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Using Monte Carlo simulations, we investigate the phase behavior of hard rhombic platelets as a function of the thickness of the platelets, T. The phase diagram displays a columnar phase and a crystal phase in which the platelets are stacked in columns that are arranged in a two-dimensional lattice. We find that the shape of the platelets determines the symmetry of the two-dimensional lattice, i.e., rhombic platelets form an oblique columnar phase and a simple monoclinic crystal phase. For sufficiently thick platelets, i.e., for a thickness-to-length ratio T/L > 0.17, we find only an isotropic fluid, an oblique columnar phase, and a monoclinic crystal phase. Surprisingly, for an intermediate plate thickness, 0.083 < T/L < 0.17, we also find a region in between the isotropic (or nematic) phase and the columnar phase, where the smectic phase is stable. For sufficiently thin platelets, T/L < 0.13, the phase diagram displays a nematic phase. With the exception of the smectic phase, our results resemble the phase behavior of discotic particles. Our results may guide the synthesis and future experiments on rhombic nanoplatelets. [ABSTRACT FROM AUTHOR]

On chip waveguide optical amplifiers have been extensively studied over the last years, with a wide variety of materials tested and proposed for different applications. Among the most prominent solutions for on-chip amplification, erbium doped waveguide amplifiers (EDWAs) are able to offer attractive performance metrics that can exceed SOA-based amplification solutions in traditional single and multi-channel systems. In this letter, we experimentally demonstrate a record high $8\times 40$ Gbps non return to zero (NRZ) wavelength division multiplexing (WDM) data amplification through a 5.9 cm long on-chip amplifier consisting of an erbium-doped aluminum oxide spiral waveguide monolithically integrated on the Si3N4 platform. Experimental results show more than 12.7 dB amplification per channel for low saturation total input power of −2.75 dBm, and clear eye diagrams and bit-error rate values below the KR4-FEC limit of $2\times 10 ^{-5}$ for all eight channels without any digital signal processing (DSP) applied to the signal to the receiver or transmitter side. The high losses from the fiber to chip interfaces, however, prevented achieving device net gain. [ABSTRACT FROM AUTHOR]

We discovered a strongly lensed (μ ≳ 40) Ly α emission at z  = 6.629 (S/N ≃ 18) in the MUSE Deep Lensed Field (MDLF) targeting the Hubble Frontier Field (HFF) galaxy cluster MACS J0416. Dedicated lensing simulations imply that the Ly α emitting region necessarily crosses the caustic. The arc-like shape of the Ly α extends 3 arcsec on the observed plane and is the result of two merged multiple images, each one with a de-lensed Ly α luminosity L ≲ 2.8 × 1040 erg s−1 arising from a confined region (≲150 pc effective radius). A spatially unresolved Hubble Space Telescope (HST) counterpart is barely detected at S/N ≃ 2 after stacking the near-infrared bands, corresponding to an observed (intrinsic) magnitude m 1500 ≳ 30.8 (≳35.0). The inferred rest-frame Ly α equivalent width is EW0 > 1120 Å if the IGM transmission is T IGM < 0.5. The low luminosities and the extremely large Ly α EW0 match the case of a Population III (Pop III) star complex made of several dozens stars (∼104 M⊙) that irradiate an H  ii region crossing the caustic. While the Ly α and stellar continuum are among the faintest ever observed at this redshift, the continuum and the Ly α emissions could be affected by differential magnification, possibly biasing the EW0 estimate. The aforementioned tentative HST detection tends to favour a large EW0, making such a faint Pop III candidate a key target for the James Webb Space Telescope and Extremely Large Telescopes. [ABSTRACT FROM AUTHOR]

Due to remarkable advances in colloid synthesis techniques, systems of squares and cubes, once an academic abstraction for theorists and simulators, are nowadays an experimental reality. By means of a free minimization of the free-energy functional, we apply fundamental measure theory to analyze the phase behavior of parallel hard squares and hard cubes. We compare our results with those obtained by the traditional approach based on the Gaussian parameterization, finding small deviations and good overall agreement between the two methods. For hard squares, our predictions feature at intermediate packing fraction a smectic phase, which is however expected to be unstable due to thermal fluctuations. Due to this inconsistency, we cannot determine unambiguously the prediction of the theory for the expected fluid-to-crystal transition of parallel hard squares, but we deduce two alternative scenarios: (i) a second-order transition with a coexisting vacancy-rich crystal or (ii) a higher-density first-order transition with a coexisting crystal characterized by a lower vacancy concentration. In accordance with previous studies, a second-order transition with a high vacancy concentration is predicted for hard cubes. [ABSTRACT FROM AUTHOR]

