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Choroidal plexus tumors are rare and comprise 0.4 - 0.6% of brain tumors. We present the case of a 63-year-old male patient with a one-month history of behavioral alterations, decreased memory, holocranial headache and temporospatial disorientation. The diagnostic approach culminated with the diagnosis of choroidal plexus carcinoma. [ABSTRACT FROM AUTHOR]

We extend Makkai's proof of strong amalgamation (push-outs of monos along arbitrary maps are monos) from the category of Heyting algebras to a class which includes the categories of symmetric bounded distributive lattices, symmetric Heyting algebras, Heyting modal S4-algebras, Heyting modal bi-S4-algebras, and L̵ukasiewicz n-valued algebras. We also extend and improve Pitt's proof that strong amalgamation implies Beck–Chevalley for filters of Heyting algebras to exact categories with certain push-outs. As a consequence, a form of the Interpolation Lemma for some non-classical calculi is proved. [Copyright &y& Elsevier]

The enantiomers of diquats (DQs), a new class of functional organic molecules, were recently separated by capillary electrophoresis (CE) with high resolution up to 11.4 within 5–7 min using randomly sulfated α‐, β‐, and γ‐cyclodextrins (CDs) as chiral selectors. These results indicated strong interactions between dicationic diquats and multiply negatively charged sulfated CDs (S‐CDs). However, the binding strength of these interactions was not quantified. For that reason, in this study, affinity CE was applied for the determination of the binding constants and ionic mobilities of the complexes of DQ P‐ and M‐enantiomers with CD chiral selectors in an aqueous medium. The non‐covalent interactions of 10 pairs of DQ enantiomers with the above CDs were investigated in a background electrolyte (BGE) composed of 22 mM NaOH, 35 mM H3PO4, pH 2.5, and 0.0–1.0 mM concentrations of CDs. The average apparent binding constant and the average actual ionic mobility of the DQ‐CD complexes were determined by nonlinear regression analysis of the dependence of the effective mobility of DQ enantiomers on the concentration of CDs in the BGE. The complexes were found to be relatively strong with the averaged apparent binding constants in the range 13 600–547 400 L/mol. [ABSTRACT FROM AUTHOR]

Diquats, derivatives of the widely used herbicide diquat, represent a new class of functional organic molecules. A combination of their special electrochemical properties and axial chirality could potentially result in their important applications in supramolecular chemistry, chiral catalysis, and chiral analysis. However, prior to their practical applications, the diquats have to be prepared in enantiomerically pure forms and the enantiomeric purity of their P‐ and M‐isomers has to be checked. Hence, a chiral capillary electrophoresis (CE) method has been developed and applied for separation of P‐ and M‐enantiomers of 11 new diquats. Fast and better than baseline CE separations of enantiomers of all 11 diquats within a short time 5–7 min were achieved using acidic buffer, 22 mM NaOH, 35 mM H3PO4, pH 2.5, as a background electrolyte, and 6 mM randomly sulfated α‐, β‐, and γ‐cyclodextrins as chiral selectors. The most successful selector was sulfated γ‐cyclodextrin, which baseline separated the enantiomers of all 11 diquats, followed by sulfated β‐cyclodextrin and sulfated α‐cyclodextrin, which baseline separated enantiomers of 10 and nine diquats, respectively. Using this method, a high enantiopurity degree of the isolated P‐ and M‐enantiomers of three diquats with a defined absolute configuration was confirmed and their migration order was identified. [ABSTRACT FROM AUTHOR]

Abstract: Thermoelectric power (TEP) of an Inconel 718 superalloy with different microstructure states has been followed during stressing tests. In all cases plastic deformation has been attained. TEP measurement variations of ∼35nV/°C have been found in microstructural states with desirable phases. Treatments that produce non-desirable phase have shown lower variations. Results indicate that TEP of the Inconel 718 is clearly affected by the elastic and plastic strain induced during tests. A model of the material ΔTEP behaviour induced by the strain is proposed. Thus these encouraged results suggest the TEP technique as a powerful tool to detect non-desirable states and levels of strain into the Inconel 718. [Copyright &y& Elsevier]

