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Increased consumption of non-renewable energy sources, such as batteries, have led to increased environmental pollution and critical energy crises. Harvesting energy from vibration sources, using piezoelectric cantilevers, may be one of the main solutions to extending the life of the battery of some autonomous devices and either reducing or eliminating the need to replace them in service. This would make sensors self-powered, for instance. To minimize the volume of the Energy Harvester, a configuration with a circular frame supporting a radial set of bimorph piezoelectric beams with a proof mass at the tip is proposed. An analytic model is first developed to investigate the behavior of the electromechanical coupling, preliminarily sizing the design parameters, and to estimate the maximum power converted. A numerical model is then developed, in the COMSOL® Multiphysics software, to analyze all of the system details. Some FEM analyses allow for verifying the accuracy of the analytic model and predicting the dynamic system behavior under different load conditions. A critical issue in properly predicting the performance of such device is the electric circuit which is coupled to extract the charge produced. Therefore, the design of this read-out circuit is herein addressed. The LTspice XVII® software is then used to model the charge readout circuit. The electronic components interconnected within the circuit are first determined, and their electrical dynamic behavior is studied when coupled with the mechanical system. The efficiency of charge production and energy storage is evaluated by integrating the whole electromechanical system, including the readout circuit with the numerical model. The performance looks compatible with the required values proposed for some practical industrial applications, being also described. [ABSTRACT FROM AUTHOR]

In this article, the author shows that the equilibrium equations of any one-dimensional theory can be obtained by direct manipulation of the indefinite 3D elasticity equations: σ i j , i + p j = 0. It is found that there is no need to refer to Newton-type or Lagrange-type equations to write the equilibrium in terms of stress resultants. Such 'direct manipulation' is illustrated by considering various problems, from the simplest to the most complex. First, the bar case is analyzed and the well-known equilibrium normal stress resultant equation is obtained: N z z , z + q z = 0 ; second, the Timoshenko beam theory is tackled; finally, the case of arbitrary higher order beam theories based on the Carrera Unified Formulation is treated. The equations of a new, unprecedented higher-order beam theory are derived directly from the indefinite equilibrium equations as an example of the capabilities of the proposed method. The manipulation introduced consists of the following points: (i) the 3D elasticity is first written for each degree of freedom (dof) of the beam theories; (ii) the respective stress resultants are used to replace stress components in the latter equations; (iii) the derivatives on the beam axis z do not affect the nature of the indefinite equilibrium equations and these derivatives are applied directly to the respective stress resultants; (iv) the derivatives on the section coordinate x – y should 1 – change the sign of the respective stress resultants, 2 – be applied to the functions of x, y used to define the stress resultants. These points have been proved by referring to the principle of virtual work and splitting the differential operators of the strain-displacement relations into two parts: over the section derivatives along the beam axis derivatives. Some possible further generalizations are discussed in the appendix; in particular, the extension to is briefly discussed. [ABSTRACT FROM AUTHOR]

Background: Diastasis recti abdominis (DRA) is the separation of the rectus abdominis muscles along the linea alba, often occurring during pregnancy due to hormonal and mechanical changes. While DRA usually resolves post-childbirth, some women experience persistent issues. Exercise may help reduce the inter-rectus distance, though more research is needed. Objectives: Analyze the immediate and long-term effects of hypopressive and conventional abdominal exercises on inter-rectus distance (IRD) in postpartum women, focusing on parity differences. Methods: Twenty-eight women who met specific inclusion criteria were randomly assigned to either the hypopressive group (n = 14) or the conventional group (n = 14). The exercise programs for both groups lasted 6 weeks. Ultrasound measurements were taken of the IRD at two locations above the umbilicus, 2 cm (AB2) and 5 cm (AB5), before and after exercise programs. Results: The IRD decreased after both exercise programs compared to baseline measurements in AB2 (mean difference: 3.06 mm, 95% CI: 1.06 to 5.05) and in AB5 (mean difference: 2.88 mm, 95% CI: 1.59 to 4.17), confirming the long-term effect of exercise. No differences were found between the application of the conventional exercise program or the hypopressive exercises, indicating that both had a similar positive effect. Regarding the immediate effect, after the performance of both programs, the IRD was greater during rest compared to abdominal contraction. This effect was more pronounced at AB5 location (mean difference: 1.00mm, 95% CI: 0.97 to 1.89). Conventional exercises result in a reduction during resting condition (mean difference: 4.52mm, 95% CI: 2.62 to 6.79), whereas with hypopressive exercises, the reduction occurs during muscle contraction (mean difference: 3.43mm, 95% CI: 1.21 to 5.65). With regard to parity, multiparous women benefit most from the application of exercise programs. Conclusion: A reduction in IRD has been achieved with the implementation of both exercise programs in postpartum women, with multiparous women benefiting the most. Specifically, at 5 cm above umbilicus, conventional exercises result in a reduction during the rest condition, whereas with hypopressive exercises, the reduction occurs during muscle contraction. Trial registration: Clinical trial registration: NCT05439668. [ABSTRACT FROM AUTHOR]

Grains per spike in wheat (Triticum aestivum L.) are not uniformly distributed. Basal spikelets are typically sterile (or rudimentary) under common agronomic field conditions leading to the assumption that this is a constitutive trait. Yet, it is unknown whether high resource availability per plant could prevent floret mortality in basal spikelets. We present data from two field experiments assessing spike fertility in the four most basal spikelets of spikes from the main shoot and tillers. A collection of genotypes with different years of release and tillering habits were grown under contrasting sowing densities (agronomic densities versus isolated plants) to generate a condition of high assimilate supply to the spike. Under agronomic densities, the four most basal positions presented sterility in almost all cases in the main shoot spikes and without exception in the tiller spikes. When plants were isolated in each experiment, sterility in basal spikelets was absent and less frequent in spikes from the main shoot and tillers. Moreover, in the isolated condition, modern genotypes had a higher number of grains per spikelet than their older counterparts, whereas genotypes with low tillering habit showed the least response in spikelet fertility. These results indicate that while the predetermined lanceolate shape of spikes leads to the sterility of basal spikelets at high densities, this sterility can be reversed if assimilates become more available. Thus, sterility of basal spikelets in common agronomic conditions is not a constitutive condition of the spike. [ABSTRACT FROM AUTHOR]

Intrinsically colored cotton is crucial for sustainability as it eliminates the need for chemical dyes, reducing water pollution and carbon footprint. It also preserves biodiversity by using fewer pesticides and supports eco-friendly, ethical product creation. This research aims to examine the factors that influence the color change that occurs in naturally colored organic cotton (NaCOC) fabrics when washed under normal household conditions, and it focuses on special detergents designed for people with skin hypersensitivity. The study observes the impact of various washing conditions on the color changes of the fabrics. Specifically, three specific detergents, two types of water (tap and distilled), and three different temperatures (20, 40, and 60 °C) are taken into consideration as variables. By using colorimetric measures and correlating the results with the significant variables of the experimental design, the study evaluates how washing practices affect both the color and the overall integrity of the fabric. The findings demonstrate that the water hardness is the most influential variable when it comes to the color changes in the fabrics. Additionally, higher washing temperatures exacerbate color changes, particularly in hard water conditions. These results provide valuable insights for maintaining the color integrity of NaCOC fabrics during washing. [ABSTRACT FROM AUTHOR]

This paper presents a multi-dimensional variable-kinematics finite element model for nonlinear static analyses of structures with complex geometries. The approach incorporates higher-order beam models and classical solid finite elements in a unified framework, enabling refined modeling of complex geometries. The finite element procedure proposed follows the Carrera Unified Formulation (CUF) and uses a pure displacement-based methodology. The governing equations are derived within the classical continuum mechanics framework, and weak-form equilibrium equations are established using the Principle of Virtual Displacements (PVD). Within the CUF framework, higher-order beam and hexahedral solid models are defined in a unified manner, and the governing equations are written in terms of invariants of mathematical models used and the theory of structures approximation. A coupling technique is used between the beam and solid elements at the nodal level using superposition. The capabilities of fully nonlinear variable-kinematics models are investigated for the static analysis of various rectangular and curved structures. The numerical results are compared with solutions obtained using commercial software. Finally, the proposed methodology is applied to analyze more complex geometries in engineering applications. The results show the capabilities of variable-kinematics models in terms of both accuracy and computational efficiency for the computation of highly nonlinear deformed states and localized phenomena, such as stress concentrations and buckling. [ABSTRACT FROM AUTHOR]

