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[Objective]Taking tobacco as experiment material, extraction process of tobacco polypeptide and its antioxidant activity was studied in this research. [Method]Tobacco polypeptide was extracted by enzyme-assisted water extraction and alcohol precipitation. Single factor test was used to investigate the effects of enzyme addition, enzymolysis pH, enzymolysis time, extraction temperature and substrate concentration on the extraction rate of tobacco polypeptide. The optimal extraction process of tobacco polypeptide was determined by response surface method. The scavenging activity of tobacco polypeptide on DPPH and hydroxyl radicals was detected. [Result]The optimal extraction process for tobacco polypeptide was as follows (based on 1 g tobacco sample):enzyme addition 4 200 U, enzymolysis pH 8. 2, enzymolysis time 2. 5 h, extraction temperature 49 ℃ and the substrate concentration 4. 2%. Under the optimized extraction process, the extraction rate of tobacco polypeptide was 88. 23 mg / g. The scavenging rates of DPPH and hydroxyl radicals of the tobacco polypeptide were 83. 09% and 73. 84%, respectively. Tobacco polypeptide was of a certain antioxidant capacity. [Conclusion] This study provides a certain theoretical basis and technical guidance for the medicinal value of tobacco leaves and the drug development of tobacco peptides. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of family-centered health education intervention on children with autoimmune diseases (AD). Methods A total of 120 children with AD admitted to this department from April 2020 to February 2022 were selected and divided into two groups according to the random number table method. The control group included 60 children who received routine nursing, while the observation group included 60 children who received family-centered health education on top of routine nursing. Both groups were followed up for 6 months. The treatment adherence, family health knowledge, frequency of disease onset, and family satisfaction were compared between the two groups. Results The treatment adherence score of the observation group [(5.69±1.10) points] was higher than that of the control group [(4.12±0. 86) points]. The scores of the family′s health knowledge, including causes of disease occurrence, treatment measures, and precautions for prognosis [ (80.89±7.60), (81.88±7.74), and (79.85±8.4) points, respectively], were all higher than those of the control group [(76.74±6.78), (77.71±7.22), and (76. 15±7.64) points, respectively]. The frequency of disease onset at 6 months after discharge [(3.11±0.43) times] was lower than that of the control group [(3.38±0.65) times], and the differences were statistically significant (P＜0.05). The family satisfaction rate in the observation group (95.00%) was higher than that in the control group (83.33%), and the difference was statistically significant (P＜0.05). Conclusion Family-centered health education intervention can improve the health knowledge of families and the treatment adherence of children with AD, reduce the frequency of disease onset, benefit prognosis, and achieve higher family satisfaction. [ABSTRACT FROM AUTHOR]

Submerged rigid vegetation causes uneven vertical distribution and streamwise differences of hydraulic parameters such as time- averaged flow velocity, turbulence intensity, and Reynolds stress by altering the flow structure. ADV is adopted to measure the flow velocity under three submergence ratios of 3. 0, 4. 0, and 5. 0, combined with statistical methods, the differences in velocity and turbulence characteristics within the vegetation section and its upstream and downstream transition sections are systematically analyzed. The results show that vegetation significantly enhances water flow turbulence, and the values of turbulence characteristics are positively correlated with submergence ratios. Within the vegetation segment, the differences in velocity are more significant in the two vertical zones: one is the vegetation layer under low submergence and the other is the free flow layer under high submergence. Furthermore, the values of turbulence characteristics are enhanced along the path, and the vertical distribution has similarity, with the location of maximum point is near the top of the canopy. When the submergence ratio meets the formation and development conditions of KH vortices, the turning point appears gradually in the vertical distribution curves of turbulent characteristics within the vegetation segment, near which the gradient value sharply decreases and approaches 0. In addition, the number of cross sections with turning points increases with submergence ratios increasing. It is verified that this point can serve as the upper boundary point of KH vortices in the fully developed turbulent flow region. [ABSTRACT FROM AUTHOR]

目的 通过回顾性调查2018-2021年上报的医院获得性压力性损伤 (PI) 又称院内PI不良事件现况，了解院内PI的临床特征及影响因素。方法 收集2018年1月1日至2021年12月31日在该院图特系统内上报的PI护理不良事件共208例，整理PI部位共245处。分析院内PI的时间特征、患者及当班护士的临床特征、PI发生部位及分期，单因素分析患者及当班护士临床特征因素与PI分期的相关性。结果 患者发生院内PI基本呈现逐年下降趋势，2018年以第三季度发生率最高，2019-2021年均以第四季度发生率最低。208例患者的临床特征为：男性患者发生院内PI的比例较大，患者文化程度越高与发生院内PI的比例呈现递减趋势。患者发生PI时的体位主要是被动体位和强迫体位，其中强迫体位多见于手术患者。患者的疾病类型主要是恶性肿瘤，占38.94%。当班护士临床特征：护龄分布主要集中在15年以下；发生班次以白班为主，其次是后夜班，前夜班最少。发生位置以骶尾部最高发，占46.12%。PI分期以2期为主，占58.37%。单因素分析结果显示：各因素对PI的分期分布均无显著性影响 (P＞0.05) 。结论 应更多关注男性、高龄、低学历及被动体位的患者，加强低年资护士的培训、教学与考核，以降低HAPI的发生危险。 [ABSTRACT FROM AUTHOR]

Objective To investigation the present situation of residents′ psychological reaction in post-epidemic era of 2019-novel coronavirus infection, and discuss the correlation among psychological reaction, social support and coping style, so as to provide reliable basis for the prevention and regulating of the mental health of residents in post-epidemic era. Methods Using convenient sampling method, a total of 409 residents were tested with the Psychological Questionnaires for Emergent Events of Public Health(PQEEPH), the Perceived Social Support Scale(PSSS), the Trait Coping Style Questionnaire(TCSQ). Results Fear was the main psychological reaction of residents during the public health emergency. The PSSS in residents was at mild level, which the score was(57. 89±15. 02). The score of positive coping style and negative coping style were(31. 44±8. 10) and(27. 01±7. 99), respectively. The total score of residents′ psychological reaction was positively correlated with negative coping[correlation coeffcient(r)=0. 375, P<0. 01]. The total scores of residents′ psychological reaction were negatively correlated with positive coping dimension(r=-0. 350), family support dimension(r=-0. 437), friend support dimension(r=-0. 378) and other support dimensions(r=-0. 325) (all P<0. 05). Conclusion More attention should be paid to the psychological reaction of the residents in post-epidemic era. It′s supposed to provide a scientific knowledge of epidemic prevention, health promotion for residents by grass-roots institutions such as medical staff and community, so as to improve the mental health of residents during the public health emergency. [ABSTRACT FROM AUTHOR]

Objective To evaluate the information quality of hypertension-related videos on the TikTok short video platform and assess their potential value for public health education. Methods In June 2024, we searched the TikTok short video platform using the keyword "hypertension" selecting the top 200 videos and ultimately including 177 videos for quality evaluation. Structured content integrity assessment tools and the DISCERN video quality assessment tool were used to evaluate the videos. The correlation between video quality and characteristics (duration, likes, comments, favorites, and shares) was studied. Results The 177 videos received 11 250 432 likes, 366 588 comments, 3 265 929 favorites, and 3 780 513 shares. The median video length was 111 seconds (74, 158), and the median upload days were 672 days (147, 878). 89.3% of the videos were posted by doctors, 8.5% by individual science communicators, and 2.3% by news agencies. 98.9% of the videos had subtitles, all featured individuals, and only 26.0% included animated demonstrations. Content integrity scores were: definition 0.19±0.40, symptoms 0.11±0.32, risk factors 0.29±0.50, assessment 0.36±0.45, management 0.81±0.47, and outcomes 0.63±0.58. 90.4% of the videos had a DISCERN score of ≤50, indicating "average" or below quality, with no significant difference in DISCERN scores among different publishers (P>0.05). DISCERN scores were significantly correlated with video duration (r=0.409, P<0.001). Conclusion The overall quality of hypertension-related videos on TikTok is low, with a significant positive correlation between video duration and quality. High-quality videos receive less attention, making TikTok an unsuitable platform for hypertension education due to low information quality and reliability. [ABSTRACT FROM AUTHOR]

