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This study investigates the predictors of consistent condom use among male construction workers in South Africa who reported concurrent sexual relationships with regular partners, casual partners, and sex workers over a 3-month period. A cross-sectional survey was used to collect data from a convenience sample of 450 male workers across 18 construction work sites in the Western Cape province. Of these, 245 (54%) indicated that they had engaged in sex with all three partner types during the 3-month study period. Hierarchical multiple linear regression was then used to assess consistent condom use as a function of demographic, experiential, behavioural and cognitive characteristics. Three statistically significant predictors of consistent condom use were identified: perceived control over condom use (β = 0.252, p < 0.001), positive attitude toward condom use (β = 0.154, p < 0.05) and fear of HIV infection (β = 0.121, p < 0.05). These findings highlight the high prevalence of sexual concurrency among study participants. It also suggests that amid declining condom use, interventions which focus on enhancing an individuals’ condom application skills and efficacy, that foster positive attitudes toward condom use and that strategically incorporate fear-based messaging within a multilevel framework may potentially increase condom use among individuals in concurrent sexual relationships. [ABSTRACT FROM AUTHOR]

Background: Human Immunodeficiency Virus (HIV) and malaria are two major diseases in sub-Saharan Africa. Co-infection can significantly impact the clinical outcomes of both conditions. We assessed the proportion of HIV-infected children at Korle Bu Teaching Hospital (KBTH) and Princess Marie Louise Hospital (PML) with malaria parasites. The association between asymptomatic malaria parasitaemia and virological non-suppression was also determined in these children. Methods: This cross-sectional study of 277 asymptomatic malaria in children receiving care at paediatric HIV clinics at KBTH and PML was conducted from September to November 2022. Patients who had been on antiretroviral therapy (ART) for at least six months were eligible to participate. Structured questionnaires were used to collect socio-demographic information, malaria prevention behaviors, and ART-related data using in-person interviews. Microscopy and PCR were used to screen for malaria, and GeneXpert was used to determine viral load. To examine the determinants of malaria PCR positivity and virological non-suppression, chi-square tests and logistic regression were performed. Results: The median age of the participants was 9 years (range: 6–12 years). Males comprised 158 (57%) of the study population. We detected 10 (3.6%) and 21 (7.6%) malaria cases by microscopy and PCR, respectively. Virological non-suppression (VL > 1000 copies/ml) was observed in 82 (29.6%) of the 277 participants. Among the suppressed individuals, 62 (22.4%) exhibited low-level viraemia (VL level 40-1000 copies/ml) and 133 (48%) had undetectable viral load levels. No factors were associated with the presence of malaria PCR positivity carriage. Poor adherence to ART was associated with a five-fold increase in the risk of viral load non-suppression (AOR = 4.89 [CI = 2.00-11.98], p = 0.001). Conclusion: The proportion of children living with HIV with asymptomatic malaria parasitaemia was low. Approximately one-third of the study population had virological non-suppression. The interaction between malaria parasitemia and viral replication may not be the main cause for virological non-suppression in this low transmission area. [ABSTRACT FROM AUTHOR]

We conducted a scoping review to ascertain the landscape of ethics regulations for AD/ADRD research in Africa using Arksey and O'Malley's framework. We sourced regulations from the International Compilation of Human Research Standards. We included regulations from 14 countries published between 1997 and 2020. Provisions in the regulations applicable to research in AD/ADRD were part of broader sub‐provisions for research such as with persons under legal disability. Regulations mostly required the appointment of Legally Authorised Representatives, as a major protection for persons with AD/ADRD. Provisions supporting capacity assessment and advance directives were only provided in regulations from five and two countries respectively. No regulation cited the Convention on the Rights of Persons with Disabilities as a foundational instrument for its provisions. In conclusion, regulations specifically applicable to research among AD/ADRD or other cognitively impaired persons in Africa are scarce and provisions in existing regulations mostly lack specificity for practical implementation. [ABSTRACT FROM AUTHOR]

Midwives in Low- and middle-income countries, experience myriad barriers that have consequences for them and for maternity care. This article provides insight into the consequences of the barriers that Ghanaian midwives face in their workplaces. Glaserian Grounded Theory methodology using semi-structured interviews and non-participant observations was applied in this study. The study participants comprised of 29 midwives and a pharmacist, a social worker, a health services manager, and a National Insurance Scheme manager in Ghana. Data collection and analysis occurred concurrently while building on already analyzed data. In this study it was identified that barriers to Ghanaian midwives' ability to provide maternity care can have physiological, psychological, and socioeconomic consequences for midwives. It also negatively impacted maternity care. Implementing new ameliorating measures to mitigate the barriers that Ghanaian midwives encounter, and the consequences that those barriers have on them would improve midwife retention and care quality. [ABSTRACT FROM AUTHOR]

AbstractPredicting the mechanical response of materials subjected to transient heat processes is crucial in various engineering applications. This paper introduces a novel peridynamic (PD) coupled field model formulated within the framework of Non-Ordinary State-Based Peridynamics (NOSBPD). This model offers the capability to simulate the coupled thermo-mechanical behavior of materials by incorporating both thermal transport and mechanical deformation analyses. To verify the model’s accuracy, a benchmark problem involving a steel plate undergoing transient thermal expansion is investigated. This model presents a valuable tool for various engineering applications involving coupled thermo-mechanical processes. [ABSTRACT FROM AUTHOR]

The recent global outbreaks of infectious diseases such as COVID-19, yellow fever, and Ebola have highlighted the critical need for robust health data management systems that can rapidly adapt to and mitigate public health emergencies. In contrast to traditional systems, this study introduces an innovative blockchain-based Electronic Health Record (EHR) access control mechanism that effectively safeguards patient data integrity and privacy. The proposed approach uniquely integrates granular data access control mechanism within a blockchain framework, ensuring that patient data is only accessible to explicitly authorized users and thereby enhancing patient consent and privacy. This system addresses key challenges in healthcare data management, including preventing unauthorized access and overcoming the inefficiencies inherent in traditional access mechanisms. Since the latency is a sensitive factor in healthcare data management, the simulations of the proposed model reveal substantial improvements over existing benchmarks in terms of reduced computing overhead, increased throughput, minimized latency, and strengthened overall security. By demonstrating these advantages, the study contributes significantly to the evolution of health data management, offering a scalable, secure solution that prioritizes patient autonomy and privacy in an increasingly digital healthcare landscape. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the association between the extent of nocturnal systolic blood pressure decline and left ventricular hypertrophy in patients with primary hypertension who were receiving antihypertensive drug therapy. Design: This was a cross-sectional hospital-based study from November 2020 to March 2021. Setting: The study was conducted at the Polyclinic of Korle Bu Teaching Hospital, Ghana. Participants: Outpatients ≥18 years old with primary hypertension who were receiving antihypertensive drug therapy. Interventions: Each participant underwent a 24-hour ambulatory blood pressure monitoring and a transthoracic echocardiogram. Main outcome measures: Left ventricular hypertrophy and the extent of mean systolic blood pressure decline during sleep. Results: 180 participants were recruited, comprising 110 (61.1%) females. The participants' mean (±SD) age was 57.6 ± 11.0 years. 80% had a non-dipping blood pressure pattern, and 43.9% had left ventricular hypertrophy. Uncontrolled office blood pressure was an independent predictor of left ventricular hypertrophy in these patients (AOR 2.010, 95% CI 1.048-3.855, p=0.036); however, a non-dipping nocturnal systolic blood pressure status was not (AOR 1.849, 95% CI 0.850-4.022, p=0.121). 61.1% had abnormal left ventricular geometry, with concentric hypertrophy being the predominant geometric pattern. Conclusion: Left ventricular hypertrophy and non-dipping nocturnal blood pressure were common in these hypertensive Ghanaian patients on antihypertensive therapy. Left ventricular hypertrophy was associated with uncontrolled office blood pressure but not the extent of nocturnal systolic blood pressure declines during a single 24-hour ambulatory blood pressure recording. [ABSTRACT FROM AUTHOR]

