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The heterohexameric ATPases associated with diverse cellular activities (AAA)-ATPase Pex1/Pex6 is essential for the formation and maintenance of peroxisomes. Pex1/Pex6, similar to other AAA-ATPases, uses the energy from ATP hydrolysis to mechanically thread substrate proteins through its central pore, thereby unfolding them. In related AAA-ATPase motors, substrates are recruited through binding to the motor's N-terminal domains or N terminally bound cofactors. Here, we use structural and biochemical techniques to characterize the function of the N1 domain in Pex6 from budding yeast, Saccharomyces cerevisiae. We found that although Pex1/ΔN1-Pex6 is an active ATPase in vitro, it does not support Pex1/Pex6 function at the peroxisome in vivo. An X-ray crystal structure of the isolated Pex6 N1 domain shows that the Pex6 N1 domain shares the same fold as the N-terminal domains of PEX1, CDC48, and NSF, despite poor sequence conservation. Integrating this structure with a cryo-EM reconstruction of Pex1/Pex6, AlphaFold2 predictions, and biochemical assays shows that Pex6 N1 mediates binding to both the peroxisomal membrane tether Pex15 and an extended loop from the D2 ATPase domain of Pex1 that influences Pex1/Pex6 heterohexamer stability. Given the direct interactions with both Pex15 and the D2 ATPase domains, the Pex6 N1 domain is poised to coordinate binding of cofactors and substrates with Pex1/Pex6 ATPase activity. [ABSTRACT FROM AUTHOR]

It is still a desire for more local, small-scale power production that can be used to power very specific pieces of equipment or buildings. Innovation in micro-generation technologies reflects to generate heat or electricity at a small scale for individual buildings (or groups of buildings). The micro-wind sector is still at an early stage of development, but there is evidence of a growing market for the development of micro-wind systems. The performance parameters of the proposed lantern-type five-bladed micro-vertical axis wind turbine have been optimized. A novel approach of omnidirectional wind deflector with an optimized angle of attack guided the upstream wind to strike on the forward blade and thereby increase the turning speed. Furthermore, an upstream deflector produces a shield for the returning blade and diminishes the adverse effect on returning blade associated with speed of the wind turbine. Different locations and orientations of the proposed wind deflector were considered experimentally in terms of the normal displacement from the swept area of the turbine and varying the angle of the attack of the deflector to optimize the performance parameters of the turbine. A significant improvement in rotor speed, torque coefficient, and power coefficient was observed at upstream deflector angle of attack (70°–80°) when the turbine is subjected to wind velocity varying from 3.2 to 7 m/s as reported in result and discussion section. The best performance of wind turbine was observed at deflector angle of 70° at a distance of 5 cm from the tip of rotor blade. [ABSTRACT FROM AUTHOR]

In this paper, an inertial S-iteration iterative process for approximating a common fixed point of a finite family of quasi-Bregman nonexpansive mappings is introduced and studied in a reflexive Banach space. A strong convergence theorem is proved. Some applications of the theorem are presented. The results presented here improve, extend, and generalize some recent results in the literature. [ABSTRACT FROM AUTHOR]

In this work, we study an inertial extragradient-like S-iteration process for approximating a common element of the set of solutions of some variational inequality problem involving a monotone Lipschitz map and a fixed point of asymptotically nonexpansive mapping in a reflexive Banach space. The result in this paper is an extension and generalization of some recently announced results. [ABSTRACT FROM AUTHOR]

In this paper, we proposed a hybrid inertial algorithm for approximating fixed points of noncommutative generic 2-generalized Bregman nonspreading mappings with equilibrium in reflexive Banach space. Also, we proved that the sequence generated by such algorithm converges strongly to the common fixed points of such mappings and solved some equilibrium problems in the space. The result established improved and generalized some recently announced results in the literature. A numerical example is given at end of the paper to ascertain some least level of improvement. [ABSTRACT FROM AUTHOR]

In this paper, we introduce a new self-adaptive algorithm for approximating a common element of the set of solutions of generalized mixed equilibrium problems, split common null point and common fixed point of a finite family of quasi-ɸ-nonexpansive mappings in 2-uniformly smooth and uniformly convex real Banach space. Our proposed algorithm is constructed in such a way that its convergence analysis does not require a prior estimate of the operator norm. Furthermore, we establish a strong convergence result under some mild conditions. Our result improves and generalizes many existing results in the literature. [ABSTRACT FROM AUTHOR]

