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The Zika virus (ZIKV) is a serious global public health crisis. A major control challenge is its multiple transmission modes. This paper aims to simulate the transmission patterns of ZIKV using a dynamic process-based epidemiological model written in ordinary differential equations, which incorporates the human-to-mosquito infection by bites and sewage, mosquito-to-human infection by bites, and human-to-human infection by sex. Mathematical analyses are carried out to calculate the basic reproduction number and backward bifurcation, and prove the existence and stability of the equilibria. The model is validated with infection data by applying it to the 2015–2016 ZIKV epidemic in Brazil. The results indicate that the reproduction number is estimated to be 2.13, in which the contributions by mosquito bite, sex and sewage account for 85.7%, 3.5% and 10.8%, respectively. This number and the morbidity rate are most sensitive to parameters related to mosquito ecology, rather than asymptomatic or human-to-human transmission. Multiple transmission routes and suitable temperature exacerbate ZIKV infection in Brazil, and the vast majority of human infection cases were prevented by the intervention implemented. These findings may provide new insights to improve the risk assessment of ZIKV infection. [ABSTRACT FROM AUTHOR]

Discrete Element Method (DEM) has been successfully utilized to model rock behavior based on particle flow code (PFC), which is extensively employed in solving various problems related to rock engineering and geomechanics. Therefore, a convenient method for selecting appropriate microparameters of PFC for model generation is necessary. The present study aims to develop a novel approach that calculates proper micro-strength parameters for the contact bond model (CBM). Firstly, based on Plackett–Burman (PB) design, qualitative research is conducted and it is found that the main factors that influence the Brazilian tensile strength is microscopic tensile strength. We analyzed the stress conditions of a Brazilian disc's vertical diameter using both continuum models and DEM. From this analysis, we establish a theoretical relationship between rock tensile strength and micro-strength parameters. Subsequently, a large number of numerical Brazilian tests were conducted to obtain the statistical relationship between the geometric parameters of balls, micro-strength parameters and the Brazilian tension strength. The results of the numerical simulation were then used to refine the theoretical equation mentioned above, resulting in a modified equation for rock tensile strength and micro-strength parameters. Finally, after verification, we confirm the feasibility of the method in this paper. [ABSTRACT FROM AUTHOR]

The Zika virus (ZIKV) is a serious global public health crisis. A major control challenge is its multiple transmission modes. This paper aims to simulate the transmission patterns of ZIKV using a dynamic process-based epidemiological model written in ordinary differential equations, which incorporates the human-to-mosquito infection by bites and sewage, mosquito-to-human infection by bites, and human-to-human infection by sex. Mathematical analyses are carried out to calculate the basic reproduction number and backward bifurcation, and prove the existence and stability of the equilibria. The model is validated with infection data by applying it to the 2015–2016 ZIKV epidemic in Brazil. The results indicate that the reproduction number is estimated to be 2.13, in which the contributions by mosquito bite, sex and sewage account for 85.7%, 3.5% and 10.8%, respectively. This number and the morbidity rate are most sensitive to parameters related to mosquito ecology, rather than asymptomatic or human-to-human transmission. Multiple transmission routes and suitable temperature exacerbate ZIKV infection in Brazil, and the vast majority of human infection cases were prevented by the intervention implemented. These findings may provide new insights to improve the risk assessment of ZIKV infection. [ABSTRACT FROM AUTHOR]

Open water transposition channels in hot and arid regions, like those in the São Francisco River Integration Project (PISF) in Brazil, suffer significant water losses through evaporation. This paper proposes covering these channels with photovoltaic (PV) panels to reduce evaporation while simultaneously generating clean energy. The research aims to quantify water savings and energy generation potential across all channel lengths and assess whether the generated solar power can substitute grid electricity for powering the transposition pumps during peak hours, thereby enhancing energy efficiency. This study analyzed the state-of-the-art of PV generation and calculated their solar potential. Identified the specific characteristics of PISF channels and watercourses considering the regional geography, meteorology, irradiation, and social peculiarities. And, finally, assessed the feasibility of covering the watercourses with solar panels. The results reveal that covering all current PISF channels with PV panels could save up to 25,000 cubic meters of water per day, significantly contributing to water security and improving the quality of life for the local population. Additionally, the project could generate 1200 gigawatt-hours of electricity annually, meeting the energy demands of the transposition pumps during peak hours and promoting energy efficiency within the project. This research paves the way for utilizing PV technology to address water scarcity challenges and enhance the sustainability of water infrastructure projects in arid regions worldwide. [ABSTRACT FROM AUTHOR]

The effects of the COVID-19 pandemic on comprehensive maternal deaths in Brazil have not been fully explored. Using publicly available data from the Brazilian Mortality Information (SIM) and Information System on Live Births (SINASC) databases, we used two complementary forecasting models to predict estimates of maternal mortality ratios using maternal deaths (MMR) and comprehensive maternal deaths (MMRc) in the years 2020 and 2021 based on data from 2008 to 2019. We calculated national and regional standardized mortality ratio estimates for maternal deaths (SMR) and comprehensive maternal deaths (SMRc) for 2020 and 2021. The observed MMRc in 2021 was more than double the predicted MMRc based on the Holt-Winters and autoregressive integrated moving average models (127.12 versus 60.89 and 59.12 per 100,000 live births, respectively). We found persisting sub-national variation in comprehensive maternal mortality: SMRc ranged from 1.74 (95% confidence interval [CI] 1.64, 1.86) in the Northeast to 2.70 (95% CI 2.45, 2.96) in the South in 2021. The observed national estimates for comprehensive maternal deaths in 2021 were the highest in Brazil in the past three decades. Increased resources for prenatal care, maternal health, and postpartum care may be needed to reverse the national trend in comprehensive maternal deaths. [ABSTRACT FROM AUTHOR]

The effects of the COVID-19 pandemic on comprehensive maternal deaths in Brazil have not been fully explored. Using publicly available data from the Brazilian Mortality Information (SIM) and Information System on Live Births (SINASC) databases, we used two complementary forecasting models to predict estimates of maternal mortality ratios using maternal deaths (MMR) and comprehensive maternal deaths (MMRc) in the years 2020 and 2021 based on data from 2008 to 2019. We calculated national and regional standardized mortality ratio estimates for maternal deaths (SMR) and comprehensive maternal deaths (SMRc) for 2020 and 2021. The observed MMRc in 2021 was more than double the predicted MMRc based on the Holt-Winters and autoregressive integrated moving average models (127.12 versus 60.89 and 59.12 per 100,000 live births, respectively). We found persisting sub-national variation in comprehensive maternal mortality: SMRc ranged from 1.74 (95% confidence interval [CI] 1.64, 1.86) in the Northeast to 2.70 (95% CI 2.45, 2.96) in the South in 2021. The observed national estimates for comprehensive maternal deaths in 2021 were the highest in Brazil in the past three decades. Increased resources for prenatal care, maternal health, and postpartum care may be needed to reverse the national trend in comprehensive maternal deaths. [ABSTRACT FROM AUTHOR]

Countries have pledged to different national and international environmental agreements, most prominently the climate change mitigation targets of the Paris Agreement. Accounting for carbon stocks and flows (fluxes) is essential for countries that have recently adopted the United Nations System of Environmental-Economic Accounting - ecosystem accounting framework (UNSEEA) as a global statistical standard. In this paper, we analyze how spatial carbon fluxes can be used in support of the UNSEEA carbon accounts in five case countries with available in-situ data. Using global multi-date biomass map products and other remotely sensed data, we mapped the 2010–2018 carbon fluxes in Brazil, the Netherlands, the Philippines, Sweden and the USA using National Forest Inventory (NFI) and local biomass maps from airborne LiDAR as reference data. We identified areas that are unsupported by the reference data within environmental feature space (6–47% of vegetated country area); cross-validated an ensemble machine learning (RMSE=9–39 Mg C ha - 1 and R 2 =0.16–0.71) used to map carbon fluxes with prediction intervals; and assessed spatially correlated residuals (<5 km) before aggregating carbon fluxes from 1-ha pixels to UNSEEA forest classes. The resulting carbon accounting tables revealed the net carbon sequestration in natural broadleaved forests. Both in plantations and in other woody vegetation ecosystems, emissions exceeded sequestration. Overall, our estimates align with FAO-Forest Resource Assessment and national studies with the largest deviations in Brazil and USA. These two countries used highly clustered reference data, where clustering caused uncertainty given the need to extrapolate to under-sampled areas. We finally provide recommendations to mitigate the effect of under-sampling and to better account for the uncertainties once carbon stocks and flows need to be aggregated in relatively smaller countries. These actions are timely given the global initiatives that aim to upscale UNSEEA carbon accounting. [ABSTRACT FROM AUTHOR]