The exocyst complex, an evolutionarily conserved octameric protein assembly, plays a central role in the targeted binding and fusion of vesicles at the plasma membrane. In fungal cells, this transport system is essential for polarized growth, morphogenesis, cell wall maintenance and virulence. Recent advances have greatly improved our understanding of the role and regulation of the exocyst complex in fungi. This review synthesizes these developments and focuses on the intricate interplay between the exocyst complex, specific fungal cargos and regulatory proteins. Insights into thestructure of the exocyst and its functional dynamics have revealed new dimensions of its architecture and its interactions with the cellular environment. Furthermore, the regulation of exocyst activity involves complex signaling pathways and interactions with cytoskeletal elements that are crucial for its role in vesicle trafficking. By exploring these emerging themes, this review provides a comprehensive overview of the multifaceted functions of the exocyst complex in fungal biology. Understanding these mechanisms offers potential avenues for novel therapeutic strategies against fungal pathogens and insights into the general principles of vesicle trafficking in eukaryotic cells. The review therefore highlights the importance of the exocyst complex in maintaining cellular functions and its broader implications in fungal pathogenicity and cell biology. [ABSTRACT FROM AUTHOR]

Background and Aims: Impact of type 2 diabetes mellitus (T2DM) in patients with end-stage liver disease (ESLD) awaiting liver transplantation (LT) remains poorly defined. The objective of the present study is to evaluate the relationship between T2DM and clinical outcomes among patients with LT waitlist registrants. We hypothesize that the presence of T2DM will be associated with worse clinical outcomes. Methods: 593 patients adult (age 18 years or older) who were registered for LT between 1/2010 and 1/2017 were included in this retrospective analysis. The impact of T2DM on liver-associated clinical events (LACE), survival, hospitalizations, need for renal replacement therapy, and likelihood of receiving LT were evaluated over a 12-month period. LACE was defined as variceal hemorrhage, hepatic encephalopathy, and ascites. Kaplan–Meier and Cox regression analysis were used to determine the association between T2DM and clinical outcomes. Results: The baseline prevalence of T2DM was 32% (n = 191) and patients with T2DM were more likely to have esophageal varices (61% vs. 47%, p = 0.002) and history of variceal hemorrhage (23% vs. 16%, p = 0.03). The presence of T2DM was associated with increased risk of incident ascites (HR 1.91, 95% CI 1.11, 3.28, p = 0.019). Patients with T2DM were more likely to require hospitalizations (56% vs. 49%, p = 0.06), hospitalized with portal hypertension-related complications (22% vs. 14%; p = 0.026), and require renal replacement therapy during their hospitalization. Patients with T2DM were less likely to receive a LT (37% vs. 45%; p = 0.03). Regarding MELD labs, patients with T2DM had significantly lower bilirubin at each follow-up; however, no differences in INR and creatinine were noted. Conclusion: Patients with T2DM are at increased risk of clinical outcomes. This risk is not captured in MELD score, which may potentially negatively affect their likelihood of receiving LT. [ABSTRACT FROM AUTHOR]

This study simultaneously modelled the injury severity of motorcycle riders and their pillion passengers and determine the associated risk factors. The analysis is based on motorcycle crashes data in Ashanti region of Ghana spanning from 2017 to 2019. The study implemented bivariate ordered probit model to identify the possible risk factors under the premise that the injury severity of pillion passenger is endogenously related to that of the rider in the event of crash. The model provides more efficient estimates by considered the common unobserved factors shared between rider and pillion passenger. The result shows a significant positive relationship between the two injury severities with a correlation coefficient of 0.63. Thus, the unobservable factors that increase the probability of the rider to sustain more severe injury in the event of crash also increase that of their corresponding pillion passenger. The rider and their pillion passenger injury severities have different propensity to some of the risk factors including passengers' gender, day of week, road width and light condition. In addition, the study found that time of day, weather condition, collision type, and number of vehicles involved in the crash jointly influence the injury severity of both rider and pillion passenger significantly. [ABSTRACT FROM AUTHOR]

Low glycemic index (GI) diets have been recommended for the prevention and treatment of chronic diseases including diabetes, obesity, cancer and cardiovascular diseases. One of the high glycemic index diets consumed daily by many people around the world is the white bread, which is rich in carbohydrates. This study aimed at reducing the glycemic index of white bread by modifying the recipe with finger millet flour and to determine its effect on postprandial blood glucose response on Wister rats. Rats were grouped into five groups (n=5); group I normal control rats feed with white bread only (PC), group II fed with bread made from 15% finger millet composite flour (15%), group III fed with bread made from composite flour of 30% finger millet (30%), group IV fed with standard diabetic bread (commercially available) and group V rats were fed with standard commercial rat feed (NC). The rats were fasted overnight and fed with the bread samples. Blood glucose levels of all the rats were measured using glucometer by pricking the tail vein, at intervals of 0, 30, 60, 90 and 120 mins. From the result obtained, 30% showed lower postprandial blood glucose responses when compared to PC, 15% and NC group (p = 0.05) and the AUC result showed increased clearance of blood glucose in 30% group when compared with the PC, 15% and NC group. In conclusion, decreasing the glycemic index of white bread with finger millet composite flour can reduce postprandial blood glucose level and also increase the clearance of blood glucose from circulation. [ABSTRACT FROM AUTHOR]

Background: Patients living with life-limiting illnesses other than cancer constitute the majority of patients in need of palliative care globally, yet most previous systematic reviews of the cost impact of palliative care have not exclusively focused on this population. Reviews that tangentially looked at non-cancer patients found inconclusive evidence. Randomised controlled trials (RCTs) are the gold standard for treatment efficacy, while total health care costs offer a comprehensive measure of resource use. In the sole review of RCTs for non-cancer patients, palliative care reduced hospitalisations and emergency department visits but its effect on total health care costs was not assessed. The aim of this study is to review RCTs to determine the difference in costs between a palliative care approach and usual care in adult non-cancer patients with a life-limiting illness. Methods: A systematic review using a narrative synthesis approach. The protocol was registered with PROSPERO prospectively (no. CRD42020191082). Eight databases were searched: Medline, CINAHL, EconLit, EMBASE, TRIP database, NHS Evidence, Cochrane Library, and Web of Science from inception to January 2023. Inclusion criteria were: English or German; randomised controlled trials (RCTs); adult non-cancer patients (> 18 years); palliative care provision; a comparator group of standard or usual care. Quality of studies was assessed using Drummond's checklist for assessing economic evaluations. Results: Seven RCTs were included and examined the following diseases: neurological (3), heart failure (2), AIDS (1) and mixed (1). The majority (6/7) were home-based interventions. All studies were either cost-saving (3/7) or cost-neutral (4/7); and four had improved outcomes for patients or carers and three no change in outcomes. Conclusions: In a non-cancer population, this is the first systematic review of RCTs that has demonstrated a palliative care approach is cost-saving or at least cost-neutral. Cost savings are achieved without worsening outcomes for patients and carers. These findings lend support to calls to increase palliative care provision globally. [ABSTRACT FROM AUTHOR]

