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Objectives: To investigate whether phase angle (PhA) measured by bioelectrical impedance analysis (BIA) and frailty are associated with the outcomes of critical illnesses. Design: A single-center prospective cohort study. Setting: Medical intensive care unit (ICU) in Seoul National University Hospital, Seoul, Republic of Korea. Participants: 97 patients who were admitted to the medical ICU. Measurements: On admission, PhA was measured by BIA, and frailty was assessed by the Korean Modified Barthel Index (KMBI) scoring system. Patients were classified according to PhA and KMBI scores, and their impact on the outcomes of critical illnesses was evaluated. Results: The patients' mean age was 62.4 ± 16.4 years, and 56 of the patients (57.7%) were men. Having a high PhA above 3.5 at the time of ICU admission was associated with lower in-hospital mortality (adjusted OR 0.42, p =.042), and a shorter duration of ICU stay (5.6 days vs. 9.8 days, p =.016) compared to those with a low PhA. Other indices measured by BIA were not significantly associated with outcomes of critical illnesses. Frailty (KMBI > 60) was associated with more mechanical ventilation days (2.3 days vs. 7.1 days; p =.018). Conclusion: Both PhA and frailty are important prognostic factors predicting the outcomes of critical illnesses. Low PhA scores were associated with increased mortality and a longer duration of ICU stay, and frailty was associated with more mechanical ventilation days. [ABSTRACT FROM AUTHOR]

Background and purpose: High blood pressure (BP) at presentation is associated with poor outcomes in acute ischaemic stroke, but serial BP measurements may better delineate the clinical implications of BP. The aim was to investigate the association between various BP parameters and functional outcomes in acute ischaemic stroke patients treated with endovascular thrombectomy (EVT). Methods: This study reports a retrospective analysis of a prospective registry of a comprehensive stroke centre. Patients treated with EVT due to large vessel occlusion in the anterior circulation were enrolled. BP was measured hourly during the first 24 h after admission. Associations of various BP parameters, including BP variability, with functional outcomes at 3 months, including good outcomes (modified Rankin Scale score of 0–2), were analysed. Results: Of the 378 enrolled patients (mean age 70 ± 11 years, male 54.2%), 313 (82.8%) achieved successful reperfusion after EVT, and 149 (39.4%) had good outcomes at 3 months. Higher mean systolic BP [each 10 mmHg increase, odds ratio 0.82 (0.69–0.97)] and higher systolic successive variation (SV) [each 10% increase, odds ratio 0.37 (0.18–0.76)] were associated with a reduced likelihood of achieving good outcomes. In addition, reperfusion status after EVT moderated the influence of higher systolic SV on good outcomes (Pint = 0.05). Conclusion: The results showed that a higher mean systolic BP and systolic SV during the first 24 h of EVT reduced the likelihood of good outcomes at 3 months. The effects of these parameters on outcomes are more substantial amongst patients with successful reperfusion after EVT, suggesting that different BP control strategies should be employed according to reperfusion status. Click here to view the accompanying paper in this volume. [ABSTRACT FROM AUTHOR]

To establish the coating conditions for 57Co, non-radioactive Co ions are dissolved in an acid solution and electroplated on to a rhodium plate. The thermal diffusion of electroplated Co into a rhodium matrix was studied to apply a 57Co Mössbauer source. The procedure to form a Co deposited onto Rh foil was established using two different electroplating baths: the acid-based buffer (pH 3) containing boric acid, sodium chloride, and saccharin, and the alkaline-based buffer (pH 10) containing hydrazine hydrate and ammonium citrate. The influence of different annealing conditions was investigated. From the results, the best diffusion degree of electrodeposited Co onto the rhodium matrix was obtained in an annealing process performed at 1100°C for 3 h in vacuum over10-5 hPa. [ABSTRACT FROM AUTHOR]

Recent studies have focused on the relationship between nocturia and serum testosterone because testosterone is thought to be an important factor of prostate growth. However, it remains unclear whether altered serum concentrations of testosterone is associated with an increased risk of nocturia because patients who were taking diuretics or who had a large prostate, which may precipitate nocturia, were not excluded from most previous studies. We analyzed the clinical records of 596 non-benign prostatic enlargement ( BPE) male patients to explore the relationship between serum total testosterone and nocturia. All patients were evaluated using a serum prostate-specific antigen ( PSA) assay, measurement of serum total testosterone, transrectal ultrasonography, uroflowmetry, and a compilation of the International Prostate Symptom Score ( IPSS) and International Index of Erectile Function ( IIEF) questionnaires. Nocturia was defined as ≥2 nocturnal voiding episodes. The number of nocturia episodes was assessed using IPSS question 7. To evaluate the effect of serum testosterone on nocturia, multivariate regression analysis was performed including the covariates of age, IPSS, IIEF score, body mass index, PSA, prostate volume, and maximal urine flow rate. Based on multivariate linear analysis, serum testosterone level was not significantly associated with the severity of nocturia. However, with regard to the relationship between prevalence of nocturia and serum testosterone, prevalence of nocturia was significantly positively associated with age ( OR = 1.048, p = 0.005), total IPSS ( OR = 1.217, p < 0.001), and testosterone level ( OR = 1.150, p = 0.041). Therefore, in men without an enlarged prostate, testosterone may play an opposing role in the etiology of nocturia. [ABSTRACT FROM AUTHOR]

