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In the emotional narrative of sports event tourism, visual communication is key to persuading media consumers. Our aim is to examine the interplay between context (sports tourism) and text (visual and written) to shed light on the storytelling of blogs and online articles regarding sports tourism. Results show that the narrative sequence of the images, supported by text, highlights central values of sports, such as leadership, teamwork, and respect, in which the host city integrates. The emotions reflected in the corpus images point to the construction of a well-defined national identity in tourism social media when applied to sports events. [ABSTRACT FROM AUTHOR]

The aim of this paper is to analyse the social and economic implementation of the reform of industrial vocational training during Primo de Rivera's dictatorship in Spain (1923–1930), based on the Industrial Education Statute of 1924 and the Vocational Training Statute of 1928. Framed within an international context affected by the consequences of the First World War, the project formed part of an authoritative corporate structure within the ideological paradigm of "reactionary modernism": a combination of social tradition and the modernity of industrialisation, exemplified in the vocational training of industrial workers and technicians in the work schools. In particular, the objective is to identify the effects of the implementation of this reform on a local level from a training, socio-professional, political, and economic perspective. To do this, the legislative and newspaper sources of the reform have been analysed, together with annual reports and reviews of the educational centres and the statistical yearbooks of enrolment. The results indicate that, in spite of the institutional re-launch of the reform, the ideological basis of the project clashed with the specific interests of the local reality. [ABSTRACT FROM AUTHOR]

Introduction: For sciences applied to sexual behaviour, research has traditionally reported a wide variety of nonunified pools with a lack of a gold standard classification. Therefore, this work aimed to propose a comprehensive taxonomy. Methods: A broad model was developed under expert criteria using a thematic analysis of the literature. After that, a systematic review was conducted to test and extend it within the given conditions of unification. Results: 36 variables of actions and surrounding context were found and allocated in 5 groups: partner description, combinatory variables, objects associated, paraphilic behaviours and actual behaviours. 650 reports were screened, and 143 were fully assessed. Of them, one was finally selected to add to the previous model. Discussion: A comprehensive taxonomy was brought in, along with a method to expand and retest it if necessary. It is aimed to set a commonly shared framework of repertoires to enable valid comparisons among samples or individuals. [ABSTRACT FROM AUTHOR]

The study's objective is to analyze the correspondence of the role of the ideal teacher with the characteristics of the socio-constructivist paradigm, from the perspective of the diverse participant profiles in this research: graduate students in elementary education (initial and final courses, and master's program); teachers searching for employment; experienced teachers; and teacher educators. A qualitative study with a phenomenological design, using discussion groups, was based on inductive/deductive categories. The results confirm the initial hypothesis, converging in a socio-constructivist pedagogical model and the impossibilities of its implementation in the classroom. [ABSTRACT FROM AUTHOR]

Background: Etiological diagnosis of fever in children with sickle cell disease (SCD) is often challenging. The aim of this study was to analyze the pattern of inflammatory biomarkers in SCD febrile children and controls, in order to determine predictors of severe bacterial infection (SBI).Methods: A prospective, case-control study was carried out during 3 years, including patients younger than 18 years with SCD and fever (cases) and asymptomatic steady-state SCD children (controls). Clinical characteristics and laboratory parameters, including 10 serum proinflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17a, IFN-γ and TNF-α) and comparisons among study subgroups were analyzed.Results: A total of 137 patients (79 cases and 58 controls) were included in the study; 78.5% males, median age 4.1 (1.7-7.5) years. Four cases were diagnosed with SBI, 41 viral infection (VI), 33 no proven infection (NPI) and 1 bacterial-viral coinfection (the latter excluded from the subanalyses). IL-6 was significantly higher in patients with SBI than in patients with VI or NPI (163 vs 0.7 vs 0.7 pg/ml, p < 0.001), and undetectable in all controls. The rest of the cytokines analyzed did not show any significant difference. The optimal cut-off value of IL-6 for the diagnosis of SBI was 125 pg/mL, with high PPV and NPV (PPV of 100% for a prevalence rate of 5, 10 and 15% and NPV of 98.7%, 97.3% and 95.8% for those prevalences rates, respectively).Conclusion: We found that IL-6 (with a cut-off value of 125 pg/ml) was an optimal marker for SBI in this cohort of febrile SCD children, with high PPV and NPV. Therefore, given its rapid elevation, IL-6 may be useful to early discriminate SCD children at risk of SBI, in order to guide their management. [ABSTRACT FROM AUTHOR]

