% in the experimental group and 2.5% in the control group after intervention (P < 0.05). The proportion of patients with sputum positive for bacteria in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion: A combination of individual quantitative dietary interventions can improve the nutritional status of patients with T2DM–PTB and adjust the oxidative stress. This method provides a theoretical basis for a reasonable diet in patients with T2DM–PTB. Trial Registration: ChiCTR900025477 (Retrospectively registered). [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
23. Dipeptidyl Peptidase 4 Inhibitors and Gallbladder or Biliary Diseases: Data From the U.S. Food and Drug Administration Adverse Event Reporting System.
- Author
-
He, Liyun, Wang, Jialu, Li, Ziyi, Li, Yuxiu, and Zhang, Huabing
- Abstract
The article reports that the dipeptidyl peptidase 4 inhibitors are used for patients with type 2 diabetes due to their favorable therapeutic profile and low risk of hypoglycemia. Topics include examines Glucagon-like peptide 1 receptor agonists were reported to be associated with increased risk of gallbladder or biliary diseases, which might be attributable to the effects of GLP-1.
- Published
- 2023
- Full Text
- View/download PDF
24. Efficacy of bevacizumab combined with erlotinib for advanced hepatocellular carcinoma: a single-arm meta-analysis based on prospective studies.
- Author
-
He, Liyun, Deng, Huan, Lei, Jun, Yi, Fengming, Li, Jine, Fan, Xiu De, Wei, Yiping, Xu, Jianjun, and Zhang, Wenxiong
- Subjects
HEPATOCELLULAR carcinoma ,BEVACIZUMAB ,LONGITUDINAL method ,META-analysis ,SCIENCE databases - Abstract
Background: The efficacy of bevacizumab combined with erlotinib (B + E) for the treatment of advanced hepatocellular carcinoma, especially for sorafenib-refractory patients, has been observed and evaluated in several trials. We conducted this single arm meta-analysis to generally assess the benefit and risk with B + E for advanced hepatocellular carcinoma.Methods: The PubMed, Cochrane Library, Embase, ScienceDirect, Web of Science and Scopus databases were searched for related studies. The main outcomes were objective response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS) and adverse effects (AEs).Results: Eight phase II clinical trials including 342 hepatocellular carcinoma patients were analyzed. The pooled ORR was 12.6% (95% CI: 6.3-19.0%), and the pooled DCR was 54.5% (95% CI: 48.9-66.8%). The 16-week PFS rate was 50.2% (95% CI: 38.2-62.2%). The 6- and 12-month OS rates were 77.8% (95% CI: 71.3-84.2%) and 44.9% (95% CI: 36.8-53.0%). The main grade 3-4 AEs were fatigue (11.9%), diarrhea (9.0%), hypertension (6.7%), acne (5.8%) and hemorrhage (5.3%). The only RCT showed that the B + E regimen had a consistent response and equable median OS but fewer toxicities (grade 3-4 AEs: 19% vs. 27%) than sorafenib. Subgroup analysis showed that as a second-line treatment, the B + E regimen had substantial value with a favorable PFS-16w (P = 0.012), OS-12 m (P = 0.048) and a favorable tendency of ORR (P = 0.089), but obvious toxicities in the second-line setting could not be neglected.Conclusion: Bevacizumab combined with erlotinib is effective for treating hepatocellular carcinoma patients, especially sorafenib-refractory patients. More well-designed and large-scale RCTs are warranted to prove our findings. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
25. The value of serum cystatin C in early evaluation of renal insufficiency in patients undergoing chemotherapy: a systematic review and meta-analysis.
