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In order to improve the tracking performance of cognitive radar, this paper proposes a waveform selection algorithm for cognitive radar tracking assisted by amplitude information. Firstly, the framework of waveform parameter selection for cognitive radar tracking is discussed. Secondly, the performance of amplitude-assisted tracking probability data association is analyzed, and the method of waveform parameter selection is proposed. Finally, combined with the Interactive Multiple Model Unscented Kalman Filter(IMMUKF), an amplitude information assisted waveform selection algorithm for cognitive radar tracking is proposed. Simulation results show that the proposed algorithm can effectively improve the target tracking performance and reduce the probability of target tracking loss. [ABSTRACT FROM AUTHOR]

The study was to optimize the extraction process of polysaccharides from Hericium hericium residues by ultrasonic method. The effect of four factors (liquid to solid ratio, ultrasonic power, ultrasonic time and ultrasonic times) on the extraction rate of Hericium hericium residue were studied. The orthogonal analysis method was used to optimize the combination of production parameters, and the extraction rate of polysaccharides from Hericium hericium residue under the optimal process parameters was investigated, and the antioxidant activity in vitro was detected. The results showed that the order of factors affecting the extraction rate of polysaccharide from Hericium hericium residues was liquid to solid ratio > ultrasonic times > ultrasonic power > ultrasonic time. The optimal combination of extraction parameters was liquid to solid of 15 mL/g, ultrasonic power of 350 W, ultrasonic time of 15 min and ultrasonic times of 2. Under the condition of the process, Hericium hericium residues polysaccharides extraction yield of 8.85%. The in vitro antioxidant test showed that the scavenging rates of DPPH free radical, superoxide anion free radical and ABTS+ free radical were 88.03%, 67.42% and 97.83%, respectively, which had a certain antioxidant ability. The study indicates that the experimental results can provide reference for the optimization of production process and the development of feeding and utilization value of polysaccharides extracted from Hericium hericium residue. [ABSTRACT FROM AUTHOR]

In order to study the waveform selection of radar seeker in the terminal guidance and tracking phase, this paper proposes a waveform selection algorithm in the guidance and tracking process of cognitive radar seeker. Firstly, we establish the processing flow of radar seeker waveform selection by combining the seeker guidance and observation filtering models; Secondly, we use the interactive multiple model unscented Kalman filter (IMMUKF) algorithm to solve the nonlinear tracking problem. We minimize tracking error by searching for waveform parameters based on the maximum mutual information criterion. The simulation results show that the waveform selection algorithm can effectively improve the seeker tracking accuracy and provide stable guidance overload. [ABSTRACT FROM AUTHOR]

目的 探讨以患者为中心的优质护理干预在门诊手足口病患儿中的应用。方法 选取该院 2018 年 4 月至 2022 年 4 月门诊收治的手足口病患儿 100 例为研究对象,按照数字表法进行随机分组,分为对 照组及研究组,每组 50 例。对照组接受常规护理,研究组则接受以患者为中心的优质护理干预,对比两组护理 效果。结果 研究组患儿生活质量各维度评分均较对照组高,差异均有统计学意义 (P<0.05)。干预前,两组 患儿家属对手足口病知识掌握度评分、日常卫生保健行为实施情况比较,差异均无统计学意义 (P>0.05);干预 后,研究组患儿家属对手足口病知识掌握度各维度评分及总分、日常卫生保健行为各维度遵从率均较对照组 高,差异均有统计学意义 (P<0.05)。结论 对门诊手足口病患儿运用以患者为中心的优质护理干预,能有效 地改善患儿生活质量,提升患儿家属对手足口病知识掌握度,改善日常卫生保健行为,值得推广。 [ABSTRACT FROM AUTHOR]