Flavonoid-C-glycosides, as one kind of the effective components in Premna fulva, have the effect of antigen-induced arthritis. In order to optimize the enrichment and purification process of P. fulva stems, through static adsorption and desorption experiments on 13 kinds of macroporous resins with five flavonoid-C-glycosides in P. fulva stems as the index, a suitable macroporous resin was selected, and the results were tested by the HPLC, and then the orthogonal process was used to optimize the enrichment and purification conditions. The results were as follows:(1)XAD-16N macroporous resin has good adsorption and desorption effects on the five flavonoid -C-glycosides in P. fulva stems. Through single factor screening and orthogonal process optimization, the best enrichment and purification process was finally determined as that the loading concentration was two times the original extract diluted, the loading flow rate was 2 BV·h-1, and the eluent concentration was 60% ethanol.(2)The contents of five flavonoid-C-glycosides increased from 1.73%(in the original plant)to 14.50%, an increase of 7.38 times. All the results indicate that the selected extraction process is stable and feasible, and the selected macroporous resin has good separation and purification effects, which provides a reference for the drug development of P. fulva stems. [ABSTRACT FROM AUTHOR]

As the sixth largest plant hormone, brassinolide(EBR) has the effect of alleviating plant stress resistance. To investigate the alleviating effect of EBR on plant physiological characteristics under Pb stress, in this experiment, Arachis hypogaea L. was used as materials and soil pot cultivation method was applied to measure the germination and morphological indicators of Arachis hypogaea L. seeds under different mass concentrations of Pb stress. The optimal mass concentration of Pb stress was selected, and the effects of exogenous application of(0, 0.01, 0.05, 0.10, 0.50, and 1.00 mg/L) EBR at this mass concentration on Arachis hypogaea L. seed germination, seedling morphological indicators, and physiological indicators were studied. The results showed that under single Pb(NO3)2 stress, the germination potential, germination rate, embryonic root length, plant height, and root length of Arachis hypogaea L. were significantly reduced when the mass concentration was greater than 300 mg/L. Compared with the single 300 mg/L of Pb(NO3)2 stress treatment, the exogenous addition of 0.1 mg/L of EBR increased the germination potential, germination rate, embryonic root length, plant height, and root length of Arachis hypogaea L. by 28.95%, 11.76%, 27.96%, 6.18%, and 15.96%, respectively. The total chlorophyll increased by 67.34%, and the content of soluble protein and soluble sugar increased by 19.48% and 13.33%, respectively. The activity of antioxidant enzymes (SOD, POD) increased by 51.98% and 58.62%, while the content of malondialdehyde and free proline decreased by 1.67% and 20.73%, respectively. The accumulation of superoxide anion free radicals(O2·- ) decreased, indicating that exogenous EBR at 0.1mg/L had an alleviating effect on Arachis hypogaea L. seedlings under Pb stress, could reduce the damage of Pb stress to Arachis hypogaea L. seedlings and improve their stress resistance. [ABSTRACT FROM AUTHOR]

To deeply analyze the public attitude towards autonomous technology and further implement the application, an extended model of autonomous technology acceptance for different age groups was constructed by introducing the theory of planned behavior, The structural equation model was used to comprehensively reveal the influence of autonomous technology acceptance on the age difference of mechanism, Taking Chinese urban residents as example, the analysis of autonomous technology acceptance was conducted, The results show that there are differences in the acceptance of autonomous technology and the influencing factors among different age groups, In addition to subjective norms, the acceptances of groups aged from 23 to 44 and from 45 to 60 are generally higher than that of group aged from 18 to 22, especially for attitude, perceived usefulness, perceived ease of use and intention, Not all psychological variables have significant influence on behavioral intention, The behavioral intentions of groups aged from 18 to 22 and from 45 to 60 are mainly affected by the perceived ease of use, while that of group aged from 23 to 44 is affected by the perceived usefulness and perceived ease of use. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical efficacy of Dumai suspension moxibustion on patients with stroke sequelae of q1 deficiency and blood stasis and its effect on endothelial function. Methods A total of 120 patients with stroke sequelae of qi deficiency and blood stasis were selected as the research object, and randomly divided into control group and observation group, 60 cases in each group. The Pap index (BI) and stroke efficacy evaluation of the daily living ab山ty scale before and after treatment of the two groups were compared, and the improvement of symptoms and signs and vitality of the patients were evaluated. The levels of serum nitric oxide (NO) and endothelin (ET) before and after treatment in the two groups were detected. Results After treatment, the effects of BI and stroke in the observation group were better than those in the control group, and the differences were statistically significant (P<0. 05). After treatment, the ET level of both groups decreased and the NO level increased. The improvement of the observation group was better than that of the control group, and the differences were statistically significant (P<0. 05). Condosion The combination of Dumai suspension moxibustion and basic drug therapy can significantly improve the life self care ability of patients with sequelae of stroke. The curative effect is better than that of simple basic drug therapy,and it is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Objective To explore the effects of Kuntai capsule on bone mineral density, hormone levels and bone metabolism in postmenopausal osteoporosis patients. Methods 150 patients with postmenopausal osteoporosis were randomly divided into treatment group, combination treatment group and control group (n=50). The treatment group was given raloxifene and the combination treatment group was treated with raloxifene combined with Kuntai capsule for 12 months. Bone mineral density changes in hip and lumbar spine density were measured after treatment, and serum estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), The levels of osteocalcin (OC) and type I collagen cross-linked C-terminal peptide (CTX-1) were tested and adverse drug reactions occurred during treatment were recorded. Results BMD of lumbar vertebrae and hip in the control group decreased to a different extent after 1 year from baseline, and the difference was statistically significant (P<0.05). After 1 year of treatment, the hip and lumbar spine density of the treatment group and the combined treatment group were increased to different degrees, and there was significant statistical significance between the groups (P<0.05). At the same time, the serum CTX-1 level decreased and the OC level increased in the treatment group and the combination treatment group. There was significant statistical significance between the two groups (P<0.05). At the same time, the serum FSH and LH levels in each group decreased, and the E2 level increased. There was significant statistical significance between the two groups (P<0.05). No obvious adverse drug reactions were found in the two groups during treatment. Conclusion Kuntai capsule adjuvant therapy can help reduce bone turnover rate, improve sex hormone levels, and improve bone density in hip and waist in postmenopausal women with osteoporosis. [ABSTRACT FROM AUTHOR]

护理本科教育不仅要重视学生专业知识的培养, 更要注重学生包括评判性思维、临床思维能力、临床决策能力、 信息利用能力、沟通协作能力、自主学习能力等被称之为现代护理核心能力的发展。既往与内科护理学教学相关的研究论文描述 中发现, 以案例为基础的学习、以问题为中心的学习、以团队为基础的教学等教学模式存在缺乏系统性设计、流程不够优化、单次 教学耗时长、难以大范围开展教学的问题。为此, 该文拟探索一种整合合理、流程优化、方便高效, 以病例及问题分析为导向, 学生 团队自主学习为主, 教师引导为辅的以团队为基础的教学模式开展系列实践教学。提高本科护生对理论知识的理解及应用能力、 临床思维能力、临床决策能力, 提升本科护理教学质量。 [ABSTRACT FROM AUTHOR]

The product recommendation effect was affected by the trust relationship among users， the preference interest for goods and the time factor. These factors were introduced to the basic HITS algorithm， and the HITS algorithm was improved. The user preference interest matrix was also improved， which uses implicit data to estimate users′ preference for goods using logistic regression algorithm. The situation with zero score gives different preference values， which is more consistent with reality. A hybrid recommendation model was proposed by combining the improved HITS algorithm with the collaborative filtering algorithm， and users were divided into active users and inactive users for recommendation. The proposed algorithm was tested using the Movielens data set， the results showed that the algorithm could generate better recommendation result in sparse data sets and cold-start situation， and it outperforms user-based collaborative filtering algorithm. [ABSTRACT FROM AUTHOR]

