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In order to evaluate the relationship between human and water quantitatively, taking Xi'an City as an example, the evaluation index system of human and water harmony was built on the basis of the concept of human and water harmony. The weights of each index were calculated by improving G1 weighting method. Based on the comprehensive development level of water system and human system, the coupling coordination model was used to calculate the coordination degree of human water system, and the obstacle factors were identified by the obstacle degree model. The evaluation method of single index quantification, multi-index synthesis and multi-criteria integration was adopted to calculate the health degree of effluent system and the development degree of human system, and then integrate with the coordination degree of human water system, and finally got the evaluation result of human water harmony in Xi'an City from 2012 to 2021. The results show that the man-water coordination degree of Xi'an City is gradually improved, and the obstacle degree of each index to the coordinated development of man-water system in each year is clearly visible, and the harmony of man-water is also improved from less harmonious to harmonious level. The evaluation results of this method are consistent with the actual results and have good applicability. The identification of obstacle factors is instructive to further improve the harmony between human and water. [ABSTRACT FROM AUTHOR]

铸造过程中存在多种职业性有害因素可能损害劳动者的健康, 其中铸造工过敏性肺炎的病例少见报道。 报道 1 例因使用铸造用黏结剂导致过敏性肺炎的病例, 该患者在某铸造企业从事模具造型工作, 因“双眼刺痛、胸闷 10 d 余, 喘憋 2 d”入院, 其胸部 CT 表现为两肺弥漫性分布的小点片状略高密度灶, 肺功能显示限制性通气功能障碍、弥 散功能下降；动脉血气分析提示伴有低氧血症（动脉血氧分压 55 mmHg）。 经脱离工作环境, 糖皮质激素及西替利嗪 抗过敏治疗后, 患者临床症状及胸部 CT 小点片影消失, 肺功能及动脉血气分析指标恢复正常。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of ropivacaine combined with parecoxib sodium serratus plane block (SAPB) on postoperative oxidative stress and immune inflammatory response in patients undergoing thoracoscopic radical resection of lung cancer. Methods: According to the random number table method, 110 patients with lung cancer who underwent thoracoscopic radical resection of lung cancer in The Sixth Affiliated Hospital of Nantong University from January 2021 to April 2023 were divided into observation group (ropivacaine combine with parecoxib sodium SAPB, 55 cases) and control group (ropivacaine SAPB, 55 cases). The postoperative recovery, visual analogue scale (VAS) of pain at rest and cough, immune function, inflammatory response and oxidative stress were compared between two groups, and the incidence of adverse reactions during treatment was observed. Results: The postoperative spontaneous breathing recovery time, eye opening time and extubation time in observation group were shorter than those in control group (P<0.05). The resting VAS and cough VAS in observation group were lower than those in control group 12 h (T2)~48 h (T4) after operation (P<0.05). The levels of superoxide dismutase (SOD), CD3+, CD4+, CD4+/CD8+ in observation group were higher than those in control group at T3 time point. Malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and CD8+ were lower than those in control group(P<0.05). The adverse reactions in control group was 7.28%, and that in observation group was 10.92%, with no statistical difference(P>0.05). Conclusion: Ropivacaine combined with parecoxib sodium SAPB for thoracoscopic radical resection of lung cancer, which can effectively improve the clinical symptoms and immune function, reduce the body's inflammatory and oxidative stress. [ABSTRACT FROM AUTHOR]

BACKGROUND: Gait is one of the optimal indicators of functional status in older adults. Gait parameters are associated with adverse health outcomes in older adults. OBJECTIVE: To summarize and compare the practical value of gait parameters, and to review the progress of research on spatio-temporal parameters and the risk of adverse health outcomes in older adults. METHODS: PubMed, Web of Science, and CNKI were searched for relevant literature published from January 2010 to June 2023 using the search terms of “gait speed, walking speed, step length, cadence, step frequency, step time, walking base, aged and elderly” in English and Chinese, respectively. A total of 52 papers were finally included for the systematic review. RESULTS AND CONCLUSION: Currently, researchers have focused on three basic temporal-spatial parameters, namely, step speed, step length and step frequency, to explore their association with adverse health outcomes in older adults. Reduced gait speed in older adults may increase the risk of falls, all-cause mortality, and may be an independent predictor of all-cause mortality. Older adults with slow gait speed are at higher risk of cognitive decline, and may be the preferred gait parameter in assessing cognitive impairment in older adults. Older adults with slow gait speed are more likely to have debilitating or common chronic illnesses, and are at higher risk of hospitalization and public care. Step length is positively correlated with individual height and lower limb length, but age-induced shortening of step length is not related to height or lower limb length, and shortening of step length reflects reduced physical function in older adults, and shortening of step length is a risk factor for falls and cognitive decline in older adults. Stride frequency is often used as a measure of exercise intensity, and a stride frequency of ≥ 100 steps/minute is predictive of all-cause mortality, and slowing of step frequency may lead to a higher risk of falls, hospitalization and all-cause mortality in older adults. Changes in gait parameters are closely related to the level of physical fitness in older adults, and there may be a bidirectional relationship between the two. The results of the study will provide a theoretical basis for further improving risk screening in clinical populations, refining health risk assessment in the elderly, improving health protection and promoting active health in the elderly. [ABSTRACT FROM AUTHOR]

The marine-terrestrial interlaced zone serves as a crucial spatial hub linking the functional zoning of both land and sea areas. Optimizing the ecological function, economic function, and national security function of the marine-terrestrial interlaced zone is of significant importance for promoting the coordination between land and sea functional oriented zoning and achieving their mutual beneficial interaction. It also contributes to enhancing the economic, social, and environmental benefits, effectively allocating resources, and advancing social sustainability. Building upon the clarification of the current development status and characteristics of China's marine-terrestrial interlaced zone, the research systematically examines the key issues existing in the coordination between land and sea functional oriented zoning at the marine-terrestrial interlaced zone. Furthermore, it puts forward key construction tasks and development pathways aimed at enhancing the coordination functions of the marine-terrestrial interlaced zone. [ABSTRACT FROM AUTHOR]

Objective The aim is to study the deactivation mechanism of waste lubricating oil hydrogenation catalyst. Methods Taking NiMo/y-Al2O3 catalyst as the research object, the catalyst and oil before and after hydrogenation were characterized and analyzed, so as to find out the cause of catalyst deactivation. Results The catalyst showed superior initial hydrogenation activity, and the removal rates of sulfur (S), nitrogen (N) and chlorine (Cl) could reach 83.6%, 81.7%, and 99.7%, respectively. However, with the progress of the reaction, the activity of the catalyst decreased seriously from the 4th week. The characterization of the catalyst before and after the reaction showed that the specific surface area and pore volume of the catalyst decreased significantly after the reaction, and the silicon content in the catalyst composition increased significantly after the reaction, Conclusions The reason for the decrease of catalyst activity was neither the loss of active metal nanoparticles, nor the damage of catalysts microstructure, but with the hydrogenation reaction, the silicon in the oil was gradually deposited on the catalyst surface after hydrogenation, resulting in the active site being covered and unable to contact with the reactants. On the other hand, the accumulation of silicon in the fixed bed pipeline limited the mass transfer and heat transfer efficiency, and reduced the reactivity. [ABSTRACT FROM AUTHOR]

The structure characteristic of polyvinylidene fluoride membrane and graphene oxide was main introduced, respectively, and the advantages of organic-inorganic hybrid membrane were analyzed. The preparation method of GO/PVDF membrane were stated in detail, including solution casting method, electrospinning method, chemical grafting method, vacuum filtration method and so on. Based on the recent research status, the advantages and disadvantages of the above methods were analyzed. Then, the effects of GO on pore size, hydrophilicity and hydrophobicity, membrane flux, rejection, and mechanical properties of membrane were expounded. And the applications of GO/PVDF membrane in water treatment and other potential applications were reviewed. It was found that the solution casting method was simple and short, and the membrane produced by the chemical grafting method had a stable bond between each component and a long service time, while the membrane produced by the electrostatic spinning method had a large specific surface area and high porosity. The capillary action of the GO lamellar capillarity occurred, and the smaller particles would pass through the GO lamellar at a faster speed, the membrane flux was improved in macroscopic view. GO also improved surface finish, reduced the impurities blockage and pollution, and then improving service life of GO/PVDF membrane. The research direction and development trend of GO/PVDF membrane was prospected, thus would provide theoretical basis and technical support for the construction of efficient and stable PVDF separation membrane. [ABSTRACT FROM AUTHOR]