We aimed to analyze the seasonal acclimatization process of Nelore and Canchim cattle raised on two production systems (non-shaded, NS, and integrated crop-livestock-forest, ICLF), based on the dynamics of the morphological and functional attributes of the hair coat and skin during winter and summer. The study was conducted in Brazil, in a low-altitude tropical climate region. A completely randomized 2 × 2 factorial design was adopted as follows: two production systems (NS and ICLF), two breeds (Nelore and Canchim) in a longitudinal structure, with measurements repeated over time through two stations (winter and summer). The experimental animals consisted of 32 Nelore (Bos indicus) and 32 Canchim (5/8 Bos taurus × 3/8 Bos indicus) bulls. The animals were equally distributed between two intensive rotational grazing systems. In both breeds, the hair coat was significantly thicker in winter but longer in summer, which increased epidermal protection. The Nelore bulls had shorter, wider, and thicker hairs, which are attributes that promote heat loss via conduction. The Canchim bulls showed significantly lower hair density and higher epithelium distance to sweat glands, which resulted in higher core temperature and respiratory rate. In turn, Nelore bulls had higher serum concentrations of triiodothyronine and lower serum concentrations of cortisol. However, Canchim bulls more frequently and intensely activated their thermoregulatory system and markedly adjusted their hair coat and hair features to reduce heat gain, especially in summer. Therefore, the anatomical plasticity and functional integumentary characteristics of Nelore and Canchim bulls reflect their acclimatization to tropical conditions. [ABSTRACT FROM AUTHOR]

Ocular syphilis is a re-emerging inflammatory eye disease with a clear gender imbalance, disproportionately affecting men. We investigated the impact of gender on the presentation, management practices and clinical outcomes of this condition. Data generated from a study of patients consecutively diagnosed with ocular syphilis who attended a subspecialist uveitis service at one of four hospitals in Brazil over a 30-month period were disaggregated for analysis by gender. Two-hundred and fourteen eyes (161 men and 53 women) of 127 patients (96 men and 31 women) were included. Posterior uveitis was the most common presentation in both men and women (80.1% vs. 66.7%, p > 0.05), but men were significantly more likely to have vitritis as a feature of their disease (49.4% versus 28.8%, p = 0.019). Three eyes of women had nodular anterior scleritis (p = 0.015). Men were more likely to undergo a lumbar puncture to assess for neurosyphilis (71.9% vs. 51.6%, p = 0.048), but men and women undergoing a lumbar puncture were equally likely to have a cerebrospinal fluid abnormality (36.2% vs. 25.0%, p = 0.393). All patients were treated with aqueous penicillin G or ceftriaxone, and there was a trend towards more men receiving adjunctive systemic corticosteroid treatment as part of their management (65.2% vs. 46.7%, p = 0.071). There were no significant differences in the age of presentation, bilaterality of disease, anatomical classification of uveitis, initial or final visual acuity, and rates of ocular complications between men and women. Our findings indicate that ocular syphilis has comparable outcomes in men and women, but that there are differences in the type of ocular inflammation and management practices between the genders. [ABSTRACT FROM AUTHOR]

To investigate the biomechanical factors associated with patellofemoral pain in children and adolescents. A cross-sectional, population-based study conducted in Brazil from 2019 to 2023, involving students from public schools. Adjusted prevalence ratios and their respective 95% confidence intervals for the outcome in relation to independent variables were calculated for association analysis, adopting a significance level of 5%. Out of the total of 283 students, 152 were female and 182 were aged between 16 and 18 years old. A positive association was observed between the presence of patellofemoral pain and a poor movement quality in both lower limbs (right side: p = 0.04 and left side: p = 0.04) as well as with dynamic valgus of the left lower limb (p < 0.01). Patellofemoral pain in children and adolescents is associated with poor movement quality in the lower limbs and dynamic valgus of the left lower limb. Actions targeting these biomechanical factors may be crucial for early diagnosis and clinical treatment of this disfunction. [ABSTRACT FROM AUTHOR]

Excess sugar is considered one of the primary factors contributing to overweight status. In Brazil, sugar-sweetened beverages (SSBs) contain a significant amount of this nutrient and are consumed excessively. These beverages are associated with adverse health outcomes and impose costs on the healthcare system. The literature currently lacks studies that aim to attribute specific nutrients or foods as causes of diseases and also evaluate their economic impact, especially in middle- and low-income countries. This study aims to estimate the direct and indirect costs of obesity, stratified by sex and age group, resulting from the excessive consumption of sugar-sweetened beverages in Brazil from 2008 to 2020, and to project these costs for the year 2036. The estimation of obesity costs attributable to excessive consumption of SSBs was based on relative risks and the population prevalence of obesity, considering expenditures on hospitalizations and outpatient procedures in the Unified Health System (SUS). Cost information was obtained from the health information systems available at SUS. The highest burden attributable to the consumption of SSBs was observed among younger individuals and progressively decreased with advancing age. The total direct costs in the period between 2008 and 2020 amounted to approximately US$ 6.33 million, 87% of which was related to expenses for females. Additionally, deaths resulting from the consumption of SSBs cost the economy US$ 40 million due to the premature loss of productivity. The total costs of obesity attributable to the consumption of SSBs are substantial, impacting public spending and generating social and productivity losses that burden the economy. It is crucial to develop and implement cost-effective fiscal and regulatory policies aimed at preventing and combating obesity. [ABSTRACT FROM AUTHOR]

Countries have pledged to different national and international environmental agreements, most prominently the climate change mitigation targets of the Paris Agreement. Accounting for carbon stocks and flows (fluxes) is essential for countries that have recently adopted the United Nations System of Environmental-Economic Accounting - ecosystem accounting framework (UNSEEA) as a global statistical standard. In this paper, we analyze how spatial carbon fluxes can be used in support of the UNSEEA carbon accounts in five case countries with available in-situ data. Using global multi-date biomass map products and other remotely sensed data, we mapped the 2010–2018 carbon fluxes in Brazil, the Netherlands, the Philippines, Sweden and the USA using National Forest Inventory (NFI) and local biomass maps from airborne LiDAR as reference data. We identified areas that are unsupported by the reference data within environmental feature space (6–47% of vegetated country area); cross-validated an ensemble machine learning (RMSE=9–39 Mg C ha - 1 and R 2 =0.16–0.71) used to map carbon fluxes with prediction intervals; and assessed spatially correlated residuals (<5 km) before aggregating carbon fluxes from 1-ha pixels to UNSEEA forest classes. The resulting carbon accounting tables revealed the net carbon sequestration in natural broadleaved forests. Both in plantations and in other woody vegetation ecosystems, emissions exceeded sequestration. Overall, our estimates align with FAO-Forest Resource Assessment and national studies with the largest deviations in Brazil and USA. These two countries used highly clustered reference data, where clustering caused uncertainty given the need to extrapolate to under-sampled areas. We finally provide recommendations to mitigate the effect of under-sampling and to better account for the uncertainties once carbon stocks and flows need to be aggregated in relatively smaller countries. These actions are timely given the global initiatives that aim to upscale UNSEEA carbon accounting. [ABSTRACT FROM AUTHOR]