Knowing the morphogenesis of forage species is an essential condition for the correct management of grazing in arid environments. Our aim was to define cardinal temperatures and morphogenetic characters for Poa ligularis and Bromus pictus, the most preferred and endangered Patagonian grass species. We grew plants in growth chambers at different temperatures under adequate water and nutrient supply. Our results were similar to those reported for other temperate species: base temperatures: 0°C, optimal temperatures: ≈22°C and maximum temperatures: ≈27.5°C for both species, and phyllochrons: 212.8 and 222.2 GDD (growing degree days), leaf appearance rates (LAR): 0.0047 and 0.0045 leaves.GDD−1, number of living leaves (NLL): 2.7 and 2.9 per tiller and leaf lifespan (LLS): 582 and 662 GDD, for P. ligularis and B. pictus, respectively. Cardinal temperatures, LAR and phyllochron did not differ between these species but NLL and LLS were lower for P. ligularis than for B. pictus. Results shown these species are similar to other temperate grasses under non-limiting water and nutrient conditions. These findings are the first step to propose field experiments that allow the accurate estimation of grazing and resting times in order to avoid consumption of unexpanded leaves and allow tillers to attain their maximum NLL. [ABSTRACT FROM AUTHOR]

The components of the mediator kinase module are highly conserved across all eukaryotic lineages, and cyclin‐dependent kinase 8 (CDK8) is essential for correct cell proliferation and differentiation in diverse eukaryotic systems. We show that CDK8 couples leaf development with the establishment of correct stomata patterning for prevailing CO2 conditions. In Arabidopsis, the basic helix‐loop‐helix (bHLH) transcription factor SPEECHLESS (SPCH) controls cellular entry into the stomatal cell lineage, and CDK8 interacts with and phosphorylates SPCH, controlling SPCH protein levels and thereby also expression of the SPCH target genes encoding key regulators of cell fate and asymmetric cell divisions. The lack of the CDK8‐mediated control of SPCH results in an increased number of meristemoid and guard mother cells, and increased stomata index in the cdk8 mutants. Increasing atmospheric CO2 concentrations trigger a developmental programme controlling cell entry into stomatal lineage by limiting the asymmetric divisions. In cdk8, the number of meristemoids and guard mother cells remains the same under ambient and high CO2 concentrations, as the accumulated levels of SPCH caused by the lack of CDK8 appear to override the negative regulation of increased CO2. Thus, our work provides novel mechanistic understanding of how plants alter critical leaf properties in response to increasing atmospheric CO2. Summary Statement: The components of the mediator kinase module are highly conserved across eukaryotic lines and cyclin‐dependent kinase 8 (CDK8) is essential for correct cell proliferation and development. We show here that control of leaf development is closely linked to the establishment of correct stomata patterning through the impact of CDK8. Comprehending the plasticity of plant morphology and the mechanisms behind it is essential for our understanding of plant environmental responses and the consequences of climate change. [ABSTRACT FROM AUTHOR]

AbstractThis paper investigates the effects of different materials on the dynamic properties of thin-walled metamaterial structures. The study focuses on changes in natural frequency and associated modal shapes as external load, either in-plane or transverse, increases. Central to the discussion is an analysis of the evolution of the bandgap, defined as the frequency interval between two consecutive vibrational modes; this is a critical dynamic property that informs the design of structural metamaterials. The numerical models of these complex structures are developed using the Carrera Unified Formulation (CUF), enabling the modeling of such structures with one-dimensional (1D) finite elements while still capturing three-dimensional (3D) effects. This approach allows for the use of the full 3D Green-Lagrange strain tensor in formulating the nonlinear governing equations, which significantly reduces the computational cost compared to traditional 3D finite elements and overcomes the limitations and nonlinear assumptions inherent in two-dimensional (2D) finite elements. The results demonstrate that different materials influence the dynamic response and bandgap evolution of the structures under increasing external loads. Specifically, various combinations and patterns of materials are analyzed, and the nonlinear dynamic behavior is examined for each case. These findings provide valuable insights for the design of metamaterials with specific bandgap characteristics. A similar behavior is observed in the nonlinear dynamic analysis of the sandwich structure. However, as this structure is much stiffer than the thin-walled case described above, the nonlinear effects on the dynamic response and bandgap evolution are less prominent. [ABSTRACT FROM AUTHOR]

AbstractThe present paper proposes new, improved one-dimensional finite elements that use the node-dependent kinematics method, i.e. each node may adopt a different expansion over the cross-section without using a special coupling method. Furthermore, the presented method is able to choose independent models for each of the three displacement variables. In particular, Taylor-based and Lagrange-based functions have been chosen as expansions for the cross-sections. These two outcomes are possible through the use of the Carrera Unified Formulation, which subdivides the three-dimensional displacement field into a cross-section domain and an axis domain. Starting from the principle of virtual displacements, the governing equations and finite element matrices are obtained. In numerical results, compact and thin-walled beams have been studied and subjected to various loading conditions, including bending and torsion-bending. The selected cases are compared with existing literature or with high-refined CUF-based solutions. The accuracy of the models presented is assessed for both displacements and stress components. The results show that the choice of the ‘best’ computational models in terms of accuracy vs degree of freedom is problem-dependent. Finally, the Node-dependent kinematics method permits the selection of the most suitable expansions for each cross-section. [ABSTRACT FROM AUTHOR]

This research problem is an investigation of reflection amplitude in a nonlocal porous-thermo-micropolar diffusion half-space under memory dependent derivative (MDD) thermo-elasticity subjected to impedance boundary reflecting surface. The governing equations for nonlocal porous-thermo-micropolar diffusion medium in MDD theory are formulated. This research challenge is solved analytically for a two-dimensional model in order to demonstrate the presence of four coupled longitudinal waves and two paired transverse waves denoted as coupled longitudinal displacement wave ( cLDW − I ), coupled longitudinal thermal wave ( cLDW − II ), coupled longitudinal mass diffusion wave ( cLDW − III ), coupled longitudinal void volume fraction wave ( cLDW − IV ), and coupled transverse displacement wave ( cTDW ) and coupled transverse micro-rotational wave ( cTMW ). When there is nonlocality, diffusion, and porous characteristics in the medium, it is discovered to have an impact on these coupled longitudinal waves, making them dispersive and attenuating. The transverse wave is non-attenuating but dispersive, it is unaffected by diffusion and porous characteristics. To find the expression for the reflection coefficients of reflected waves, the plane wave reflection from a thermally insulated surface subjected to an impedance boundary is explored. For a specific material, the reflection coefficients of the reflected waves are calculated, and graphic representations of the fluctuations of the reflection coefficients versus the incidence angle, nonlocality, diffusion and porous constants are provided. For further investigation, energy ratio can be studied in future. [ABSTRACT FROM AUTHOR]

Attachment and Biobehavioral Catch‐up (ABC) is an evidence‐based early intervention promoting attachment security and self‐regulation by enhancing parental sensitivity. When scaling up an evidence‐based intervention to the community, it is essential to consider families’ preferences and cultural values to ensure cultural appropriateness, while maintaining fidelity to the intervention's core components. In this article, we aimed to test the effectiveness of ABC in improving parental sensitivity when implemented in Spanish at a community level in the USA. The effectiveness of ABC when implemented in Spanish in the community was assessed through pre‐post changes in observed parental sensitivity in 79 Latine families with children ages 6 months to 4 years. Parental sensitivity increased from pre‐ to post‐test, with a similar effect size to previous studies (d = .67). Results and practice implications are discussed, highlighting the importance of the support to providers reaching families of diverse origins. [ABSTRACT FROM AUTHOR]