C5F10O has been put into practical application as a new environmental protection insulating gas that can replace SF6. Partial discharge and other faults will inevitably occur in the insulation equipment, resulting in the decomposition of C5F10O to produce harmful components such as weak insulation CF4, C2F6 and highly toxic CF2O, HF, etc. In order to ensure the safe operation of insulation equipment, these decomposition components need to be selectively removed by adsorption. The new graphene-like C3N material has a good application prospect in the field of gas detection. In this paper, the adsorption process of CuO-C3N on the main decomposition components CF4, C2F6 and highly toxic products CF2O and HF is calculated based on the first-principle. The adsorption energy, density of states, charge transfer amount, differential charge density and recovery time at different ambient temperatures are calculated and analyzed. The results show that CuO-C3N has good adsorption for HF, followed by CF2O, but it can not adsorb CF4 and C2F6. Therefore, CuO-C3N can be used as a high-performance gas adsorbent to remove the highly toxic HF gas in C5F10O insulation equipment. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to explore the photosynthesis-related cold-resistant genes in Mandragora chinghaiensis grown at high altitude and low temperature. [Method] Taking 0 °C low temperature stress Qinghai eggplant ginseng as the experimental material, the key time points were found through photosynthetic physiological experiments, and then transcriptomics analysis was carried out to screen photosynthetic related cold-resistant genes and perform real-time fluorescence quantitative analysis. [Result] The net photosynthetic rate, stomatal conductance, transpiration rate, maximum fluorescence, maximum photochemical efficiency of photosystem II, photochemical quenching coefficient, and electron transfer rate showed a gradual downward trend, while the intercellular CO2 concentration, initial fluorescence, and non-photochemical quenching coefficient showed an upward trend. Based on the comprehensive analysis of changes in photosynthetic and chlorophyll fluorescence parameters, the key time node was 12 hours. According to the analysis of transcriptome, seven genes were screened. Through qRT-PCR analysis, the expression of CP43 gene was up-regulated first and then down-regulated, showing an overall upward trend; The expression of CAB-8, САВ-11, СР24-10B, CH-02, FD-C2, and PSI-D2 genes was first down-regulated and then up-regulated, showing an overall downward trend. [Conclusion] The results of the study provided some theoretical support for the screening of photosynthesis-related cold resistance genes and the subsequent transgenic verification, the main purpose of screening genes has been achieved. [ABSTRACT FROM AUTHOR]

CF3I,as the most potential new environmental protection insulating gas of SF6,will produce C2F6,C2F4 and other strong greenhouse gases in cases of partial discharge, overheating and other defects in electrical equipment.In order to ensure the stable operation of power equipment, it is necessary to adsorb and remove the typical decomposition components of CF3I.In this paper, based on the first principle calculation method of density functional theory, the adsorption properties of C2F6 and C2F4 gas molecules by different amounts of Pt doped MoSe2 were investigated through adsorption indexes such as adsorption energy, adsorption distance, charge transfer and density of states. The results show that there are stable doping structures on the surface of MoSe2 doped with different amounts of Pt, and the conductivity of MoSe2 doped with Pt is effectively enhanced compared with that of intrinsic MoSe2. The adsorption effects of Pt doped MoSe2 on the decomposed components of CF3I are: Pt2-MoSe2>Pt-MoSe2>Pt3-MoSe2>Pt4-MoSe2. Pt2-MoSe2 shows strong chemical adsorption on C2F4 and weak physical adsorption on C2F6. Pt2-MoSe2 has selective adsorption to the decomposition components of CF3I, and hence is expected to be used as the adsorption and removal material of C2F4, a typical decomposition component of CF3I. [ABSTRACT FROM AUTHOR]

The phenomenon of urban growth and shrinkage coexist in China's rapid urbanization process, and urban shrinkage in the old industrial bases is a long-time disturbing problem. Based on the population and economic changes in cities of China's old industrial bases from 2009 to 2018, this paper analyzed the status and types of urban shrinkage and explored its influence mechanism. Results show that: (1) In general, the type of urban shrinkage of the old industrial base cities are mainly economic shrinkage, the type of population-economic shrinkage comes second, and pure population shrinkage is relatively few. The economic shrinkage and population-economic shrinkage cities mostly show the continuous spatial distribution, the population shrinkage type show the "dot" distribution features. (2) The shrinkage path goes as that economic decline precedes population loss in most old industrial base cities, and in few old industrial base cities, population loss led to economic decline. The cities in line with the former transformation path are mainly in central provinces and northeastern regions of China, while the cities in line with the latter transformation path are mainly in the northeast old industrial base. (3) The analysis of the influencing factors of old industrial base cities shows that birth rate, employment structure, industrial structure, opening-up policy, investment in science and technology affect the growth and shrinkage of urban population and economy in different directions and degrees. [ABSTRACT FROM AUTHOR]

人多能干细胞来源间充质干细胞 （hPSCs-MSCs） 具有与成体间充质干细胞 （MSCs） 相 似的分化功能, 还具有体外增殖能力强、来源丰富和免疫原性风险低等优点。hPSCs-MSCs 可应用于 免疫调节、抑制炎症、血管化和组织缺损修复及再生等多个领域, 使其成为在再生医学和组织工程中 应用最多的种子细胞。针对现有问题并结合相关文献, 对 hPSCs-MSCs 的分化、鉴定标准、纯化方法 和细胞性能等进行综述, 为 hPSCs-MSCs 在再生医学与组织工程领域中的应用研究提供理论依据。 [ABSTRACT FROM AUTHOR]

In the existing finite element models of ultrasonic shot peening, most of them ignore the influence of elastic and plastic deformation of the projectile on the numerical simulation results. There are few reports on the influence of the friction coefficient between the surface of the projectile and the surface of the sprayed material on the numerical prediction results of ultrasonic shot peening. Therefore, taking pure copper as the research object, the influence of friction coefficient and projectile deformation on pure copper by ultrasonic shot peening was studied by combining the ultrasonic shot peening experiment and numerical simulation process. Firstly, a three-dimensional finite element model of single ultrasonic shot peening was established based on ABAQUS platform. Then, the single ultrasonic shot peening experiment was designed, and the influence of shot peening distance on velocity was analyzed according to the experimental conditions. The experimental conditions were input into the simulation model, and the experimental and simulation results were compared from the aspects of shot velocity and indentation morphology. Finally, under the condition of friction coefficient of 0.1,0.2,0.3,0.4 and 0.5, the ultrasonic shot peening numerical simulation of pure copper specimens was carried out by respectively using rigid shot, elastic shot and elastic-plastic shot. The surface morphology and residual stress of the treated surface were analyzed. The obtained results show that when the friction coefficient between the shot and the pure copper is larger than 0.2, the influence of the friction coefficient on the morphology of indentations and residual stress formed by ultrasonic peening of pure copper is no longer significant. With the increase of the contact stiffness between the shot and the pure copper, the indentation size, the depth of the compressive residual stress field, the maximum compressive residual stress and the surface tensile residual stress induced by ultrasonic shot peening of pure copper increase accordingly. The research results have important guiding significance for the numerical modeling of ultrasonic shot peening. [ABSTRACT FROM AUTHOR]

Accurate prediction of gas reservoir productivity is directly related to the effective formulation of development plans. Geophysical logging can directly obtain reservoir information from the wellbore, and effectively characterize the parameters related to productivity, such as porosity, permeability, and oil saturation, so the industry pays much attention to the research on logging prediction of gas reservoir productivity. After systematically investigating the literature reports on gas reservoir productivity prediction methods at home and abroad, the main controlling factors were briefly described that affect the gas reservoir productivity, and four common reservoir productivity logging prediction methods were summarized, such as logging curve feature method, mathematical statistics method, gas production index method, artificial intelligence method. Finally, the applicability of gas reservoir productivity logging prediction methods was analyzed, and the future gas reservoir productivity logging prediction methods were prospected. Providing a certain theoretical reference for the future optimization of various gas field productivity prediction methods. [ABSTRACT FROM AUTHOR]

g3（green gas for gird） environmental protection gas（C4F7N/CO2 mixture）, as the most potential new environmentally friendly insulating substitute gas for SF6, has received extensive attention in recent years. Defects such as partial discharge and overheating are detected by analyzing the decomposed components in the g3 gas-insulated combined switchgear, which plays an important role in the evaluation and diagnosis of the operation status of power equipment. In this paper, the modification of Si atoms is proposed to improve the gas sensing and adsorption properties of MoS2. Based on the calculation method of density functional theory（DFT）, the intrinsic properties of MoS2 are explored through parameters such as adsorption energy, charge transfer, density of states and local density of states. The adsorption gas-sensing mechanisms of MoS2 and Si-MoS2 to the typical decomposition components of g3 gas—COF2, CF4, CF3CN. The analysis shows that Si atoms have a stable doping structure on the surface of MoS2. Compared with the intrinsic MoS2, the conductivity of MoS2 modified by Si atoms has been effectively enhanced; Si-MoS2 exhibits strong chemical adsorption to COF2 and CF4 gases, it is weak physical adsorption to CF3CN, the adsorption strength is CF4＞COF2＞CF3CN, and in the adsorption process Si-MoS2 always acts as an electron donor, transferring electrons to gas molecules; Si-modified MoS2 has selective adsorption to g3 gas decomposition components. It provides a theoretical basis for the development of MoS2 high-performance gas sensors for detecting CF4 and COF2 gases. The research results are also of great significance in reducing greenhouse gas emissions and improving the operational stability of GIS（Gas Insulated Switchgear). [ABSTRACT FROM AUTHOR]