A series of SrTiMnO (0.05 ≤ x ≤ 0.3) was fabricated by the solid-state reaction method. We studied the structural and thermoelectric properties of SrTiMnO, with respect to the partial substitution of Ti for Sr. The sintered SrTiMnO crystallized in the hexagonal perovskite-type structure with a space group of P6/ mmc. For x ≤ 0.1, the partial substitution of Ti for Sr led to increases in the electrical conductivity and the absolute value of the Seebeck coefficient, thus enhancing the power factor. The highest power factor (2.5 × 10 WmK) was obtained for SrTiMnO at 800°C. The partial substitution of Ti for Sr in SrMnO led to a significant improvement in the thermoelectric properties. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

The CC chemokine eotaxin contributes to epithelium-induced inflammation in airway diseases such as asthma. Eupatilin (5,7-dihydroxy-3′,4′,6′-trimethoxyflavone), a bioactive component of Artemisia asiatica Nakai (Asteraceae), is reported to inhibit the adhesion of eosinophils to bronchial epithelial cells. However, little is known about the molecular mechanism of eupatilin-induced attenuation of bronchial epithelium-induced inflammation. In this study, we investigated the effect of eupatilin on expression of eotaxin-1 ( CCL11), a potent chemoattractant for eosinophils. Eupatilin significantly inhibited eotaxin expression in bronchial epithelial cells stimulated with TNF-α, while NF-κB and IκBα kinase ( IKK) activities declined concurrently. Eupatilin also inhibited mitogen-activated protein kinase ( MAPK) activity; however, all of these anti-inflammatory activities were reversed by MAPK overexpression. In contrast, eupatilin did not affect the signal transducer and activator of transcription 6 ( STAT6) signalling in bronchial epithelial cells stimulated with IL-4. Furthermore, eupatilin significantly attenuated TNF-α-induced eosinophil migration. These results suggest that the eupatilin inhibits the signalling of MAPK, IKK, NF-κB and eotaxin-1 in bronchial epithelial cells, leading to inhibition of eosinophil migration. [ABSTRACT FROM AUTHOR]

Background Few reports discuss the optimal management of patients diagnosed with tuberculosis ( TB) before scheduled stem cell transplantation ( SCT), who then proceed with transplantation. Methods We found 13 patients with TB before SCT (proven, n = 9; probable, n = 3; possible, n = 1) in the medical records of our institution. Results Most of the patients had pulmonary TB ( n = 8; disseminated, n = 2; extrapulmonary, n = 3). Eight of 9 patients with proven disease had SCT after at least 100 days of anti-tuberculous medication, ranging from 103 to 450 days. None of those patients suffered TB-related events after SCT. However, 1 patient with proven pulmonary TB who underwent SCT after only 40 days of anti-tuberculous therapy subsequently died of TB meningitis. Patients with possible and probable disease had their transplants after 6-176 days of anti-tuberculous medication, and all were alive at the time of analysis. The entire duration of anti-tuberculous medication was 12 months in most cases. With a follow-up duration ranging from 0.7 to 87.5 months, 4 patients died, but TB was the cause of death in only 1 case. Conclusion In conclusion, for proven cases of TB, SCT after >100 days of anti-tuberculous medication is probably feasible and safe, in terms of TB control, in patients with various hematologic diseases. [ABSTRACT FROM AUTHOR]

This study aimed to determine the effect of hardness change according to penetration depth in the laser fusing zone and observed the correlation of the microstructure as an Nd:YAG laser was irradiated to Ni-Cr alloy for dental use by setting the spot diameter size to various conditions. In all groups, the hardness depth profiles in the laser fusing zone and heat-affected zone (HAZ) had larger values than those of the base metal. In addition, the hardness values in places beyond the fusing zone and the HAZ were measured as being quantitatively lower. The observation result of the diffusion of the constituent elements and microstructure using field emission scanning electron microscopy, energydispersive spectroscopy, and electron probe microanalyzer showed that the fusing zone revealed a much finer dendritic form than the base metal due to the self-quenching effect after welding, while no change in constituent elements was found although some evaporation of the main elements was observed. In addition, Mo- and Si-combined intermetallic compounds were formed on the interdendritic area. Through this study, the laser fusing zone had better hardenability due to the intermetallic compound and grain refinement effect. [ABSTRACT FROM AUTHOR]