In this article, we offer a framework for understanding the role that racial group consciousness (RGC) plays in influencing Black Americans' engagement in costly political action. Attempting to add clarity to decades of inconsistent and at times contradictory findings, we argue that the effect of RGC at inspiring political action among Black Americans is conditional on (1) the relevance of the political activity to achieving a well-recognized racial group outcome and (2) individual capacity to assume the cost of engaging in the activity. Analyzing data from the ANES and two behavioral experiments, we find that RGC exhibits a consistently strong relationship with engagement in low-cost political behavior, regardless of whether the behavior has some explicit group-relevant outcome. When engagement becomes more costly, however, Blacks high in RGC are only willing to assume these costs if the engagement has some clear potential for racial group benefit. [ABSTRACT FROM AUTHOR]

In this study, the synthesis of a long-chain aliphatic amino compound and its sour corrosion inhibition properties were reported. Oleylamine was obtained through the reaction of 4-(Aminomethyl) pyridine with 1-chloro-octadecane. The identification and characterization of reaction products were carried out through Fourier transform infrared spectroscopy (FTIR) and gas chromatography/mass spectroscopy (GC-MS). Oleylamine was tested as a sour corrosion inhibitor for steels. Different concentrations of oleylamine (0, 5, 10, 25, and 100 ppm) in a sour saline electrolyte were analyzed. The dynamic anticorrosive behavior of oleylamine on carbon mild steel (AISI 1018) surfaces was evaluated using a laminar flow of 100 rpm and tested with potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) measurements. After electrochemical testing, the surface of the steel specimens that were used was characterized with Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The electrochemical results of the anticorrosive efficiency of oleylamine for steel showed an exponential behavior as a function of inhibitor concentration. At a concentration of 20 ppm of the inhibitor, the anticorrosive efficiency did not show any significant changes. However, at 100 ppm of the inhibitor, an efficiency of over 95% was achieved. After the electrochemical tests, the surface of the steel samples with the inhibitor revealed the formation of an inhibitor layer that prevented the corrosion of the steel. [ABSTRACT FROM AUTHOR]

Purpose: Myelomeningocele (MMC) is a prevalent neural tube closure defect often associated with hydrocephalus, necessitating surgical intervention in a significant proportion of cases. While ventriculoperitoneal shunting (VPS) has been a standard treatment approach, endoscopic third ventriculostomy (ETV) has emerged as a promising alternative. However, factors influencing the success of ETV in MMC patients remain uncertain. This retrospective observational study aimed to identify clinical and radiological factors correlating with a higher success rate of ETV in MMC patients. Methods: Medical records of MMC patients who underwent ETV at a tertiary care center between 2015 and 2021 were reviewed. Demographic, clinical, and radiological data were analyzed. ETV success was defined as the absence of further hydrocephalus treatment during follow-up. Results: Of 131 MMC patients, 21 met inclusion criteria and underwent ETV. The overall success rate of ETV was 57.1%, with a six-month success rate of 61.9%. Age ≤ 6 months was significantly associated with lower ETV success (25%) compared to older patients (76.9%) (OR: 0.1; 95% CI 0.005–2.006; p = 0.019). Radiological factors, including posterior fossa dimensions and linear indices, did not exhibit statistically significant associations with ETV success. Conclusion: Age emerged as a significant factor affecting ETV success in MMC patients, with younger patients exhibiting lower success rates. Radiological variables did not significantly influence ETV outcomes in this study. Identifying predictors of ETV success in MMC patients is crucial for optimizing treatment strategies and improving patient outcomes. [ABSTRACT FROM AUTHOR]

ABSTRACT Objectives Methods Results Conclusion Clinical Significance To report on soft tissue contour changes at pontic sites with or without soft tissue grafting over an observation period of 15 years.Fourteen patients received a fixed dental prosthesis (FDP) in the posterior zone in a controlled clinical study and were available at the 15‐year follow‐up. Eight patients received a subepithelial connective tissue graft in the pontic area (test) while six received the FDP without soft tissue grafting (control). Impressions were taken after FDP cementation and at 15 years. Casts were digitized and a profilometric analysis was performed (mean distance) and the pontic height (PH) and ridge width (RW) were analyzed at the mid‐buccal area. A descriptive analysis and Wilcoxon‐Mann–Whitney test was performed (level of significance: 5%).Profilometric changes (mean distance) from baseline to 15 years amounted to −0.68 mm (test) and to −0.33 mm (control) (p = 0.208), 95% CI for group difference (0.290; −0.750). PH measured −0.47 mm (test) and 0.0 mm (control) (p = 0.079) and RW amounted to −1.05 mm (test) and −0.38 mm (control) (p = 0.138).Remodeling of the soft tissue contour at pontic sites of FDPs was evident in both groups, but slightly more accentuated following soft tissue grafting.This study is the first to report on soft tissue changes at pontic sites over more than 10 years. It investigates whether tissue contour changes with and without soft tissue grafting before the insertion of FDPs. Remodeling of the soft tissue contour at pontic sites was observed over 15 years, with more pronounced changes when soft tissues were augmented with SCTGs before FDP insertion. The volume loss at the augmented site must be considered in relation to the overall tissue changes over long periods. Connective tissue grafts reliably improve shape and esthetics around the pontic unit. Further long‐term studies with more patients are needed to evaluate the initial gains and long‐term performance of these augmentations. [ABSTRACT FROM AUTHOR]

Dynamic combinatorial chemistry (DCC) creates libraries of molecules that are constantly interchanging in a dynamic combinatorial library. When a library member self‐assembles, it can displace the equilibria, leading to emergent phenomena like its selection or even its replication. However, such dynamic combinatorial libraries typically operate in or close to equilibrium. This work introduces a new dynamic combinatorial chemistry fueled by a catalytic reaction cycle that forms transient, out‐of‐equilibrium peptide‐based macrocycles. The products in this library exist out of equilibrium at the expense of fuel and are thus regulated by kinetics and thermodynamics. By creating a chemically fueled dynamic combinatorial library with the vast structural space of amino acids, we explored the liquid‐liquid phase separation behavior of the library members. The study advances DCCs by showing that peptide structures can be engineered to control the dynamic library′s behavior. The work paves the way for creating novel, tunable material systems that exhibit emergent behavior reminiscent of biological systems. These findings have implications for the development of new materials and for understanding life′s chemistry. [ABSTRACT FROM AUTHOR]

In der dynamischen kombinatorischen Chemie (DCC) werden Bibliotheken von Molekülen erzeugt, die sich in einer dynamischen kombinatorischen Bibliothek ständig verändern. Wenn sich ein Mitglied der Bibliothek selbst zusammenlagert, kann es die Gleichgewichte verschieben, was zu neuen Phänomenen wie Selektion oder sogar Replikation führt. Solche dynamischen kombinatorischen Bibliotheken arbeiten jedoch in der Regel im oder nahe am Gleichgewicht. In dieser Arbeit wird eine neue dynamische kombinatorische Chemie vorgestellt, die durch einen katalytischen Reaktionszyklus angetrieben wird, der transiente Makrozyklen auf Peptidbasis außerhalb des Gleichgewichts bildet. Die Produkte in dieser Bibliothek existieren außerhalb des Gleichgewichts auf Kosten eines Energieträgers und werden daher durch Kinetik und Thermodynamik reguliert. Durch die Schaffung einer chemisch regulierten dynamischen kombinatorischen Bibliothek mit dem riesigen Strukturangebot der Aminosäuren haben wir das Flüssig‐Flüssig‐Phasentrennungsverhalten der Bibliotheksmitglieder untersucht. Diese Studie bringt DCCs hervor, deren Peptidstrukturen so gestaltet werden können, dass sie das Verhalten der dynamischen Bibliothek steuerbar machen. Die Arbeit ebnet den Weg für neuartige, kontrollierbare Materialsysteme, die Verhalten und Eigenschaften zeigen, die an biologische Systeme erinnern. Diese Erkenntnisse sind relevant für die Entwicklung neuartiger Materialien und für das Verständnis über die Chemie des Lebens. [ABSTRACT FROM AUTHOR]

