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Background: The administration of colostrum through its absorption at the oropharyngeal level stimulates the mucosa-associated lymphoid tissue, providing a local immunological protection barrier. The study aimed to investigate the association of oropharyngeal colostrum administration with the reduction of inflammatory indices. Materials and methods: This was an observational, ambispective, analytical study of newborns < 32 weeks of gestation at risk of sepsis. Oropharyngeal colostrum was administered at 0.2 mL every 4 h for 5 days. Inflammatory indices were analyzed. Statistical analysis included frequencies, percentages, mean and Standard deviation, contingency coefficient, and Kolmogorov--Smirnov test for the distribution curve of the numerical data. Results: There were 50 patients, 33 (66%) female and 17 (34%) male, with a median gestational age of 30-31 weeks (95% confidence interval [CI]). Nineteen patients had sepsis. A lower positivity rate in C-reactive protein was found, with a median of 0.5-0.6 (95% CI) at 5 days of colostrum administration versus 0.5-1.1 (95% CI) as the initial C-reactive protein. Analysis with χ² yielded a p = 0.13, and the contingency coefficient showed a p = 0.196, indicating an association. Conclusion: Oropharyngeal colostrum administration was associated with a lower C-reactive protein positivity rate and clinical improvement in premature newborns at risk of sepsis. [ABSTRACT FROM AUTHOR]

Introduction: opiates and benzodiazepines are the ones that most frequently produce withdrawal syndrome. Objective: know the risk factors associated with abstinence syndrome in patients whit sedoanalgesia. Material and methods: prospective, longitudinal, analytical; newborns received sedoanalgesia with fentanyl and midazolam for more than 24 hours. The clinicaldemographic association with abstinence syndrome was analyzed using the Finnegan scale. Test t-Student, Mann-Whitney U and Mann-Whitney, χ2 for differences in different variables, logistic regression the independent variables associated with abstinence syndrome, alpha level < 0.05, SPSS v.23.0 program. Results: 84 patients, 56% male, predominated means: weeks of gestation 35 ± 3.8, weight 2,350 ± 866 g and cesarean 65.5%. To the Finnegan scale 7.1% file abstinence syndrome which 66.7% was mild and 33.3% moderate; the association between the presence of abstinence syndrome is found: cesarean, maternal age of 30 years, male, first or second gestation, 38 weeks gestation (p = 0.01), weighing greater than 2,700 g, diagnosed with post-surgical admission and mechanical ventilation. Conclusion: there is a relationship between clinical demographic variables in newborn patients receiving sedoanalgesia and the presentation of with abstinence syndrome; however further studies are required to establish and adopt preventive measures. [ABSTRACT FROM AUTHOR]

Objective: To know the association of abdominal ultrasound findings in preterm newborns with necrotizing enterocolitis. Method: Transverse, analytical study, patients with necrotizing enterocolitis abdominal ultrasound was performed: free fluid, large wall more than 2.5 mm, small bowel wall less than 1.1 mm, gas in portal vein, intestinal pneumatosis, decreased and/or absence of peristalsis, increase and/or absence of intestinal blood infusion. Chi square and Mann-Whitney U tests were used to establish association ultrasound findings and necrotizing enterocolitis, alpha level < 0.05, SPSS v.23.0 program. Results: 37 patients. IA stage: small intestine wall less than 1.1 mm with a total of 15 (40%), 13 (35%) decreased peristalsis 11 (29%), absence of peristalsis 8 (21.62%). IB stage: free liquid, increased blood infusion 2 (5%). IIA stage: peristalsis decreased 7 (18%), small intestine wall less than 1.1 mm 4 (10%), free liquid 3 (8%), pneumatosis 2 (5%), absent blood infusion 1 (2%). IIIA stage: 1 (2%) free liquid, thinning of small intestine wall less than 1.1 mm, absence of peristalsis and blood infusion. Conclusion: There is an association of ultrasonographic findings in patients with necrotizing enterocolitis. Most frequent finding: small bowel wall less than 1.1 mm, free fluid, decreased peristalsis. It would be important to implement it as a diagnostic method in all cases for medical and surgical decision-making. [ABSTRACT FROM AUTHOR]