Summary: Bacillus cereus is a common food‐borne pathogen that is responsible for important outbreaks of food poisoning in humans. Diseases caused by B. cereus usually exhibit two major symptoms, emetic or diarrheic, depending on the toxins produced. It is assumed that after the ingestion of contaminated vegetables or processed food, spores of enterotoxigenic B. cereus reach the intestine, where they germinate and produce the enterotoxins that are responsible for food poisoning. In our study, we observed that sporulation is required for the survival of B. cereus in leaves but is dispensable in ready‐to‐eat vegetables, such as endives. We demonstrate that vegetative cells of B. cereus that are originally impaired in sporulation but not biofilm formation are able to reach the intestine and cause severe disorders in a murine model. Furthermore, our findings emphasise that the number of food poisoning cases associated with B. cereus is underestimated and suggest the need to revise the detection protocols, which are based primarily on spores and toxins. [ABSTRACT FROM AUTHOR]

This article aims to portray industrial workers' vocational training during Primo de Rivera's dictatorship in Spain (1923–1930), based on the Industrial Training Act of 1924 and the Vocational Training Act of 1928. The programme was devised to meet the modernising expectations of a conventional society. The grounds for government interventionism were laid down in a new curriculum based on the Work School, influenced by the aims of the New School, whose main objective was to create citizens and technicians. Accordingly, this article analyses, on the one hand, the ideological context that fostered the rebirth of industry-oriented training, and the influence of social Taylorism and the New School movement on the design of a newly humanised-technological programme; and, on the other hand, the corporate political manipulation by Primo de Rivera's dictatorship of the new model of training based on work schools, influenced by the idea of reactionary modernisation. [ABSTRACT FROM AUTHOR]

Allergic rhinitis has become a global health problem in recent decades because airborne pollen is a primary trigger of this respiratory disorder. Moreover, pollinosis can exacerbate the symptoms of asthma and favour respiratory infections. Seasonal pollen trends and climatic circumstances (such as temperature, precipitation, relative humidity, wind speed and direction, and other variables) can impact daily airborne pollen concentrations, influencing local pollen emission and dispersion. Because of that, pollen monitoring and prediction are becoming more relevant to the urban population and scientific interest is put into them. Due to such tasks' high volume of data, scientists are starting to use computational tools like workflows to automate and speed up the process. Furthermore, using the expert scientific domain is critical for improving the analysis, allowing, among others, a better workflow configuration and data provenance. As semantic web technologies have been revealed as an essential means for knowledge representation, we implemented this workflow information as an ontology using formats like RDF(S) and OWL. Consequently, this paper provides a semantic-enhanced e-Science workflow based on the TITAN framework for pollen forecasting analysis using meteorological data. Furthermore, a catalogue of components is developed on the TITAN framework, which allows the creation of different workflow versions. Two case studies of pollen prediction were developed to test the implementation of the aforementioned methodologies. Both were elaborated with airborne pollen data obtained in the city of Málaga (Spain). Still, one was elaborated for Platanus pollen type (narrow annual main pollination period), while the other was done for Amaranthaceae pollen type (extensive annual main pollination period). The predictions have been conducted using machine and deep learning algorithms like SARIMA or CNN-LSTM that intend to optimise the pollen prediction procedure depending on its stational and seasonal profile. [ABSTRACT FROM AUTHOR]

Objective: to identify the level of knowledge that the students of a public university in Manizales have about Human Papillomavirus (HPV). Methodology and methods: this is a descriptive, cross-cutting method study carried out with a population of 1,935 students registered at Universidad de Caldas during the 2009-II academic period. One stratified random sample of 536 students from both gender all belonging to academic undergraduate programs who were in the first semester with 70 to 84 credit hours already accredited, was taken. A survey was applied to determine the social-demographic characteristics and the knowledge about HPV. Results: 25% of the surveyed students who participated in the survey have a high level of knowledge about HPV, 32% have a mid level of knowledge, 23% have a low level of knowledge, and 20% don`t have any knowledge about HPV. After the analysis it can be observed that the social-demographic characteristics taken into account are related with the level of knowledge the students have. It is important to highlight the deep lack of knowledge in areas such as the types of lesions the virus causes (70.5%), the patients in whom these lesions are commonly present (69%), which the risk factors to get infected are (72.6%), the diagnosis (63.2%), and how to prevent it (54%). Conclusions: the lack of knowledge about HPV is high among the surveyed population which can be considered as one of the main risk factors to get infected with HPV. As a consequence, it is necessary to start implementing specific sex health education programs at the University. [ABSTRACT FROM AUTHOR]