- Author
-
He, Liyun, Li, Jine, Zhan, Jinfeng, Yi, Fengming, Fan, Xiude, Wei, Yiping, and Zhang, Wenxiong
- Subjects
CYSTATINS ,KIDNEY failure ,CANCER chemotherapy ,META-analysis ,CANCER patients - Abstract
Purpose: Several studies have shown that cystatin C levels can be used to detect decline in renal function in cancer patients receiving chemotherapy, and can serve as a supplement to creatinine level measurement for early detection of renal insufficiency. Nevertheless, use of the parameter remains controversial. This study aimed to assess the value of serum cystatin C levels in evaluation of early renal insufficiency due to chemotherapy.Methods: Studies were retrieved from PubMed, Ovid Embase, the Web of Science, the Cochrane Library, Ovid, and the CNKI databases up to May 15, 2018. Serum levels of cystatin C before and after chemotherapy were evaluated for its ability to assess renal function.Results: A total of 12 studies, including 1775 participants, met our inclusion and exclusion criteria. Pooled analysis revealed that the levels of serum cystatin C in cancer patients after chemotherapy were significantly higher than those of patients prior to treatment [standard mean difference (SMD) = 0.54, 95% CI 0.34-0.74, P = 0.0000]. Compared to creatinine, serum cystatin C increased significantly in the early phases of glomerular filtration rate (GFR) change before and after chemotherapy (GFR ≥ 90 ml/min/1.73 m2, P < 0.05 vs. P > 0.05, 5.83%; 60 < GFR < 90 ml/min/1.73 m2, P < 0.01 vs. P > 0.01, 38.83%) and increased more substantially in the later phases (GFR < 60 ml/min/1.73 m2, P < 0.01 vs. P < 0.01, 70.87% vs. 23.09%). However, creatinine decreased even in the early phases and did not increase in an obvious manner until the later phases (GFR < 60 ml/min/1.73 m2, P < 0.01, 23.09%). The GFR values were derived from measured methods.Conclusions: Cystatin C may be superior to creatinine for the detection of minor changes in GFR in early stages of renal insufficiency secondary to chemotherapy. More studies are needed to further verify this result. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
26. Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris.
- Author
-
Zhao, Yufeng, Yu, Xueyun, Cao, Xinyu, Luo, Lin, He, Liyun, Mao, Shusong, Ma, Li, Rong, Peijing, Zhao, Yuxue, Li, Guozheng, and Liu, Baoyan
- Abstract
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
27. Multistage analysis method for detection of effective herb prescription from clinical data.
- Author
-
Yang, Kuo, Zhang, Runshun, He, Liyun, Li, Yubing, Liu, Wenwen, Yu, Changhe, Zhang, Yanhong, Li, Xinlong, Liu, Yan, Xu, Weiming, Zhou, Xuezhong, and Liu, Baoyan
- Abstract
Determining effective traditional Chinese medicine (TCM) treatments for specific disease conditions or particular patient groups is a difficult issue that necessitates investigation because of the complicated personalized manifestations in real-world patients and the individualized combination therapies prescribed in clinical settings. In this study, a multistage analysis method that integrates propensity case matching, complex network analysis, and herb set enrichment analysis was proposed to identify effective herb prescriptions for particular diseases (e.g., insomnia). First, propensity case matching was applied to match clinical cases. Then, core network extraction and herb set enrichment were combined to detect core effective herb prescriptions. Effectiveness-based mutual information was used to detect strong herb-symptom relationships. This method was applied on a TCM clinical data set with 955 patients collected from well-designed observational studies. Results revealed that groups of herb prescriptions with higher effectiveness rates (76.9% vs. 42.8% for matched samples; 94.2% vs. 84.9% for all samples) compared with the original prescriptions were found. Particular patient groups with symptom manifestations were also identified to help investigate the indications of the effective herb prescriptions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
28. Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease.