Objective To explore the impact of controlling nutritional status and prognostic nutritional index on the prognosis of patients with myelodysplastic syndrome. Methods The clinical data of 119 patients with myelodysplastic syndrome treated in the department of Hematology of our hospital from March 2010 to December 2020 were retrospectively analyzed. The optimal cut-off point of observation index was calculated according to the receiver operating characteristic curve （ROC）. CONUT score and PNI were grouped based on the cut-off points of 4 and 36.75, respectively, and the differences between age, gender, blood cell count and IPSS scores were analyzed. The prognostic factors were analyzed via univariate and Cox multivariate regression analyses. Results The univariate analysis revealed that age, platelet count, bone marrow blast cell count, IPSS scores and CONUT were risk factors for the prognosis of patients with MDS. The multivariate analysis revealed that bone marrow blast cell count （HR = 1.06, 95%CI:1.01 ~ 1.12, P = 0.028） and CONUT （HR = 0.606, 95%CI:0.39 ~ 0.95, P = 0.028） were independent prognosis risk factors of patients with MDS. Conclusions High CONUT score in newly diagnosed MDS patients indicates poor prognosis and is an independent risk factor for MDS prognosis, while PNI is not an independent risk factor for MDS prognosis. [ABSTRACT FROM AUTHOR]

互联网的发展、大数据时代的到来及移动设备的普及， 使得移动学习成为热点。适时教学(JITT)模式是由美国 学者提出的一种教学模式， 作为本科教学改革项目”改革之路”的范例而受到推广。将JITT 教学模式与移动APP 相结合是一种 新颖的教学方法。作者探索了基于JITT 模式的移动APP 教学在临床教学中的应用。该教学方式以学生力主体， 促进了教师和 学生之间的交流互动， 有效提高了学生的成绩和自主学习能力，增加了学生的学习兴趣。 [ABSTRACT FROM AUTHOR]

OBJECTIVE: To evaluate the clinical efficacy and safety of Butylphthalide soft capsules in treatment of acute cerebral infarction based on Meta analysis. METHODS: KNKI, VIP database, China biomedical literature database, Pubmed, EMBase, the Cochrane Library (from Jan. 2000 to Apr. 2018) were retrieved to screen the randomized controlled trial(BCT) of Butylphthalide soft capsules in treatment of acute cerebral infarction(the control group received basic treatment, and the observation group was treated with Butylphthalide soft capsules). Literature that met the inclusion criteria were screened, and meta-analysis was conducted by using RevMan 5.2 software after Juni scoring method. RESULTS: Totally 15 literature were involved, all of which were Chinese literature. According to Meta analysis, the total effective rale(OR =2.74, 95% Cl = 1.94-3.88, P <0.05) and improvement of nerve function (MD = -2.38, 95% Cl = -2.69—2.07, P <0.05) in observation group were significantly better than those in control group, with statistically significant difference. There was no significant difference between two groups in the incidence of adverse reactions (OR =2.20, 95% Cl = 0.91-5.29, P>0.05). CONCLUSIONS: Compared with basic treatment, butylphthalide has the advantages of rapid onset of action, effective relief for clinical symptoms and high total effective rale. It is more suitable as a preferred treatment for acute cerebral infarction. [ABSTRACT FROM AUTHOR]

【Objective 】The present study was conducted to explore the effect of selenium (Se) on different triticeae crops glutathione enzyme activity. 【Method】 Under the different condition of low Se (not applied Se) and high Se (30 g/hm2 sodium selenate)， the activity of the glutathione enzyme of the second leaf of triticeae crops in tillering stage was tested， respectively. The interaction between sodium selenate and glutathione enzyme ( GSH-Px) activity was analyzed. 【Result】 The glutathione enzyme activity of the triticeae crops in the high Se environment was significantly higher than low Se environment，and different triticeae crops glutathione enzyme activities had different sensitivity for Se. 【Conclusion】 This study would provide important basis for further research of the physiological mechanism of sodium selenate intake of triticeae crops. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the drug consultation status an questions in People’s Hospital of Peking University(hereinafter referred to as "our hospital"). METHODS: A total of 21 468 cases of drug consultation records in our hospital were selected in 2017. The composition of consultants, the questions of consultation and the content of drug consultation were analyzed, and the Pareto chart was drawn. Meanwhile, the main, secondary and general factors were analyzed. RESULTS: Among the drug consultants, there were 8 907 males(41.49%) and 12 561 females(58.51%), more females than males. There were 6 702 cases(31.22%) of telephone consultation and 14 766 cases(68.78%) of on-site consultation, and on-site consultation was the main part. The main consultation questions were basic information, usage and dosage, special population medication, special dosage form and medication precautions and so on; Pareto diagram analysis results showed that basic information, usage and dosage, special dosage form,special population medication and medication precautions were the main factors, drug selection,patient education and drug interaction were the secondary factors. The content of drug consultation were mainly cardiovascular system drugs, respiratory system drugs, anti-infective drugs, central nervous system drugs and specialist drugs and so on; Pareto chart analysis results showed that cardiovascular system drugs, respiratory system drugs, anti-infective drugs, central nervous system drugs and specialist drugs were the main factors, hormones and related drugs,drugs that affect allergy and immune function were the secondary factors. CONCLUSIONS: Pharmacists provide drug counseling service for patients is helpful for the clinical rational drug use. Consulting pharmacists should strengthen the professional learning, improve the pharmaceutical service skills in a more targeted way, provide better pharmaceutical service, strengthen communication with clinicians and nurses and answer questions about medication timely, so as to promote the rational clinical drug use. [ABSTRACT FROM AUTHOR]

Objective To investigate value of preoperative magnetic resonance imaging (MRI) T2 fat suppression sequence in predicting isocitrate dehydrogenase (IDH)-1 gene expression in gliomas. Methods 124 patients with glioma, who were confirmed by histopathology, were collected. Regions of interest (ROI) was delineated using ITK-SNAP software. Pyradiomics package was used to extract radiomic features from the imaging data, while a pre-trained ResNet50 deep. learning model was employed to extract deep learning features. Feature selection was performed using the Pearson correlation coefficient and the Least Absolute Shrinkage and Selection Operator (LASSO) regression model. Model performance was evaluated through 10-fold cross-validation. Traditional radiomics, deep transfer learning, and fusion models were separately constructed based on support vector machine (SVM), k-nearest neighbors (KNN), and random forest (RF) machine learning algorithms. The predictive performance of each model was assessed using receiver operating characteristic (ROC) curve. Results The area under curve (AUC) for the machine learning models SVM, KNN, and RF based on radiomic features were 0.699, 0.628, and 0.616, respectively. For the machine learning models SVM, KNN, and RF hased on deep transfer learning features, the AUC values were 0.853, 0.753, and 0.807, respectively. The machine learning models SVM, KNN, and RF based on fusion features achieved AUC values of 0. 868, 0.818, and 0. 787, respectively. Conclusion The SVM fusion model based on the T2 WI fat suppression sequence in routine MRI exhibits higher predictive performance in determining the IDH-1 gene expression status in gliomas. [ABSTRACT FROM AUTHOR]

Objective A high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of kynurenine and tryptophan in the serum of mice, which was used to evaluate IDO activity in vivo in mice treated with IDO inhibitors. Methods Sample was precipitated with 6% perchloric acid to remove protein before centrifugation, then the clear layer was injected.Standard addition method was used for quantitative analysis. Separation was achieved by an Thermo Hypersil GOLD column (250 mm×4.6 mm, 5 μm). The mobile phase composed of 15 mmol/L sodium acetate (acetic acid adjust pH to 4.0) and acetonitrile, with a constant flow rate of 1.1 mL/min at 30 ℃. Kynurenineand tryptophan were measured at UV detection wavelength of 360 nm and 280 nm, respectively. Results The retention time of kynurenine was 6.10 min,the linear range was from 0.25 to 10 μmol/L, and the detection limit was 0.09 μmol/L. The retention time of tryptophan was 10.12 min, the linear range was from 25 to 1 000 μmol/L, and the detection limit was 0.25 μmol/L. Precision, accuracy and stability all were accorded with guiding principles for quantitative analysis of biological samples. This method was applied to determinate kynurenine and tryptophan in serum of 62 mice successfully. Conclusions The HPLC method with standard addition quantitative analysis was a simple, rapid and accurate tool for simultaneous determination of kynurenine and tryptophan in serum of mice, which was applied to biological samples successfully. [ABSTRACT FROM AUTHOR]