In this paper we examine the phase behavior of the Weeks-Chandler-Andersen (WCA) potential with β[variant_greek_epsilon] = 40. Crystal nucleation in this model system was recently studied by Kawasaki and Tanaka [Proc. Natl. Acad. Sci. U.S.A. 107, 14036 (2010)], who argued that the computed nucleation rates agree well with experiment, a finding that contradicted earlier simulation results. Here we report an extensive numerical study of crystallization in the WCA model, using three totally different techniques (Brownian dynamics, umbrella sampling, and forward flux sampling). We find that all simulations yield essentially the same nucleation rates. However, these rates differ significantly from the values reported by Kawasaki and Tanaka and hence we argue that the huge discrepancy in nucleation rates between simulation and experiment persists. When we map the WCA model onto a hard-sphere system, we find good agreement between the present simulation results and those that had been obtained for hard spheres [L. Filion, M. Hermes, R. Ni, and M. Dijkstra, J. Chem. Phys. 133, 244115 (2010); S. Auer and D. Frenkel, Nature 409, 1020 (2001)]. [ABSTRACT FROM AUTHOR]

Over the last number of years several simulation methods have been introduced to study rare events such as nucleation. In this paper we examine the crystal nucleation rate of hard spheres using three such numerical techniques: molecular dynamics, forward flux sampling, and a Bennett-Chandler-type theory where the nucleation barrier is determined using umbrella sampling simulations. The resulting nucleation rates are compared with the experimental rates of Harland and van Megen [Phys. Rev. E 55, 3054 (1997)], Sinn et al. [Prog. Colloid Polym. Sci. 118, 266 (2001)], Schätzel and Ackerson [Phys. Rev. E 48, 3766 (1993)], and the predicted rates for monodisperse and 5% polydisperse hard spheres of Auer and Frenkel [Nature 409, 1020 (2001)]. When the rates are examined in units of the long-time diffusion coefficient, we find agreement between all the theoretically predicted nucleation rates, however, the experimental results display a markedly different behavior for low supersaturation. Additionally, we examined the precritical nuclei arising in the molecular dynamics, forward flux sampling, and umbrella sampling simulations. The structure of the nuclei appears independent of the simulation method, and in all cases, the nuclei contains on average significantly more face-centered-cubic ordered particles than hexagonal-close-packed ordered particles. [ABSTRACT FROM AUTHOR]

We study by computer simulations the stability of various crystal structures in a binary mixture of large and small spheres interacting either with a hard sphere or a screened-Coulomb potential. In the case of hard-core systems, we consider structures that have atomic prototypes CrB, γCuTi, αIrV, HgBr2, AuTe2, Ag2Se and the Laves phases (MgCu2, MgNi2, and MgZn2) as well as a structure with space group symmetry 74. By utilizing Monte Carlo simulations to calculate Gibbs free energies, we determine composition versus pressure and constant volume phase diagrams for diameter ratios of q=0.74, 0.76, 0.8, 0.82, 0.84, and 0.85 for the small and large spheres. For diameter ratios 0.76≤q≤0.84, we find the Laves phases to be stable with respect to the other crystal structures that we considered and the fluid mixture. By extrapolating to the thermodynamic limit, we show that the MgZn2 structure is the most stable one of the Laves structures. We also calculate phase diagrams for equally and oppositely charged spheres for size ratio of 0.73 taking into consideration the Laves phases and CsCl. In the case of equally charged spheres, we find a pocket of stable Laves phases, while in the case of oppositely charged spheres, Laves phases are found to be metastable with respect to the CsCl and fluid phases. [ABSTRACT FROM AUTHOR]