- Author
-
Wang, Guisong, Mathew, Anna Vachaparampil, Yu, Haiyi, Li, Lei, He, Liyun, Gao, Wei, Liu, Xiaodan, Guo, Yanhong, Byun, Jaeman, Zhang, Jifeng, Chen, Y. Eugene, and Pennathur, Subramaniam
- Subjects
DENSITOMETERS ,MEASURING instruments ,OXIDATION-reduction reaction ,MASS spectrometry ,DIMERIC ions - Abstract
High density lipoprotein (HDL) cholesterol levels and cholesterol efflux capacity (CEC) are inversely correlated with coronary artery disease (CAD) risk. Myeloperoxidase (MPO) derived oxidants and HDL proteome changes are implicated in HDL dysfunction in subjects with CAD in the United States; however, the effect of MPO on HDL function and HDL proteome in ethnic Chinese population is unknown. We recruited four matched ethnic Chinese groups (20 patients each): subjects with 1) low HDL levels (HDL levels in men <40mg/dL and women <50mg/dL) and non-CAD (identified by coronary angiography or cardiac CT angiography); 2) low HDL and CAD; 3) high HDL (men >50mg/dL; women >60mg/dL) with no CAD; and 4) high HDL with CAD. Serum cytokines, serum MPO levels, serum CEC, MPO-oxidized HDL tyrosine moieties, and HDL proteome were assessed by mass spectrometry individually in the four groups. The cytokines, MPO levels, and HDL proteome profiles were not significantly different between the four groups. As expected, CEC was depressed in the entire CAD group but more specifically in the CAD low-HDL group. HDL of CAD subjects had significantly higher 3-nitrotyrosine than non-CAD subjects, but the MPO-specific 3-chlorotyrosine was unchanged; CEC in the CAD low-HDL group did not correlate with either HDL 3-chlorotyrosine or 3-nitrotyrosine levels. Neither 3-chlorotyrosine, which is MPO-specific, nor 3-nitrotyrosine generated from MPO or other reactive nitrogen species was associated with CEC. MPO mediated oxidative stress and HDL proteome composition changes are not the primary cause HDL dysfunction in Chinese subjects with CAD. These studies highlight ethnic differences in HDL dysfunction between United States and Chinese cohorts raising possibility of unique pathways of HDL dysfunction in this cohort. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
29. Evidence-Based Study to Compare Daodi Traditional Chinese Medicinal Material and Non-Daodi Traditional Chinese Medicinal Material.
- Author
-
Yang, Xingyue, Tian, Xin, Zhou, Yannan, Liu, Yali, Li, Xinlong, Lu, Tingting, Yu, Changhe, and He, Liyun
- Subjects
ANIMAL experimentation ,BIOLOGICAL products ,PHYSICAL & theoretical chemistry ,CHINESE medicine ,SOILS ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,DATA analysis software - Abstract
Background. Daodi medicinal material is widely used in Chinese herb medication. However, there is a lack of systematic methodology for identifying characteristics associated with good quality and reliable efficacy of Daodi med-material. Purpose. The purpose of this study is to provide some evidence to further substantiate the use of Daodi medicinal materials. Methods. Seven relevant databases were searched before July 2014. Two evaluators were responsible for screening and categorizing the results. The data was analyzed with Microsoft Excel 2007 and SPSS 21.0 statistical software. Results. Overall, 107 articles were systematically analyzed. Of these studies, 55.1% (59/107) focused on the methodology to assess Daodi med-material, and 38.3% (41/107) were interested in med-material ingredients, soil physical and chemical properties, and the geological background system (GBS). Only 6.5% (7/107) of studies were mainly conducted as clinical trials and animal experiments. Conclusion. Comparisons between Daodi and non-Daodi materials have been studied mainly in terms of the ingredients or composition of medical materials, soil physics and chemistry, and the GBS, and some identifying methodologies have been created to identify Daodi attributes. Until now, there is still no consensus of comparison criteria between Daodi and non-Daodi medicinal material. Only a few studies were conducted through animal experiments and clinical trials to determine Daodi superiority. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
30. Analysis of the Registration Information on Interventions of Acupuncture and Moxibustion Trials in the International Clinical Trials Registry Platform.
