Search

Aim: The aim of this study is to demonstrate the technical feasibility of volumetric assessment of residual tumor volume and to evaluate the effect of a precisely defined residual tumor volume on overall survival (OS) in patients with glioblastoma (GBM). Materials and methods: Adult patients who underwent surgical resection for GBM in the University Hospital Olomouc from 2012 to 2016 were selected retrospectively. Patients attended regular clinical and MRI follow-up every three months. Early postoperative MRI scans were used in the study. In each patient, tumor segmentation was performed followed by creating a 3D model of tumor volume, which allowed the calculation of its volume both before and after surgery. Results: Results of 50 patients were available for a retrospective analysis. Our study showed a significant prolongation of OS only in the group with no contrast-enhancing residue (median OS = 16.1 vs. 6.3 months) Patients with a combination of radical resection and oncological treatment with the Stupp protocol achieved further prolongation of OS with a mean of 19.6 months and a median of 14 months. Conclusion: Our paper describes the process of calculating the volume of the postoperative residual component of GBM using easily available software. According to the study findings, significantly better therapy results were achieved in patients with complete removal of the contrast-enhancing GBM component, supplemented by the most possible radical resection of the contrast non-enhancing components of the tumor. [ABSTRACT FROM AUTHOR]

This article, titled "OC08.03: Placenta accreta spectrum: prediction of pathological grade by ultrasound examination," aims to investigate the ultrasound diagnostic signs of placenta accreta spectrum (PAS) and their correlation with the severity of histopathological grading. The study analyzed 30 PAS cases from 2018 to 2023 and compared ultrasound signs such as myometrial thinning, loss of the clear zone, placental bulging, placental lacunaes, and uterovesical hypervascularity. The results showed that myometrial thinning and loss of the clear zone were the most significant predictors of myometrial invasion in PAS. Patients with a severe histopathological grade were at a higher risk of experiencing greater blood loss, requiring hysterectomy, and needing devascularization procedures. [Extracted from the article]

Aim: There are a lot of modifications for the surgical treatment of chronic subdural haematoma; however, the burr hole drainage is the most common procedure. The aim of our study was to compare two particular surgical procedures: burr hole drainage with preoperative irrigation of the haematoma and simple burr hole drainage. Patients and methods: Patients who were operated on the chronic subdural haematoma at our department between 2011–2016 were enrolled in the study. Burr hole drainage with irrigation was used till September 2013; since then, patients have undergone burr hole drainage without irrigation. This change in surgical technique at out department was influenced by the studies showing similar results of both surgical techniques. Thus, the distribution of patients according to the surgical technique was not influenced by selection bias. All the data needed for the evaluation of the results of both surgical techniques, especially focusing on assessing recurrences, were found retrospectively in the medical documentation. Results: There were 230 patients in our study who were treated by one of two study procedures. Eightyone patients underwent surgery with irrigation of haematoma, out of which 19 patients (23.5%) developed recurrence and 4 patients (4.9%) had to finally undergo craniotomy and membranectomy. The surgical technique without irrigation of haematoma was performed in 149 patients, and the recurrence was observed in 42 patients (28.2%) and 9 patients (6.0%) had to undergo craniotomy and membranectomy. Statistical evaluation did not prove a significant difference in effectiveness between these two surgical techniques. Conclusion: Simple burr hole drainage is as effective as burr hole drainage with irrigation according to up to date knowledge. The technique without irrigation, as less invasive and faster, seems to be better for the treatment of chronic subdural haematoma. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE "uniform requirements" for biomedical papers. [ABSTRACT FROM AUTHOR]

The authors assessed the results of colloid cyst extirpation by an endoscopic approach. The sample consisted of eleven consecutive patients with a rigid endoscope surgery achieving radical resection and requiring one conversion to open microsurgical transcortical access only. The surgical approach was always indicated individually based on preoperative imaging and experience of the authors and with an eff ort to minimize postoperative morbidity. Increasing age and concurrent hydrocephalus seem to be more important risk factors for postoperative psychological changes than the actual surgical approach. The authors refl ect on the limits and technical potential of endoscopic treatment approach and emphasize the need for individualized approach based on preoperative MRI imaging, the content of the cysts and other aspects. [ABSTRACT FROM AUTHOR]

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manu script met the ICMJE "uniform requirements" for biomedical papers. [ABSTRACT FROM AUTHOR]