We investigate the decay of pair correlation functions in a homogeneous (bulk) binary mixture of hard spheres. At a given state point the asymptotic decay r→∞ of all three correlation functions is governed by a common exponential decay length and a common wavelength of oscillations. Provided the mixture is sufficiently asymmetric, size ratios q≤0.7, we find that the common wavelength reflects either the size of the small or that of the big spheres. By analyzing the (complex) poles of the partial structure factors we find a sharp structural crossover line in the phase diagram. On one side of this line the common wavelength is approximately the diameter of the smaller sized spheres whereas on the other side it is approximately the diameter of the bigger ones; the wavelength of the longest ranged oscillations changes discontinuously at the structural crossover line. Using density functional theory and Monte Carlo simulations we show that structural crossover also manifests itself in the intermediate range behavior of the pair correlation functions and we comment on the relevance of this observation for real (colloidal) mixtures. In highly asymmetric mixtures, q≤0.1, where there is metastable fluid-fluid transition, we find a Fisher-Widom line with two branches. This line separates a region of the phase diagram where the decay of pair correlations is oscillatory from one in which it is monotonic. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]

We report the identification of extended Lyα nebulae at z ≃ 3.3 in the Hubble Ultra Deep Field (HUDF, ≃40 kpc x 80 kpc) and behind the Hubble Frontier Field galaxy cluster MACSJ0416 (≃40 kpc), spatially associated with groups of star-forming galaxies. VLT/MUSE integral field spectroscopy reveals a complex structure with a spatially varying double-peaked Lyα emission. Overall, the spectral profiles of the two Lyα nebulae are remarkably similar, both showing a prominent blue emission, more intense and slightly broader than the red peak. From the first nebula, located in the HUDF, no X-ray emission has been detected, disfavouring the possible presence of active galactic nuclei. Spectroscopic redshifts have been derived for 11 galaxies within 2 arcsec from the nebula and spanning the redshift range 1.037 < z < 5.97. The second nebula, behind MACSJ0416, shows three aligned star-forming galaxies plausibly associated with the emitting gas. In both systems, the associated galaxies reveal possible intense rest-frame-optical nebular emissions lines [O iii] λλ4959, 5007+Hβ with equivalent widths as high as 1500 Å rest frame and star formation rates ranging from a few to tens of solar masses per year. A possible scenario is that of a group of young, star-forming galaxies emitting ionizing radiation that induces Lyα fluorescence, therefore revealing the kinematics of the surrounding gas. Also Lyα powered by star formation and/or cooling radiation may resemble the double-peaked spectral properties and the morphology observed here. If the intense blue emission is associated with inflowing gas, then we may be witnessing an early phase of galaxy or a proto-cluster (or group) formation. [ABSTRACT FROM AUTHOR]

We predict Lyman α (Lyα) luminosity functions (LFs) of Lyα-selected galaxies (Lyα emitters, or LAEs) at z = 3-6 using the phenomenological model. This model combines observed UV-LFs of Lyman-break galaxies (LBGs, or drop-out galaxies), with constraints on their distribution of Lyα line strengths as a function of UV-luminosity and redshift. Our analysis shows that while Lyα LFs of LAEs are generally not Schechter functions, these provide a good description over the luminosity range of log10(Lα/erg s-1) = 41-44. Motivated by this result, we predict Schechter function parameters at z = 3-6. Our analysis further shows that (i) the faint-end slope of the Lyα LF is steeper than that of the UV-LF of LBGs, (with a median αLyα < -2.0 at z ≳ 4), and (ii) a turnover in the Lyα LF of LAEs at Lyα luminosities 1040 ≲ Lα ≲ 1041 erg s-1 may signal a flattening of UV-LF of LBGs at -12 > MUV > -14. We discuss the implications of these results - which can be tested directly with upcoming surveys - for the Epoch of Reionization. [ABSTRACT FROM AUTHOR]