A crucial aspect analysed during the last years, aiming to improve sugarcane production, is the impact of climate change on sugarcane productivity. One of the strategies to mitigate climate change's impact on sugarcane yield is the development of new varieties known to positively affect crop production. This paper analysed how climate change impacts sugarcane production regarding the different planted varieties. Data regarding sugarcane harvest were collected from a cooperative in the south of Goiás state—Brazil, the second biggest national sugarcane producer. Results indicate that climate impact on sugarcane yield is irrelevant when controlling for different varieties. Considering the results presented in this work, the Brazilian government should keep the incentives for the development of new sugarcane varieties and, at the same time, spur sugarcane producers to use the new sugarcane varieties. The results imply that if the variety is correctly chosen, sugarcane can be produced without harming the environment, contributing to reaching SDG 15. Moreover, it is less probable that an adverse climatic event will destroy the planted area, preventing sugarcane producers from severe loss and contributing to achieving SDGs number 1 and 2. [ABSTRACT FROM AUTHOR]

A comprehensive mathematical model is proposed to study two strains of dengue virus with saturated incidence rates and quarantine measures. Imperfect dengue vaccination is also assumed in the model. Existence, uniqueness and stability of the proposed model are proved using the results from fixed point and degree theory. Additionally, well constructed Lyapunov function candidates are also applied to prove the global stability of infection-free equilibria. It is also demonstrated that the model is generalized Ulam-Hyers stable under some appropriate conditions. The model is fitted to the real data of dengue epidemic taken from the city of Espirito Santo in Brazil. For the approximate solution of the model, a non-standard finite difference(NSFD) approach is applied. Sensitivity analysis is also carried out to show the influence of different parameters involved in the model. The behaviour of the NSFD is also assessed under different denominator functions and it is observed that the choice of the denominator function could influence the solution trajectories. Different scenario analysis are also assessed when the reproduction number is below or above one. Furthermore, simulations are also presented to assess the epidemiological impact of dengue vaccination and quarantine measures for infected individuals. [ABSTRACT FROM AUTHOR]

Brazil's Atlantic Forest (BAF) is a highly fragmented, strategic environmental and socio-economic region that represents the fourth biodiversity hotspot while also producing many commodities that are exported globally. Human disturbance plays a pivotal role as a driver of BAF's soil dynamics and behaviors. The soils under Late Primary and Secondary Semideciduous Seasonal Forests (LPSF and LSSF) were characterized by high to moderate resilience, with improved chemical properties as human disturbance decreased. The Transitional Forest to Cerrado (TFC) had the worst soil conditions. Disturbed Primary and Secondary Semideciduous Seasonal Forests (DPSF and DSSF) represent a transitional stage between LPSF/LSSF and TFC. Accordingly, SOCs stocks increased from TFC << DPSF, DSSF < LPSF, LSSF. In BAF soils, to avoid unreliable data, SOCs measurements should be (i) conducted to at least 1 m soil depth and (ii) quantified with a CHN analyzer. Human disturbance strongly affected the positive feedback between vegetation succession, SOCs, and soil nutrition. Soil development decreased as human disturbance increased, thus negatively affecting SOCs. Soils in the BAF require a long time to recover after the end of human disturbance, thus suggesting that preservation strategies should be prioritized in remnant BAF fragments. [ABSTRACT FROM AUTHOR]

The advanced stage at diagnosis of colorectal cancer (CRC) may be related to individual factors, socioeconomic conditions, and healthcare service availability. The objective of the study was to analyze the prevalence of advanced stage CRC at the time of diagnosis and its association with individual, contextual, socioeconomic, and healthcare service indicators. An observational, cross-sectional study was conducted, analyzing cases of malignant neoplasms of the colon and rectum in individuals of both sexes, aged between 18 and 99 years, diagnosed between 2010 and 2019 in Brazil (n = 69,047). Data were collected from the Hospital Cancer Registry (HCR), Atlas of Human Development in Brazil, and from the National Registry of Health Institutions (NRHI). A Multilevel Poisson Regression model with random intercept was used. The prevalence of advanced stage CRC at diagnosis was 65.6%. Advanced stage was associated with older age groups prevalence ratio (PR) 4.40 and younger age groups (PR 1.84), low Human Development Index (HDI) (PR 1.22), and low density of family health strategy teams (PR 1.10). The study highlights the unequal distribution of social determinants of health in the diagnosis CRC in Brazil, revealing the need to evaluate and redirect public policies aimed at improving early detection and prevention of CRC in the country. [ABSTRACT FROM AUTHOR]

Vector control is one of the principal strategies used for reducing malaria transmission. Long-lasting insecticidal bed nets (LLINs) are a key tool used to protect populations at risk of malaria, since they provide both physical and chemical barriers to prevent human-vector contact. This study aimed to assess the physical durability and insecticidal efficacy of LLINs distributed in Cruzeiro do Sul (CZS), Brazil, after 4 years of use. A total of 3000 LLINs (PermaNet 2.0) were distributed in high malaria risk areas of CZS in 2007. After 4 years of use, 27 'rectangular' LLINs and 28 'conical' LLINs were randomly selected for analysis. The evaluation of physical integrity was based on counting the number of holes and measuring their size and location on the nets. Insecticidal efficacy was evaluated by cone bioassays, and the amount of residual insecticide remaining on the surface of the LLINs was estimated using a colorimetric method. After 4 years of use, physical damage was highly prevalent on the rectangular LLINs, with a total of 473 holes detected across the 27 nets. The upper portion of the side panels sustained the greatest damage in rectangular LLINs. The overall mosquito mortality by cone bioassay was < 80% in 25/27 rectangular LLINs, with panel A (at the end of the rectangular bednet) presenting the highest mortality (54%). The overall mean insecticide concentration was 0.5 µg/sample, with the bednet roof containing the highest average concentration (0.61 µg/sample). On the conical LLINs, 547 holes were detected, with the bottom areas sustaining the greatest damage. The cone bioassay mortality was < 80% in 26/28 of the conical LLINs. The mean insecticide concentration was 0.3 µg/sample. After 4 years of use, the insecticidal efficacy of the LLINs was diminished to below acceptable thresholds. [ABSTRACT FROM AUTHOR]

Water is a scarce, strategic resource and the most important input for economic development, especially in agricultural countries such as Brazil. Cocoa production is directly related to water availability, and, as climate changes, selecting drought-tolerant genotypes is vital to keep cacao crops sustainable. Here, we evaluated cacao genotypes under irrigated and water-stressed conditions and selected drought-tolerant ones based on nutritional and physiological traits. Thirty-nine genotypes were monitored for three years for agronomic traits and higher fruit yield. After this evaluation, the 18 most promising genotypes were evaluated in a randomized block design, under a 2 (with and without irrigation) × 18 (genotypes) factorial arrangement, with three replicates and five plants per plot. We evaluated seven physiological and 11 nutritional traits, selecting genotypes based on the Genotype-by-Trait Biplot approach. Significant effects (p < 0.05) were observed for the nutritional traits N, P, Mg, S, Zn, Cu, Mn and for the physiological traits CO2 assimilation rate (A), stomatal conductance (gs), transpiration (E), intercellular and atmospheric CO2 concentrations (Ci/Ca), intrinsic water use efficiency (A/gs), instantaneous water use efficiency (A/E), and instantaneous carboxylation efficiency (A/Ci), as determined by analysis of variance. The genotype × irrigation treatment interaction was significant (p < 0.05) for the traits A, gs, and E. Genotypes CP 41, CP 43, and CCN 51 exhibited superior performance for both nutritional and physiological traits (A, gs, and E). In the irrigated environment, CP 41 showed superiority in traits such as P, A/E, A/gs, Mn, S, and Zn. Conversely, under non-irrigated conditions, CP 43 exhibited better performance in nutritional properties, specifically Mn, Mg, and Zn. Notably, in both irrigated and non-irrigated environments, CCN 51 excelled in key physiological traits, including A/Ci, A/E, and A/gs. This robust performance across diverse conditions suggests that these three genotypes possess physiological mechanisms to endure water-stressed conditions. Our research can generate valuable insights into these genotypes informing suitable choices for cocoa cultivation, especially in the context of global climate change. [ABSTRACT FROM AUTHOR]

