1. Adenoviruses isolated from wild gorillas are closely related to human species C viruses.
- Author
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Duncan, McVey, Cranfield, Michael R., Torano, Holly, Kuete, Hubert M., Lee, Grace P., Glenn, Andrew, Bruder, Joseph T., Rangel, David, Brough, Douglas E., and Gall, Jason G.
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ADENOVIRUSES , *GORILLA (Genus) , *CLADISTIC analysis , *DNA polymerases , *COXSACKIEVIRUSES ,REPRODUCTIVE isolation - Abstract
Abstract: We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors. [Copyright &y& Elsevier]
- Published
- 2013
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