This article offers an analysis of 20 semi-directed, open interviews realized with street children in Mexico City, which includes diverse topics (Family, Violence, Sexuality, Obtaining Resources and Addictions) and considers two life stages (before abandoning the home and their life on the street). These groups live in an environment with conditions of vulnerability, where the satisfaction of basic necessities is the primary focus of their decision making, causing lack of future expectations. One of their behavior patterns is drug abuse, solvents being the most typical drug of choice. Their sexuality, acted out in conditions of vulnerability, gives rise to frequent unwanted pregnancies and genital infections. In this context, the reproductive health of these marginal groups will have to be considered. [ABSTRACT FROM AUTHOR]

Background. Screening strategies for the detection of aneuploidies should be performed by every Prenatal Diagnosis Service. Several screening approaches have been developed, reaching detection rates of at least 85% for a 5% false-positive rate. Our experience in a population with a high percent of women aged 35 or older using combined screening is presented. Methods. From July 1999 to October 2004, we conducted a prospective study of screening for fetal aneuploidies among pregnant women between 10 and 14 weeks. Risks for aneuploidy were calculated by combined screening, using maternal age, maternal serum free-βhCG, pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency. The result was considered positive if the combined risk exceeded the cut off risk of 1/270. Results. Screening was completed in 4538 singleton pregnancies. The mean maternal age was 31.08 years, and in 25.9% the age was 35 years or greater. The detection rate was 76.9% (30/39) for all aneuploidies with a false-positive rate of 3,6%. For trisomy 21, the detection rate was 7.7% (14/19) with a false-positive rate of 3.6%. At a 5% false-positive rate, the sensitivity of combined screening and nuchal translucency were 78.9% and 63.2% respectively. Conclusion. First trimester combined screening is efficient, and its application can be assumed in a tertiary-hospital. [ABSTRACT FROM AUTHOR]

Background: Arsenic (As) is a well-recognized poison. Exposure may be of an acute nature, leading to high concentrations and acute arsenic poisoning. Chronic exposure may lead to benign skin changes, skin cancer, and internal malignancy. Objective: Our purpose was to study the nature, incidence, and sequelae of skin disorders in a group of Argentinean patients suffering from chronic arsenicism due to the intake of contaminated well water. Methods: All patients who presented with chronic arsenicism at the Dermatology Department of Hospital Posadas (Buenos Aires, Argentina) during a 10-year period (1988–1998) were included in this study. The patient group compromised 9 women and 14 men, the age range was 37–72 years. Diagnosis was based on the clinical triad (keratoderma, leucoderma and epiteliomatosis). We performed clinical, laboratory, and histopathologic studies to confirm diagnosis. We screened for possible internal diseases. Results: All patients included in this study had cutaneous lesions associated with long-term arsenic exposure. The mean age of the patients was 58.2 years. The estimated mean time of the beginning of the lesions was of 3.7 years. All patients were Argentinean from endemic areas of our country where the arsenic levels are higher than those accepted by the World Health Organization. Conclusion: This study allows us to conclude that the relationship between arsenic and cancer is frequent and it describes the principal characteristics of this entity in our group of patients. Antécédents: L'arsenic (As) est un poison bien connu. L'exposition peut etre de nature aigue, conduisant a de hautes concentrations et a un empoisonnement aigue a l'arsenic. Une exposition chronique peut conduire a des changements cutanes benins, cancer de la peau et malignite interne. Objectif: Notre but est d'eturdier la nature, 1'incidence, et les sequelles de maladies cutanees chez un groupe de patients argentins souffrant d'arsenicisme chronique du a l'ingestion d'eau provenant d'un puits contamine. Méthodes: Tous les patients qui se presentaient avec un arsenicisme chronique dans le departement de dermatologie de l'Hopital Posadas (Buenos Aires, Argentine) pendant une periode de dix ans (1988–1998) furent inclus dans cette etude. Le groupe de patients etait compose de neuf femmes et quatorze hommes, l'age variant entre 37 et 72 ans. Le diagnostic etait fonde sur la triade clinique: keratodermie, leucodermie, et epitheliomatose. Nous avons effectue des etudes cliniques, histopathologiques, et de laboratoire pour confirmer le diagnostic. Nous avons examine et elimine d'autres maladies internes possibles. Resultats: Tous les patients inclus dans cette etude avaient des lesions cutanees associees a une exposition de longue duree a 1'arsenic. L'age moyen des patients etait de 58.2 ans. La moyenne estimee de la duree depuis le commencement des lesions etait de 3.7 ans. Tous les patients etaient argentins provenant de zones endemiques du pays ou les niveaux d'arsenic sont plus eleves que ceux acceptes par l'Organisation Mondiale de la Sante. Conclusion: Cette etude nous permet de conclure que le rapport entre arsenic et cancer est frequent et decrit les characteristiques principals de cette entite dans notre groupe de patients. [ABSTRACT FROM AUTHOR]

