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Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
- Source :
-
Neurobiology of Aging . Mar2016, Vol. 39, p195-201. 7p. - Publication Year :
- 2016
-
Abstract
- Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas ( Gorilla gorilla gorilla ) who were housed in American Zoos and Aquariums–accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas ( Gorilla beringei beringei ), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01974580
- Volume :
- 39
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Aging
- Publication Type :
- Academic Journal
- Accession number :
- 113374749
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2015.12.017