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Association of oropharyngeal colostrum administration with decreased inflammatory indices in premature newborns weighing less than 1500 g.
- Source :
-
Boletín Médico del Hospital Infantil de México . may/jun2024, Vol. 81 Issue 3, p170-175. 6p. - Publication Year :
- 2024
-
Abstract
- Background: The administration of colostrum through its absorption at the oropharyngeal level stimulates the mucosa-associated lymphoid tissue, providing a local immunological protection barrier. The study aimed to investigate the association of oropharyngeal colostrum administration with the reduction of inflammatory indices. Materials and methods: This was an observational, ambispective, analytical study of newborns < 32 weeks of gestation at risk of sepsis. Oropharyngeal colostrum was administered at 0.2 mL every 4 h for 5 days. Inflammatory indices were analyzed. Statistical analysis included frequencies, percentages, mean and Standard deviation, contingency coefficient, and Kolmogorov--Smirnov test for the distribution curve of the numerical data. Results: There were 50 patients, 33 (66%) female and 17 (34%) male, with a median gestational age of 30-31 weeks (95% confidence interval [CI]). Nineteen patients had sepsis. A lower positivity rate in C-reactive protein was found, with a median of 0.5-0.6 (95% CI) at 5 days of colostrum administration versus 0.5-1.1 (95% CI) as the initial C-reactive protein. Analysis with χ² yielded a p = 0.13, and the contingency coefficient showed a p = 0.196, indicating an association. Conclusion: Oropharyngeal colostrum administration was associated with a lower C-reactive protein positivity rate and clinical improvement in premature newborns at risk of sepsis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 05396115
- Volume :
- 81
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Boletín Médico del Hospital Infantil de México
- Publication Type :
- Academic Journal
- Accession number :
- 178274968
- Full Text :
- https://doi.org/10.24875/BMHIM.23000048