Automotive air conditioning (ACC) system designers faced unique challenges in satisfying customer demands for efficient and comfortable operation across a broad temperature range. The AAC system's effective or fixed temperature setting makes this possible. Many climate control models, like the state flow switching controller in MATLAB control, must handle heating and cooling due to a single Simulink/environment software and frequently contain steady-state error (SSE). The present research proposes to design an automatic temperature control scheme and fuzzy logic control (FLC) for an automotive air-conditioned (AAC) system. In addition, it employs MATLAB Simulink/environment software to model the fuzzy control technique to analyze the AAC system's response. A simulation has been set up to evaluate the suggested system performance to match a selection of user-specified reference temperatures and compressor speeds. Compared with a PID-controlled AAC system, the proposed FLC-based system reduced the undershoot to only 2.30% from 33.30% respectively, and was robust, quicker, and better at controlling temperature. • Challenges in automotive air conditioning systems for designers were addressed. • An automatic temperature control scheme was proposed via fuzzy logic control. • Improved efficiency and comfort in the AAC system was achieved. • The proposed FLC-based system reduced the undershoot to 2.30% from 33.30%. • The FLC-based was more robust, quicker, and better at controlling temperature. [ABSTRACT FROM AUTHOR]

The ability to power low-power devices and sensors has drawn a great deal of interest to energy harvesting from ambient vibrations. The application of variable-length pendulum systems in conjunction with piezoelectric or electromagnetic energy-harvesting devices is examined in this thorough analysis. Because of their changeable length, such pendulums may effectively convert mechanical vibrations into electrical energy. This study covers these energy-harvesting systems' basic theories, design concerns, modeling methods, and performance optimization strategies. This article reviews several studies that look at dynamic models, the effects of damping coefficients, device designs, and excitation parameters on energy output. The advantages and disadvantages of piezoelectric and electromagnetic coupling techniques are demonstrated by comparative research. This review also looks at technical advances and future research prospects in variable-length, pendulum-based energy harvesting. An expanded model for an energy harvester based on a variable-length pendulum derived from the modified, swinging Atwood machine is more specifically presented. This model's numerical simulations, estimated current and voltage outputs, and produced power from the electromagnetic and piezoelectric devices integrated at various points in a 4-DOF variable-length pendulum model all indicate encouraging results. This necessitates extra study, changes, and optimizations to improve the usefulness of the proposed model. Finally, important dynamic models on developing variable-length, pendulum-based energy harvesters for usage in a range of applications to create sustainable energy are summarized. [ABSTRACT FROM AUTHOR]

Why do urban development projects take a long time to complete? This question is of paramount importance, both practically and academically. Practically, understanding the reasons for delays in these projects can help improve project efficiency, reduce costs, and enhance stakeholder satisfaction. Academically, the study contributes to the field of urbanization by applying social network analysis (SNA) to explore the interactions and relationships among decision-makers in urban development projects. This study draws upon original data from a road extension project in Kristiansand to illustrate and explain why the implementation of large development projects suffers from convoluted and slow decision-making processes after an overall agreement on project aims and goals has been established. This study draws on a sample of 33 actors who participated in the decisions concerning the project. I collected the data through a combination of interviews and document reviews and subsequently analyzed them using social network structural metrics and visualization techniques. The results show that the actors are connected in less dense, more centralized, and clustered networks with subgroups and low reciprocity which have hampered efficient communication, resulting in delays. The findings imply that the pattern of relationships among decision-making actors can affect the amount of time taken to reach conclusions in urban development initiatives. [ABSTRACT FROM AUTHOR]

This article examines Ghana's land development and planning laws from a historical perspective. The methodology involves a documentary study of historical records to explore the evolution of these laws, spanning from the colonial period to the present. Through this approach it sheds light on significant milestones such as the 1988 local government changes, the land use decree's implementation by military juntas, and the identified deficiencies in the decree pertaining to physical planning. The expositions from this study show that Ghana has over the years adopted many land development and planning laws, that there is a visible demand for land among people and a desire by developers to use their land. The topic of planning is thus a significant area for stakeholders in Ghana. The study, therefore, recommends that, given the fact that land development and planning laws are here to stay, and that people are the primary drivers of social change, these laws should respect the culture and norms of the people, and should as well always incorporate active public engagement for stakeholders to feel a sense of ownership and belongingness in the entire process. [ABSTRACT FROM AUTHOR]

Cancer Disease remains a global health concern, demanding exploration into its causal factors for early detection and treatment. However, cancer data often presents a high-dimensional challenge for analysis. Selecting only relevant cancer genes can significantly enhance this analysis process. Traditional gene selection techniques such as heuristic methods have been employed over the years but proved infeasible. Thus, Swarm Intelligence algorithms known for their global search capabilities were developed. Nonetheless, the performance of these Swarm Intelligence algorithms is often influenced by their methods of initialization, affecting convergence, solution quality, and overall robustness. Chaos-based initialization methods have shown promise, yet their effectiveness remains underexplored in initializing SI algorithms. This research conducted a comprehensive performance comparison of three Swarm Intelligence algorithms: Particle Swarm Optimization, Salp Swarm Algorithm, and Firefly Algorithm. These algorithms were enhanced by incorporating the logistic chaotic map for initialization, specifically in the context of microarray cancer gene selection tasks. To assess the effectiveness of these enhanced algorithms, two cancer datasets were employed, namely Ovarian and Colon, and utilized two classifiers: the k-nearest neighbor and multilayer perceptron. The results of the study demonstrate that the logistic-chaos firefly algorithm paired with the k-nearest neighbor stands out as a significant performer, achieving an impressive overall accuracy rate of 93.95% while selecting 444 genes. In summary, the proposed logisticchaos firefly algorithm paired with the k-nearest neighbor approach proves itself as a worthy competitor in gene selection tasks. [ABSTRACT FROM AUTHOR]

In this study, a ratio-product-cum-exponential type estimators for estimating the population mean in single phase sampling were proposed. The biases and Mean Square Errors (MSEs) of these estimators were obtained up to the first order of approximation. Theoretical and empirical comparative approach using real datasets and simulation study were investigated. The results showed that the proposed estimators were more efficient than the sample mean, ratio, product, exponential ratio and product estimator. Furthermore, the efficiency of the proposed estimators were investigated at different correlation levels and it was found that as the correlation increases the efficiency also changes positively. This suggests that when the auxiliary and study variables are more strongly correlated, the estimators become more efficient, reducing estimation errors and increasing precision. [ABSTRACT FROM AUTHOR]

Efficiency analysis among maize farmers is crucial, especially when maize output continues to decline, even under improved technology. The aim of this study was to estimate the level of technical efficiency among maize farmers in Wa East District in Ghana and to assess the determinants of their technical efficiency. Data were collected from 273 household heads using the multistage sampling method. The study applied the stochastic translog production function to do the estimation and assessment. The results revealed a variation of 60.2%–89.5% efficiency levels among maize farmers. In addition, maize farmers achieved about 71.5% of the required technical competences. Factors contributing significantly were labour, land, age, farming experience, household size, hired labour and seed quality. The results showed an increasing returns-to-scale parameter being significantly different from unit. Recommendations are improvement in the capacity of farmers by agriculture extension service and accessibility of farmers to affordable production inputs in real time. [ABSTRACT FROM AUTHOR]

