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Objective To explore the use of a novel inflammatory composite scoring system with a column chart model to predict the risk of postoperative delirium in patients with lumbar spine fractures. Methods 251 patients with lumbar spine fracture who had been admitted to our hospital and had undergone surgical treatment from June 2020 to December 2022 were selected as study subjects, and then divided into a postoperative delirium group （n = 55） and a delirium-free group （n = 196） according to the patients' conditions. The clinical data of the two groups were recorded and subjected to univariate analysis. ROC curve was used to analyze the predictive value of the indexes for postoperative delirium in the patients; logistic regression was used to analyse the independent risk factors for postoperative delirium and construct a columnar graph model; the calibration curves were used for the internal validation of the model; the consistency index （C-index） was calculated; and the decision curve was used to evaluate the predictive efficiency of the model. Results The differences between the two groups in terms of age, surgical duration, intraoperative bleeding, and inflammatory response markers NLR, PLR, and CAR were statistically significant （P < 0.05）. The AUCs of age, surgical time, intraoperative bleeding, NLR, PLR, and CAR were 0.788, 0.714, 0.797, 0.824, 0.839, and 0.811, respectively; and the AUC of the constructed N.P.Cs scoring scale was 0.963. Age, intraoperative bleeding, and N.P.Cs were independent risk factors affecting postoperative delirium in patients with lumbar spine fractures. The calibration curve of the column-line diagram prediction model was close to the original and ideal curves, with a C-index of 0.847 （95% CI:0.811 ~ 0.903）; the threshold value of the column-line diagram prediction model was greater than 0.17, providing a net clinical benefit. Conclusion Age, intraoperative bleeding, and N.P.Cs are independent risk factors for postoperative delirium in patients with lumbar spine fractures. The column chart prediction model based on this construction can provide guidance for the prevention and treatment of postoperative delirium in patients with lumbar spine fractures. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factors of recessive blood loss in patients with lumbar disc herniation after surgery and establish a nomogram prediction model. Methods Two hundred patients with lumbar disc herniation who came to our hospital from February 2019 to August 2022 were selected as the research objects. According to the recessive blood loss after surgery, the patients were divided into positive group （n = 85） and negative group （n = 115）. ROC experiment was used to analyze the predictive value of continuous variables. Logistic regression experiment was used to analyze the risk factors of recessive blood loss in patients with lumbar disc herniation after operation. Internal data were used to verify the clinical efficacy of Nomogram model. Results There was no significant difference in gender, BMI and other general data between the two groups （P > 0.05）. Compared with the negative group, the patients in the positive group were older, and they had more perioperative blood transfusions, larger number of surgical segments, higher TC and TG levels, and lower postoperative hemoglobin levels （P < 0.05）. The AUCs of age, number of operative segments, TC, TG and postoperative hemoglobin were 0.611, 0.607, 0.602, 0.673, 0.791, respectively, with the optimal cutoff values 39 years, 2 segments, 4.96 mmol/L, 6.79 mmol/L, 107 g/L, respectively. Age （> 39 years）, perioperative blood transfusion, number of operative segments （> 2 segments）, TC （> 4.96 mmol/L）, TG （> 6.79 mmol/L）, and hemoglobin difference （> 44 g/L） were all risk factors for recessive blood loss in the patients （P < 0.05）. Nomogram model predicted the risk of occult blood loss in the patients after surgery by a C-index of 0.775 （95% CI: 0.669 ~ 0.848）, with a risk threshold of recessive blood loss > 0.07. Nomogram model predictively yielded clinical net benefits as well. Conclusion Age （> 39 years）, perioperative blood transfusion, number of operative segments （> 2 segments）, TC （> 4.96 mmol/L）, TG （> 6.79 mmol/L）, and hemoglobin difference （> 44 g/L） are all risk factors that affect the occurrence of recessive blood loss in patients with lumbar disc herniation after surgery. Nomogram model based on the above variables can better predict the occurrence of recessive blood loss in those patients. [ABSTRACT FROM AUTHOR]

