1. One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.
- Author
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Şenışık, A. M., İçhedef, Ç., Kılçar, A. Y., Uçar, E., Arı, K., Göksoy, D., Parlak, Y., Sayıt Bilgin, Bedriye Elvan, and Teksöz, S.
- Subjects
GLYCINE ,RADIOLABELING ,CHEMOSELECTIVITY ,POSITRON emission tomography ,RADIOPHARMACEUTICALS - Abstract
This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [
18 F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18 F]FDG solution. The radiolabeled product ([18 F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for18 F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18 F]FDG tagged GlyGly in vivo. [ABSTRACT FROM AUTHOR]- Published
- 2018
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