Background: Dignity is integral to palliative care. Illness can diminish it, causing hopelessness and the wish to hasten death. Yet, dignity is a complex multidimensional phenomenon, influenced by values and context. Understanding its varying interpretations can inform practice and policy. The aim of the study is to explore the understanding of dignity in adult patients with palliative care needs from a Lebanese perspective and how it is preserved during illness and while receiving health services. Design: Qualitative interview study underpinned with a social constructionist lens. Fourteen patients recruited from home-based hospice and outpatient clinics in Lebanon. Data analysed using reflexive thematic analysis. Results: Four themes were developed across all the interviews: (a) Dignity anchored through faith in God and religious practices; (b) Family support in maintaining physical, psychological wellbeing, and social connectedness; (c) Physical fitness, mental acuity, and healthy appearance through which patients may escape the stigma of disease, (d) accessible, equitable, and compassionate healthcare. Discussion: Dignity is elusive and difficult to define but faith and religious beliefs play a significant contribution in this study. For the participants, illness is seen as a natural part of life that does not necessarily diminish dignity, but it is the illness related changes that potentially affect dignity. Findings show the importance of family and children in preserving dignity during illness and how their active presence provide a sense of pride and identity. Participants aspired to restore physical, social, and mental well-being to reclaim their dignity and normalize their lives. Challenges related to physical appearance, memory loss, vitality, and social stigma associated with illness diminished dignity. Accessible, equitable and compassionate healthcare services are also crucial in preserving dignity. Participants valued clear communication, respect, and empathy from healthcare providers and identified affordability of care essential for maintaining dignity. Conclusion: Faith in God, and strong family ties are dominant elements to maintaining dignity in the Lebanese context. Relational connectedness with family, children or God is also a need in maintaining dignity in other communal countries with variations in emphasis. The study indicates that religious and cultural context shapes the needs and perceptions of dignity during illness. These findings are likely to be transferable to many Middle Eastern countries but also countries with strong religious and family ties globally. [ABSTRACT FROM AUTHOR]

The aetiology of mechanical bowel obstruction exhibits significant variability based on geographical location and age. In high-income countries, postoperative adhesions and hernias are frequently cited as the primary causes, whereas in low- and middle-income countries (LMCIs), hernias take precedence. Speculation exists within the surgical community regarding whether this trend has evolved in LMCIs. To address this knowledge gap, our study aims to conduct a systematic review of existing literature, focusing on understanding the most prevalent causes of mechanical bowel obstruction in both pediatric and adult populations within LMCIs, providing valuable insights for surgical practice. This protocol was designed and written according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol 2015 (PRISMA-P 2015) statement. However, the results of the systematic review will be reported following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. We will consider studies published in English and French between 2002 and 2022 that reported on the aetiology of mechanical bowel obstruction in any age group in low- and middle-income countries. We will conduct a literature search using Ovid MEDLINE, Ovid Embase, CINAHL on EBSCO and Web of Science databases employing relevant subject headings, keywords and synonyms, which will be combined using Boolean operators to refine the search results. A hand search of references of retrieved literature will be conducted. The retrieved articles will be imported into Zotero for de-duplication. The resulting set of titles and abstracts will be uploaded to Rayyan (an AI-assisted online systematic review tool), where they will be double-checked to identify articles eligible for inclusion. Two independent reviewers will screen articles to be included and disagreement will be resolved by discussion or by a third reviewer as a tie-breaker. Also, data extraction will be done by one reviewer and confirmed by another. Critical appraisal to assess the quality of the included studies will be carried out by two independent reviewers using the Joanna Briggs Institute (JBI) tools. We anticipate that the eligible studies will be quite heterogeneous in terms of their design, outcomes of interest, populations and comorbidities. Therefore, resmay be synthesised descriptively without meta-analysis using charts, graphs and tables. Where possible, we will conduct a sub-analysis using conceptual frameworks based on age, WHO regions and continents. [ABSTRACT FROM AUTHOR]

Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes. [ABSTRACT FROM AUTHOR]

Aims To examine the cross sectional and longitudinal associations between the Alcohol Use Disorders Identification Test-Concise (AUDIT-C) and differences in high-density lipoprotein (HDL) in a psychiatrically ill population. Methods Retrospective observational study using electronic health record data from a large healthcare system, of patients hospitalized for a mental health/substance use disorder (MH/SUD) from 1 July 2016 to 31 May 2023, who had a proximal AUDIT-C and HDL (N  = 15 915) and the subset who had a repeat AUDIT-C and HDL 1 year later (N  = 2915). Linear regression models examined the association between cross-sectional and longitudinal AUDIT-C scores and HDL, adjusting for demographic and clinical characteristics that affect HDL. Results Compared with AUDIT-C score = 0, HDL was higher among patients with greater AUDIT-C severity (e.g. moderate AUDIT-C score = 8.70[7.65, 9.75] mg/dl; severe AUDIT-C score = 13.02 [12.13, 13.90] mg/dL[95% confidence interval (CI)] mg/dl). The associations between cross-sectional HDL and AUDIT-C scores were similar with and without adjusting for patient demographic and clinical characteristics. HDL levels increased for patients with mild alcohol use at baseline and moderate or severe alcohol use at follow-up (15.06[2.77, 27.69] and 19.58[2.77, 36.39] mg/dL[95%CI] increase for moderate and severe, respectively). Conclusions HDL levels correlate with AUDIT-C scores among patients with MH/SUD. Longitudinally, there were some (but not consistent) increases in HDL associated with increases in AUDIT-C. The increases were within range of typical year-to-year variation in HDL across the population independent of alcohol use, limiting the ability to use HDL as a longitudinal clinical indicator for alcohol use in routine care. [ABSTRACT FROM AUTHOR]

This paper introduces a novel approach for solving first-order stiff initial value problems through the development of a one-step family of three optimized second-derivative hybrid block methods. The optimization process was integrated into the derivation of the methods to achieve maximal accuracy. Through a rigorous analysis, it was determined that the methods exhibit properties of consistency, zero-stability, convergence, and A-stability. The proposed methods were implemented using the waveform relaxation technique, and the computed results demonstrated the superiority of these schemes over certain existing methods investigated in the study. [ABSTRACT FROM AUTHOR]

This research investigates the extraction of biomass-derived reducing sugars from sugarcane bagasse and their dehydration to fatty acids. The fatty acids were esterified to bioactive fatty acid esters using a catalyst. The contents of the active extracts were analyzed by spectroscopic methods (FT-IR, TGA, ED-XRF, and GC-MS). Applying in silico molecular modeling study, the compounds' possible bioactivity was examined. The compounds were explored for their hepatoprotective potential against selected targets: TNFa (PDB ID: 6MKB), TNF receptor (PDB ID: 1XU2), and GSH reductase (PDB ID: 2LV3). From the results of the docking analysis, compound A was identified to have a binding energy of - 6.4 kcal/mol, -5.4 kcal/mol, and -4.8 kcal/mol against the target proteins respectively. Assessed for their drug-likeness and bioavailability, all compounds were found to follow the Lipinski rule of five, Ghose, Veber, Egan, and Muegge criteria. None of the molecules violated more than one of Lipinski's rules of five. In this regard, the compounds showed good drug-likeness and pharmacokinetic scores, suggesting their potential to be highly bioavailable and active oral drugs with low toxicity. Based on the results, it can be concluded that the bioactive compounds can be used as hepatoprotective agents. [ABSTRACT FROM AUTHOR]