Objective Optimize the latex perfusion technique and apply it to the construction of a murine craniofacial venous vascular model. Methods A total of nine 8-week-old male C57BL/6 mice weighing (25.0±1.3) g were randomly divided into three groups: 60% latex physiological saline group, 60% latex heparin group, and 30% latex heparin group. After completion of the perfusion, the specimens were immersed in 4° C formalin fixative for 24 h, followed by dissection, observation, and measurement of the extracranial blood vessel diameters. Results After 200 µL latex perfusion solution was injected into the external jugular vein, the supraorbital vein, infraorbital vein, temporal vein, retrofacial vein, masseter vein and external jugular vein were perfused in each group. After comparing the perfusion degree of the distal branches of blood vessels, sublingual vein and tip venule, it was found that the 30% latex heparin group had the best perfusion effect, followed by the 60% latex heparin group, and the 60% latex saline group had the worst perfusion effect. Conclusion The optimized latex perfusion technique can effectively infuse the veins in the head and face of mice, and this technique can provide a good reference for the study of the direction and morphology of facial veins in mice. [ABSTRACT FROM AUTHOR]

行心脏手术治疗的患者大多心功能较差, 对麻醉的耐受性低, 因此在手术过程中合理选择麻醉药物对心 脏疾病患者术中维持血流动力学稳定、减少应激至关重要. 瑞马唑仑是-种新型镇静药物, 麻醉诱导具有起效迅 速、恢复快、血流动力学稳定及呼吸抑制轻微等优点, 已先后批准用于程序性镇静及全身麻醉. 目前, 瑞马唑仑在心 脏手术患者全身麻醉中应用的相关研究较少且样本量较小, 但其在心脏瓣膜置换术、冠状动脉旁路移植术、经皮二 尖瓣钳夹术等心脏手术中被发现可维持患者术中循环稳定性且不良反应较少. 瑞马唑仑具有较高有效性及较好安 全性, 有望成为行心脏手术治疗患者全身麻醉的候选镇静新药. [ABSTRACT FROM AUTHOR]

BACKGROUND: Vascular transplantation is a hot research topic in vascular surgery at present. However, the detection of mechanical properties of preserved vascular wall needs to be solved urgently. OBJECTIVE: To summarize the techniques used by researchers to study arterial wall mechanics and the problems faced in this research direction. METHODS: The first author searched CNKI, WanFang, PubMed, and Google Scholar databases for relevant literature published from 2016 to 2022. The Chinese search terms were “aortic blood vessel, arterial wall, mechanics, elasticity, detection method” and the English search terms were “aortic vessels, arterial walls, mechanical model, elastic structure, mechanical testing.” The relevant literature about the distribution of mechanical structure of aortic blood vessel walls and relevant detection methods were retrieved. Finally, 54 articles regarding mechanical and micromechanical testing were induced for review. RESULTS AND CONCLUSION: The arterial wall is characterized by complex microstructure, which affects the mechanical properties of vascular tissue. The main components include collagen and elastin fibers, proteoglycans, vascular smooth muscle cells, and matrix. These components are often damaged during cryopreservation. Among them, vascular smooth muscle cells play a key role in the active mechanical response of the arteries, and collagen and elastin determine the passive mechanical response. After the treatment of vascular grafts, the technologies of detecting vascular wall skeleton damage still need to be further explored or summarized to obtain a set of more accurate methods, so as to evaluate vascular wall skeleton damage in multiple dimensions and help in [ABSTRACT FROM AUTHOR]

In this study, we analyzed the effectiveness of rural living environment improvements and upgrading mechanisms. Our results are conducive to consolidating and expanding the results of the 3-year action plan focused on comprehensively promoting the improvement in rural living environments in the new development stage. Based on the policy theme–effectiveness assessment–improvement path research framework, we analyzed the effectiveness of rural living environment improvements in Chongqing with the help of policy text analysis and structural equation modeling, explaining the mechanisms and proposing the pathways for these improvements, taking the policy theme as our guide and the six projects as the focus. The results showed that the rural living improvement in Chongqing focused on five major themes：infrastructure, economic development, living conditions, public services, and industrial development, with the number of relevant documents accounting for 18.9%, 16.3%, 19.8%, 25.6%, and 19.4%, respectively, of the total. From 1997 to 2020, the literature content showed phases in its characteristics from element supply, to structural improvement, to functional enhancement. The remediation effectiveness was higher in the main urban area, followed by in the Three Gorges Reservoir area, then the Wuling Mountains area, with comprehensive values of 2.70, 2.42, and 2.41, respectively. The effectiveness of housing remediation was highest in the first- and secondclass areas, whereas the effectiveness of biological resources recycling and regional culture remediation was higher in the third-class areas. The rural living environment improvement projects interacted with and promoted each other, and infrastructure development strongly contributed to the advancement of other projects. Therefore, the relevant departments should establish a systematic working idea for focusing on the goals, simultaneously implementing multiple measures, and coordinating governance to improve the quality of the rural living environment. [ABSTRACT FROM AUTHOR]

BACKGROUND: Cryopreserved allogeneic blood vessels have broad clinical application prospects in vascular transplantation and repair. Cryopreservation is a common method to achieve long-term preservation of allogeneic blood vessels. During cryopreservation, effective cryoprotectants are essential to prevent vascular tissue hypothermia damage and maintain cell viability. However, there is no consensus on the choice of the best cryoprotectant. OBJECTIVE: To summarize the cryoprotectants used in major vascular tissue banks in recent years and compare their clinical effects, thereby providing a reference for the application of cryopreservation of allogeneic blood vessels in the future. METHODS: The relevant literature included in CNKI, WanFang, PubMed, and Google Scholar databases from 2015 to 2022 was retrieved by the first author. The Chinese search terms were “allogeneic blood vessels, artery, vein, cryopreservation, cryoprotective agent, cryoinjury, vascular transplantation.” The English search terms were “cryopreservation, blood vessels, vascular allografts, arteries, veins, cryoinjury, cryoprotectants, cryoprotective agents.” The relevant literature at home and abroad on vascular cryoprotectants used in clinic and their short-term and long-term results were searched. Finally, 54 articles were selected for review. RESULTS AND CONCLUSION: (1) In the study of cryopreservation of blood vessels, a combination of permeable and non-permeable cryoprotectant is often used to reduce damage to the structure of the vessel wall through programmed cooling and rapid thawing. (2) Despite the toxic effects of dimethyl sulfoxide, tissue bank product lists in many countries do not include any cardiovascular tissue cryopreserved with cryoprotectant other than dimethyl sulfoxide alone. At present, there are still many clinical complications after cryopreservation of allogeneic blood vessels for vascular transplantation, and some are even fatal. (3) As an essential component of protective agent, dimethyl sulfoxide is very important to balance its toxic effect and protective effect. Finding a new type of cryoprotectant that is safe, non-toxic and free of xenogeneic antigens is the main direction of current research, which is very important for the clinical development of allogeneic vascular grafts. [ABSTRACT FROM AUTHOR]

BACKGROUND: Psoralen has a strong anti-osteoporotic activity and may have a restorative effect on chemotherapy-induced osteoporosis. OBJECTIVE: To explore the restorative effect of psoralen on the osteogenic differentiation of bone marrow mesenchymal stem cells in mice inhibited by cyclophosphamide and its mechanism. METHODS: C57BL/6 mouse bone marrow mesenchymal stem cells were isolated and cultured. Effect of psoralen on viability of bone marrow mesenchymal stem cells was detected by MTT assay. Osteogenic induction combined with alkaline phosphatase staining was used to determine the optimal dose of psoralen to restore the osteogenic differentiation of bone marrow mesenchymal stem cells inhibited by cyclophosphamide. The mRNA expression levels of Runx2, alkaline phosphatase, Osteocalcin, osteoprotegerin, and Wnt/β-catenin signaling pathway-related genes Wnt1, Wnt4, Wnt10b, β-catenin, and c-MYC were measured by RT-qPCR at different time points under the intervention with psoralen. The protein expression of osteogenic specific transcription factor Runx2 and Wnt/β-catenin signaling pathway related genes Active β-catenin, DKK1, c-MYC, and Cyclin D1 was determined by western blot assay at different time points under the intervention with psoralen. RESULTS AND CONCLUSION: (1) There was no significant effect of different concentrations of psoralen on the viability of bone marrow mesenchymal stem cells. The best recovery of the inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells caused by cyclophosphamide was under the intervention of psoralen at a concentration of 200 μmol/L. (2) Psoralen reversed the reduction in osteogenic differentiation marker genes Runx2, alkaline phosphatase, Osteocalcin and osteoprotegerin mRNA expression and Runx2 protein expression in bone marrow mesenchymal stem cells caused by cyclophosphamide conditioned medium. (3) Psoralen reversed the decrease in Wnt/β-catenin pathway-related genes Wnt4, β-catenin, c-MYC mRNA and Active β-catenin, c-MYC, and Cyclin D1 protein expression and the increase in DKK1 protein expression in bone marrow mesenchymal stem cells caused by cyclophosphamide conditioned medium. (4) The results showed that cyclophosphamide inhibited osteogenic differentiation of bone marrow mesenchymal stem cells in mice, and psoralen had a restorative effect on it. The best intervention effect was achieved at a concentration of 200 μmol/L psoralen, and this protective effect might be related to the activation of Wnt4/β-catenin signaling pathway by psoralen. [ABSTRACT FROM AUTHOR]

