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Head‐direction (HD) cells are a fundamental component in the hippocampal‐entorhinal circuit for spatial navigation and help maintain an internal sense of direction to anchor the orientation in space. A classical HD cell robustly increases its firing rate when the head is oriented toward a specific direction, with each cell tuned to only one direction. Although unidirectional HD cells are reported broadly across multiple brain regions, computation modelling has predicted the existence of multiple equilibrium states of HD network, which has yet to be proven. In this study, a novel HD variant of bipolar HD cells in the medial entorhinal cortex (MEC) are identified that exhibit stable double‐peaked directional tuning properties. The bipolar patterns remain stable in the darkness and across environments of distinct geometric shapes. Moreover, bipolar HD cells co‐rotate coherently with unipolar HD cells to anchor the external visual cue. The discovery reveals a new spatial cell type of bipolar HD cells, whose unique activity patterns may comprise a potential building block for a sophisticated local neural circuit configuration for the internal representation of direction. These findings may contribute to the understanding of how the brain processes spatial information by shedding light on the role of bipolar HD cells in this process. [ABSTRACT FROM AUTHOR]

Background: Osteoradionecrosis (ORN) of the upper cervical spine is a rare but severe complication of head and neck cancer radiotherapy. To raise awareness of this condition, we describe a patient with a history of nasopharyngeal carcinoma who developed ORN of the upper cervical spine and review the published literature reporting surgical management. Case presentation: A 59-year-old female patient with persistent neck pain for one month and limited range of neck motion who had undergone radiotherapy for nasopharyngeal carcinoma with a total dose of 69.96 Gy 15 years ago presented to our hospital. The patient underwent endoscopic transnasal and transoral resection of the odontoid process and C1 anterior arch, combined with occipitocervical fusion. To better understand surgical management of ORN of the upper cervical spine, the literature published in the PubMed, Ovid MEDLINE, and Embase databases was reviewed. Our patient experienced alleviation of cervical pain and did not exhibit any postoperative complications. Since 2005, 11 cases of surgical management of ORN of the upper cervical spine (including the present case) have been published. Basilar invagination and/or atlantoaxial subluxation were observed in 4 /11 cases. Endoscopic procedures were performed in 4/11 cases, and occipitocervical fusion was performed in 8 /11 cases. Conclusion: Endoscopic transnasal and transoral resection of the odontoid process and C1 anterior arch is a safe and effective treatment option for ORN of the upper cervical spine. Occipitocervical fusion is useful in patients with basilar invagination and atlantoaxial subluxation. [ABSTRACT FROM AUTHOR]

Platinum‐based supported intermetallic alloys (IMAs) demonstrate exceptional performance in catalytic propane dehydrogenation (PDH) primarily because of their remarkable resistance to coke formation. However, these IMAs still encounter a significant hurdle in the form of catalyst deactivation. Understanding the complex deactivation mechanism of supported IMAs, which goes beyond conventional coke deposition, requires meticulous microscopic structural elucidation. In this study, we unravel a nonclassical deactivation mechanism over a PtZn/γ‐Al2O3 PDH catalyst, dictated by the PtZn to Pt3Zn nanophase transformation accompanied with dezincification. The physical origin lies in the metal support interaction (MSI) that enables strong chemical bonding between hydroxyl groups on the support and Zn sites on the PtZn phase to selectively remove Zn species followed by the reconstruction towards Pt3Zn phase. Building on these insights, we have devised a solution to circumvent the deactivation by passivating the MSI through surface modification of γ‐Al2O3 support. By exchanging protons of hydroxyl groups with potassium ions (K) on the γ‐Al2O3 support, such a strategy significantly minimizes the dezincification of PtZn IMA via diminished metal‐support bonding, which dramatically reduces the deactivation rate from 0.2044 to 0.0587 h−1. These findings decode the nonclassical PDH deactivation mechanism over supported IMA catalysts and elaborate a new logic for the design of high‐performance IMA based PDH catalysts with long‐term stability. [ABSTRACT FROM AUTHOR]

Platinum‐based supported intermetallic alloys (IMAs) demonstrate exceptional performance in catalytic propane dehydrogenation (PDH) primarily because of their remarkable resistance to coke formation. However, these IMAs still encounter a significant hurdle in the form of catalyst deactivation. Understanding the complex deactivation mechanism of supported IMAs, which goes beyond conventional coke deposition, requires meticulous microscopic structural elucidation. In this study, we unravel a nonclassical deactivation mechanism over a PtZn/γ‐Al2O3 PDH catalyst, dictated by the PtZn to Pt3Zn nanophase transformation accompanied with dezincification. The physical origin lies in the metal support interaction (MSI) that enables strong chemical bonding between hydroxyl groups on the support and Zn sites on the PtZn phase to selectively remove Zn species followed by the reconstruction towards Pt3Zn phase. Building on these insights, we have devised a solution to circumvent the deactivation by passivating the MSI through surface modification of γ‐Al2O3 support. By exchanging protons of hydroxyl groups with potassium ions (K) on the γ‐Al2O3 support, such a strategy significantly minimizes the dezincification of PtZn IMA via diminished metal‐support bonding, which dramatically reduces the deactivation rate from 0.2044 to 0.0587 h−1. These findings decode the nonclassical PDH deactivation mechanism over supported IMA catalysts and elaborate a new logic for the design of high‐performance IMA based PDH catalysts with long‐term stability. [ABSTRACT FROM AUTHOR]

The characteristics of elements, isotopes, and small shelly fossils were investigated for Late Ediacaran to Early Cambrian stratigraphy division and to discuss their geological implications in the northwestern Sichuan Basin. The results reveal that small shelly fossils can be detected in the high-phosphorous section, with the concentration of phosphorus mainly ranging from 2% to 8%, suggesting that this interval belongs to the Early Cambrian, which is also consistent with the carbon isotopic composition results. In addition, the Early Cambrian is denudated in the Sichuan Basin due to tectonic movement, and the characteristics of some isotopes and small shell fossils are different from those in other basins. It can be proposed that P content can support the recognition of lithological boundaries, and the high phosphorus content can be used as a reference to identify the top and bottom boundaries of the Maidiping Formation in the study area. According to the elemental compositions in the Ediacaran Dengying Formation, the variations in Si, Al, Fe, and K contents are similar in the platform area and rift area, suggesting that the third and fourth member of the Dengying Formation are also developed in the Deyang-Anyue Rift. The results suggest that both the Deng-4 member and Maidiping Formation feature contemporaneous deposition of different facies in the northwestern Sichuan Basin. The strata consist of shale intercalated with thin carbonate rock deposits in the Deyang-Anyue Rift, while carbonate rock deposits in the platform. The Deyang-Anyue Rift expanded gradually in the Late Ediacaran and eventually filled in the Early Cambrian. The data in this study illustrate that elemental compositions, isotopes, and small shelly fossils can be combined to correlate the Late Ediacaran to Early Cambrian strata and provide new evidence for Deyang-Anyue Rift evolution. The results offer some new insights for deep oil and gas exploration in the Sichuan Basin and for the tectonic-depositional-environmental-biological synergistic evolution in the Late Ediacaran to Early Cambrian transition. [ABSTRACT FROM AUTHOR]