We quantify the directional dependence of the escape fraction of Lyman α (Lyα) and non-ionizing UV-continuum photons from a multiphase medium, and investigate whether there exist directional enhancements in the Lyα equivalent width (EW). Our multiphase medium consists of spherically symmetric distributions of cold, dusty clumps embedded within a hot dust-free medium. We focus on three models from the analysis presented by Laursen et al. We find that for a Lyα and UV-continuum point source, it is possible to find an EW boost $b(\theta ,\phi ) > 5 \bar{b}$ in a few per cent of sight lines, where $\bar{b}$ denotes the boost averaged over all photons. For spatially extended sources this directional dependence vanishes quickly when the size of the UV emitting region exceeds the mean distance between cold dusty clumps. Our analysis suggests that directional EW boosting can occur, and that this is mostly driven by reduced escape fractions of UV photons (which gives rise to UV-continuum ‘shadows’), and less due to an enhanced Lyα escape fraction (or beaming), in certain directions. [ABSTRACT FROM PUBLISHER]

Vascular endothelial growth factor-B (VEGF-B) has been implicated to play a significant role in coronary vessel growth and endothelial uptake and transport of fatty acids in heart and skeletal muscle. Additionally, recent studies have shown that Vegf-b deficiency protects from high-fat diet (HFD)-induced diabetes and insulin resistance. We compared the cardiac function and the effects of HFD on body composition and glucose metabolism in two available Vegf-b knockout (Vegf-b-/- strains) mouse strains side by side with their respective littermate controls. We found no differences in HFD-induced weight gain, glucose tolerance or insulin resistance between the Vegf-b-/- strains and their littermate control mice. Furthermore, there was no difference in basal cardiac function and cardiac expression of genes involved in glucose or fatty acid metabolism between the Vegf-b-/- strains and their littermate control mice. We conclude that VEGF-B is dispensable for normal cardiac function under unstressed conditions and for HFD-induced metabolic changes. [ABSTRACT FROM AUTHOR]

A control system using a low-drift power-feedback signal was implemented applying thermal waves, giving a sensor output independent of resistance drift and thermo-electric offset voltages on interface wires. Kelvin-contact sensing and power control is used on heater resistors, thereby inhibiting the influence of heater resistance drift. The thermal waves are detected with a sensing resistor using a lock-in amplifier and are mutually cancel�led by a thermal-wave balancing controller. Offset due to thermal gradient across the chip and resistor drift are eliminated by the lock-in amplifier and power controller, and therefore do not influence the sensor output signal. A microchannel thermal-wave balancing flow sensor with integrated Al resistors has successfully been fabricated. The thermal flow sensor is capable of measuring water flow rates with nl ⋅ min−1�precision, up to about 500 nl ⋅ min−1�full scale. Measurement results are in good agreement with a dynamic model of the flow sensor. Drift measurements show the sensor output signal to be compensated for resistance drift and thermal gradient across the chip. [ABSTRACT FROM AUTHOR]

We investigate the radiative transfer of Lyα photons through simplified anisotropic gas distributions, which represent physically motivated extensions of the popular shell models. Our study is motivated by the notion that (i) shell models do not always reproduce observed Lyα spectral line profiles; (ii) (typical) shell models do not allow for the escape of ionizing photons; and (iii) the observation and expectation that winds are more complex, anisotropic phenomena. We examine the influence of inclination on the Lyα spectra, relative fluxes and escape fractions. We find the flux to be enhanced/suppressed by factors up to a few depending on the parameter range of the models, corresponding to a boost in equivalent width of the same amplitude if we neglect dust. In general, lower mean optical depths tend to reduce the impact of anisotropies as is expected. We find a correlation between an observed peak in the - occasionally triple-peaked - spectrum at the systemic velocity and the existence of a low optical depth cavity along the line of sight. This can be of importance in the search for ionizing photons leaking from high- redshift galaxies since these photons will also be able to escape through the cavity. [ABSTRACT FROM AUTHOR]