The national science popularization capacity of the New Era is reflected in the comprehensive strength of one country, which contains the capacity to continuously provide science popularization products and services to the public, improve the scientific literacy of the whole people, cultivate social culture, promote the transformation of scientific and technological achievements, then support the national innovative development. Based on the theoretical research and construction practice of China's science popularization capacity, this study analyzes the deficiencies in the current construction of China's science popularization capacity and the development direction of national science popularization capacity to serve the national development strategy in the new era, and tries to put forward useful suggestions for strengthening the national popular science ability, serving the innovation-driven development and the realization of Chinese path to modernization. [ABSTRACT FROM AUTHOR]

To investigate the effects of Xiaoshuan Changrong capsule combined with argatroban on hemorheology and nerve injury in patients with acute cerebral infarction (ACI). 150 patients with ACI who were received in our hospital from January 2016 to December 2019 were selected, and they were randomly divided into control group (treated with conventional drugs and argatroban, 75 cases) and observation group (treated with conventional drugs, argatroban and Xiaoshuan Changrong capsule, 75 cases)by random number table method. The clinical efficacy, Barthel index, National Institutes of Health Stroke Scale (NIHSS) score, hemorheology and nerve injury indexes before and after treatment, and the occurrence of adverse drug reactions were compared between the two groups. The total effective rate in the observation group was higher than that in the control group (P＜0.05). Compared with the control group, Barthel index in the observation group after treatment was higher, and NIHSS score was lower (all P＜0.05). After treatment, fibrinogen, whole blood high / low shear viscosity and plasma viscosity in the observation group were lower than those in the control group (all P＜0.05). After treatment, the levels of serum neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100B protein in the observation group were lower than those in the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Xiaoshuan Changrong capsule combined with argatroban is effective in the treatment of ACI, and which can significantly improve the level of hemorheology and nerve injury indexes. [ABSTRACT FROM AUTHOR]

To investigate the effect of donepezil hydrochloride combined with comprehensive rehabilitation training on cognitive function, event-related potential and serum brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) in patients with senile dementia. 120 patients with senile dementia who were treated in our hospital from March 2017 to March 2020 were selected, they were divided into control group (n=60, donepezil hydrochloride treatment) and combination group (n=60, donepezil hydrochloride combined with comprehensive rehabilitation training treatment) according to random number table method. The efficacy, cognitive function scores, event-related potential and serum BDNF, IGF-1 before and 3 months after treatment, and the occurrence of adverse reactions during treatment of the two groups were compared. The total effective rate of the combination group was 91.67%, which was higher than 72.92% of the control group (P<0.05). The scores of activities of daily living (ADL) assessment scale, clinical dementia rating (CDR) in both groups decreased, and the combination group was lower than the control group (P<0.05), the scores of Mini Mental State Scale (MMSE) increased,, and the combination group was higher than that of the control group (P<0.05). N1 latency and P2 latency shortened, P3 amplitude increased in the two groups at 3 months after treatment, and the P2 latency in the combination group was shorter than that in control group at 3 months after treatment, P3 amplitude was higher than that in control group (P<0.05), there was no significant difference in N1 latency between the two groups at 3 months after treatment (P>0.05). The level of BDNF in the combination group at 3 months after treatment was significantly higher than that in control group (P<0.05), there was no significant difference in IGF-1 level of the two groups at 3 months after treatment (P>0.05). There was no statistical difference in the incidence of adverse reactions between control group and combination group (P>0.05). Combined with comprehensive rehabilitation training on the basis of donepezil hydrochloride, the cognitive function of patients with senile dementia can be significantly improved. At the same time, it can also adjust the event-related potential and the levels of serum BDNF and IGF-1. [ABSTRACT FROM AUTHOR]

Objective: To investigate the protective effects of OIP5 on the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cell line SMMC-7721. Methods: OIP5 was down-regulated by using small interfering RNA in HCC cell line SMMC-7721. The transfection efficiency of OIP5-siRNA was detected with qRT-PCR and Western blot. The proliferation of HCC cells was detected by CCK-8 and colony formation assay, and the migration and invasion of HCC cells were measured by Transwell assay.Results: The level of OIP5 mRNA and protein were significantly decreased after being transferred by OIP5-siRNA in SMMC-7721 cells.After knockdown of OIP5, the OD value measured by CCK-8, the number of conoly, metastasis and invaded cell number were significantly decreased compared with the control group(P<0.05). Conclusions: OIP5 can promote the proliferation, invasion and metastasis of HCC SMMC-7721 cells, and targeting OIP5 is likely to be a promising strategy for the treatment of HCC. [ABSTRACT FROM AUTHOR]