Objective) To investigate the effects of an infant juice canned auxiliary food on acute inflammation and antioxidant activity in young mice. (Methods) 70 mice were divided into blank group, model group, low dose group (8.697 9 g/kg), middle dose group (17.395 8 g/kg), high dose group (34.791 6 g/kg), high dose group (69.583 2 g/kg) and positive drug control group. Adopting croton oil-induced acute ear edema model in mice to evaluate the effects of juice canned supplementary food on acute inflammation in young mice; calculated the swelling rate of left ear in each group of mice except the blank group. The levels of TNF-α, IL-2, IL-6 and IL-1β in serum were detected by ELISA. HE staining was used to detect the pathological morphology of liver tissue in mice. Electronic tongue for taste analysis. The antioxidant capacity (DPPH free radical scavenging ability, *OH free radical scavenging ability of infant canned auxiliary food was determined by ultraviolet spectrophotometry. (Results) Compared with the blank group, the left ear swelling of the model group was [ABSTRACT FROM AUTHOR]

The removal of nitrogen trifluoride (NF3) is of significant importance in atmospheric chemistry, as NF3 is an important anthropogenic greenhouse gas. However, the radical species OH and O(1D) in atmospheric conditions are nonreactive towards NF3. It is necessary to explore possible ways to remove NF3 in atmosphere. Therefore, the participation of water molecules in the reaction of NF3 with OH was discussed, as water is abundant in the atmosphere and can form very stable complexes due to its ability to act as both a hydrogen bond donor and acceptor. Systemic DFT calculations carried out at the CBS-QB3 and ωB97XD/aug-cc-pVTZ level of theory suggest that water molecules could affect the NF3 + OH reaction as well. The energy barrier of the SN2 mechanism was decreased by 8.52 kcal/mol and 10.58 kcal/mol with the assistance of H2O and (H2O)2, respectively. Moreover, the presence of (H2O)2 not only reduced the energy barrier of the reaction, but also changed the product channels, i.e., formation of NF2O + (H2O)2-HF instead of NF2OH + (H2O)2-F. Therefore, the removal of NF3 by reaction with OH is possible in the presence of water molecules. The results presented in this study should provide useful information on the atmospheric chemistry of NF3. [ABSTRACT FROM AUTHOR]

H2V3O8 has been regarded as a compelling cathode material for aqueous zinc-ion batteries (AZIBs) owing to its elevated theoretical capacity, abundance of vanadium valence states, and advantageous layered configuration. Nonetheless, the intrinsically low conductivity and sluggish ionic reaction kinetics of H2V3O8 result in undesirable, constraining its broader implementation in AZIBs. In this study, a facile hydrothermal approach was utilized to prepare H2V3O8 nanowires with an abundance of oxygen vacancies. The combination of nanowire nanostructure and oxygen vacancies of the H2V3O8 offer improved ion diffusion kinetics and enhanced electronic conductivity, leading to a superior improved electrochemical performance. Particularly, the H2V3O8 nanowire cathodes with the optimal oxygen vacancy concentration (HVO-20) exhibit a specific capacity of 461.7 mAh g−1 at 0.3 A g−1 and exceptional cycle life of 198.8 mAh g−1 after 1000 cycles at 1.0 A g−1. The investigation unveils the impact of oxygen vacancy vanadium-based oxides on the performance of AZIBs, presenting a viable strategy for advanced cathode materials in AZIBs. [ABSTRACT FROM AUTHOR]

The aim of this work was to explore the influence of temperature on the structural composition and catalytic activity of ZrO2–SnO2 catalysts for direct conversion of CO2 to dimethyl carbonate (DMC). ZrO2–SnO2 were prepared via a template-precipitation method and characterized by SEM, XRD, Raman spectroscopy, XPS, NH3/CO2-TPD, and N2 adsorption/desorption isotherms. The results showed that the calcination and hydrothermal temperature had opposite effects on the acid-base site and oxygen vacancy number of catalysts, and also have different effects on the crystal and pore structure. That confirmed that temperature had a significant impact on the studied catalysts. Furthermore, the effects of reaction conditions on the yield of DMC were investigated. The optimum reaction conditions were the catalyst amount of 0.8 g, temperature of 150°C, and time of 20 h, and the corresponding DMC yield was 1.85 mmol/(g catalyst). Thus, this work validated the temperature control strategy of catalyst preparation. [ABSTRACT FROM AUTHOR]

Understanding settling motion of coral grains is important in terms of protection of coral reef systems and resotoration of the associated ecosystems. In this paper, a series of laboratory experiments was conducted to investigate the settling motion, using optical microscopy to measure shape parameters of coral grains and the particle-filtering-based object tracking to reconstruct the three-dimensional trajectory. Three characteristic descent regimes, namely, tumbling, chaotic and fluttering, are classified based on the three-dimensional trajectory, the spiral radius variation and the velocity spectrum. It is demonstrated that if one randomly picks up one coral grain, then the probabilities of occurrence of the three regimes are approximately $26\,\%$ , $42\,\%$ and $32\,\%$ , respectively. We have shown that first, the dimensionless settling velocity generally increases with the non-dimensional diameter and Corey shape factor and second, the drag coefficient generally decreases with the Reynolds number and Corey shape factor. Based on this, the applicability of existing models on predicting settling velocity and drag coefficient for coral grains is demonstrated further. Finally, we have proposed extended models for predicting the settling velocity. This study contributes to better understanding of settling motion and improves our predictive capacity of settling velocity for coral grains with complex geometry. [ABSTRACT FROM AUTHOR]

Since pregnant women were excluded from clinical trials for vaccines against SARS-CoV-2, the novel coronavirus disease 2019 (COVID-19), there is limited data on the safety and efficacy of vaccines in this population. This systematic review explored the safety and efficacy of mRNA vaccines in pregnant women. A literature search was performed using Ovid databases through November 2021 for all studies evaluated efficacy and safety of mRNA COVID-19 vaccines in pregnant women. A total of five studies including 42,782 women were included in the systematic review. Humoral immunity to COVID-19 was detected in pregnant women who received the vaccine and no differences found in spike-specific T-cell responses. Incidence of high-grade chronic villitis is higher in the unvaccinated group with adjusted odds ratio of.31 (.1-.97), P <.05. Vaccination in pregnant women resulted in 12.6% spontaneous abortions (SAB) with 92.3% occurring in the first trimester,.1% stillbirth (> 20 weeks gestation), 9.4% preterm birth (<37 weeks gestation), and 2.2% congenital abnormalities. The mRNA COVID-19 vaccines are immunogenic in pregnant women and no obvious safety concerns observed. There is no increased incidence of adverse reactions in pregnant women. Our finding supports that pregnant women should receive the vaccination at their earliest convenience regardless of trimester. [ABSTRACT FROM AUTHOR]