We have used the SINFONI near-infrared integral field unit on the Very Large Telescope to resolve the optical emission line structure of one of the brightest (LLyα ≈ 1044 erg s-1) and nearest (z ≈ 2.38) of all Lyα blobs (LABs). The target, known in the literature as object "B1", lies at a redshift where the main optical emission lines are accessible in the observed near-infrared.We detect luminous [O III] λλ4959,5007 and Hα emission with a spatial extent of at least 32 × 40 kpc (4" × 5"). The dominant optical emission line component shows relatively broad lines (600-800 km s-1, FWHM) and line ratios consistent with active galactic nucleus (AGN) photoionization. The new evidence for AGN photoionization, combined with previously detected C IV and luminous, warm infrared emission, suggest that B1 is the site of a hidden quasar. This is confirmed by the fact that [O II] is relatively weak compared with [O III] (extinction-corrected [O III]/[O II] of about 3.8), which is indicative of a high, Seyfert-like ionization parameter. From the extinction-corrected [O III] luminosity we infer a bolometric AGN luminosity of ~3×1046 erg s-1, and further conclude that the obscured AGN may be Compton-thick given existing X-ray limits. The large line widths observed are consistent with clouds moving within the narrow-line region of a luminous QSO. The AGN scenario is capable of producing sufficient ionizing photons to power the Lyα, even in the presence of dust. By performing a census of similar objects in the literature, we find that virtually all luminous LABs harbor obscured quasars. Based on simple duty-cycle arguments, we conclude that AGNs are the main drivers of the Lyα in LABs rather than the gravitational heating and subsequent cooling suggested by cold stream models. We also conclude that the empirical relation between LABs and overdense environments at high redshift must be due to a more fundamental correlation between AGNs (or massive galaxies) and environment. [ABSTRACT FROM AUTHOR]

Acute myeloid leukemia (AML) is a highly heterogeneous disease, characterized by various cytogenetic and molecular abnormalities, many of which may express prognostic value. MicroRNAs (miRNAs) are a class of small regulatory RNAs. The prognostic value of miRNAs in AML is yet to be determined. Here, we set out to identify miRNAs that are consistent significant prognostic determinants, independent from other known prognostic factors. A discovery cohort (n=167) and validation cohort (n=409) of a heterogeneous AML population were used to reliably identify miRNAs with prognostic value. We report miR-212 as an independent prognostic factor, significantly associated with a prolonged overall survival (OS) and also event-free and relapse-free survival in a discovery cohort (hazard ratio (HR)s=0.77, P=0.015 for OS) that was subsequently confirmed in an independent validation cohort of 409 cases (HR=0.83, P=0.016). The prognostic significance and the prevalence of high miR-212 did not correlate with specific (cyto)genetic subtypes of AML. High miR-212 expression levels are associated with a gene expression profile that is significantly enriched for genes involved in the immune response. MiR-212 may improve the current prognostic risk stratification of mixed AML including normal karyotype AML and AML with cytogenetic and molecular abnormalities. [ABSTRACT FROM AUTHOR]

This article presents nano-slit electrospray emitters fabricated by a micro- to nanofluidic via technology. The main advantage of the technology is the ability to position freely suspended nanochannels anywhere on a microfluidic chip, where leak-tight delivery of fluid from a fluid reservoir can be established through long microchannels. The technology has proven to be useful in creating electrospray emitters coupled to freely suspended microchannels. It was observed that filling of nanochannels through via connections with integrated microchannels occurs not only due to bulk capillary action. These observations lead to a redesign of the electrospray chips. Repeatable electrospray IV-curves could be obtained from fabricated nano-slit electrospray emitters. Moreover, integration of on-chip microfluidic components is one of the possibilities of the fluidic via technology presented. [ABSTRACT FROM AUTHOR]

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Binary colloidal crystals offer great potential for tuning material properties for applications in, for example, photonics, semiconductors and spintronics, because they allow the positioning of particles with quite different characteristics on one lattice. For micrometer-sized colloids, it is believed that gravity and slow crystallization rates hinder the formation of high-quality binary crystals. Here, we present methods for growing binary colloidal crystals with a NaCI structure from relatively heavy, hard-spherelike, micrometer-sized silica particles by exploring the following external fields: electric, gravitational, and dielectrophoretic fields and a structured surface (colloidal epitaxy). Our simulations show that the free-energy difference between the NaCI and NiAs structures, which differ in their stacking of the hexagonal planes of the larger spheres, is very small (~O.OO2 ksfl. However, we demonstrate that the fcc stacking of the large spheres, which is crucial for obtaining the pure NaCI structure, can be favored by using a combination of the above-mentioned external fields. In this way, we have successfully fabricated large, 3D, oriented single crystals having a NaCI structure without stacking disorder. [ABSTRACT FROM AUTHOR]