The World Health Organization has highlighted that cancer was the second-highest cause of death in 2019. This research aims to present the current forecasting techniques found in the literature, applied to predict time-series cancer incidence and then, compare these results with the current methodology adopted by the Instituto Nacional do Câncer (INCA) in Brazil. A set of univariate time-series approaches is proposed to aid decision-makers in monitoring and organizing cancer prevention and control actions. Additionally, this can guide oncological research towards more accurate estimates that align with the expected demand. Forecasting techniques were applied to real data from seven types of cancer in a Brazilian district. Each method was evaluated by comparing its fit with real data using the root mean square error, and we also assessed the quality of noise to identify biased models. Notably, three methods proposed in this research have never been applied to cancer prediction before. The data were collected from the INCA website, and the forecast methods were implemented using the R language. Conducting a literature review, it was possible to draw comparisons previous works worldwide to illustrate that cancer prediction is often focused on breast and lung cancers, typically utilizing a limited number of time-series models to find the best fit for each case. Additionally, in comparison to the current method applied in Brazil, it has been shown that employing more generalized forecast techniques can provide more reliable predictions. By evaluating the noise in the current method, this research shown that the existing prediction model is biased toward two of the studied cancers Comparing error results between the mentioned approaches and the current technique, it has been shown that the current method applied by INCA underperforms in six out of seven types of cancer tested. Moreover, this research identified that the current method can produce a biased prediction for two of the seven cancers evaluated. Therefore, it is suggested that the methods evaluated in this work should be integrated into the INCA cancer forecast methodology to provide reliable predictions for Brazilian healthcare professionals, decision-makers, and oncological researchers. [ABSTRACT FROM AUTHOR]

The Brazilian Organization for Crohn's Disease and Colitis (GEDIIB) established a national registry of inflammatory bowel disease (IBD). The aim of the study was to identify clinical factors associated with disease severity in IBD patients in Brazil. A population-based risk model aimed at stratifying the severity of IBD based on previous hospitalization, use of biologics, and need for surgery for ulcerative colitis (UC) and Crohn's Disease (CD) and on previous complications for CD. A total of 1179 patients (34.4 ± 14.7y; females 59%) were included: 46.6% with UC, 44.2% with CD, and 0.9% with unclassified IBD (IBD-U). The time from the beginning of the symptoms to diagnosis was 3.85y. In CD, 41.2% of patients presented with ileocolic disease, 32% inflammatory behavior, and 15.5% perianal disease. In UC, 46.3% presented with extensive colitis. Regarding treatment, 68.1%, 67%, and 47.6% received biological therapy, salicylates and immunosuppressors, respectively. Severe disease was associated with the presence of extensive colitis, EIM, male, comorbidities, and familial history of colorectal cancer in patients with UC. The presence of Montreal B2 and B3 behaviors, colonic location, and EIM were associated with CD severity. In conclusion, disease severity was associated with younger age, greater disease extent, and the presence of rheumatic EIM. [ABSTRACT FROM AUTHOR]

There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease. From the total of patients enrolled, 2 were excluded since they did not meet eligibility criteria. Among the 2,003 subjects included in the analysis, 55.6% had isolated CAD, 28.7% exclusive PAD and 15.7% had both diagnoses. Overall mean age was 66.3 (± 10.5) years and 65.7% were male patients. Regarding evidence-based therapies (EBTs), 4% were not using any antithrombotic drug and only 1.5% were using vascular dose of rivaroxaban (2.5 mg bid). Only 0.3% of the patients satisfied all the domains of secondary prevention, including prescription of EBTs and targets of body-mass index, blood pressure, LDL-cholesterol, and adherence of lifestyle recommendations. The main barrier for prescription of EBTs was medical judgement. Our findings highlight that the contemporary practice does not reflect a comprehensive approach for secondary prevention and had very low incorporation of new therapies in Brazil. Large-scale populational interventions addressing these gaps are warranted to improve the use of evidence-based therapies and reduce the burden of atherothrombotic disease. ClinicalTrials.gov NCT04677725 [ABSTRACT FROM AUTHOR]

Soil fertility is key point to pastures systems and drives the microbial communities and their functionality. Therefore, an understanding of the interaction between soil fertility and microbial communities can increase our ability to manage pasturelands and maintain their soil functioning and productivity. This study probed the influence of soil fertility on microbial communities in tropical pastures in Brazil. Soil samples, gathered from the top 20 cm of twelve distinct areas with diverse fertility levels, were analyzed via 16S rRNA sequencing. The soils were subsequently classified into two categories, namely high fertility (HF) and low fertility (LF), using the K-Means clustering. The random forest analysis revealed that high fertility (HF) soils had more bacterial diversity, predominantly Proteobacteria, Nitrospira, Chloroflexi, and Bacteroidetes, while Acidobacteria increased in low fertility (LF) soils. High fertility (HF) soils exhibited more complex network interactions and an enrichment of nitrogen-cycling bacterial groups. Additionally, functional annotation based on 16S rRNA varied between clusters. Microbial groups in HF soil demonstrated enhanced functions such as nitrate reduction, aerobic ammonia oxidation, and aromatic compound degradation. In contrast, in the LF soil, the predominant processes were ureolysis, cellulolysis, methanol oxidation, and methanotrophy. Our findings expand our knowledge about how soil fertility drives bacterial communities in pastures. [ABSTRACT FROM AUTHOR]

Dengue fever, a prevalent and rapidly spreading arboviral disease, poses substantial public health and economic challenges in tropical and sub-tropical regions worldwide. Predicting infectious disease outbreaks on a countrywide scale is complex due to spatiotemporal variations in dengue incidence across administrative areas. To address this, we propose a machine learning ensemble model for forecasting the dengue incidence rate (DIR) in Brazil, with a focus on the population under 19 years old. The model integrates spatial and temporal information, providing one-month-ahead DIR estimates at the state level. Comparative analyses with a dummy model and ablation studies demonstrate the ensemble model's qualitative and quantitative efficacy across the 27 Brazilian Federal Units. Furthermore, we showcase the transferability of this approach to Peru, another Latin American country with differing epidemiological characteristics. This timely forecast system can aid local governments in implementing targeted control measures. The study advances climate services for health by identifying factors triggering dengue outbreaks in Brazil and Peru, emphasizing collaborative efforts with intergovernmental organizations and public health institutions. The innovation lies not only in the algorithms themselves but in their application to a domain marked by data scarcity and operational scalability challenges. We bridge the gap by integrating well-curated ground data with advanced analytical methods, addressing a significant deficiency in current practices. The successful transfer of the model to Peru and its consistent performance during the 2019 outbreak in Brazil showcase its scalability and practical application. While acknowledging limitations in handling extreme values, especially in regions with low DIR, our approach excels where accurate predictions are critical. The study not only contributes to advancing DIR forecasting but also represents a paradigm shift in integrating advanced analytics into public health operational frameworks. This work, driven by a collaborative spirit involving intergovernmental organizations and public health institutions, sets a precedent for interdisciplinary collaboration in addressing global health challenges. It not only enhances our understanding of factors triggering dengue outbreaks but also serves as a template for the effective implementation of advanced analytical methods in public health. [ABSTRACT FROM AUTHOR]

Reservoir-triggered seismicity commonly occurs as a result of reservoir impoundment. In particular, the Nova Ponte reservoir triggered a series of earthquakes, including the 1998 M4.0 earthquake, which represents the second-largest earthquake triggered by reservoir impoundment in Brazil. The earthquake occurred after prolonged seismic activity following reservoir impoundment starting in 1993. After more than two decades, the mechanisms governing these earthquakes and their relation with the spatiotemporal evolution of the seismic events are still poorly understood. Here, we explain the causal mechanisms of the two largest earthquakes: an initial response M3.5 in 1995 and the delayed M4.0 in 1998. To this end, we numerically simulate the poromechanical subsurface response to reservoir impoundment using a 3D model that includes three geological layers down to 10 km depth. From the proposed potential nodal planes of the 1995 M3.5 earthquake, we show that the earthquake has most likely occurred on a vertical, E–W-oriented strike-slip fault with a reverse-displacement component. Deviatoric stresses generated by the water column loading on the surface, superimposed by undrained pore pressure enhancement in deep low-permeability layers can explain the fault reactivation. We find that for the 1998 M4.0 earthquake to occur, conductive flow pathways with permeability as high as 6.6·10−15 m2 should exist to transmit pore pressure to a deep critically oriented fault. Our analysis raises the importance of accounting for coupled poromechanical mechanisms controlling fault stability, hydromechanical properties of different rock layers, and realistic shape of the reservoir to accurately assess the potential for reservoir-triggered seismicity. We conclude that reliable forecasting models require accurate subsurface characterization before reservoir filling to enable managing the associated reservoir-triggered seismicity. [ABSTRACT FROM AUTHOR]