Ocean waves and Stokes drift are generated by typhoons. This study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre for Medium-Range Weather Forecasts (ECMWF) ERA5 datasets and observational data. The results revealed that the typhoon generated intense cyclones and huge typhoon waves with a maximum wind speed of 45 m/s, a minimum pressure of 955 hPa, and a maximum significant wave height of 12 m. The Stokes drift caused by typhoon waves exceeded 0.6 m/s, the Stokes depth scale exceeded 18 m, and the maximum Stokes transport reached 6 m2/s. The spatial distribution of 10-m wind speed, typhoon wave height, Stokes drift, Stokes depth, and Stokes transport during the typhoon was highly correlated with the typhoon track. The distribution along the typhoon track showed significant zonal asymmetry, with greater intensity on the right side of the typhoon track than on the left side. These findings provide important insights into the impact of typhoons on ocean waves and Stokes drift, thus improving our understanding of the interactions between typhoons and the ocean environment. This study also investigated the contribution of Stokes transport to the total net transport during typhoons using Ekman-Stokes Numbers as a comparative measure. The results indicated that the ratio of Stokes transport to the total net transport reached up to 50% within the typhoon radius, while it was approximately 30% outside the radius. Strong Stokes transport induced by typhoon waves led to divergence in the transport direction, which resulted in upwelling of the lower ocean as a compensation current. Thus, Stokes transport played a crucial role in the vertical mixing of the ocean during typhoons. The findings suggested that Stokes transport should be paid more attention to, particularly in high latitude ocean regions, where strong winds can amplify its effects. [ABSTRACT FROM AUTHOR]

Vibration is an indispensable part of the tactile perception, which is encoded to oscillatory synaptic currents by receptors and transferred to neurons in the brain. The A2 and B1 neurons in the drosophila brain postsynaptic to the vibration receptors exhibit selective preferences for oscillatory synaptic currents with different frequencies, which is caused by the specific voltage-gated Na+ and K+ currents that both oppose the variations in membrane potential. To understand the peculiar role of the Na+ and K+ currents in shaping the filtering property of A2 and B1 neurons, we develop a linearized modeling framework that allows to systematically change the activation properties of these ionic channels. A data-driven conductance-based biophysical model is used to reproduce the frequency filtering of oscillatory synaptic inputs. Then, this data-driven model is linearized at the resting potential and its frequency response is calculated based on the transfer function, which is described by the magnitude–frequency curve. When we regulate the activation properties of the Na+ and K+ channels by changing the biophysical parameters, the dominant pole of the transfer function is found to be highly correlated with the fluctuation of the active current, which represents the strength of suppression of slow voltage variation. Meanwhile, the dominant pole also shapes the magnitude–frequency curve and further qualitatively determines the filtering property of the model. The transfer function provides a parsimonious description of how the biophysical parameters in Na+ and K+ channels change the inhibition of slow variations in membrane potential by Na+ and K+ currents, and further illustrates the relationship between the filtering properties and the activation properties of Na+ and K+ channels. This computational framework with the data-driven conductance-based biophysical model and its linearized model contributes to understanding the transmission and filtering of vibration stimulus in the tactile system. [ABSTRACT FROM AUTHOR]

Temporal interference deep-brain magnetic stimulation (TI-DMS) induces rhythmic electric field (EF) in the hippocampus to normalize cognitive function. The rhythmic time series of the hippocampal EF is essential for the assessment of TI-DMS. However, the finite element method (FEM) takes several hours to obtain the time series of EF. In order to reduce the time cost, the temporal convolutional network (TCN) model is adopted to predict the time series of hippocampal EF induced by TI-DMS. It takes coil configuration and loaded current as input and predicts the time series of maximum and mean values of the left and right hippocampal EF. The prediction takes only a few seconds. The model parameter combination of kernel size and layers is selected optimally by cross-validation method. The experimental results for multiple subjects show that the R2 of all the time series predicted by the model exceed 0.98. And the prediction accuracy is even higher as the input parameters approach the training set. These results demonstrate that the adopted model can quickly predict the time series of hippocampal EF induced by TI-DMS with relatively high accuracy, which is beneficial for future clinical applications. [ABSTRACT FROM AUTHOR]

Chronic neutrophilic leukemia (CNL) is a rare type of myeloproliferative neoplasm (MPN). Due to its nonspecific clinical symptoms and lack of specific molecular markers, it was previously difficult to distinguish it from other diseases with increased neutrophils. However, the discovery of the CSF3R mutation in CNL 10 years ago and the update of the diagnostic criteria by the World Health Organization (WHO) in 2016 brought CNL into a new era of molecular diagnosis. Next-generation sequencing (NGS) technology has led to the identification of numerous mutant genes in CNL. While CSF3R is commonly recognized as the driver mutation of CNL, other mutations have also been detected in CNL using NGS, including mutations in other signaling pathway genes (CBL, JAK2, NARS, PTPN11) and chromatin modification genes (ASXL1, SETBP1, EZH2), DNA methylation genes (DNMT3A, TET2), myeloid-related transcription factor genes (RUNX1, GATA2), and splicing and RNA metabolism genes (SRSF2, U2AF1). The coexistence of these mutated genes and CSF3R mutations, as well as the different evolutionary sequences of clones, deepens the complexity of CNL molecular biology. The purpose of this review is to summarize the genetic research findings of CNL in the last decade, focusing on the common mutated genes in CNL and their clinical significance, as well as the clonal evolution pattern and sequence of mutation acquisition in CNL, to provide a basis for the appropriate management of CNL patients. [ABSTRACT FROM AUTHOR]

BACKGROUND: Citrus huanglongbing (HLB) is a devastating disease caused by Candidatus Liberibacter asiaticus (CLas) that affects the citrus industry. In nature, CLas relies primarily on Diaphorina citri Kuwayama as its vector for dissemination. After D. citri ingests CLas‐infected citrus, the pathogen infiltrates the insect's body, where it thrives, reproduces, and exerts regulatory control over the growth and metabolism of D. citri. Previous studies have shown that CLas alters the composition of proteins in the saliva of D. citri, but the functions of these proteins remain largely unknown. RESULTS: In this study, we detected two proteins (DcitSGP1 and DcitSGP3) with high expression levels in CLas‐infected D. citri. Quantitative PCR and Western blotting analysis showed that the two proteins were highly expressed in the salivary glands and delivered into the host plant during feeding. Silencing the two genes significantly decreased the survival rate for D. citri, reduced phloem nutrition sucking and promoted jasmonic acid (JA) defenses in citrus. By contrast, after overexpressing the two genes in citrus, the expression levels of JA pathway‐associated genes decreased. CONCLUSION: Our results suggest that CLas can indirectly suppress the defenses of citrus and support feeding by D. citri via increasing the levels of effectors in the insect's saliva. This discovery facilitates further research into the interaction between insect vectors and pathogens. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

The article discusses research which examined the magnitude of shared genetic components and the causality relationship between schizophrenia (SCZ) and inflammatory bowel disease (IBD). Topics include the findings of genetic pleiotropic analysis aimed to uncover shared loci, genes, or biological processes between SCZ and each of IBD, ulcerative colitis (UC), and Crohn's disease (CD) and the biological mechanism and therapeutic targets underlying these two disorders.