Urban-rural factors have been the most important elements to promote urban-rural linkage and regional cooperation in an urban-rural community of destiny. Various social resources are very necessary for social production and business activities in urban and rural areas. Rural development has been hindered and slowed by the dual system of urban and rural areas in China over a long time. However, only a single flow has been considered in the urban-rural factors. The current relationship between urban and rural areas has shifted from separation to integration. The flow of urban and rural factors has been characterized by the "multi-factors two-way freedom flow", particularly with the national policies leaning toward rural development, and the implementation of national strategies, such as "new urbanization", "rural revitalization", and " integrated urban-rural development ". Furthermore, agricultural production has gradually brought into the various promises of ecological conservation, leisure experience, and cultural inheritance. Rural development has entered an accelerated transformation period. The rural pluralistic values can be expected to realize for the rural revitalization strategy and transformation. It is very necessary to clarify the influencing mechanism of urban-rural factor flow for the rural multi-values in the urban-rural integrated development and all-round rural revitalization. Taking Chongqing in South China as the research area, this study aims to evaluate the flow of urban and rural factors, as well as the realization of rural multi-values. A systematic analysis was implemented on the correlation between rural and urban factor flow and rural multi-values, in order to explore the influence mechanism of rural factor flow, and then to empower the rural multi-values realization and the path of realizing rural multi-values under the flow of urban and rural elements. The results showed that: 1) The correlation logic law was established between rural-urban factor flows and the realization of rural multi-values. The comprehensive effects of population mobility, resource transfer, and social interaction between urban and rural systems were utilized to realize the multiple values in rural areas. Among them, the core, key and driving forces were the population flow, the resource transfer, and the social interaction, respectively. 2) There was a significant spatial difference in the factor flows between urban and rural areas. The population flow was relatively frequent with a spatial pattern of "high in the west and low in the east". There was a small difference in resource transfer, the high integration degree of urban and rural areas, the more interaction between urban and rural systems, and the highly active degree of resource transfer. There was a large difference between urban and rural development in southeast Chongqing and northeast Chongqing. There was a low integration degree of urban and rural, and the low active degree of resource transfer. Social interaction was less with the low activity, indicating a spatial pattern of "low-value series and high-value flower arrangement". 3) Rural multi-values were represented by supply, regulation, inheritance, and service values. The realization degree of rural multi-values was normally distributed with a spatial pattern of "high in the south and low in the north, and flower arrangement in the north". The distribution of flower arrangement in the main metropolitan area was mainly in the middle and low-value areas, while the northeast and southeast of Chongqing were in the middle and high-value areas. Low-value area was less. 4) The rural multi-values were attributed to the comprehensive effects of multiple factors, such as population flow, resource transfer, and social interaction. Population flow shared a significant positive correlation with the supply and adjustment value with a positive promotion, whereas a significant negative correlation was found with the inheritance value with a reverse inhibition effect. Resource transfer presented a significant positive correlation with the supply, adjustment, and service value, indicating a positive promoting effect. Social interaction showed a significant positive correlation to the adjustment and service value with a positive promotion effect, whereas, a significant negative correlation was found in the inheritance value with a reverse inhibition effect. 5) Rural multi-values should be started from three aspects: a new urban-rural relationship with the county territory as an important carrier, in order to establish an institutional channel for the free flow of factors with the full factor flow as the core. The rural value can be expected to realize with the high quality and multi-values in modern agriculture. [ABSTRACT FROM AUTHOR]

Aiming at the problem that the adaptive boosting regression threshold (AdaBoost. RT) algorithm has a constant threshold when judging the quality of training samples, and can not adaptively adjust the judgment criteria for each test sample, an improved AdaBoost. RT algorithm that can dynamically adjust the threshold was proposed. The adaptive adjustment of the threshold in the process of algorithm training and calculation was realized, which can improve the prediction accuracy and reduce the heavy workload caused by the selection of parameters. The four test functions were used to test the algorithm. The results show that the proposed algorithm can effectively use the differences between test samples, overcome the interference caused by large noise data, and achieve better performance than the original Adaboost. RT algorithm. The IEEE PHM 2012 data set was used to verify the effectiveness of the proposed method. The results show that the root mean square error of remaining useful life prediction obtained by the proposed method is reduced by 5. 18%, and the determination coefficient is increased by 3. 11% compared with the extreme learning machine (ELM). [ABSTRACT FROM AUTHOR]

BACKGROUND: Small-diameter blood vessel prosthesis has a wide application value in the treatment of peripheral vascular diseases, but the problem of graft failure due to early thrombosis needs to be solved. OBJECTIVE: To summarize research progress on early thrombosis and prevention of small-diameter blood vessel prosthesis. METHODS: The relevant literature published on CNKI, Wanfang, PubMed, and Google Scholar databases from 2000 to 2020 was retrieved by the first author. The Chinese search terms were “small-diameter blood vessel prosthesis, small-diameter tubular stents, tissue-engineered blood vessels, antithrombotic, thrombosis, hemocompatibility, hydrophilicity, endothelialization”. The English search terms were “small-caliber vascular graft, vascular tissue engineering applications, endothelialization, hemocompatibility, surface modification”. The relevant literature on the pathophysiological mechanism and prevention of small-diameter blood vessel prosthesis thrombosis in China and abroad was retrieved, and the surface modification and endothelialization of biological materials were taken as the inclusion criteria. Finally, 57 articles were selected for review. RESULTS AND CONCLUSION: Prevention of thrombosis is a hotspot and a difficulty in the study of small-diameter blood vessel prosthesis. The research progress at home and abroad in recent years shows that the early thrombosis of small-diameter blood vessel prosthesis is related to plasma protein adsorption and contact activation of coagulation factors. By improving the surface hydrophilicity, releasing antithrombotic substances, planting seed cells and target gene induction, the thrombosis of small-diameter blood vessel prosthesis has been improved to a certain extent, but it is still in the experimental stage, and there is still a certain distance from clinical application. Therefore, it is necessary to further explore or optimize a more suitable vascular material to provide more choices for clinical application. [ABSTRACT FROM AUTHOR]

In order to research the soil water and salt dynamic changes in the root zone of Halogeton arachnoideus and growth rules under different precipitation levels, a bucket-planting experiment was performed by taking water and vegetation cover as the controlling factor to explore the influence of H. arachnoideus growth on soil water and salt dynamics and the influence of soil water on H. arachnoideus growth. The results show that the soil moisture content increases with the increase of soil depth, showing an "inverse S" distribution, and EC decreases with the increase of soil depth, showing a "S" distribution. Compared with bare soil, the dynamic change of soil water and salt under the condition of vegetation growth is more complex. Under the condition of insufficient water, the phenomenon of salt accumulation is more likely to occur. The growth of H. arachnoideus was seriously inhibited in the extremely low-flow year, but there was no significant difference between the extremely high-flow year and high-flow year on plant growth. Therefore, compared with bare soil, the growth of H. arachnoideus significantly affects soil water and salt dynamics in its root zone. [ABSTRACT FROM AUTHOR]

The modified sludge derived biochar BC-Fe, BC-RM and BC-Ca was prepared by co-pyrolysis of metal oxide add让ives (Fe2O3, red mud and CaO) and sewage sludge at a mass ratio of 1 ： The influence of additives on the characteristics of the sludgebiochar, as well as the speciation distribution of heavy metals (Pb, Zn, Cu, Cr, Mn) were investigated ・ The ecological risk of the biochar was assessed based on the risk assessment code (RAC)・ The results showed that compared with unmodified biochar (BC), the specific surface area of the three modified sludge derived biochar increased by 58.08%, 189. 58% and 122.99%, respectively, and the microstructure performance of the sludge derived biochar was improved in the meantime・ The study also revealed that Fe2O3 prevented Zn escaping from sludge derived biochar during pyrolysis process・ In addition, compared with BC, the fraction of residual state (F4) of Zn, Pb, Cr, Mn and Cu in BC-Ca increased by 1L76%,13. 03%, 26. 96%, 5. 55% and 2. 11 %, respectively. Heavy metals investigated in the BC-Ca were all in a low risk cond让ion according to the RAC risk assessment standard. [ABSTRACT FROM AUTHOR]