Background: The prospective phase IV AVAMET study was undertaken to correlate response evaluation criteria in solid tumors (RECIST)-defined response rates with computed tomography-based morphological criteria (CTMC) and pathological response after liver resection of colorectal cancer metastases. Methods: Eligible patients were aged ≥18 years, with Eastern Cooperative Oncology Group (ECOG) performance status 0/1 and histologically-confirmed colon or rectal adenocarcinoma with measurable liver metastases. Preoperative treatment was bevacizumab (7.5 mg on day 1) + XELOX (oxaliplatin 130 mg/m2, capecitabine 1000 mg/m2 bid on days 1–14 q3w). After three cycles, response was evaluated by a multidisciplinary team. Patients who were progression-free and metastasectomy candidates received one cycle of XELOX before undergoing surgery 3–5 weeks later, followed by four cycles of bevacizumab + XELOX. Results: A total of 83 patients entered the study; 68 were eligible for RECIST, 67 for CTMC, and 51 for pathological response evaluation. Of these patients, 49% had a complete or partial RECIST response, 91% had an optimal or incomplete CTMC response, and 81% had a complete or major pathological response. CTMC response predicted 37 of 41 pathological responses versus 23 of 41 responses predicted using RECIST (p = 0.008). Kappa coefficients indicated a lack of correlation between the results of RECIST and morphological responses and between morphological and pathological response rates. Conclusion: CTMC may represent a better marker of pathological response to bevacizumab + XELOX than RECIST in patients with potentially-resectable CRC liver metastases. [ABSTRACT FROM AUTHOR]

Heritage and space establish reciprocal relations that have been studied for decades. On the one hand, heritage has been described as an inherently spatial phenomenon. On the other hand, places are defined according to the attributes that make up their identity, among which heritage is a fundamental instrument. On the basis of the idea that education plays an important role in the socialization process, transmitted by the inherited culture, to integrate each subject within the specific community, and the notion of scale as the closest to heritage, we defined as general objectives to determine the relationships between geographic scales, heritage perspective and the didactic potential granted to heritage, within the framework of the construction of collective identities, and to contrast the perspectives of students and teachers regarding the geographical scale, heritage and their didactic potential, deducing implications for educational practices. In order to answer to these objectives, we carried out a non-experimental quantitative research, with a relational-predictive objective. Specifically, we used a survey method, being the context the whole of the local scale (Fuente Álamo, Murcia, Spain) and acting as participants all students and teachers of Secondary Education (n = 459) linked to social sciences. They answered the Test on Didactic Potentiality of Heritage according to Scale (TDPHS), and its information was analysed through different procedures (Spearman's correlations, descriptive statistics, Mann-Whitney U...), using the statistical programs SPSS. The results show, on the one hand, that the scalar perspective scores are generally low, heritage perspective is consistent with the consideration of the scales, and the perceived didactic potential in relation to heritage is related to the importance given to each of the scales; and, on the other hand, the contrast in the perspectives of students and teachers regarding the geographical scale, heritage and their didactic potential is minimal. [ABSTRACT FROM AUTHOR]

This paper describes a system for recommending hiking routes to help manage hiking activities in a protected area. The system proposes various routes, based on five criteria that maximize some aspects of hikers’ requirements (by analyzing the viability and difficulty of the trails) and also those of protected areas managers (by proposals to relieve congestion in areas already used for hiking and to promote awareness of new ones, as a contribution to environmental education). The recommendation system uses network analysis, multi-criteria decision analysis and geographic information system by free software tools: PgRouting, PostgreSQL and PostGIS. This system has been tested in Sierra de las Nieves Nature Reserve (Andalusia, Spain). Of the 182 routes obtained by the system, 62 (34%) are considered viable for hikers in Sierra de las Nieves, taking into account the type of user most likely to visit this protected area. Most routes have a high difficulty level, which is coherent with the mountainous character of the protected area. [ABSTRACT FROM AUTHOR]

