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Autoimmune gastritis (AIG) is an immuno-mediated disease characterized by the production of antibodies to the parietal cells of the stomach, which leads to the loss of the internal Castle factor and decrease in the production of hydrochloric acid. Diagnosis of AIG remains difficult due to the lack of symptoms at early stages, ineffective or costly screening strategies, and incomplete established etiology. Patients with AIG are at high risk of developing malignant neoplasms and neuroendocrine tumors, and they would greatly benefit from any means to predict the likelihood of developing and the severity of a possible disease. Here, we aim to summarize data on the genetic nature of AIG. We will also describe the clinical picture of AIG, Helicobacter pylori association with it, and elaborate on the pathogenesis of the disease. [ABSTRACT FROM AUTHOR]

Background: Varieties of methods are used to close the skin. Traditionally sutures (SS) have been used to close the skin but more recently metal staples (SC) were introduced with aim to reduce closure time and infection rates. Objective: We aim to assess the difference between clips and sutures in elective colorectal surgery in terms of wound infection, cosmetic result and overall patient satisfaction. Methods: Prospective case controlled cohort study including all the patients who underwent elective open colorectal surgery, data collection was achieved through anonymous patient questionnaires. Results: 218 filled questionnaires were received. 134 patients were allocated to SS group with median age of 67 (IQR 61, 74). SC group had a total of 84 patients with a median age of 69 (IQR 61, 71).15% of SS group developed wound infection, compared to 20% in SC group (p= 0.202).Over all 61% of SS group claimed excellent results compared to 46% in SC group (p=0.020). Conclusion: Our results showed that patients with non-absorbable sub-cuticular skin closure compared to clips had low infection rates, more satisfied with their scar and better cosmesis outcome. We therefore suggest using sub-cuticlar sutures to close the skin in abdominal elective open colorectal surgery. [ABSTRACT FROM AUTHOR]

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