This paper investigates the Bregman version of the Takahashi-type generic 2-generalized nonspreading mapping which includes the generic 2-generalized Bregman nonspreading mapping as a special case. Relative to the attractive points of nonlinear mapping, the Baillon-type nonlinear mean convergence theorem for finite commutative generic 2-generalized Bregman nonspreading mappings without the convexity assumption is proved in the setting of reflexive Banach spaces. Using this result, some new and well-known nonlinear mean convergence theorems for the finite generic generalized Bregman nonspreading mapping, the 2-generalized Bregman nonspreading mapping and the normally 2-generalized hybrid mapping, among others, are established. Our results extend and generalize many corresponding ones announced in the literature. [ABSTRACT FROM AUTHOR]

In this article, porous silicon (PS)/copper oxide (CuO) film was prepared by combining electrochemical etching, pulsed laser deposition, and electrochemical deposition approaches for visible light metal-semiconductor-metal photodetector application. A series of PS/CuO photodetectors were fabricated utilizing the corresponding PS/CuO films attended with Pt contact electrodes. X-ray diffraction analysis revealed high crystallinity at a high post-processing temperature, whereas a branchy dendrite-like morphology was perceived using field emission scanning electron microscopy. Moreover, considerable photocurrent and photo-responsivity values were perceived at a high post-processing temperature. In details, the obtained photocurrent and photo-responsivity values for T-350 photodetector were 5.6 μ A and 36 m A / W , while the ideality factor and barrier height were 1.6 and 0.87 e V , respectively. The optimal photodetector (T-350) demonstrated an estimated response/recovery time of 800 m s. In addition to the consistency of the proposed device, it offers an easy pathway for optoelectronic design. [ABSTRACT FROM AUTHOR]

In this paper, we introduce a modified Halpern extragradient-type algorithm for approximating an element in the intersection of the set of common solutions of equilibrium problems and common fixed points of family of nonexpansive mappings in a complete CAT(0) space. We establish strong convergence theorem that improve and generalize recently announced results in the literature. [ABSTRACT FROM AUTHOR]

In this paper, the notion of generalized split feasibility problem (GSFP) is studied in p -uniformly convex Banach spaces. Some special cases of the GSFP are highlighted. A self-adaptive step-size iterative algorithm which converges strongly to solution of the GSFP is proved. The implementation of the method is demonstrated with two numerical examples. Our method does not require prior information of operator norms. Our results extend, improve and enrich recently announced related results in the literature. [ABSTRACT FROM AUTHOR]

In this paper, a cyclic algorithm for approximating a class of split variational inequality problem is introduced and studied in some Banach spaces. A strong convergence theorem is proved. Some applications of the theorem are presented. The results presented here improve, unify, and generalize certain recent results in the literature. [ABSTRACT FROM AUTHOR]

In this paper, a generic 2-generalized Bregman nonspreading mapping is introduced. Also, a Halpern-type iterative scheme for the approximation of attractive point of such mapping is constructed in the setting of Banach space. The result established generalized some recently announced results in the literature. [ABSTRACT FROM AUTHOR]

Let K be a nonempty closed convex subset of a real Hilbert space H1. Let be N multivalued strictly pseudocontractive mappings. In this paper, we introduce a new hybrid subgradient method for finding a common point in the set of common fixed points of a finite family of multivalued strictly pseudocontractions, the solution set of class of pseumonotone equilibrium problem and solution set of split feasibility problem. Weak and strong convergence of the iterative sequence are established. Our result is generalization and improvement of several recent results. [ABSTRACT FROM AUTHOR]

We introduce a new mixed equilibrium problem with a relaxed monotone mapping in a reflexive Banach space and prove the existence of solution of the equilibrium problem. Using Bregman distance, we introduce the concept of Bregman K-mapping for a finite family of Bregman quasiasymptotically nonexpansive mappings and show the fixed point set of the Bregman K-mapping is the set of common fixed points of {Ti}i=1N. Using the Bregman K-mapping, we introduce an iterative sequence for finding a common point in the set of a common fixed points of the finite family of Bregman quasiasymptotically nonexpansive mappings and the set of solutions of some mixed equilibrium problems. Strong convergence of the iterative sequence is proved. Our results generalise and improve many recent results in the literature. [ABSTRACT FROM AUTHOR]