Background: It is known that SARS-CoV-2 antibodies from pregnant women with SARS-CoV-2 infection during pregnancy cross the placenta but the duration and the protective effect of these antibodies in infants is scarce. Methods: This prospective study included mothers with SARS-COV-2 infection during pregnancy and their infants from April 2020 to March 2021. IgG antibodies to SARS-CoV-2 spike protein were performed on women and infants at birth and at two and six months during follow-up. Anthropometrical measures and physical and neurological examinations and a clinical history of symptoms and COVID-19 diagnosis were collected. Simple linear regression was performed to compare categorical and continuous variables. To compare the mother's and infant's antibody titers evolution, a mixed linear regression model was used. A predictive model of newborn antibody titers at birth has been established by means of simple stepwise linear regression. Results: 51 mother-infant couples were included. 45 (90%) of the mothers and 44 (86.3%) of the newborns had a positive serology al birth. These antibodies were progressively decreasing and were positive in 34 (66.7%) and 7 (13.7%) of infants at 2 and 6 months, respectively. IgG titers of newborns at birth were related to mothers' titers, with a positive moderate correlation (Pearson's correlation coefficient: 0.82, p < 0,001). Fetal/maternal antibodies placental transference rate was 1.3 (IQR: 0.7–2.2). The maternal IgG titers at delivery and the type of maternal infection (acute, recent, or past infection) was significantly related with infants' antibody titers at birth. No other epidemiological or clinical factors were related to antibodies titers. Neurodevelopment, psychomotor development, and growth were normal in 94.2% of infants in the third follow-up visit. No infants had a COVID-19 diagnosis during the follow-up period. Conclusions: Transplacental transfer of maternal antibodies is high in newborns from mothers with recent or past infection at delivery, but these antibodies decrease after the first months of life. Infant's IgG titers were related to maternal IgG titers at delivery. Further studies are needed to learn about the protective role of maternal antibodies in infants. [ABSTRACT FROM AUTHOR]

Background: Important prevention efforts have led to a reduction in mother-to-child transmission of HIV (MTCT) globally. However, new cases of paediatric HIV infections still occur. Early diagnosis of new HIV infections is essential to start an appropriate antiretroviral treatment to avoid childhood morbidity and mortality related to infection. The aim of this study was to describe the new cases of MTCT in Latin-American referral hospitals.Methods: A retrospective, multicentre and descriptive study of the new cases of MTCT diagnosed during 2018 in 13 referral hospitals from 8 Latin-American countries (Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, and Panama) belonging to PLANTAIDS (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children), was conducted. PLANTAIDS is included in CYTED (Ibero-American Programme of Science and Technology for Development).Results: Eighty-one children (40.7% males) were included, median age at diagnosis of 2.33 years (IQR:0.7-4.7). Less than 3% of women knew their HIV diagnosis before pregnancy. More than 80% of them were diagnosed after delivery, 8.7% during pregnancy, and 2.9% at delivery. Only one patient underwent antiretroviral therapy (ART) prior to pregnancy. At diagnosis, 50.0% of the children presented with an advanced stage of disease (stage C following the current CDC classification for HIV infection), and 34.4% had less than 15% CD4+ cells/mm3. The time elapsed between delivery and the maternal diagnosis was correlated with the age of children at diagnosis, ρ = 0.760, p < 0.001. Younger age at diagnosis (p = 0.03), a smaller number of previous hospitalizations (p < 0.01), and better immunovirological status (p < 0.01) were found in children whose mothers knew their HIV status at delivery, compared to mothers who were not aware of it.Conclusions: Although MTCT in Latin America has declined in recent years, our series shows there are still cases that indicate some failures in prevention, being a critical point to improve an earlier diagnosis of pregnant women. Half of the children were diagnosed in an advanced stage of disease and the delay in maternal diagnosis entailed a worse clinical and immunological child' prognosis. [ABSTRACT FROM AUTHOR]