Background The aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis. Methods This study was a multicenter, randomized, parallel-controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active and sham acupuncture groups received acupuncture treatment three times per week for 4 weeks. In the sham group, minimal acupuncture at nonacupuncture points was used. The waitlist group did not receive any acupuncture treatment. Results Of the 238 participants, 97, 94, and 47 individuals were assigned to the active acupuncture, sham acupuncture, and waitlist group, respectively. After the treatment, the difference in the total nasal symptom score ( TNSS) was significantly reduced in the active acupuncture group compared with the sham acupuncture (difference: −1.03, 95% confidence interval [ CI]: −1.96, −0.09, P = 0.03) and waitlist (difference: −2.49, 95% CI: −3.68, −1.29, P < 0.0001). The active acupuncture group exhibited a significant change in the total non-nasal symptom score ( TNNSS) compared with the waitlist (difference: −0.78, 95% CI: −1.22, −0.34, P = 0.0002), but not the sham acupuncture group (difference; 0.15, 95% CI: −0.21, 0.5, P = 0.56). Both active and sham acupuncture treatments resulted in significant improvements in TNSS and TNNSS compared to baseline. Conclusion Active acupuncture showed a significantly greater effect on symptoms of allergic rhinitis than either sham acupuncture or no active treatment. The symptoms of allergic rhinitis decreased significantly after treatment in the both acupuncture and sham acupuncture groups. Acupuncture appears to be an effective and safe treatment for allergic rhinitis. [ABSTRACT FROM AUTHOR]

Background In allogeneic stem cell transplantation (allo- SCT), reduced-intensity conditioning ( RIC) is known for producing less regimen-related toxicity. However, whether or not RIC reduces the risk for infection and infection-related mortality ( IRM) remains controversial. Methods We retrospectively analyzed infectious episodes and IRMs after allo- SCTs by time period and by the intensity of the conditioning regimen ( RIC [ n = 81] vs. myeloablative conditioning, MAC [ n = 150]). Results The cumulative incidence of any kind of infection was lower in the RIC group through the entire period (72% vs. 87%; P = 0.007). The onset of infections was deferred in the RIC group as compared with the MAC group ( P = 0.012). Bacteremia occurred less frequently in the RIC group through the entire period (5% vs. 14%; P = 0.044). However, the incidences of cytomegalovirus reactivation and disease, herpes zoster, virus-associated hemorrhagic cystitis, and invasive fungal infection were not different between the two groups. Furthermore, there was no difference in relapse-free survival and IRM between the two conditioning regimens. Conclusion Careful monitoring and appropriate preventive/therapeutic strategies for infectious complications, comparable to those for allo- SCT recipients with MAC, should also be applied to those with RIC, especially after engraftment. [ABSTRACT FROM AUTHOR]

Backgrounds: Juxtacortical spots on fluid-attenuated inversion recovery (FLAIR) images can be frequently detected in patients with migraine. However, the origins of the cerebral lesions (including juxtacortical spots on FLAIR images) found in the previous studies are not known. We sought to investigate the association between juxtacortical spots on FLAIR images and right-to-left shunt (RLS) in migraine patients. Methods: Juxtacortical spots on FLAIR images were arbitrarily defined as small areas of hyperintensities in the juxtacortex and cortico-subcortical junction. The presence of RLS was examined by a transcranial Dopper (TCD) with the agitated saline test. The degree of RLS was categorized into four grades according to the number of microemboli: no shunt, <10 microbubbles (MB), >10 MB single spots pattern, and >10 MB shower/curtain pattern. We compared the results for migraine patients ( n = 49) with those for healthy controls ( n = 49). Results: Juxtacortical spots on FLAIR images occurred in 38/98 subjects; of them, 27/49 (55.1%) had migraines and 11/49 (22.2%) were healthy controls ( P = 0.002). The independent factors associated with juxtacortical spots on FLAIR images were female, migraine patients, and RLS by multivariate analysis. In migraine patients, RLS was independently associated with juxtacortical spots on FLAIR images. Conclusion: Our results suggest that juxtacortical spots on FLAIR images were frequently found in migraine patients and might be associated with the presence of RLS in those patients. Further studies are needed to assess whether juxtacortical spots have clinical implications in patients with migraine. [ABSTRACT FROM AUTHOR]

Electromagnetic (EM) characteristics and the shielding effectiveness (SE) of cement matrix materials fabricated with different contents of multi-walled carbon nanotubes (MWNTs) were investigated at a frequency range of 0.1 to 18 GHz in this study. To incorporate MWNTs in the cement matrix materials, MWNTs were mixed with a surfactant in the purified water and then sonicated to set bundled MWNTs apart prior to mixing with fiber-added mortar. The dispersion quality of MWNTs in water was analyzed by ultraviolet-visible near-infrared (UV-vis-NIR) absorption spectra, whereas the dispersion quality of MWNTs in the cement matrix was examined by observation of the fracture surface using a scanning electron microscope (SEM). EM wave SE measurement was conducted using a network analyzer with a coaxial transmission line. The most effective shielding performance in a comprehensive frequency range was attained with the incorporation of 1.5% of MWNTs with respect to the cement content in the matrix. The cement matrix materials displayed improved shielding of EM waves within the X-band, although degradation of EM wave SE resulting from air voids in the materials was observed. In SEM observations, most of the MWNTs were separated and embedded in the cement hydration product. As a result, it can be concluded that the cement matrix materials with MWNTs have noteworthy potential as candidate EM wave-shielding materials. [ABSTRACT FROM AUTHOR]