Gold nanoparticles (AuNPs) are arguably the most promising in terms of application among the noble metal nanoparticles. As such, researchers have dedicated a considerable amount of energy towards the synthesis of novel gold nanoparticles with different morphology and size, which in turn affect its potential application. This study synthesized novel spherical-shaped AuNPs via green reduction of gold ion in an aqueous solution of HAuCl4.3H2O in the presence of trimethyl chitosan as a stabilizing agent and pressurized H2 gas as a reducing agent on an ice water. The size, morphology, chemical composition, chemical environment and optical activities were examined by scanning electron microscope (SEM), high-resolution transmission electron microscope (HRTEM), x-ray photoelectron spectroscopy (XPS), and ultraviolet–visible spectroscopy (Uv–Visible), respectively. The average particle size of AuNPs is 37 nm while HR-TEM revealed a unique spherical morphology. The Tauc’s plot calculation revealed a band gap of 5.0 eV. This unique morphology and optical local field enhancement in plasmonic nanocomposites could be suitable alternative for conducting devices and photocatalysis. [ABSTRACT FROM AUTHOR]

Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. [ABSTRACT FROM AUTHOR]

To improve their properties or to introduce entirely new functionalities, the intriguing scaffolds of nucleic acids have been decorated with various modifications, most recently also organometallic ones. While challenging to introduce, organometallic modifications offer the potential of expanding the field of application of metal-dependent functionalities to metal-deficient conditions, notably those of biological media. So far, organometallic moieties have been utilized as probes, labels and catalysts. This Feature Article summarizes recent efforts and predicts likely future developments in each of these lines of research. [ABSTRACT FROM AUTHOR]

The challenge facing Helicobacter pylori (H. pylori) infection management in some parts of Africa is the evolution of drug-resistant species, the lack of gold standard in diagnostic methods, and the ineffectiveness of current vaccines against the bacteria. It is being established that even though clinical consequences linked to the bacteria vary geographically, there is rather a generic approach to treatment. This situation has remained problematic in the successful fight against the bacteria in parts of Africa. As a result, this study compared the genomes of selected H. pylori isolates from selected areas of Africa and evaluated their virulence and antibiotic drug resistance, those that are highly pathogenic and are associated with specific clinical outcomes and those that are less virulent and rarely associated with clinical outcomes. 146 genomes of H. pylori isolated from selected locations of Africa were sampled, and bioinformatic tools such as Abricate, CARD RGI, MLST, Prokka, Roary, Phandango, Google Sheets, and iTOLS were used to compare the isolates and their antibiotic resistance or susceptibility. Over 20 k virulence and AMR genes were observed. About 95% of the isolates were genetically diverse, 90% of the isolates harbored shell genes, and 50% harbored cloud and core genes. Some isolates did not retain the cagA and vacA genes. Clarithromycin, metronidazole, amoxicillin, and tinidazole were resistant to most AMR genes (vacA, cagA, oip, and bab). Conclusion. This study found both virulence and AMR genes in all H. pylori strains in all the selected geographies around Africa with differing quantities. MLST, Pangenome, and ORF analyses showed disparities among the isolates. This in general could imply diversities in terms of genetics, evolution, and protein production. Therefore, generic administration of antibiotics such as clarithromycin, amoxicillin, and erythromycin as treatment methods in the African subregion could be contributing to the spread of the bacterium's antibiotic resistance. [ABSTRACT FROM AUTHOR]

Geo-polymer concrete has a significant influence on the environmental condition and thus its use in the civil industry leads to a decrease in carbon dioxide (CO2) emission. However, problems lie with its mixed design and casting in the field. This study utilizes supervised artificial-based machine learning algorithms (MLAs) to anticipate the mechanical characteristic of fly ash/slag-based geopolymer concrete (FASBGPC) by utilizing AdaBoost and Bagging on MLPNN to make an ensemble model with 156 data points. The data consist of GGBS (kg/m3), Alkaline activator (kg/m3), Fly ash (kg/m3), SP dosage (kg/m3), NaOH Molarity, Aggregate (kg/m3), Temperature (°C) and compressive strength as output parameter. Python programming is utilized in Anaconda Navigator using Spyder version 5.0 to predict the mechanical response. Statistical measures and validation of data are done by splitting the dataset into 80/20 percent and K-Fold CV is employed to check the accurateness of the model by using MAE, RMSE, and R2. Statistical analysis relies on errors, and tests against external indicators help determine how well models function in terms of robustness. The most important factor in compressive strength measurements is examined using permutation characteristics. The result reveals that ANN with AdaBoost is outclassed by giving maximum enhancement with R2 = 0.914 and shows the least error with statistical and external validations. Shapley analysis shows that GGBS, NaOH Molarity, and temperature are the most influential parameter that has significant content in making FASBGPC. Thus, ensemble methods are suitable for constructing prediction models because of their strong and reliable performance. Furthermore, the graphical user interface (GUI) is generated through the process of training a model that forecasts the desired outcome values when the corresponding inputs are provided. It streamlines the process and provides a useful tool for applying the model's abilities in the field of civil engineering. [ABSTRACT FROM AUTHOR]

AbstractA robust, accurate and reliable approach is essential for not only examining people’s acceptance of cloud-based learning management systems in developing nations but also for accurate prediction of factors affecting its implementation and progress. Therefore, in this study, three different soft computing models; Adaptive neuro-fuzzy inference system (ANFIS), Support vector regression (SVR), and Emotional artificial neural network (EANN), were employed for predictions of factors affecting cloud-based learning management systems take-up and progress using data gotten from six Nigerian colleges. The performance of the models was assessed using five arithmetic metrics; MAPE, NSE, RMSE, rRMSE, and RM. All the proposed models forecast the effects of the study inputs on LMS with higher accuracy (NSE > 0.98). However, the SVR model outshone the other models as it increased the performance of the study-reported model by 2% and 4% respectively. Based on the study results, instructors’ quality, motivation, and resource availability were found to be the key factors that affect cloud-based learning technologies take-up and progress in the study area. Interestingly, unlike prior studies, this study found system ease of use and usefulness to have insignificant effects on LMS take-up. Finally, the practical implications and limitations of the study were discussed based on the study findings. [ABSTRACT FROM AUTHOR]

Background: The majority of published literature clinically assesses surgical outcomes after lower limb replantation for traumatic amputations. However, patients' satisfaction and quality of life may not be accurately measured through rigid scoring using standardized patient reported outcome measures. Purpose: The aim of this study was to qualitatively assess patient satisfaction and factors associated with achieving good outcomes after successful lower limb replantation surgery. Methods: A semi-structured interview was conducted with 12 patients who underwent lower limb replantation surgery following traumatic amputation injuries. The interview focused on the patients' experience and satisfaction throughout their injury, surgical journey, rehabilitation and reintegration into their communities. An inductive and deductive thematic analysis was applied using the recorded transcripts to evaluate the overall satisfaction of the patients after lower limb replantation surgery. Results: The following observations emerged from the structured themes among all the patients interviewed: (1) Family and social support was significantly associated with improved qualities of life and satisfaction after lower limb replantation; (2) Patients were generally satisfied with their outcomes despite limitations in physical capabilities; (3) Satisfaction was associated with acceptance of their cosmetic deformity; (4) Social integration and being able to participate in a meaningful manner was associated with greater satisfaction after recovery. Conclusions: Patients who undergo lower limb replantation can have a significantly improved quality of life if they have strong social support, are able to contribute in a meaningful manner to their communities after surgery, and are accepting of their cosmetic deficiencies. [ABSTRACT FROM AUTHOR]