- Author
-
Liu, Yali, Chen, Wenjie, Tan, Yingxin, Yang, Xingyue, Liu, Jia, Lu, Tingting, Yan, Shiyan, He, Liyun, and Liu, Baoyan
- Subjects
ACUPUNCTURE ,HYPODERMIC needles ,MOXIBUSTION ,PAIN ,QUALITY assurance ,SYSTEMATIC reviews ,CLINICAL trial registries ,TREATMENT duration - Abstract
Purpose. To analyze and compare the clinical registration information about acupuncture and moxibustion for intervention characteristics. Methods. Clinical trials from the International Clinical Trials Registry Platform of the World Health Organization in acupuncture and moxibustion were comprehensively collected from 2013 to 2015; data were independently screened and extracted by two retrievers, and relevant data involving either basic descriptions or intervention characteristics were analyzed. Results. 425 acupuncture and moxibustion registered clinical trials were included; 88.00% (374/425) were designed as controlled studies, among which 38.59% (164/425) had sham acupuncture as the control group. The most common diseases were pain-related at approximately 19.29% (82/425) of trials. Reports on the intervention information in these acupuncture and moxibustion clinical studies were not sufficiently presented; these reports included the reporting of names of points (39.8%), the method of needle stimulation (32.5%), needle type (29.6%), needle retention time (34.1%), the number of treatment sessions (22.4%), and the frequency and duration of treatment sessions (38.1%). Conclusion. The registration information for the clinical trials of acupuncture and moxibustion was quite low according to this investigational study. Steps should be taken to improve the quality of acupuncture and moxibustion registration information. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
31. Factors related to acupuncture response in patients with chronic severe functional constipation: Secondary analysis of a randomized controlled trial.
- Author
-
Yang, Xingyue, Liu, Yan, Liu, Bing, He, Liyun, Liu, Zhishun, Yan, Yanshi, Liu, Jia, and Liu, Baoyan
- Subjects
ACUPUNCTURE ,CONSTIPATION ,SECONDARY analysis ,ELECTROACUPUNCTURE ,RANDOMIZED controlled trials - Abstract
Background: Acupuncture has been demonstrated to be effective and safe for chronic severe functional constipation (CSFC). However, which patients with CSFC will have a better response to acupuncture remains unclear. Objective: To explore factors related to acupuncture response in patients with CSFC. Methods: We performed a secondary analysis of a previous multicenter randomized controlled trial consisting of a 2-week run-in period, 8-week treatment, and 12-week follow-up without treatment in which patients with CSFC were randomly allocated to an electroacupuncture group or a sham electroacupuncture group. Responders were defined as participants with an increase of at least one complete spontaneous bowel movement (CSBM) in week 20 compared with the baseline period. The CSBM responder rate in both groups was described, and the baseline characteristics of participants potentially related to acupuncture response were mainly analyzed using logistic regression analysis with bootstrapping techniques. Results: A total of 1021 participants were analyzed in this study, of whom 516 (50.5%) were classified as responders. The CSBM responder rate in week 20 was significantly greater in the electroacupuncture group than in the sham electroacupuncture group (62.9% vs. 37.9%, respectively; P<0.001). Both age and comorbidity were negatively associated with clinical response: with every one-year increase in age, the likelihood of clinical response was reduced by 1.2% (OR 0.988, 95%CI 0.980 to 0.996; P = 0.005), and patients with comorbidities were approximately 42% less likely to respond to treatment (OR 0.581, 95%CI 0.248 to 0.914; P = 0.001). Conclusion: CSFC patients with increasing age and comorbidity may be less likely to respond to acupuncture. These findings contribute to guiding clinical practice in terms of pretreatment patient selection. Further research is needed to confirm the association. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