Background: Dengue is a serious public health problem worldwide, including Panama. During the last years, the number of dengue cases has increased. This may be due to the presence of mosquito populations resistant to insecticides. The aim of this study was to characterize the resistance status, its enzymatic mechanisms and Kdr mutations in wild populations of Aedes aegypti and Aedes albopictus. Methods: Standard WHO bioassays were performed using insecticide-treated filter papers to determine resistance in populations Ae. aegypti and Ae. albopictus to pyrethroids insecticides, organophosphates, to the carbamate propoxur and to the organochlorine DDT. Biochemical assays were conducted to detect metabolic resistance mechanisms and real-time PCR was performed to determine the frequencies of the Kdr mutations Val1016IIe and F1534C. Results: The strains Ae. aegypti El Coco showed confirmed resistance to deltamethrin (78.5% mortality) and lambda-cyhalothrin (81%), Aguadulce to deltamethrin (79.3%), David to deltamethrin (74.8%) and lambda-cyhalothrin (87.5%) and Puerto Armuelles to permethrin (83%). Aedes aegypti El Empalme showed confirmed resistance to pirimiphos-methyl (62.3% mortality), chlorpyrifos-methyl (55.5%) and propoxur (85.3%). All strains of Ae. albopictus showed possible resistance to PYs and five strains to DDT. Only Ae. albopictus Canto del Llano showed confirmed resistance to pirimiphos-methyl (70% mortality) and malathion (62%). Esterase activity was variable across sites with the most frequent expression of α-EST compared to β-EST in Ae. aegypti populations. In Ae. Albopictus, the expressed enzymes were β-EST and MFOs. Through ANOVA, significant differences were established in the levels of enzymatic activity of α- and β-EST, MFOs and GST, with p < 0.001 in the Ae. aegypti and Ae. albopictus. The Kdr Val1016IIe mutation was detected in Ae. aegypti Aguadulce, El Coco and David. The odds ratio for the Val1016Ile mutation ranged from 0.8 to 20.8 in resistant mosquitoes, indicating the association between pyrethroid phenotypic resistance and the kdr mutation. Conclusion: The presence of a varied and generalized resistance, enzymatic mechanisms and the Val1016IIe mutation may be associated with the intensive use and possibly misuse of the different insecticides applied to control Aedes populations. These results highlight the need to develop a program for resistance management. Also, alternative approaches to mosquito control that do not involve insecticides should be explored. [ABSTRACT FROM AUTHOR]

One of the legacies of the Apollo missions and the fleet of unmanned probes that have followed them is the recognition that the Moon is far more active than previously believed, with seismic activity deep in the lunar interior and some tectonic activity at shallower depths, as well as gas release from below the surface. Here, we review lunar activity in the context of reports of the observation of transient lunar phenomena (TLPs), attempting to separate myth from reality. We suggest that a significant fraction of reported TLPs could have an explanation in local geology or geomorphology. In a further paper we will examine one particularly well-known TLP report to see if there is a plausible explanation based on local geology. [ABSTRACT FROM AUTHOR]

Genetic diversity is heterogeneously distributed among populations of the same species, due to the joint effects of multiple demographic processes, including range contractions and expansions, and mating systems shifts. Here, we ask how both processes shape genomic diversity in space and time in the classical Primula vulgaris model. This perennial herb originated in the Caucasus region and was hypothesized to have expanded westward following glacial retreat in the Quaternary. Moreover, this species is a long-standing model for mating system transitions, exemplified by shifts from heterostyly to homostyly. Leveraging a high-quality reference genome of the closely related Primula veris and whole-genome resequencing data from both heterostylous and homostylous individuals from populations encompassing a wide distribution of P. vulgaris , we reconstructed the demographic history of P. vulgaris. Results are compatible with the previously proposed hypothesis of range expansion from the Caucasus region approximately 79,000 years ago and suggest later shifts to homostyly following rather than preceding postglacial colonization of England. Furthermore, in accordance with population genetic theoretical predictions, both processes are associated with reduced genetic diversity, increased linkage disequilibrium, and reduced efficacy of purifying selection. A novel result concerns the contrasting effects of range expansion versus shift to homostyly on transposable elements, for the former, process is associated with changes in transposable element genomic content, while the latter is not. Jointly, our results elucidate how the interactions among range expansion, transitions to selfing, and Quaternary climatic oscillations shape plant evolution. [ABSTRACT FROM AUTHOR]

Background. Mansoa alliacea is a native plant renowned for its medicinal properties in traditional healing in the Amazon Region. This plant is rich in polyphenols, flavonoids, anthocyanins, phenolic acids, tannins, ketones, triterpenes, as well as other bioactive compounds. Objectives. This study aims to develop an innovative, eco-friendly method for synthesizing silver nanoparticles using an aqueous extract of M. alliacea (Ma-AgNPs), enhancing the biological activities of AgNPs by leveraging the therapeutic potential of the plant's bioactive compounds. Methods. Silver nanoparticles were synthesized using the aqueous extract of M. alliacea. The biological activities of Ma-AgNPs were assessed, including antibacterial, anti-inflammatory, antioxidant, antitumor, and anti-biofilm effects, along with evaluating their hemolytic activity. Results. Quantitative analysis revealed that Ma-AgNPs exhibit potent antibacterial activity against multidrug and non-multidrug-resistant bacteria, with MIC values ranging from 1.3 to 10.0 µg/mL. The Ma-AgNPs significantly reduced NO production by 86.9% at 4 µg/mL, indicating strong anti-inflammatory effects. They demonstrated robust antioxidant activity with an IC50 of 5.54 ± 1.48 µg/mL and minimal hemolytic activity, with no hemolysis observed up to 20 µg/mL and only 4.5% at 40 µg/mL. Their antitumor properties were notable, with IC50 values between 2.9 and 5.4 µg/mL across various cell lines, and they achieved over 50% biofilm inhibition at concentrations of 30–40 µg/mL. Conclusions. These findings underscore the potential of Ma-AgNPs for biomedical applications, particularly in developing new antimicrobial agents and bioactive coatings with reduced toxicity. This research highlights a sustainable approach that not only preserves but also amplifies the inherent biological activities of plant extracts, paving the way for innovative therapeutic solutions. [ABSTRACT FROM AUTHOR]

The characterization of passive area sources, emitting odours due to wind-driven convection, poses significant challenges. The present experimental study aims to evaluate the performance, in terms of fluid dynamics and mass transfer, of a recently developed wind tunnel, with a more compact design and reduced weight, compared to the one proposed by the Italian regulations. The results show that the new design outperforms the Italian standard in several aspects. From a fluid dynamic point of view, the new wind tunnel exhibits a slightly more homogenous and uniform velocity distribution, and it does not reveal airflow preferential channels inside the central body. The pressure tests highlight that the presence of fillers in the new wind tunnel does not significantly alter the pressure inside the hood and therefore the gas–liquid equilibrium conditions; actually, the slight overpressure may help to prevent the infiltration of external air. Finally, mass transfer tests on the standard device show a vertical concentration gradient along the outlet duct, highlighting concentration values that differ up to a factor of two depending on the measurement point. The new design has almost completely solved this issue, thanks to the use of fillers that promote mixing of the outlet flow. [ABSTRACT FROM AUTHOR]

The primary module of Quality Function Deployment (QFD) is the House of Quality (HoQ), which supports the design of new products and services by translating customer requirements (CRs) into engineering characteristics (ECs). Within the HoQ framework, the traditional technique for prioritizing ECs is the independent scoring method (ISM), which aggregates the weights of the CRs and the relationships between CRs and ECs (i.e., null, weak, medium, and high) through a weighted sum. However, ISM incorporates two questionable operations: (i) an arbitrary numerical conversion of the relationships between CRs and ECs, and (ii) the "promotion" of these relationships from ordinal to cardinal scale. To address these conceptual shortcomings, this paper introduces a novel procedure for prioritizing ECs, inspired by the Thurstone's Law of Comparative Judgment (LCJ). This procedure offers a solution that is conceptually sound and practical, overcoming the conceptual shortcomings of ISM, while maintaining its simplicity, flexibility, and ease of implementation. The proposed approach is supported by a realistic application example illustrating its potential. [ABSTRACT FROM AUTHOR]