Mainly for the problem that various hidden dangers for safety are dfficult to be eliminated under the pure artificial or semi-artificial management metliods in electrical and electronic opening-laboratory in universities, a new type of intelligence management system has been invented. The system has intelligent software, simplistic hard, long-distanced management, incorporates self-service and high security. The system satisfies various operation requirements of the scene that no administrator in opening-laboratory because it sets the advanced wireless AP technology, electric power carrier, dynamic database technology, website construction technology and mobile Internet interactive technology. And the system's application effect is obvious in opening laboratories of Electrical and Electronic Technology Experiment Teaching Center of Chongqing University. Especially, during the winter and summer vacations, the open laboratory utilization rate reaches more than 80% . [ABSTRACT FROM AUTHOR]

To avoid the difficulty from laser spot alignment of existing laser collimation system in calibration process, a system composition is simplified, the efficiency and accuracy of calibration are improved, and the adaptability of calibration system is enhanced. A transformation matrix between calibration system and ballistic range system is presented by using the coordinates of three non-collinear points in calibration system and ballistic range system. The mean value and the variance-covariance matrix of the final measuring error are studied by an error model founded by Jacobian matrix between the measuring and various error sources.The self-covariance of measuring error is studied based on the Cauchy-Schwarz inequality and the relationship between vector and matrix norms. An firing experiment of live ammunition is performed to verify the three-point calibration method of ballistic range. The research results show that the mean vector length of final measuring error about a point in ballistic range system is equal to the mean vector length of measuring error associated with same point in the calibration system; the larger the distance and the area surrounded by three non-collinear points which links the calibration system and ballistic range system together are, the smaller the self-covariance of the final measuring error is; the self-covariance decreases when the transition coordinate origin which is defined by the three non-collinear points is close to a projected trajectory line; based on the measurement method and the error of the three-point coordinates in ballistic system, the self-covariance of measuring error are changed when the calibration system origin moves away from the ballistic range system origin; and the calibration system based on the three-point method can be build-up by general instruments, and the quality of measured data is better. [ABSTRACT FROM AUTHOR]

Objective To investigate value of preoperative magnetic resonance imaging (MRI) T2 fat suppression sequence in predicting isocitrate dehydrogenase (IDH)-1 gene expression in gliomas. Methods 124 patients with glioma, who were confirmed by histopathology, were collected. Regions of interest (ROI) was delineated using ITK-SNAP software. Pyradiomics package was used to extract radiomic features from the imaging data, while a pre-trained ResNet50 deep. learning model was employed to extract deep learning features. Feature selection was performed using the Pearson correlation coefficient and the Least Absolute Shrinkage and Selection Operator (LASSO) regression model. Model performance was evaluated through 10-fold cross-validation. Traditional radiomics, deep transfer learning, and fusion models were separately constructed based on support vector machine (SVM), k-nearest neighbors (KNN), and random forest (RF) machine learning algorithms. The predictive performance of each model was assessed using receiver operating characteristic (ROC) curve. Results The area under curve (AUC) for the machine learning models SVM, KNN, and RF based on radiomic features were 0.699, 0.628, and 0.616, respectively. For the machine learning models SVM, KNN, and RF hased on deep transfer learning features, the AUC values were 0.853, 0.753, and 0.807, respectively. The machine learning models SVM, KNN, and RF based on fusion features achieved AUC values of 0. 868, 0.818, and 0. 787, respectively. Conclusion The SVM fusion model based on the T2 WI fat suppression sequence in routine MRI exhibits higher predictive performance in determining the IDH-1 gene expression status in gliomas. [ABSTRACT FROM AUTHOR]

