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First trimester combined screening for chromosomal defects: Our results in a population with a high percent of women aged 35 or older.
- Source :
-
Ultrasound Review of Obstetrics & Gynecology . Sep2005, Vol. 5 Issue 3, p178-185. 8p. - Publication Year :
- 2005
-
Abstract
- Background. Screening strategies for the detection of aneuploidies should be performed by every Prenatal Diagnosis Service. Several screening approaches have been developed, reaching detection rates of at least 85% for a 5% false-positive rate. Our experience in a population with a high percent of women aged 35 or older using combined screening is presented. Methods. From July 1999 to October 2004, we conducted a prospective study of screening for fetal aneuploidies among pregnant women between 10 and 14 weeks. Risks for aneuploidy were calculated by combined screening, using maternal age, maternal serum free-βhCG, pregnancy-associated plasma protein-A (PAPP-A) and fetal nuchal translucency. The result was considered positive if the combined risk exceeded the cut off risk of 1/270. Results. Screening was completed in 4538 singleton pregnancies. The mean maternal age was 31.08 years, and in 25.9% the age was 35 years or greater. The detection rate was 76.9% (30/39) for all aneuploidies with a false-positive rate of 3,6%. For trisomy 21, the detection rate was 7.7% (14/19) with a false-positive rate of 3.6%. At a 5% false-positive rate, the sensitivity of combined screening and nuchal translucency were 78.9% and 63.2% respectively. Conclusion. First trimester combined screening is efficient, and its application can be assumed in a tertiary-hospital. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14722240
- Volume :
- 5
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Ultrasound Review of Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 18926465
- Full Text :
- https://doi.org/10.1080/14722240500284468