Objectives: Experimental and small human studies have indicated that high total adiponectin levels have beneficial cardiometabolic effects. In contrast, however, high total adiponectin levels are also associated with higher all‐cause and cardiovascular mortality in thoroughly adjusted epidemiological studies. To gain further insight into these seemingly contradictory results, we report results on total adiponectin from the indigenous Melanesian population of Kitava, Trobriand Islands, Papua New Guinea, where an apparent absence of cardiometabolic disease has been previously reported. Methods: Fasting levels of serum total adiponectin were measured cross‐sectionally in ≥40‐year‐old Kitavans (n = 102) and Swedish controls matched for age and sex (n = 108). Multivariable linear regression was used for the analysis of associations with total adiponectin when controlled for group, sex, smoking, hypertension and/or type 2 diabetes, age, and body mass index. Results: Total adiponectin was lower for Kitavans compared to Swedish controls (Median [Mdn] 4.6 μg/mL, range 1.0–206 μg/mL and Mdn 9.7 μg/mL, range 3.1–104 μg/mL, respectively, r =.64, p <.001). Lower total adiponectin was associated with Kitavan group, male sex (only in Swedish controls), smoking (only in Kitavans and Swedish controls combined), younger age (not in Swedish controls), higher BMI, lower total, low‐density lipoprotein, high‐density lipoprotein (HDL) (only in Kitavans and Swedish controls combined), and non‐HDL cholesterol, and higher anti‐PC IgG (only in Kitavans and Swedish controls combined). Conclusion: Total adiponectin in Kitavans was significantly lower than in Swedish controls. [ABSTRACT FROM AUTHOR]

The HNF1B gene, located on chromosome 17q12, encodes a transcription factor essential for the development of several organs. It regulates the expression of multiple genes in renal, pancreatic, hepatic, neurological, and genitourinary tissues during prenatal and postnatal development, influencing processes such as nephrogenesis, cellular polarity, tight junction formation, cilia development, ion transport in the renal tubule, and renal metabolism. Mutations that alter the function of Hnf1b deregulate those processes, leading to various pathologies characterized by both renal and extrarenal manifestations. The main renal diseases that develop are polycystic kidney disease, hypoplastic or dysplastic kidneys, structural abnormalities, Congenital Anomalies of the Kidney and Urinary Tract (CAKUT), and electrolyte imbalances such as hyperuricemia and hypomagnesemia. Extrarenal manifestations include Maturity-Onset Diabetes of the Young (MODY), hypertransaminasemia, genital and urinary tract malformations, Autism Spectrum Disorder (ASD), and other neurodevelopmental disorders. Patients with HNF1B alterations typically carry either punctual mutations or a monoallelic microdeletion in the 17q12 region. Future research on the molecular mechanisms and genotype–phenotype correlations in HNF1B-related conditions will enhance our understanding, leading to improved clinical management, genetic counseling, monitoring, and patient care. [ABSTRACT FROM AUTHOR]

Warm night frequency has increased steadily in the last years across maize production regions, but high night temperature (HNT) effects on growth, grain yield and maize dry matter allocation (DMA) to different plant organs remain poorly understood. In this study, we aimed to (i) analyse the DMA among reproductive and vegetative organs, (ii) evaluate the individual kernel weight through its determinants, rate and duration of grain filling and (iii) quantify changes in grain yield per plant and its components due to HNT during the postflowering and early grain‐filling period. Field‐grown maize was subjected to HNT induced by shelters during a 15‐ or 30‐day period after silking, encompassing the postflowering period (HNT15) and extending the heating into early grain filling (HNT30), respectively. The HNT was applied from 1900 to 0700 h while control plots remained at ambient night temperature (ANT). Kernel number per plant was decreased under both temperature regimes (i.e., HNT15 and HNT30); however, significant reductions in grain yield were only observed under HNT30. The DMA during the heating period was differentially affected by the duration of heating. While DMA to the stem was likewise reduced by both heating treatments, the partition to the uppermost ear was only reduced under HNT30. Related to the lack of response to HNT treatments of the rate and duration of grain filling, the individual kernel weight was not reduced. The source‐sink ratio was not affected by HNT, meanwhile, the apparent reserve use was significantly reduced under HNT30. Our results demonstrate that the magnitude of HNT effects is subjected to the duration of the heating period, but also depends on the intensity of heating explored across seasons, especially for kernel number and grain yield. [ABSTRACT FROM AUTHOR]

Latin American countries have been at the forefront of pension privatization and since 2008 they have also pioneered reform reversals. Previous studies have focused on single cases or a small number of them, given that pension reform is a complex phenomenon arising from the combination of different causes. Using fuzzy-set Qualitative Comparative Analysis (fsQCA), the article analyzes a set of 32 pension reform cases in eight countries from the early 1990s until 2021. It finds four different pathways that combine institutional, structural and policy legacy conditions. It demonstrates that fsQCA is a useful tool for broader comparative policy work. [ABSTRACT FROM AUTHOR]

KNJ is the category of compact normal joinfit frames and frame homomorphisms. P F is the complete boolean algebra of polars of the frame F. A function X that assigns to each F ∈ KNJ a subalgebra X (F) of P F that contains the complemented elements of F is a polar function. A polar function X is invariant (resp., functorial) if whenever ϕ : F ⟶ H ∈ KNJ is P -essential (resp., skeletal) and p ∈ X (F) , then ϕ (p) ⊥ ⊥ ∈ X (H) . ϕ : F ⟶ H ∈ KNJ is X -splitting if ϕ is P -essential and whenever p ∈ X (F) , then ϕ (p) ⊥ ⊥ is complemented in H. F ∈ KNJ is X -projectable means that every p ∈ X (F) is complemented. For a polar function X and F ∈ KNJ , we construct the least X -splitting frame of F. Moreover, we prove that if X is a functorial polar function, then the class of X -projectable frames is a P -essential monoreflective subcategory of KNJS , the category of KNJ -objects and skeletal maps (the case X = P is the result from Martínez and Zenk, which states that the class of strongly projectable KNJ -objects is a reflective subcategory of KNJS ). [ABSTRACT FROM AUTHOR]

Antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics in the face of ever-increasing resistance. However, many AMPs fail to progress into clinics due to unexpected difficulties found in preclinical in vivo phases. Our research has focused on crotalicidin (Ctn), an AMP from snake venom, and a fragment thereof, Ctn[15-34], with improved in vitro antimicrobial and anticancer activities and remarkable serum stability. As the retroenantio versions of both AMPs maintained favorable profiles, in this work, we evaluate the in vivo efficacy of both the native-sequence AMPs and their retroenantio counterparts in a murine infection model with Acinetobacter baumannii. A significant reduction in bacterial levels is found in the mice treated with Ctn[15-34]. However, contrary to expectations, the retroenantio analogs either exhibit toxicity or lack efficacy when administered to mice. Our findings underscore the critical importance of in vivo infection model evaluation to fully calibrate the therapeutic potential of AMPs. [ABSTRACT FROM AUTHOR]

Here, an analytical form Navier solution for higher-order micropolar theory of cylindrical shell was developed based on the CUF approach. The cases of complete linear expansion and model based on Timoshenko-Mindlin shear deformation hypothesis are considered in detail. The two-dimensional system of differential equations obtained here using the principle of virtual displacements for the theory of micropolar elastic cylindrical shell of a higher order is solved here for the case of freely supported cylindrical shell using the Navier variable separation method. Some numerical examples were performed and the influence of the rotational field, as well as the micropolar couple stress on the stress–strain state, was analyzed. The equations presented here can be used for the stress–strain calculation and for thin-walled structures modeling in macro-, micro-, and nanoscale, with considering effects of micropolar couple stress and rotation. [ABSTRACT FROM AUTHOR]