This study aimed to analyze the detection and duration of the Zika virus (ZIKV) in plasma, urine, saliva, sweat, rectal swabs, vaginal secretions, breast milk, and semen and to explore risk factors associated with prolonged viral persistence. A prospective cohort study of symptomatic patients and their household contacts was conducted in Brazil from July 2017 to June 2019. A total of 260 individuals (184 women and 76 men) with confirmed ZIKV infection were enrolled and followed up for 12 months. ZIKV RNA was present in all body fluid specimens and detectable for extended periods in urine, sweat, rectal swabs, and semen. The longest detection duration was found in semen, with high viral loads in the specimens. ZIKV RNA clearance was associated with several factors, including age, sex, education level, body mass index, non-purulent conjunctivitis, joint pain, and whether the participant had a history of yellow fever vaccination. The influence of each of these factors on the low or fast viral clearance varied according to the specific body fluid under investigation. Recurrent ZIKV detection events after total viral clearance were observed in the cohort. Our findings provide valuable insights into the persistence and potential recurrence of ZIKV infection, highlighting the need for continued monitoring and follow-up of individuals infected with ZIKV and for effective prevention measures to reduce the risk of transmission. [ABSTRACT FROM AUTHOR]

This study assesses the deterministic and probabilistic forecasting skill of a 1-month-lead ensemble of Artificial Neural Networks (EANN) based on low-frequency climate oscillation indices. The predictand is the February-April (FMA) rainfall in the Brazilian state of Ceará, which is a prominent subject in climate forecasting studies due to its high seasonal predictability. Additionally, the study proposes combining the EANN with dynamical models into a hybrid multi-model ensemble (MME). The forecast verification is carried out through a leave-one-out cross-validation based on 40 years of data. The EANN forecasting skill is compared with traditional statistical models and the dynamical models that compose Ceará's operational seasonal forecasting system. A spatial comparison showed that the EANN was among the models with the smallest Root Mean Squared Error (RMSE) and Ranked Probability Score (RPS) in most regions. Moreover, the analysis of the area-aggregated reliability showed that the EANN is better calibrated than the individual dynamical models and has better resolution than Multinomial Logistic Regression for above-normal (AN) and below-normal (BN) categories. It is also shown that combining the EANN and dynamical models into a hybrid MME reduces the overconfidence of the extreme categories observed in a dynamically-based MME, improving the reliability of the forecasting system. [ABSTRACT FROM AUTHOR]

The Harpy Eagle (Harpia harpyja) is threatened with extinction throughout its distribution in the neotropical forests. In the Atlantic Forest, deforestation has reduced the number of suitable habitats, with only a few remnant forest fragments hosting active nests; currently, the only known nests in this region are in the Central Atlantic Forest Ecological Corridor (CAFEC), in Brazil. Little is known about Harpy Eagle diets in this region, despite this information being essential for developing effective conservation strategies. We classified the composition, frequency, richness, ecological attributes, and conservation status of the species that make up the Harpy Eagle's diet in its last refuges in the CAFEC. Between 2017 and 2021, we collected and analyzed 152 prey remains and 285 camera trap photographs from seven active nests. We identified at least 16 mammal species (96.7%), one parrot and other bird remains (3.3%). The Harpy Eagle's diet consisted mainly of medium-sized arboreal, folivorous, frugivorous, and diurnal mammals. Five prey species are currently threatened with extinction at global, six at national and seven at regional levels. The majority of the diet consists of Sapajus robustus, which is threatened, and Bradypus variegatus, which is not threatened. In addition to the effects of habitat loss and hunting, the Harpy Eagle may also suffer from the decline in the populations of their prey in the Atlantic Forest. [ABSTRACT FROM AUTHOR]

Women in prison have high risk for non-communicable diseases both in relation to men in prison and in relation to women in the general population. This study documented the health disparities related to diseases among women in prison and in the general female population in Brazil. Women in prisons (WP) < 30 years old had a prevalence of hypertension (PR = 4.5; 95% CI 3.4–6.1), cardiovascular disease (PR = 4.4; 95% CI 2.4–7.9) and asthma (PR = 3.0; 95% CI 2.3–3.8) higher than general female population in Brazil in the same age group. Women in prison > 50 years old also presented asthma prevalence (PR = 4.3; 95% CI 2.9–6.3) higher than the general female population in Brazil in the same age group. These women in prison, overwhelmingly young, could be mistaken for an elderly population in Brazil. Actively responding to early disease in these women can reduce overall health costs and improve health care for this population that may have limited access to health care outside of prison. [ABSTRACT FROM AUTHOR]

Acute neurological emergencies are highly prevalent in intensive care units (ICUs) and impose a substantial burden on patients. This study aims to describe the epidemiology of patients requiring neurocritical care in Brazil, and their differences based on primary acute neurological diagnoses and to identify predictors of mortality and unfavourable outcomes, along with the disease burden of each condition at intensive care unit admission. This prospective cohort study included patients requiring neurocritical care admitted to 36 ICUs in four Brazilian regions who were followed for 30 days or until ICU discharge (Aug-Sep in 2018, 1 month). Of 4245 patients admitted to the participating ICUs, 1194 (28.1%) were patients with acute neurological disorders requiring neurocritical care and were included. Patients requiring neurocritical care had a mean mortality rate 1.7 times higher than ICU patients not requiring neurocritical care (17.21% versus 10.1%, respectively). Older age, emergency admission, higher number of potential secondary injuries, and worse APACHE II, SAPS III, SOFA, and Glasgow coma scale scores on ICU admission are independent predictors of mortality and poor outcome among patients with acute neurological diagnoses. The estimated total DALYs were 4482.94 in the overall cohort, and the diagnosis with the highest DALYs was traumatic brain injury (1634.42). Clinical, epidemiological, treatment, and ICU outcome characteristics vary according to the primary neurologic diagnosis. Advanced age, a lower GCS score and a higher number of potential secondary injuries are independent predictors of mortality and unfavourable outcomes in patients requiring neurocritical care. The findings of this study are essential to guide education policies, prevention, and treatment of severe acute neurocritical diseases. [ABSTRACT FROM AUTHOR]

The Harpy Eagle (Harpia harpyja) is threatened with extinction throughout its distribution in the neotropical forests. In the Atlantic Forest, deforestation has reduced the number of suitable habitats, with only a few remnant forest fragments hosting active nests; currently, the only known nests in this region are in the Central Atlantic Forest Ecological Corridor (CAFEC), in Brazil. Little is known about Harpy Eagle diets in this region, despite this information being essential for developing effective conservation strategies. We classified the composition, frequency, richness, ecological attributes, and conservation status of the species that make up the Harpy Eagle's diet in its last refuges in the CAFEC. Between 2017 and 2021, we collected and analyzed 152 prey remains and 285 camera trap photographs from seven active nests. We identified at least 16 mammal species (96.7%), one parrot and other bird remains (3.3%). The Harpy Eagle's diet consisted mainly of medium-sized arboreal, folivorous, frugivorous, and diurnal mammals. Five prey species are currently threatened with extinction at global, six at national and seven at regional levels. The majority of the diet consists of Sapajus robustus, which is threatened, and Bradypus variegatus, which is not threatened. In addition to the effects of habitat loss and hunting, the Harpy Eagle may also suffer from the decline in the populations of their prey in the Atlantic Forest. [ABSTRACT FROM AUTHOR]