Background and purpose: Because hemorrhagic transformation (HT) is associated with morbidity and mortality, we need a better understanding of the factors that predict HT after ischaemic stroke. HT is a well-known factor that limits the use of thrombolytics and it negates the effect of treatment. This study investigated whether a high serum ferritin level is associated with HT in acute ischaemic stroke. Methods: Seven hundred and fifty-two consecutive patients with acute ischaemic stroke within 24 h after a vascular event were enrolled. HT was diagnosed using magnetic resonance imaging (MRI) or computed tomography (CT) and the HT was classified into hemorrhagic infarction (HI) type 1, 2 and parenchymal hematoma (PH) type 1, 2. HT was also classified into no HT, asymptomatic HT, minor symptomatic HT (sHT), and major sHT. Results: Computed tomography or MR showed HT in 90 patients (HI in 58 and PH in 32; asymptomatic in 53, minor symptomatic in 23 and major symptomatic in 14). The ferritin levels were higher in the patients who developed HT, PH and sHT. After adjustment for confounding variables, multivariate analysis showed that a high ferritin level remained an independent predictor of HT in the patients with acute ischaemic stroke ( P < 0.001). Serum ferritin levels higher than 171.8 ng/ml were independently associated with sHT. Conclusions: This study suggests that a high ferritin level is an important predictor of HT, PH, and sHT in patients with acute ischaemic stroke. Lowering the ferritin level with iron-modifying agents or using free radical scavengers could be helpful to prevent HT in ischaemic stroke. [ABSTRACT FROM AUTHOR]

Background and purpose: The presence of collateral middle cerebral artery (MCA) flow via the primary collateral pathway is thought to protect against the progression of cerebral ischaemia. However, there have been few reports on early clinical outcomes according to the presence of collateral MCA flow in acute ischaemic stroke (AIS) with internal carotid artery (ICA) occlusion. Therefore, we sought to investigate the early clinical outcomes and lesion patterns according to the presence of collateral MCA flows in AIS with ICA occlusion. Methods: This is a retrospective study of patients with AIS with ICA occlusion consecutively admitted to our stroke center between October 2008 and March 2010. Patients were included if they were admitted within 12 h of symptom onset with AIS and symptomatic ICA occlusion. Collateral MCA flow was defined as the presence of MCA signals from proximal M1 to distal MCA branches ipsilateral to the ICA occlusion by magnetic resonance angiography. Early neurological deterioration (END) was defined as a 4-point increase in the National Institutes of Health Stroke Scale (NIHSS) score and persistent neurological deterioration for at least 24 h or newly developed neurological symptoms within 7 days. Results: Sixty-five patients (42 men, 23 women) were finally included. Initial NIHSS scores were significantly lower, and favorable outcomes at 3 months were better in patients with collateral MCA flow than in those without ( P < 0.001). Initial lesion patterns were different according to the collateral MCA flow. However, patients with mild AIS might more frequently deteriorate than those with moderate to severe AIS. Conclusions: In our study, collateral MCA flow reduced initial stroke severity and was associated with favorable outcomes at 3 months but did not seem to protect against END in mild AIS patients with ICA occlusion. Therefore, the results of this study suggest that mild AIS patients with ICA occlusion should be carefully managed because their conditions may deteriorate. [ABSTRACT FROM AUTHOR]

DA-6034 is a synthetic derivative of eupatilin, a flavonoid with anti-inflammatory effects. The aim of this study was to investigate the effects of DA-6034 on the interactions between IκB kinase (IKK) and heat shock protein 90 (Hsp90), and activation of the nuclear factor-kappaB (NF-κB) signalling pathway in human gastric epithelial cells infected with Helicobacter pylori. MKN-45 gastric epithelial cell line was treated with DA-6034 and H. pylori. DA-6034 significantly inhibited NF-κB activation and upregulated the expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 in MKN-45 cells infected with H. pylori. However, DA-6034 did not influence activator protein-1 DNA binding activity in H. pylori-infected gastric epithelial cells. Pretreatment with DA-6034 attenuated the H. pylori-induced increase in IKK activity, and Hsp90 was associated with IKK-α and IKK-γ in MKN-45 cells. Treatment with DA-6034 dissociated the Hsp90 and IKK-γ complex in H. pylori-infected cells, leading to the inhibition of IL-8 expression. These results suggest that the eupatilin derivative 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone has anti-inflammatory activity in gastric epithelial cells infected with H. pylori through the promotion of the dissociation of the IKK-γ-Hsp90 complex and suppression of NF-κB signalling. [ABSTRACT FROM AUTHOR]

