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One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.
One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.
- Source :
- Journal of Radioanalytical & Nuclear Chemistry; May2018, Vol. 316 Issue 2, p457-463, 7p, 1 Black and White Photograph, 3 Diagrams, 3 Graphs
- Publication Year :
- 2018
-
Abstract
- This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [<superscript>18</superscript>F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [<superscript>18</superscript>F]FDG solution. The radiolabeled product ([<superscript>18</superscript>F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for <superscript>18</superscript>F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [<superscript>18</superscript>F]FDG tagged GlyGly in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 316
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 129323271
- Full Text :
- https://doi.org/10.1007/s10967-018-5772-x