Wastewater-based epidemiology (WBE) becomes an interesting epidemiological approach to monitoring the prevalence of SARS-CoV-2 broadly and non-invasively. Herein, we employ for the first time WBE, associated or not with the PEG 8000 precipitation method, for the detection of SARS-CoV-2 in samples of raw or treated wastewater from 22 municipal wastewater treatment stations (WWTPs) located in Salvador, the fourth most populous city in Brazil. Our results demonstrate the success of the application of WBE for detecting SARS-CoV-2 in both types of evaluated samples, regardless of the usage of PEG 8000 concentration procedure. Further, an increase in SARS-CoV-2 positivity rate was observed in samples collected in months that presented the highest number of confirmed COVID-19 cases (May/2021, June/2021 and January/2022). While PEG 8000 concentration step was found to significantly increase the positivity rate in treated wastewater samples (p < 0.005), a strong positive correlation (r: 0.84; p < 0.002) between non-concentrated raw wastewater samples with the number of new cases of COVID-19 (April/2021–February/2022) was observed. In general, the present results reinforce the efficiency of WBE approach to monitoring the presence of SARS-CoV-2 in either low- or high-capacity WWTPs. The successful usage of WBE even in raw wastewater samples makes it an interesting low-cost tool for epidemiological surveillance. [ABSTRACT FROM AUTHOR]

The SARS-CoV-2 (COVID-19) pandemic impacted the health systems between and within countries, and in the course of the pandemic sexual and reproductive health services were the most disrupted. Findings from high-income settings have reported significant changes in preterm birth prevalence during the pandemic period. To understand the possible effects of the COVID-19 pandemic on preterm birth numbers at the Brazilian national level. We compare the number of preterm deliveries during the COVID-19 pandemic period (2020 and 2021) with previous years. We conducted a population-based cross-sectional study taking the period from January 2017 to December 2021 to account. We use individual-level live births data from the Brazilian Live Birth Information System (SINASC), and we estimate the odds ratio (OR) of preterm deliveries using propensity score weighting analysis in Brazil and its regions. During the study period (from 2017 to 2021), about 2.7 million live births were recorded per year, and the missing value for gestational age at delivery was less than 1.5%. The preterm birth prevalence slightly increased during the COVID-19 pandemic compared to the pre-pandemic period (11.32% in 2021 vs 11.09% in 2019, p-value < 0.0001). After adjusting for sociodemographic variables, the OR of preterm births in Brazil has significantly increased, 4% in 2020 (OR: 1.04 [1.03–1.05] 95% CI, p-value < 0.001), and 2% in 2021(OR: 1.02 [1.01–1.03] 95% CI, p-value < 0.001), compared to 2019. At the regional level, the preterm birth pattern in the South, Southeast and Northeast regions show a similar pattern. The highest odds ratio was observed in the South region (2020 vs 2019, OR: 1.07 [1.05–1.10] 95% CI; 2021 vs 2019, OR: 1.03 [1.01–1.06] 95% CI). However, we also observed a significant reduction in the ORs of preterm births in the northern region during the COVID-19 pandemic (2020 vs 2019, OR: 0.96 [0.94–0.98] 95% CI) and (2021 vs 2019, OR: 0.97 [0.95–0.99] 95% CI). Our analysis shows that the pandemic has increased regional variation in the number of preterm births in Brazil in 2020 and 2021 compared to the pre-pandemic years. [ABSTRACT FROM AUTHOR]

Despite previous reports of SARS-CoV-2 infection in dogs and cats worldwide, the type of swab sample used for its detection through RT-qPCR needs to be better compared and described. Accordingly, as part of a multicenter study in Brazil, the aim of the present study was to assess which rectal or oropharyngeal swabs would be more appropriate for detecting SARS-CoV-2 in cats and dogs, through viral load comparison. Pets of owners diagnosed with COVID-19 in the last 7 days were eligible. A total of 148 animals from four of the five Brazilian geographical regions were analyzed, among which 10/48 cats (20.83%) and 11/100 dogs (11.00%) were positive. The results suggested that oropharyngeal swabs should be considered for SARS-CoV-2 detection, particularly in cats, due to the higher cDNA viral load. Also, the genomic results showed similarities between SARS-CoV-2 animal variants and human variants that were circulating at the time of sampling, thus corroborating the existence of zooanthroponotic transmission. In conclusion, the present study highlighted the importance of SARS-CoV-2 monitoring among cats and dogs, as virus modification may indicate the possibility of mutations in animals and spillover back to owners. Thus, positive individuals should always self-isolate from their pets during COVID-19, to prevent trans-species transmission and mutation. [ABSTRACT FROM AUTHOR]

Eucalyptus plantations around the world have been largely used by the paper industry. Optimizing the management of resources is a common practice in this highly competitive industry and new forest growth models may help to understand the impact of climate change on the decisions of the optimization processes. Current optimized management plans use empirical equations to predict future forest stands growth, and it is currently impractical to replace these empirical equations with physiological models due to data input requirements. In this paper, we present a different approach, by first carrying out a preliminary assessment with the process-based physiological model 3PG to evaluate the growth of Eucalyptus stands under climate change predictions. The information supplied by 3PG was then injected as a modifier in the projected yield that feeds the management plan optimizer allowing the interpretation of climate change impacts on the management plan. Modelling results show that although a general increase of rain with climate change is predicted, the distribution throughout the year will not favor the tree growth. On the contrary, rain will increase when it is less needed (summer) and decrease when it is most needed (winter), decreasing forest stand productivity between 3 and 5%, depending on the region and soil. Evaluation of the current optimized plan that kept constant the relation between wood price/cellulose ton shows a variation in different strategic management options and an overall increase of costs in owned areas between 2 and 4%, and a decrease of cumulated net present value, initially at 15% with later stabilization at 6–8%. This is a basic comparison to observe climate change effects; nevertheless, it provides insights into how the entire decision-making process may change due to a reduction in biomass production under future climate scenarios. This work demonstrates the use of physiological models to extract information that could be merged with existing and already implemented empirical models. The methodology may also be considered a preliminary alternative to the complete replacement of empirical models by physiological models. Our approach allows some insight into forest responses to different future climate conditions, something which empirical models are not designed for. [ABSTRACT FROM AUTHOR]

Prevention of mother-to-child transmission programs have been one of the hallmarks of success in the fight against HIV/AIDS. In Brazil, access to antiretroviral therapy (ART) during pregnancy has increased, leading to a reduction in new infections among children. Currently, lifelong ART is available to all pregnant, however yet challenges remain in eliminating mother-to-child transmission. In this paper, we focus on the role of near-infrared (NIR) spectroscopy to analyse blood plasma samples of pregnant women with HIV infection to differentiate pregnant women without HIV infection. Seventy-seven samples (39 HIV-infected patient and 38 healthy control samples) were analysed. Multivariate classification of resultant NIR spectra facilitated diagnostic segregation of both sample categories in a fast and non-destructive fashion, generating good accuracy, sensitivity and specificity. This method is simple and low-cost, and can be easily adapted to point-of-care screening, which can be essential to monitor pregnancy risks in remote locations or in the developing world. Therefore, it opens a new perspective to investigate vertical transmission (VT). The approach described here, can be useful for the identification and exploration of VT under various pathophysiological conditions of maternal HIV. These findings demonstrate, for the first time, the potential of NIR spectroscopy combined with multivariate analysis as a screening tool for fast and low-cost HIV detection. [ABSTRACT FROM AUTHOR]

The Brazilian government's decision to open the Amazon biome to sugarcane expansion reignited EU concerns regarding the sustainability of Brazil's sugar sector, hindering the ratification of the EU-Mercosur trade agreement. Meanwhile, in the EU, certain conventional biofuels face stricter controls, whilst uncertainty surrounding the commercialisation of more sustainable advanced-biofuels renders bioethanol as a short- to medium-term fix. This paper examines Brazil's land-use changes and associated greenhouse gas emissions arising from an EU driven ethanol import policy and projections for other 13 biocommodities. Results suggest that Brazil's sugarcane could satisfy growing ethanol demand and comply with EU environmental criteria, since almost all sugarcane expansion is expected to occur on long-established pasturelands in the South and Midwest. However, expansion of sugarcane is also driven by competition for viable lands with other relevant commodities, mainly soy and beef. As a result, deforestation trends in the Amazon and Cerrado biomes linked to soy and beef production could jeopardize Brazil's contribution to the Paris agreement with an additional 1 ± 0.3 billion CO2eq tonnes above its First NDC target by 2030. Trade talks with a narrow focus on a single commodity could thus risk unsustainable outcomes, calling for systemic sustainability benchmarks, should the deal be ratified. [ABSTRACT FROM AUTHOR]