We introduce an iterative process for finding common fixed point of finite family of quasi-Bregman nonexpansive mappings which is a unique solution of some equilibrium problem. [ABSTRACT FROM AUTHOR]

In this paper, using a multistep iterative scheme, we establish strong and Δ-convergence theorems for finite families of total asymptotically quasi-nonexpansive mappings in uniformly convex hyperbolic spaces. We then establish Δ- and polar convergence theorems for finite families of total asymptotically nonexpansive mappings in CAT(0) spaces. These new theorems are extensions, improvements, and generalizations of some recently announced results by many authors. [ABSTRACT FROM AUTHOR]

In this paper, using a multistep iterative scheme, we establish strong and Δ-convergence theorems for finite families of total asymptotically quasi-nonexpansive mappings in uniformly convex hyperbolic spaces. We then establish Δ- and polar convergence theorems for finite families of total asymptotically nonexpansive mappings in CAT(0) spaces. These new theorems are extensions, improvements, and generalizations of some recently announced results by many authors. [ABSTRACT FROM AUTHOR]

The article presents information on the convergence results for a common solution of a finite family of equilibrium problems and quasi-Bregman nonexpansive mappings in Banach space. It says that many problems in physics, optimization, and economics lessen to discover a solution of the equilibrium problem.

Sedghi et al. (Mat. Vesn. 64(3):258-266, 2012) introduced the notion of a S-metric as a generalized metric in 3-tuples $S:X^{3} \rightarrow[0,\infty)$, where X is a nonempty set. The aim of this paper is to introduce the concept of an n-tuple metric $A: X^{n} \rightarrow[0,\infty)$ and to study its basic topological properties. We also prove some generalized coupled common fixed point theorems for mixed weakly monotone maps in partially ordered A-metric spaces. Some examples are presented to support the results proved herein. Our results generalize and extend various results in the existing literature. [ABSTRACT FROM AUTHOR]

Colles fracture is the fracture of distal radius occurring most commonly in elderly because of the osteoprotic bone. Objectives: To compare outcome in fracture treated with Colles Plaster Case and Colles Junctional Brace. Study Design: Observational Study. Period: February 2013 to August 2013. Setting: Department of Orthopedics Bainazir Bhutto Shaheed Hospital, Rawalpindi. Methods: A study was conducted on 140 patients suffering from Colles fracture in a period of 6 months. Patients were divided in 2 groups. In group A conventional Colles cast for 6 weeks was administered and in group B Colles cast was replaced be a functional brace after 2 weeks. Functional outcome was recorded in both groups at the end of 12 weeks. Functional outcome was analyzed as given on the performa. Results: Out of 140 patients 78(55.7%) were male with a mean age of 35.87.The total number of female patients were 62(44.3%) with a mean age of 46.10 The total number of patients that had excellent functional outcome at 6 weeks were 92 out of 140 patients. The excellent functional outcome was achieved in 57(40.7%) patients treated with colles brace. However, in patients treated with colles cast the functional outcome was excellent in 35(25%) patients. Conclusions: The best functional outcome after the treatment of colles fracture is achieved by the use of colles functional brace. [ABSTRACT FROM AUTHOR]

The aim of this paper is to present common fixed point results of quasi-weak commutative mappings on a closed ball in the framework of multiplicative metric spaces. Example is presented to support the result proved herein. We also study sufficient conditions for the existence of a common solution of multiplicative boundary value problem. Our results extend and improve various recent results in the existing literature. [ABSTRACT FROM AUTHOR]

Thermoelectric generators (TEGs) have been identified as a viable technology for waste energy harvesting, from heat into electricity. Key to successful realization of this technology on a commercial scale lies largely with the thermoelectric material which drives this technology. While bismuth telluride based TEGs dominate the current market, liabilities such as toxicity, depletion of raw resources and high production costs have triggered the search for alternative thermoelectric materials. One of the contenders as thermoelectric materials in the mid-temperature range is the family of Mg-Mn silicides, given the advantages of abundance of raw resources, relatively high thermoelectric performance, lowered production costs, and environmental compatibility. In this paper, the thermoelectric performance of this class of materials is first reviewed through the key thermoelectric parameters: thermal and electrical conductivity, Seebeck coefficient and power factor. The development fabrication processes for this class of materials, using nanostructuring and element doping strategies, are then elaborated. Finally, comments on the thermoelectric applications and device efficiency are made within the context of this material. [ABSTRACT FROM AUTHOR]