Aiming at the dining philosophers problem， a well-known classical example of the inter process of communication in the operating system field，this paper designs and presents a technical im­plementation scheme for a representative algorithm. The scheme takes Linux as its supporting platform，and the scheme reflects the characteristics of the concurrent behaviors of philosophers through processes rather than threads. The state of the philosophers and the switch between two states are emulated and controlled by the combination of automatic and random modes，which is a flexible and natural human-computer interaction mode. Two forms of state monitoring programs are presented，which can express the state of philosophers in a vivid，direct and accurate way. The character-based monitoring program can be used in both the character terminal and the graphic terminal，and is mainly used for those users who log in the multi-user Linux systems. The animation-based monitoring program is suitable for the desktop Linux users with graphic terminal. [ABSTRACT FROM AUTHOR]

Objective To investigate the role and possible mechanism of action of rhubarb decoction (RD) retention enema in improving inflammatory damage of brain tissue in a rat model of mild hepatic encephalopathy (MHE）. Methods A total of 60 male Sprague-Dawley rats were divided into blank group (CON group with 6 rats) and chronic liver cirrhosis modeling group with 54 rats using the complete randomization method. After 12 weeks，40 rats with successful modeling which were confirmed to meet the requirements for MHE model by the Morris water maze test were randomly divided into model group (MOD group), lactulose group (LT group), low-dose RD group (RD1 group), middle-dose RD group (RD2 group), and high-dose RD group (RD3 group), with 8 rats in each group. The rats in the CON group and the MOD group were given retention enema with 2 mL of normal saline once a day； the rats in the LT group were given retention enema with 2 mL of lactulose at a dose of 22.5% once a day； the rats in the RD1, RD2, and RD3 groups were given retention enema with 2 mL RD at a dose of 2.5，5.0, and 7.5 g/kg, respectively, once a day. After 10 days of treatment, the Morris water maze test was performed to analyze the spatial learning and memory abilities of rats. The rats were analyzed from the following aspects： behavioral status； the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-1β（IL-1β), interleukin-6（IL-6), and tumor necrosis factor-α（TNF-α) and the level of blood ammonia； pathological changes of liver tissue and brain tissue； the mRNA and protein expression levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and mammalian target of rapamycin (mTOR) in brain tissue. A one-way analysis of variance was used for comparison of continuous data between multiple groups, and the least significant difference t-test was used for further comparison between two groups. Results Compared with the MOD group, the RD1, RD2, and RD3 groups had a significantly shorter escape latency (all P<0.01), significant reductions in the levels of ALT, AST, IL-1β, IL-6, TNF- α, and blood ammonia (all P<0.05), significant alleviation of the degeneration, necrosis, and inflammation of hepatocytes and brain cells, and significant reductions in the mRNA and protein expression levels of PI3K, AKT, and mTOR in brain tissue (all P<0.05), and the RD3 group had a better treatment outcome than the RD1 and RD2 groups. Conclusion Retention enema with RD can improve cognitive function and inflammatory damage of brain tissue in MHE rats, possibly by regulating the PI3K/AKT/mTOR signaling pathway. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the reasons inducing irrational outpatient prescriptions of Peking University People's Hospital (hereinafter referred to as "our hospital"), the Pareto diagram analysis was conducted so as to provide references for clinical rational medication. METHODS:2408 outpatient prescriptions of our hospital in 2016 were collected, types of irrational prescriptions were analyzed, and Pareto diagram was adopted to analyze the principal factors, secondary factors and general factors. RESULTS: There were 8 types of irrational prescriptions in our hospital, the top 4 were respectively improper usage or dosage, inappropriate drug selection, non-indication application of antibiotics and off-label medication without any justified reasons, which were the principal factors in Pareto diagram analysis; the secondary factor was inappropriate indication medication; the general factors were improper drug combination, repeated dosing, inappropriate dosage form or administration route. CONCLUSIONS: The Pareto diagram analysis on irrational prescriptions was simple, convenient and visualized, with highlighted emphases, specific principal factors and secondary factors; the process of clinicians to prescribe need to be standardized, the establishment of hospital information system need to be reinforced, so as to give full play of pharmacist and ensure clinical rational medication . [ABSTRACT FROM AUTHOR]

目的探讨社区同伴教育在帕金森病（PD)患者中的应用效果。方法选取2014年1月至2015年1月 该科出院的110例PD患者，将其分为研究组和对照组，各55例。对照组患者接受常规健康教育，研究组患者在此基 础上接受社区同伴教育，比较两组患者不同时间段服药依从性、Barthel指数评分和PD治疗情况，并评价其应用效果。 结果两组患者出院1个月时服药依从性比较，差异无统计学意义（P>0.05);研究组患者出院3、6个月和1年时服药 依从性均高于对照组，差异均有统计学意义（P<0.05)。两组患者出院1个月时B/rthel指数评分比较，差异无统计学意义 (P>0.05);研究组患者出院3&6个月和1年时B/rthel指数评分均高于对照组，差异均有统计学意义（P<0.05)。研究组患 者出院1年时赫-雅分级情况优于对照组，差异有统计学意义（#<0.05);且研究组患者治疗有效率[96.36% (53/55)]高于对 照组[72.73%(40/55)]，差异有统计学意义（#<0.05)。结论社区同伴教育在一定程度上有利于提高社区PD患者的服药 依从性，能提高患者生活质量，可作为慢性病管理实践的重要部分。 [ABSTRACT FROM AUTHOR]

To observe the inhibitory effect of buddlejasaponin Ⅳ on tumor growth on murine transplanted hepatocarcinoma 22(H22)in vivo,tumor inhibitory activities were tested in experimental tumor H22 mice. The tumor bearing mice were randomly divided into control group,CTX group(CTX,20.0 mg/kg)and buddlejasaponin Ⅳ treatment groups(1.00,0.50,0.25 mg/kg). The body weight and survival of mice in all groups were recorded. After exposing to medications for 10 days,all the mice were killed on second day,the tumors were taken out and weighted with tumor inhibition rate,and the indexes of spleen and thymus were checked,and the SOD activity,MDA,GGT and AKP levels in serum in each group were detected. The results showed that the high and middle dosage buddlejasaponin Ⅳ treated groups could inhibit H22 growth compared with the control group(P<0.01),the inhibitory rate was 56.96%,50.63% respectively. In the high dosage buddlejasaponin Ⅳ treated groups,the activity of serum SOD increased(P<0.05),and in all the buddlejasaponin Ⅳ treated groups,serum MDA contents decreased(P<0.01). Compared with the control group,in all the buddlejasaponin Ⅳ treated groups,serum GGT,AKP content compared were highly significant differences(P<0.01),while the CTX group showed no significant difference. Buddlejasaponin Ⅳ can inhibit hepatocarcinoma growth. The mechanism may regulate the body antioxidant capacity,and needs further study. [ABSTRACT FROM AUTHOR]