Viscoelastic composites are widely used in engineering applications, necessitating a comprehensive understanding of their effective response to external loads. This study employs peridynamic computational homogenization theory to investigate the influence of phase contrast and inclusion shape on the effective properties of these composites. By focusing on a two-phase matrix-inclusion composite material and considering circular and elliptical inclusion shapes, this study explores the relationship between these factors and the resulting effective behavior. The simulation results demonstrate that the use of circular inclusions result in isotropic effective response of the composites for all values of phase contrasts, while elliptical inclusions lead to an increase in anisotropy as phase contrast increases. These findings highlight the significant impact of inclusion shape and phase contrast on the effective behavior of composites. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to inspect the unsteady MHD mixed convective Couette flow of viscous dissipative fluid in a vertical channel filled with porous material. The steady state analytical solutions of temperature, velocity, frictional force and heat transfer rate are obtained using the Homotopy perturbation method (HPM). The implicit finite difference technique is used to solve the transient leading equations numerically. Plots and tables with the dynamic flow parameters and dimensionless variables are displayed. During this computation, it was found that raising the Darcy parameter (Da) and the mixed convection (Gre) parameters both push the fluid flow upwards, but increasing the magnetic field's values had the opposite effect (M). [ABSTRACT FROM AUTHOR]

Background: Although the treatment for end-stage renal disease (ESRD) under Nigeria's National Health Insurance Authority is haemodialysis (HD), the cost of managing ESRD is understudied in Nigeria. Therefore, this study estimated the provider and patient direct costs of haemodialysis and managing ESRD in Abuja, Nigeria. Method: The study was a cross-sectional survey from both healthcare provider and consumer perspectives. We collected data from public and private tertiary hospitals (n = 6) and ESRD patients (n = 230) receiving haemodialysis in the selected hospitals. We estimated the direct providers' costs using fixed and variable costs. Patients' direct costs included drugs, laboratory services, transportation, feeding, and comorbidities. Additionally, data on the sociodemographic and clinical characteristics of patients were collected. The costs were summarized in descriptive statistics using means and percentages. A generalized linear model (gamma with log link) was used to predict the patient characteristics associated with patients' cost of haemodialysis. Results: The mean direct cost of haemodialysis was $152.20 per session (providers: $123.69; and patients: $28.51) and $23,742.96 annually (providers: $19,295.64; and patients: $4,447.32). Additionally, patients spent an average of $2,968.23 managing comorbidities. The drivers of providers' haemodialysis costs were personnel and supplies. Residing in other towns (HD:β = 0.55, ρ = 0.001; ESRD:β = 0.59, ρ = 0.004), lacking health insurance (HD:β = 0.24, ρ = 0.038), attending private health facility (HD:β = 0.46, ρ < 0.001; ESRD: β = 0.75, ρ < 0.001), and greater than six haemodialysis sessions per month (HD:β = 0.79, ρ < 0.001; ESRD: β = 0.99, ρ < 0.001) significantly increased the patient's out-of-pocket spending on haemodialysis and ESRD. Conclusion: The costs of haemodialysis and managing ESRD patients are high. Providing public subsidies for dialysis and expanding social health insurance coverage for ESRD patients might reduce the costs. [ABSTRACT FROM AUTHOR]

The rising prevalence of multidrug-resistant (MDR) and extended-spectrum beta lactamase-resistant (ESBL) Klebsiella pneumoniae (K. pneumoniae) is an important global public health challenge. This threat is even more pertinent in clinical settings. Morbidity and mortality associated with this condition are alarming particularly in the developing regions of the world. A comprehensive evaluation of the epidemiology of this phenomenon will assist towards the global effort of reducing its burden. So, this systematic review and meta-analysis was conducted to evaluate the epidemiology of MDR K. pneumoniae in South-Eastern Asia (SEA). The study was done under the PRISMA guidelines and was preceded by the development of a priori protocol. The protocol was then registered in PROSPERO—the public registry for systematic reviews. Seven important outcomes which include the assessment of the overall MDR K. pneumoniae prevalence were designed to be evaluated. A literature search was carried out in five selected electronic databases and 4389 were screened. Of these articles, 21 studies that met the eligibility criteria were included in the review. Relevant data were extracted from the included studies. By conducting a quality effect meta-analysis, the pooled prevalence for MDR and ESBL K. pneumoniae in SEA was estimated at 55% (CI 9–96) and 27% (CI 32–100) respectively. The review also identified ESBL genes types of allodemic situations occurring mostly in respiratory tract infections. The high prevalence of MDR and ESBL K. pneumoniae in this subregion is highly significant and of both public health and clinical relevance. Overall, the findings of this review will assist in the effective prevention and control of this threat in SEA. [ABSTRACT FROM AUTHOR]

Objective: To examine the smoking patterns of women who experienced stressful life events and the impact of racial disparities on the relationship between stressful life events, and prenatal/ postpartum smoking. Methods: The study analyzed data from the Pregnancy Risk Assessment Monitoring System Phase 8 (2016–2018) survey across five states (CT, LA, MA, MO, WI). Four stressful life event categories were created using thirteen affiliated questions: financial, trauma, partner, and emotional. We assessed: 1) the association between smoking and stressful life events, 2) the impact of race on the relation between smoking and stressful life events, and 3) the long-term effects of smoking on health by assessing the association between smoking and maternal morbidity. Bivariate statistics and multivariate Poisson regression models were conducted. Results: A total of 24,209 women from five states were included. 8.9% of respondents reported smoking during pregnancy, and 12.7% reported smoking postpartum. There was a significant association between all stressful life events and smoking. Trauma stressful life event had the strongest association with smoking during pregnancy (adjusted PR=2.01; CI: 1.79-2.27) and postpartum (adjusted PR= 1.80; CI: 1.64-1.98). Race and stressful life event interaction effects on smoking had varied significant findings, but at least one racial/ ethnic minority group (Black, Hispanic, Asian) had a higher smoking prevalence than non-Hispanic White per stressful life event category. Lastly, the prevalence of maternal morbidity was higher for smoking during pregnancy (adjusted PR= 1.28; CI: 1.19-1.38) and postpartum (adjusted PR= 1.30; CI: 1.22-1.38) compared to no smoking. Conclusions for Practice: Culturally congruent, multi-disciplinary care teams are needed to address both clinical and social needs to reduce stressful life events and smoking. Screenings for stress should be standardized with a referral system in place to provide ongoing support. [ABSTRACT FROM AUTHOR]

Worldwide, the recent SARS-CoV-2 virus disease outbreak has infected more than 691,000,000 people and killed more than 6,900,000. Surprisingly, Sub-Saharan Africa has suffered the least from the SARS-CoV-2 pandemic. Factors that are inherent to developing countries and that contrast with their counterparts in developed countries have been associated with these disease burden differences. In this paper, we developed data-driven COVID-19 mathematical models of two 'extreme': Cameroon, a developing country, and New York State (NYS) located in a developed country. We then identified critical parameters that could be used to explain the lower-than-expected COVID-19 disease burden in Cameroon versus NYS and to help mitigate future major disease outbreaks. Through the introduction of a 'disease burden' function, we found that COVID-19 could have been much more severe in Cameroon than in NYS if the vaccination rate had remained very low in Cameroon and the pandemic had not ended. [ABSTRACT FROM AUTHOR]