Clinical and radiological features of patients with unclear-onset stroke do not differ significantly from those with known-onset stroke. There is a lack of evidence for the safety and efficacy of thrombolysis in patients with unclear-onset stroke. We sought to provide supportive data on the safety and efficiency of thrombolysis in patients with unclear-onset stroke. We retrospectively identified patients with unclear-onset stroke (<3 h of first found abnormal time) from our stroke registry. We performed following protocols for thrombolysis in patients with unclear-onset stroke; initial conventional CT-based intravenous thrombolysis (IVT), repeat MRI during IVT, and then decision to maintain IVT or to perform combined intra-arterial thrombolysis. In addition, we compared clinical outcomes and safety between thrombolyzed and non-thrombolyzed patients. A total of 78 patients with unclear-onset stroke were included. Twenty-nine patients underwent thrombolysis. Thrombolysis (OR, 6.842; 95% CI, 1.950-24.004; P = 0.003) and baseline NIHSS (OR, 0.769; 95% CI, 0.645-0.917; P = 0.003) were associated with favorable outcomes at 3 months in multivariate logistic regression analysis. The frequency of hemorrhagic transformation and symptomatic ICH was not significantly different between the thrombolyzed and non-thrombolyzed patients (34.4% vs. 40.7% and 10.3% vs. 8.2%, respectively). The results of this study suggest that thrombolysis in unclear-onset stroke could be independently associated with favorable outcomes at 3 months and that thrombolysis based on repeat imaging appears to be safely applied to patients with unclear-onset stroke. Click to view the accompanying paper in this issue. [ABSTRACT FROM AUTHOR]

An international intercomparison involving eight national metrology institutes (NMIs) was conducted to establish their current measurement capabilities for determining five selected congeners from the brominated flame retardant classes polybrominated diphenyl ethers and polybrominated biphenyls. A candidate reference material consisting of polypropylene fortified with technical mixtures of penta-, octa- and decabromo diphenyl ether and decabromo biphenyl, which was thoroughly assessed for material homogeneity and stability, was used as study material. The analytical procedures applied by the participants differed with regard to sample pre-treatment, extraction, clean-up, employed calibrants and type of calibration procedure as well as regarding analytical methods used for separation, identification and quantification of the flame retardant congeners (gas chromatography coupled to an electron capture detector (GC-ECD), gas chromatography-mass spectrometry in the electron ionisation mode (GC-EI-MS), gas chromatography-mass spectrometry in the electron capture negative ionisation mode (GC-ECNI-MS), and liquid chromatography-inductive coupled plasma-mass spectrometry (LC-ICP-MS)). The laboratory means agreed well with relative standard deviations of the mean of means of 1.9%, 4.8%, 5.5% and 5.4% for brominated diphenyl ether (BDE) 47, 183 and 209 and for the brominated biphenyl (BB) congener 209, respectively. For BDE 206, a relative standard deviation of 28.5% was obtained. For all five congeners, within-laboratory relative standard deviations of six measurements obtained under intermediate precision conditions were between 1% and 10%, and reported expanded measurements uncertainties typically ranged from 4% to 10% (8% to 14% for BDE 206). Furthermore, the results are in good agreement with those obtained in the characterization exercise for determining certified values for the flame retardant congeners in the same material. The results demonstrate the state-of-the-art measurement capabilities of NMIs for quantifying representative BDE congeners and BB 209 in a polymer. The outcome of this intercomparison (pilot study) in conjunction with possible improvements for employing exclusively calibrants with thoroughly assessed purity suggests that a key comparison aiming at underpinning calibration and measurement capability (CMC) claims of NMIs can be conducted. [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Objectives. To evaluate the incidence of infectious complications after receiving alemtuzumab as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in Korean patients. Methods. From November 2004 to January 2006, 12 patients who received alemtuzumab-based conditioning regimens for allogeneic HSCT were evaluated retrospectively until death or until the end of the follow-up in July 2007; they were compared with 18 patients who received rabbit anti-thymocyte globulin (ATG)-containing conditioning regimens from January 2002 to January 2006. Results. Post-engraftment infections occurred more frequently in the alemtuzumab recipients than in the ATG recipients; the mean number of infections, excluding cytomegalovirus (CMV) infections, per patient during the follow-up period was 2.6±1.4 vs. 1.0±0.8 ( P=0.003), respectively. Although there was no statistical difference in the cumulative incidence of CMV infection between the 2 groups (91.7% vs. 55.6%, P=0.381), the alemtuzumab recipients had a higher incidence of CMV diseases (41.6% vs. 0%, P=0.0006) and a higher recurrence rate of CMV infection (90.0% vs. 27.3%, P=0.008) than did the ATG recipients, irrespective of the dose of alemtuzumab. Hemorrhagic cystitis (HC) (66.7% vs. 16.7%, P=0.009) and BK virus-associated HC (41.7% vs. 5.6%, P=0.026) developed more frequently in the alemtuzumab recipients. The all-cause mortality rate was not significantly different between the alemtuzumab and the ATG recipients (75% vs. 55.6%, P=0.28). Conclusion. Alemtuzumab recipients had a high incidence of CMV disease as well as BK virus-associated HC compared with the ATG recipients. The dose of alemtuzumab should be tailored to patients' risk; in addition, the implementation of the appropriate prophylaxis for CMV and early detection strategies for BK virus are recommended. [ABSTRACT FROM AUTHOR]

