盐酸多奈哌齐联合综合康复训练对老年痴呆患者认知功能、事件相关电位及血清BDNF、IGF-1的影响.

To investigate the effect of donepezil hydrochloride combined with comprehensive rehabilitation training on cognitive function, event-related potential and serum brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) in patients with senile dementia. 120 patients with senile dementia who were treated in our hospital from March 2017 to March 2020 were selected, they were divided into control group (n=60, donepezil hydrochloride treatment) and combination group (n=60, donepezil hydrochloride combined with comprehensive rehabilitation training treatment) according to random number table method. The efficacy, cognitive function scores, event-related potential and serum BDNF, IGF-1 before and 3 months after treatment, and the occurrence of adverse reactions during treatment of the two groups were compared. The total effective rate of the combination group was 91.67%, which was higher than 72.92% of the control group (P<0.05). The scores of activities of daily living (ADL) assessment scale, clinical dementia rating (CDR) in both groups decreased, and the combination group was lower than the control group (P<0.05), the scores of Mini Mental State Scale (MMSE) increased,, and the combination group was higher than that of the control group (P<0.05). N1 latency and P2 latency shortened, P3 amplitude increased in the two groups at 3 months after treatment, and the P2 latency in the combination group was shorter than that in control group at 3 months after treatment, P3 amplitude was higher than that in control group (P<0.05), there was no significant difference in N1 latency between the two groups at 3 months after treatment (P>0.05). The level of BDNF in the combination group at 3 months after treatment was significantly higher than that in control group (P<0.05), there was no significant difference in IGF-1 level of the two groups at 3 months after treatment (P>0.05). There was no statistical difference in the incidence of adverse reactions between control group and combination group (P>0.05). Combined with comprehensive rehabilitation training on the basis of donepezil hydrochloride, the cognitive function of patients with senile dementia can be significantly improved. At the same time, it can also adjust the event-related potential and the levels of serum BDNF and IGF-1. [ABSTRACT FROM AUTHOR]