32. Preliminary construction of professionalism characteristics model of nursing undergraduate interns.
- Author
-
Ma Li, ReZiWanguli-rexiti, and He Liyun
- Published
- 2017
- Full Text
- View/download PDF
33. Research progress on professionalism and its influencing factors of nursing undergraduate trainees.
- Author
-
Ma Li, Peng Qiaojun, and He Liyun
- Published
- 2017
- Full Text
- View/download PDF
34. A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment.
- Author
-
Zhao, Yufeng, Liu, Bo, He, Liyun, Bai, Wenjing, Yu, Xueyun, Cao, Xinyu, Luo, Lin, Rong, Peijing, Zhao, Yuxue, Li, Guozheng, and Liu, Baoyan
- Abstract
Traditional Chinese patent medicines are widely used to treat stroke because it has good efficacy in the clinical environment. However, because of the lack of knowledge on traditional Chinese patent medicines, many Western physicians, who are accountable for the majority of clinical prescriptions for such medicine, are confused with the use of traditional Chinese patent medicines. Therefore, the aid-decision method is critical and necessary to help Western physicians rationally use traditional Chinese patent medicines. In this paper, Manifold Ranking is employed to develop the aid-decision model of traditional Chinese patent medicines for stroke treatment. First, 115 stroke patients from three hospitals are recruited in the cross-sectional survey. Simultaneously, traditional Chinese physicians determine the traditional Chinese patent medicines appropriate for each patient. Second, particular indicators are explored to characterize the population feature of traditional Chinese patent medicines for stroke treatment. Moreover, these particular indicators can be easily obtained byWestern physicians and are feasible for widespread clinical application in the future. Third, the aid-decision model of traditional Chinese patent medicines for stroke treatment is constructed based on Manifold Ranking. Experimental results reveal that traditional Chinese patent medicines can be differentiated. Moreover, the proposed model can obtain high accuracy of aid decision. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
35. Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial.
- Author
-
Zhang Guoliang, He Liyun, Tang Liuping, Yang Tong, Zou Xinying, Zhu Qingxiong, Yan Shiyan, Hou Yong, Huang Baoju, Zhao Jindong, Li Yan, and Huang Jihan
- Published
- 2017
- Full Text
- View/download PDF
36. Systematic review for geo-authentic Lonicerae Japonicae Flos.
- Author
-
Yang, Xingyue, Liu, Yali, Hou, Aijuan, Yang, Yang, Tian, Xin, and He, Liyun
- Abstract
In traditional Chinese medicine, Lonicerae Japonicae Flos is commonly used as anti-inflammatory, antiviral, and antipyretic herbal medicine, and geo-authentic herbs are believed to present the highest quality among all samples from different regions. To discuss the current situation and trend of geo-authentic Lonicerae Japonicae Flos, we searched Chinese Biomedicine Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text Database, Cochrane Central Register of Controlled Trials, Wanfang, and PubMed. We investigated all studies up to November 2015 pertaining to quality assessment, discrimination, pharmacological effects, planting or processing, or ecological system of geo-authentic Lonicerae Japonicae Flos. Sixty-five studies mainly discussing about chemical fingerprint, component analysis, planting and processing, discrimination between varieties, ecological system, pharmacological effects, and safety were systematically reviewed. By analyzing these studies, we found that the key points of geo-authentic Lonicerae Japonicae Flos research were quality and application. Further studies should focus on improving the quality by selecting the more superior of all varieties and evaluating clinical effectiveness. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
37. Application progress on dietary intervention in reducing oxidative stress state in patients with type 2 diabetes.
- Author
-
He Liyun and Peng Qiaojun
- Published
- 2016
- Full Text
- View/download PDF
38. Efficacy and safety of using a warming needle for persistent allergic rhinitis: study protocol for a randomized controlled trial.