The allelopathic effects of Eucalyptus grandis×E. urophlla plantation leaf volatile on surrounding crop were investigated, and seedling growth of three plants such as Zea mays, pepper, tomatoes were studied by using different quality fresh eucalyptus leaves and the eucalyptus essential oil from fresh leaves, the seed germination. The results showed that:(1)In three kinds of tested plants, E. grandis×E. urophlla leaf volatiles had little effect on zea mays seed germination, great effect on pepper;(2)When the amount was less than 200 g, E. grandis×E. urophlla leaf volatiles had no obvious effect on seed germination of three tested plants; When the dosage was 400 g, it could completely inhibit seed germination of peppers, tomatoes, and could reduce seed germination significantly(P<0.01);(3)With an increase of the dosage of leaf, the Zea mays growth first promoted and then suppressed, and it was significant(P< 0.05)or extremely significant level(P<0.01)to bud height, fresh weight, dry weight;(4)when the amount was less than or equoal to 100 g, the E. grandis×E. urophlla leaf volatiles was not obvious effect on seedling growth of peppers and tomatoes; when the amount reached 200 g, it could significantly inhibit the seedling growth peppers and tomatoes;(5)The eucalyptus essential oil had similar inhibitory effect on the 3 plants species with leaf natural volatile, and the effect was more significant. [ABSTRACT FROM AUTHOR]

Based on the Landsat remote sensing images for the landscape distribution of Suxian district of Chenzhou City in 2001,2011 and 2018, ArcGIS and Fragstats were used to analyze the changes in the landscape type structure, the landscape dynamic attitude, the landscape area transfer matrix an d the landscape pattern index in the studied a rea. Through using Clues and SP SS, the driving force factors in 17 years (17a) of this district were analyzed by the logistic regression model. The results were stated as follows: (1) In 2001-2018, the land scape type structure of Suxian district had changed dramatically, and the forest was always the major landscape type in Suxian District,occupying a ratio higher than 50%; (2) According to the land scape dynamic change in 17a,the change of construction lands was the quickest and was still accelerating, followed by the grassland s, the unused land and the cultivated land; (3) In terms of land scape type, the landscape shape index of the forest, the grassland, the cultivated land and the construction land increased, which means that the boundary complexity was increased due to the affection of human activities ; (4) In terms of landscape level, the land scape structure of Suxian district maintained a good diversity, the area ratio of each sector was coming closer to balance, and the landscape fragmentation degree was increasing; ( 5) According to transition matrix of landscape area, within the red-line for basic farmland protection, lots of agricultural lands had been converted into construction lands; the continuous expansion of construction lands would gradually become the major landscape of this district; (6) According to driving force factor analysis, natural factors gave more impact on forest, grasslands, cultivated lands and water area; social and economic factors gave more impact on construction lands and unused lands. This research has directive significance to urban landscape ecological planning and future construction of Suxian District, and it also provides important reference for urbanization development and urban landscape planning in China. [ABSTRACT FROM AUTHOR]

Objective To investigate related influencing factors in patients with type 2 diabetes mellitus（T2DM） and nonalcoholic fatty liver disease（NAFLD）. Methods A total of 252 patients with T2DM who were treated in Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine from May 2021 to March 2022 were enrolled as subjects, and these patients were also included in Metabolic Management Center of China. According to the presence or absence of fatty liver disease, the patients were divided into simple T2DM group（n=105） and T2DM+NAFLD group（n=147）. Related general data were analyzed, including sex, age, blood pressure, body height, body weight, neck circumference, triglyceride（TG）, total cholesterol, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol, fasting blood glucose, glycosylated hemoglobin, high-sensitivity C-reactive protein, albumin/creatinine ratio in morning urine, thyroid stimulating hormone, uric acid, intrahepatic fat deposition, carotid intima-media thickness, and brachial-ankle pulse wave velocity. The group t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between groups. A multivariate logistic regression analysis was used to investigate the risk factors for T2DM with NAFLD, and the receiver operating characteristic（ROC） curve was used to assess the predictive value of related influencing factors. Results The age-stratified analysis showed that in the ＜50 years age group, compared with the patients with T2DM alone, the patients with T2DM and NAFLD had significantly higher levels of body mass index（BMI）, visceral fat, TG, brachial-ankle pulse wave velocity, albumin/creatinine ratio in morning urine, and uric acid（P＜0.05）; in the ≥50 years age group, compared with the patients with T2DM alone, the patients with T2DM and NAFLD had significantly higher levels of blood pressure, BMI, visceral fat, TG, brachial-ankle pulse wave velocity, albumin/creatinine ratio in morning urine, and uric acid（P＜0.05） and a significantly lower level of serum HDL-C（P＜0.05）. The multivariate logistic regression analysis showed that BMI（odds ratio [OR]=1.408, 95% confidence interval [CI]: 1.136-1.746, P=0.002）, HDL-C（OR=0.031, 95% CI: 0.001-0.647, P=0.025）, left brachial-ankle pulse wave velocity（OR=1.003, 95% CI: 1.001-1.006, P=0.003）, and uric acid（OR=1.011, 95% CI: 1.005-1.016, P＜0.001） were independent influencing factors for T2DM with NAFLD. The ROC curve analysis showed that HDL-C, BMI, left brachial-ankle pulse wave velocity, and uric acid had an area under the ROC curve of 0.695（95% CI: 0.574-0.812）, 0.708（95% CI: 0.628-0.788）, 0.611（95% CI: 0.523-0.698）, and 0.698（95% CI: 0.617-0.779）, respectively, in evaluating T2DM with NAFLD. Conclusion Low levels of HDL-C, BMI, left brachial-ankle pulse wave velocity, and uric acid have a certain value in predicting NAFLD in patients with T2DM. [ABSTRACT FROM AUTHOR]

For the acceptance of autonomous vehicles technology, the mapping knowledge domain was applied to analyze and visualize the relationship between the research and development process and the knowledge network in the field of the acceptance of autonomous vehicles technology based on the annual trend of published literature, national cooperation network, publications and periodicals, acceptance behavior theory, influencing factors and data analysis methods. The results show that the United States, Germany and China are the major contributors to the field. The safety of autonomous vehicles technology is the primary affecting factor on public acceptance, and trust, attitude, perceived ease of use, perceived usefulness, perceived risk and social norms are the most important psychological influencing factors on the acceptance. Descriptive statistics and analysis of variance, regression analysis, factor analysis, structural equation model, Logit model and Probit model are the main research methods in the field. However, the existing theoretical models of acceptance of autonomous vehicles technology have low explanatory power, and the symbolic value and key psychological influencing factors on the acceptance of autonomous vehicles technology with Chinese characteristics should be further explored. The samples with deviation and the adding autonomous vehicles technology simulator should be further analyzed. [ABSTRACT FROM AUTHOR]

Objective To systematically evaluate the correlation between Helicobacter pylori (HP) infection and psoriasis. Methods Case-control studies related to HP infection and psoriasis were collected by searching China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, Web of Science, EMBase, Cochrane Library and other Chinese and English databases. The retrieval period was from the establishment of the database to December 2021. Two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies, and then performed a meta-analysis using Stata14.0. Results A total of twelve studies were included, with a total of 1, 818 subjects participating. Meta-analysis showed that the infection rate of HP in psoriasis group was significantly different from that in healthy population [odds ratio (OR) =2.12, 95 % confidence interval (95%CI) (1.42-3.76), P <0.05]. Subgroup analysis showed that the incidence of HP infection in Asian psoriasis patients was higher than that in healthy people, and the difference was statistically significant (P <0.05), while the incidence of HP infection in non-Asian groups was not statistically significant (P>0.05) . HP infection was determined by urea breath test and serological method. The HP infection rate in psoriasis group was significantly higher than that in healthy people, and the difference was statistically significant (P<0.05) . However, there was no significant difference in the diagnosis of HP infection by fecal antigen method (P>0.05) . The skin lesion area and severity index (PASI) of moderate and severe psoriasis in patients with HP infection were significantly higher than those without HP infection (P<0.05), while there was no significant difference between mild PASI and psoriasis patients without HP infection (P>0.05) . Conclusion The infection rate of HP in patients with psoriasis is higher than that in normal subjects, and it is affected by different regions and detection methods. In addition, HP infection may affect the severity of patients with psoriasis. [ABSTRACT FROM AUTHOR]