The hypoglossal artery arises as a branch of the internal carotid artery and traverses the hypoglossal canal. However, the hypoglossal artery arising from the external carotid artery (ECA) and connecting directly with the posterior inferior cerebellar artery (PICA), instead of the basilar artery or the vertebral artery, is very rare. We present a case of an uncommon variant of the hypoglossal artery arising from the ECA that connected directly with the PICA. [ABSTRACT FROM AUTHOR]

This article proposes a new hybrid active mount featuring piezostacks and rubber element that can provide high performance in vibration control. After describing the configuration and operating principle of the proposed mount, appropriate rubber element and piezostack are designed and manufactured. Subsequently, dynamic characteristics of the piezostacks and the rubber element are experimentally identified. A two-degree-of-freedom control system, in which the hybrid active mount is installed with a supported mass of 100 kg, is then constructed for evaluating vibration control performance. To attenuate actively the vibration transmitted from the base excitation, a robust sliding mode controller is formulated by considering parameter uncertainties. The controller is then experimentally realized and vibration control performances of the proposed mount system are evaluated in both time and frequency domains. [ABSTRACT FROM AUTHOR]

Purpose: Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. Methods: Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ therapy at 200 mg/day after loading doses. NONMEM (Version. 5·1·1) was used to estimate population PK parameters. Results: Forty-two patients were enrolled in the study. Mean population CL and V of IV-ITZ were 10 L/h and 1050 L, respectively. Body weight was the only contributing covariate of CL. The median simulated trough concentration of ITZ after 10 days was predicted to be about 700 ng/mL. Conclusions: In this study, we explored the population PK profile of ITZ given in IV formulation. We found that the current dosage regimen of IV-ITZ (200 mg/day) was appropriate to obtain therapeutic trough concentrations for neutropenic patients in Korea. [ABSTRACT FROM AUTHOR]

The present work performs numerical optimization for design of blade stacking line for an axial flow fan with response surface method using three-dimensional Navier–Stokes analysis, and evaluates the effects of sweep and lean on the performance of the fan blade. Reynolds-averaged Navier–Stokes equations are discretized with finite-volume approximations using unstructured grids. Four geometric variables concerning spanwise distributions of sweep and lean of blade stacking line are chosen as design variables to find maximum efficiency. The computational results show good agreements with experimental data. The total efficiency is successfully increased in comparison with the reference fan by optimizing three-dimensional stacking line with sweep and lean. Coupling of sweep and lean also improves off-design performance of the blade remarkably. [ABSTRACT FROM AUTHOR]

This study examined whether manual acupuncture at the Siguan points (bilateral points LI4 and LR3) affects intestinal motility in healthy human subjects. Twenty healthy male subjects were randomly assigned either to real acupuncture (RA) at Siguan points or sham acupuncture (SA) groups in a crossover manner. All subjects underwent two experimental sessions; the RA group in the first session was treated with SA in the second session after a 2-week washout period, and vice versa. Each subject took 20 radio-markers and was treated with acupuncture 0, 12, 24, and 36 hours after radio-marker intake. Radiographs were taken at 6, 12.5, 24.5, and 48 hours, and the effect of acupuncture on intestinal motility was evaluated based on the distribution of the radio-markers in the ileum, ascending colon, transverse colon, descending colon, sigmoid/ rectum, and outside the body. Defecating habit was monitored during the trial, and complete blood counts were checked before and after the two acupuncture sessions. The RA and SA results showed extremely similar distributions of the radio-markers in these five regions of the alimentary canal and outside the body in radiographs taken at four different times, verifying that there was no effect of manual acupuncture at the Siguan points on intestinal motility, at least in healthy human subjects. [ABSTRACT FROM AUTHOR]

The KSTAR Central Solenoid Model Coils (CSMC), which are in the form of split coils with same dimension, have been tested. The CSMC were successfully charged up to 20 kA and down to zero with different ramp rates. Various pulse waveforms were applied to the CSMC to analyse the AC-loss characteristics of the coils. The measurement method was a gas-flow calorimetry. In this work, two types of waveforms, the DC-biased sinusoidal wave (Idc = 2, 4 kA; ΔIac = 1 kA; ƒ = 0.08 ∼ 0.67 Hz) and a single triangular pulse (Imax = 6 ∼ 10 kA; dI/dt = 0.5 ∼ 2 kA/s), are selected and analysed. From the measured data at the one outlet where helium channel 3 and 4 are merged, the AC loss parameters, related with the hysteresis loss and the coupling loss, are calculated. The B-field strength differs depending on the position within the cooling channels. The spatial field variation and the ramp rate were 0.048∼ 1.9T and 8.1∼ 71 mT/s for the DC-biased sinusoidal waves, while 0.29∼ 4.3 T and 0.024∼ 0.86 T/s for the triangular pulses. The measured AC losses are compared with estimated values and the behavior agrees well. The coupling time constant (nτ) varies with the field strength. In case of the triangular pulses, nτ increases by increasing the field amplitude and the maximum value of nτ is 41 ms with Imax = 10 kA. [ABSTRACT FROM AUTHOR]