我国社会经济不断发展的过程中，医疗事业也得到了突飞猛进的发展，药品是医疗行业发展中不可缺失 的重要一环，在药品生产和进入市场之前需要对药品的质量进行检验和控制，从而确保药品生产质量可以满足安全有 效，质量可控的质量属性要求。但是，在实际开展药品检验的过程中，还存在着一定的影响因素，如检验人员能力不 足，检验仪器精度以及样品选取等存在不当会导致整个检验环节受到严重影响，出现药品检验质量风险，检测结果的 准确性存在不足，不仅会影响到药品上市许可持有人、生产企业的经济效益，甚至可能会导致不符合质量标准的药品 流入到市场中，给患者的生命健康带来威胁。基于此，本文对药品检验质量风险进行了分析和探讨，并提出了几项药 品检验质控优化措施，以供参考。 [ABSTRACT FROM AUTHOR]

[Objective/Meaning] The current situation of different types of rural-urban elderly migrants was analyzed in this paper, in order to provide decision-making reference for guaranteeing the rights and interests of the floating elderly population and promoting the citizenization of the agricultural transferring population. [Methods/Procedures] Based on the dynamic monitoring survey data of the floating population in China in 2017, the binary logistic regression model was used to reveal the long-term residence intention and influencing factors of different types of elderly floating population. [Results/Conclusions[ The study found that: (1) The long-term residence intention of the elderly floating population decreased in the order of the types including the non-local elderly care service, other type, the accompanying transferring of family members, and farmers ’doing business or seeking jobs in cities. (2) The long-term residence intention of the elderly floating population had the characteristics of obvious spatial agglomeration. The high-value areas were mainly distributed in the northeast and western regions of China, while the low-value areas were concentrated in the eastern region of China. (3) The type of household registration, the duration of inflow, the housing nature, the willingness to integrate and family difficulties were the main factors that determined the residence intention of all types of elderly floating population. In addition, there were significant differences in the dominant factors affecting the long-term residence intention of different types of elderly population. [ABSTRACT FROM AUTHOR]

Objectives The study aims to facilitate China’s hydrogen energy industry and improve the quality of hydrogen, as well as solving the technical problem of argon impurity quantification due to the difficulty of effective separation of oxygen and argon in hydrogen quality analysis method. Methods An analytical method for accurate determination of trace argon impurity in hydrogen based on chromatographic correction factor is established. Firstly, the helium ionization gas chromatographic method is established through the self-prepared reference materials of argon in hydrogen and oxygen in hydrogen, along with the correction factors of oxygen and argon on the helium ionization gas chromatograph are researched; Secondly, the response relationship between oxygen and argon is calculated, while the long-term stability of which is investigated; Thirdly, by using the micro oxygen analyzer, the oxygen impurity content in hydrogen is measured. Results The argon impurity content in hydrogen is accurately determined according to the response relationship between oxygen and argon. Conclusions A new method combined helium ionization gas chromatography with electrochemical method is first proposed for the determination of trace argon impurity in hydrogen. It provides the guarantee on the accuracy data of argon content in hydrogen with the advantages of simplicity, strong operability and wide determination range, making up for the deficiency of argon impurity analysis method. Furthermore, the application of this method has great potential on the evaluation of the hydrogen quality. [ABSTRACT FROM AUTHOR]

Objective：To compare the cutting abilities and shaping abilities of three kinds of single formed nickel-titanium instruments for the simulated curved root canals, and to provide the basis for their clinical applications. Methods：A total of 40 single curved resin simulated root canals were selected and randomly divided into Reciproc Blue group, WaveOne Gold group, M3-L group, and ProTaper Gold group, and there were 10 single curved resin simulated root canals in each group. The simulated root canals in each group were prepared according to the user manuals, and the preparation time, difference in weights of simulated root canals before and after preparation, difference of bending angles of simulated root canals, apical deviations, removal amounts of internal and external resin, centering ratios of simulated root canals in various groups were recorded. Results：The preparation time of the simulated root canals in WaveOne Gold group was shorter than those in the other three groups (P<0.05), and the preparation time of the simulated root canals in ProTaper Gold group was longer than those in the other groups (P<0.05). There was no significant difference in wieight of the simulated root canals among four groups before and after preparation (P>0.05). The differences of bending angles of the simulated root canals in M3-L group before and after preparation was smaller than those in the other three groups (P<0.05). After preparation, the removal amount of internal resin of the apical zone (1－4 mm)was larger than extermal resin (P<0.05), and the removal amount of external resin of the middle zone (5－8 mm)was larger than internal resin (P<0.05)；at the positions 1, 3 and 6 mm from the apical foramen, the differences between the centering ratios of the simulated root canal in ProTaper Gold group and 1 was the largest, which was larger than those in the other three groups (P<0.05), and the differences between the centering ratio of the simulated root canals and 1 at each observation point in the other groups were not statistically significant (P>0.05). Conclusion：Reciproc Blue, WaveOne Gold and M3-L single formed nickel-titanium instruments can keep the shape of root canals better, and have better preparation efficiencies and center positioning ability than the ProTaper Gold multi-file system. Domestic single nickel-titanium instrument M3-L can better maintain the original curvature of the root canals. [ABSTRACT FROM AUTHOR]

A coagulation factor 8（F8）gene knockout mouse model was constructed based on CRISPR/Cas9 technique and its phenotype was verified. sgRNA target sites were designed according to exon 1 non-coding region to exon 26 downstream sequences of F8 gene，the sgRNA was obtained from in vitro transcription and mixed with mRNA of encoding Cas9. F0 generation positive knockout mice were obtained by microinjection of fertilized eggs. F8 -/- gene knockout homozygous mice（F8-/- mice）were obtained by breeding and genotype identification. The expression of F8 gene at mRNA level in main tissues was detected by reverse transcription PCR（RT-PCR），the protein expression of F8 gene in plasma was detected by enzyme-linked immunosorbent assay（ELISA），and the coagulation function of F8 knockout mice was detected by activated partial thromboplastin time（APTT）and fibrinogen content（FIB）. PCR and sequencing results showed that F8 gene was knocked out successfully in mouse genome，and RT-PCR and ELISA results demonstrated that the expression of F8 in F8-/- mice was significantly lower than that in wild-type mice（WT mice）（P < 0.0001，P<0.01）. APTT，FIB and drop blood test results revealed that the plasma coagulation time of F8-/- mice was significantly longer than that of WT mice. F8-/- mice had severe coagulation disorder phenotype， which restored to normal levels after administration of human factor VIII. The F8 gene knockout mice model is successfully constructed by CRISPR/Cas9 technique and its phenotype is preliminarily verified，which confirms that the deletion of F8 gene can lead to coagulation dysfunction. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors for early recurrence of resectable pancreatic cancer and the establishment and application of a grading system. Methods A retrospective case-control study was conducted among 303 patients with resectable pancreatic cancer who underwent radical resection in Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, from March 2015 to June 2021, and according to the presence or absence of early recurrence (within 6 months after surgery), the 283 patients directly operated on were divided into early recurrence group with 95 patients and non-early recurrence group with 188 patients; 20 patients who received neoadjuvant therapy before surgery were enrolled as neoadjuvant therapy group. Observation indicators included general information, preoperative imaging data, preoperative laboratory data, routine blood test/blood biochemistry and derived indicators, tumor markers, and coagulation markers, and follow-up was conducted to observe recurrence-free survival. The t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups. A multivariate Logistic regression analysis was used to investigate the risk factors for early recurrence in patients with pancreatic cancer, and the receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of each indicator. The Kaplan-Meier curve was plotted, and the Log-rank test was used for comparison of recurrence-free survival time between groups. Results The univariate analysis showed that compared with the non-early recurrence group, the early recurrence group had significantly lower body mass index (BMI) and triglyceride and significantly higher CA19-9, CA242, CA125, and plasma fibrinogen (all P < 0.05). The multivariate logistic regression analysis showed that BMI (odds ratio [OR]=1.150, 95% confidence interval [CI]: 1.038-1.273, P=0.007), plasma fibrinogen (OR=2.513, 95%CI: 1.355-4.663, P=0.003), and CA242 (OR=2.482, 95%CI: 1.067-5.774, P=0.035) were independent risk factors for early recurrence in patients with resectable pancreatic cancer. BMI, CA242, and plasma fibrinogen were included in the grading system, with a cut-off value of 23.00 kg/m², 30.0 U/mL, and 4.00 g/L, respectively. BMI < 23.00 kg/m² was counted as 1 point, otherwise it was counted as 0 point; CA242≥30.00 U/mL was counted as 1 point, otherwise it was counted as 0 point; plasma fibrinogen ≥4.00 g/L was counted as 1 point, otherwise it was counted as 0 point; the total score was 0-3 points. The patients in both the early recurrence group and the non-early recurrence group were scored, and the results showed that the early recurrence group had a significantly higher score than the non-early recurrence group [2(0-3) points vs 1(0-3) point, Z=-5.339, P < 0.001]. The Kaplan-Meier curve analysis showed that there was a significant difference in time to recurrence between groups (χ²=28.116, P < 0.001), and the higher the score, the shorter the expected time to recurrence. The patients with 3 points were defined as high-risk group and those with 0-2 points were defined as low-risk group, and the early recurrence rate was 84.6% in the high-risk group and 31.2% in the low-risk group. Conclusion The grading system based on BMI, plasma fibrinogen, and CA242 can reliably predict postoperative recurrence. [ABSTRACT FROM AUTHOR]

