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One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.

One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study.

Authors :
Şenışık, A. M.
İçhedef, Ç.
Kılçar, A. Y.
Uçar, E.
Arı, K.
Göksoy, D.
Parlak, Y.
Sayıt Bilgin, Bedriye Elvan
Teksöz, S.
Source :
Journal of Radioanalytical & Nuclear Chemistry; May2018, Vol. 316 Issue 2, p457-463, 7p, 1 Black and White Photograph, 3 Diagrams, 3 Graphs
Publication Year :
2018

Abstract

This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [<superscript>18</superscript>F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [<superscript>18</superscript>F]FDG solution. The radiolabeled product ([<superscript>18</superscript>F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for <superscript>18</superscript>F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [<superscript>18</superscript>F]FDG tagged GlyGly in vivo. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02365731
Volume :
316
Issue :
2
Database :
Complementary Index
Journal :
Journal of Radioanalytical & Nuclear Chemistry
Publication Type :
Academic Journal
Accession number :
129323271
Full Text :
https://doi.org/10.1007/s10967-018-5772-x