We report on a severe, verrucous facial mycosis and sinusitis in a 12-year-old Libyan girl. Her disease started with verrucous, hyperkeratotic plaques and subcutaneous violet nodules of unknown origin on her face and upper extremities. Despite topical antimycotic therapy she needed in-hospital treatment because of severely progressive tumorous cutaneous and nasal lesions. Microscopic examination of scale samples taken from the upper extremities and the face revealed brown, thick-walled fungal elements. Under the assumption of a chromoblastomycosis, an oral treatment with itraconazole and fluorocytosin was initiated, with significant improvement of the lesions. The aetiological agent was identified as Phialophora verrucosa. [ABSTRACT FROM AUTHOR]

Summary:We reviewed 242 allogeneic hematopoietic stem cell transplantation (HSCT) recipients retrospectively over a 2-year period (January 1998-December 1999) in order to analyze the characteristics and assess the outcomes of infectious complications in patients after HSCT in Korea. Bacteria were the major pathogens before engraftment, and viral and fungal infections predominated during the post-engraftment period. Varicella zoster virus was the most common viral pathogen after engraftment. Cytomegalovirus disease occurred mainly in the late-recovery phase. The frequency of mold infection was higher than that of yeast. There was a relatively high incidence of tuberculosis (3.0%) and Pneumocystis carinii pneumonia (6.5%). One case of death by measles confirmed by autopsy was also noted. Overall, cumulative mortality was 43%(104/242), and 59.6%of these deaths (62/104) were infection-related. Allogeneic HSCT recipents from unrelated donors were prone to infectious complication and higher mortality than those from matched sibling (17/39 (43.6%) vs 45/203 (22.2%), respectively; P<0.01; odd ratio 2.5; 95%confidence interval 1.2-5.1). As infection was the main post-HSCT complication in our data, more attention should be given to the management of infections in HSCT recipients.Bone Marrow Transplantation (2004) 34, 497-504. doi:10.1038/sj.bmt.1704636 Published online 2 August 2004 [ABSTRACT FROM AUTHOR]

A long-term experiment was conducted in sea cages to compare three experimental extruded pellet (EP) diets with a raw fish moist pellet (MP) diet for Korean rockfish, Sebastes schlegeli (Hilgendorf). White fishmeal (WFM), soybean meal (SM) and fishmeal analogue (BAIFA-M™)-based experimental EP diets were formulated to be isonitrogenous and isocaloric with 50% crude protein (CP) with available energy of 16.7 kJ g[sup -1] diet. An MP diet made of 80% frozen horse mackerel + 20% commercial binder meal was also included in the experiment. The proportions of the major protein ingredients in three experimental EP diets were as follows: WFM diet, 100% WFM; SM diet, 70% WFM + 30% SM; BAIFA-M™ diet, 70% WFM + 30% BAIFA-M™. The experiment was divided into three periods according to fish size: period I, initial weight of 20.2 ± 3.6 g (mean ± SD); period II, initial weight of 57.6 ± 4.7 g (mean ± SD); period III, initial weight of 96.3 ± 6.9 g (mean ± SD). There were no significant differences in weight gain, feed efficiency ratio, thermal-unit growth coefficient, specific growth rate, haemoglobin, or haematocrit among fish that were fed the four diets during all three periods. However, fish that were fed the MP diet had a lower survival rate than the fish that were fed the other three EP diets for all periods. These results strongly suggest that EP diets could be developed to replace MP diet for the grow-out stage of production of Korean rockfish without adverse effects on growth performance. [ABSTRACT FROM AUTHOR]

Frasier syndrome is a rare human developmental disorder classically affecting 46,XY females and leading to male pseudohermaphroditism and chronic renal failure. We describe a family with both 46,XX and 46,XY females affected by the syndrome due to WT1 splice site mutations. The diagnosis of Frasier syndrome in 1 of the children led to the discovery of the syndrome in 2 other siblings, of whom 1 is asymptomatic. Since the mutation was not found in either parents, gonadal mosaicism was suggested. The implication of family screening for WT1 gene mutation in asymptomatic members is also discussed.Copyright © 2002 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