Objective: To study the influence of perinatal exposure of bisphenol A (BPA) at a low dose on the spermatogenesis of male offspring rats. Methods: Pregnant rats were injected subcutaneously with BPA 2 μg/(kg·d) from gestation day 10 through lactation day 7, and the same volume of olive oil was used as the blank control. Their male offspring were served as the BPA group and the control group. Histological structure of the testis and the related regulation genes such as cyclin A1、cyclin B、c-jun and c-fos, as well as the FSH and LH, were tested, and the expressions POA-GnRH or ARC-kiss1 mRNAs were also examined in their male offspring during the postnatal day 18, 21, 24. Results: In comparison with the control group, the seminiferous tubular diameter, the number of round spermatids and the ratio of seminiferous tubule with round spermatids were significantly increased in PND24 BPA rats (P＜0.05). The expression levels of cyclin A1, c-jun and c-fos mRNAs in the testes were significantly elevated in PND21 BPA rats (P＜0.01). Similarly, the levels of plasma FSH and LH were increased in the PND21/24 BPA rats compared with the control rats (P＜0.05). But the levels of plasma T and E2 were no significant in the PND18/21/24 BPA rats and the control rats (P＞0.05). In comparison with control group, the expression levels of POA-GnRH mRNA and ARC-kiss1 mRNA were significantly increased in PND21 BPA rats (GnRH: P＜0.05; kiss1: P＜0.01). Conclusions: In addition to the direct effect of BPA on the testes of male offspring, the perinatal exposure to a low dose of BPA promotes spermatogenesis via advancing the pubertal activation of ARC -kisspeptin, and via further enhancing the expressions of meiotic regulation genes in the testes of male offspring. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of synergistic intervention of interferonα(IFNα) and thymopentin(TP5) on the mRNA expression of apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 A(APOBEC3 A) and apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 B(APOBEC3 B) in HepG2. 2. 15 cells. Methods HepG2. 2. 15 cells were divided into blank control group, IFNα treatment group, TP5 treatment group, and IFNα + TP5 treatment group, and at 12, 24, 48, and 72 hours of treatment, quantitative real-time PCR was used to measure the mRNA expression of APOBEC3 A and APOBEC3 B in HepG2. 2. 15 cells. An analysis of variance was used for comparison of continuous data between multiple groups, and the least significant difference t-test was used for further comparison between two groups. Results Compared with the blank control group, the IFNα treatment group and the IFNα + TP5 treatment group had a significant increase in the mRNA expression of APOBEC3 A at 12, 24, 48, and 72 hours of treatment(all P < 0. 001). Compared with the IFNα treatment group, the IFNα + TP5 treatment group had a significant increase in the mRNA expression of APOBEC3 A at these four time points(all P < 0. 001). TP5 treatment had no significant influence on the mRNA expression of APOBEC3 A at each time point(all P > 0. 05). There was no significant difference in the mRNA expression of APOBEC3 B between the blank control group and the treatment groups(all P > 0. 05). Conclusion IFNα combined with TP5 can significantly upregulate the mRNA expression of APOBEC3 A in HepG2. 2. 15 cells. [ABSTRACT FROM AUTHOR]

Objective To investigate the change in the level of T-cell receptor rearrangement excision circles (TREC) after antiviral therapy with thymopentin (TP5) and entecavir (ETV) in HBeAg-positive chronic hepatitis B (CHB) patients. Methods A total of 30 HBeAg-positive CHB patients who were diagnosed and treated in Beijing YouAn Hospital, Capital Medical University, from October 2014 to September 2016 were enrolled. All patients were given ETV combined with TP5 for 48 weeks. Real-time PCR was used to measure the level of TREC in peripheral blood mononuclear cells (PBMCs), and the change in TREC after treatment was analyzed. The correlation of TREC level with HBV DNA, HBeAg, and HBsAg was analyzed. The t-test was used for comparison of continuous data between two groups, and a Spearman correlation analysis was used to investigate the correlation between two indices. Results After the combined treatment for 48 weeks, 24 patients achieved virologic response, and 3 achieved HBeAg clearance. The level of TREC significantly increased from 6.03±1.71 copies/103 PBMCs before treatment to 10.61±2.08 copies/103 PBMCs after treatment (t=9.32, P＜0.0001). The patients in the virologic response group had a significant increase in the level of TREC after treatment (11.21±1.71 copies/103 PBMCs vs 5.79±1.84 copies/103 PBMCs, t=10.57, P＜0.0001), while those in the non-virologic response group had no significant change in the level of TREC after treatment (8.21±2.08 copies/103 PBMCs vs 7.03±0.28 copies/103 PBMCs, t=1.38, P=0.20). Before treatment, there was no significant difference in the level of TREC in PBMCs between the virologic response group and the non-virologic response group (P＞0.05), while after treatment, the virologic response group had a significantly higher level of TREC than the non-virologic response group (t=3.69, P=0.001). A bivariate Spearman correlation analysis was performed for the levels of TREC, HBsAg, and HBeAg, HBV DNA load, and the degree of reductions from baseline to 48 weeks of treatment, and no statistical significance was found. Conclusion TP5 combined with ETV can increase thymic output function in HBeAg-positive CHB patients. [ABSTRACT FROM AUTHOR]