Objective Achieving efficient rapid demulsification of water-in-oil emulsion constructed of oil with high viscosity was realized. Methods The g-C3N4 was prepared from melamine by thermal polymerization method. The composite filter cake was prepared by mixing super-hydrophilic g-C3N4 with diatomite, and the high viscosity water-in-oil emulsion was quickly demulsified by pumping and filtering. ResultsThe filter cake containing 1.5 wt% g-C3N4 with 0.5 cm thickness can realize completely demulsified, which the emulsion with water content less 6 wt% and droplet size larger than 2.32 μm. The demulsification rate of 20 kPa vacuum degree can reach 3.57 L/min, the demulsification efficiency is 97.36%, and the oil recovery rate is above 99.72%. Thickening the filter cake can be used for demulsification of emulsion with higher water content. Such attractive demulsification effect is caused by the simultaneous action of strong affinity of g-C3N4 to water and the crushing effect by micropores of diatomite. Conclusion The g-C3N4/diatomite composite filter cake can be effectively used for efficient rapid demulsification of water-in-oil emulsion with promising application prospect. [ABSTRACT FROM AUTHOR]

The direct numerical simulation based on the current density conservative scheme was employed to calculate the turbulent Taylor-Couette flow of an electrically conducting fluid in an axial magnetic field. The generation of negative velocity due to the interaction of magnetic field with induced current， and the effect of magnetic field on the mean flow field were revealed， when two cylinders had the same potentials. By using two kinds of averaged method， the total fluctuations in the flow field were divided into two parts，i.e.， the contribution of mean Taylor vortex flow and the contribution of turbulence. Consequently， several cases were calculated to investigate the effect of magnetic field on the contribution， and comparation the effects of axial magnetic field on from mean Taylor vortex flow and the turbulent flow. [ABSTRACT FROM AUTHOR]

Osteoporosis is a metabolic disease characterized by a decrease in bone density and destruction of bone microarchitecture, often resulting in fractures. As a newly discovered form of programmed cell death at 2012, ferroptosis is mainly characterized by iron overload and accumulation of ROS, leading to lipid peroxidation. Recently, more and more studies have shown that ferroptosis plays an important role in osteoporosis. Therefore, in this paper, the new research progress of ferroptosis and osteoporosis are reviewed. [ABSTRACT FROM AUTHOR]

The pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD) are closely associated with the activation of the innate immune system. This article reviews how various types of immune cells, Toll-like receptors, and their downstream signaling pathways are involved in insulin resistance and mediate oxidative stress, inflammation, and fibrosis in the liver. Reduction or elimination of dendritic cells delays inflammatory responses and fibrosis in the liver. A decrease in natural killer T cells induces lipid accumulation at the stage of simple steatosis, but alleviates fibrosis at the inflammation stage. The mTOR signaling pathways for insulin and amino acids suppresses autophagy through short-term or long-term regulation, which leads to endoplasmic reticulum stress and altered insulin resistance, thereby modulating the development and progression of NAFLD. The research on the mechanisms by which traditional Chinese medicine offers therapeutic benefits for NAFLD increasingly focuses on the potential role of immunity. [ABSTRACT FROM AUTHOR]

Objective To obtain highly purified astrocytes and identify the cells in each stage to support further studies. Methods The cerebral cortex of a neonatal SD rat was isolated and prepared into single cell suspension. The obtained cells were purified by differential adherence and shook at a constant temperature. By inverted phase contrast microscopy and HE staining, cell morphology was observed. The immunofluorescence staining with anti-mouse GFAP was used to identify the cells. Results The primary cortical cells developed rapidly at 3d after culture and covered the flasks at 9-12d. At this time, the cells showed stratification and the astrocytes lay at the lower layer. GFAP positive rate was only about (67.2±7.1)%. After the first passage, GFAP positive rate increased obviously (84.0±6.0)%. However, oligodendrocytes and microglias could not be removed completely, and the cells also showed stratification. Through 3 times of passages, we obtained many single species of astrocytes showing satellite shape with 2 or 3 processes, big cell body and round or oval-shaped nuclei leaned to one side. Immunofluorescence staining showed that nearly all of the cells were strong positive and the positive rate reached as high as (97.6±2.4)%. Conclusion Through differential adherence and shaking at a constant temperature, more astrocytes of high purity and in good state can be obtained. [ABSTRACT FROM AUTHOR]