Let E be a real reflexive and strictly convex Banach space with a uniformly Gâteaux differentiable norm. Let J = {T(t) : t ≥ 0} be a family of uniformly asymptotically regular generalized asymptotically nonexpansive semigroup of E, with functions u, v : [0,∞) → [0,∞). Let F := F(J) = ∩t≥0F(T(t)) ≠ ∭ and f : K → K be a weakly contractive map. For some positive real numbers Λ and δ satisfying δ + Λ > 1, let G : E → E be a δ-strongly accretive and Λ-strictly pseudocontractive map. Let {tn} be an increasing sequence in [0,∞) with limn→∞tn = ∞, and let {αn} and {βn} be sequences in (0, 1] satisfying some conditions. Strong convergence of a viscosity iterative sequence to common fixed points of the family J of uniformly asymptotically regular asymptotically nonexpansive semigroup, which also solves the variational inequality ⟨(G - βf)p, j(p - x)⟩ ≤ 0, for all x ∈ F, is proved in a framework of a real Banach space. [ABSTRACT FROM AUTHOR]

Let E be a real q-uniformly smooth Banach space whose duality map is weakly sequentially continuous. Let T : E → E be a nonexpansive mapping with F(T) 6= ;. Let A : E → E be an η-strongly accretive map which is also κ-Lipschitzian. Let f : E → E be a contraction map with coefficient 0 <α< 1. Let a sequence {yn} be defined iteratively by y0 ξ E, yn+1 = nf(yn) + (I − nμA)Tyn, n ⩾0, where { n}, and μ satisfy some appropriate conditions. Then, we prove that {yn} converges strongly to the unique solution x* ξ F(T) of the variational inequality h(f −μA)x*, j(y− x*)i ⩾ ξ, ∀ y ξ F(T). Convergence of the correspondent implicit scheme is also proved without the assumption that E has weakly sequentially continuous duality map. Our results are applicable in lp spaces, 1 < p < ∞. [ABSTRACT FROM AUTHOR]

Let E be a real Banach space satisfying local uniform Opial's condition, whose duality map is weakly sequentially continuous. Let J: = {T(t)t ≥ 0} be a uniformly asymptotically regular family of asymptotically nonexpansive semigroup of E with function k : [0,∞) →, [0,∞). L e t F := 0 ∩t≥0 F(T(t)) ≠ ∅ and f : E → E be weakly contractive map. Let G : E → E be δ- strongly accretive and λ-strictly pseudocontractive map with δ + λ > 1. Let {tn} be an increasing sequence in [0,∞) and let{αn} and {βn} be sequences in [0,1] satisfying some conditions. For some positive real number γ appropriately chosen, let {xn} be a sequence defined by x0 ∈ E, xn+1 = β nxn + (1 - β n)yn, yn = (I - αnnG) T (tn)xn + αnγf(xn), n ≥ 0. It is proved that {xn} converges strongly to a common fixed point q of the family J which is also the unique solution of the variational inequality <(G - γf)q, j(q - x)> ≥ 0, for all x ∈ F. [ABSTRACT FROM AUTHOR]

We prove a new strong convergence theorem for an element in the intersection of the set of common fixed points of a countable family of nonexpansive mappings, the set of solutions of some variational inequality problems, and the set of solutions of some equilibrium problems using a new iterative scheme. Our theorem generalizes and improves some recent results. [ABSTRACT FROM AUTHOR]

In this note we obtain and discuss formulae for the number of even permutations (of an n-element set) having exactly k fixed points. Moreover, we obtain generating functions for these numbers. We also obtain similar results for the number of odd permutations. [ABSTRACT FROM AUTHOR]

Abstract: Let be a real reflexive Banach space with a uniformly Gâteaux differentiable norm. Let be a nonempty closed convex subset of . Suppose that every nonempty closed convex bounded subset of has the fixed point property for nonexpansive mappings. Let be a family of nonexpansive self-mappings of , with . Let be a sequence in satisfying the following conditions: . For a fixed , define by where . For an arbitrary fixed , let be bounded, and let the sequence be defined iteratively by Assume that . Then, converges strongly to a common fixed point of the family . This convergence theorem is also proved for non-self maps. [Copyright &y& Elsevier]