Objective To investigate the correlation between serum C-peptide and carotid atherosclerosis(CAS)in patients with type 2 diabetes. Methods A total of 182 patients with type 2 diabetes admitted to the hospital in January and December 2017 were divided into CAS group(n=129)and no CAS(NCAS group, n=53). The body mass index(BMI), glycated hemoglobin, triglyceride, total cholesterol, fasting and 2-hour post-meal blood glucose, fasting and 2-hour post-meal C-peptide in the two groups were compared and analyzed. Carotid IMT was taken as dependent variable, fasting and 2-hour post-meal C-peptide, BMI were taken as independent variables to be analyzed by multiple linear regression model. Results The BMI, glycated hemoglobin, total cholesterol and 2-hour post-meal blood glucose in CAS group were significantly higher than those in NCAS group, while fasting and 2-hour post-meal C-peptide levels were significantly lower than those in NCAS group, the differences were statistically significant(P<0.05). Multivariate linear regression analysis revealed that carotid IMT was positively correlated with glycosylated hemoglobin and total cholesterol(P<0.05), but negatively correlated with fasting and 2-hour post-meal C-peptide(P<0.05). Conclusion The CAS level of diabetic patients is closely related to the decrease of C-peptide level. [ABSTRACT FROM AUTHOR]

Tapping-enhanced rubber biosynthesis is closely related to the activation of jasmonate signaling in laticifer cells of rubber tree. The relationship between the expression level of the genes involved in jasmonate signaling and dry rubber yield remains not elucidated. In the present study, the expression of nine genes related to jasmonate signaling was analyzed by qPCR in the laticifer cells of five Wichham germplasms and 5 1981'IRRDB germplasms upon tapping with S/2 d/3 tapping system. The rubber yield per tapping of most Wichham germplasms was significantly higher than that of 1981'IRRDB germplasms. Except for HbMYC4 and HbMYC5, the expression level of the other seven genes in most of Wichham germplasms was significantly higher than that of 1981'IRRDB germplasms. It was noted that the expression of HbMYC3 was highly different and closely related to the rubber yield, which may be used as a candidate marker for rubber yield-breeding of rubber tree. [ABSTRACT FROM AUTHOR]

With the privacy issues drawing more and more concerns, privacy protection techniques based on Computational Private Information Retrieval (CPIR) allow a user to retrieve data from a service provider without revealing the users query information. For large-scale applications, there exists a gap between privacy protection techniques and its feasibility. For the problem that the CPIR algorithm needs long computing time so as not to be suitable for large-scale data privacy protection, this paper proposes a CPIR nearest neighbor privacy protection algorithm (H-PCPIR-V) based on Spark and Huffman code. The H-PCPIR-V algorithm partitions the spatial data into Voronoi diagrams according to the points of interest in the data preprocessing stage, and then utilizes the Huffman code to compress the candidate data in order to reduce bit computation operation. Spark parallel framework is used for query grid parallel computing in the server side. The experimental results show that the computational cost of H- PCPIR V algorithm is about 30M lower than that of PCPIR-V algorithm on the server side, the computational cost of client is about 10% lower, and the communication cost is about 40% lower. [ABSTRACT FROM AUTHOR]

To study the effects of L-arabinose on modulating levels of uric acid in hyperuricemia and normal mice. L-arabinose were administrated to hyperuricemia mice and normal mice. Mice models with hyperuricemia were induced with oxonic acid potassium salt and hypoxanthine or with oxonic acid potassium salt and uric. We determinated levels of urate excreted. We also measured levels of uric acid, total cholesterol, triglyceride, glucose, creatinine, urea nitrogen in serum, xanthine oxidase activity in liver and small intestine, liver index, kindey index and spleen index. The results showed that L-arabinose could promote uric acid excretion, but had no effect on serum levels of uric acid in normal mice; could promote serum levels of uric acid, but had no effect on uric acid excretion in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine; had no effect on uric acid excretion and serum levels of uric acid in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine uric. This indicates that L-arabinose has no effect on normal serum levels of uric acid; but can promote serum levels of uric acid in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine. [ABSTRACT FROM AUTHOR]

BACKGROUND: There are few studies on myeloid-derived growth factor (MYDGF) and atherosclerosis and metabolic diseases. Therefore, a mouse model of bone marrow specific MYDGF deficiency with apolipoprotein E (ApoE) knockout is particularly important for studying the relationship between MYDGF and atherosclerotic diseases. OBJECTIVE: To establish and identify the mouse model of bone marrow specific MYDGF deficiency with ApoE knockout. METHODS: ApoEflox/flox mice and bone marrow specific MYDGFflox/flox mice were purchased from the Shanghai Model Organisms Centre, Inc (Shanghai, China). Five ApoEflox/flox male mice were selected to mate with 10 MYDGFflox/fiox female mice, and 30 F1 progeny mice with genotype of MYDGFflox/+ApoEflox/+ were obtained and mated with each other. Finally 30 mice with genotypes of MYDGFflox/floxApoEflox/flox and 34 ApoEflox/flox progenies were obtained. The MYDGFflox and ApoEflox genotypes were identified by PCR, and the body length and body mass of MYDGFflox/floxApoEflox/flox mice and ApoEflox/flox mice at 2 months were recorded. The expression of MYDGF protein in the mouse bone marrow tissues was detected by western blot assay, and immunofluorescence was used to detect the expression of MYDGF in the mouse bone marrow cells. The plaque area of the thoracic aorta in the mouse was detected by oil red O staining. The study was approved by the Animal Ethic Committee of PLA General Hospital of Central Theater Command. RESULTS AND CONCLUSION: There were 34 ApoEflox/flox mice and 30 MYDGFflox/floxApoEflox/flox mice, with no significant difference in their body length and body mass (both P > 0.05). The relative expression level of MYDGF protein in the bone marrow of MYDGFflox/floxApoEflox/flox mice was significantly lower than that of ApoEflox/flox mice (P < 0.05). The percentage of plaque area in the thoracic aorta of MYDGFflox/floxApoEflox/flox mice was significantly higher than that of ApoEflox/flox mice (P < 0.05). Therefore, MYDGF gene was successfully knocked out in ApoEflox/flox mice, and the homozygous mouse model of bone marrow knockout MYDGF gene in ApoE knockout mice was successfully constructed and identified by genotype and protein tissue levels. To conclude, MYDGF gene deficiency can aggravate atherosclerosis in ApoE knockout mice. [ABSTRACT FROM AUTHOR]

HUT model (Helsinki university of technology snow emission model) is a semi-empirical radiative transfer model of passive microwave remote sensing of snow- and it considered the impact of soil, forests and atmosphere on brightness temperature receiving by the sensor. HUT model was able to simulate brightness temperature receiving by the sensor. This paper validated HUT model based on MWR1 data mounted on FY-3B satellite. The results showed that there was a big difference between brightness temperature of HUT' model simulation and brightness temperature of MWRI for 18.7 GHz horizontal polarization and 36.5 GHz horizontal polarization. So this paper improved the extinction coefficient formula. The model that used the improved extinction coefficient formula calculating extinction coefficient was called improved HUT model (IMI'HUT model'. The validation result of IMI'HUT model indicated that: the bias of IMI'HUT model for 18.7 GHz horizontal polarization and 36.5 GHz horizontal polarization were -0.91 K and -4.19 K respectively. However the bias of HUT model for 18.7 GHz horizontal polarization and 36. 5 GHz horizontal polarization were 14.03 K and -16.33 K respectively. Simulation accuracy of IMPHUT model was greatly improved. Finally, genetic algorithm was used to inverse snow depth on January 20. 2013. The result showed that bias of inversion snow depth based on IMPHUT model was -6.79 cm. The inversion snow depth based on IMPHUT model which was superior to HUT model and Chang algorithm was in good agreement with the measured snow depth. [ABSTRACT FROM AUTHOR]