Introduction: Major orthopedic surgery such as total hip arthroplasty (THA) is associated with an increased risk of postoperative complications. Candidates for THA are often older adults, with comorbidities that increase the risk of major bleeding, the IMPROVE scale has independent actors on the risk of bleeding according to the characteristics of the patients at hospital admission. It foresees the possibility of hemorrhage and the need for blood transfusion, being support in decision-making in the planning of a safe THA with the provision of the necessary resources. Objective: To evaluate the sensitivity, validity and reliability of the modified IMPROVE scale in patients undergoing primary total hip arthroplasty. Material and methods: Study of processes with a sample of 131 patients undergoing primary THA, in the period from January 01, 2018 to July 01, 2018. Results: The scale presents good reliability, as for the performance of the scale, a good sensitivity was obtained, classifying 96.9% of the patients correctly; which is suitable for the type of scale. Conclusions: The modified IMPROVE scale is a discretely adequate and useful tool for the prognosis of bleeding risk in patients who undergo THA, compared with other assessment scales developed in other geographical areas. It is recommended to continue with the study of risk factors for major bleeding in this specific population. [ABSTRACT FROM AUTHOR]

Difficulty in imaging the vertebrate intestine in vivo has hindered our ability to model nutrient and protein trafficking from both the lumenal and basolateral aspects of enterocytes. Our goal was to use live confocal imaging to increase understanding of intestinal trafficking of dietary cholesterol and apolipoprotein A-I (APOA-I), the main structural component of high-density lipoproteins. We developed a novel assay to visualize live dietary cholesterol trafficking in the zebrafish intestine by feeding TopFluor-cholesterol (TF-cholesterol), a fluorescent cholesterol analog, in a lipid-rich, chicken egg yolk feed. Quantitative microscopy of transgenic zebrafish expressing fluorescently tagged protein markers of early, recycling, and late endosomes/lysosomes provided the first evidence, to our knowledge, of cholesterol transport in the intestinal endosomal-lysosomal trafficking system. To study APOA-I dynamics, transgenic zebrafish expressing an APOA-I fluorescent fusion protein (APOA-I-mCherry) from tissue-specific promoters were created. These zebrafish demonstrated that APOA-I-mCherry derived from the intestine accumulated in the liver and vice versa. Additionally, intracellular APOA-I-mCherry localized to endosomes and lysosomes in the intestine and liver. Moreover, live imaging demonstrated that APOA-I-mCherry colocalized with dietary TF-cholesterol in enterocytes, and this colocalization increased with feeding time. This study provides a new set of tools for the study of cellular lipid biology and elucidates a key role for endosomal-lysosomal trafficking of intestinal cholesterol and APOA-I. [ABSTRACT FROM AUTHOR]

BACKGROUND: Metabolic syndrome is a cluster of factors that increases the risk for developing type 2 diabetes mellitus and cardiovascular disease (CVD): central obesity, elevated fasting plasma glucose, arterial hypertension, raised triglycerides and reduced high-density lipoprotein cholesterol (HDL-C). Metabolic syndrome and obesity are entities in which chronic subclinical inflammation develops, an independent risk factor for atherosclerosis and CVD. Neutrophil to lymphocyte ratio (NLR) has emerged as a prognostic marker associated to a proinflammatory state, which reflects the balance between innate and adaptive immune responses. OBJECTIVE: To define the relation between an elevated NLR and the presence of metabolic syndrome in active employees that attend to PEMEX North Central Hospital. Secondary objectives were to establish the relation between NLR and each component of metabolic syndrome individually. MATERIAL AND METHOD: A retrospective, cross-sectional and observational stud was done including employees 18-65 years old and classified them into 2 groups according to metabolic syndrome criteria, NLR was calculated for every patient. RESULTS: Of 334 evaluated patients, 155 (46%) didn't meet the metabolic syndrome criteria, and 179 (54%) did. Fifty-seven patients in the highest quartile of NLR (>2.12) corresponded to the metabolic syndrome group (p=0.000). Point biserial correlation coefficient between NLR and metabolic syndrome was 0.235 (p=0.000). Sixty-nine of the 235 patients with central obesity were at the highest quartile of NLR (p=0.001). CONCLUSION: These findings suggest that there is a statistically significant relation between elevated NLR (>2.12) and presence of metabolic syndrome and central obesity. [ABSTRACT FROM AUTHOR]