A soft ultraviolet radiation field, eV, that permeates neutral intergalactic gas during the epoch of reionization (EoR) excites the 2p (directly) and 2s (indirectly) states of atomic hydrogen. Because the 2s state is metastable, the lifetime of atoms in this level is relatively long, which may cause the 2s state to be overpopulated relative to the 2p state. It has recently been proposed that for this reason, neutral intergalactic atomic hydrogen gas may be detected in absorption in its 3-cm fine-structure line against the cosmic microwave background out to very high redshifts. In particular, the optical depth in the fine-structure line through neutral intergalactic gas surrounding bright quasars during the EoR may reach . The resulting surface brightness temperature of tens of μK (in absorption) may be detectable with existing radio telescopes. Motivated by this exciting proposal, we perform a detailed analysis of the transfer of radiation, and reanalyse the detectability of the fine-structure line in neutral intergalactic gas surrounding high-redshift quasars. We find that proper radiative transfer modelling causes the fine-structure absorption signature to be reduced tremendously to . We therefore conclude that neutral intergalactic gas during the EoR cannot reveal its presence in the 3-cm fine-structure line to existing radio telescopes. [ABSTRACT FROM AUTHOR]

The morphological and spectroscopic properties of the giant (>60 kpc) Lyα nebulae associated with three radio galaxies at z∼ 2.5 (MRC 1558–003, 2025–218 and 0140–257) have been investigated using integral field spectroscopic data obtained with the Visible Multi-Object Spectrograph (VIMOS) on VLT. The morphologies are varied. The nebula of one source has a centrally peaked, rounded appearance. In the other two objects, it consists of two spatial components. The three nebulae are aligned with the radio axis within ≲30°. The total Lyα luminosities are in the range . The Lyα spectral profile shows strong variation through the nebulae, with full width at half-maximum (FWHM) values in the range ∼400–1500 km s−1 and velocity shifts . We present an infall model that can successfully explain the morphology, size, surface brightness distribution and the velocity field of the Lyα nebula associated with MRC 1558–003. It can also explain why Lyα is redshifted relative to other emission lines and the FWHM values of the non-resonant He ii line. This adds further support to our previous conclusion that the quiescent giant nebulae associated with this and other high-redshift powerful radio galaxies are in infall. A problem for this model is the difficulty to reproduce the large Lyα FWHM values, which might be the consequence of a different mechanism. We have discovered a giant (∼85 kpc) Lyα nebula associated with the radio galaxy MRC 0140–257 at z= 2.64. It shows strikingly relaxed kinematics (FWHM < 300 km s−1 and ), unique among high- z (≳2) radio galaxies. [ABSTRACT FROM AUTHOR]

The performance of an acoustic particle velocity sensor that is placed between two cylindrical objects has been analyzed both analytically and by means of finite volume simulations on fluid dynamics. The results are compared with acoustic experiments that show a large magnification of the output signal of the particle velocity sensor due to the mounting of the sensor between two cylinders. The influences of this construction consist of an attenuation of particle velocities at frequencies below a few hertz, whereas signals in the higher frequency range are amplified, up to approximately three times (10 dB) in a frequency range between 50 and 1000 Hz. The theoretical analysis is based on the derivation of the stream function for the situation of two long cylinders immersed in an oscillating incompressible viscous fluid, at low Reynolds numbers. The results lead to an improved insight into the effects of viscosity and fluid flow that play a role in acoustic measurements and open the way for further optimization of the sensitivity of the sensor. [ABSTRACT FROM AUTHOR]