Pancreatic cancer is known as the " king of cancer". The incidence and mortality of pancreatic cancer are increasing year by year worldwide. The prognosis of pancreatic cancer is very poor, and the effect of existing diagnosis and treatment methods is limited. The Oncologist Branch of the Chinese Medical Doctor Association, the Pancreatic Disease Special Committee of the China International Exchange and Promotive Association for Medical and Health Care, and the Abdominal Tumor Special Committee of the China Medical Education Association convened relevant experts to put forward useful suggestions for clinical reference on nine aspects of home management of patients with pancreatic cancer, including condition communication, follow-up, nutritional support, cancer pain management, psychological adjustment, ascites management, jaundice management, and daily food management. The aim is to improve the quality of life and prolong the survival time of patients with pancreatic cancer. [ABSTRACT FROM AUTHOR]

：In this study, we aimed to investigate the effect of amount of irrigation water under gravel-sand mulch conditions on hydrothermal parameters of soil and fruit yield of date palm forests in fallow gravel-sand mulched field. The field experiment was conducted in an arid zone in central Ningxia. To investigate the effects of gravel-sand mulch and irrigation on soil temperature, soil water storage, jujube fruit yield, and water use efficiency, we used two types of mulch（gravel-sand mulching（M）and bare soil（N））and three different amounts of irrigation water（low water：180 mm（W1）, medium water：210 mm（W2）, and high water：240 mm（W3））. The results showed that gravel-sand mulching increased the soil temperature at a depth of 0~10 cm by 0.8~3.1 ℃ compared with that of bare soil. The soil warming period（10：00—14：00）after gravel-sand mulching was significantly shorter than that of bare soil（8：00—14：00）, and the warming rate was 0.4 ℃·h-1 faster than that of the bare soil treatment. The method of mulching and the amount of irrigation water had a significant effect（P<0.05）on the amount of soil water stored at a depth of 0~80 cm during the entire fertility period of the jujube trees, and the gravel-sand mulching treatment increased by 10.97% on average with the amount of soil water stored compared with that of the bare soil treatment. The highest increase was 14.54% at the leaf bud stage, when the soil water content was low. The growth index, yield, and water use efficiency of jujube trees under gravel-sand mulch conditions were higher than those under bare soil, and the yield from high to low was W3>W2>W1, which increased by 5.99%, 10.54%, and 26.79%, respectively, compared with that of the bare soil treatment, with the highest water use efficiency of MW2 being 1.55 kg·m-3 . In condusion, the MW2 treatment is a suitable planting pattern for date palm forests on fallow and gravel-sand mulched field in the central arid zone of Ningxia. [ABSTRACT FROM AUTHOR]

To investigate the curative effect of sinus enlargement and opening partial middle turbinate resection combined with nerve branch block in patients with refractory sinusitis. Methods　A total of 60 patients with refractory sinusitis admitted to the Otolaryngology Department of The Second People’s Hospital of Qujing city from May 2019 to May 2021 were selected and divided into 2 groups by random number table method. The control group （n = 30 cases） was treated with sinus enlargement and middle turbinate resection，while in the study group （n = 30 cases），sinus enlargement，middle turbinectomy and nerve branch occlusion were performed. The effective rate， recurrence rate， visual analogue scale （ VAS）， clinical symptom score and clinical level indexes of the two groups were observed and analyzed. Results　The effective rate of operation in the study group was higher than that in the control group，and the recurrence rate was lower than that in the control group. The differences were statistically significant （P = 0.021，0.007）. VAS scores of 3 months，6 months and 1 year after the operation in the study group were lower than those in the control group and the differences were statistically signi icant （P = 0.041，0.039，0.017）. The clinical symptom score of the study group was lower than that of the control group and the differences were statistically significant （P = 0.028，0.037，0.010，0.022）. EOS，IFN-γ and basophils in the study group were better than those in the control group，and the differences were statistically significant （P = 0.029，0.003，0.045）. Conclusion　The treatment of refractory sinusitis with sinus enlargement， middle turbinate resection and nerve branch block can relieve the clinical symptoms and reduce the recurrence rate， which is worthy of application. [ABSTRACT FROM AUTHOR]

Objective: To study the regulation of electroacupuncture Zusanli (ST36) on pulmonary inflammatory response and pathological injury in septic rats, and to provide a new theoretical basis for the clinical treatment of sepsis. Methods: A total of40 adult male SD rats were divided into sham eptic (SHAM group), sepsis group (CLP group), sepsis + sham electroacupuncture group (non-meridian and non-acupoint group) and sepsis + electroacupuncture Zusanli (ST36) group (Zusanli group) according to random number table, with 10 rats in each group. Except for the first group, all the other rats were treated with cecal ligation and perforation (CLP) to prepare the sepsis rat model. Before modeling, the sepsis + sham electroacupuncture group was given by electroacupuncture at non-meridian and non-acupoint points, and the sepsis + electroacupuncture Zusanli (ST36) group was given by electroacupuncture at Zusanli (ST36) points. The parameters of electroacupuncture were density wave, 2 Hz, 1 mA, lasting 30 min for 5 consecutive days. The bronchoalveolar lavage fluid was collected 24 h after surgery, the right lung was collected to measure the wet-dry weight ratio, the lower lobe of the left lung was collected to observe the pathological changes, and the upper lobe of the left lung was collected to detect the inflammatory factors TNF-α, IL-1β, IL-6 and HMGB1. Results: Compared with SHAM group, lung tissue in CLP group showed significant pathological damage (all P<0.05), inflammatory factors were significantly elevated (all P<0.01), and high mobility group protein 1 (HMGB1) was significantly increased (all P<0.05). After electroacupuncture Zusanli (ST36) treatment, the lung pathological injury of sepsis rats was significantly reduced(P<0.05), inflammatory factors were significantly decreased(all P<0.01), and HMGB1 was significantly decreased (P<0.05). There were no significant differences in lung tissue pathological injury, inflammatory factors and HMGB1 between CLP group and non-meridian and non-acupoint group (all P>0.05). Conclusion: Electroacupuncture in Zusanli (ST36) can reduce the Pulmonary inflammation and tissue damage in septic rats, and reduce the level of lung HMGB1. [ABSTRACT FROM AUTHOR]

The classification of nano flooding technology and the research status of micro and macro flooding mechanisms are reviewed ・ The five major applications of intelligent nano flooding technology are introduced, and the advantages of this technology and conventional flooding technology are compared・ The performance effect, cost, safety and environmental protection analysis of the challenges faced by intelligent nano flooding technology, and give forwardoking development suggestions. [ABSTRACT FROM AUTHOR]

In this paper, Standard ke, RNG ke and Realizable ke are three turbulence models of high Reynolds number are used to simulate the CAARC model under different meshing, different wind fields environment, and different wind directions. The numerical simulation results were compared with wind tunnel test data at home and abroad, the conclusions are as follows: (1) The precision of the building boundary layer grid model has an important influence on the simulation results. When the best grid model is selected for simulation, the RMSE of RNG ke model is equal to that of wind tunnel test data, and the root mean square error of RNG model is 50% - 70% less than that of sparse grid model, and the error of other two models is about 40% - 50%. (2) In the case of B-type and D-type wind farms, the variation area and trend of the average wind pressure coefficient obtained by RNG ke model are basically the same, and there is no obvious difference, while the variation trend of the other two models is in different wind farms. The change range of environment is also very different, the difference is mainly reflected in the crosswind side and leeward side of the building. (3) On the leeward side, the average error of the model is about 90% smaller than that on the leeward side, and about 5% lower than that of the other two models. Generally speaking, under different simulation conditions, the accuracy, stability and regularity of the results obtained by RNG ke model are higher than those of the other models. [ABSTRACT FROM AUTHOR]