The adoption of strategies for monitoring water consumption is essential for water resources management, contributing to the promotion of the sustainability in the water sector. Statistical process control (SPC) charts, which are widely used in the industrial sector, are statistical methods developed to improve the quality of products and processes. The application of this method has reached other areas over the last decades and has recently been identified as an option for environmental monitoring. In this context, the application of SPC charts emerges as an option for water consumption monitoring, whether in a building or an urban scale. Thus, this article aims to analyze the application of statistical process control charts in the monitoring of water consumption of two housing compounds in Joinville, southern Brazil. The methodological procedures include the use of the Shewhart and the EWMA control charts in addition to the non-parametric alternative, the EWMA-SN, assessing the effectiveness of these techniques in detecting water leaks in residential apartment buildings. The data sets, obtained through a telemetry metering system from the water utility, represent a period of 243 days. The results show that control charts are a powerful tool in identifying changes in water consumption patterns, with the EWMA chart flagging the leaks sooner. [ABSTRACT FROM AUTHOR]

To compare the performance of SARC-F and SARC-CalF as screening tools for sarcopenia. Cross-sectional study with a convenience sample of 312 community-dwelling older people. Sarcopenia was defined as low handgrip strength (HGS) or low gait speed (GS ≤ 0.8 m/s). HGS was measured by dynamometry and GS by the 4-m walking speed test. For HGS, six criteria (C) were used to identify sarcopenia in men/women: CI: < 27 kg/16 kg; CII: < 35.5 kg/20.0 kg; CIII: grip over body mass index < 1.05/< 0.79; CIV: grip strength over total body fat < 1.66/< 0.65; CV: grip over bodyweight < 0.45/< 0.34; CVI: < 27 kg/16 kg and low skeletal muscle mass index (SMMI); CI and CVI defined according to the European Working Group on sarcopenia in older people and the rest according to the sarcopenia definition and outcomes Consortium. For sarcopenia screening, the SARC-F (≥ 4 points) and the SARC-CalF (≥ 11 points) were used. The kappa analysis revealed no agreement between the SARC-F and the various criteria for the identification of sarcopenia in men. The same lack of agreement was observed in women with some exceptions: CI = 0.161 ± 0.074, p = 0.020; GS = 0.209 ± 0.076, p = 0.003. Concerning the Cohen's kappa between the SARC-Calf and the reference criteria of sarcopenia, the following coefficients were observed as significant for women: CI = 0.201 ± 0.069, p = 0.003; CII = 0.186 ± 0.064, p = 0.005; GS = 0.273 ± 0.068, p = 0.0001; and for men: CII = 0.139 ± 0.053, p = 0.021; GS = 0.223 ± 0.099, p = 0.011. ROC curves revealed the SARC-Calf with acceptable discrimination and reasonable sarcopenia predictive capacity considering a cutoff value of 10.5 in both men (AUC: 67.5%, p = 0.022; Se = 52.9%; Sp = 76.8%) and women (AUC: 72.4%, p < 0.001; Se = 63%; Sp = 68.5%) concerning GS. The SARC-CalF performed better than the SARC-F for screening sarcopenia in the population ≥ 60 years of age in the Amazonas, measured through walking slowness. [ABSTRACT FROM AUTHOR]

The adult holotype of the fossil mayfly Astraeoptera cretacica Brandão et al. 2021 from the Cretaceous Crato Formation, Brazil, is reviewed and attributed to a new family Astraeopteridae fam. nov. Based on alate specimens, we also describe further new representatives of Astraeopteridae fam. nov., namely Astraeoptera vitrea sp. nov. and Astraeoptera oligovenata sp. nov., as well as the new genus and species Eosophobia acuta gen. et sp. nov. A subsequent character analysis of the new material suggests systematic affinities of Astraeopteridae fam. nov. with those extant families of Siphlonuroidea distributed in the Southern Hemisphere. These newly described fossil Siphlonuroidea from the Cretaceous of Brazil thus add to the biogeography and systematics of mayflies. [ABSTRACT FROM AUTHOR]

Over the last few years, understanding of the effects of increasingly interconnected global flows of agricultural commodities on coupled human and natural systems has significantly improved. However, many important factors in environmental change that are influenced by these commodity flows are still not well understood. Here, we present an empirical spatial modelling approach to assess how changes in forest cover are influenced by trade destination. Using data for soybean-producing municipalities in the state of Mato Grosso, Brazil, between 2004 and 2017, we evaluated the relationships between forest cover change and the annual soybean trade destination. Results show that although most of the soybean produced in Mato Grosso during the study period (60%) was destined for international markets, municipalities with greater and more consistent soybean production not destined for international markets during the study period were more strongly associated with deforestation. In these municipalities, soybean production was also significantly correlated with cattle and pasture expansion. These results have important implications for the sustainable management of natural resources in the face of an increasingly interconnected world, while also helping to identify the most suitable locations for implementing policies to reduce deforestation risks. [ABSTRACT FROM AUTHOR]

Whilst Brazil is the fourth largest cotton producer globally, incidence of ramularia leaf spot (RLS) has decreased yield. In 2017–18 and 2018–19, ca. 300 fungal samples were collected throughout Brazil. Hyphal tip cultures were obtained for amplification of the RNA polymerase II (RPB2), 28S rRNA, the ribosomal DNA internal transcribed spacers (ITS), actin (ACT), elongation factor (EF1-α) and histone H3 (HIS3) genomic regions. Additionally, sequences of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were obtained by nanopore sequencing and the EF1-α region was selected as a marker for rapid recognition of Ramulariopsis species. Clade assignments based on the concatenated-sequence tree were identical to those in tree generated by RPB2-sequences, as well as in an RPB2 haplotype network and an ISSR (TGTC)4 dendrogram, in identification with species-specific primers and based on morphological comparisons. Out of 267 examined isolates, 252 were identified as Ramulariopsis pseudoglycines, indicating this species as the most widespread causal agent of cotton RLS in the Brazilian growing regions. Species-specific primers developed in the study that target the EF1-α gene provide an opportunity for extensive RLS sampling worldwide to study the distribution of Ramulariopsis species. Such data will aid breeders and plant pathologists in cotton disease resistance development and fungicide resistance avoidance. [ABSTRACT FROM AUTHOR]

Dating back to the late Early Cretaceous, the macrofossil record of the iconic lotus family (Nelumbonaceae) is one of the oldest of flowering plants and suggests that their unmistakable leaves and nutlets embedded in large pitted receptacular fruits evolved relatively little in the 100 million years since their first known appearance. Here we describe a new fossil from the late Barremian/Aptian Crato Formation flora (NE Brazil) with both vegetative and reproductive structures, Notocyamus hydrophobus gen. nov. et sp. nov., which is now the oldest and most complete fossil record of Nelumbonaceae. In addition, it displays a unique mosaic of ancestral and derived macro- and micromorphological traits that has never been documented before in this family. This new Brazilian fossil-species also provides a rare illustration of the potential morphological and anatomical transitions experienced by Nelumbonaceae prior to a long period of relative stasis. Its potential plesiomorphic and apomorphic features shared with Proteaceae and Platanaceae not only fill a major morphological gap within Proteales but also provide new support for their unexpected relationships first suggested by molecular phylogenies. [ABSTRACT FROM AUTHOR]

Clinical research outcomes depend on the correct definition of the research protocol, the data collection strategy, and the data management plan. Furthermore, researchers often need to work within challenging contexts, as is the case in tuberculosis services, where human and technological resources for research may be scarce. Electronic Data Capture Systems mitigate such risks and enable a reliable environment to conduct health research and promote result dissemination and data reusability. The proposed solution is based on needs pinpointed by researchers, considering the need for an accommodating solution to conduct research in low-resource environments. The REDbox framework was developed to facilitate data collection, management, sharing, and availability in tuberculosis research and improve the user experience through user-friendly, web-based tools. REDbox combines elements of the REDCap and KoBoToolbox electronic data capture systems and semantics to deliver new valuable tools that meet the needs of tuberculosis researchers in Brazil. The framework was implemented in five cross-institutional, nationwide projects to evaluate the users' perceptions of the system's usefulness and the information and user experience. Seventeen responses (representing 40% of active users) to an anonymous survey distributed to active users indicated that REDbox was perceived to be helpful for the particular audience of researchers and health professionals. The relevance of this article lies in the innovative approach to supporting tuberculosis research by combining existing technologies and tailoring supporting features. [ABSTRACT FROM AUTHOR]