A 6-week feeding trial was conducted to determine the apparent protein and phosphorus digestibilities in order to evaluate five different dietary protein sources in juvenile Korean rockfish, Sebastes schlegeli. Five diets containing fish meal analog (BAIFA-M[sup TM]), white fish meal (WFM), rockfish muscle (RM), soybean meal (SM) or corn gluten meal (CGM) were prepared by mixing a basal diet (BD) with one of five test ingredients at the ratio of 7:3. As a reference diet, BD contained three different protein sources, such as casein, gelatin and rockfish muscle. Fish averaging 3.1 ± 0.03 g (mean ± SD) were distributed to each aquarium as a group of 20 fish reared in the recirculating system. Fish of triplicate groups were fed one of six experimental diets (BD + five test diets). Apparent digestibilities of dry matter, protein and phosphorus of six diets were determined by the chromic oxide (Cr[sub 2]O[sub 3]) method. After 6 weeks of the feeding trial, apparent protein digestibilities of RM, WFM, CGM, SM and BAIFA-M[sup TM] were 92.6%, 87.5%, 79.1%, 76.2% and 70.6%. Apparent phosphorus digestibilities of RM, BAIFA-M[sup TM], WFM, CGM and SM were 77.5%, 66.9%, 59.5%, 22.2% and 12.6%. The protein efficiency ratio (PER) ranked with RM > WFM, BD > BAIFA-M[sup TM], CGM and SM (P < 0.05). PER was positively correlated with apparent protein digestibility (r[sup 2] = 0.82, P < 0.05). [ABSTRACT FROM AUTHOR]

Two experiments were conducted to compare the patterns of plasma free amino acid concentrations after force-feeding in rainbow trout Oncorhynchus mykiss (Walbaum) with and without dorsal aorta cannulation. In the first experiment, 35 rainbow trout averaging 504 ± 7.8 g (mean ± SD) were divided into seven groups of five fish each. After 48 h starvation, a group of fish was anaesthetized and blood samples were taken at one of the following time periods: 0, 4, 8, 12, 24, 36 and 48 h after feeding. In the second experiment, five dorsal aorta cannulated rainbow trout averaging 511 ± 6.2 g (mean ± SD) were kept in a cage. After 48 h starvation, the fish were anaesthetized and blood samples were taken from the same fish at 0, 4, 8, 12, 24, 36 and 48 h after feeding. In the first experiment, the concentration of all plasma free amino acids except histidine and glycine peaked at 4 h and returned to the basal level 24 h after feeding. In the second experiment, the concentration of all plasma free amino acids except isoleucine, leucine, phenylalanine and tryptophan also peaked at 4 h and returned to the basal level 24 h after feeding. These results showed that the pattern of plasma free amino acid concentrations from fish with and without dorsal aorta cannulation were similar. [ABSTRACT FROM AUTHOR]

Examines the potentials of focusing cold neutron beams by biconcave lenses in extending the lower limit of scattering vector Q in small-angle neutron scattering instruments. Feasibility of the focusing technique; Measurement of focused beam profile; Comparison of the performance of the focusing lens configuration with pinhole collamination.

A novel type of bioreactor was successfully developed for the production of taxol and its precursors by culturing cells of Taxus cuspidata (Japanese yew) on a pilot-scale. Rapidly growing cell lines were selected from callus cultures derived from immature embryos of yew. The cells were inoculated in 20-l capacity bioreactors of different types to test the growth performance. The models of small-scale bioreactors incorporated in this study included a balloon-type bubble bioreactor (BTBB), a bubble-column bioreactor (BCB), a BCB with a split-plate internal loop, a BCB with a concentric draught-tube internal loop, a BCB with a fluidized bed bioreactor, and two different models of stirred tank reactors. Among the reactors, BTBB appeared to be the most efficient in promoting cell growth. The doubling time of cell growth in BTBB was 12 days with a 30% inoculation cell density. The optimum time for medium replacement or feeding was 12–15 days after inoculation as determined by monitoring both the levels of sugars and medium conductivity. When yew tree cells were grown in different sizes (100–500-l) of BTBBs, more than 70% cell viability was recorded at the time of harvest. The growth pattern of the cells in the pilot-scale BTBB appeared to be the same as that of cells in the 20-l bioreactors. Approximately 3 mg/l of taxol and 74 mg/l total taxanes were obtained after 27 days of culture. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented about calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation.

Presents a letter to the editor in response to the article "T-Cell Lymphoproliferative Disorder Following a Full Haplotype-Mismatched Haematopoietic Stem Cell Transplant in a Patient With Acute Myeloid Leukaemia," published in previous issue.

A letter to the editor is presented which describes the association of antiepileptic drug Valproic acid (VPA) to clinical alveolar hemorrhage.

An aluminium-based packaging platform with microreflector and electrical via for an interconnection electrode is first proposed for a package component of a light-emitting diode (LED). The electrode-guided interconnection with 180 µm thickness has been successfully fabricated by using the selectively anodising process, and not by either the plating or the solder paste technique. The reflector was formed during the isotropic etching process. By mainly a two-step chemical process, the LED packaging platform integrated microreflector and electrical via in one body was developed in a low-cost process. [ABSTRACT FROM AUTHOR]

Presents a medical case of bacteremic cellulitis caused by non-O1, non-o139 Vibrio cholerae in a patient following hematopoietic stem cell transplantation. Profile of the patient; Medical proceedure administered.

The article reports on the summer school on cold neutrons for Korean neutron beam users, co-hosted by the Korea Atomic Energy Research Institute (KAERI) and the Advanced Research Center for Nuclear Excellence (ARCNEX), held in Daejeon, Korea on July 16-18, 2012.