Background: Exclusive breastfeeding is a public health priority in sub-Saharan Africa. However, systematic reviews on its determinants in Ghana remain scarce. Therefore, we systematically reviewed the prevalence and determinants of exclusive breastfeeding in children 0–6 months in Ghana. Methods: We conducted systematic searches in Embase, Medline, and Africa-Wide Information from the databases' inception until February 2021 for studies that assessed the prevalence and determinants of exclusive breastfeeding in children 0–6 months in Ghana. Random-effects meta-analysis was used to estimate the pooled prevalence of exclusive breastfeeding and narrative synthesis to summarise the determinants. We calculated the proportion of total variability that was due to between study heterogeneity using I² statistics, and Egger's test assessed publication bias. The review is registered with PROSPERO, CRD42021278019. Results: Out of the 258 articles identified, 24 met the inclusion criteria. Most of the included studies were cross-sectional and were published between 2005 and 2021. The pooled prevalence of exclusive breastfeeding (EBF) among children 0–6 months in Ghana was 50% (95%CI 41.0–60.0%). The prevalence was higher in rural areas (54%) than in urban areas (44%). Several factors were identified as facilitators of EBF, including older maternal age, self-employment, unemployment, living in a large house, being a house owner, giving birth in a health facility, non-caesarean delivery, adequate antenatal attendance, counselling services, participation in support groups, adequate knowledge about EBF, positive attitude towards EBF, and higher maternal education among rural dwellers. Additionally, having an average birthweight facilitated EBF. Barriers to EBF were also identified, including higher maternal education among urban dwellers, less than three months of maternity leave, maternal HIV-positive status, the experience of partner violence, lack of access to radio, inadequate breastmilk production, lack of family support, having a partner who wants more children, counselling on complementary feeding, healthcare worker recommendation of complementary feed, single marital status, and infant admission to neonatal intensive care units. Conclusion: In Ghana, EBF rates are low, with only about half of all children aged 0–6 months breastfed exclusively. A multi-dimensional approach is required to tackle the diverse sociodemographic, obstetric, and infant-related issues that hinder EBF practice in Ghana. [ABSTRACT FROM AUTHOR]

Cyberphysical systems connect physical devices and large private network environments in modern communication systems. A fundamental worry in the establishment of large private networks is mitigating the danger of transactional data privacy breaches caused by adversaries using a variety of exploitation techniques. This study presents a privacy-preserving architecture for ensuring the privacy and security of transaction data in large private networks. The proposed model employs digital certificates, RSA-based public key infrastructure, and the blockchain to address user transactional data privacy concerns. The model also guarantees that data in transit remains secure and unaltered and that its provenance remains authentic and secure during node-to-node interactions within a large private network. The proposed model has increased the encryption speed by about 17 times, while the decryption process is expedited by 4 times. Therefore, the average overall acceleration obtained was 16.5. Both the findings of the security analysis and the performance analysis demonstrate that the proposed model can safeguard transactional data during communications on large private networks more effectively and securely than the existing solutions. [ABSTRACT FROM AUTHOR]

A brand-new vanadium pentoxide (V2O5) functionalized starch (St) grafted poly(acrylonitrile) (PAN) adsorbent was synthesized via microwave-assisted graft polymerization method to remove methylene blue dye from water. FTIR, TEM, SEM, and XRD analysis were used to characterize the materials. Experiments on batch adsorption were conducted on the V2O5 and V2O5-St-g-PAN composite. The most significant removal efficiency of methylene blue (MB) by V2O5-St-g-PAN in water was 90% at a pH of 9 with an optimum adsorbent dose of 0.2 g in a 50 mL of 50 mg/mL MB concentration. The adsorption mechanism followed the Langmuir isotherm model with a correlation coefficient (R2) of 0.9996. The adsorption of MB onto V2O5-St-g-PAN was thermodynamically favorable at all temperatures (ΔGo = −56.371 KJ/mol to −56.164 KJ/mol). A negative enthalpy change (ΔHo) of −60.482 KJ/mol and a positive entropy change (ΔSo) of +0.0138 KJ/mol indicates an exothermic and highly ordered adsorption process. [ABSTRACT FROM AUTHOR]

There are indications that gender has an effect on individual risk factors and pathways to HIV diagnoses and treatment. Furthermore, there is growing recognition that to improve HIV-related health outcomes for men, it is important to understand their experiences and perspectives. Perhaps because of the physical nature of construction work, the South African construction industry is dominated by men. Given that employed men are a hard-to-reach community population group, the construction workplace offers an ideal environment for data collection and delivery of non-health-facility-based HIV prevention and treatment interventions. Furthermore, workers in the construction industry have been identified as being at a heightened risk of acquiring HIV and AIDS because of work-related travel, the ubiquity of transactional sex around worker hostels and having an increased likelihood of multiple and concurrent sex partnerships. As a consequence, this study examines the association between condom use and sexual partnerships among men working in the construction industry. A purposive cross-sectional survey was used to collect data from 450 workers across 18 construction sites in the Western Cape province of South Africa. The types of sexual partnership had three categories: regular sex partnerships, casual sex partnerships and sex worker partnerships. Frequency of condom use was determined to be highest with casual sex partners (51.2%), followed by sex workers (40.6%) and regular sex partners (25.6%). Hierarchical multiple linear regression analysis was used to examine the demographic, experiential, behavioural and cognitive predictors of condom use across the three categories of sexual partnership. The results indicate that an individual's perception of control over condom use, and the perceived threat posed by HIV and AIDS are significantly associated with consistent condom use, even after accounting for differences in partner type. Implications of the findings are discussed, and directions for future research on the association between sexual partnerships and condom use are offered. [ABSTRACT FROM AUTHOR]

Cyberphysical systems connect physical devices and large private network environments in modern communication systems. A fundamental worry in the establishment of large private networks is mitigating the danger of transactional data privacy breaches caused by adversaries using a variety of exploitation techniques. This study presents a privacy-preserving architecture for ensuring the privacy and security of transaction data in large private networks. The proposed model employs digital certificates, RSA-based public key infrastructure, and the blockchain to address user transactional data privacy concerns. The model also guarantees that data in transit remains secure and unaltered and that its provenance remains authentic and secure during node-to-node interactions within a large private network. The proposed model has increased the encryption speed by about 17 times, while the decryption process is expedited by 4 times. Therefore, the average overall acceleration obtained was 16.5. Both the findings of the security analysis and the performance analysis demonstrate that the proposed model can safeguard transactional data during communications on large private networks more effectively and securely than the existing solutions. [ABSTRACT FROM AUTHOR]

The study looked into the use of input in sesame production with the view on seeing the returns to its production in Ringim Local Government Area, Jigawa State, Nigeria. Data were obtained from 100 randomly selected farmers using the multistage sampling technique. Descriptive statistics, net farm income and regression model were used in data analysis. The result showed that the mean age of the respondents was 38 years with secondary education been most popularly attained. The respondents had a household size of 3 persons cultivating a farm size of 3.5ha with experience of 8 years on average in sesame production. The results also reveal net farm income and return on naira invested of N 46,190.59 and 1.54 respectively, an indication of a profitable enterprise. The semi-log functional form gave the best fit based on the normal econometric criteria with coefficient of multiple determination of 0.312 implying that about 31 percent of the variation in yield of sesame was explained by the specified explanatory variables. It also revealed that there was under utilization of all the production inputs under consideration. It is therefore encouraged that more of the limiting factors (farm size, quantity of seed and quantity of organic manure) observed be put into cultivation. [ABSTRACT FROM AUTHOR]