Human mobility plays a key role in the dissemination of infectious diseases around the world. However, the complexity introduced by commuting patterns in the daily life of cities makes such a role unclear, especially at the intracity scale. Here, we propose a multiplex network fed with 9 months of mobility data with more than 107 million public bus validations in order to understand the relation between urban mobility and the spreading of COVID-19 within a large city, namely, Fortaleza in the northeast of Brazil. Our results suggest that the shortest bus rides in Fortaleza, measured in the number of daily rides among all neighborhoods, decreased ≈ 25 % more than the longest ones after an epidemic wave. Such a result is the opposite of what has been observed at the intercity scale. We also find that mobility changes among the neighborhoods are synchronous and geographically homogeneous. Furthermore, we find that the most central neighborhoods in mobility are the first targets for infectious disease outbreaks, which is quantified here in terms of the positive linear relation between the disease arrival time and the average of the closeness centrality ranking. These central neighborhoods are also the top neighborhoods in the number of reported cases at the end of an epidemic wave as indicated by the exponential decay behavior of the disease arrival time in relation to the number of accumulated reported cases with decay constant λ ≈ 33 days. We believe that these results can help in the development of new strategies to impose restriction measures in the cities guiding decision-makers with smart actions in public health policies, as well as supporting future research on urban mobility and epidemiology. [ABSTRACT FROM AUTHOR]

The end-Triassic extinction (ETE) event represents one of the 'big five' episodes of mass extinction. The leading hypothesis for the cause of the ETE is the intrusion of voluminous magmas of the Central Atlantic Magmatic Province (CAMP) into carbon-rich sediments of two South American sedimentary basins, around 201.5 Ma. The timing of dikes and sills emplacement, however, must be considered in light of age models from CAMP rocks occurring in North America. In this work, we present new high-precision ages for critical samples in NE Brazil (201.579 ± 0.057 Ma) and Canada (201.464 ± 0.017 Ma), in order to evaluate how the South and North American magmatic events compare at the 100-ka level, and to the ETE timing. We also discuss inter-laboratory reproducibility of high-precision CAMP ages, including the 230Th disequilibrium corrections that are made to zircon U–Pb dates. Our findings in this newly discovered extension of the CAMP large igneous province in NE Brazil support the hypothesis that the CAMP may be responsible for the ETE through the triggering of greenhouse gas release from magma-evaporite interactions (contact metamorphism) in the South American basins. [ABSTRACT FROM AUTHOR]

Accurately determining an aircraft's flight speed is crucial for optimizing airline performance, as it directly impacts factors such as fuel consumption and emissions. Flying at speeds higher than what is recommended by the manufacturer can result in increased fuel burn. However, flying at slower speeds may lead to longer flight times and competitive disadvantages for airlines as passengers typically prefer shorter travel times. This study empirically investigates the driving forces in the decision-making process of airlines when setting flight speeds to reduce costs while maintaining the quality of service provided to customers. We develop econometric models of planned flight cruise speed and actual mean flight speed. We analyze a vast amount of data, comprising millions of domestic flights within Brazil. Our results allow for policy recommendations that identify opportunities for improvements in airline flight operations optimization, with implications for the environmental footprint of commercial aviation. [ABSTRACT FROM AUTHOR]

Escherichia coli O157:H7 is a foodborne pathogen, which causes various health conditions in humans, including fatigue, nausea, bloody diarrhoea and in some cases, even death. In 2017, 15.71% of the total imported food products in Saudi Arabia (SA) were meat-based. India and Brazil are two of the top five countries from where SA imports meat. According to the Saudi Food and Drug Authority, in 2017, at least 562, 280, and 50 samples of imported beef, chicken and sheep meat, respectively, were tested for the presence of E. coli O157:H7. Amongst these, E. coli O157:H7 was detected in respectively 6.80% and 2.20% of the tested beef meat samples imported from India and Brazil as well as in respectively 6.96% and 3.57% of the tested chicken samples imported from Brazil and Ukraine. Moreover, the pathogen was detected in 2.13% of the tested sheep meat samples imported from India. The present report provides evidence that imported meat can serve as the carrier of E. coli O157:H7, which may lead to epidemics within the Kingdom of Saudi Arabia. [ABSTRACT FROM AUTHOR]

This study analyzes the genomic findings of the first report of Salmonella isolate carrying the blaCTX-M-55 gene, recovered from a bacteremic patient from Brazil. A bacterial isolate positive for the blaCTX-M-55 gene was submitted to antimicrobial susceptibility testing by disk diffusion and epsilometric test. Whole genome sequencing was performed using Illumina technology. Conjugation assay was performed; plasmid sizes determined by S1-PFGE and plasmid content were investigated by hybrid assembly after MinION long reads sequencing. Isolate 288_18 was identified as sequence type ST13, resistant to ampicillin, cefotaxime, ceftazidime, cefepime, ceftriaxone, and aztreonam. A transferable IncFII plasmid sized approximately 67 kb was found to carry the blaTEM-1 and blaCTX-M-55 in a module consisting of IS26-blaTEM-1B-WbuC-blaCTX-M-55-IS26. In addition, an 117 kb IncI1plasmid was also identified in the 288_18 isolate, but without additional resistance genes. To the best of our knowledge, this is the first report of blaCTX-M-55 in Salmonella isolated from human infection in Brazil. The occurrence of blaCTX-M-55 in the IncFII epidemic plasmid in a relevant clinical human isolate of Salmonella Agona underscores the urgent need for enhanced and effective continuous surveillance for controlling its dissemination. [ABSTRACT FROM AUTHOR]

Genetic compositions of distinct human populations are different. How genomic variants influence many common and rare genetic diseases is always of great medical and anthropological interest, and understanding of genetic architectures of population groups in relation to diseases can advance our knowledge of medicine. Here, we have studied the genomic architecture of a group of Xavante Indians, an indigenous population in Brazil, and compared them with normal populations from the 1000 Genomes Projects. Principal component analysis (PCA) indicates that the Xavante Indians are genetically distinctive when compared to other ethnic groups. No incidence of breast cancer cases has ever been reported in the population, and polygenic risk analysis indicates extremely low breast cancer risk in this population when compared with germline TCGA (The Cancer Genome Atlas) breast cancer normal control samples. Low germinal mutation burden among this population is also observed. Our findings will help to deepen the understanding of breast cancer and might also provide new approaches to study the disease. [ABSTRACT FROM AUTHOR]

Although studies have quantified the current burden of diseases attributable to overweight and obesity in Brazil, none have estimated its burden in the future. The study aimed to estimate the potential impact of different scenarios of changes in the prevalence of overweight on non-communicable diseases (NCD) in the Brazilian adult population until 2030. We developed a multistate life table model including 11 body mass index (BMI) related diseases to estimate attributable NCDs cases and deaths under the following scenarios of changes in overweight over a 10-year simulation: (1) the continuity of the current trajectory of BMI increases, (2) reducing the rate of increase by half, (3) stopping future BMI increases, and (4) the reduction of the prevalence of overweight by 6.7%. In Brazil, if the current trends of BMI increase are maintained from 2021 to 2030, approximately 5.26 million incident cases and 808.6 thousand deaths from NCDs may occur due to overweight. If the annual increase in overweight was reduced by half until 2030, 1.1% of new NCD cases and 0.2% of deaths could be prevented (respectively, 29,600 cases and 1900 deaths). Alternatively, if the current prevalence of overweight is maintained, as set as a national goal in Brazil until 2030, the incident NCD cases and the deaths could be reduced by respectively 3.3% (92,900) and 1.5% (12,100) compared to continuation of current trends. If the prevalence of overweight is reduced by 6.7% until 2030, 6.5% (182,200) of NCD cases and 4.2% (33,900) of deaths could be prevented. The epidemiologic burden of overweight in Brazil tends to increase if bold policy interventions are not adopted in Brazil. [ABSTRACT FROM AUTHOR]