Let E be a real q-uniformly smooth Banach space with q ≥ 1 + dq. Let K be a closed, convex and nonempty subset of E. Let [image omitted] be a family of nonexpansive self-mappings of K. For arbitrary fixed δ ∈ (0, 1) define a family of nonexpansive maps [image omitted] by Si := (1 - δ)I + δTi where I is the identity map of K. Let [image omitted] Assume either at least one of the Ti's is demicompact or E admits weakly sequentially continuous duality map. It is proven that the fixed point sequence {ztn} converges strongly to a common fixed point of the family [image omitted] where [image omitted] and {tn} is a sequence in (0, 1), satisfying appropriate conditions. As an application, it is proven that the iterative sequence {xn} defined by: x0 ∈ K, [image omitted] converges strongly to a common fixed point of the family [image omitted] where {αn} and {σi,n} are sequences in (0, 1) satisfying appropriate conditions. [ABSTRACT FROM AUTHOR]

Abstract: Let E be a real uniformly convex Banach space whose dual space satisfies the Kadec–Klee property, K be a closed convex nonempty subset of E. Let be asymptotically nonexpansive mappings of K into E with sequences (respectively) satisfying as , , and . For arbitrary , let be a sequence in , for each (respectively). Let be a sequence generated for by Let . Then, converges weakly to a common fixed point of the family . Under some appropriate condition on the family , a strong convergence theorem is also proved. [Copyright &y& Elsevier]

Abstract: Let E be a real uniformly convex Banach space, K be a closed convex nonempty subset of E which is also a nonexpansive retract with retraction P. Let be asymptotically nonexpansive mappings of K into E with sequences (respectively) satisfying as , , and . Let be a sequence in , for each (respectively). Let be a sequence generated for by Let . Strong and weak convergence of the sequence to a common fixed point of the family are proved. Furthermore, if are nonexpansive mappings and the dual of E satisfies the Kadec–Klee property, weak convergence theorem is also proved. [Copyright &y& Elsevier]

A personal narrative which explores the author's experience studying the convergece theorems for finite families of asymptotically quasi-nonexpansive mappings is presented.

Studies the photophysical properties of 4-alkyl-N-(p-cyanophenyl)piperidines in dilute and concentrated solutions and in neat melt and nematic phases by means of their static absorption and fluorescence spectra and by picosecond time-domain emission measurements. Evidence for several ground and excited-state species; Time-dependent Stokes shift.

In this paper, we prove some new common fixed point theorems for a pair of commuting G-monotone maps in a metric space with graph. Examples are also given to verify our results. The work generalize and unify a number of recently announced results in the literature. [ABSTRACT FROM AUTHOR]

In this paper, we introduce an Ishikawa-type iterative method for finding a common element of the set of fixed points of a finite family of quasi-φ-nonexpansive multi-valued mappings and the set of solutions of mixed equilibrium problems with a relaxed η - α monotone mapping in Banach spaces. Strong convergence of the iterative sequence is established. Our results improve and generalize many recent results in the literature. [ABSTRACT FROM AUTHOR]

Primer approximation multiplex PCR (PAMP) is a new experimental protocol for efficiently assaying structural variation in genomes. PAMP is particularly suited to cancer genomes where the precise breakpoints of alterations such as deletions or translocations vary between patients. The design of PCR primer sets for PAMP is challenging because a large number of primer pairs are required to detect alterations in the hundreds of kilobases range that can occur in cancer. These sets of primers must achieve high coverage of the region of interest, while avoiding primer dimers and satisfying the physico-chemical constraints of good PCR primers. We describe a natural formulation of these constraints as a combinatorial optimization problem. We show that the PAMP primer design problem is NP-hard, and design algorithms based on simulated annealing and integer programming, that provide good solutions to this problem in practice. The algorithms are applied to a test region around the known CDKN2A deletion, which show excellent results even in a 1:49 mixture of mutated:wild-type cells. We use these test results to help set design parameters for larger problems. We can achieve near-optimal designs for regions close to 1 Mb. Contact: abashir@ucsd.edu Supplementary information: Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR]