BACKGROUND: Due to increasing prevalence of type 2 diabetes mellitus (T2DM) and the overall aging of the population, the number of elderly patients with T2DM is continuously growing. Given the risks associated with intensive glycemic control of those patients, the possibility of overtreatment must be considered. OBJECTIVE: To determine the prevalence of intensive glycemic control and overtreatment in individuals >60 years with T2DM. MATERIAL AND METHOD: An observational, cross-sectional, retrospective and analytical study was done from 2013 to 2015. Individuals >60 years o ld withT2DM, glycated hemoglobin (HbA1c) <7%, and use of hypoglycemic agents were included. Patients were divided into two groups: intensive glycemic control (HbA1c 6.6-7%) and overtreatment (HbA1c <6.5%). Cardiovascular and non-cardiovascular complications associated with treatment were compared by Z-test. RESULTS: There were included 13,229 patients older than 60 years with T2DM; 4,381 in 2013, 16% (n=701) was classified as intensive glycemic control and 6% (n=256) as overtreatment; 4,383 in 2014, 16% (n=697) as intensive glycemic control and 6% (n=252) as overtreatment; 4,465 in 2015, 16% (n=708) as intensive glycemic control and 6% (n=260) as overtreatment. By this period, adverse outcomes were reported in 5%, 3% and 1% during 2013, 2014 and 2015, respectively; referring to intensive glycemic control group. Likewise, adverse outcomes were reported in 4% and 6% during 2013 and 2015, respectively; referring to overtreatment group. A value of Z-test -2.90 (p<0.05) was obtained, which was increased in overtreatment group. CONCLUSIONS: All data collected during the study highlights a significant increase of cardiovascular and non-cardiovascular adverse outcomes in patients with strict glycemic management, being hypoglycemia the most frequent; 16% are in intensive glycemic control and 6% in overtreatment. [ABSTRACT FROM AUTHOR]

BACKGROUND: Hemodialysis (HD) and peritoneal dialysis (PD) correct some patient symptoms causing changes in the lifestyle. Studies show improved quality of life in PD compared with HD. The scale Kidney Disease Quality of Life (KDQOL SF 36) adequately assesses the quality of life. OBJECTIVE: To show higher scores on the scale of quality of life of patients with peritoneal dialysis (PD) for more than 4 years compared to patients on hemodialysis (HD). MATERIAL AND METHOD: An observational, transversal, descriptive, multicenter study, performed from April 1st to May 31st, 2016. The KDQOL SF 36 scale was used in PD or HD patients in North Central Hospital and Poza Rica Regional Hospital, Mexico. The results were compared with t-Student and χ². RESULTS: Mental effects in the group of PD 39.5% vs47% in HD, p 0.05; physical effects on DP 34% vs 3 5% in HD, p 0.758; burden of kidney disease on PD 27% vs 4 6% in HD, p 0.03; effects of kidney disease in PD 61% vs55% in HD, p 0.391; symptoms in PD 71% vs 71% in HD, p 0.893. CONCLUSIONS: Peritoneal dialysis has better score than hemodialysis on effects of kidney disease; PD with lower score that HD in burden of kidney disease, mental effects area; in physical effects, symptoms area with no statistical difference. No significant difference in longterm dialysis (>4 years) between both groups. Therefore, the physician and patient should find dialysis modality that best fits their needs and lifestyle adjustment. [ABSTRACT FROM AUTHOR]

This paper reports the case of a 71-years-old male with dermatological manifestation as an initial sign of myelodysplastic syndrome, characterized by sudden onset of fever, leukocytosis and skin lesions (papules, erythematous plaques or nodules, well-defined, sensitive to touch, with or without vesicles; histologically with neutrophilic infiltrate in the papillary dermis without leukocytoclastic vasculitis). Twenty percent of cases are associated with malignancies, as it was in this patient, of these 80% were hematologic (polycythemia vera, myelodysplastic syndrome and acute myeloid leukemia). [ABSTRACT FROM AUTHOR]

BACKGROUND: Increasing antimicrobial resistance is now a major threat to public health. Enterobacteriaceae with extended-spectrum beta-lactamase (ESBL) are recognized as a major cause of nosocomial and community acquired infections. Its development is related to the misuse of antibiotics, mainly third generation cephalosporins. OBJECTIVE: To analyze the development of ESBL enterobacteria, during the years 2012, 2013 and 2014 in blood and urine isolates to determine if there is a statistically significant increase. MATERIAL AND METHOD: An observational, cross-sectional, retrospective and analytical study was done. Categorical variables were compared using χ² test with Yates continuity correction. RESULTS: 1,019 isolates were reported: Blood isolates: In 2012: 49% ESBL and 51% not ESBL. In 2013: 71% ESBL and 29% not ESBL. In 2014: 59% ESBL and 41% not ESBL. Urine isolates: In 2012: 28% ESBL and 72% not ESBL. In 2013: 27% ESBL and 73% not ESBL. In 2014: 33% ESBL and 67% not ESBL. Blood isolates were obtained for p=0.1273 and urine isolates p= 0.2366. CONCLUSIONS: There was no statistically significant increase. It was shown a high development of ESBL. The prevalence of ESBL is important because it confers resistance to multiple antibiotic including ceftriaxone, one of the antibiotics mostly used, also helps to generate strategies for their control. [ABSTRACT FROM AUTHOR]