Objective To analyze the existing problems of the hospital logistics service to offer the suggestions through analyzing the satisfactory situation of the medical staffs in the tertiary general hospitals on the hospital logistics service to provide reference for improving the level of logistics support service. Methods The questionnaire survey was conducted among 573 medical staffs randomly extracted from the tertiary general hospitals by using the self-designed logistics service satisfactory questionnaire. Results The average total score of medical staff satisfaction to hospital logistics service was (3.41 ± 1.14) points, moreover the satisfaction to clean keeping and environment greening was the lowest, the average score was (2.65 ± 1.20) points, followed by the sentry management (2.83 ± 1.23) points,and equipment and material procurement (2.95 ± 1.18) points. Conclusion The satisfaction of medical staffs in the tertiary general hospitals to logistics service is not high, and the tertiary general hospital logistics management needs to be improved and perfected from the aspects of auxiliary technology intelligence, process simplification,and supervision strengthening of outsourced services and so on. [ABSTRACT FROM AUTHOR]

Objective To evaluate the value of a torvastatin combined with trimetazidine for increasing the effect and safety in treating the patients with coronary heart disease(CHD). Methods Sixty eight patients with CHD treated by the medication in this hospital from February 2018 to September 2019 served as the study subjects and divided into the study group and reference group by adopting the random lottery method, 34 cases in each group. The study group adopted the atorvastatin combined with trimetazidine treatment on the basis of routine therapy, while the reference group adopted the trimetazidine treatment on the basis of routine therapy. The treatment effect and adverse reactions occurrence situation as well as the left ventricular endsystolic inner diameter, left ventricular ejection fraction and C reactive protein (CRP) before medication and after 3 month treatment in the two groups conducted the statistics. Results The total effective rate in the study group was significantly higher than that in the reference group, and the difference was statistically significant (P<0.05). The occurrence rate of adverse reactions in the study group was lower than that in the reference group, and the difference had no statistical significance(P>0.05). After 3 month treatment, the left ventricular end systolic inner diameter and CRP level in the study group were significantly lower than those before treatment and after 3 month treatment in the reference group, and the differences were statistically significant ( P<0.05), while the left ventricular ejection fraction after 3month treatment in the study group was significantly higher than that before treatment and after 3 month treatment in the reference group, and the differences were statistically significant ( P< 0.05). Conclusion Adopting atorvastatin plus trimetazidine for treating the patients with CHD is helpful to increase the medication effect with less adverse reactions and good medication safety. [ABSTRACT FROM AUTHOR]

目的观察更换胃管时胃液滴入咽喉致胃食管反流病（GERD)的护理效果。方法选取该院2016年 6月至2017年6月收治的更换胃管时胃液滴入咽喉致GERD患者100例，按不同护理方法分为常规组和综合组，每组 50例。常规组实施常规护理，综合组实施综合护理，对比两组患者护理效果。结果综合组患者护理后GERD问卷评分 [(6.8±2.2)分]明显低于常规组[(11.0±2.4)分]，生活质量指数评定量表评分[(90.5±4.9)分]、患者满意度[98.0%(49/50)]均 明显高于常规组[分别为（78.9±6.8)分、86.0%(43/50)]，差异均有统计学意义（P<0.05)。结论对更换胃管时胃液滴入咽 喉致GERD患者实施综合护理可有效缓解患者临床症状，有助于提升患者生活质量与护理满意度，值得推行。 [ABSTRACT FROM AUTHOR]