The Late Ediacaran to Early Cambrian marked a pivotal phase in paleoenvironmental and tectonic shifts. The Sichuan Basin, on the Yangtze platform's western edge, developed the Mianyang-Changning intracratonic sag due to Xingkai taphrogenesis. The Maidiping Formation's black shales, the initial fine-grained clastic deposits from the Early Cambrian, span the Sichuan Basin's western margin. The influence of the intracratonic sag on organic matter accumulation and paleo-marine environment evolution remains unclear. Comprehensive petrological and geochemical analyses on the Qingping section revealed three distinct members within the Maidiping Formation: black shales and silicified dolomite with shales in a restricted basin (lower member), deep-water black shales (middle member), and phosphoritic turbidite sandstone with siliceous phosphorites (upper member). The lower member's organic accumulation arose from restricted ocean circulation, leading to stratified waters and reduced oxygen at depth. The middle member's organic build-up was influenced by enhanced intracratonic sag connectivity with the open ocean, sea-level rise, and increased productivity. The submarine hydrothermal activity might have induced anoxic conditions. The upper member saw a decline in organic matter due to phosphoritic debris and oxygenation. The Maidiping Formation augments the Lower Cambrian source rock, vital for oil and gas exploration in the Sichuan Basin's western margin. [ABSTRACT FROM AUTHOR]

The current study involved the preparation of a number of MnOx/Sep catalysts using the impregnation (MnOx/Sep-I), hydrothermal (MnOx/Sep-H), and precipitation (MnOx/Sep-P) methods. The MnOx/Sep catalysts that were produced were examined for their ability to catalytically oxidize formaldehyde (HCHO). Through the use of several technologies, including N2 adsorption–desorption, XRD, FTIR, TEM, H2-TPR, O2-TPD, CO2-TPD, and XPS, the function of MnOx in HCHO elimination was examined. The MnOx/Sep-H combination was shown to have superior catalytic activities, outstanding cycle stability, and long-term activity. It was also able to perform complete HCHO conversion at 85 °C with a high GHSV of 6000 mL/(g·h) and 50% humidity. Large specific surface area and pore size, a widely dispersed active component, a high percentage of Mn3+ species, and lattice oxygen concentration all suggested a potential reaction route for HCHO oxidation. This research produced a low-cost, highly effective catalyst for HCHO purification in indoor or industrial air environments. [ABSTRACT FROM AUTHOR]

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A sequence of reddish‐orange emitting NaSrBi(1−x)TeO6:xSm3+ phosphors were successfully composited by a favorable solid‐phase chemical process. The sintering temperature is optimized as 850°C. NaSrBiTeO6 (NSBTO):Sm3+ samples were assigned to the cubic double‐perovskite structure, exhibiting the space group of Fm3¯$\bar{3}$m (225). Photoluminescence emission spectra display the main peaks at 562, 598, 645, and 705 nm at 404 nm excitation. Among them, the most intense emission peak is at 645 nm. The concentration‐quenching mechanism of Sm3+ follows the interaction between electric dipoles and quadrupoles. The asymmetric ratio (I(4G5/2‐6H9/2)/I(4G5/2‐6H5/2) of NSBTO:2 mol%Sm3+ phosphor is extracted as 4.96. The optimum NSBTO:2 mol%Sm3+ phosphor has excellent thermal stability with a remained emission intensity riches 93.61% (420 K). After testing with high‐pressure water steam at various periods, the phosphor remains chemically stable for moisture resistance. For the NSBTO:2 mol%Sm3+ phosphor, the satisfactory color purity and low correlated color temperature (CCT) are obtained with 99.9% and 1494 K, respectively. The electroluminescence spectra of the prepared red light emitting diode (LED) are in conformity with the phytochrome absorption spectra of chlorophyll a, chlorophyll b, PFR, and PR. The white light‐emitting diode (w‐LED) is also perfectly packaged, obtaining an efficient color rendering index (Ra) of 92.12 and CCT of 5553 K. These exceeding optical properties certified that NaSrBi(1−x)TeO6:xSm3+ demonstrates promising prospects and can be efficiently applied in horticultural LED applications. [ABSTRACT FROM AUTHOR]

For degree ± 1 harmonic maps from R 2 (or S 2 ) to S 2 , Bernand-Mantel et al. (Arch Ration Mech Anal 239(1):219–299, 2021) recently establish a uniformly quantitative stability estimate. Namely, for any map u : R 2 → S 2 with degree ± 1 , the discrepancy of its Dirichlet energy and 4 π can linearly control the H ˙ 1 -difference of u from the set of degree ± 1 harmonic maps. Whether a similar estimate holds for harmonic maps with a higher degree is unknown. In this paper, we prove that a similar quantitative stability result for a higher degree is true only in a local sense. Namely, given a harmonic map, a similar estimate holds if u is already sufficiently near to it (modulo Möbius transforms) and the bound in general depends on the given harmonic map. More importantly, we thoroughly investigate an example of the degree 2 case, which shows that it fails to have a uniformly quantitative estimate like the degree ± 1 case. This phenomenon shows the striking difference between degree ± 1 ones and higher degree ones. Finally, we also conjecture a new uniformly quantitative stability estimate based on our computation. [ABSTRACT FROM AUTHOR]

Background: Tegoprazan is a potassium-competitive acid blocker that inhibits gastric acid and which may be used for eradicating Helicobacter pylori. This study focuses on the pharmacokinetic interaction and safety between tegoprazan and the combination of clarithromycin, amoxicillin and bismuth in healthy Chinese subjects. Methods: An open-label, three-period, single-center, multiple-dosage, single-sequence, phase I trial was conducted in 22 healthy subjects. In period 1, the subjects took tegoprazan 50 mg twice daily for 7 days, and in period 2 they were administered clarithromycin 500 mg, amoxicillin 1000 mg and bismuth potassium citrate 600 mg twice daily for 7 days (days 14–20). Tegoprazan, clarithromycin, amoxicillin and bismuth potassium citrate were then administered in combination for 7 days (days 21–27) in period 3. Blood samples were collected up to 12 h after the last dose of each period. Safety assessments were performed in each period. Results: The geometric mean ratios (GMRs) [90% confidence interval (CI)] of maximum plasma concentration at steady state (Cmax,ss) and area under the plasma concentration–time curve over the dosing interval (AUCτ) at steady state were 195.93% (175.52–218.71%) and 287.54% (263.28–314.04%) for tegoprazan and 423.23% (382.57–468.22%) and 385.61% (354.62–419.30%) for tegoprazan metabolite M1, respectively. The GMRs (90% CI) of Cmax,ss and AUCτ were 83.69% (77.44–90.45%) and 110.30% (102.74–118.41%) for clarithromycin, 126.25% (114.73–138.93%) and 146.94% (135.33–159.55%) for 14-hydroxyclarithromycin, 75.89% (69.73–82.60%) and 94.34% (87.94–101.20%) for amoxicillin, and 158.43% (125.43–200.11%) and 183.63% (156.42–215.58%) for bismuth, respectively. All reported adverse events were mild. The frequency of adverse events during the coadministration stage was not higher than that during the single- or triple-drug administration stages. Conclusion: The plasma exposure of tegoprazan, M1, 14-hydroxyclarithromycin and bismuth was increased after the coadministration of tegoprazan, clarithromycin, amoxicillin and bismuth. The coadministration exhibited favorable safety and tolerability. Clinical Trials Registration: CTR20230643. [ABSTRACT FROM AUTHOR]