Various manifestations of structural crossover in the properties of a binary mixture of hard-spheres are studied. For homogeneous mixtures that are sufficiently asymmetric, there is a crossover line in the phase diagram such that for thermodynamic states that lie on one side, the decay of the three bulk pair correlation functions is oscillatory with a common wavelength approximately equal to the diameter of the smaller spheres, and for states on the other side, the common wavelength is approximately the diameter of the bigger spheres. Using density functional theory it is shown that structural crossover manifests itself in the intermediate range decay of (i) the one-body density profiles of a hard-sphere mixture adsorbed at planar walls, (ii) the effective (depletion) potential between two big hard-spheres immersed in the same binary mixture, and (iii) the solvation force, or excess pressure, of the same mixture confined between two planar hard walls. The structural crossover line is determined exactly for a one-dimensional binary mixture of hard-rods and evidence is presented, based on density functional theory calculations and Monte-Carlo simulations, for structural crossover in homogeneous binary mixtures of hard-disks in two dimensions. By considering a multicomponent mixture of hard-spheres, with an appropriate bimodal distribution of diameters, it is argued that structural crossover should still occur in the presence of polydispersity and that these results could be relevant to colloidal mixtures where correlation functions can be measured using real-space techniques. [ABSTRACT FROM AUTHOR]

Local corticosteroids are widely used in the treatment of nasal polyps and chronic rhinosinusitis both before and after nasal surgery. Their efficacy after functional endoscopic sinus surgery (FESS) has not been fully established by placebo-controlled trials. This double-blind placebo-controlled randomized study was performed in order to investigate whether fluticasone propionate aqueous nasal spray (FPANS) reduces the recurrence rate of nasal polyps and chronic rhinosinusitis during the first year after FESS. The trial looked at 162 patients aged 18 years and older requiring FESS for chronic rhinosinusitis or nasal polyps. After FESS combined with peri-operative systemic corticosteroids, patients were randomized and given FPANS 400 μg b.i.d., FPANS 800 μg b.i.d. or placebo b.i.d. for the duration of 1 year. Patients were withdrawn from the trial (but still included in the study for statistical purposes) if there were recurrent or persistent diseases, defined as progressive regrowth of nasal polyps, recurrent signs and symptoms of chronic sinusitis combined with abnormalities on computed tomography scan and persistent complaints for at least 2 months after FESS. A significant reduction of symptoms was seen after FESS. After 1 year, 46 patients had been withdrawn from the trial because of recurrent diseases and 32 patients because of persistent symptoms. No differences in the number of patients withdrawn because of recurrent or persistent diseases were found between the patients treated with FPANS and patients treated with placebo. We were also unable to find a positive effect of FPANS compared with placebo in several subgroups such as patients with nasal polyps, high score at FESS or no previous sinus surgery. This placebo-controlled study does not show that treatment with FPANS up to 1 year after FESS had a positive effect compared with placebo. [ABSTRACT FROM AUTHOR]

The article presents in formation about the in virto technique to predict in vivo behavior of transfused, stored platelets. The storage of platelet concentrates (PCs) is restricted to 5 days because of the danger of bacterial contamination. Pathogen inactivation of PCs, or testing them for bacterial contamination, may be implemented in the future. It will then become possible to increase the storage time from 5 to 7 days. The information was obtained by sending questions to the experts in the field.

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Background The local production and release of a number of cytokines regulate allergic upper airway inflammation. Medication is usually used at the presentation of the first symptoms. There are, however, clues that it is advisable to start taking the corticosteroid before the grass pollen season begins. Methods This single allergen provocation study was conducted in autumn, out of the hay fever season. Nasal mucosa biopsies were taken twice before provocation (before and after 4 weeks of preventive treatment) and three times after allergen provocation (1 h, 24 h and 1 week). The preventive treatment used was fluticasone propionate aqueous nasal spray (FPANS) (n = 10) or a placebo (n = 9). Eosinophils and mRNA positive cells (in situ hybridization for IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IFNγ, RANTES and TNFα) were counted in the biopsies. Results Preventive treatment with FPANS out of season resulted in a decrease in eosinophils and mRNA positive cells for IL-5 and IL-6. After allergen provocation, levels of most of the measured cytokines (IL-3, IL-5, IL-6, IL-13, IFNγ, RANTES and TNFα) and eosinophils were reduced using corticosteroids. The numbers of cells (eosinophils, IL-3, IL-6 and IL-8) correlated with nasal symptoms. Significant correlations in the early and late allergic phase were found between eosinophils and cytokines (IL-3, IL-10 and IL-13). Conclusion These results indicate that preventive treatment with FPANS prior to contact with grass pollen is effective in reducing the increase of cytokine mRNA positive cells in reaction to grass pollen contact. [ABSTRACT FROM AUTHOR]