α-突触核蛋白对小鼠空间学习记忆能力的影响.

Objective: To investigate the effect of α-Synuclein on the spatial learning and memory of mice. Methods: The transgenic mice over-expressed α-Syn were used as models to observe the swimming path and the time to complete the task in the Morris water maze which included the navigation test, spatial probe test and visual platform experiment. Results:In the navigation test, the time to search for the two groups of mice was shortened with the training time prolonged. Compared with the wild type mice, the escaped latency oftransgenic mice over-expressed α-Syn was prolonged in the navigation test (58.77±1.32 versus 17.34± 6.44, *P＜0.05) and the target quadrant shortened(17.91± 2.14 versus 5.59± 4.98, *P＜0.05). Meanwhile, in order to further prove that the spatial memory and learning ability of Tg-α-Syn mice are related to hippocampus. There was no significant difference between the two groups of mice in the search latency of visual platform experiments (P＞0.05). Conclusion:The over-expression of α-Syn could impaire the spatial memory and learning depended hippocampus. [ABSTRACT FROM AUTHOR]