The Middle Permain Maokou Formation (P2m) is a new region of natural gas exploration in the Sichuan Basin, is characterized by bioclastic limestone with localized dolomitization, and karst fractured-vuggy reservoirs. Currently, on the gas source, hydrocarbon accumulation process and control factors in the Sichuan Basin during the Permian are lacking. To bridge this gap, herein, we identified the filling sequence minerals inside the pores/vugs, along with the oil charge of the Maokou Formation using drill cores, thin sections, oil inclusion analysis, and U-Pb dating of calcite cements. The results showed that the reservoir space of the Maokou Formation was predominated by the residual dissolved pores/vugs, fractures, and dissolved fractures. The pores/vugs underwent four stages of mineral filling by very fine-fine (-crystalline, CC1) calcite ^ fine-medium calcite (CC2: from 256.4 ± 1.7 to 244.1 ± 6.3 Ma) ^ fibrous calcite (FC; -183.9 ± 8.2 Ma) ^ coarse-macro calcite (CC3; -171.5 ± 5.3 Ma). Combined with the homogenization temperature and salty of fluid inclusion, we considered that three stages of oil charge were present in the Maokou Formation reservoirs. The first stage involved the formation of paleo-oil reservoirs during the Late Permian to Early Triassic, corresponding to the high-maturity aqueous inclusions in CC2, with a homogenization temperature of 106.7°C-137.8°C. At that time, the oil generation from the Lower Cambrian Qiongzhusi Formation rocks peaked, and the generated hydrocarbons migrated upward into the Maokou Formation through the strike-slip faults in the basin center. The second stage involved the formation of paleo-oil reservoirs during the Early Jurassic. The Permian source rocks reached the oil generation window with hydrocarbon expulsion, which was consistent with the oil inclusions in FC. The third stage involved the formation of paleo-gas reservoirs during the Middle Jurassic to Early Cretaceous, corresponding to the high-density methane inclusions and bitumen inclusions occurring in CC3, with the homogenization temperature peaking at 151.9°C-178°C. The natural gas in the Middle Permian of the Central Sichuan Basin is predominantly sourced from the Lower Cambrian Qiongzhusi Formation mudstone and partially from the source rocks of the Middle Permian, indicating a significant source-reservoir conduit of the strike-slip faults in the basin center. The findings provide considerable baseline data to advance further research in the Sichuan Basin. [ABSTRACT FROM AUTHOR]

Objective: The connection between alterations in the disc structure following percutaneous endoscopic lumbar discectomy (PELD) and symptoms in patients postsurgery has not been reported yet. The purpose of the present study was to discuss the potential correlation between the changes in the morphological characteristics of various reference surfaces of the intervertebral disc after percutaneous endoscopic lumbar discectomy (PELD) and clinical outcomes, to identify the morphological parameters that affect efficacy and provide an evidence‐based foundation for assessing postoperative efficacy. Methods: From October 2019 to October 2021, after percutaneous endoscopic lumbar discectomy (PELD), 98 individuals were enrolled. MRI DICOM data of the lumbar spine were obtained before and after surgery, specifically around 3 months. The morphological parameters of the operated and adjacent segments of the discs were measured using T2‐weighted images from three reference planes. Outcomes were assessed using the Oswestry disability index (ODI), visual analogue pain scores for the back and leg (VAS‐back/VAS‐leg), Japanese Orthopaedic Association (JOA) scores, and recovery rates. Postoperative changes in disc parameters and outcomes were compared between patients with different severity and types of LDH based on the MSU staging. Patients completed the questionnaire during outpatient follow‐up appointments 3, 6, and 12 months after the surgery. The follow‐up period was 14.69 ± 4.21 months, ranging from 12 to 24 months. Results: Parameters such as area and circumference of intervertebral discs in the cross‐section were not associated with the change in the efficacy index. Postoperatively, a negative correlation between the variation of the disc height, disc height index, and protrusion distance and the difference in VAS scores for low back pain at 3 and 6 months was observed among the two sagittal change parameters. Differences between changes in disc imaging parameters and postoperative efficacy were not statistically significant between various types of lumbar disc herniation. Conclusion: For the patients after percutaneous endoscopic lumbar discectomy, the changes in parameters such as disc area and circumference in the cross‐sectional plane are not associated with efficacy, and the changes in disc height and herniation distance in the sagittal plane provide a morphologic basis for the assessment of short‐term postoperative efficacy. In addition, the changes in disc morphologic parameters and postoperative efficacy do not differ between various types of lumbar disc herniation. [ABSTRACT FROM AUTHOR]

Audio data augmentation is widely adopted in automatic speech recognition (ASR) to alleviate the overfitting problem. However, noise-based data augmentation converts an over-fitting problem into an under-fitting problem which increases the training time severely. With noise-based data augmentation, informative features are not be persisted during the generating process and generated audio clips would become noise data for the acoustic model. To face the challenge, we propose an Adaptive audio Data Augmentation method called ADA with deep clustering. The proposed ADA could automatically select the most informative augmented sample for each generation. Moreover, two sample selection strategies called RM and RS are proposed. The proposed RM removes samples whose embedding are far away from the cluster center, while the proposed RS maintains the diversity of augmentation samples by sampling in each cluster. Experiments on Aishell-1 demonstrate that the proposed ADA method could improve the data efficiency of end-to-end ASR model in both CNN-based and Transformer-based networks. The proposed ADA obtains an 11.28% and 5.95% relative improvement on SS-CNN and LS-CNN, and a 4.35% improvement on S-Transformer compared with the state-of-the-art audio data augmentation method. Meanwhile, the proposed ADA method decreases the demand of augmented samples by 2.7 times in SS-CNN, LS-CNN and S-Transformer. The qualitative and quantitative analysis proves the effectiveness and efficiency of the proposed ADA method. [ABSTRACT FROM AUTHOR]

NADH cytochrome b5 oxidoreductase (Ncb5or) is a cytosolic ferric reductase implicated in diabetes and neurological conditions. Ncb5or comprises cytochrome b5 (b5) and cytochrome b5 reductase (b5R) domains separated by a CHORD‐Sgt1 (CS) linker domain. Ncb5or redox activity depends on proper inter‐domain interactions to mediate electron transfer from NADH or NADPH via FAD to heme. While full‐length human Ncb5or has proven resistant to crystallization, we have succeeded in obtaining high‐resolution atomic structures of the b5 domain and a construct containing the CS and b5R domains (CS/b5R). Ncb5or also contains an N‐terminal intrinsically disordered region of 50 residues that has no homologs in other protein families in animals but features a distinctive, conserved L34MDWIRL40 motif also present in reduced lateral root formation (RLF) protein in rice and increased recombination center 21 in baker's yeast, all attaching to a b5 domain. After unsuccessful attempts at crystallizing a human Ncb5or construct comprising the N‐terminal region naturally fused to the b5 domain, we were able to obtain a high‐resolution atomic structure of a recombinant rice RLF construct corresponding to residues 25–129 of human Ncb5or (52% sequence identity; 74% similarity). The structure reveals Trp120 (corresponding to invariant Trp37 in Ncb5or) to be part of an 11‐residue α‐helix (S116QMDWLKLTRT126) packing against two of the four helices in the b5 domain that surround heme (α2 and α5). The Trp120 side chain forms a network of interactions with the side chains of four highly conserved residues corresponding to Tyr85 and Tyr88 (α2), Cys124 (α5), and Leu47 in Ncb5or. Circular dichroism measurements of human Ncb5or fragments further support a key role of Trp37 in nucleating the formation of the N‐terminal helix, whose location in the N/b5 module suggests a role in regulating the function of this multi‐domain redox enzyme. This study revealed for the first time an ancient origin of a helical motif in the N/b5 module as reflected by its existence in a class of cytochrome b5 proteins from three kingdoms among eukaryotes. [ABSTRACT FROM AUTHOR]