Background and purpose: The International Federation of Gynecology and Obstetrics (FIGO) 2018 revised the staging system for cervical cancer with new stage ⅢC. However, patients with stage ⅢC exhibit heterogeneous clinical characteristics, and the prognosis is different. This study aimed to investigate the prognostic value of 2018 FIGO new stage system for cervical cancer patients in stage ⅢC. Methods: A case-control study was conducted to collect the clinical data of patients with stage Ⅲ cervical cancer treated in Gynecological Oncology Center, Chongqing University Cancer Hospital from January 2011 to December 2014 according to the inclusion and exclusion criteria. The survival status and prognostic factors were analyzed retrospectively. Kaplan-Meier method was used to calculate the survival rate. Log-rank test was used for univariate survival analysis, and Cox proportional hazards regression model was used for multivariate survival analysis. Results: A total of 418 cases were included in the study, in which stage ⅢA had 42 cases (10.0%), stage ⅢB had 120 cases (28.7%), stage ⅢC1 had 190 cases (45.5%) and stage ⅢC2 had 66 cases (15.8%). There was significant difference in age among the four groups (P=0.003). There was no significant difference in histological type, histological differentiation, tumor size, radiotherapy type and consolidation chemotherapy (P>0.05). Survival analysis showed that the 5-year overall survival (OS) rate of stage ⅢC1 disease was 54.1%, higher but not statistically significant compared with stage ⅢB (40.6%, P=0.042) and ⅢA (43.3%, P=0.484). The stage ⅢC2 had a significantly worse OS compared with stage ⅢC1, ⅢA and ⅢB (P<0.01), and 5-year OS rate was 23.1% for ⅢC2. Multivariate analysis showed that the stage ⅢC1 disease did not increase the risk of death compared with stage ⅢA (HR=1.432, 95% CI: 0.867-2.366, P=0.161) and ⅢB (HR=1.261, 95% CI: 0.871-1.827, P=0.219). The risk of death was nearly 3 times higher in ⅢC2 than in ⅢA (HR=2.958, 95% CI: 1.757-4.983, P<0.001). The survival of stage ⅢC1 disease differed significantly based on T stage (P<0.001). Multivariable analysis showed T stage remained an independent prognostic factor for survival in patients with stage ⅢC1 disease, and 5-year OS rate was 72.2% for T1, 54.1% for T2 and 18.6% for T3 (P<0.001). The 5-year OS rate of stage ⅢC1 (T1) patients was 72.2% with better 5-year OS compared with stage ⅢA (P=0.004) and ⅢB (P<0.001). Based on the pathological stage and imaging stage, the 5-year OS rate of stage ⅢC1p (T1/T2a) was 64.5%, which was significantly higher compared with stage ⅢC1r (T2b/T3) (34.9%, P<0.001). The prognosis of patients with stage ⅢC1p (T1/T2a) was significantly better than that of patients with stage ⅢB (P<0.001). Conclusion: The prognosis of patients with stage ⅢC2 disease has distinct characteristics. However, the stage ⅢC1 is heterogeneous, and its prognostic evaluation should be combined with T stage. [ABSTRACT FROM AUTHOR]

[摘 要] 目的 通过运用行为阶段模型(TTM)对医学生临床技能学课程学习动机进行评估,探索虚拟仿真教学方法的积 极作用。方法 选取该校处于本科第3学年2学期临床医学专业学生240名,在均衡原则下随机分配入虚拟仿真教学组及传统 教学组,每组120名。进入分组前和学期末,学生完善 TTM 评估量表;同时搜集学期末临床技能诊断部分的实践考核成绩进行 统计学分析。结果 学期末,虚拟仿真教学组学习动机处于第四、五阶段学习阶段学生所占比例优于传统教学组,差异有统计学 意义(P<0.05)。虚拟仿真教学组平均成绩[(80.13±3.32)分]高于传统教学组[(74.26±4.25)分],差异有统计学意义(t= 6.42,P<0.05)。结论 TTM 直观显示了虚拟仿真教学方法在提升医学生学习动机方面的优势,值得在教学评价实践中推广. [ABSTRACT FROM AUTHOR]

Objective This paper discussesed the use of O2O lifestyle in college students， the characteristics of health-related behaviors of college students under the influence of this new style and their influencing factors. Methods A questionnaire survey of 840 medical college students was conducted by stratified cluster sampling. Results It was found that 95.10% of the college students used O2O. The health-related behavior report showed that the college students generally had good dietary and nutritional behavior， but there were some health-risk behaviors， such as long online time，irregular work and rest，and so on. There was a certain correlation between the use of O2O in college students and health-promoted， especially the use time of O2O was negatively correlated with the behavior of health-promoting exercise. The results of logistic regression also suggested that college students who used O2O for less than one year had better health-promoting sports behavior. Conclusion The use of O2O was common among college students，which was influenced by many factors， and had some correlations with health-related behaviors. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical efficacy and safety of mecobalamin combined with traditional Chinese medicine(TCM) plus Huangqi Guizhi W u w u decoction and acupuncture in treatment of diabetic peripheral neuropathy (D P N) with qrdeficiency-blood-stasis syndrome. Methods: 120 D P N patients with qi~deficiency-biood~stasis syndrome admitted to Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to September 2017 were randomly divided into the control group, the T C M treatment group, the acupuncture treatment group and the comprehensive treatment group, each consisting of 30 patients. The patients in the control group were treated with conventional neurotrophic therapy (mecobaiamin 500 jJ-g, tid), the patients in the T C M treatment group were treated with plus Huangqi Guizhi W u w u decoction on the basis of the treatment received by the control group, the patients in the acupuncture treatment group were treated with acupuncture on the basis of the treatment received by the control group, and the patients in the comprehensive treatment group were treated with plus Huangqi Guizhi W u w u decoction and acupuncture in addition to the treatment received by the control group. The clinical efficacy, Toronto Clinical Scoring System (TCSS) scores, TCM syndrome scores, anxiety scale scores and adverse drug reactions were compared before and after treatment among the 4 groups. Results: The total effective rates of the T C M treatment group, the acupuncture treatment group and the comprehensive treatment group were all significantly higher than that of the control group (P=C0.05), and the T C M syndrome scores of the T C M treatment group, the acupuncture treatment group and the comprehensive treatment group after treatment were dramatically better than that of the control group (P=C 0.05). The T C S S scores and anxiety scores of the 4 groups were significantly decreased(P=O. 05) after treatment, and the decreased level of the T C M treatment group, the acupuncture treatment group and the comprehensive treatment group was significantly better than that of the control group (P=CO. 05). Conclusion: The combination of traditional Chinese and western medicine for the treatment of D P N with qi "deficiency-blood-stasis syndrome could achieve obvious therapeutic efficacy, alleviate clinical symptoms and anxiety, improve T C M symptom scores, and enhance overall treatment efficiency. [ABSTRACT FROM AUTHOR]

目的通过运用行为阶段模型（TTM）对不同层次本科医学生临床课程学习动机进行分析，揭示不同层次本科医学生在学习动机方面的区别并探讨学习动机对学习效果的影响。方法随机从南华大学衡阳医学院和湖南医药学院各筛选60名学生，根据学生实际情况，制定针对学习动机分析的TTM评估量表。在接受临床课程学习半学期后，请学生完善调查量表；再搜集临床课程的期末理论及迷你临床演练评估（Mini-CEX）测试成绩进行统计学分析。结果2所高校医学生临床课程学习动机行为阶段分布比较，差异有统计学意义（P<0.05）,且学习动机所处行为阶段对学习效果有一定影响，尤其是MiniCEX成绩。结论根据实际情况制定的TTM可全面细致地分析和评估医学生学习动机，值得在以后的教学工作中不断改进和推广。 [ABSTRACT FROM AUTHOR]

In order to improve the undesirable flow pattern such as flow deviation, reverse current, vortex caused by the bend flow in the forebay of pumping station, based on the Fluent software, the RNG k-ε turbulent was used to close the Navier-Stockes equations，the SIMPLEC algorithm method was used to simulate the flow field of side-inlet pumping station. The velocities and streamlines about the original and the rectifying schemes had been compared, the uniformity of normal velocity as target function had been adopted to analyze the inlet condition of forebay of pumping station. The results show that the flow pattern is significantly improved when the combined type diversion pier is arranged in the forebay and the length of guide wall is extended, making it earlier for flow to change direction. And there is no flow deviation and reverse current in the forebay. The rectifying measures can increase the straightness and uniformity of flow to make pumping station run effectively. [ABSTRACT FROM AUTHOR]