目的分析和评价老年顽固性心力衰竭（RHF)患者应用硝普钠联合多巴胺治疗的疗效。方法选取该 院心内科2016年2月至2017年2月收治的老年BHF患者94例作为研究对象，采用随机数字表法分成探究组和对比组， 每组47例。对比组应用常规药物治疗，探究组同时应用硝普钠联合多巴胺治疗，两组患者均连续治疗7 d，对比两组疗 效，并评估两组患者治疗前后心功能改善情况。结果探究组患者总有效率明显高于对比组，两组患者治疗后心率、左 心室射血分数、左心室舒张末直径、左心室短轴缩短率、心胸比率均明显改善，且探究组患者改善效果更优于对比组，差 异均有统计意义（P<0.05)。两组患者均未发生严重不良反应。结论对老年RHF患者采用硝普钠联合多巴胺治疗效果 确切，能更好地改善患者心功能，且安全性较高，具有重要的临床应用价值。 [ABSTRACT FROM AUTHOR]

目的探討綜合訓練對老年血管性癡呆(VD)患者的效果。方法選取2011年12月至2013年12月在該院接受治療的VD患者98例作為研究對象,按照入院編號分為干預組(奇數號)和對照組(偶數號),各49例。對照組接受臨床常規藥物治療,干預組在對照組治療基礎上給予綜合訓練,其中包括日常生活能力(ADL)訓練、認知功能訓練及其他訓練。比較分析兩組患者干預前及干預3、6個月后Barthel指數(BI)、簡易精神狀態量表(MMSE)及長谷川癡呆量表(HDS)等評分情況。結果干預前,兩組患者ADL、MMSE及HDS 3項評分比較,差異均無統計學意義(P>0.05);3、6個月后,干預組ADL、MMSE及HDS評分均明顯高于干預前和對照組,差異均有統計學意義(P<0.05);干預組干預6個月后ADL、MMSE及HDS評分與干預3個月后比較,差異均有統計學意義(P<0.05)。結論綜合訓練能延緩VD患者功能障礙,改善癡呆程度,提高認知功能,改善生存和生活質量,近期療效顯著。 [ABSTRACT FROM AUTHOR]

Objective To explore and analyze the clinical characteristics and prognosis of 248 patients with novel coronavirus pneumonia (COVID-19) in Chongqing, so as to provide reference for clinical diagnosis and treatment of COVID-19. Methods The clinical data of 248 patients with COV ID-19 admitted to the hospital from January 21 to March 11, 2020 were retrospectively analyzed, including 195 patients in the non-severe group (mild type/normal type) and the severe group (severe type/critical type). Type) 53 cases. Comparing the general conditions, clinical manifestations, laboratory test results and prognosis of the two groups of patients, the average age of 248 patients was (47.69±15.59) years old. Adults accounted for 97.6% (242/248), men were slightly more than women (54.0% (134/248), 46.0% (114/248), respectively), hospitalization time was 14.00 (12.00, 22,000 days. The fatality rate was 16% ( 4/248), the fatality rate of patients in the severe group was 7.5% (4/53). After the cured patients were discharged from the hospital, 4 patients in the non-critical group were followed up for reimpedance, and there was no evidence of infecting others. The age of the severe group patients, as well as diabetes and chronic obstruction The proportions of pulmonary disease, coronary heart disease, malignant tumors, cough, sputum, shortness of breath, dyspnea, and fatigue are all significantly higher than those of the non-severe group. The counts of lymphocytes, monocytes, lymphocytes, total T lymphocytes, Helper/inducible T lymphocytes, inhibitory/cytotoxic T lymphocytes, B lymphocytes, and natural killer cells are significantly lower than the non-severe group, neutrophils, urea nitrogen, direct bilirubin, aspartate aminotransferase, prothrombin time, Partially activated prothrombin time, D-dimer. C-reactive protein, procalcitonin, and interleukin-6 were significantly higher than those in the non-critical group, and the differences were statistically significant (P<0.05). Conclusions Elderly Patients with diabetes mellitus, chronic obstructive pulmonary disease, coronary heart disease, malignant tumors and other diseases are more likely to progress to severe cases. Clinical medical advancement combines patient symptoms and related laboratory test results to identify critically ill patients early and admit them to the intensive care unit for enhanced monitoring and treatment. Reduce the fatality rate of COVID 19 patients. [ABSTRACT FROM AUTHOR]