The surrounding rock in deep underground engineering is often subjected to true three-dimensional high-stress conditions. Excavation unloading results in changes in the stress state and induces damage in the surrounding rock, subsequently, dynamic disturbance triggers catastrophic in the damaged surrounding rock and increases the risk of engineering. Therefore, it is necessary to elucidate the dynamic mechanical behavior and fracture evolution mechanisms of deep surrounding rock. In this study, a novel three-stage true triaxial static-dynamic coupling loading test method was proposed to model stress paths experienced by the rock during disturbance failure after excavation damage in deep engineering. With acoustic emission (AE) monitoring, a set of true triaxial tests was conducted to investigate the influence of initial damage degree on the disturbance mechanical properties and failure mechanisms of monzogabbro, including bearing capacity, deformation, macro and mesoscopic fracture characteristics, and anisotropic disturbance fracture evolution mechanisms. AE activity can reflect the disturbance failure processes (decay stage, steady stage, and accelerated stage), and tensile-shear mechanisms evolution based on AE parameters AF/RA are well investigated. The disturbance critical stress is defined and calculated based on the disturbance life, and it can be used as the criterion for rock disturbance failure. The transition conditions of disturbance deformation in three stages can be linked with static strains corresponding to damage stress and peak strength under true triaxial stress. When initial damage degree increases from 80 to 93% of peak strength, disturbance life of monzogabbro decreases by 98%, deformation differential index DI values increases by 31%, and the disturbance failure mode changes from localized tensile splitting failure/ tensile-shear mixed failure to macroscopic shear failure. The study also explores the implications of initial damage degree on the disturbance fracture mechanisms of different buried depths and deteriorated surrounding rock. Highlights: A novel three-stage true triaxial static-dynamic coupling loading (TTSDC) test method is proposed for modelling the excavation-induced damage and then far-field disturbance fracture of surrounding rock in deep engineering. With the increase of initial damage degree, the disturbance life of monzogabbro decreases, and the disturbance failure mode changes from localized tensile splitting failure/tensile-shear mixed failure to macroscopic shear failure. A new differential index is proposed to characterize the influence of initial damage degree on disturbance deformation anisotropy. The tensile-shear mechanism during disturbance failure evolution is well investigated with AE parameters. The triggering conditions of rock disturbance failure evolution under true triaxial stress are interpreted. [ABSTRACT FROM AUTHOR]

Summary: The Aquila optimizer (AO) is an efficient method for solving global optimization problems. However, the evolution of each individual learns from experience in the same group, which can easily fall into local optima. Therefore, this paper adopts the dynamic grouping strategy (DGS) of the population and proposes an improved AO algorithm to solve the global optimization problem. Different from the original AO algorithm, the DGSAO algorithm only evolves the individuals with the worst fitness in each group each time, which increases the diversity of the population. In order to verify the effectiveness of the algorithm, we tested it on 23 benchmark functions, among which the dimensions of F1$$ {F}_1 $$ to F13$$ {F}_{13} $$ are 30, 100, and 200 dimensions. The experimental results show that the DGSAO algorithm is an effective method for solving global optimization problems. At the same time, we also conduct experiments on two engineering design problems, and the results show that the DGSAO algorithm can obtain a competitive result. [ABSTRACT FROM AUTHOR]

Plate subduction leads to complex exhumation processes on continents. The Huangling Massif lies at the northern margin of the South China Block. Whether the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo‐Yangtze River during the Mesozoic remains under debate. We examined the exhumation history of the Huangling Massif based on six granite bedrock samples, using apatite fission track (AFT) and apatite and zircon (U‐Th)/He (AHe and ZHe) thermochronology. These samples yielded ages of 157–132 Ma (ZHe), 119–106 Ma (AFT), and 114–72 Ma (AHe), respectively. Thermal modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous, late Early Cretaceous, and Late Cretaceous. These exhumation processes led to the high topographic relief responsible for the emergence of the Huangling Massif. The integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo‐Yangtze River since the Cretaceous. At that time, the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan Basin. The subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block. [ABSTRACT FROM AUTHOR]

This study utilized 50 laboratory experiments to document the evolution of coral beaches under varying regular wave conditions, including five distinct wave periods and ten wave heights. Both the type of equilibrium beach and the shape of sand bars were used to represent beach evolution. The evolution of coral sand beaches was then compared to quartz sand beaches. The experimental results show that the predicted (modeled) equilibrium profile of a quartz sand beach was not applicable to coral sand beaches. Compared to sand bars on quartz sand beaches, the distance from bar crests to the beach berm in coral sand beaches was greater, whereas the erosional depth of sand troughs was deeper. However, the grain size distribution of sand associated with the coral sand beach under wave action was consistent with Celikoglu's law. Both an equilibrium beach profile classification model and a sand bar shape prediction model for coral sand beaches were developed based on the experimental data. [ABSTRACT FROM AUTHOR]

Background: Type 2 diabetes (T2DM) combined nonalcoholic fatty liver disease (NAFLD) are characterized by metabolic disruptions. Liraglutide has been proved to be effective in T2DM. If LRG could regulate NAFLD combined T2DM has not been reported. Methods: Intraperitoneal injection of 1% streptozotocin (STZ) plus high-sugar and high-fat diet was used to induce NAFLD combined T2DM animal model. Palmitic acid (200 μmol/L) and glucose (25 mmol/L) incubation were used to induce cell model. The cell apoptosis, mRNA and protein expression were measured through flow cytometry, PCR, and Western blotting, respectively. Results: Liraglutide significantly improved the liver injury of NAFLD combined T2DM rats, but Com-C reversed the effect of liraglutide. The decreased AMPK/mTOR signaling pathway in the NAFLD combined T2DM animals was greatly activated by liraglutide. Com-C reversed the protection effects of liraglutide on palmitic acid+glucose induced cell damage. Conclusion: Liraglutide could greatly alleviate the damage caused by NAFLD+T2DM and palmitic acid+glucose. The protection effects of liraglutide were greatly inhibited by suppressing AMPK/mTOR signaling pathway. This research might provide a novel therapeutic strategy for the prevention and treatment of NAFLD combined T2DM disease. [ABSTRACT FROM AUTHOR]

Facing the shortage of special building materials packaging machinery with thermal insulation and low intelligence, this paper designs a set of mechanical and electrical integration packaging unit control system to reduce the risk of material transportation for different stakeholders. According to risk management tools, the system takes Mitsubishi PLC as the control core and combines with communication module, servo motor drive system and touch screen man–machine interface to realize the risk simulation and automatic control of the packaging unit. The simulation results of PID control model show that the parameters such as speed and torque can be stabilized in a relatively short period of time when the load is suddenly changed within 1.5 s. Theoretical verification of the system has small steady-state error, rapid response, and good control effect. The man–machine interface design was carried out and the actual corresponding test experiment was carried out. The experimental results showed that the overall operation rate of the packaging unit system reached 98.15%, the pass rate was 99.03%, and the production capacity was about 9600 packs/hour, which met the production requirements. The control system of the building material packaging unit designed in this paper realizes the equipment intelligence, has a high degree of automation, and shows good potential application value in the aspects of building information, reduction of construction risks and manufacturing intelligence. [ABSTRACT FROM AUTHOR]