This exploratory study analyzes the mechanisms and barriers through which the Port State Control (PSC) regimes can promote or undermine a safety learning culture. PSC Officers (PSCOs), ideally positioned to collect ship data, have the potential to significantly enhance safety learning at national and global levels. The study, which involved semi-structured interviews with eleven seafarers and twenty PSCOs from China, underscores the inherent potential of PSC regimes to enhance safety and promote ship safety. This might be achieved through the establishment of mutually beneficial relationships with crew members, companies, and other maritime stakeholders, including regulators at national and international levels. However, the quality and diversity of ship feedback depend on seafarers’ willingness or reluctance to contribute. The paper concludes with actionable recommendations, including promoting trustful interactions during inspections, enhancing non-technical skills for PSCOs and in-depth safety assessments. [ABSTRACT FROM AUTHOR]

7‐Azaindole has been integrated as building block with complementary N−H⋅⋅⋅N hydrogen bonding sites for the synthesis of a tetrahedral molecular tecton, namely tetra(α‐carbolin‐6‐yl)methane, TACM. The self‐assembly of this molecule results in a 3D hydrogen‐bonded organic framework (HOF). This supramolecular structure constitutes a crystalline microporous material with an extraordinary thermal and chemical robustness. Single crystal X‐ray diffraction reveals how the five‐fold catenation of diamonoid systems, stabilized by hydrogen bonds and π–π interactions, form an interpenetrated network with monodimensional channels. The structural features of the crystalline material are also observed by transmission electron microscopy (TEM). Additionally, the microporosity of the activated TACM‐HOF is characterized by gas sorption (N2, CO2, CH4 and H2) experiments performed at different pressures. A selective adsorption is observed for CO2 uptake and TACM‐HOF also presents a good adsorption capacity for H2 among supramolecular organic frameworks. [ABSTRACT FROM AUTHOR]

An efficient mode of evaluation for eye movements is the use of objective eye tracking systems combined with subjective tests (NSUCO or DEM), which are easily applicable across all age groups and in eye care clinical settings. The objective of this study was to characterize fixations during reading in two groups: a group of children with neurodevelopmental disorders (NDDG, 24 children, age: 6–12 years) and a group of children with oculomotor anomalies but without NDD (OAG, 24 children, age: 6–12 years). The results obtained were compared with those from a control group (CG, 20 children, age: 6–12 years). Specifically, the outcomes obtained with two subjective score systems, the Northeastern State University College of Optometry's Oculomotor (NSUCO) test and the Developmental Eye Movement (DEM) test, were compared with the objective analysis obtained through a commercially available eye tracker (Tobii Eye X, Tobii, Stockholm, Sweden). Specialized analysis software, namely Clinical Eye Tracker 2020 (Thomson Software Solutions, Welham Green, UK), was used. It was found that children with NDD had impaired oculomotor skills. A higher number of regressions, more fixations, and longer durations of fixations appear to be characteristic signs of this population group. Additionally, children with NDD took longer to complete the DEM test, as well as exhibiting more errors. The use of objective videoculographic systems for eye tracking and subjective tests like the NSUCO or DEM are good tools to assess saccadic movements, allowing the detection of oculomotor abnormalities in children with NDD. [ABSTRACT FROM AUTHOR]

In this paper we approach the linear mixed problem with initial and boundary values for a Cosserat body which is elastic and has pores. We coupled the equations characterizing the pores evolution with basic equations that describing the elastic deformations of the Cosserat body. The coupling is done by means of predetermined coefficients. To prove the continuous dependence of the solutions, we introduce an adequate measure which is useful in obtaining of some estimations with respect to the gradient of elastic deformations and regarding the gradient of a specific the application, introduced to characterize the behavior of the pores. [ABSTRACT FROM AUTHOR]

Previous research shows that being in a situation of economic scarcity promotes a more concrete mindset that motivates behavioral decisions based on action difficulty and their short‐term outcomes, which frequently entails negative consequences. However, a concrete mindset can be counteracted by inducing an abstract mindset to help people focus on final broad goals. We explored how focusing on transcendent motives (vs. self‐oriented) promotes a more abstract mindset facilitating prosocial behavioral intentions. Study 1 (pre‐post design) explored whether focusing on transcendent motives for engaging in activities promoted a more abstract mindset compared to focusing on self‐oriented motives. Using a 2 × 2 design with two consecutive opposing primes, Study 2 tested how inducing a transcendent orientation could reverse the effect caused by perceiving economic scarcity, promoting greater orientation toward others and prosocial behavioral intentions. In Study 1 participants who generated transcendent motives for behaviors presented a greater increase in the abstraction of construal level, compared to those who only generated self‐oriented motives for the same behaviors. Study 2 demonstrated that, when participants who perceived economic scarcity were focused on transcendent motives (vs. self‐oriented) to promote a more abstract mindset, their orientation toward others increased. Interestingly, for people perceiving economic scarcity, whose own difficulties could reduce prosocial behaviors, the greater orientation toward others promoted a greater intention to engage in demanding prosocial behaviors. We provide evidence of new strategies to promote abstraction in individuals and increase their involvement in prosocial behavioral intentions, especially for those perceiving economic scarcity. [ABSTRACT FROM AUTHOR]

Background: Plasmodium vivax is the main causative agent of malaria in Panama. However, the prevalence of asymptomatic infections in the different endemic regions remains unknown. Understanding the epidemiological behavior of asymptomatic infections is essential for the elimination of malaria. This study aimed to determine the prevalence of asymptomatic malarial infections in one of the main endemic regions of Panama using multiplex real-time reverse transcription RT-MqPCR. Methods: A cross-sectional study was conducted in three communities in the Guna Yala Comarca. A total of 551 thick blood smears and their respective samples on filter paper were collected from volunteers of different ages and sexes from June 20 to 25, 2016. Infections by the Plasmodium spp. were diagnosed using microscopy and RT-MqPCR. All statistical analyses were performed using the R software. Results: The average prevalence of asymptomatic infections by P. vivax in the three communities detected by RT-MqPCR was 9.3%, with Ukupa having the highest prevalence (13.4%), followed by Aidirgandi (11.1%) and Irgandi (3.3%). A total of 74 samples were diagnosed as asymptomatic infections using RT-MqPCR. Light microscopy (LM) detected that 17.6% (13/74) of the asymptomatic samples and 82.4% (61/74) were diagnosed as false negatives. A 100% correlation was observed between samples diagnosed using LM and RT-MqPCR. A total of 52.7% (39/74) of the asymptomatic patients were female and 85.1% (63/74) were registered between the ages of 1 and 21 years. Factors associated with asymptomatic infection were community (aOR = 0.38 (95% CI 0.17–0.83), p < 0.001) and age aOR = 0.98 (95% CI 0.97–1.00), p < 0.05); F = 5.38; p < 0.05). Conclusions: This study provides novel evidence of the considerable prevalence of asymptomatic P. vivax infections in the endemic region of Kuna Yala, representing a new challenge that requires immediate attention from the National Malaria Program. The results of this study provide essential information for the health authorities responsible for developing new policies. Furthermore, it will allow program administrators to reorient and design effective malaria control strategies that consider asymptomatic infections as a fundamental part of malaria control and move towards fulfilling their commitment to eliminate it. [ABSTRACT FROM AUTHOR]

AbstractThis article proposes a rigorous mathematical justification of the derivation of the governing equations of any beam and plate theory by the three three-dimensional (3D) elasticity equations. This is done by the application of the integration by part theorem via weight residual-like methods. The Fis polynomials (subscripts i and s denote the i-direction and the generic s-term of the displacement expansion uis, respectively) related to a given beam/plate theory are used as weight functions for each of the displacement unknown. To show how the method works a number of simple problems are discussed. These are related to the equilibrium equations and boundary conditions of bending beams according to shear deformation theory. Three methods for obtaining these equations are compared in some detail. The first two are the well-known methods used in mechanics of deformable bodies: (1) use of the Principle of Virtual Displacements; (2) use of the six cardinal ‘Newton’ equations of statics. The third method coincides with the one proposed and rigorously justified in this paper which is (3) the direct integration of the equations of 3D elasticity. Beam theories based on Lagrange polynomials are used as well. The latter makes it possible to immediately develop theories for layered beams and obtain so-called ‘layer-wise’ models, which are only applied here to the case of sandwich structures. Three appendixes discuss: A – The problem in which the derivative of one of the unknowns appears among the unknowns, as is the case with the Euler–Bernoulli theory; B – The extension to dynamics; C-Simple derivation of constitutive equations and related closed-form solution via Navier method. [ABSTRACT FROM AUTHOR]