The purpose of this study is to better understand Nutritionist-Dietician opinions concerning WIC Program strategies to promote breastfeeding in Puerto Rico. Four groups of nutritionists-dietitians were recruited to take part in focus group discussions. Each focus group lasted for approximately 1 h and the researchers completed a debriefing sheet after each meeting. The group discussions were taped and transcribed. The participants identified hospital barriers, lack of family support and problems related to the mother as the three principal reasons that Puerto Rican mothers do not breastfeed their babies or stop breastfeeding early. An individual meeting was the most frequently mentioned WIC strategy that was meant to convince mothers to breastfeed their infants. Nevertheless, the focus group participants recognized that the effort and time available for such meetings is limited. From these groups, one theme that emerged is that the WIC Program in Puerto Rico should collaborate with hospitals to arrange for WIC-sponsored nutritionist-dietitians to visit the WIC participants during their maternity hospital stay, and in their homes. [ABSTRACT FROM AUTHOR]

DUBs (deubiquitinating enzymes) are a family of proteases responsible for the specific removal of ubiquitin attached to target proteins and thus control the free cellular pools of this molecule. DUB activity is usually assayed using full-length ubiquitin, and these enzymes generally show low activity towards small substrates that constitute the P4–P1 LRGG (Lys-Arg-Gly-Gly) C-terminal motif of ubiquitin. To gain insight into the C-terminal recognition region of ubiquitin by DUBs, we synthesized positional scanning libraries of fluorigenic tetrapeptides and tested them on three examples of human DUBs [OTU-1 (ovarian tumour 1), Iso-T (isopeptidase T) and UCH-L3 (ubiquitin C-terminal hydrolase L3)] and one viral ubiquitin-specific protease, namely PLpro (papain-like protease) from SARS (severe acute respiratory syndrome) virus. In most cases the results show flexibility in the P4 position, very high specificity for arginine in the P3 position and glycine in the P2 position, in accord with the sequence of the natural substrate, ubiquitin. Surprisingly, screening of the P2 position revealed that UCH-L3, in contrast with all the other tested DUBs, demonstrates substantial tolerance of alanine and valine at P2, and a parallel analysis using the appropriate mutation of the full-length ubiquitin confirms this. We have also used an optimal tetrapeptide substrate, acetyl-Lys-Arg-Gly-Gly-7-amino-4-methylcoumarin, to investigate the activation mechanism of DUBs by ubiquitin and elevated salt concentration. Together, our results reveal the importance of the dual features of (1) substrate specificity and (2) the mechanism of ubiquitin binding in determining deubiquitination by this group of proteases. [ABSTRACT FROM AUTHOR]

One method for the synthesis of cobalt (III) hydroxide of industrial liquors from the cobalt and nickel sulfide dissolution;s in proposed in this work. This liquor were obtained from the ammoniac-carbonate process of Comandante Ernesto Che Gevara factory in Moa. Once the cobalt (III) hydroxide is obtained, it's characterized by means of different analytical techniques live: X rays diffraction , X rays fluorescence and differential thermal analysis. Besides, the solid activity per cent obtained in the synthesis is determined by means of a method proposed by the C.I.L. [ABSTRACT FROM AUTHOR]

One method for the synthesis of cobalt(III) hydroxide of industrial liquors from the cobalt and nickel sulfide dissolutions in proposed in this work. This liquor were obtained from the ammoniac-carbonate process of Comandante Ernesto Che Guevara factory in Moa. Once the cobalt(III) hydroxide is obtained, it's characterized by means of different analytical techniques live: X rays diffraction, X rays fluorescence and differential thermal analysis. Besides, the solid activity per cent obtained in the synthesis is determined by means of a method proposed by the CIL. [ABSTRACT FROM AUTHOR]