1. Fallacies of a purely virtual platform: Virtual plus reality versus virtual reality - A case study.
- Author
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Gnanaraj, John, Doss, Sam Arul, Stephen, S., Pratheeba, M., and Daniel, Dolly
- Subjects
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VIRTUAL reality , *FLOW cytometry , *CYTOTOXINS , *IMMUNOGLOBULINS - Abstract
Pretransplant immunological assessment of a transplant donor has evolved significantly over the last few decades with the advent of testing platforms with enhanced sensitivity and varying formats. The single antigen bead assay (SAB) assay, a virtual crossmatch (vXM) is used extensively and considered the gold standard for defining donorspecific antibodies (DSA) in many parts of the World. A country like India, is however challenged by the lack of adequate representation of locally frequent HLA alleles and hence in our institution, we continue to perform a physical crossmatch (pXM) on the Complement Dependent Cytotoxicity and flow cytometry platforms alongside the SAB. We report here a case report where the discrepancy between platforms of testing have raised certain pertinent questions in our interpretation of the vXM. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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