选择性腰神经根阻滞（SNRB）是指在各种影像学设备定位引导下，根据需要选择性地对腰段神经根进行穿 刺阻滞的微创技术。传统C臂X线和CT引导下SNRB对于腰神经参与支配区域的神经病理性疼痛具有很高的诊断价 值。近年来，随着超声技术不断发展，超声引导下SNRB因其具有准确、安全、有效、实时等优势，逐渐用于下肢手术围 术期的麻醉与镇痛，尤其适用于老年患者。总之，SNRB为临床麻醉与镇痛提供了一种新的选择。 [ABSTRACT FROM AUTHOR]

For the poor adhesion of superhydrophobic properties, the stability of surface superhydrophobic properties is improved. The effects of groove depth, bulge width and groove depth on contact angle were studied by 0. 05, 0. 10, 0. 15, 0. 20 mm micro-milling cutter on red copper surface, and low surface energy modification with stearic acid and alcohol mixture solution. The maximum contact angle is 157. 4° when the groove width is 0. 20 mm and the minimum contact angle is 81. 2°. With the increase of protruding width, the contact angle increases greatly first, then decreases slowly. When the protruding width is 0. 07 mm, the maximum contact angle is 159. 2°. The minimum contact angle is 144° when the groove width is 0. 20 mm. With the increase of groove depth, the contact angle will increase and then decrease. When the groove depth is 0. 03 mm, the maximum contact angle is 168°. The minimum contact angle is 101. 7° when the groove depth is 0. 02 mm. A large number of irregular microstructures will be found. When the surface of liquid and workpiece is in contact with each other, the surface becomes smaller and the contact angle becomes larger. [ABSTRACT FROM AUTHOR]

This study aims to explore the effect of flooding and waterlogging at the jointing stage of summer maize on the formation mechanism of yield in the Huaibei plain. Taking Denghai 605 as the test material, two treatments of water stress (including flooding and waterlogging) were carried out in a field experiment in the Wanbei experimental station of Anhui Agricultural University in 2018 and 2020. The normal water supply was also used as the control (CK). The parameters were analyzed, such as growth process, photosynthesis traits, dry matter accumulation, lodging resistance traits, male-female interval, ratio of leaf to grain, and yield of summer maize. The results showed as follows. 1) The duration from the jointing to silk and anthesis-silking interval were significantly (P<0.05) increased, compared with the CK, and the flooding treatment was significantly (P<0.05) greater than the waterlogging treatment. 2) The leaf area per plant, the chlorophyll content, and net photosynthesis rate (Pn) from the big trumpet to dough stage significantly (P<0.05) decreased in the flooding treatment, compared with the CK. The leaf area per plant from big trumpet to dough stage significantly (P<0.05) decreased in the waterlogging treatment, compared with the CK. The chlorophyll content and net photosynthesis rate only at big trumpet stage significantly (P<0.05) decreased in the waterlogging treatment, compared with the CK. 3) The dry matter accumulation of leaf, stem, ear, and whole plant from the big trumpet to maturity were significantly (P<0.05) reduced in the flooding and waterlogging treatment, compared with the CK. The dry weight of the whole plant is the most critical physiological index affecting the yield, and the rates of decrease were 53.99% and 23.65% for the dry matter accumulation of whole plant in the flooding and waterlogging treatment, respectively.4) The stem diameter and puncture strength were significantly (P<0.05) reduced in the flooding treatment compared with the CK. Meanwhile, the lodging rate significantly (P<0.05) increased in the flooding treatment, where the rate of increase was 78.53% compared with the CK. 5) The empty rods rate significantly (P<0.05) increased in the flooding and waterlogging treatment compared with the CK. The number of grains per ear is the most critical yield component factor affecting yield, and the grains number per ear and yield of summer maize significantly (P<0.05) decreased in the flooding and waterlogging treatment, compared with the CK, where the rates of decrease for the grain number per ear were 44.48% and 30.61%, respectively, whereas, those for the yield were 57.26% and 34.68%, respectively. The 1000-grain weight and the leaf area and number of grains per leaf were significantly (P<0.05) reduced in the flooding treatment, while, that significantly (P<0.05) increased in the waterlogging treatment, compared with the CK. The findings can provide a theoretical and technical support to the decision-making on the summer maize production in areas prone to the waterlogging disaster. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression level and potential clinical value of serum HBV RNA in HBeAg-positive chronic hepatitis B（CHB） patients at different periods. Methods A total of 61 CHB patients who attended the outpatient and inpatient services of Department of Hepatology, Hangzhou Xixi Hospital, from August 2019 to December 2020 were enrolled, and according to the antiviral therapy for HBeAg-positive CHB patients, they can be divided into group A with untreated HBeAg-positive CHB（HBeAg+ and HBV DNA+） patients, group B with treatment-experienced patients before HBeAg seroconversion（HBeAg+ and HBV DNA-）, and group C with treatment-experienced patients after HBeAg seroconversion（HBeAg-and HBV DNA-）. Peripheral blood HBV RNA load was measured at different periods, and its correlation with HBsAg and HBV DNA was analyzed. The t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between groups; a Pearson or Spearman correlation analysis was used to describe the correlation between two variables. Results The positive rates of HBV RNA in these three groups were 100%（22/22）, 88.2%（15/17）, and 22.7%（6/22）, respectively. In group A, HBV RNA was positively correlated with HBsAg and HBV DNA（r=0.612 and 0.922, both P<0.01）, while in groups B and C, there was no correlation between HBV RNA and HBsAg. Group B had significantly higher levels of HBV RNA and HBsAg than group C（Z=-4.44 and-2.41, both P<0.05）. The HBV DNA-positive group had a significantly higher level of HBV RNA than the HBV DNA-negative group（Z=-6.16, P<0.01）. Conclusion After HBV DNA clearance achieved by antiviral therapy with nucleos（t）ide analogues in CHB patients, serum HBV RNA can still be detected in some of these patients. Since HBV RNA only comes from cccDNA in the liver, it can better reflect viral replication activity in the liver than HBV DNA and thus has a certain clinical value in the management of CHB patients. [ABSTRACT FROM AUTHOR]

Vibration frequency and energy in CNC milling process can indirectly reflect the influence of vibration on the surface quality of milling process. First,the principle of vibration test system is introduced,and then the frequency and energy data of milling system are tested by milling 6061-T651 aluminum alloy U slot. According to the obtained detection data,the vibration frequency and energy peak of milling machining under different spindle speed,different feed speeds and different milling depth are analyzed respectively. Analysis results show that when the spindle speed is less than 1 400 r/ min,the peak vibration energy increases and the cutting surface quality becomes worse. To improve the surface quality of machining workpiece,if the feed quantity per tooth is more than 0. 037 mm,the corresponding spindle speed is 1 400 r/ min,the vibration amplitude of nonlinear change will increase greatly. It is due to the small spindle speed and the increase of feed quantity per tooth,and results in the impact effect caused by the excessive torque borne on the machine tool spindle. With the increase of feed speed, the peak energy also increases gradually,indicating that the vibration increases with the increase of feed speed. The faster the feed speed,the greater the vibration of the system. The greater the depth of milling,the greater the vibration amplitude of milling and the worse the surface quality of milling. Thus it is necessary to reduce the milling depth in order to improve the surface quality. [ABSTRACT FROM AUTHOR]

In order to study the effects of preload on the residual stresses induced by surface mechanical rolling treatment（SMRT）, the three-dimensional finite element models in conjunction with a novel computation framework coupling the explicit dynamics and implicit statics were developed to simulate the process of surface mechanical rolling of AISI 4340 steel under preload. At first, the elastic deformation was produced in the finite element model to be surface mechanical rolled by applying the displacement load. Secondly, the displacement-preloaded side was completely constrained for freezing the displacement-induced elastic deformation. On this basis, the surface mechanical rolling of the finite element model with the freezing elastic deformation was then carried out. Lastly, the residual stresses induced by surface mechanical rolling treatment were comparatively studied after the freezing elastic deformation was released. The obtained results show that the surface mechanical rolled materials can produce the unfavorable tensile residual stresses in the treated surface, and the maximum compressive residual stresses can be reduced if the preloading direction is opposite to the direction of rolling pressure. The compressive residual stresses in the subsurface of surface mechanical rolled materials can be further reduced when the preload is released. It is therefore necessary to avoid the preload in the surface mechanical rolling process. [ABSTRACT FROM AUTHOR]