Objective：To investigate the effect of age on the clinical outcomes of in vitro fertilization - embryo transfer (IVF-ET). Methods: The clinical data of 4 512 infertile women who received IVF-ET in our Reproductive Medicine Center from January 2013 to July 2017 was analyzed retrospectively. All subjects were divided into six groups: younger than 35 years (3 619 cases, 11 patients were lost in follow-up), aged 35-37 years (479 cases), aged 38-40 years (262 cases), aged 41-42 years (90 cases), aged 43-44 years (39 cases), and older than 44 years (23 cases). The clinical pregnancy rate, first -trimester abortion rate, late abortion rate, ectopic pregnancy rate and live birth rate were compared among six groups. Results: There were decreases with age in the clinical pregnancy rate (P＜0.000 1), while the clinical pregnancy rate was best in the group of ＜35 years (54.42%). Meanwhile，the early abortion rate was increased significantly with age, especially in the women over 35 years (P＜0.01), and almost reached to 40% in the women more than 40 years. The live birth rate was decreased with age (P＜0.000 1), and this rate was 0 in those women aged more than 44 years. Conclusions: Age is a key factor related to the clinical outcomes of IVF-ET. The early intervention treatment should be advocated in those infertile women aged over 38 years because of the poor clinical outcomes. [ABSTRACT FROM AUTHOR]

Objective To investigate the features of insulin resistance in patients with liver disease and diabetes and possible pathways leading to insulin resistance. MethodsA total of 67 patients with liver disease and type 2 diabetes who were admitted to Beijing You’an Hospital from September 2017 to March 2018 were enrolled. The insulin secretory function of pancreas islet B cells and insulin resistance in the stages of chronic hepatitis and liver cirrhosis were analyzed. The presence or absence rs2943650 mutation was detected, and the association between rs2943650 mutation and insulin resistance in different degrees of liver injury was analyzed. The t-test or the rank sum test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. ResultsThere was no significant difference in the secretory function of pancreas islet B cells between the patients with chronic hepatitis and type 2 diabetes and those with liver cirrhosis and type 2 diabetes (52.72±34.56 vs 52.35±36.59, t=0.24, P=0.99), while there was a significant difference in insulin resistance index (1.33±0.62 vs 2.08±1.79, t=2.27, P=0.02). There was a significant difference in insulin resistance between the patients with rs2943650 mutation and those without such mutation (t=2.11, P=0.04). There was a significant difference in the presence or absence of rs2943650 mutation between different stages of liver disease (χ2=6.73, P=0.01), and rs2943650 mutation was more common in patients with liver cirrhosis. ConclusionIn patients with chronic liver disease and diabetes, there is no significant reduction in the function of pancreas islet B cells with the increase in the degree of liver injury, while there is a significant increase in insulin resistance. The rs2943650 mutation is significantly associated with insulin resistance and increases significantly with the aggravation of liver injury, and therefore, it may be an important pathway for insulin resistance induced by liver disease and diabetes. [ABSTRACT FROM AUTHOR]

患者安全是医院质量管理与医疗安全的目标之一，也是近年来医院等级评价的指标之一。如何将患者 安全融入医院文化，并植入每个员工的意识深处，成为指导员工工作的行为指南，这对医院管理和教育模式提出新的挑 战。该文阐述重庆医科大学附属第一医院近10 年的患者安全教育模式探索，将患者安全这一理念从引入文化到拓展外 延，从学习内涵到培训精髓，从借鉴经验到探索革新，形成一套适合中国医院的教育模式。与“优质护理服务示范工程” 活动相结合，促进公立医院改革和护理事业发展；与慢性病管理相结合，从医院走向社区走入家庭，将安全文化带入患 者家内，指导患者家属参与患者照顾。多方面的患者安全措施落实，从而为医院患者安全教育模式提供管理参考。 [ABSTRACT FROM AUTHOR]