- Author
-
Yuxiu Sun, Hong Zhao, Yongming Ye, Wenbin Nie, Wenjing Bai, Jia Liu, Sinuo Li, Fang Wang, Mingjuan Han, Liyun He, Sun, Yuxiu, Zhao, Hong, Ye, Yongming, Nie, Wenbin, Bai, Wenjing, Liu, Jia, Li, Sinuo, Wang, Fang, Han, Mingjuan, and He, Liyun
- Subjects
RANDOMIZED controlled trials ,PATIENT compliance ,ACUPUNCTURE ,ALLERGIC rhinitis ,HAY fever treatment ,DIAGNOSIS ,RHINITIS treatment ,RHINITIS ,ANTIHISTAMINES ,COMPARATIVE studies ,EXPERIMENTAL design ,HEAT ,HYPODERMIC needles ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH protocols ,QUALITY of life ,QUESTIONNAIRES ,RESEARCH ,TIME ,EVALUATION research ,TREATMENT effectiveness ,BLIND experiment ,LORATADINE ,PSYCHOLOGY ,EQUIPMENT & supplies ,THERAPEUTICS - Abstract
Background: Many previous studies have shown the potential therapeutic effect of acupuncture for allergic rhinitis. Most of these studies, however, were limited by the short duration of observations and lack of sham acupuncture as the control group. Our preliminary experiments showed that the use of a warm needling achieved a much more persistent effect in the treatment of allergic rhinitis (AR) compared with simple acupuncture therapy. Hence, we have designed a multicenter, randomized controlled trial (RCT) in which the first-line medication loratadine will be used as the control group, and the effect of warm needling therapy will be evaluated through long-term observation.Methods/design: The trial is designed as a multicenter, parallel-group, randomized, single-blinded (outcome assessors), non-inferiority trial. A total of 98 patients with persistent AR will be randomly assigned into two groups. Patients in the treatment group will be treated with warm needling at GV14 and acupuncture at EX-HN3, ST2, LI20, EX-HN8, GV23, LU7, LU5 and LI4 three times a week, for a total of 4 weeks. Patients in the control group will be treated with oral loratadine 10 mg/day for 4 weeks. The primary outcome will be the change in the Total Nasal Symptom Score (TNSS) from baseline to that at 6 months after treatment during the follow-up period. The secondary outcomes will include the Total Non-nasal Symptom Score and the Rhinoconjunctivitis Quality of Life Questionnaire, changes in the TNSS from baseline to that at 2 and 4 weeks during treatment, and 3 months after treatment during the follow-up period. Outcomes will be measured at 2 and 4 weeks, and 3 and 6 months after treatment. Any side effects of treatment will be observed and recorded.Discussion: We expect that the study results will provide evidence to determine the effects of warm needling compared with loratadine. Our final goal of the study is to evaluate the difference in the short-term and long-term effects between the two therapeutic methods, especially the long-term effect of warm needling.Trial Registration: ClinicalTrials.gov NCT02339714 . Registered on 14 January 2015. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
39. Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis: a multi-center parallel-group double-blind randomized controlled trial.
- Author
-
Liu Jian, Wang Yuan, Huang Chuanbing, Xu Jianhua, Li Zhijun, Xu Liang, He Liyun, Sun Yue, Wang Yali, Xu Shengqian, Zhao Ping, Mao Tongjun, Tan Bin, Zhu Fubing, Zhang Pingheng, and Fang Li
- Published
- 2015
- Full Text
- View/download PDF
40. Learning-Based Emulation of Sea Surface Wind Fields From Numerical Model Outputs and SAR Data.
- Author
-
He, Liyun, Fablet, Ronan, Chapron, Bertrand, and Tournadre, Jean
- Abstract
The availability of sea surface wind conditions with a high-resolution (HR) space-time sampling is a critical issue for a wide range of applications. Currently, no observation systems nor model forecasts provide relevant information with a high sampling rate in both space and time. Synthetic aperture radar (SAR) satellite systems deliver HR sea surface fields, with a spatial resolution below 0.01°, but they are also characterized by a large revisit time up 7 to 10 days for temperate zones. Meanwhile, operational model predictions typically involve a high temporal resolution (e.g., every 6 h), but also a low spatial resolution (0.5°). With a view to leveraging both data sources, we investigate statistical downscaling schemes. In this study, a new model based on a machine learning method, namely support vector regression (SVR), is built to reconstruct HR sea surface wind fields from low-resolution operational model forecasts. The considered case study off Norway demonstrates the relevance of the proposed SVR model. It outperforms state-of-the-art approaches [namely, linear, analog, and empirical orthogonal function (EOF) downscaling models] in terms of mean square error. It also realistically reproduces complex space-time variabilities of the observed SAR wind fields. We further discuss the SVR model as a generalization of the popular linear and analog models. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