Context. The dynamical evolution of open clusters is driven by stellar evolution, internal dynamics, and external forces, which according to dynamical simulations will lead to their evaporation over a timescale of about 1 Ga. However, about 10% of the known open clusters are older. These latter are special systems whose detailed properties are related to their dynamical evolution and the balance between mechanisms of cluster formation and dissolution. Aims. We investigated the spatial distribution and structural parameters of six open clusters older than 1 Ga in order to constrain their dynamical evolution and longevity. Methods. We identified members using Gaia EDR3 data up to a distance of 150 pc from the centre of each cluster. We investigated the spatial distribution of stars inside each cluster to understand their degree of mass segregation. Finally, in order to interpret the obtained radial density profiles, we reproduced them using the lowered isothermal model explorer with PYthon (LIMEPY) and the spherical potential escapers stitched (SPES) models. Results. All the studied clusters appear to be more extended than previously reported in the literature. The spatial distributions of three of them show some structures aligned with their orbits. These structures may be related to the existence of extra tidal stars. Moreover, we find that about 20% of their members have sufficient energy to leave the systems or are already unbound. Together with their initial masses, their distances to the Galactic plane may play significant roles in their survival. We find clear evidence that the most dynamically evolved clusters do not fill their Roche volumes, appearing more concentrated than the others. Finally, we find a cusp–core dichotomy in the central regions of the studied clusters, which shows some similarities to that observed among globular clusters. [ABSTRACT FROM AUTHOR]

Geocaching is an activity that involves hiding or finding treasures (geocaches) anywhere with the help of GPS or geolocation. This work consists of the design, development and evaluation of a socioeducational practice, using a mobile device as a tool and a geolocation application as an instrument. The aim of this study is to find out the impact of the implementation of an educational practice in the municipal context to raise environmental awareness and improve digital literacy using geolocation. This proposal is part of the socio-educational area in the information society, within the field of child protection, specifically in a day care centre for minors. This research is qualitative, in particular it is a multiple case study and is framed within the narrative approach. The results and conclusions show that the children and the professionals involved are satisfied with the implementation of the socio-educational practice in the municipal context, with entertainment predominating as a positive aspect. The children have acquired mainly procedural knowledge, with the support of digital technology. Finally, it is worth mentioning the impact on motivation and conflict resolution. [ABSTRACT FROM AUTHOR]

Background: Short‐term cognitive impairment is associated with SARS‐CoV‐2 infection but the long‐term impact is yet to be examined in detail. We aim to study the evolution of these symptoms in severe COVID‐19 patients admitted to the intensive care unit (ICU) between April and December 2020 1 year after hospital discharge and to analyze its clinical correlates. Method: A total of 58 patients agreed to participate in the 6 months follow‐up and 30 at 1 year after hospital discharge. Demographic, clinical and laboratory data were collected and a comprehensive neuropsychological battery including validated tests for the main cognitive domains was administered. To test the magnitude of neurocognitive sequelae, two standard deviations below normative group were considered. To compare the neuropsychological performance at 6 and 12 months follow‐up we used repeated measures tests. Finally, regression analyses were performed to test the main effects of medical and psychological factors on multiple cognition. Results: Almost half of the sample continued to have impaired performance on neuropsychological tests at 12 months follow‐up. In comparison with the results obtained at 6 months, significant improvements were found in immediate recall (d = 0.49), delayed recall (d = 0.45), and inhibitory control (d = 0.53). Medical variables predicted cognitive performance at 6 months but not at 12 months follow‐up, while anxiety and depression predicted cognitive deficits in the long‐term. Conclusions: A generalised improvement was observed in severe COVID‐19 patients at follow‐up. This improvement was particularly notable in verbal memory and executive functioning. However, a considerable proportion of the sample continued to present deficits at 1 year follow‐up. [ABSTRACT FROM AUTHOR]

The study aimed to evaluate the impact of two chain transfer controllers, ethyl 2-(phenylcarbonothiolthio)-2-phenylacetate (EPPA) and 2-(4-methoxyphenylcarbonothiolthio) ethanoic acid (MPEA), from the dithioester family (dithiobenzoates), on the RAFT polymerization of β-myrcene. The initiators employed were azobisisobutyronitrile (AIBN) or dicumylperoxide (DCP), at 65 °C and 90 °C, respectively. The study analyzed the impact of the type of controller, temperature, and initiator/controller ratio on the living nature of β-myrcene polymerization. The results showed that with an increase in the initiator/controller ratio, the rate of polymerization increased, but the obtained molar masses decreased. The MPEA controller showed better performance in controlling the termination and chain transfer reactions, especially when AIBN was used as the initiator. A rise in polymerization temperature led to a loss in the control of polymerization, causing an increase in the degree of polydispersity due to the presence of transfer reactions. The most effective control in the RAFT polymerization of β-myrcene was achieved using MPEA as the controller and AIBN as the initiator, resulting in a poly(β-myrcene) with 87% 1,4-addition according to proton NMR analyses and a polydispersity of 1.27 by gel permeation chromatography (GPC). Finally, the study synthesized a poly(β-myrcene)-b-poly(styrene) block copolymer with low polydispersity (Ð1.1) by sequentially adding styrene to the previously synthesized MPEA-poly(β-myrcene)-based RAFT macrocontroller. [ABSTRACT FROM AUTHOR]

Hydrotalcite-type compounds (HTs) are crystalline ion-exchange materials formed by positively charged sheets of metal hydroxides stabilized with interlayer anions. The synthesis methods significantly influence their crystallographic and morphological properties. Alternative methods, such as microwave or ultrasound irradiation, can reduce the synthesis time and obtain materials with specific characteristics. HT with the interlayer anion of NO3− was synthesized via conventional aging (hydrothermal), microwave, ultrasound, and combined (microwave/ultrasound) methods. The obtained compounds were characterized via X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM–EDS), N2 adsorption-desorption, Fourier-transform infrared spectroscopy (FTIR), and point of zero charge. A larger crystal size ( t = 5.9 nm) and a higher surface area ( S = 6.70 m2 g−1) were obtained when HT was irradiated by microwaves/ultrasound compared to the synthesized compound via hydrothermal aging ( t = 5.5 nm, S = 1.83 m2 g−1). Although the removal capacity of the combined-mode irradiated compound was slightly lower ( q max = 41.7 ± 4.8 mg g−1) than the conventionally aged sample ( q max = 44.4 ± 6.8 mg g−1), the synthesis time was drastically decreased from 24 h to 5 min, and the combined-mode irradiated compound could remove fluoride as efficiently as the compounds obtained conventionally. [ABSTRACT FROM AUTHOR]

The problems that arise with coexistence between schoolchildren are a challenge when it comes to carrying out the teaching–learning process. In recent years, the presence of bullying has increased in schools. The aim of this study is to identify the perceptions of teachers regarding the problems of coexistence among schoolchildren, more specifically concerning bullying, as well as to identify their position regarding the prevention of bullying. Research was carried out using a mixed approach. A total of 225 education professionals from different schools in Spain took part. From the results and our conclusions, it should be noted that teachers consider themselves to have a high level of knowledge of the essential characteristics of the dynamics of bullying, of the actors involved, and of some preventive measures that can be carried out to avoid this type of behaviour as much as possible. On the other hand, a large number of teachers downplay the importance of the problem of coexistence in their fields, and/or are not able to identify it, which makes it impossible to act. Some schools hardly carry out any prevention work, which makes it difficult to eradicate bullying. [ABSTRACT FROM AUTHOR]