Introduction: Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes of invasive GBS disease in Qatar from all age groups.Methods: A retrospective study was conducted on patients with confirmed GBS blood stream infections during the period between January 2015 and March 2019. Microbiological identification was performed using automated BD PhoenixTM system, while additional antimicrobial susceptibility tests were performed using E test and disc diffusion methods.Result: During the four years period, the incidence steadily rose from 1.48 to 2.09 cases per 100.000 population. Out of 196 confirmed cases of invasive GBS infections, the majority were females (63.7%, 125/196) of which 44.8% were pregnant and 53.6% were colonized. Three distinct affected age groups were identified: children ≤ 4 years of age (35.7%), young adults 25-34 (20.9%) and the elderly ≥ 65 year (17.4%). Presenting symptoms were mild with fever in 53% of cases while 89% of cases had Pitt bacteraemia score of ≤ 2. Isolates were universally sensitive to penicillin, ceftriaxone, and vancomycin at 100% but with significant resistance to erythromycin (49%) and clindamycin (28.6%) while 16.8% had inducible clindamycin resistance. Clinical outcomes showed cure rate of 87.25% with complications in (8.76%) and 4% mortality.Conclusion: There is a rising trend of Group B Streptococcal blood stream infections in Qatar with significantly high clindamycin and erythromycin resistance rates. Universal susceptibility rates were demonstrated for penicillin, ceftriaxone, and vancomycin. [ABSTRACT FROM AUTHOR]

Split variational inclusion problems are core and useful technique that connects many important problems in nonlinear analysis. This paper proposes a resolvent‐based superiorization method for solving split variational inclusion problems, and some strong convergence theorems are proved under some mild conditions. Superiorization iterative procedures are simple yet powerful method that interlaces two algorithmic procedures under the assumption that one of the algorithmic procedure called the basic algorithm is resilient to the disturbances of its iterates caused by the activities of the other algorithm called perturbations. The numerical results in this paper show that our results are improvements and extensions of the corresponding results announced by many others. [ABSTRACT FROM AUTHOR]

Abstract: Let E be a q-uniformly smooth real Banach space with constant d q , q >1. Let T i : E → E, i =1,2,…, r be a finite family of nonexpansive mappings with and K = Fix(T r T r−1 … T 1)= Fix(T 1 T r … T 2)=⋯= Fix(T r−1 T r−2 … T r ). Let G : E → E be an η-strongly accretive map which is also κ-Lipschitzian. A hybrid steepest descent method introduced by Yamada and studied by various authors is proved to converge strongly to the unique solution of the variational inequality problem VI(G, K) in q-uniformly smooth real Banach space, in particular, in L p spaces 1< p <∞. [Copyright &y& Elsevier]

The article discusses a study on the approximation of fixed points of nonexpansive mappings and the solutions of variational inequalities. It states that a convergence theorem connected to finite family of nonexpansive maps is proven. It mentions that in Hilbert spaces, accretive operators are referred to as monotone where inequalities and hold with jq replaced by the identity map of H. It further states that the study aims to modify schemes and prove strong convergence theorems for the solution of the variational inequality.

Abstract: Let K be a nonempty, closed and convex subset of a real Banach space E. Let be a strictly pseudocontractive map in the sense of Browder and Petryshyn. For a fixed , define a sequence bywhere is a real sequence defined in [0,1] satisfying the following conditions (i) , (ii) . Then . If, in addition, T is demicompact, then converges strongly to some fixed point of T. [Copyright &y& Elsevier]