Cisplatin-based chemotherapy is the main treatment option for advanced or metastatic esophageal squamous cell carcinoma (ESCC). However, most ESCC patients develop drug resistance within 2 years after receiving cisplatin chemotherapy. Ubiquitin-specific protease 10 (USP10) is abnormally expressed in a variety of cancers, but the mechanistic roles of USP10 in ESCC are still obscure. Here, the effects of USP10 on the migration and cisplatin resistance of ESCC in vivo and in vitro and the underlying mechanisms have been investigated by bioinformatics analysis, RT-PCR, western blotting, immunoprecipitation, immunohistochemistry, cell migration and MTS cell proliferation assays, deubiquitination assay, and mouse tail vein injection model. USP10 was significantly up-regulated in ESCC tissues compared with adjacent normal tissues in both public databases and clinical samples and was closely associated with overall survival. Subsequent results revealed that USP10 contributed to the migration and cisplatin resistance of ESCC cells, while knocking down USP10 in cisplatin-resistant cells exhibited opposite effects in vitro and in vivo. Further Co-IP experiments showed that integrin β1 and YAP might be targets for USP10 deubiquitination. Moreover, deficiency of USP10 significantly inhibited the migrative and chemo-resistant abilities of ESCC cells, which could be majorly reversed by integrin β1 or YAP reconstitution. Altogether, USP10 was required for migration and cisplatin resistance in ESCC through deubiquinating and stabilizing integrin β1/YAP, highlighting that inhibition of USP10 may be a potential therapeutic strategy for ESCC. [ABSTRACT FROM AUTHOR]

Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses significant risks, leading to severe complications in immunocompromised individuals and potentially affecting the fetus through congenital transmission. A comprehensive understanding of the intricate molecular interactions between T. gondii and its host is pivotal for the development of effective therapeutic strategies. This review emphasizes the crucial role of proteomics in T. gondii research, with a specific focus on host–parasite interactions, post-translational modifications (PTMs), PTM crosstalk, and ongoing efforts in drug discovery. Additionally, we provide an overview of recent advancements in proteomics techniques, encompassing interactome sample preparation methods such as BioID (BirA*-mediated proximity-dependent biotin identification), APEX (ascorbate peroxidase-mediated proximity labeling), and Y2H (yeast two hybrid), as well as various proteomics approaches, including single-cell analysis, DIA (data-independent acquisition), targeted, top-down, and plasma proteomics. Furthermore, we discuss bioinformatics and the integration of proteomics with other omics technologies, highlighting its potential in unraveling the intricate mechanisms of T. gondii pathogenesis and identifying novel therapeutic targets. [ABSTRACT FROM AUTHOR]

Background: Type 2 diabetes mellitus (T2DM) induced diabetes-associated cognitive dysfunction (DACD) that seriously affects the self-management of T2DM patients, is currently one of the most severe T2DM-associated complications, but the mechanistic basis remains unclear. Mitochondria are highly dynamic organelles, whose function refers to a broad spectrum of features such as mitochondrial dynamics, mitophagy and so on. Mitochondrial abnormalities have emerged as key determinants for cognitive function, the relationship between DACD and mitochondria is not well understood. Methods: Here, we explored the underlying mechanism of mitochondrial dysfunction of T2DM mice and HT22 cells treated with high glucose/palmitic acid (HG/Pal) focusing on the mitochondrial fission-mitophagy axis with drug injection, western blotting, Immunofluorescence, and electron microscopy. We further explored the potential role of caveolin-1 (cav-1) in T2DM induced mitochondrial dysfunction and synaptic alteration through viral transduction. Results: As previously reported, T2DM condition significantly prompted hippocampal mitochondrial fission, whereas mitophagy was blocked rather than increasing, which was accompanied by dysfunctional mitochondria and impaired neuronal function. By contrast, Mdivi-1 (mitochondrial division inhibitor) and urolithin A (mitophagy activator) ameliorated mitochondrial and neuronal function and thereafter lead to cognitive improvement by inhibiting excessive mitochondrial fission and giving rise to mitophagy, respectively. We have previously shown that cav-1 can significantly improve DACD by inhibiting ferroptosis. Here, we further demonstrated that cav-1 could not only inhibit mitochondrial fission via the interaction with GSK3β to modulate Drp1 pathway, but also rescue mitophagy through interacting with AMPK to activate PINK1/Parkin and ULK1-dependent signlings. Conclusions: Overall, our data for the first time point to a mitochondrial fission-mitophagy axis as a driver of neuronal dysfunction in a phenotype that was exaggerated by T2DM, and the protective role of cav-1 in DACD. Graphic Summary Illustration. In T2DM, excessive mitochondrial fission and impaired mitophagy conspire to an altered mitochondrial morphology and mitochondrial dysfunction, with a consequent neuronal damage, overall suggesting an unbalanced mitochondrial fission-mitophagy axis. Upon cav-1 overexpression, GSK3β and AMPK are phosphorylated respectively to activate Drp1 and mitophagy-related pathways (PINK1 and ULKI), ultimately inhibits mitochondrial fission and enhances mitophagy. In the meantime, the mitochondrial morphology and neuronal function are rescued, indicating the protective role of cav-1 on mitochondrial fission-mitophagy axis. 4fVNd5UMHP9GEmZKs4s8VH Video Abstract [ABSTRACT FROM AUTHOR]

Myc is a pivotal protooncogenic transcription factor that contributes to the development of almost all Burkitt's lymphomas and about one-third of diffuse large B-cell lymphomas. How B-cells sustain their uncontrolled proliferation due to high Myc is not yet well defined. Here, we found that Myc trans-represses the expression of murine LAPTM5, a gene coding a lysosome-associated protein, by binding to two E-boxes in the LAPTM5 promoter. While the product of intact mRNA (CDS+3′UTR) of LAPTM5 failed to suppress the growth of B-lymphomas, either the protein coded by coding sequence (CDS) itself or the non-coding 3′-untranslated region (3′UTR) mRNA was able to inhibit the growth of B-lymphomas. Moreover, Myc trans-activated miR-17-3p, which promoted tumor growth. Strikingly, LAPTM5 3′UTR contains 11 miR-17-3p-binding sites through which the LAPTM5 protein synthesis was inhibited. The functional interplay between low LAPTM5 mRNA and high miR-17-3p due to high Myc in B-lymphomas leads to further dampening of tumor-suppressive LAPTM5 protein, which promotes tumor progression. Our results indicate that Myc inhibits LAPTM5 expression in B-lymphoma cells by transcriptional and post-transcriptional modifications. [ABSTRACT FROM AUTHOR]

In this paper, we use the maximum principle and moving frame technique to prove the global gradient estimates for the higher-order curvature equations with prescribed contact angle problems. [ABSTRACT FROM AUTHOR]

The controversial wear resistance limits the application of the nitro-chromizing process, which is a potential advanced chromizing strategy with a low chromizing temperature and thick strengthening layer. In this study, additional carburizing was proposed to optimize the nitro-chromizing process and the associated wear resistance. Samples of carbon steel were used to evaluate the optimized nitro-chromizing, normal nitro-chromizing, and other relevant processes. Comparative analyses were conducted through XRD composition analysis, microstructure observations, and mechanical property tests.The results confirm that the normal nitro-chromized sample has poor wear resistance due to severe abrasive wear, while the wear rate of the optimized nitro-chromized sample is only about 1/15 of that of the normal nitro-chromized sample. Both the above two samples have similar main phase compositions of Cr2N and Cr7C3. However, the optimized nitro-chromized sample exhibits a lower friction coefficient and better adhesion strength than the normal nitro-chromized sample. The additional carburizing induces the formation of massive fine graphite sheets deposited on porous nitriding structures, which can be in charge of the low friction coefficient and good adhesion strength. [ABSTRACT FROM AUTHOR]