The Lucaogou Formation reservoir of Jimu sar shal e oil in Xinjiang Oilfield Company has the characteristics of low porosity and low permeability, no developmental edge and bottom water, thin oil layer with well developed bedding plane, and thick oil quality. In the early stage, the open-hole packer completion fracturing technology had realized the new production and high yield of some single wells, but there was a lack of effective refracturing technology for open-hole packer completion horizontal wells. Aiming at the above problems, the research on multi-stage temporary plugging and refracturing technology was carried out. Through the experimental study on the key temporary plugging agent, it was found thee the temporary pluggin agent had t he advantages of pressure bearing of more than 60 Ml'a and dissolution rate of less t h an 3 % wit h in 6 days. The field test results of the selected temporary plugging agent it was good, and the oil output of typical Ji after fracturing was 47.5 t per day. This technology breaks the traditional idea that open-hole packer horizontal wells cannot be re fractured, and provides a reference for similar reservoirs and similar processes at home an d abroad. [ABSTRACT FROM AUTHOR]

Objective·To study the role and mechanism of mucin 1 (MUC1) in the pathogenesis of HER2-positive breast cancer. Methods·Virus infection technology was employed to construct MT2/MUC1 and MT2/Vec/MUC1-CD overexpression cell lines; Western blotting was used to detect the expression level of relative proteins; the ability of cell proliferation, migration and sphere formation were detected by using cell counting kit-8 (CCK-8), colony formation, wound healing, transwell and sphere formation experiments respectively; inhibitor 6-AN was used to inhibit glucose-6-phosphate 1-dehydrogenase (G6PD) activity, and the proliferation of breast cancer cells was detected by CCK-8. GEPIA and Kaplan-Meier Plotter database were analyzed to figure out the relationship of HER2, MUC1 and G6PD expression with the survival of breast cancer patients. Results·Overexpression of MUC1 or MUC1-CD promoted the proliferation, clone formation, migration and sphere formation of MT2 HER2-positive breast cancer cells, as well as elevating the protein level of G6PD. Inhibition of G6PD activity significantly reduced cell proliferation induced by MUC1 and MUC1-CD. High level of G6PD protein in breast cancer tissues is associated with significantly lower survival of breast cancer patients. Conclusion·MUC1 may promote the progression of HER2-positive breast cancer by up-regulating the expression of G6PD, suggesting that inhibition of the pentose phosphate pathway may be a target for the treatment of HER2-positive breast cancer. [ABSTRACT FROM AUTHOR]

[Objective] The study aimed to explore the species diversity of entomogenous fungi and their distribution characteristics along the altitude, which can gradient provide a scientific basis for the development, utilization and protection of entomogenous fungi resources along the Nujiang River in the Gaoligong Mountain. [Method] The samples of soil were collected along the Nujiang River (800-1500 meters) from Baoshan in the south section of Gaoligong Mountain to Bingzhongluo in the north section of Gaoligong Mountain. Then, entomogenous fungal strains were isolated and identified according to the morphological characters and multigene phylogenetic analysis. Finally the species diversity and vertical distribution characteristic of entomogenous fungi were analyzed. [Result] A total of 623 fungal strains were identified, including 18 species from seven genera of four families. Metarhizium (398 strains of 9 species) and Beauveria (133 strains of 3 species) were the dominant genera. Metarhizium brunneum and Beauveria bassiana were the dominant species. Entomogenous fungi were distributed in the soil of all elevation gradients. The diversity indices of entomogenous fungi showed a decreasing trend with increasing altitude. The Shannon-Weiner index (1.8117), Simpson index (0.7758) and evenness index (0.7868) of entomogenous fungi in Baoshan section (800 900 meters) were the highest, and the dominance index (0.2242) was the lowest. The Shannon-Weiner index (1.2079), Simpson index (0.5200) and evenness index (0.5037) of entomogenous fungi in Gongshan section (1400-1500 meters) were the lowest, and dominance index (0.4800) was the highest. Cluster analysis showed that the entomogenous fungi along the Nujiang River in the Gaoligong Mountain were categorized into wide-area distribution species and narrow-area distribution species. Redundancy analysis showed that soil humidity and soil temperature were main factors which affected the diversity and abundance at the genus level of entomogenous fungi along the Nujiang River in the Gaoligong Mountain. [Conclusion] Entomogenous fungi species diversity in the soil along the Nujiang River in the Gaoligong Mountain is abundant and has certain vertical distribution characteristics. Therefore, it is necessary to strengthen the protection of entomogenous fungi species resources in this area. [ABSTRACT FROM AUTHOR]

This study explored ways to improve the efficiency of rural domestic waste sorting treatment from the perspective of the participation of farmers. Firstly, we theoretically analyzed the participation of farmers in rural domestic waste sorting treatment and the associated impact on treatment efficiency. Second, based on the2019survey data from187villages in Hangzhou City, Zhejiang Province, the DEA（Data envelopment analysis）model was used to measure the efficiency of rural domestic waste sorting treatment with the participation of farmers. The Tobit model was used to analyze the impact of the participation of the farmers on treatment efficiency. Finally, the influence of the participation of farmers on the efficiency of rural domestic waste sorting treatment was further analyzed from the input–output perspective. The results indicated a low average rural domestic waste sorting treatment efficiency of0.58. The direct participation behaviors of farmers, such as the waste sorting awareness rate and supervision behavior, had a significant positive impact on the efficiency of rural domestic waste sorting treatment. Additionally, indirect participation, such as payment behavior, had a significantly negative impact on efficiency. The direct and indirect participation of the farmers affected input and output and impacted the efficiency of rural domestic waste sorting treatment. Based on the research conclusions, local governments should propose relevant measures to improve the efficiency of rural domestic waste sorting treatment. These measures could include reasonably increasing waste sorting treatment, strengthening publicity and education related to domestic waste sorting, guiding the domestic waste sorting of farmers, and establishing incentive mechanisms for farmers to participate in domestic waste sorting. [ABSTRACT FROM AUTHOR]

BACKGROUND: The main types of copper deposits are porphyry and skam types. Dacite porphyry is a rock type commonly developed in the porphyry Cu - Mo - Au system. The rock can be used for prospecting sign and ore - forming rock when there is well - developed hydrothermal alteration. The Dabaoshan deposit is currently the largest copper polymetallic deposit in South China Block. Previous studies have shown that the dacite porphyry of the mining area is not only the ore - forming parent rock, but also a favorable ore - bearing wall rock. However, there are some debates about the relationship between dacite porphyry and mineralization in this mining area. With the breakthrough of prospecting for medium and large dacite porphyry ore bodies in recent years, the relationship between dacite porphyry and mineralization has once again become a concern. OBJECTIVES : In order to understand the relationship between dacite porphyry alteration and mineralization of the Dabaoshan deposit. METHODS: Based on field work and indoor analysis, this paper uses X - ray fluorescence spectrometry ( XRF) and inductively coupled plasma - mass spectrometry ( ICP - MS) to determine copper, tungsten, silicon, aluminum and calcium in Dabaoshan dacite porphyry samples. The isotope composition, metal element contents and alteration characteristics of the dacite porphyry in the mining area were used to discuss the relationship between alteration and prospecting direction. RESULTS: The copper content changes from 107 to 6909 µg/ g, which is consistent with the copper ore grade of 0. 3% - 0. 5% in the mining area. The LOI and other geochemical indicators that can represent the degree of alteration are positively correlated with copper. Hydrothermal alteration is widely developed in dacite porphyry, including potassium, prophyliticition and quartz - sericitization from early to late stage. Among different stages of alterations, the copper content of quartz - sericitization is 2 to 5 times higher than other alteration types, indicating that quartz - sericitization is closely related to copper mineralization and is an important prospecting sign. CONCLUSIONS: The deep alteration intensity of the dacite porphyry ( below the 270m elevation) has not been weakened, suggesting a great prospecting potential. In addition, the contact zone between dacite porphyry and the Jurassic strata, and the xenoliths in the dacite porphyry are also important prospecting directions, which may host skarn - type copper - rich deposits. [ABSTRACT FROM AUTHOR]

Pancreatic cancer, with the characteristics of insidious onset, easy metastasis, chemotherapy resistance and poor prognosis, is a common malignant tumor of the digestive system. Early diagnosis and treatment of pancreatic cancer is one of the major problems in modern medicine, and there is an urgent need to find new diagnostic, prognostic biomarkers and therapeutic targets. MicroRNA (miRNA) is a small non-coding RNA which can regulate the expression of various genes. miRNAs have wide abnormal expressions in pancreatic cancer, and are closely related to the occurrence and development of pancreatic cancer. Thereby, miRNAs have the potential to become new diagnostic, prognostic and predictive biomarkers and therapeutic targets of pancreatic cancer. Many studies have initially shown that miRNAs have the application value in the diagnosis, treatment and prognosis evaluation of pancreatic cancer, but there are still some difficulties in the practical application and promotion. The mechanisms of miRNAs in pancreatic cancer remain to be further studied. [ABSTRACT FROM AUTHOR]