- Full Text
- View/download PDF
41. TCM syndrome differentiation of AIDS using subspace clustering algorithm.
- Author
-
Zhao, Yufeng, Zhang, Xiang, Luo, Lin, He, Liyun, Liu, Baoyan, Xie, Qi, Li, Kun, Huo, Ruili, and Jing, Xianghong
- Published
- 2014
- Full Text
- View/download PDF
42. Statistical emulation of high-resolution SAR wind fields from low-resolution model predictions.
- Author
-
He, Liyun, Chapron, Bertrand, Tournadre, Jean, and Fablet, Ronan
- Published
- 2014
- Full Text
- View/download PDF
43. TCM syndrome classification of AIDS based on Manifold ranking.
- Author
-
Zhao, Yufeng, Luo, Lin, He, Liyun, Song, Guanli, Liu, Baoyan, Xie, Qi, Zhang, Xiaoping, Jian, Wang, and Jing, Xianghong
- Published
- 2014
- Full Text
- View/download PDF
44. Clinical Features for Mild Hand, Foot and Mouth Disease in China.
- Author
-
Liu, Baoyan, Luo, Lin, Yan, Shiyan, Wen, Tiancai, Bai, Wenjing, Li, Hongjiao, Zhang, Guoliang, Lu, Xiaoying, Liu, Yan, and He, Liyun
- Subjects
HAND diseases ,DIAGNOSIS of foot diseases ,ORAL disease diagnosis ,EPIDEMIOLOGY ,MORTALITY ,DIAGNOSIS - Abstract
Background: Mild hand, foot and mouth disease (HFMD) is at a critical stage owing to its ease of communicability and a higher risk of developing severe complications and death. Clinical diagnosis of mild HFMD was made by the presenting symptoms and signs (symptoms in brief) alone. We aim to evaluate the frequencies of symptoms in a retrospective case series study. Methods: We collected epidemiological, demographic, clinical, and laboratory data from outpatient and inpatient settings on the clinical data warehouse system. We principally described the frequencies of symptoms of mild HFMD. Correlations between symptoms with laboratory-confirmed cases were then analyzed. Results: The clinical data warehouse system included 3649 probable cases, between 2010 and 2012, of which 956 (26.20%) were laboratory confirmed. The peak incidence was identified in children 2 years of age. A total of 370 of the 956 laboratory confirmed cases (38.70%) were associated with enterovirus 71 (EV71). Logistic regression analysis adjusted for geographical variables, age, sex, month of onset, and time from onset to diagnosis showed that the clinical features constipation (P<0.0001; adjusted OR, 95%CI (2.99, 2.28–3.91)), and blisters (P<0.0001; adjusted OR, 95%CI (2.16, 1.82–2.56)) were positively correlated with the confirmed cases. Conclusions: This is the largest case series study, including all the guideline-mentioned symptoms of mild HFMD. Our findings suggest that blisters and constipation should be considered as potential warning signs while front-line clinicians manage surges of children diagnosed with mild HFMD during a pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
45. A Novel Classification Method for Syndrome Differentiation of Patients with AIDS.
- Author
-
Zhao, Yufeng, He, Liyun, Xie, Qi, Li, Guozheng, Liu, Baoyan, Wang, Jian, Zhang, Xiaoping, Zhang, Xiang, Luo, Lin, Li, Kun, and Jing, Xianghong
- Abstract
We consider the analysis of an AIDS dataset where each patient is characterized by a list of symptoms and is labeled with one or more TCM syndromes. The task is to build a classifier that maps symptoms to TCM syndromes. We use the minimum reference set-based multiple instance learning (MRS-MIL) method. The method identifies a list of representative symptoms for each syndrome and builds a Gaussian mixture model based on them. The models for all syndromes are then used for classification via Bayes rule. By relying on a subset of key symptoms for classification, MRS-MIL can produce reliable and high quality classification rules even on datasets with small sample size. On the AIDS dataset, it achieves average precision and recall 0.7736 and 0.7111, respectively. Those are superior to results achieved by alternative methods. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