Summary: Seed dormancy governs germination timing, with both evolutionary and applied consequences. Despite extensive studies on the hormonal and genetic control of these processes, molecular mechanisms directly linking dormancy and germination remain poorly understood.By screening a collection of lines overexpressing Arabidopsis transcription factors, we identified ERF50 as a key gene to control dormancy and germination. To study its regulation, we measured seed‐related physiological parameters in loss‐of‐function mutants and carried out transactivation, protein interaction and ChIP‐PCR analyses.We found direct ERF50‐mediated repression of DOG1 and activation of EXPA2 transcription, which results in enhanced seed germination. Although ERF50 expression is increased by DOG1 in dormant seeds, ERF50 germination‐promoting activity is blocked by RGL2.The physiological, genetic and molecular evidence gathered here supports that ERF50 controls germination timing by regulating DOG1 levels to leverage its role as enhancer of seed germination, via RGL2 antagonism on EXPA2 expression. Our results highlight the central role of ERF50 as a feedback regulator to couple and fine‐tune seed dormancy and germination. [ABSTRACT FROM AUTHOR]

Diarrhoea is a serious cause of mortality worldwide that can lead to dehydration, gut barrier function impairment, nutrient malabsorption, and alterations of the gut microbiota (dysbiosis). The current solutions for its management, such as oral rehydration salts (ORS), inhibitors of gut motility, antibiotics, and living probiotics, only partially counteract the mechanisms of the disease and do not provide a full coverage of the problem. The potential risks of the use of living probiotic strains, particularly in immunocompromised patients, can be eliminated with the use of tyndallized (heat-killed) postbiotic bacteria and yeast. ABB C22® is a postbiotic combination of three tyndallized yeasts, namely Saccharomyces boulardii, Saccharomyces cerevisiae, and Kluyveromyces marxianus. To assess the action of the postbiotic combination on diarrhoea, immune and gut epithelial cell signalling assays, the gut barrier formation assay, and the rotavirus gene expression assay were performed. ABB C22® showed a strong anti-inflammatory effect, an induction of the build-up of the gut epithelium, and a degree of protection against rotavirus infection. These experimental studies support the use of the postbiotic ABB C22® as a solution for the management of diarrhoea and gastrointestinal conditions, alone or in combination with existing but incomplete treatments. [ABSTRACT FROM AUTHOR]

Background and Aims: Cardiovascular disease and colorectal cancer (CRC) are significant health problems and share some risk factors. The aim of our study was to develop and validate a predictive score for advanced colorectal neoplasia (CRN) based on risk factors for cardiovascular disease and CRC. Materials and Methods: A cross-sectional study comprising a derivation cohort and an external validation cohort of 1049 and 308 patients, respectively. A prediction score for advanced CRN (CRNAS: Colorectal Neoplasia Advanced Score) was developed from a logistic regression model, comprising sex, age, first-degree family history for CRC, systolic and diastolic blood pressure, total cholesterol, HDL cholesterol, body mass index, diabetes, smoking, and antihypertensive treatment. Other cardiovascular risk scores (Framingham–Wilson, REGICOR, SCORE, and FRESCO) were also used to predict the risk of advanced CRN. The discriminatory capacity of each score was evaluated using the area under the curve (AUC). Results: CRN were found in 379 subjects from the derivation cohort (36%), including 228 patients (22%) with an advanced CRN. Male sex, age, diabetes, and smoking were identified as independent risk factors for advanced CRN. The newly created score (CRNAS) showed an AUC of 0.68 (95% CI: 0.64–0.73) for advanced CRN, which was better than cardiovascular risk scores (p < 0.001). In the validation cohort, the AUC of CRNAS for advanced CRN was 0.67 (95% CI: 0.57–0.76). Conclusions: The newly validated CRNAS has a better discriminatory capacity to predict advanced CRN than cardiovascular scores. It may be useful for selecting candidates for screening colonoscopy, especially in those with cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

National healthcare systems face multiple challenges, including the increasing demand for care and decreasing availability of healthcare professionals. Digital health technologies represent opportunities that offer improved efficiency, accessibility, and patient care. In this scenario, Digital Therapeutics are technological advancements to treat or alleviate a disease and deliver a medical intervention with evidence-based therapeutic impacts and regulatory approval. Digital Therapeutics are a paradigm shift for physicians, who exercise caution in terms of trust and wide usage. Digital Therapeutics represents an opportunity and a challenge in healthcare system integration. The research investigates the factors explaining physicians' acceptance of Digital Therapeutics. A research model that combines organizational mechanisms derived from Institutional Theory and rational factors derived from the Technology Acceptance model was developed. The model was tested through 107 responses from a survey distributed to the members of the leading Italian scientific society in Diabetology. Literature-based hypotheses were empirically tested through Structural Equation Modelling. The analysis confirmed the influence of Perceived Ease of Use on Perceived Usefulness and Perceived Usefulness on the Intention To Use Digital Therapeutics. Rules and norms impact Perceived Usefulness when considering the influence of the scientific society. Culture and mindset towards innovation within the hospital positively affect Perceived Ease of Use. The readiness of hospital facilities enhances the extent to which physicians perceive the ease of employing Digital Therapeutics in their daily practice. Instead, esteemed colleagues' opinions and guidelines from the scientific society reveal to physicians the value of Digital Therapeutics in patients' care pathways. Institutions should prioritize cultural, normative, and regulative aspects to accelerate physicians' endorsement of Digital Therapeutics. Findings advance the theoretical knowledge around clinicians' adoption of innovative digital health technologies, unveiling the interaction between rational and institutional factors. The results highlight practical implications for healthcare institutions and Digital Therapeutics manufacturers willing to promote their adoption. [ABSTRACT FROM AUTHOR]

Objective: Type 2 diabetes (T2D) and high blood pressure are the main causes of chronic kidney disease (CKD) in adulthood. Both metabolic and oxidative stresses driven by hyperglycemia as well as genetic factors have been suggested as pathogenic causes of renal failure. Some single nucleotide variants (SNVs) on gene coding KLOTHO (KL) have been implicated in several clinical scenarios including hypertension, diabetes, and cardiovascular disease. The aim of this study was to analyze the association of rs1207568 (–395G > A), rs953614 (+ 1062T > G) and rs564481 (+ 1818 C > T) SNVs with metabolic and renal function parameters in Mexican patients living with type 2 diabetes. Methods: A cross-sectional study was conducted in 637 Mexican patients with T2D, and/or hypertension without previous diagnosis of CKD. Anthropometric, metabolic, and renal function parameters were determined. Patients were genotyped for rs1207568, rs953614 and rs564481 SNVs and associations under a dominant genetic model were analyzed by logistic regression. Results: For rs9536314, G-allele showed to be protective for hypo-HDL-C, albuminuria, and CKD. Carriers of minor allele of rs564481 had low odds for high glucose levels. No differences in genotype nor allele frequencies between the patients and the reference population were observed. Conclusion: In Mexican patients living with type 2 diabetes, KL variant rs9536314 was found associated with low odds of hypo-HDL cholesterol, albuminuria and presence of CKD. Meanwhile the consensus of soluble KLOTHO measurement is reached, genetic variants in the KL gene could be considered as genetic markers for CKD susceptibility in patients at high-risk of vascular complications. [ABSTRACT FROM AUTHOR]

Lipid distribution in an organism is mediated by the interplay between lipoprotein particles, lipoprotein receptors and class B scavenger receptors of the CD36 family. CD36 is a multifunctional protein mediating lipid uptake, mobilization and signaling at the plasma membrane and inside of the cell. The CD36 protein family has 14 members in Drosophila melanogaster, which allows for the differentiated analysis of their functions. Here, we unravel a role for the so far uncharacterized scavenger receptor Bez in lipid export from Drosophila adipocytes. Bez shares the lipid binding residue with CD36 and is expressed at the plasma membrane of the embryonic, larval and adult fat body. Bez loss of function lowers the organismal availability of storage lipids and blocks the maturation of egg chambers in ovaries. We demonstrate that Bez interacts with the APOB homolog Lipophorin at the plasma membrane of adipocytes and trace the Bez-dependent transfer of an alkyne-labeled fatty acid from adipocytes to Lipophorin. Our study demonstrates how lipids are distributed by scavenger receptor-lipoprotein interplay and contribute to the metabolic control of development. [ABSTRACT FROM AUTHOR]