El síndrome PFAPA es una enfermedad autoinflamatoria de diagnóstico clínico. Se han propuesto diversos tratamientos; entre ellos, la tonsilectomía podría ser un tratamiento efectivo. Estudio multicéntrico retrospectivo. Se incluyeron pacientes diagnosticados de síndrome PFAPA, según los criterios de Thomas, en 3 hospitales madrileños, entre 2009-2013. Se incluyeron 32 casos. Las medianas de edad de inicio del cuadro y al diagnóstico fueron 32 meses (RIQ 24-44) y 47,5 meses (RIQ 37-60), respectivamente. Se hallaron incrementos en las cifras de leucocitos (13.580/μl [RIQ 8.200-16.600] vs. 8.300/μl [RIQ 7.130-9.650], p = 0,005), neutrófilos (9.340/μl [RIQ 5.900-11.620] vs. 3.660/μl [RIQ 2.950-4.580], p = 0,002) y proteína C reactiva (11,0 mg/dl [RIQ 6,6-12,7] vs. 0,2 mg/dl [RIQ 0,1-0,6], p = 0,003) durante los episodios febriles, respecto a los periodos libres de síntomas. El 80,8% refería remisión de los síntomas en 24 h tras corticoterapia oral. Fueron tonsilectomizados 14 pacientes. En 11 cesaron los episodios febriles, mientras que en 3 se redujo su frecuencia; hubo 2 sangrados posquirúrgicos como complicación. El cuadro se había resuelto en el 56,3% de los pacientes, a una mediana de edad de 60 meses (RIQ 47-95), con una duración similar entre los pacientes que fueron tonsilectomizados y los que no. Se presenta una cohorte amplia de niños con síndrome de PFAPA en la que se confirma que, en nuestro medio, los niños con este síndrome presentan unas características clínicas y analíticas similares a las descritas en la literatura, con buena respuesta a corticoterapia y elevada resolución de la clínica tras la amigdalectomía. PFAPA syndrome is an autoinflammatory disease whose diagnosis is mainly clinical. Several treatments have been proposed; among them, tonsillectomy could be an effective one. Retrospective multicenter study. Patients included were diagnosed with PFAPA syndrome, according to the Thomas criteria, in 3 hospitals in Madrid between 2009-2013. Thirty-two cases were included. Median age at onset and at diagnosis were 32 months (IQR 24-44) and 47.5 months (IQR 37-60), respectively. There were increases in leukocytes (13,580/μL [IQR 8,200-16,600] vs. 8,300/μL [IQR 7,130-9,650], P =.005), neutrophils (9,340/μL [IQR 5,900-11,620] vs. 3,660/μL [IQR 2,950-4,580], P =.002) and C-reactive protein (11.0 mg/dL [IQR 6.6-12.7] vs. 0.2 mg/dL [IQR 0.1-0.6], P =.003) during febrile episodes. In all, 80.8% of patients reported remission of symptoms within 24 h after oral corticosteroid therapy. Fourteen patients were tonsillectomized. In 11, the febrile episodes stopped while, in 3, the frequency was reduced; there were 2 cases of postoperative bleeding. The disease was resolved in 56.3% of the patients, at a median age of 60 months (IQR 47-95), with similar duration in patients who were tonsillectomized and those who were not. We present a large cohort of children with PFAPA syndrome, with clinical and analytical features similar to those described in the literature, and a good response to corticosteroids and a high resolution rate of symptoms after tonsillectomy. [ABSTRACT FROM AUTHOR]

This is a 54-year-old patient who started with an injury to the vulva at the level of the scar of the raffia for about four years, which evolves and abscess, what has been treated several times, without improvement, so it continued with bleeding and pain in the region of the vulva. He decided to go to the Gynecological Consultation of the Mariana Grajales Hospital of Santa Clara, and she was diagnosed with a lesion in the vulvar fork of 3 cm, raised, with indurated and ulcerated edges. The clinical characteristics of the lesion are resolved in the Gynecology Room and a vulvectomy is performed with bilateral inguinal lymphadenectomy. The histological diagnosis consisted of a syringocistadenocarcinoma of the ulcerated infiltrating papillary vulva. Syringocistadenocarcinoma papilliferum is a malignant tumor derived from the sweat glands extremely infrequent. It is located, predominantly, in the head and neck and may develop a papilliferous syringocistadenoma or a sebaceous neva of Jadassohn; Its location in the vulva is uncommon. [ABSTRACT FROM AUTHOR]

Erythema multiforme is exceptional in newborns, and none of the few available reports has revealed a clear etiologic agent, not even herpes simplex virus. Immunocompetent patients rarely present with cutaneous cytomegalovirus involvement, and few cases of cytomegalovirus-associated erythema multiforme have been described, none of them in newborns. We report the first case of erythema multiforme in a newborn associated with cytomegalovirus infection. [ABSTRACT FROM AUTHOR]