46. A Discretization Algorithm That Keeps Positive Regions of All the Decision Classes.
- Author
-
Gabrys, Bogdan, Howlett, Robert J., Jain, Lakhmi C., Feng Honghai, Liu Baoyan, He LiYun, Yang Bingru, and Li Yueli
- Abstract
Most of the existing discretization methods such as k-interval discretization, equal width and equal frequency methods do not take the dependencies of decision attributes on condition attributes into account. In this paper, we propose a discretization algorithm that can keep the dependencies of the decision attribute on condition attributes, or keep the positive regions of the partition of the decision attribute. In the course of inducing classification rules from a data set, keeping these dependencies can achieve getting the set of the least condition attributes and the highest classification precision. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
47. Algorithms for Finding and Correcting Four Kinds of Data Mistakes in Information Table.
- Author
-
Gabrys, Bogdan, Howlett, Robert J., Jain, Lakhmi C., Feng Honghai, Xu Hao, Liu Baoyan, He LiYun, Yang Bingru, and Li Yueli
- Abstract
In a real world data set there are usually four kinds of mistaken values, the first one is the mistake in unit; the second one is the mistake of putting the radix points in wrong place, the third one is a scribal error, and the fourth one is a computational mistake. In this paper, we propose two algorithms for finding these four kinds of mistaken data. SARS and coronary heart disease data sets experimental results show that the two algorithms are available, that is, using the two algorithms we find some mistakes in the SARS and coronary heart disease data sets, and the results correspond to that found manually by medical experts. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
48. Using Rough Set to Induce More Abstract Rules from Rule Base.
- Author
-
Gabrys, Bogdan, Howlett, Robert J., Jain, Lakhmi C., Feng Honghai, Liu Baoyan, He LiYun, Yang Bingru, Li Yueli, and Zhao Shuo
- Abstract
In fault diagnosis and medical diagnosis fields, often there is more than one fault or disease that occur together. In order to obtain the factors that cause a single fault to change to multi-faults, the standard rough set based methods should be rebuilt. In this paper, we propose a decernibilty matrix based algorithm with which the cause of every single fault to change to multi-faults can be revealed. Additionally, we propose another rough set based algorithm to induce the common causes of all the single faults to change to their corresponding multi-faults, which is a process of knowledge discovery in rule base, i.e., not the usual database. Inducing more abstract rules in knowledge base is a very challenging problem that has not been resolved well. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
49. An Algorithm for Eliminating the Inconsistencies Caused During Discretization.
- Author
-
Gabrys, Bogdan, Howlett, Robert J., Jain, Lakhmi C., Feng Honghai, Liu Baoyan, He LiYun, Yang Bingru, Chen Yumei, and Zhao Shuo
- Abstract
Rough set based rule generation methods need discretization of the continuous values. However, most existing discretization methods cause inconsistencies. In this paper, we propose an algorithm that can eliminate the inconsistencies caused during the course of discretization. The algorithm can be integrated into the discaretization algorithms that cannot avoid causing inconsistencies to eliminate the inconsistencies. Three data experimental results show that the algorithm is available. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
50. Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditional Chinese medicine.
- Author
-
Zhou, Xuezhong, Li, Yubing, Peng, Yonghong, Hu, Jingqing, Zhang, Runshun, He, Liyun, Wang, Yinghui, Jiang, Lijie, Yan, Shiyan, Li, Peng, Xie, Qi, and Liu, Baoyan
- Abstract
Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands of years. However, the underlying mechanisms of TCM personalized medicine are not fully investigated so far and remained unknown. This paper discusses framework of TCM personalized medicine in classic literatures and in real-world clinical settings, and investigates the underlying mechanisms of TCM personalized medicine from the perspectives of network medicine. Based on 246 well-designed outpatient records on insomnia, by evaluating the personal biases of manifestation observation and preferences of herb prescriptions, we noted significant similarities between each herb prescriptions and symptom similarities between each encounters. To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links. This CPN is used to investigate the promiscuous boundary of syndromes and the co-occurrence of symptoms. The small-world topological characteristics are noted in the CPN with high clustering structures, which provide insight on the rationality of TCM personalized diagnosis and treatment. The investigation on this network would help us to gain understanding on the underlying mechanism of TCM personalized medicine and would propose a new perspective for the refinement of the TCM individualized clinical skills. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.