The need for clean and renewable energy resources is increasing day by day. One of the most important of these resources is hydrogen, known as green energy. The most environmentally friendly method among hydrogen production processes is the electrolysis, in which pure hydrogen is obtained without any separation and purification processes. Carbon emissions is zero during production. The disadvantage of this method is that the production costs are high. For this reason, this study is aimed at improving a cathode material, which play a major role in the efficiency of electrolyzers. Electrochemically Ni, hydrothermally CoW and CoIr nanoparticles modified graphite electrodes are prepared as hydrogen evolution catalysts. The hydrothermally synthesized nanoparticles are impregnated on Ni-deposited graphite. The hydrogen evolution reaction activity of the prepared electrodes was investigated by electrochemical techniques. The cyclic voltammetry, linear sweep voltammetry, potentiodynamic polarization, and electrochemical impedance spectroscopy techniques performed the electrochemical analyzes. The surface morphology and chemical composition of the synthesized nanoparticles were investigated using scanning electron microscopy, Energy-Dispersive X-ray spectroscopy and X-ray diffraction techniques. The catalytic efficiency is near for C/NiCoIr, and C/NiCoW electrodes, which has hydrogen volume of 108 and 105 mL cm−2 h−1 by electrolysis of water. [Display omitted] • C rod was prepared with Ni, CoW, and CoIr metals to investigate HER efficiency. • The C/NiCoW and C/NiCoIr nanoparticles were synthesized by hydrothermal method. • The catalyst efficiency for H 2 evolution was responsible for the synergistic effect. • The catalyst was exhibited excellent HER activity and high stability. [ABSTRACT FROM AUTHOR]

Introduction: The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is due to presence of the blaNDM-1 gene that expresses the NDM-1 enzyme. As antibiotic resistance is a threat to public health, it is important to determine the prevalence of CRKP isolated from patients at a teaching hospital in the east coast of Peninsular Malaysia and understand the demographical trend of the bacteria in patients to keep infection at bay. Methods: A total of 213 Klebsiella pneumoniae isolates from the year 2017 to 2019, of non-repetitive clinical specimens of patients were tested for sensitivity against carbapenems using the disc-diffusion method. Phenotypic detection of carbapenemase was performed using the modified Hodge test and polymerase chain reaction was used to detect the presence of blaNDM-1 from bacterial DNA. Results: Isolates with blaNDM-1 gene was present in 93.4% (n=199) of 213 samples, with the highest number in blood (20.7%, n=44) and urine samples (20.7%, n=44). CRKP isolates producing NDM-1 enzyme were found to be the highest in male patients (56.8%, n=113) and in those aged between 61 and 80 years (49.7%, n=99), although it was not significantly associated. Conclusion: This study identified the presence of blaNDM-1 in a large proportion of CRKP isolates obtained from samples at the teaching hospital. This may require the formulation of protocols to screen for CRKP and reduce the risk of infection, especially among elderly males. The Ministry of Health may need to implement screening protocols to reduce infection risk. [ABSTRACT FROM AUTHOR]

Vector control remains the preferred method for effective malaria control. The impressive results of vector control are however, threatened by emerging resistance to insecticides among Anopheles gambiae s.l. mosquitoes. This study aimed at determining the pattern of resistance to selected insecticides in each class of carbamates, organochlorines, organophosphates, and pyrethriods using World Health Organisation tubes and Centre for Disease prevention and Control standard bottle assay protocols. Larvae and pupae of Anopheles mosquitoes were collected in villages of Buruku and Katsina-Ala Local Government Areas of Benue State between April and May 2019 and reared at 27oC and 80% relative humidity to adults at the Nasarawa state University Insectary. Susceptibility tests were carried out on 2-3 days old non-blood fed female adults. With WHO test method, Anopheles mosquitoes were completely susceptible (100% mortality) to Primiphos-methyl (organophosphate), Lambdacyhalothrin (pyrethroids) in Buruku and Katsina Ala but were resistant (54% mortality) to DDT (Organochlorine) in both sites. Mosquitoes were resistant (88% mortality) to Bendiocarb (Carbamates) in Katsina Ala but susceptible in Buruku with 99% mortality. However, the results for CDC bottle bioassays showed that Anopheles mosquitoes were susceptible to Primiphos methyl, Lambdacyhalothrin and Bendiocarb (>98% mortality) except for DDT which was resistant (<85% mortality) in both LGAs. Overall, this study shows that Anopheles gambiae s.l are resistant to DDT. The resistance may have arisen from indiscriminate use of the pesticide in households and for agricultural purposes. This study provides baseline and useful information on the susceptibility status of Anopheles mosquito populations to four classes of insecticides approved for public health use. Proper regulation should therefore be put in place on the procurement and use of this insecticide. [ABSTRACT FROM AUTHOR]

Introduction: Terminalia catappa (T. catappa) leaves are used in the treatment of hypertension, diabetes, cough, jaundice, indigestion etc, while the bark is used to treat diarrhea, dysentery, abscesses etc. Due to the acceptance and increased use of medicinal plants in pregnancy, there is a need to evaluate their toxicological profiles in pregnancy for safe use. This study aims to evaluate the toxicological effects of aqueous leaf extract of T. catappa in pregnant rats. Methods: acute toxicity study was carried out using Organization of Economic Corporation Development (OECD) 423 guidelines. Seventy-five rats (50 females and 25 males) were used at the age of 2 weeks just after weaning. The male rats were separated from the female rats in different cages and allowed to mature for 10 weeks. Then the rats were allowed to mate. After mating, 20 female rats with viable spermatozoa counts were selected and divided into 4 groups of 5 rats each (n=5). The control group received distilled water while the treatment groups II, III, and IV were administered with aqueous leaf extract of T. catappa orally at graded doses of 100, 200, and 400 mg/kg respectively for 21 consecutive days. The daily food and water intake, and weight were recorded. On the 22th day, the rats were anesthetized by chloroform inhalation, and blood samples were collected for haematological and biochemical analysis. The maternal livers, kidneys, and hearts were collected and weighed, and histological studies were carried out. The fetuses were removed and examined. An isolated tissue experiment was carried out on the myometrium of the pregnant rat uterus. The isometric reading of the uterine contractions was recorded. Results: the oral LD50 was found to be ≤2000-5000 mg/kg. There was a significant (p<0.05) increase in the mean food intake at the 100, 200, and 400 mg/kg doses of the extract used on the 14th and 21st days when compared to the 7th day. The renal function test showed a significant (p<0.05) increase for chloride. The liver function test revealed that the extract at 100 mg/kg dose, significantly (p<0.05) increased only Alkaline Phosphatase (ALP) liver enzyme, while at 200 mg/kg dose, only AST liver enzyme was significantly (p<0.05) increased, while at 400 mg/kg dose, ALT, AST, ALP, and albumin increased significantly (p<0.05) when compared to the control group. There was a significant (p<0.05) decrease in the relative organ weight of the liver at 400 mg/kg dose of the extract. The liver histology showed moderate hepatic vacuolation and necrosis, while the histology of the kidney showed slight tubular necrosis. Conclusion: this study has shown that the aqueous leaf extract of T. catappa is relatively not safe in the pregnant rats. Although it is non-toxic to the fetus, it exhibited tocolytic effect by inhibiting uterine contractions, thus it should be used with caution during pregnancy, especially in the third trimester or during labor. [ABSTRACT FROM AUTHOR]