Paper treats access to Goal 3 of Global Goals on good health and well-being as a human right and the foundation of human prosperity. Objective is to ensure healthy lives and promote well-being for all at all ages which is essential to sustainable development. After highlighting facts & Figures and Targets by 2030 it presents an overview of Global Goal 3 that focuses on all aspects of health in the world including increased life expectancy, reduced infant mortality rates and ending epidemics such as AIDs, hepatitis and other transmittable diseases, it demonstrates that across the world over 1.3 billion people do not have access to effective and affordable health care, and 93 percent of them are in low and middle income countries including Libya. These countries only make up 18 percent of global income, and represent 11 percent of global spending on health care, meaning there's a huge imbalance. Maternal mortality rates are 14 times higher in developing countries than in developed countries, and only half of women in those regions have access to the recommended amount of health care. According to the UN, over 16,000 children under 5 die every day, mainly from malnourishment, dehydration and preventable diseases. Although significant progress has been made in improving the health of billions of people since MDGs of 2000, major hurdles remain - particularly in developing countries, where women and children are most vulnerable. True progress will depend on universal and affordable healthcare that helps prevent disease, supports strong vaccination programmes, and provides equal access to sexual and reproductive care and education. This paper on health-related research is designed to demonstrate that how threats to global health in 2018 is being tackled through preparing, preventing and responding in time.by pursuing WHO Policy of "No Regrets" to health emergencies - guided by the knowledge that outbreaks are inevitable, but epidemics are preventable. It untangles the growing social, economic, and environmental complexity that threatens to outpace the ability of governments and communities to manage the well-being of their citizens, IDPs & migrant in Libya. Because more than half of the world's population now reside in cities, we focus on urban health governance to stem the rise of non-communicable disease, respond to the emergence of global pathogens, and diminish the human health tolls of natural disasters. Our work assesses key elements of healthy development - such as Big Data ICT & infographics in health services, SMART Future HealthCare Insurance Cards at LifeCare, WHOQOL-BREF Programme On Mental Health World Health Organization, health clinics centers for Tawerghen IDPs & migrants. safe water and sanitation - to ensure that they are reinforced by health policy. Interesting results from case studies that shows it is feasible to use solar energy to power the vast hospital and research centres are presented to demonstrate that how everyone having the right to safe, effective and affordable healthcare services, medicines and vaccines can help achieve universal health coverage and progress on medical research and development. An autonomous health reform committee (NCHSR) is formed to carryout root review and reform of Libya's ailing health sector that sprang out of the Libya Health System Strengthening Programme (LHSS), set up between the Libyan authorities and the European Union to reform Libya's health sector. Finally the suggestions and recommendations to ensure that suffering belongs to no one based on four Nobel truth and eight fold path for realizing the dream of one common & interdependent planet for people health and wellbeing leading towards peace progress and prosperity are the main highlights of the paper. [ABSTRACT FROM AUTHOR]

Abstract: Developing thermoelectric materials with superior performance means tailoring interrelated thermoelectric physical parameters – electrical conductivities, Seebeck coefficients, and thermal conductivities – for a crystalline system. High electrical conductivity, low thermal conductivity, and a high Seebeck coefficient are desirable for thermoelectric materials. Therefore, knowledge of the relation between electrical conductivity and thermal conductivity is essential to improve thermoelectric properties. In general, research in recent years has focused on developing thermoelectric structures and materials of high efficiency. The importance of this parameter is universally recognized; it is an established, ubiquitous, routinely used tool for material, device, equipment and process characterization both in the thermoelectric industry and in research. In this paper, basic knowledge of thermoelectric materials and an overview of parameters that affect the figure of merit ZT are provided. The prospects for the optimization of thermoelectric materials and their applications are also discussed. [Copyright &y& Elsevier]

Motivation: Structural variants, including duplications, insertions, deletions and inversions of large blocks of DNA sequence, are an important contributor to human genome variation. Measuring structural variants in a genome sequence is typically more challenging than measuring single nucleotide changes. Current approaches for structural variant identification, including paired-end DNA sequencing/mapping and array comparative genomic hybridization (aCGH), do not identify the boundaries of variants precisely. Consequently, most reported human structural variants are poorly defined and not readily compared across different studies and measurement techniques. Results: We introduce Geometric Analysis of Structural Variants (GASV), a geometric approach for identification, classification and comparison of structural variants. This approach represents the uncertainty in measurement of a structural variant as a polygon in the plane, and identifies measurements supporting the same variant by computing intersections of polygons. We derive a computational geometry algorithm to efficiently identify all such intersections. We apply GASV to sequencing data from nine individual human genomes and several cancer genomes. We obtain better localization of the boundaries of structural variants, distinguish genetic from putative somatic structural variants in cancer genomes, and integrate aCGH and paired-end sequencing measurements of structural variants. This work presents the first general framework for comparing structural variants across multiple samples and measurement techniques, and will be useful for studies of both genetic structural variants and somatic rearrangements in cancer. Availability: http://cs.brown.edu/people/braphael/software.html Contact: braphael@brown.edu [ABSTRACT FROM AUTHOR]