Although doxorubicin (DOX) is an efficient chemotherapeutic drug for human tumors, severe cardiotoxicity restricts its clinical use. Cinnamaldehyde (CA), a bioactive component isolated from Cinnamonum cassia, possesses potent anti-oxidative and anti-apoptotic potentials. The major aim of this study was to evaluate the protective role of CA against DOX-induced cardiotoxicity. To this end, cardiomyocyte injury models were developed using DOX-treated H9c2 cells and DOX-treated rats, respectively. Herein, we found that CA treatment increased cardiomyocyte viability and attenuated DOX-induced cardiomyocyte death in vitro. CA further protected rats against DOX-induced cardiotoxicity, as indicated by elevated creatine kinase (CK) and lactate dehydrogenase (LDH) levels, myocardium injury, and myocardial fibrosis. CA alleviated DOX-induced myocardial oxidative stress by regulating reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels. Mechanistically, CA markedly accelerated nuclear translocation of nuclear erythroid factor 2-related factor 2 (Nrf2) and increased heme oxygenase-1 (HO-1) expression. Consequently, CA decreased DOX-induced cardiomyocyte ferroptosis, while Erastin (a ferroptosis agonist) treatment destroyed the effect of CA on increasing cardiomyocyte viability. Taken together, the current results demonstrate that CA alleviates DOX-induced cardiotoxicity, providing a promising opportunity to increase the clinical application of DOX. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to compare the short-term surgery outcomes of the resection of meningiomas and clinical characteristics between elderly and non-elderly patients.Patients and Methods: This retrospective study included patients who underwent a resection of middle third parasagittal and parafalcine meningiomas between January 2011 and December 2020. All lesions arise from the middle third of the parafalcine or infiltrate superior sagittal sinus (SSS). The clinical characteristics studied included neurological deficit, peritumoral brain edema (PTBE), SSS invasion, tumor size, and symptoms; perioperative complications, and short-term surgery outcomes including neurological deficit, operative blood loss, postoperative hospitalization duration, and WHO classification were compared.Results: A total of 43 elderly patients and 63 non-elderly patients were included. Compared with non-elderly patients, elderly patients had larger lesions (P = 0.013) and presented with a larger PTBE (P = 0.019). SSS blockage was identified in 28.57% of elderly patients and 19.57% of non-elderly patients. Compared with non-elderly patients, elderly patients tended to suffer from more aggressive lesions (WHO II/III meningioma 6 vs 3, P = 0.154) and presented with longer postoperative hospital stays (17.25 ± 5.8 vs 13.50 ± 3.8, P = 0.009); conversely, while the non-elderly patients experienced more blood loss (P = 0.022) and had more perioperative reoperations (3 vs 1). No significant difference in neurological deficit was detected between the two groups (P = 0.97). After total tumor resection, patients with neurological deficits in both groups can recover during the follow-up period.Conclusion: Among the 106 patients with middle third parasagittal and falx meningiomas in our hospital, elderly patients had larger lesions, presented with more severe PTBE, and had longer postoperative hospital stays than younger patients. Conversely, younger patients had more blood loss and serious complications than elderly patients. Postoperative neurological dysfunction in elderly patients was similar to that in middle-aged and young patients. [ABSTRACT FROM AUTHOR]

Paired immunoglobulin-like receptor B (PirB) was identified as a myelin-associated inhibitory protein (MAIP) receptor that plays a critical role in axonal regeneration, synaptic plasticity and neuronal survival after stroke. In our previous study, a transactivator of transcription-PirB extracellular peptide (TAT-PEP) was generated that can block the interactions between MAIs and PirB. We found that TAT-PEP treatment improved axonal regeneration, CST projection and long-term neurobehavioural recovery after stroke through its effects on PirB-mediated downstream signalling. However, the effect of TAT-PEP on the recovery of cognitive function and the survival of neurons also needs to be investigated. In this study, we investigated whether pirb RNAi could alleviate neuronal injury by inhibiting the expression of PirB following exposure to oxygen–glucose deprivation (OGD) in vitro. In addition, TAT-PEP treatment attenuated the volume of the brain infarct and promoted the recovery of neurobehavioural function and cognitive function. This study also found that TAT-PEP exerts neuroprotection by reducing neuronal degeneration and apoptosis after ischemia–reperfusion injury. In addition, TAT-PEP improved neuron survival and reduced lactate dehydrogenase (LDH) release in vitro. Results also showed that TAT-PEP reduced malondialdehyde (MDA) levels, increased superoxide dismutase (SOD) activity and reduced reactive oxygen species (ROS) accumulation in OGD-injured neurons. The possible mechanism was that TAT-PEP could contribute to the damage of neuronal mitochondria and affect the expression of cleaved caspase 3, Bax and Bcl-2. Our results suggest that PirB overexpression in neurons after ischaemic-reperfusion injury induces neuronal mitochondrial damage, oxidative stress and apoptosis. This study also suggests that TAT-PEP may be a potent neuroprotectant with therapeutic potential for stroke by reducing neuronal oxidative stress, mitochondrial damage, degeneration and apoptosis in ischemic stroke. [ABSTRACT FROM AUTHOR]

The problem studied in this paper is the maximin share fair allocation of multiple resources in a cloud-edge collaborative computing system with bandwidth demand compression. For this problem, we propose a mechanism called maximin share fairness (MMS-BC) with bandwidth demand compression in the computing system. The MMS-BC mechanism provides two ways for each user to process tasks in the computing system: the user directly uploads the task to the cloud server for processing and storage, and the user first transfers the task to the edge server for processing and then uploads it to the cloud server for storage. When users handle the same task in two different ways, the bandwidth resources consumed by the two methods are definitely different. The bandwidth demand compression comes from this. The MMS-BC mechanism satisfies the following four commonly used properties: Pareto efficiency, envy-freeness, proportionality and strategy-proofness. To evaluate the performance of MMS-BC, we conduct a simulation experiment with a small-scale dataset and Alibaba cluster traces. The experimental results indicate that MMS-BC outperforms other similar mechanisms in terms of resource utilization, the number of tasks users can process, and runtime. Additionally, we conducted experiments on the impact of bandwidth demand compression on the mechanism. Experiments show that the mechanism with bandwidth demand compression greatly improves the number of tasks that users can process and resource utilization. [ABSTRACT FROM AUTHOR]

In recent years, terahertz (THz) radar has been widely researched for its high-resolution imaging. However, the traditional inverse synthetic aperture radar (ISAR) imaging algorithms in the microwave band perform unsatisfactorily in the THz band. Firstly, due to THz radar's large bandwidth and short wavelength, the rotation of the target will result in serious space-varying(SV) range migration and space-varying phase error. Furthermore, it is challenging to accurately estimate the rotational velocity and compensate for phase errors in the presence of severe range migration effects. Therefore, in this paper, a high-precision THz-ISAR imaging algorithm is proposed. The algorithm includes the following step: First, the SV first-order range migration(FRM) is corrected using keystone transform (KT); then, the minimum entropy based on modified newton (ME-MN) is used to estimate the rotational velocity roughly, and the remaining SV second-order range migration(SRM) is corrected to obtain the range profile with the envelope alignment. Finally, the echo after the envelope alignment is processed for the second time based on ME-MN. The target rotation velocity is accurately estimated, and the phase error is compensated to obtain a well-focused imaging result. The validity of the proposed method is verified by numerical simulation and electromagnetic calculation data. [ABSTRACT FROM AUTHOR]