BACKGROUND: Elite skaters at international level have been shown to hold more rational muscle strength characteristics of joints than the elite skaters at national level. Force indexes are reported to be related to grade, suggesting that the muscle strength characteristics of lower limb joints of skaters are closely related to professional competitive ability. OBJECTIVE: To study the characteristics of isokinetic muscle strength of lower limb joints in elite female short track speed skaters, so as to provide references for strength training and provide data for revealing sports characteristics. METHODS: Centripetal isokinetic testing was performed in hip, knee and ankle joints of elite female short trakck speed skaters (numbered as 1, 2, 3 and 4) at international level using Isomed 2000. All skaters underwent thrice subultimate strength adaptive staining before testing, and 2 minutes later, the isokinetic testing was conducted. The angular velocity was set as 60 (°)/s (low velocity) and 180 (°)/s (high velocity), respectively based on preliminary results. The low velocity repeated 5 times and high velocity repeated 7 times, 5 minutes in between. Flexion/extension was a cycle, and the highest values were selected for analysis. RESULTS AND CONCLUSION: In the high and low velocity speed, all data in ankle and knee had good corresponding relationship, but not hip. Peak torques of ankle and knee joints were on a descent with velocity increasing, and average power increased with velocity increasing. Velocity had impaction on muscle ratio in ankle and knee joints but not hip. Velocity had little impaction on peak torque angle. The flexor and extensor of No.1 skater performed well. The balance between right and left legs of No.1 skater needed to be improved. The ankle strength in No. 3 skater performed well, but the strength of knee and hip needed to be improved. The knee strength of No. 4 performed well, but the speed strength of ankle and hip extensors needed to be improved. In summary, the strength of ankle and knee flexors and extensor in Chinese elite athletes get a well development, but not hip. The elite athletes have higher peak torque, muscle strength ratio shows special features, the balance between right and left knee peak torque, and the peak torque angle is stable, which meet the special requirements. Knee muscle strength in four elite skaters reflects the common characteristics. The hip muscle strength should be improved. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of α-Synuclein on the spatial learning and memory of mice. Methods: The transgenic mice over-expressed α-Syn were used as models to observe the swimming path and the time to complete the task in the Morris water maze which included the navigation test, spatial probe test and visual platform experiment. Results:In the navigation test, the time to search for the two groups of mice was shortened with the training time prolonged. Compared with the wild type mice, the escaped latency oftransgenic mice over-expressed α-Syn was prolonged in the navigation test (58.77±1.32 versus 17.34± 6.44, *P＜0.05) and the target quadrant shortened(17.91± 2.14 versus 5.59± 4.98, *P＜0.05). Meanwhile, in order to further prove that the spatial memory and learning ability of Tg-α-Syn mice are related to hippocampus. There was no significant difference between the two groups of mice in the search latency of visual platform experiments (P＞0.05). Conclusion:The over-expression of α-Syn could impaire the spatial memory and learning depended hippocampus. [ABSTRACT FROM AUTHOR]

In order to determine the yeast quality for making frozen dough and steamed bread better and more stable, we studied the changes of characteristics of fermentation and rheology of frozen dough made by Guoguang low-sugar high-activity dry yeast (No.1), Actis Mali Apple instant high-active dry yeast (No.2), Pinyi high-activity dry yeast (No.3), Mali high-sugar instant high-active dry yeast (No.4), Danbaoli high-sugar instant high-active dry yeast (No.5) and Angel high-sugar-intolerance high-activity dry yeast (No.6) The doughs which were frozen and stored for 35 days, were analyzed by dynamic rheometer and Rheofermentometer F3, and the texture, color, specific volume and sensory quality of steamed bread made by frozen dough were compared. The results showed that frozen doughs made from different commercial yeasts in different frozen time had different rheological properties and fermentation characteristics. After making steamed bread, their hardness, springiness, resilience, chewiness, lightness, redness, yellowness, specific volume and scores of sensory evaluation showed significant difference (P<0.05) among different yeasts. Their texture, color, specific volume and sensory quality were also significantly different (P<0.05) among different frozen time for the steamed bread made by the same yeast. Frozen doughs made by No. 1 and No.2 always maintained higher fermentation activity, No. 6 had the most stable fermentation characteristics parameters of six kinds of yeasts during the frozen storage of 35 days. Then frozen dough made by No.1, No.5 and No.6 had higher elastic modulus and viscous modulus, No.5 had the most stable rheological properties. The steamed bread made by the frozen dough of No.1 and No.6 always had better sensory quality larger specific volume, better color, and better texture quality. Therefore the frozen dough and steamed bread made by No.1 had better quality and stability, followed by No.6. The results provide a theoretical basis for the selection of yeast in the industrial production of steamed bread made by frozen dough. [ABSTRACT FROM AUTHOR]

Based on the statistical analysis of roof tunnel gas extraction used in China，in order to coordinate the relationship between roof tunnel gas extraction and coal spontaneous combustion，and to solve the problem of the coal spontaneous combustion induced by roof tunnel gas extraction，a case study was conducted in the Gengcun Mine，China. Firstly，though analyzing the measured data of roof tunnel gas composition and gob temperature，the occurrence of air leakage and coal spontaneous combustion were confirmed；Secondly，the air leakage passage and the constitute of air leakage power were identified by numerical calculation and theoretical analysis，and the mechanism of inducing coal spontaneous combustion under roof tunnel gas extraction was revealed；Thirdly，the concept of safe gas extraction volume was presented. According to the conservation of mass，using the ventilation air methane and the width of oxidized zone as constraint indices，the mathematical model of safe gas extraction volume was established. Through the model was tested，the mathematical model was verified and shown its validity and effectiveness. [ABSTRACT FROM AUTHOR]

In order to evaluate the stability of mogroside V in gastrointestinal tract and study its in vitro metabolism, mogroside V was incubated with artificial gastric juice and human intestinal bacteria, and a liquid chromatography/mass spectrometry method by LCMS/IT-TOF was applied to analyze the products of mogroside V in artificial gastric juice and human intestinal bacteria culture medium. The results indicated that mogroside V was degraded quickly in artificial gastric juice to be secondary glycosides with two glycosyls or one glycosyl and mogrol without glycosyl. And the longer time it was incubated, the more completely it was degraded, its product was mogrol while the incubation time was 4 h. While in culture medium of human intestinal bacteria, mogroside V was transformed to mogroside IV(isomer)mogroside III(isomer), mogroside II(isomer)and mogroside I(isomer)by deglycosylation reaction, as well as to glycoside with six glycosyls,by glucosylation reaction. Therefore, a general knowledge on the degradation of mogroside V was obtained after this experiment, which would shed light on the further exploitation of mogroside V and Siraitia grosvenorii. [ABSTRACT FROM AUTHOR]

目的探讨尿液中前列腺癌基因3(PCA3)评分在血清总前列腺特异抗原(t PSA)灰区(4~10 ng/m L)的前列腺癌患者早期诊断中的应用价值。方法 t PSA灰区患者103例,其中前列腺癌患者29例(前列腺癌组)、前列腺良性增生(BPH)患者74例(BPH组)。采用荧光定量PCR法检测患者尿液中PCA3基因表达,计算尿PCA3评分,并绘制ROC曲线分析尿液PCA3评分对前列腺癌早期诊断的价值。结果前列腺癌组与BPH组比较,尿PCA3评分高,前列腺体积小(P均0.05)。尿PCA3评分的ROC曲线下面积高于血清t PSA(P0.05),取截断值71.5,尿PCA3评分诊断前列腺癌的敏感度及特异度分别为82.8%及81.1%。结论尿PCA3评分可提高血清t PSA灰区前列腺癌患者诊断的准确度。 [ABSTRACT FROM AUTHOR]